-- dump date 20140620_062917 -- class Genbank::misc_feature -- table misc_feature_note -- id note 399741000001 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 399741000002 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 399741000003 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 399741000004 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 399741000005 Phage tail tube protein FII; Region: Phage_tube; pfam04985 399741000006 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 399741000007 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094 399741000008 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 399741000009 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 399741000010 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 399741000011 oligomer interface [polypeptide binding]; other site 399741000012 Clp protease; Region: CLP_protease; pfam00574 399741000013 active site residues [active] 399741000014 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 399741000015 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 399741000016 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 399741000017 ParB-like nuclease domain; Region: ParBc; pfam02195 399741000018 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 399741000019 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 399741000020 ParB-like nuclease domain; Region: ParBc; pfam02195 399741000021 Methyltransferase domain; Region: Methyltransf_23; pfam13489 399741000022 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 399741000023 ParB-like nuclease domain; Region: ParBc; pfam02195 399741000024 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 399741000025 BRO family, N-terminal domain; Region: Bro-N; cl10591 399741000026 Protein of unknown function (DUF551); Region: DUF551; pfam04448 399741000027 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 399741000028 active site 399741000029 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 399741000030 active site 399741000031 Methyltransferase domain; Region: Methyltransf_25; pfam13649 399741000032 ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554 399741000033 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 399741000034 ParA-like protein; Provisional; Region: PHA02518 399741000035 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 399741000036 P-loop; other site 399741000037 Magnesium ion binding site [ion binding]; other site 399741000038 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 399741000039 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741000040 non-specific DNA binding site [nucleotide binding]; other site 399741000041 salt bridge; other site 399741000042 sequence-specific DNA binding site [nucleotide binding]; other site 399741000043 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 399741000044 IncFII RepA protein family; Region: IncFII_repA; pfam02387 399741000045 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 399741000046 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 399741000047 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 399741000048 Baseplate J-like protein; Region: Baseplate_J; pfam04865 399741000049 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 399741000050 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 399741000051 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 399741000052 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 399741000053 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 399741000054 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 399741000055 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 399741000056 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 399741000057 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 399741000058 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 399741000059 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 399741000060 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 399741000061 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 399741000062 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 399741000063 beta subunit interaction interface [polypeptide binding]; other site 399741000064 Walker A motif; other site 399741000065 ATP binding site [chemical binding]; other site 399741000066 Walker B motif; other site 399741000067 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 399741000068 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 399741000069 core domain interface [polypeptide binding]; other site 399741000070 delta subunit interface [polypeptide binding]; other site 399741000071 epsilon subunit interface [polypeptide binding]; other site 399741000072 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 399741000073 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 399741000074 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 399741000075 alpha subunit interaction interface [polypeptide binding]; other site 399741000076 Walker A motif; other site 399741000077 ATP binding site [chemical binding]; other site 399741000078 Walker B motif; other site 399741000079 inhibitor binding site; inhibition site 399741000080 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 399741000081 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 399741000082 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 399741000083 gamma subunit interface [polypeptide binding]; other site 399741000084 epsilon subunit interface [polypeptide binding]; other site 399741000085 LBP interface [polypeptide binding]; other site 399741000086 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 399741000087 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 399741000088 Substrate binding site; other site 399741000089 Mg++ binding site; other site 399741000090 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 399741000091 active site 399741000092 substrate binding site [chemical binding]; other site 399741000093 CoA binding site [chemical binding]; other site 399741000094 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 399741000095 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 399741000096 glutaminase active site [active] 399741000097 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 399741000098 dimer interface [polypeptide binding]; other site 399741000099 active site 399741000100 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 399741000101 dimer interface [polypeptide binding]; other site 399741000102 active site 399741000103 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741000104 substrate binding pocket [chemical binding]; other site 399741000105 membrane-bound complex binding site; other site 399741000106 hinge residues; other site 399741000107 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 399741000108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741000109 dimer interface [polypeptide binding]; other site 399741000110 conserved gate region; other site 399741000111 putative PBP binding loops; other site 399741000112 ABC-ATPase subunit interface; other site 399741000113 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 399741000114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741000115 dimer interface [polypeptide binding]; other site 399741000116 conserved gate region; other site 399741000117 putative PBP binding loops; other site 399741000118 ABC-ATPase subunit interface; other site 399741000119 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 399741000120 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 399741000121 Walker A/P-loop; other site 399741000122 ATP binding site [chemical binding]; other site 399741000123 Q-loop/lid; other site 399741000124 ABC transporter signature motif; other site 399741000125 Walker B; other site 399741000126 D-loop; other site 399741000127 H-loop/switch region; other site 399741000128 transcriptional regulator PhoU; Provisional; Region: PRK11115 399741000129 PhoU domain; Region: PhoU; pfam01895 399741000130 PhoU domain; Region: PhoU; pfam01895 399741000131 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 399741000132 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741000133 substrate binding pocket [chemical binding]; other site 399741000134 membrane-bound complex binding site; other site 399741000135 hinge residues; other site 399741000136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741000137 dimer interface [polypeptide binding]; other site 399741000138 conserved gate region; other site 399741000139 putative PBP binding loops; other site 399741000140 ABC-ATPase subunit interface; other site 399741000141 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 399741000142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741000143 dimer interface [polypeptide binding]; other site 399741000144 conserved gate region; other site 399741000145 putative PBP binding loops; other site 399741000146 ABC-ATPase subunit interface; other site 399741000147 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 399741000148 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 399741000149 motif II; other site 399741000150 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 399741000151 Predicted flavoprotein [General function prediction only]; Region: COG0431 399741000152 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 399741000153 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 399741000154 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 399741000155 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 399741000156 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 399741000157 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 399741000158 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 399741000159 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 399741000160 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 399741000161 trmE is a tRNA modification GTPase; Region: trmE; cd04164 399741000162 G1 box; other site 399741000163 GTP/Mg2+ binding site [chemical binding]; other site 399741000164 Switch I region; other site 399741000165 G2 box; other site 399741000166 Switch II region; other site 399741000167 G3 box; other site 399741000168 G4 box; other site 399741000169 G5 box; other site 399741000170 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 399741000171 membrane protein insertase; Provisional; Region: PRK01318 399741000172 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 399741000173 hypothetical protein; Validated; Region: PRK00041 399741000174 ribonuclease P; Reviewed; Region: rnpA; PRK01732 399741000175 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 399741000176 DnaA N-terminal domain; Region: DnaA_N; pfam11638 399741000177 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 399741000178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741000179 Walker A motif; other site 399741000180 ATP binding site [chemical binding]; other site 399741000181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 399741000182 Walker B motif; other site 399741000183 arginine finger; other site 399741000184 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 399741000185 DnaA box-binding interface [nucleotide binding]; other site 399741000186 DNA polymerase III subunit beta; Validated; Region: PRK05643 399741000187 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 399741000188 putative DNA binding surface [nucleotide binding]; other site 399741000189 dimer interface [polypeptide binding]; other site 399741000190 beta-clamp/clamp loader binding surface; other site 399741000191 beta-clamp/translesion DNA polymerase binding surface; other site 399741000192 recF protein; Region: recf; TIGR00611 399741000193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741000194 Walker A/P-loop; other site 399741000195 ATP binding site [chemical binding]; other site 399741000196 Q-loop/lid; other site 399741000197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741000198 ABC transporter signature motif; other site 399741000199 Walker B; other site 399741000200 D-loop; other site 399741000201 H-loop/switch region; other site 399741000202 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 399741000203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741000204 Mg2+ binding site [ion binding]; other site 399741000205 G-X-G motif; other site 399741000206 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 399741000207 anchoring element; other site 399741000208 dimer interface [polypeptide binding]; other site 399741000209 ATP binding site [chemical binding]; other site 399741000210 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 399741000211 active site 399741000212 putative metal-binding site [ion binding]; other site 399741000213 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 399741000214 sugar phosphate phosphatase; Provisional; Region: PRK10513 399741000215 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741000216 active site 399741000217 motif I; other site 399741000218 motif II; other site 399741000219 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 399741000220 hypothetical protein; Provisional; Region: PRK06815 399741000221 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 399741000222 tetramer interface [polypeptide binding]; other site 399741000223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741000224 catalytic residue [active] 399741000225 YheO-like PAS domain; Region: PAS_6; pfam08348 399741000226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 399741000227 HTH domain; Region: HTH_22; pfam13309 399741000228 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 399741000229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741000230 putative substrate translocation pore; other site 399741000231 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 399741000232 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 399741000233 putative ligand binding site [chemical binding]; other site 399741000234 NAD binding site [chemical binding]; other site 399741000235 catalytic site [active] 399741000236 Transcriptional regulators [Transcription]; Region: FadR; COG2186 399741000237 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741000238 DNA-binding site [nucleotide binding]; DNA binding site 399741000239 FCD domain; Region: FCD; pfam07729 399741000240 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 399741000241 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 399741000242 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 399741000243 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 399741000244 active site 399741000245 intersubunit interface [polypeptide binding]; other site 399741000246 catalytic residue [active] 399741000247 galactonate dehydratase; Provisional; Region: PRK14017 399741000248 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 399741000249 putative active site pocket [active] 399741000250 putative metal binding site [ion binding]; other site 399741000251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741000252 D-galactonate transporter; Region: 2A0114; TIGR00893 399741000253 putative substrate translocation pore; other site 399741000254 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 399741000255 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 399741000256 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 399741000257 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 399741000258 putative dimer interface [polypeptide binding]; other site 399741000259 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 399741000260 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 399741000261 putative dimer interface [polypeptide binding]; other site 399741000262 putative transporter; Validated; Region: PRK03818 399741000263 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 399741000264 TrkA-C domain; Region: TrkA_C; pfam02080 399741000265 TrkA-C domain; Region: TrkA_C; pfam02080 399741000266 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 399741000267 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 399741000268 oligomeric interface; other site 399741000269 putative active site [active] 399741000270 homodimer interface [polypeptide binding]; other site 399741000271 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 399741000272 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 399741000273 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741000274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741000275 homodimer interface [polypeptide binding]; other site 399741000276 catalytic residue [active] 399741000277 alpha-amylase; Reviewed; Region: malS; PRK09505 399741000278 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 399741000279 active site 399741000280 catalytic site [active] 399741000281 Predicted transcriptional regulator [Transcription]; Region: COG3905 399741000282 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 399741000283 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 399741000284 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 399741000285 dimerization interface [polypeptide binding]; other site 399741000286 ligand binding site [chemical binding]; other site 399741000287 NADP binding site [chemical binding]; other site 399741000288 catalytic site [active] 399741000289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741000290 D-galactonate transporter; Region: 2A0114; TIGR00893 399741000291 putative substrate translocation pore; other site 399741000292 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 399741000293 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 399741000294 substrate binding site [chemical binding]; other site 399741000295 ATP binding site [chemical binding]; other site 399741000296 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 399741000297 Transcriptional regulators [Transcription]; Region: PurR; COG1609 399741000298 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741000299 DNA binding site [nucleotide binding] 399741000300 domain linker motif; other site 399741000301 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 399741000302 putative dimerization interface [polypeptide binding]; other site 399741000303 putative ligand binding site [chemical binding]; other site 399741000304 putative outer membrane lipoprotein; Provisional; Region: PRK10510 399741000305 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 399741000306 ligand binding site [chemical binding]; other site 399741000307 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 399741000308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741000309 Coenzyme A binding pocket [chemical binding]; other site 399741000310 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 399741000311 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 399741000312 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 399741000313 active site 399741000314 oxyanion hole [active] 399741000315 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 399741000316 catalytic triad [active] 399741000317 Autotransporter beta-domain; Region: Autotransporter; cl17461 399741000318 Autoinducer binding domain; Region: Autoind_bind; pfam03472 399741000319 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741000320 DNA binding residues [nucleotide binding] 399741000321 dimerization interface [polypeptide binding]; other site 399741000322 Autoinducer synthetase; Region: Autoind_synth; pfam00765 399741000323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741000324 D-galactonate transporter; Region: 2A0114; TIGR00893 399741000325 putative substrate translocation pore; other site 399741000326 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 399741000327 dimer interface [polypeptide binding]; other site 399741000328 motif 1; other site 399741000329 active site 399741000330 motif 2; other site 399741000331 motif 3; other site 399741000332 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 399741000333 DALR anticodon binding domain; Region: DALR_1; pfam05746 399741000334 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 399741000335 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 399741000336 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 399741000337 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 399741000338 active site 399741000339 P-loop; other site 399741000340 phosphorylation site [posttranslational modification] 399741000341 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 399741000342 active site 399741000343 phosphorylation site [posttranslational modification] 399741000344 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 399741000345 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 399741000346 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 399741000347 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 399741000348 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 399741000349 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 399741000350 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 399741000351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741000352 DNA-binding site [nucleotide binding]; DNA binding site 399741000353 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741000354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741000355 homodimer interface [polypeptide binding]; other site 399741000356 catalytic residue [active] 399741000357 hypothetical protein; Provisional; Region: PRK11020 399741000358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741000359 S-adenosylmethionine binding site [chemical binding]; other site 399741000360 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 399741000361 MOSC domain; Region: MOSC; pfam03473 399741000362 3-alpha domain; Region: 3-alpha; pfam03475 399741000363 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 399741000364 dimerization interface [polypeptide binding]; other site 399741000365 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 399741000366 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 399741000367 dimer interface [polypeptide binding]; other site 399741000368 putative CheW interface [polypeptide binding]; other site 399741000369 superoxide dismutase; Provisional; Region: PRK10925 399741000370 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 399741000371 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 399741000372 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 399741000373 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 399741000374 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 399741000375 molybdopterin cofactor binding site; other site 399741000376 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 399741000377 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 399741000378 molybdopterin cofactor binding site; other site 399741000379 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 399741000380 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 399741000381 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 399741000382 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 399741000383 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 399741000384 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 399741000385 hypothetical protein; Provisional; Region: PRK11615 399741000386 putative glutathione S-transferase; Provisional; Region: PRK10357 399741000387 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 399741000388 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 399741000389 dimer interface [polypeptide binding]; other site 399741000390 N-terminal domain interface [polypeptide binding]; other site 399741000391 putative substrate binding pocket (H-site) [chemical binding]; other site 399741000392 selenocysteine synthase; Provisional; Region: PRK04311 399741000393 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 399741000394 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 399741000395 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 399741000396 catalytic residue [active] 399741000397 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 399741000398 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 399741000399 G1 box; other site 399741000400 putative GEF interaction site [polypeptide binding]; other site 399741000401 GTP/Mg2+ binding site [chemical binding]; other site 399741000402 Switch I region; other site 399741000403 G2 box; other site 399741000404 G3 box; other site 399741000405 Switch II region; other site 399741000406 G4 box; other site 399741000407 G5 box; other site 399741000408 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 399741000409 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 399741000410 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 399741000411 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 399741000412 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 399741000413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741000414 putative substrate translocation pore; other site 399741000415 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 399741000416 Acyltransferase family; Region: Acyl_transf_3; pfam01757 399741000417 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 399741000418 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 399741000419 conserved cys residue [active] 399741000420 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741000421 Isochorismatase family; Region: Isochorismatase; pfam00857 399741000422 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 399741000423 catalytic triad [active] 399741000424 conserved cis-peptide bond; other site 399741000425 putative deaminase; Validated; Region: PRK06846 399741000426 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 399741000427 active site 399741000428 xylulokinase; Provisional; Region: PRK15027 399741000429 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 399741000430 N- and C-terminal domain interface [polypeptide binding]; other site 399741000431 active site 399741000432 MgATP binding site [chemical binding]; other site 399741000433 catalytic site [active] 399741000434 metal binding site [ion binding]; metal-binding site 399741000435 xylulose binding site [chemical binding]; other site 399741000436 homodimer interface [polypeptide binding]; other site 399741000437 xylose isomerase; Provisional; Region: PRK05474 399741000438 xylose isomerase; Region: xylose_isom_A; TIGR02630 399741000439 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 399741000440 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 399741000441 putative ligand binding site [chemical binding]; other site 399741000442 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 399741000443 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 399741000444 Walker A/P-loop; other site 399741000445 ATP binding site [chemical binding]; other site 399741000446 Q-loop/lid; other site 399741000447 ABC transporter signature motif; other site 399741000448 Walker B; other site 399741000449 D-loop; other site 399741000450 H-loop/switch region; other site 399741000451 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 399741000452 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 399741000453 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 399741000454 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 399741000455 TM-ABC transporter signature motif; other site 399741000456 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 399741000457 putative dimerization interface [polypeptide binding]; other site 399741000458 Transcriptional regulators [Transcription]; Region: PurR; COG1609 399741000459 putative ligand binding site [chemical binding]; other site 399741000460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741000461 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 399741000462 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741000463 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 399741000464 dimerization interface [polypeptide binding]; other site 399741000465 putative DNA binding site [nucleotide binding]; other site 399741000466 putative Zn2+ binding site [ion binding]; other site 399741000467 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 399741000468 active site 399741000469 NTP binding site [chemical binding]; other site 399741000470 metal binding triad [ion binding]; metal-binding site 399741000471 antibiotic binding site [chemical binding]; other site 399741000472 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741000473 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741000474 dimerization interface [polypeptide binding]; other site 399741000475 putative cyanate transporter; Provisional; Region: cynX; PRK09705 399741000476 Herpesvirus U59 protein; Region: Herpes_U59; pfam04529 399741000477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 399741000478 integrase; Provisional; Region: PRK09692 399741000479 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 399741000480 active site 399741000481 Int/Topo IB signature motif; other site 399741000482 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 399741000483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741000484 AAA domain; Region: AAA_23; pfam13476 399741000485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741000486 AAA domain; Region: AAA_21; pfam13304 399741000487 Walker A/P-loop; other site 399741000488 Walker A/P-loop; other site 399741000489 ATP binding site [chemical binding]; other site 399741000490 ATP binding site [chemical binding]; other site 399741000491 AAA domain; Region: AAA_21; pfam13304 399741000492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741000493 ABC transporter signature motif; other site 399741000494 Walker B; other site 399741000495 D-loop; other site 399741000496 H-loop/switch region; other site 399741000497 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 399741000498 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741000499 DNA-binding site [nucleotide binding]; DNA binding site 399741000500 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741000501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741000502 homodimer interface [polypeptide binding]; other site 399741000503 catalytic residue [active] 399741000504 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 399741000505 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 399741000506 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 399741000507 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 399741000508 HlyD family secretion protein; Region: HlyD_3; pfam13437 399741000509 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741000510 DNA binding residues [nucleotide binding] 399741000511 dimerization interface [polypeptide binding]; other site 399741000512 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 399741000513 catalytic core [active] 399741000514 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 399741000515 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 399741000516 nucleotide binding site/active site [active] 399741000517 HIT family signature motif; other site 399741000518 catalytic residue [active] 399741000519 Transcriptional regulators [Transcription]; Region: PurR; COG1609 399741000520 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741000521 DNA binding site [nucleotide binding] 399741000522 domain linker motif; other site 399741000523 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 399741000524 putative dimerization interface [polypeptide binding]; other site 399741000525 putative ligand binding site [chemical binding]; other site 399741000526 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 399741000527 classical (c) SDRs; Region: SDR_c; cd05233 399741000528 NAD(P) binding site [chemical binding]; other site 399741000529 active site 399741000530 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 399741000531 DctM-like transporters; Region: DctM; pfam06808 399741000532 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 399741000533 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 399741000534 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 399741000535 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 399741000536 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 399741000537 extended (e) SDRs; Region: SDR_e; cd08946 399741000538 NAD(P) binding site [chemical binding]; other site 399741000539 active site 399741000540 substrate binding site [chemical binding]; other site 399741000541 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741000542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741000543 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 399741000544 dimerization interface [polypeptide binding]; other site 399741000545 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 399741000546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 399741000547 NAD(P) binding site [chemical binding]; other site 399741000548 active site 399741000549 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 399741000550 HD domain; Region: HD_4; pfam13328 399741000551 Transcriptional regulators [Transcription]; Region: MarR; COG1846 399741000552 MarR family; Region: MarR; pfam01047 399741000553 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 399741000554 phosphoethanolamine transferase; Provisional; Region: PRK11560 399741000555 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 399741000556 Sulfatase; Region: Sulfatase; pfam00884 399741000557 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 399741000558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741000559 active site 399741000560 phosphorylation site [posttranslational modification] 399741000561 intermolecular recognition site; other site 399741000562 dimerization interface [polypeptide binding]; other site 399741000563 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741000564 DNA binding residues [nucleotide binding] 399741000565 dimerization interface [polypeptide binding]; other site 399741000566 sensory histidine kinase UhpB; Provisional; Region: PRK11644 399741000567 MASE1; Region: MASE1; cl17823 399741000568 MASE1; Region: MASE1; cl17823 399741000569 Histidine kinase; Region: HisKA_3; pfam07730 399741000570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741000571 ATP binding site [chemical binding]; other site 399741000572 Mg2+ binding site [ion binding]; other site 399741000573 G-X-G motif; other site 399741000574 regulatory protein UhpC; Provisional; Region: PRK11663 399741000575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741000576 putative substrate translocation pore; other site 399741000577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741000578 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 399741000579 N-terminal Early set domain associated with the catalytic domain of chitinase; Region: E_set_Chitinase_N; cd02848 399741000580 Glyco_18 domain; Region: Glyco_18; smart00636 399741000581 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 399741000582 active site 399741000583 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 399741000584 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 399741000585 peptide binding site [polypeptide binding]; other site 399741000586 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 399741000587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741000588 dimer interface [polypeptide binding]; other site 399741000589 conserved gate region; other site 399741000590 putative PBP binding loops; other site 399741000591 ABC-ATPase subunit interface; other site 399741000592 dipeptide transporter; Provisional; Region: PRK10913 399741000593 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 399741000594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741000595 dimer interface [polypeptide binding]; other site 399741000596 conserved gate region; other site 399741000597 putative PBP binding loops; other site 399741000598 ABC-ATPase subunit interface; other site 399741000599 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 399741000600 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741000601 Walker A/P-loop; other site 399741000602 ATP binding site [chemical binding]; other site 399741000603 Q-loop/lid; other site 399741000604 ABC transporter signature motif; other site 399741000605 Walker B; other site 399741000606 D-loop; other site 399741000607 H-loop/switch region; other site 399741000608 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 399741000609 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 399741000610 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741000611 Walker A/P-loop; other site 399741000612 ATP binding site [chemical binding]; other site 399741000613 Q-loop/lid; other site 399741000614 ABC transporter signature motif; other site 399741000615 Walker B; other site 399741000616 D-loop; other site 399741000617 H-loop/switch region; other site 399741000618 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 399741000619 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 399741000620 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 399741000621 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 399741000622 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 399741000623 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 399741000624 YhjQ protein; Region: YhjQ; pfam06564 399741000625 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 399741000626 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 399741000627 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 399741000628 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 399741000629 DXD motif; other site 399741000630 PilZ domain; Region: PilZ; pfam07238 399741000631 cellulose synthase regulator protein; Provisional; Region: PRK11114 399741000632 endo-1,4-D-glucanase; Provisional; Region: PRK11097 399741000633 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 399741000634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 399741000635 TPR motif; other site 399741000636 binding surface 399741000637 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 399741000638 TPR motif; other site 399741000639 binding surface 399741000640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 399741000641 TPR motif; other site 399741000642 binding surface 399741000643 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 399741000644 putative diguanylate cyclase; Provisional; Region: PRK13561 399741000645 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 399741000646 metal binding site [ion binding]; metal-binding site 399741000647 active site 399741000648 I-site; other site 399741000649 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 399741000650 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 399741000651 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 399741000652 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 399741000653 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 399741000654 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 399741000655 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 399741000656 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 399741000657 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 399741000658 Part of AAA domain; Region: AAA_19; pfam13245 399741000659 Family description; Region: UvrD_C_2; pfam13538 399741000660 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 399741000661 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 399741000662 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 399741000663 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 399741000664 ATP binding site [chemical binding]; other site 399741000665 Mg++ binding site [ion binding]; other site 399741000666 motif III; other site 399741000667 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 399741000668 nucleotide binding region [chemical binding]; other site 399741000669 ATP-binding site [chemical binding]; other site 399741000670 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 399741000671 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 399741000672 catalytic residues [active] 399741000673 transcription termination factor Rho; Provisional; Region: rho; PRK09376 399741000674 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 399741000675 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 399741000676 RNA binding site [nucleotide binding]; other site 399741000677 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 399741000678 multimer interface [polypeptide binding]; other site 399741000679 Walker A motif; other site 399741000680 ATP binding site [chemical binding]; other site 399741000681 Walker B motif; other site 399741000682 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 399741000683 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 399741000684 Mg++ binding site [ion binding]; other site 399741000685 putative catalytic motif [active] 399741000686 substrate binding site [chemical binding]; other site 399741000687 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 399741000688 Chain length determinant protein; Region: Wzz; pfam02706 399741000689 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 399741000690 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 399741000691 active site 399741000692 homodimer interface [polypeptide binding]; other site 399741000693 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 399741000694 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 399741000695 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 399741000696 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 399741000697 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 399741000698 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 399741000699 NAD binding site [chemical binding]; other site 399741000700 substrate binding site [chemical binding]; other site 399741000701 homodimer interface [polypeptide binding]; other site 399741000702 active site 399741000703 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 399741000704 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 399741000705 substrate binding site; other site 399741000706 tetramer interface; other site 399741000707 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 399741000708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741000709 Coenzyme A binding pocket [chemical binding]; other site 399741000710 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 399741000711 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 399741000712 inhibitor-cofactor binding pocket; inhibition site 399741000713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741000714 catalytic residue [active] 399741000715 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 399741000716 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 399741000717 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 399741000718 putative common antigen polymerase; Provisional; Region: PRK02975 399741000719 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 399741000720 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 399741000721 putative transport protein YifK; Provisional; Region: PRK10746 399741000722 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 399741000723 HemY protein N-terminus; Region: HemY_N; pfam07219 399741000724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 399741000725 TPR motif; other site 399741000726 binding surface 399741000727 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 399741000728 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 399741000729 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 399741000730 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 399741000731 active site 399741000732 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 399741000733 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 399741000734 domain interfaces; other site 399741000735 active site 399741000736 adenylate cyclase; Provisional; Region: cyaA; PRK09450 399741000737 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 399741000738 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 399741000739 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 399741000740 putative iron binding site [ion binding]; other site 399741000741 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 399741000742 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 399741000743 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 399741000744 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 399741000745 hypothetical protein; Provisional; Region: PRK10963 399741000746 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 399741000747 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 399741000748 active site 399741000749 DNA binding site [nucleotide binding] 399741000750 Int/Topo IB signature motif; other site 399741000751 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 399741000752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741000753 motif II; other site 399741000754 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 399741000755 Part of AAA domain; Region: AAA_19; pfam13245 399741000756 Family description; Region: UvrD_C_2; pfam13538 399741000757 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 399741000758 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 399741000759 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 399741000760 oligomer interface [polypeptide binding]; other site 399741000761 Cl binding site [ion binding]; other site 399741000762 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 399741000763 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 399741000764 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 399741000765 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 399741000766 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 399741000767 CoenzymeA binding site [chemical binding]; other site 399741000768 subunit interaction site [polypeptide binding]; other site 399741000769 PHB binding site; other site 399741000770 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 399741000771 dimerization interface [polypeptide binding]; other site 399741000772 substrate binding site [chemical binding]; other site 399741000773 active site 399741000774 calcium binding site [ion binding]; other site 399741000775 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 399741000776 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 399741000777 ATP binding site [chemical binding]; other site 399741000778 putative Mg++ binding site [ion binding]; other site 399741000779 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 399741000780 nucleotide binding region [chemical binding]; other site 399741000781 ATP-binding site [chemical binding]; other site 399741000782 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 399741000783 HRDC domain; Region: HRDC; pfam00570 399741000784 threonine efflux system; Provisional; Region: PRK10229 399741000785 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 399741000786 lysophospholipase L2; Provisional; Region: PRK10749 399741000787 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 399741000788 putative hydrolase; Provisional; Region: PRK10976 399741000789 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741000790 active site 399741000791 motif I; other site 399741000792 motif II; other site 399741000793 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741000794 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 399741000795 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 399741000796 active site 399741000797 catalytic site [active] 399741000798 metal binding site [ion binding]; metal-binding site 399741000799 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 399741000800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741000801 putative substrate translocation pore; other site 399741000802 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 399741000803 hydroxyglutarate oxidase; Provisional; Region: PRK11728 399741000804 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 399741000805 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 399741000806 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 399741000807 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 399741000808 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 399741000809 Cysteine-rich domain; Region: CCG; pfam02754 399741000810 Cysteine-rich domain; Region: CCG; pfam02754 399741000811 hypothetical protein; Provisional; Region: PRK11615 399741000812 hypothetical protein; Provisional; Region: PRK11212 399741000813 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 399741000814 CPxP motif; other site 399741000815 Protein of unknown function (DUF4056); Region: DUF4056; pfam13265 399741000816 Surface antigen; Region: Bac_surface_Ag; pfam01103 399741000817 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 399741000818 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 399741000819 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 399741000820 metal-binding site [ion binding] 399741000821 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 399741000822 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 399741000823 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 399741000824 active site 399741000825 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 399741000826 Protease inhibitor Inh; Region: Inh; pfam02974 399741000827 Predicted membrane protein [Function unknown]; Region: COG3714 399741000828 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 399741000829 dimerization interface [polypeptide binding]; other site 399741000830 DNA binding residues [nucleotide binding] 399741000831 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 399741000832 DNA binding residues [nucleotide binding] 399741000833 dimerization interface [polypeptide binding]; other site 399741000834 CblD like pilus biogenesis initiator; Region: CblD; cl06460 399741000835 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 399741000836 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; pfam04449 399741000837 putative fimbrial protein TcfA; Provisional; Region: PRK15308 399741000838 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 399741000839 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 399741000840 active site 399741000841 DNA binding site [nucleotide binding] 399741000842 Int/Topo IB signature motif; other site 399741000843 hypothetical protein; Provisional; Region: PRK10910 399741000844 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 399741000845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741000846 S-adenosylmethionine binding site [chemical binding]; other site 399741000847 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 399741000848 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 399741000849 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 399741000850 P loop; other site 399741000851 GTP binding site [chemical binding]; other site 399741000852 cell division protein FtsE; Provisional; Region: PRK10908 399741000853 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741000854 Walker A/P-loop; other site 399741000855 ATP binding site [chemical binding]; other site 399741000856 Q-loop/lid; other site 399741000857 ABC transporter signature motif; other site 399741000858 Walker B; other site 399741000859 D-loop; other site 399741000860 H-loop/switch region; other site 399741000861 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 399741000862 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 399741000863 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 399741000864 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 399741000865 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 399741000866 DNA binding residues [nucleotide binding] 399741000867 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 399741000868 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 399741000869 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 399741000870 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 399741000871 dimerization interface [polypeptide binding]; other site 399741000872 ligand binding site [chemical binding]; other site 399741000873 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 399741000874 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 399741000875 TM-ABC transporter signature motif; other site 399741000876 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 399741000877 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 399741000878 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 399741000879 TM-ABC transporter signature motif; other site 399741000880 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 399741000881 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 399741000882 Walker A/P-loop; other site 399741000883 ATP binding site [chemical binding]; other site 399741000884 Q-loop/lid; other site 399741000885 ABC transporter signature motif; other site 399741000886 Walker B; other site 399741000887 D-loop; other site 399741000888 H-loop/switch region; other site 399741000889 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 399741000890 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 399741000891 Walker A/P-loop; other site 399741000892 ATP binding site [chemical binding]; other site 399741000893 Q-loop/lid; other site 399741000894 ABC transporter signature motif; other site 399741000895 Walker B; other site 399741000896 D-loop; other site 399741000897 H-loop/switch region; other site 399741000898 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 399741000899 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741000900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741000901 homodimer interface [polypeptide binding]; other site 399741000902 catalytic residue [active] 399741000903 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 399741000904 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 399741000905 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 399741000906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741000907 dimer interface [polypeptide binding]; other site 399741000908 conserved gate region; other site 399741000909 putative PBP binding loops; other site 399741000910 ABC-ATPase subunit interface; other site 399741000911 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 399741000912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741000913 dimer interface [polypeptide binding]; other site 399741000914 conserved gate region; other site 399741000915 putative PBP binding loops; other site 399741000916 ABC-ATPase subunit interface; other site 399741000917 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 399741000918 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 399741000919 Walker A/P-loop; other site 399741000920 ATP binding site [chemical binding]; other site 399741000921 Q-loop/lid; other site 399741000922 ABC transporter signature motif; other site 399741000923 Walker B; other site 399741000924 D-loop; other site 399741000925 H-loop/switch region; other site 399741000926 TOBE domain; Region: TOBE_2; pfam08402 399741000927 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 399741000928 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 399741000929 putative active site [active] 399741000930 catalytic site [active] 399741000931 putative metal binding site [ion binding]; other site 399741000932 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 399741000933 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 399741000934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741000935 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 399741000936 putative dimerization interface [polypeptide binding]; other site 399741000937 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 399741000938 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 399741000939 THF binding site; other site 399741000940 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 399741000941 substrate binding site [chemical binding]; other site 399741000942 THF binding site; other site 399741000943 zinc-binding site [ion binding]; other site 399741000944 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 399741000945 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 399741000946 uridine phosphorylase; Provisional; Region: PRK11178 399741000947 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 399741000948 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 399741000949 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 399741000950 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 399741000951 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 399741000952 DNA recombination protein RmuC; Provisional; Region: PRK10361 399741000953 RmuC family; Region: RmuC; pfam02646 399741000954 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 399741000955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741000956 S-adenosylmethionine binding site [chemical binding]; other site 399741000957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 399741000958 SCP-2 sterol transfer family; Region: SCP2; pfam02036 399741000959 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 399741000960 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 399741000961 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 399741000962 sec-independent translocase; Provisional; Region: PRK01770 399741000963 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 399741000964 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 399741000965 active site 399741000966 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 399741000967 dimer interface [polypeptide binding]; other site 399741000968 allosteric magnesium binding site [ion binding]; other site 399741000969 active site 399741000970 aspartate-rich active site metal binding site; other site 399741000971 Schiff base residues; other site 399741000972 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 399741000973 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 399741000974 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 399741000975 active site pocket [active] 399741000976 oxyanion hole [active] 399741000977 catalytic triad [active] 399741000978 active site nucleophile [active] 399741000979 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 399741000980 FMN reductase; Validated; Region: fre; PRK08051 399741000981 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 399741000982 FAD binding pocket [chemical binding]; other site 399741000983 FAD binding motif [chemical binding]; other site 399741000984 phosphate binding motif [ion binding]; other site 399741000985 beta-alpha-beta structure motif; other site 399741000986 NAD binding pocket [chemical binding]; other site 399741000987 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 399741000988 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 399741000989 dimer interface [polypeptide binding]; other site 399741000990 active site 399741000991 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 399741000992 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 399741000993 substrate binding site [chemical binding]; other site 399741000994 oxyanion hole (OAH) forming residues; other site 399741000995 trimer interface [polypeptide binding]; other site 399741000996 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 399741000997 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 399741000998 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 399741000999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741001000 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741001001 putative substrate translocation pore; other site 399741001002 proline dipeptidase; Provisional; Region: PRK13607 399741001003 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 399741001004 active site 399741001005 hypothetical protein; Provisional; Region: PRK11568 399741001006 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 399741001007 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 399741001008 potassium transporter; Provisional; Region: PRK10750 399741001009 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 399741001010 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 399741001011 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 399741001012 FAD binding domain; Region: FAD_binding_4; pfam01565 399741001013 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 399741001014 Biotin operon repressor [Transcription]; Region: BirA; COG1654 399741001015 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 399741001016 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 399741001017 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 399741001018 pantothenate kinase; Provisional; Region: PRK05439 399741001019 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 399741001020 ATP-binding site [chemical binding]; other site 399741001021 CoA-binding site [chemical binding]; other site 399741001022 Mg2+-binding site [ion binding]; other site 399741001023 elongation factor Tu; Reviewed; Region: PRK00049 399741001024 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 399741001025 G1 box; other site 399741001026 GEF interaction site [polypeptide binding]; other site 399741001027 GTP/Mg2+ binding site [chemical binding]; other site 399741001028 Switch I region; other site 399741001029 G2 box; other site 399741001030 G3 box; other site 399741001031 Switch II region; other site 399741001032 G4 box; other site 399741001033 G5 box; other site 399741001034 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 399741001035 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 399741001036 Antibiotic Binding Site [chemical binding]; other site 399741001037 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 399741001038 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 399741001039 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 399741001040 putative homodimer interface [polypeptide binding]; other site 399741001041 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 399741001042 heterodimer interface [polypeptide binding]; other site 399741001043 homodimer interface [polypeptide binding]; other site 399741001044 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 399741001045 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 399741001046 23S rRNA interface [nucleotide binding]; other site 399741001047 L7/L12 interface [polypeptide binding]; other site 399741001048 putative thiostrepton binding site; other site 399741001049 L25 interface [polypeptide binding]; other site 399741001050 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 399741001051 mRNA/rRNA interface [nucleotide binding]; other site 399741001052 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 399741001053 23S rRNA interface [nucleotide binding]; other site 399741001054 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 399741001055 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 399741001056 core dimer interface [polypeptide binding]; other site 399741001057 peripheral dimer interface [polypeptide binding]; other site 399741001058 L10 interface [polypeptide binding]; other site 399741001059 L11 interface [polypeptide binding]; other site 399741001060 putative EF-Tu interaction site [polypeptide binding]; other site 399741001061 putative EF-G interaction site [polypeptide binding]; other site 399741001062 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 399741001063 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 399741001064 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 399741001065 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 399741001066 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 399741001067 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 399741001068 RPB3 interaction site [polypeptide binding]; other site 399741001069 RPB1 interaction site [polypeptide binding]; other site 399741001070 RPB11 interaction site [polypeptide binding]; other site 399741001071 RPB10 interaction site [polypeptide binding]; other site 399741001072 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 399741001073 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 399741001074 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 399741001075 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 399741001076 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 399741001077 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 399741001078 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 399741001079 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 399741001080 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 399741001081 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 399741001082 DNA binding site [nucleotide binding] 399741001083 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 399741001084 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 399741001085 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 399741001086 FeS/SAM binding site; other site 399741001087 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 399741001088 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 399741001089 ThiS interaction site; other site 399741001090 putative active site [active] 399741001091 tetramer interface [polypeptide binding]; other site 399741001092 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 399741001093 thiS-thiF/thiG interaction site; other site 399741001094 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 399741001095 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 399741001096 ATP binding site [chemical binding]; other site 399741001097 substrate interface [chemical binding]; other site 399741001098 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 399741001099 thiamine phosphate binding site [chemical binding]; other site 399741001100 active site 399741001101 pyrophosphate binding site [ion binding]; other site 399741001102 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 399741001103 ThiC-associated domain; Region: ThiC-associated; pfam13667 399741001104 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 399741001105 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 399741001106 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 399741001107 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 399741001108 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 399741001109 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 399741001110 putative NADH binding site [chemical binding]; other site 399741001111 putative active site [active] 399741001112 nudix motif; other site 399741001113 putative metal binding site [ion binding]; other site 399741001114 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 399741001115 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 399741001116 substrate binding site [chemical binding]; other site 399741001117 active site 399741001118 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 399741001119 Active_site [active] 399741001120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 399741001121 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 399741001122 IHF dimer interface [polypeptide binding]; other site 399741001123 IHF - DNA interface [nucleotide binding]; other site 399741001124 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 399741001125 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 399741001126 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 399741001127 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 399741001128 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 399741001129 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 399741001130 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 399741001131 purine monophosphate binding site [chemical binding]; other site 399741001132 dimer interface [polypeptide binding]; other site 399741001133 putative catalytic residues [active] 399741001134 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 399741001135 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 399741001136 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 399741001137 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 399741001138 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 399741001139 Sulfatase; Region: Sulfatase; cl17466 399741001140 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 399741001141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 399741001142 Putative glucoamylase; Region: Glycoamylase; pfam10091 399741001143 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 399741001144 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 399741001145 Na binding site [ion binding]; other site 399741001146 Predicted membrane protein [Function unknown]; Region: COG3162 399741001147 acetyl-CoA synthetase; Provisional; Region: PRK00174 399741001148 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 399741001149 active site 399741001150 CoA binding site [chemical binding]; other site 399741001151 acyl-activating enzyme (AAE) consensus motif; other site 399741001152 AMP binding site [chemical binding]; other site 399741001153 acetate binding site [chemical binding]; other site 399741001154 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 399741001155 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 399741001156 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 399741001157 Peptidase family M23; Region: Peptidase_M23; pfam01551 399741001158 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 399741001159 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 399741001160 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 399741001161 replicative DNA helicase; Region: DnaB; TIGR00665 399741001162 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 399741001163 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 399741001164 Walker A motif; other site 399741001165 ATP binding site [chemical binding]; other site 399741001166 Walker B motif; other site 399741001167 DNA binding loops [nucleotide binding] 399741001168 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 399741001169 ParB-like nuclease domain; Region: ParBc; cl02129 399741001170 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 399741001171 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 399741001172 Helix-turn-helix domain; Region: HTH_36; pfam13730 399741001173 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 399741001174 conjugal transfer protein TraV; Provisional; Region: PRK13733 399741001175 DNA topoisomerase III; Provisional; Region: PRK07726 399741001176 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 399741001177 active site 399741001178 putative interdomain interaction site [polypeptide binding]; other site 399741001179 putative metal-binding site [ion binding]; other site 399741001180 putative nucleotide binding site [chemical binding]; other site 399741001181 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 399741001182 domain I; other site 399741001183 DNA binding groove [nucleotide binding] 399741001184 phosphate binding site [ion binding]; other site 399741001185 domain II; other site 399741001186 domain III; other site 399741001187 nucleotide binding site [chemical binding]; other site 399741001188 catalytic site [active] 399741001189 domain IV; other site 399741001190 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 399741001191 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 399741001192 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 399741001193 dimer interface [polypeptide binding]; other site 399741001194 ssDNA binding site [nucleotide binding]; other site 399741001195 tetramer (dimer of dimers) interface [polypeptide binding]; other site 399741001196 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741001197 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 399741001198 homodimer interface [polypeptide binding]; other site 399741001199 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741001200 non-specific DNA binding site [nucleotide binding]; other site 399741001201 salt bridge; other site 399741001202 sequence-specific DNA binding site [nucleotide binding]; other site 399741001203 Domain of unknown function (DUF955); Region: DUF955; pfam06114 399741001204 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 399741001205 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 399741001206 dimerization interface [polypeptide binding]; other site 399741001207 active site 399741001208 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 399741001209 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 399741001210 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 399741001211 N-acetyl-D-glucosamine binding site [chemical binding]; other site 399741001212 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 399741001213 Restriction endonuclease; Region: Mrr_cat; pfam04471 399741001214 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 399741001215 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 399741001216 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 399741001217 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 399741001218 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 399741001219 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 399741001220 Protein of unknown function (DUF2976); Region: DUF2976; pfam11190 399741001221 conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750 399741001222 Protein of unknown function (DUF2895); Region: DUF2895; pfam11444 399741001223 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 399741001224 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 399741001225 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 399741001226 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 399741001227 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 399741001228 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 399741001229 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 399741001230 dimer interface [polypeptide binding]; other site 399741001231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741001232 catalytic residue [active] 399741001233 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 399741001234 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 399741001235 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 399741001236 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 399741001237 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 399741001238 acyl-activating enzyme (AAE) consensus motif; other site 399741001239 AMP binding site [chemical binding]; other site 399741001240 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 399741001241 Thioesterase domain; Region: Thioesterase; pfam00975 399741001242 hypothetical protein; Provisional; Region: PRK07206 399741001243 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 399741001244 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 399741001245 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 399741001246 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 399741001247 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 399741001248 active site 399741001249 dimer interface [polypeptide binding]; other site 399741001250 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 399741001251 Ligand Binding Site [chemical binding]; other site 399741001252 Molecular Tunnel; other site 399741001253 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 399741001254 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 399741001255 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 399741001256 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 399741001257 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 399741001258 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 399741001259 Helix-turn-helix domain; Region: HTH_38; pfam13936 399741001260 Integrase core domain; Region: rve; pfam00665 399741001261 transposase/IS protein; Provisional; Region: PRK09183 399741001262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741001263 Walker A motif; other site 399741001264 ATP binding site [chemical binding]; other site 399741001265 Walker B motif; other site 399741001266 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 399741001267 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 399741001268 Transposase; Region: HTH_Tnp_1; pfam01527 399741001269 DinB family; Region: DinB; cl17821 399741001270 DinB superfamily; Region: DinB_2; pfam12867 399741001271 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 399741001272 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 399741001273 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741001274 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 399741001275 Paraquat-inducible protein A; Region: PqiA; pfam04403 399741001276 Paraquat-inducible protein A; Region: PqiA; pfam04403 399741001277 paraquat-inducible protein B; Provisional; Region: PRK10807 399741001278 mce related protein; Region: MCE; pfam02470 399741001279 mce related protein; Region: MCE; pfam02470 399741001280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 399741001281 Protein of unknown function (DUF330); Region: DUF330; pfam03886 399741001282 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 399741001283 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 399741001284 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 399741001285 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 399741001286 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 399741001287 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 399741001288 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 399741001289 substrate binding pocket [chemical binding]; other site 399741001290 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 399741001291 Transcriptional regulators [Transcription]; Region: MarR; COG1846 399741001292 MarR family; Region: MarR; pfam01047 399741001293 Transposase; Region: HTH_Tnp_1; pfam01527 399741001294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 399741001295 HTH-like domain; Region: HTH_21; pfam13276 399741001296 Integrase core domain; Region: rve; pfam00665 399741001297 Integrase core domain; Region: rve_3; pfam13683 399741001298 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 399741001299 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 399741001300 tetramer interface [polypeptide binding]; other site 399741001301 heme binding pocket [chemical binding]; other site 399741001302 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 399741001303 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 399741001304 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 399741001305 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 399741001306 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 399741001307 catalytic residues [active] 399741001308 catalytic nucleophile [active] 399741001309 Presynaptic Site I dimer interface [polypeptide binding]; other site 399741001310 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 399741001311 Synaptic Flat tetramer interface [polypeptide binding]; other site 399741001312 Synaptic Site I dimer interface [polypeptide binding]; other site 399741001313 DNA binding site [nucleotide binding] 399741001314 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 399741001315 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 399741001316 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 399741001317 Integrase core domain; Region: rve; pfam00665 399741001318 Integrase core domain; Region: rve_3; cl15866 399741001319 putative transposase OrfB; Reviewed; Region: PHA02517 399741001320 HTH-like domain; Region: HTH_21; pfam13276 399741001321 Integrase core domain; Region: rve; pfam00665 399741001322 Integrase core domain; Region: rve_3; pfam13683 399741001323 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 399741001324 Transposase; Region: HTH_Tnp_1; pfam01527 399741001325 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 399741001326 Integrase; Region: Integrase_1; pfam12835 399741001327 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 399741001328 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 399741001329 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 399741001330 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 399741001331 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 399741001332 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 399741001333 classical (c) SDRs; Region: SDR_c; cd05233 399741001334 NAD(P) binding site [chemical binding]; other site 399741001335 active site 399741001336 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 399741001337 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 399741001338 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 399741001339 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 399741001340 active site 399741001341 catalytic residues [active] 399741001342 DNA binding site [nucleotide binding] 399741001343 Int/Topo IB signature motif; other site 399741001344 putative transcriptional regulator; Provisional; Region: PRK11640 399741001345 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741001346 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 399741001347 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 399741001348 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 399741001349 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 399741001350 DsbD alpha interface [polypeptide binding]; other site 399741001351 catalytic residues [active] 399741001352 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 399741001353 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 399741001354 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 399741001355 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 399741001356 Aspartase; Region: Aspartase; cd01357 399741001357 active sites [active] 399741001358 tetramer interface [polypeptide binding]; other site 399741001359 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 399741001360 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 399741001361 oligomerisation interface [polypeptide binding]; other site 399741001362 mobile loop; other site 399741001363 roof hairpin; other site 399741001364 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 399741001365 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 399741001366 ring oligomerisation interface [polypeptide binding]; other site 399741001367 ATP/Mg binding site [chemical binding]; other site 399741001368 stacking interactions; other site 399741001369 hinge regions; other site 399741001370 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 399741001371 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 399741001372 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 399741001373 FeS/SAM binding site; other site 399741001374 elongation factor P; Validated; Region: PRK00529 399741001375 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 399741001376 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 399741001377 RNA binding site [nucleotide binding]; other site 399741001378 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 399741001379 RNA binding site [nucleotide binding]; other site 399741001380 entericidin A; Provisional; Region: PRK09810 399741001381 Predicted small secreted protein [Function unknown]; Region: COG5510 399741001382 multidrug efflux system protein; Provisional; Region: PRK11431 399741001383 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 399741001384 Iron-sulfur protein interface; other site 399741001385 proximal quinone binding site [chemical binding]; other site 399741001386 C-subunit interface; other site 399741001387 distal quinone binding site; other site 399741001388 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 399741001389 D-subunit interface [polypeptide binding]; other site 399741001390 Iron-sulfur protein interface; other site 399741001391 proximal quinone binding site [chemical binding]; other site 399741001392 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 399741001393 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 399741001394 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 399741001395 L-aspartate oxidase; Provisional; Region: PRK06175 399741001396 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 399741001397 poxB regulator PoxA; Provisional; Region: PRK09350 399741001398 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 399741001399 motif 1; other site 399741001400 dimer interface [polypeptide binding]; other site 399741001401 active site 399741001402 motif 2; other site 399741001403 motif 3; other site 399741001404 putative mechanosensitive channel protein; Provisional; Region: PRK10929 399741001405 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 399741001406 Mechanosensitive ion channel; Region: MS_channel; pfam00924 399741001407 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 399741001408 GTPase RsgA; Reviewed; Region: PRK12288 399741001409 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 399741001410 RNA binding site [nucleotide binding]; other site 399741001411 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 399741001412 GTPase/Zn-binding domain interface [polypeptide binding]; other site 399741001413 GTP/Mg2+ binding site [chemical binding]; other site 399741001414 G4 box; other site 399741001415 G5 box; other site 399741001416 G1 box; other site 399741001417 Switch I region; other site 399741001418 G2 box; other site 399741001419 G3 box; other site 399741001420 Switch II region; other site 399741001421 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 399741001422 catalytic site [active] 399741001423 putative active site [active] 399741001424 putative substrate binding site [chemical binding]; other site 399741001425 dimer interface [polypeptide binding]; other site 399741001426 epoxyqueuosine reductase; Region: TIGR00276 399741001427 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 399741001428 putative carbohydrate kinase; Provisional; Region: PRK10565 399741001429 Uncharacterized conserved protein [Function unknown]; Region: COG0062 399741001430 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 399741001431 putative substrate binding site [chemical binding]; other site 399741001432 putative ATP binding site [chemical binding]; other site 399741001433 ADP-binding protein; Provisional; Region: PRK10646 399741001434 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 399741001435 AMIN domain; Region: AMIN; pfam11741 399741001436 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 399741001437 active site 399741001438 metal binding site [ion binding]; metal-binding site 399741001439 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 399741001440 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 399741001441 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 399741001442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741001443 ATP binding site [chemical binding]; other site 399741001444 Mg2+ binding site [ion binding]; other site 399741001445 G-X-G motif; other site 399741001446 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 399741001447 ATP binding site [chemical binding]; other site 399741001448 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 399741001449 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 399741001450 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 399741001451 bacterial Hfq-like; Region: Hfq; cd01716 399741001452 hexamer interface [polypeptide binding]; other site 399741001453 Sm1 motif; other site 399741001454 RNA binding site [nucleotide binding]; other site 399741001455 Sm2 motif; other site 399741001456 GTPase HflX; Provisional; Region: PRK11058 399741001457 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 399741001458 HflX GTPase family; Region: HflX; cd01878 399741001459 G1 box; other site 399741001460 GTP/Mg2+ binding site [chemical binding]; other site 399741001461 Switch I region; other site 399741001462 G2 box; other site 399741001463 G3 box; other site 399741001464 Switch II region; other site 399741001465 G4 box; other site 399741001466 G5 box; other site 399741001467 FtsH protease regulator HflK; Provisional; Region: PRK10930 399741001468 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 399741001469 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 399741001470 FtsH protease regulator HflC; Provisional; Region: PRK11029 399741001471 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 399741001472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 399741001473 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 399741001474 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 399741001475 GDP-binding site [chemical binding]; other site 399741001476 ACT binding site; other site 399741001477 IMP binding site; other site 399741001478 Predicted transcriptional regulator [Transcription]; Region: COG1959 399741001479 transcriptional repressor NsrR; Provisional; Region: PRK11014 399741001480 exoribonuclease R; Provisional; Region: PRK11642 399741001481 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 399741001482 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 399741001483 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 399741001484 RNB domain; Region: RNB; pfam00773 399741001485 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 399741001486 RNA binding site [nucleotide binding]; other site 399741001487 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 399741001488 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 399741001489 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 399741001490 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 399741001491 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 399741001492 FAD binding site [chemical binding]; other site 399741001493 substrate binding site [chemical binding]; other site 399741001494 catalytic residues [active] 399741001495 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 399741001496 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 399741001497 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 399741001498 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 399741001499 esterase; Provisional; Region: PRK10566 399741001500 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 399741001501 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 399741001502 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 399741001503 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 399741001504 dimer interface [polypeptide binding]; other site 399741001505 ssDNA binding site [nucleotide binding]; other site 399741001506 tetramer (dimer of dimers) interface [polypeptide binding]; other site 399741001507 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 399741001508 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 399741001509 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 399741001510 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 399741001511 Protein of unknown function, DUF488; Region: DUF488; cl01246 399741001512 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 399741001513 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 399741001514 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 399741001515 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 399741001516 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 399741001517 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 399741001518 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 399741001519 active site 399741001520 metal binding site [ion binding]; metal-binding site 399741001521 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 399741001522 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 399741001523 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 399741001524 active site 399741001525 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 399741001526 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 399741001527 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 399741001528 Domain of unknown function DUF21; Region: DUF21; pfam01595 399741001529 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 399741001530 Transporter associated domain; Region: CorC_HlyC; smart01091 399741001531 methionine sulfoxide reductase A; Provisional; Region: PRK00058 399741001532 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 399741001533 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 399741001534 Surface antigen; Region: Bac_surface_Ag; pfam01103 399741001535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 399741001536 Family of unknown function (DUF490); Region: DUF490; pfam04357 399741001537 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 399741001538 dimerization interface [polypeptide binding]; other site 399741001539 putative active site pocket [active] 399741001540 putative catalytic residue [active] 399741001541 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 399741001542 dimer interface [polypeptide binding]; other site 399741001543 substrate binding site [chemical binding]; other site 399741001544 metal binding sites [ion binding]; metal-binding site 399741001545 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 399741001546 ligand binding site [chemical binding]; other site 399741001547 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 399741001548 dimerization interface [polypeptide binding]; other site 399741001549 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 399741001550 dimer interface [polypeptide binding]; other site 399741001551 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 399741001552 putative CheW interface [polypeptide binding]; other site 399741001553 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 399741001554 AMP binding site [chemical binding]; other site 399741001555 metal binding site [ion binding]; metal-binding site 399741001556 active site 399741001557 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 399741001558 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 399741001559 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 399741001560 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 399741001561 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 399741001562 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 399741001563 arginine repressor; Provisional; Region: PRK05066 399741001564 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 399741001565 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 399741001566 malate dehydrogenase; Provisional; Region: PRK05086 399741001567 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 399741001568 NAD binding site [chemical binding]; other site 399741001569 dimerization interface [polypeptide binding]; other site 399741001570 Substrate binding site [chemical binding]; other site 399741001571 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 399741001572 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 399741001573 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 399741001574 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 399741001575 substrate binding pocket [chemical binding]; other site 399741001576 chain length determination region; other site 399741001577 substrate-Mg2+ binding site; other site 399741001578 catalytic residues [active] 399741001579 aspartate-rich region 1; other site 399741001580 active site lid residues [active] 399741001581 aspartate-rich region 2; other site 399741001582 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 399741001583 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 399741001584 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 399741001585 EamA-like transporter family; Region: EamA; pfam00892 399741001586 EamA-like transporter family; Region: EamA; pfam00892 399741001587 GTPase CgtA; Reviewed; Region: obgE; PRK12298 399741001588 GTP1/OBG; Region: GTP1_OBG; pfam01018 399741001589 Obg GTPase; Region: Obg; cd01898 399741001590 G1 box; other site 399741001591 GTP/Mg2+ binding site [chemical binding]; other site 399741001592 Switch I region; other site 399741001593 G2 box; other site 399741001594 G3 box; other site 399741001595 Switch II region; other site 399741001596 G4 box; other site 399741001597 G5 box; other site 399741001598 sensor protein BasS/PmrB; Provisional; Region: PRK10755 399741001599 HAMP domain; Region: HAMP; pfam00672 399741001600 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741001601 dimer interface [polypeptide binding]; other site 399741001602 phosphorylation site [posttranslational modification] 399741001603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741001604 ATP binding site [chemical binding]; other site 399741001605 Mg2+ binding site [ion binding]; other site 399741001606 G-X-G motif; other site 399741001607 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 399741001608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741001609 active site 399741001610 phosphorylation site [posttranslational modification] 399741001611 intermolecular recognition site; other site 399741001612 dimerization interface [polypeptide binding]; other site 399741001613 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741001614 DNA binding site [nucleotide binding] 399741001615 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 399741001616 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 399741001617 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 399741001618 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 399741001619 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 399741001620 RNA-binding protein YhbY; Provisional; Region: PRK10343 399741001621 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 399741001622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741001623 S-adenosylmethionine binding site [chemical binding]; other site 399741001624 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 399741001625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741001626 Walker A motif; other site 399741001627 ATP binding site [chemical binding]; other site 399741001628 Walker B motif; other site 399741001629 arginine finger; other site 399741001630 Peptidase family M41; Region: Peptidase_M41; pfam01434 399741001631 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 399741001632 dihydropteroate synthase; Region: DHPS; TIGR01496 399741001633 substrate binding pocket [chemical binding]; other site 399741001634 dimer interface [polypeptide binding]; other site 399741001635 inhibitor binding site; inhibition site 399741001636 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 399741001637 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 399741001638 active site 399741001639 substrate binding site [chemical binding]; other site 399741001640 metal binding site [ion binding]; metal-binding site 399741001641 Preprotein translocase SecG subunit; Region: SecG; pfam03840 399741001642 ribosome maturation protein RimP; Reviewed; Region: PRK00092 399741001643 Sm and related proteins; Region: Sm_like; cl00259 399741001644 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 399741001645 putative oligomer interface [polypeptide binding]; other site 399741001646 putative RNA binding site [nucleotide binding]; other site 399741001647 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 399741001648 NusA N-terminal domain; Region: NusA_N; pfam08529 399741001649 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 399741001650 RNA binding site [nucleotide binding]; other site 399741001651 homodimer interface [polypeptide binding]; other site 399741001652 NusA-like KH domain; Region: KH_5; pfam13184 399741001653 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 399741001654 G-X-X-G motif; other site 399741001655 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 399741001656 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 399741001657 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 399741001658 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 399741001659 translation initiation factor IF-2; Region: IF-2; TIGR00487 399741001660 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 399741001661 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 399741001662 G1 box; other site 399741001663 putative GEF interaction site [polypeptide binding]; other site 399741001664 GTP/Mg2+ binding site [chemical binding]; other site 399741001665 Switch I region; other site 399741001666 G2 box; other site 399741001667 G3 box; other site 399741001668 Switch II region; other site 399741001669 G4 box; other site 399741001670 G5 box; other site 399741001671 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 399741001672 Translation-initiation factor 2; Region: IF-2; pfam11987 399741001673 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 399741001674 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 399741001675 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 399741001676 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 399741001677 RNA binding site [nucleotide binding]; other site 399741001678 active site 399741001679 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 399741001680 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 399741001681 16S/18S rRNA binding site [nucleotide binding]; other site 399741001682 S13e-L30e interaction site [polypeptide binding]; other site 399741001683 25S rRNA binding site [nucleotide binding]; other site 399741001684 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 399741001685 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 399741001686 RNase E interface [polypeptide binding]; other site 399741001687 trimer interface [polypeptide binding]; other site 399741001688 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 399741001689 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 399741001690 RNase E interface [polypeptide binding]; other site 399741001691 trimer interface [polypeptide binding]; other site 399741001692 active site 399741001693 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 399741001694 putative nucleic acid binding region [nucleotide binding]; other site 399741001695 G-X-X-G motif; other site 399741001696 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 399741001697 RNA binding site [nucleotide binding]; other site 399741001698 domain interface; other site 399741001699 lipoprotein NlpI; Provisional; Region: PRK11189 399741001700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 399741001701 binding surface 399741001702 TPR motif; other site 399741001703 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 399741001704 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 399741001705 ATP binding site [chemical binding]; other site 399741001706 Mg++ binding site [ion binding]; other site 399741001707 motif III; other site 399741001708 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 399741001709 nucleotide binding region [chemical binding]; other site 399741001710 ATP-binding site [chemical binding]; other site 399741001711 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 399741001712 putative RNA binding site [nucleotide binding]; other site 399741001713 Cold shock protein DEAD box A; Region: DEADboxA; pfam12343 399741001714 putative inner membrane protein; Provisional; Region: PRK11099 399741001715 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 399741001716 CPxP motif; other site 399741001717 hypothetical protein; Provisional; Region: PRK10508 399741001718 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 399741001719 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 399741001720 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 399741001721 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 399741001722 HlyD family secretion protein; Region: HlyD_3; pfam13437 399741001723 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 399741001724 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 399741001725 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 399741001726 ABC-2 type transporter; Region: ABC2_membrane; cl17235 399741001727 Uncharacterized conserved protein [Function unknown]; Region: COG2850 399741001728 putative protease; Provisional; Region: PRK15447 399741001729 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 399741001730 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 399741001731 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 399741001732 Peptidase family U32; Region: Peptidase_U32; pfam01136 399741001733 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 399741001734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741001735 Coenzyme A binding pocket [chemical binding]; other site 399741001736 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 399741001737 GIY-YIG motif/motif A; other site 399741001738 putative active site [active] 399741001739 putative metal binding site [ion binding]; other site 399741001740 putrescine transporter; Provisional; Region: potE; PRK10655 399741001741 ornithine decarboxylase; Provisional; Region: PRK13578 399741001742 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 399741001743 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 399741001744 homodimer interface [polypeptide binding]; other site 399741001745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741001746 catalytic residue [active] 399741001747 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 399741001748 hypothetical protein; Provisional; Region: PRK03467 399741001749 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 399741001750 NADH(P)-binding; Region: NAD_binding_10; pfam13460 399741001751 NAD binding site [chemical binding]; other site 399741001752 active site 399741001753 putative hydrolase; Provisional; Region: PRK02113 399741001754 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 399741001755 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 399741001756 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 399741001757 trimer interface [polypeptide binding]; other site 399741001758 active site 399741001759 substrate binding site [chemical binding]; other site 399741001760 CoA binding site [chemical binding]; other site 399741001761 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 399741001762 AAA domain; Region: AAA_18; pfam13238 399741001763 active site 399741001764 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 399741001765 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 399741001766 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 399741001767 active site 399741001768 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 399741001769 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 399741001770 Walker A/P-loop; other site 399741001771 ATP binding site [chemical binding]; other site 399741001772 Q-loop/lid; other site 399741001773 ABC transporter signature motif; other site 399741001774 Walker B; other site 399741001775 D-loop; other site 399741001776 H-loop/switch region; other site 399741001777 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 399741001778 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741001779 Walker A/P-loop; other site 399741001780 ATP binding site [chemical binding]; other site 399741001781 Q-loop/lid; other site 399741001782 ABC transporter signature motif; other site 399741001783 Walker B; other site 399741001784 D-loop; other site 399741001785 H-loop/switch region; other site 399741001786 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 399741001787 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 399741001788 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 399741001789 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 399741001790 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 399741001791 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 399741001792 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741001793 DNA-binding site [nucleotide binding]; DNA binding site 399741001794 UTRA domain; Region: UTRA; pfam07702 399741001795 Predicted permease; Region: DUF318; pfam03773 399741001796 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 399741001797 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 399741001798 FeS/SAM binding site; other site 399741001799 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 399741001800 ATP cone domain; Region: ATP-cone; pfam03477 399741001801 Class III ribonucleotide reductase; Region: RNR_III; cd01675 399741001802 effector binding site; other site 399741001803 active site 399741001804 Zn binding site [ion binding]; other site 399741001805 glycine loop; other site 399741001806 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741001807 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741001808 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 399741001809 putative effector binding pocket; other site 399741001810 dimerization interface [polypeptide binding]; other site 399741001811 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 399741001812 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 399741001813 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 399741001814 Ca binding site [ion binding]; other site 399741001815 active site 399741001816 catalytic site [active] 399741001817 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 399741001818 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 399741001819 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 399741001820 active site turn [active] 399741001821 phosphorylation site [posttranslational modification] 399741001822 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 399741001823 Bacterial self-protective colicin-like immunity; Region: Colicin_immun; pfam09204 399741001824 S-type Pyocin; Region: Pyocin_S; pfam06958 399741001825 Colicin D; Region: Colicin_D; pfam11429 399741001826 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 399741001827 trehalose repressor; Provisional; Region: treR; PRK09492 399741001828 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741001829 DNA binding site [nucleotide binding] 399741001830 domain linker motif; other site 399741001831 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 399741001832 dimerization interface [polypeptide binding]; other site 399741001833 ligand binding site [chemical binding]; other site 399741001834 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 399741001835 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 399741001836 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 399741001837 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 399741001838 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 399741001839 Soluble P-type ATPase [General function prediction only]; Region: COG4087 399741001840 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 399741001841 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 399741001842 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 399741001843 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 399741001844 active site 399741001845 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 399741001846 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 399741001847 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 399741001848 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 399741001849 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 399741001850 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 399741001851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 399741001852 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 399741001853 Uncharacterized conserved protein [Function unknown]; Region: COG2308 399741001854 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 399741001855 homotrimer interaction site [polypeptide binding]; other site 399741001856 putative active site [active] 399741001857 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 399741001858 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 399741001859 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 399741001860 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 399741001861 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 399741001862 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 399741001863 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 399741001864 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 399741001865 ABC-ATPase subunit interface; other site 399741001866 dimer interface [polypeptide binding]; other site 399741001867 putative PBP binding regions; other site 399741001868 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 399741001869 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 399741001870 putative ligand binding residues [chemical binding]; other site 399741001871 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 399741001872 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 399741001873 Walker A/P-loop; other site 399741001874 ATP binding site [chemical binding]; other site 399741001875 Q-loop/lid; other site 399741001876 ABC transporter signature motif; other site 399741001877 Walker B; other site 399741001878 D-loop; other site 399741001879 H-loop/switch region; other site 399741001880 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 399741001881 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 399741001882 dimer interface [polypeptide binding]; other site 399741001883 active site 399741001884 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 399741001885 substrate binding site [chemical binding]; other site 399741001886 catalytic residue [active] 399741001887 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 399741001888 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 399741001889 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 399741001890 putative active site [active] 399741001891 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 399741001892 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 399741001893 active site 399741001894 putative substrate binding pocket [chemical binding]; other site 399741001895 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 399741001896 homotrimer interaction site [polypeptide binding]; other site 399741001897 putative active site [active] 399741001898 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 399741001899 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 399741001900 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 399741001901 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 399741001902 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 399741001903 RNase E inhibitor protein; Provisional; Region: PRK11191 399741001904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 399741001905 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 399741001906 active site 399741001907 dinuclear metal binding site [ion binding]; other site 399741001908 dimerization interface [polypeptide binding]; other site 399741001909 choline dehydrogenase; Validated; Region: PRK02106 399741001910 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 399741001911 Acyltransferase family; Region: Acyl_transf_3; pfam01757 399741001912 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 399741001913 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741001914 Coenzyme A binding pocket [chemical binding]; other site 399741001915 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 399741001916 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 399741001917 HIGH motif; other site 399741001918 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 399741001919 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 399741001920 active site 399741001921 KMSKS motif; other site 399741001922 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 399741001923 tRNA binding surface [nucleotide binding]; other site 399741001924 anticodon binding site; other site 399741001925 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 399741001926 DNA polymerase III subunit chi; Validated; Region: PRK05728 399741001927 multifunctional aminopeptidase A; Provisional; Region: PRK00913 399741001928 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 399741001929 interface (dimer of trimers) [polypeptide binding]; other site 399741001930 Substrate-binding/catalytic site; other site 399741001931 Zn-binding sites [ion binding]; other site 399741001932 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 399741001933 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 399741001934 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 399741001935 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 399741001936 Fic family protein [Function unknown]; Region: COG3177 399741001937 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 399741001938 Fic/DOC family; Region: Fic; pfam02661 399741001939 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 399741001940 active site clefts [active] 399741001941 zinc binding site [ion binding]; other site 399741001942 dimer interface [polypeptide binding]; other site 399741001943 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 399741001944 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741001945 non-specific DNA binding site [nucleotide binding]; other site 399741001946 salt bridge; other site 399741001947 sequence-specific DNA binding site [nucleotide binding]; other site 399741001948 HipA N-terminal domain; Region: Couple_hipA; pfam13657 399741001949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741001950 active site 399741001951 phosphorylation site [posttranslational modification] 399741001952 intermolecular recognition site; other site 399741001953 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 399741001954 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 399741001955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741001956 ATP binding site [chemical binding]; other site 399741001957 Mg2+ binding site [ion binding]; other site 399741001958 G-X-G motif; other site 399741001959 N-terminal domain of type IIE restriction endonuclease EcoRII and similar proteins; Region: EcoRII_N; cd10016 399741001960 DNA binding site [nucleotide binding] 399741001961 EcoRII C terminal; Region: EcoRII-C; pfam09019 399741001962 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 399741001963 additional DNA contacts [nucleotide binding]; other site 399741001964 mismatch recognition site; other site 399741001965 active site 399741001966 zinc binding site [ion binding]; other site 399741001967 DNA intercalation site [nucleotide binding]; other site 399741001968 DNA cytosine methylase; Provisional; Region: PRK10458 399741001969 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 399741001970 cofactor binding site; other site 399741001971 DNA binding site [nucleotide binding] 399741001972 substrate interaction site [chemical binding]; other site 399741001973 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 399741001974 beta-galactosidase; Region: BGL; TIGR03356 399741001975 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 399741001976 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 399741001977 active site turn [active] 399741001978 phosphorylation site [posttranslational modification] 399741001979 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 399741001980 Transcriptional regulators [Transcription]; Region: PurR; COG1609 399741001981 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741001982 DNA binding site [nucleotide binding] 399741001983 domain linker motif; other site 399741001984 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 399741001985 dimerization interface (closed form) [polypeptide binding]; other site 399741001986 ligand binding site [chemical binding]; other site 399741001987 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 399741001988 Helix-turn-helix domain; Region: HTH_18; pfam12833 399741001989 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741001990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741001991 putative substrate translocation pore; other site 399741001992 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 399741001993 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 399741001994 P-loop, Walker A motif; other site 399741001995 Base recognition motif; other site 399741001996 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 399741001997 Uncharacterized small protein [Function unknown]; Region: COG2879 399741001998 carbon starvation protein A; Provisional; Region: PRK15015 399741001999 Carbon starvation protein CstA; Region: CstA; pfam02554 399741002000 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 399741002001 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 399741002002 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 399741002003 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 399741002004 PQQ-like domain; Region: PQQ_2; pfam13360 399741002005 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 399741002006 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 399741002007 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741002008 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741002009 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 399741002010 putative dimerization interface [polypeptide binding]; other site 399741002011 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 399741002012 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 399741002013 putative acyltransferase; Provisional; Region: PRK05790 399741002014 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 399741002015 dimer interface [polypeptide binding]; other site 399741002016 active site 399741002017 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 399741002018 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 399741002019 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 399741002020 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 399741002021 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 399741002022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 399741002023 NAD(P) binding site [chemical binding]; other site 399741002024 active site 399741002025 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 399741002026 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 399741002027 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741002028 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 399741002029 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741002030 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741002031 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 399741002032 L,D-transpeptidase; Provisional; Region: PRK10260 399741002033 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 399741002034 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 399741002035 Uncharacterized conserved protein [Function unknown]; Region: COG5464 399741002036 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 399741002037 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 399741002038 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 399741002039 Gram-negative bacterial tonB protein; Region: TonB; cl10048 399741002040 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 399741002041 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 399741002042 N-terminal plug; other site 399741002043 ligand-binding site [chemical binding]; other site 399741002044 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 399741002045 Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_1; cd09106 399741002046 PLD-like domain; Region: PLDc_2; pfam13091 399741002047 putative active site [active] 399741002048 putative catalytic site [active] 399741002049 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 399741002050 PLD-like domain; Region: PLDc_2; pfam13091 399741002051 putative active site [active] 399741002052 putative catalytic site [active] 399741002053 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 399741002054 homodimer interface [polypeptide binding]; other site 399741002055 homotetramer interface [polypeptide binding]; other site 399741002056 active site pocket [active] 399741002057 cleavage site 399741002058 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 399741002059 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 399741002060 tetrameric interface [polypeptide binding]; other site 399741002061 NAD binding site [chemical binding]; other site 399741002062 catalytic residues [active] 399741002063 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 399741002064 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 399741002065 inhibitor-cofactor binding pocket; inhibition site 399741002066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741002067 catalytic residue [active] 399741002068 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741002069 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741002070 LysR substrate binding domain; Region: LysR_substrate; pfam03466 399741002071 dimerization interface [polypeptide binding]; other site 399741002072 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 399741002073 Transposase; Region: HTH_Tnp_1; pfam01527 399741002074 putative transposase OrfB; Reviewed; Region: PHA02517 399741002075 HTH-like domain; Region: HTH_21; pfam13276 399741002076 Integrase core domain; Region: rve; pfam00665 399741002077 Integrase core domain; Region: rve_3; pfam13683 399741002078 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 399741002079 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 399741002080 active site 399741002081 NAD binding site [chemical binding]; other site 399741002082 metal binding site [ion binding]; metal-binding site 399741002083 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 399741002084 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741002085 DNA binding residues [nucleotide binding] 399741002086 dimerization interface [polypeptide binding]; other site 399741002087 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 399741002088 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 399741002089 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 399741002090 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 399741002091 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 399741002092 PGAP1-like protein; Region: PGAP1; pfam07819 399741002093 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 399741002094 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 399741002095 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 399741002096 active site 399741002097 Zn binding site [ion binding]; other site 399741002098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741002099 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 399741002100 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741002101 DNA binding residues [nucleotide binding] 399741002102 dimerization interface [polypeptide binding]; other site 399741002103 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 399741002104 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 399741002105 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 399741002106 classical (c) SDRs; Region: SDR_c; cd05233 399741002107 NAD(P) binding site [chemical binding]; other site 399741002108 active site 399741002109 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 399741002110 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 399741002111 classical (c) SDRs; Region: SDR_c; cd05233 399741002112 NAD(P) binding site [chemical binding]; other site 399741002113 active site 399741002114 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 399741002115 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 399741002116 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 399741002117 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 399741002118 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 399741002119 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 399741002120 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 399741002121 NAD binding site [chemical binding]; other site 399741002122 catalytic residues [active] 399741002123 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 399741002124 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 399741002125 putative active site [active] 399741002126 putative metal binding site [ion binding]; other site 399741002127 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 399741002128 putative substrate binding pocket [chemical binding]; other site 399741002129 trimer interface [polypeptide binding]; other site 399741002130 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 399741002131 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 399741002132 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 399741002133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741002134 putative substrate translocation pore; other site 399741002135 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 399741002136 Cupin domain; Region: Cupin_2; pfam07883 399741002137 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741002138 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 399741002139 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 399741002140 Flavin Reductases; Region: FlaRed; cl00801 399741002141 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 399741002142 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 399741002143 Transcriptional regulators [Transcription]; Region: FadR; COG2186 399741002144 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741002145 DNA-binding site [nucleotide binding]; DNA binding site 399741002146 FCD domain; Region: FCD; pfam07729 399741002147 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 399741002148 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 399741002149 NAD binding site [chemical binding]; other site 399741002150 homotetramer interface [polypeptide binding]; other site 399741002151 homodimer interface [polypeptide binding]; other site 399741002152 active site 399741002153 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 399741002154 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 399741002155 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 399741002156 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 399741002157 putative active site pocket [active] 399741002158 metal binding site [ion binding]; metal-binding site 399741002159 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 399741002160 Amidohydrolase; Region: Amidohydro_2; pfam04909 399741002161 short chain dehydrogenase; Provisional; Region: PRK08628 399741002162 classical (c) SDRs; Region: SDR_c; cd05233 399741002163 NAD(P) binding site [chemical binding]; other site 399741002164 active site 399741002165 Domain of unknown function (DUF718); Region: DUF718; pfam05336 399741002166 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 399741002167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741002168 putative substrate translocation pore; other site 399741002169 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 399741002170 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 399741002171 metal binding site [ion binding]; metal-binding site 399741002172 active site 399741002173 I-site; other site 399741002174 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 399741002175 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741002176 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741002177 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 399741002178 putative effector binding pocket; other site 399741002179 putative dimerization interface [polypeptide binding]; other site 399741002180 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 399741002181 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 399741002182 active site 399741002183 catalytic tetrad [active] 399741002184 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 399741002185 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 399741002186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741002187 S-adenosylmethionine binding site [chemical binding]; other site 399741002188 DNA polymerase III subunit psi; Validated; Region: PRK06856 399741002189 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 399741002190 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741002191 Coenzyme A binding pocket [chemical binding]; other site 399741002192 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 399741002193 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 399741002194 G1 box; other site 399741002195 putative GEF interaction site [polypeptide binding]; other site 399741002196 GTP/Mg2+ binding site [chemical binding]; other site 399741002197 Switch I region; other site 399741002198 G2 box; other site 399741002199 G3 box; other site 399741002200 Switch II region; other site 399741002201 G4 box; other site 399741002202 G5 box; other site 399741002203 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 399741002204 periplasmic protein; Provisional; Region: PRK10568 399741002205 BON domain; Region: BON; pfam04972 399741002206 BON domain; Region: BON; pfam04972 399741002207 CsbD-like; Region: CsbD; cl17424 399741002208 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 399741002209 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 399741002210 active site 399741002211 nucleophile elbow; other site 399741002212 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 399741002213 active site 399741002214 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 399741002215 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 399741002216 active site 399741002217 metal binding site [ion binding]; metal-binding site 399741002218 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 399741002219 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 399741002220 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 399741002221 Nucleoside recognition; Region: Gate; pfam07670 399741002222 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 399741002223 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 399741002224 intersubunit interface [polypeptide binding]; other site 399741002225 active site 399741002226 catalytic residue [active] 399741002227 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 399741002228 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 399741002229 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 399741002230 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 399741002231 phosphopentomutase; Provisional; Region: PRK05362 399741002232 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 399741002233 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 399741002234 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 399741002235 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 399741002236 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 399741002237 putative DNA binding site [nucleotide binding]; other site 399741002238 putative Zn2+ binding site [ion binding]; other site 399741002239 HipA-like N-terminal domain; Region: HipA_N; pfam07805 399741002240 HipA-like C-terminal domain; Region: HipA_C; pfam07804 399741002241 hypothetical protein; Provisional; Region: PRK11246 399741002242 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 399741002243 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741002244 motif I; other site 399741002245 motif II; other site 399741002246 DNA repair protein RadA; Region: sms; TIGR00416 399741002247 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 399741002248 Walker A motif/ATP binding site; other site 399741002249 ATP binding site [chemical binding]; other site 399741002250 Walker B motif; other site 399741002251 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 399741002252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741002253 non-specific DNA binding site [nucleotide binding]; other site 399741002254 salt bridge; other site 399741002255 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 399741002256 sequence-specific DNA binding site [nucleotide binding]; other site 399741002257 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 399741002258 active site 399741002259 nucleotide binding site [chemical binding]; other site 399741002260 HIGH motif; other site 399741002261 KMSKS motif; other site 399741002262 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 399741002263 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 399741002264 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 399741002265 putative NAD(P) binding site [chemical binding]; other site 399741002266 dimer interface [polypeptide binding]; other site 399741002267 LysR family transcriptional regulator; Provisional; Region: PRK14997 399741002268 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741002269 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 399741002270 putative effector binding pocket; other site 399741002271 dimerization interface [polypeptide binding]; other site 399741002272 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 399741002273 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741002274 Walker A/P-loop; other site 399741002275 ATP binding site [chemical binding]; other site 399741002276 Q-loop/lid; other site 399741002277 ABC transporter signature motif; other site 399741002278 Walker B; other site 399741002279 D-loop; other site 399741002280 H-loop/switch region; other site 399741002281 ABC transporter; Region: ABC_tran_2; pfam12848 399741002282 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 399741002283 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 399741002284 ligand binding site [chemical binding]; other site 399741002285 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 399741002286 HAMP domain; Region: HAMP; pfam00672 399741002287 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 399741002288 metal binding site [ion binding]; metal-binding site 399741002289 active site 399741002290 I-site; other site 399741002291 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 399741002292 lytic murein transglycosylase; Provisional; Region: PRK11619 399741002293 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 399741002294 N-acetyl-D-glucosamine binding site [chemical binding]; other site 399741002295 catalytic residue [active] 399741002296 Trp operon repressor; Provisional; Region: PRK01381 399741002297 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 399741002298 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 399741002299 catalytic core [active] 399741002300 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 399741002301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741002302 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 399741002303 hypothetical protein; Provisional; Region: PRK10756 399741002304 CreA protein; Region: CreA; pfam05981 399741002305 two-component response regulator; Provisional; Region: PRK11173 399741002306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741002307 active site 399741002308 phosphorylation site [posttranslational modification] 399741002309 intermolecular recognition site; other site 399741002310 dimerization interface [polypeptide binding]; other site 399741002311 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741002312 DNA binding site [nucleotide binding] 399741002313 putative RNA methyltransferase; Provisional; Region: PRK10433 399741002314 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 399741002315 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 399741002316 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 399741002317 putative catalytic residues [active] 399741002318 putative nucleotide binding site [chemical binding]; other site 399741002319 putative aspartate binding site [chemical binding]; other site 399741002320 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 399741002321 dimer interface [polypeptide binding]; other site 399741002322 putative threonine allosteric regulatory site; other site 399741002323 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 399741002324 putative threonine allosteric regulatory site; other site 399741002325 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 399741002326 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 399741002327 homoserine kinase; Provisional; Region: PRK01212 399741002328 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 399741002329 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 399741002330 threonine synthase; Validated; Region: PRK09225 399741002331 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 399741002332 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 399741002333 catalytic residue [active] 399741002334 hypothetical protein; Validated; Region: PRK02101 399741002335 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 399741002336 amino acid carrier protein; Region: agcS; TIGR00835 399741002337 transaldolase-like protein; Provisional; Region: PTZ00411 399741002338 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 399741002339 active site 399741002340 dimer interface [polypeptide binding]; other site 399741002341 catalytic residue [active] 399741002342 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 399741002343 MPT binding site; other site 399741002344 trimer interface [polypeptide binding]; other site 399741002345 metabolite-proton symporter; Region: 2A0106; TIGR00883 399741002346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741002347 putative substrate translocation pore; other site 399741002348 hypothetical protein; Provisional; Region: PRK10659 399741002349 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 399741002350 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 399741002351 nucleotide binding site [chemical binding]; other site 399741002352 chaperone protein DnaJ; Provisional; Region: PRK10767 399741002353 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 399741002354 HSP70 interaction site [polypeptide binding]; other site 399741002355 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 399741002356 substrate binding site [polypeptide binding]; other site 399741002357 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 399741002358 Zn binding sites [ion binding]; other site 399741002359 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 399741002360 dimer interface [polypeptide binding]; other site 399741002361 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 399741002362 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 399741002363 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741002364 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 399741002365 putative dimerization interface [polypeptide binding]; other site 399741002366 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 399741002367 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 399741002368 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 399741002369 active site 399741002370 Riboflavin kinase; Region: Flavokinase; smart00904 399741002371 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 399741002372 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 399741002373 active site 399741002374 HIGH motif; other site 399741002375 nucleotide binding site [chemical binding]; other site 399741002376 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 399741002377 active site 399741002378 KMSKS motif; other site 399741002379 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 399741002380 tRNA binding surface [nucleotide binding]; other site 399741002381 anticodon binding site; other site 399741002382 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 399741002383 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 399741002384 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 399741002385 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 399741002386 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 399741002387 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 399741002388 transcriptional regulator; Provisional; Region: PRK10632 399741002389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741002390 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 399741002391 putative effector binding pocket; other site 399741002392 dimerization interface [polypeptide binding]; other site 399741002393 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 399741002394 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 399741002395 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 399741002396 substrate binding pocket [chemical binding]; other site 399741002397 active site 399741002398 iron coordination sites [ion binding]; other site 399741002399 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 399741002400 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 399741002401 active site 399741002402 TDP-binding site; other site 399741002403 acceptor substrate-binding pocket; other site 399741002404 homodimer interface [polypeptide binding]; other site 399741002405 short chain dehydrogenase; Provisional; Region: PRK07063 399741002406 classical (c) SDRs; Region: SDR_c; cd05233 399741002407 NAD(P) binding site [chemical binding]; other site 399741002408 active site 399741002409 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 399741002410 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 399741002411 inhibitor site; inhibition site 399741002412 active site 399741002413 dimer interface [polypeptide binding]; other site 399741002414 catalytic residue [active] 399741002415 Dehydratase family; Region: ILVD_EDD; pfam00920 399741002416 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 399741002417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741002418 putative substrate translocation pore; other site 399741002419 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 399741002420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741002421 putative substrate translocation pore; other site 399741002422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741002423 Transcriptional regulators [Transcription]; Region: FadR; COG2186 399741002424 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741002425 DNA-binding site [nucleotide binding]; DNA binding site 399741002426 FCD domain; Region: FCD; pfam07729 399741002427 dihydrodipicolinate reductase; Provisional; Region: PRK00048 399741002428 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 399741002429 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 399741002430 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 399741002431 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 399741002432 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 399741002433 catalytic site [active] 399741002434 subunit interface [polypeptide binding]; other site 399741002435 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 399741002436 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 399741002437 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 399741002438 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 399741002439 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 399741002440 ATP-grasp domain; Region: ATP-grasp_4; cl17255 399741002441 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 399741002442 IMP binding site; other site 399741002443 dimer interface [polypeptide binding]; other site 399741002444 interdomain contacts; other site 399741002445 partial ornithine binding site; other site 399741002446 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 399741002447 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 399741002448 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 399741002449 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 399741002450 TrkA-N domain; Region: TrkA_N; pfam02254 399741002451 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 399741002452 Uncharacterized conserved protein [Function unknown]; Region: COG2966 399741002453 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 399741002454 hypothetical protein; Provisional; Region: PRK09917 399741002455 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 399741002456 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 399741002457 folate binding site [chemical binding]; other site 399741002458 NADP+ binding site [chemical binding]; other site 399741002459 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 399741002460 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 399741002461 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 399741002462 active site 399741002463 metal binding site [ion binding]; metal-binding site 399741002464 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 399741002465 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 399741002466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741002467 S-adenosylmethionine binding site [chemical binding]; other site 399741002468 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 399741002469 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 399741002470 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 399741002471 SurA N-terminal domain; Region: SurA_N; pfam09312 399741002472 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 399741002473 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 399741002474 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 399741002475 OstA-like protein; Region: OstA; pfam03968 399741002476 Organic solvent tolerance protein; Region: OstA_C; pfam04453 399741002477 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 399741002478 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 399741002479 putative metal binding site [ion binding]; other site 399741002480 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 399741002481 HSP70 interaction site [polypeptide binding]; other site 399741002482 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 399741002483 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 399741002484 active site 399741002485 ATP-dependent helicase HepA; Validated; Region: PRK04914 399741002486 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 399741002487 ATP binding site [chemical binding]; other site 399741002488 putative Mg++ binding site [ion binding]; other site 399741002489 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 399741002490 nucleotide binding region [chemical binding]; other site 399741002491 ATP-binding site [chemical binding]; other site 399741002492 DNA polymerase II; Reviewed; Region: PRK05762 399741002493 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 399741002494 active site 399741002495 catalytic site [active] 399741002496 substrate binding site [chemical binding]; other site 399741002497 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 399741002498 active site 399741002499 metal-binding site 399741002500 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 399741002501 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 399741002502 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 399741002503 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 399741002504 putative valine binding site [chemical binding]; other site 399741002505 dimer interface [polypeptide binding]; other site 399741002506 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 399741002507 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 399741002508 PYR/PP interface [polypeptide binding]; other site 399741002509 dimer interface [polypeptide binding]; other site 399741002510 TPP binding site [chemical binding]; other site 399741002511 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 399741002512 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 399741002513 TPP-binding site [chemical binding]; other site 399741002514 dimer interface [polypeptide binding]; other site 399741002515 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 399741002516 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 399741002517 Walker A/P-loop; other site 399741002518 ATP binding site [chemical binding]; other site 399741002519 Q-loop/lid; other site 399741002520 ABC transporter signature motif; other site 399741002521 Walker B; other site 399741002522 D-loop; other site 399741002523 H-loop/switch region; other site 399741002524 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 399741002525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741002526 dimer interface [polypeptide binding]; other site 399741002527 conserved gate region; other site 399741002528 putative PBP binding loops; other site 399741002529 ABC-ATPase subunit interface; other site 399741002530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741002531 dimer interface [polypeptide binding]; other site 399741002532 conserved gate region; other site 399741002533 putative PBP binding loops; other site 399741002534 ABC-ATPase subunit interface; other site 399741002535 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 399741002536 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 399741002537 transcriptional regulator SgrR; Provisional; Region: PRK13626 399741002538 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 399741002539 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 399741002540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741002541 sugar efflux transporter; Region: 2A0120; TIGR00899 399741002542 putative substrate translocation pore; other site 399741002543 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 399741002544 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 399741002545 transmembrane helices; other site 399741002546 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 399741002547 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 399741002548 substrate binding site [chemical binding]; other site 399741002549 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 399741002550 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 399741002551 substrate binding site [chemical binding]; other site 399741002552 ligand binding site [chemical binding]; other site 399741002553 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 399741002554 tartrate dehydrogenase; Region: TTC; TIGR02089 399741002555 2-isopropylmalate synthase; Validated; Region: PRK00915 399741002556 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 399741002557 active site 399741002558 catalytic residues [active] 399741002559 metal binding site [ion binding]; metal-binding site 399741002560 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 399741002561 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 399741002562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741002563 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 399741002564 putative substrate binding pocket [chemical binding]; other site 399741002565 putative dimerization interface [polypeptide binding]; other site 399741002566 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 399741002567 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 399741002568 acyl-activating enzyme (AAE) consensus motif; other site 399741002569 putative AMP binding site [chemical binding]; other site 399741002570 putative active site [active] 399741002571 putative CoA binding site [chemical binding]; other site 399741002572 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 399741002573 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 399741002574 PYR/PP interface [polypeptide binding]; other site 399741002575 dimer interface [polypeptide binding]; other site 399741002576 TPP binding site [chemical binding]; other site 399741002577 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 399741002578 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 399741002579 TPP-binding site [chemical binding]; other site 399741002580 dimer interface [polypeptide binding]; other site 399741002581 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 399741002582 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 399741002583 putative valine binding site [chemical binding]; other site 399741002584 dimer interface [polypeptide binding]; other site 399741002585 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 399741002586 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 399741002587 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741002588 DNA binding site [nucleotide binding] 399741002589 domain linker motif; other site 399741002590 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 399741002591 dimerization interface [polypeptide binding]; other site 399741002592 ligand binding site [chemical binding]; other site 399741002593 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 399741002594 cell division protein MraZ; Reviewed; Region: PRK00326 399741002595 MraZ protein; Region: MraZ; pfam02381 399741002596 MraZ protein; Region: MraZ; pfam02381 399741002597 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 399741002598 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 399741002599 cell division protein FtsL; Provisional; Region: PRK10772 399741002600 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 399741002601 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 399741002602 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 399741002603 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 399741002604 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 399741002605 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 399741002606 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 399741002607 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 399741002608 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 399741002609 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 399741002610 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 399741002611 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 399741002612 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 399741002613 Mg++ binding site [ion binding]; other site 399741002614 putative catalytic motif [active] 399741002615 putative substrate binding site [chemical binding]; other site 399741002616 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 399741002617 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 399741002618 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 399741002619 cell division protein FtsW; Provisional; Region: PRK10774 399741002620 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 399741002621 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 399741002622 active site 399741002623 homodimer interface [polypeptide binding]; other site 399741002624 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 399741002625 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 399741002626 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 399741002627 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 399741002628 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 399741002629 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 399741002630 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 399741002631 cell division protein FtsQ; Provisional; Region: PRK10775 399741002632 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 399741002633 Cell division protein FtsQ; Region: FtsQ; pfam03799 399741002634 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 399741002635 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 399741002636 Cell division protein FtsA; Region: FtsA; pfam14450 399741002637 cell division protein FtsZ; Validated; Region: PRK09330 399741002638 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 399741002639 nucleotide binding site [chemical binding]; other site 399741002640 SulA interaction site; other site 399741002641 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 399741002642 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 399741002643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701 399741002644 SecA regulator SecM; Provisional; Region: PRK02943 399741002645 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 399741002646 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 399741002647 SEC-C motif; Region: SEC-C; pfam02810 399741002648 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 399741002649 active site 399741002650 8-oxo-dGMP binding site [chemical binding]; other site 399741002651 nudix motif; other site 399741002652 metal binding site [ion binding]; metal-binding site 399741002653 DNA gyrase inhibitor; Reviewed; Region: PRK00418 399741002654 hypothetical protein; Provisional; Region: PRK05287 399741002655 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 399741002656 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 399741002657 CoA-binding site [chemical binding]; other site 399741002658 ATP-binding [chemical binding]; other site 399741002659 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 399741002660 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 399741002661 active site 399741002662 type IV pilin biogenesis protein; Provisional; Region: PRK10573 399741002663 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 399741002664 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 399741002665 hypothetical protein; Provisional; Region: PRK10436 399741002666 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 399741002667 Walker A motif; other site 399741002668 ATP binding site [chemical binding]; other site 399741002669 Walker B motif; other site 399741002670 putative major pilin subunit; Provisional; Region: PRK10574 399741002671 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 399741002672 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 399741002673 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 399741002674 dimerization interface [polypeptide binding]; other site 399741002675 active site 399741002676 regulatory protein AmpE; Provisional; Region: PRK10987 399741002677 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 399741002678 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 399741002679 inhibitor-cofactor binding pocket; inhibition site 399741002680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741002681 catalytic residue [active] 399741002682 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 399741002683 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 399741002684 Cl- selectivity filter; other site 399741002685 Cl- binding residues [ion binding]; other site 399741002686 pore gating glutamate residue; other site 399741002687 dimer interface [polypeptide binding]; other site 399741002688 H+/Cl- coupling transport residue; other site 399741002689 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 399741002690 hypothetical protein; Provisional; Region: PRK10578 399741002691 UPF0126 domain; Region: UPF0126; pfam03458 399741002692 UPF0126 domain; Region: UPF0126; pfam03458 399741002693 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 399741002694 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 399741002695 cobalamin binding residues [chemical binding]; other site 399741002696 putative BtuC binding residues; other site 399741002697 dimer interface [polypeptide binding]; other site 399741002698 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 399741002699 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 399741002700 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 399741002701 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 399741002702 Zn2+ binding site [ion binding]; other site 399741002703 Mg2+ binding site [ion binding]; other site 399741002704 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 399741002705 serine endoprotease; Provisional; Region: PRK10942 399741002706 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 399741002707 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 399741002708 protein binding site [polypeptide binding]; other site 399741002709 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 399741002710 protein binding site [polypeptide binding]; other site 399741002711 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 399741002712 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 399741002713 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 399741002714 dimerization interface [polypeptide binding]; other site 399741002715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741002716 dimer interface [polypeptide binding]; other site 399741002717 phosphorylation site [posttranslational modification] 399741002718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741002719 ATP binding site [chemical binding]; other site 399741002720 Mg2+ binding site [ion binding]; other site 399741002721 G-X-G motif; other site 399741002722 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 399741002723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741002724 active site 399741002725 phosphorylation site [posttranslational modification] 399741002726 intermolecular recognition site; other site 399741002727 dimerization interface [polypeptide binding]; other site 399741002728 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 399741002729 putative binding surface; other site 399741002730 active site 399741002731 DNA methylase; Region: N6_N4_Mtase; cl17433 399741002732 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 399741002733 HD domain; Region: HD_4; pfam13328 399741002734 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 399741002735 synthetase active site [active] 399741002736 NTP binding site [chemical binding]; other site 399741002737 metal binding site [ion binding]; metal-binding site 399741002738 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 399741002739 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 399741002740 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 399741002741 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 399741002742 homodimer interface [polypeptide binding]; other site 399741002743 metal binding site [ion binding]; metal-binding site 399741002744 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 399741002745 homodimer interface [polypeptide binding]; other site 399741002746 active site 399741002747 putative chemical substrate binding site [chemical binding]; other site 399741002748 metal binding site [ion binding]; metal-binding site 399741002749 CTP synthetase; Validated; Region: pyrG; PRK05380 399741002750 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 399741002751 Catalytic site [active] 399741002752 active site 399741002753 UTP binding site [chemical binding]; other site 399741002754 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 399741002755 active site 399741002756 putative oxyanion hole; other site 399741002757 catalytic triad [active] 399741002758 enolase; Provisional; Region: eno; PRK00077 399741002759 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 399741002760 dimer interface [polypeptide binding]; other site 399741002761 metal binding site [ion binding]; metal-binding site 399741002762 substrate binding pocket [chemical binding]; other site 399741002763 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 399741002764 methionine gamma-lyase; Provisional; Region: PRK07503 399741002765 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 399741002766 homodimer interface [polypeptide binding]; other site 399741002767 substrate-cofactor binding pocket; other site 399741002768 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741002769 catalytic residue [active] 399741002770 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 399741002771 active sites [active] 399741002772 tetramer interface [polypeptide binding]; other site 399741002773 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 399741002774 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 399741002775 Walker A/P-loop; other site 399741002776 ATP binding site [chemical binding]; other site 399741002777 Q-loop/lid; other site 399741002778 ABC transporter signature motif; other site 399741002779 Walker B; other site 399741002780 D-loop; other site 399741002781 H-loop/switch region; other site 399741002782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741002783 dimer interface [polypeptide binding]; other site 399741002784 conserved gate region; other site 399741002785 putative PBP binding loops; other site 399741002786 ABC-ATPase subunit interface; other site 399741002787 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 399741002788 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 399741002789 putative proline-specific permease; Provisional; Region: proY; PRK10580 399741002790 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 399741002791 active sites [active] 399741002792 tetramer interface [polypeptide binding]; other site 399741002793 urocanate hydratase; Provisional; Region: PRK05414 399741002794 benzoate transport; Region: 2A0115; TIGR00895 399741002795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741002796 putative substrate translocation pore; other site 399741002797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741002798 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 399741002799 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 399741002800 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 399741002801 active site 399741002802 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 399741002803 Flavodoxin; Region: Flavodoxin_1; pfam00258 399741002804 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 399741002805 FAD binding pocket [chemical binding]; other site 399741002806 FAD binding motif [chemical binding]; other site 399741002807 catalytic residues [active] 399741002808 NAD binding pocket [chemical binding]; other site 399741002809 phosphate binding motif [ion binding]; other site 399741002810 beta-alpha-beta structure motif; other site 399741002811 sulfite reductase subunit beta; Provisional; Region: PRK13504 399741002812 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 399741002813 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 399741002814 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 399741002815 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 399741002816 Active Sites [active] 399741002817 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 399741002818 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 399741002819 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 399741002820 metal binding site [ion binding]; metal-binding site 399741002821 siroheme synthase; Provisional; Region: cysG; PRK10637 399741002822 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 399741002823 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 399741002824 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 399741002825 active site 399741002826 SAM binding site [chemical binding]; other site 399741002827 homodimer interface [polypeptide binding]; other site 399741002828 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 399741002829 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 399741002830 Active Sites [active] 399741002831 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 399741002832 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 399741002833 CysD dimerization site [polypeptide binding]; other site 399741002834 G1 box; other site 399741002835 putative GEF interaction site [polypeptide binding]; other site 399741002836 GTP/Mg2+ binding site [chemical binding]; other site 399741002837 Switch I region; other site 399741002838 G2 box; other site 399741002839 G3 box; other site 399741002840 Switch II region; other site 399741002841 G4 box; other site 399741002842 G5 box; other site 399741002843 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 399741002844 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 399741002845 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 399741002846 ligand-binding site [chemical binding]; other site 399741002847 hypothetical protein; Provisional; Region: PRK10726 399741002848 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 399741002849 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 399741002850 Walker A/P-loop; other site 399741002851 ATP binding site [chemical binding]; other site 399741002852 Q-loop/lid; other site 399741002853 ABC transporter signature motif; other site 399741002854 Walker B; other site 399741002855 D-loop; other site 399741002856 H-loop/switch region; other site 399741002857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741002858 dimer interface [polypeptide binding]; other site 399741002859 conserved gate region; other site 399741002860 putative PBP binding loops; other site 399741002861 ABC-ATPase subunit interface; other site 399741002862 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741002863 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 399741002864 substrate binding pocket [chemical binding]; other site 399741002865 membrane-bound complex binding site; other site 399741002866 hinge residues; other site 399741002867 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 399741002868 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 399741002869 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 399741002870 substrate binding site; other site 399741002871 dimer interface; other site 399741002872 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 399741002873 homotrimer interaction site [polypeptide binding]; other site 399741002874 zinc binding site [ion binding]; other site 399741002875 CDP-binding sites; other site 399741002876 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 399741002877 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 399741002878 Permutation of conserved domain; other site 399741002879 active site 399741002880 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 399741002881 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 399741002882 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 399741002883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741002884 S-adenosylmethionine binding site [chemical binding]; other site 399741002885 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 399741002886 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 399741002887 Peptidase family M23; Region: Peptidase_M23; pfam01551 399741002888 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 399741002889 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 399741002890 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 399741002891 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 399741002892 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 399741002893 DNA binding residues [nucleotide binding] 399741002894 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 399741002895 MutS domain I; Region: MutS_I; pfam01624 399741002896 MutS domain II; Region: MutS_II; pfam05188 399741002897 MutS domain III; Region: MutS_III; pfam05192 399741002898 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 399741002899 Walker A/P-loop; other site 399741002900 ATP binding site [chemical binding]; other site 399741002901 Q-loop/lid; other site 399741002902 ABC transporter signature motif; other site 399741002903 Walker B; other site 399741002904 D-loop; other site 399741002905 H-loop/switch region; other site 399741002906 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 399741002907 active site 399741002908 P-loop; other site 399741002909 phosphorylation site [posttranslational modification] 399741002910 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 399741002911 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 399741002912 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 399741002913 beta-galactosidase; Region: BGL; TIGR03356 399741002914 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 399741002915 Cupin domain; Region: Cupin_2; pfam07883 399741002916 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741002917 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 399741002918 putative active site [active] 399741002919 YdjC motif; other site 399741002920 Mg binding site [ion binding]; other site 399741002921 putative homodimer interface [polypeptide binding]; other site 399741002922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741002923 putative substrate translocation pore; other site 399741002924 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741002925 hypothetical protein; Validated; Region: PRK03661 399741002926 recombinase A; Provisional; Region: recA; PRK09354 399741002927 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 399741002928 hexamer interface [polypeptide binding]; other site 399741002929 Walker A motif; other site 399741002930 ATP binding site [chemical binding]; other site 399741002931 Walker B motif; other site 399741002932 recombination regulator RecX; Reviewed; Region: recX; PRK00117 399741002933 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 399741002934 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 399741002935 motif 1; other site 399741002936 active site 399741002937 motif 2; other site 399741002938 motif 3; other site 399741002939 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 399741002940 DHHA1 domain; Region: DHHA1; pfam02272 399741002941 carbon storage regulator; Provisional; Region: PRK01712 399741002942 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 399741002943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741002944 motif II; other site 399741002945 Predicted membrane protein [Function unknown]; Region: COG1238 399741002946 glutamate--cysteine ligase; Provisional; Region: PRK02107 399741002947 S-ribosylhomocysteinase; Provisional; Region: PRK02260 399741002948 hypothetical protein; Provisional; Region: PRK11573 399741002949 Domain of unknown function DUF21; Region: DUF21; pfam01595 399741002950 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 399741002951 Transporter associated domain; Region: CorC_HlyC; smart01091 399741002952 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 399741002953 signal recognition particle protein; Provisional; Region: PRK10867 399741002954 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 399741002955 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 399741002956 P loop; other site 399741002957 GTP binding site [chemical binding]; other site 399741002958 Signal peptide binding domain; Region: SRP_SPB; pfam02978 399741002959 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 399741002960 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 399741002961 RimM N-terminal domain; Region: RimM; pfam01782 399741002962 PRC-barrel domain; Region: PRC; pfam05239 399741002963 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 399741002964 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 399741002965 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 399741002966 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 399741002967 tail protein; Provisional; Region: D; PHA02561 399741002968 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 399741002969 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 399741002970 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 399741002971 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 399741002972 major tail tube protein; Provisional; Region: FII; PHA02600 399741002973 major tail sheath protein; Provisional; Region: FI; PHA02560 399741002974 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 399741002975 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 399741002976 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 399741002977 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 399741002978 baseplate assembly protein; Provisional; Region: J; PHA02568 399741002979 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 399741002980 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 399741002981 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 399741002982 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 399741002983 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 399741002984 catalytic residues [active] 399741002985 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 399741002986 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 399741002987 DksA-like zinc finger domain containing protein; Region: PHA00080 399741002988 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 399741002989 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 399741002990 Protein of unknown function, DUF481; Region: DUF481; cl01213 399741002991 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 399741002992 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 399741002993 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 399741002994 Chorismate mutase type II; Region: CM_2; cl00693 399741002995 prephenate dehydrogenase; Validated; Region: PRK08507 399741002996 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 399741002997 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 399741002998 Prephenate dehydratase; Region: PDT; pfam00800 399741002999 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 399741003000 putative L-Phe binding site [chemical binding]; other site 399741003001 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 399741003002 30S subunit binding site; other site 399741003003 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 399741003004 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 399741003005 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 399741003006 RNA binding surface [nucleotide binding]; other site 399741003007 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 399741003008 active site 399741003009 hypothetical protein; Provisional; Region: PRK10723 399741003010 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 399741003011 protein disaggregation chaperone; Provisional; Region: PRK10865 399741003012 Clp amino terminal domain; Region: Clp_N; pfam02861 399741003013 Clp amino terminal domain; Region: Clp_N; pfam02861 399741003014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741003015 Walker A motif; other site 399741003016 ATP binding site [chemical binding]; other site 399741003017 Walker B motif; other site 399741003018 arginine finger; other site 399741003019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741003020 Walker A motif; other site 399741003021 ATP binding site [chemical binding]; other site 399741003022 Walker B motif; other site 399741003023 arginine finger; other site 399741003024 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 399741003025 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 399741003026 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 399741003027 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 399741003028 putative acyl-acceptor binding pocket; other site 399741003029 Phosphopantetheine attachment site; Region: PP-binding; cl09936 399741003030 acyl carrier protein; Provisional; Region: PRK05350 399741003031 Predicted membrane protein [Function unknown]; Region: COG4648 399741003032 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 399741003033 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 399741003034 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 399741003035 acyl-activating enzyme (AAE) consensus motif; other site 399741003036 acyl-activating enzyme (AAE) consensus motif; other site 399741003037 AMP binding site [chemical binding]; other site 399741003038 active site 399741003039 CoA binding site [chemical binding]; other site 399741003040 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 399741003041 active site 2 [active] 399741003042 active site 1 [active] 399741003043 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 399741003044 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 399741003045 Ligand binding site; other site 399741003046 Putative Catalytic site; other site 399741003047 DXD motif; other site 399741003048 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 399741003049 putative acyl-acceptor binding pocket; other site 399741003050 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 399741003051 active site 399741003052 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 399741003053 Predicted exporter [General function prediction only]; Region: COG4258 399741003054 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 399741003055 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 399741003056 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 399741003057 dimer interface [polypeptide binding]; other site 399741003058 active site 399741003059 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 399741003060 putative active site 1 [active] 399741003061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 399741003062 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 399741003063 NAD(P) binding site [chemical binding]; other site 399741003064 active site 399741003065 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 399741003066 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 399741003067 dimer interface [polypeptide binding]; other site 399741003068 active site 399741003069 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 399741003070 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 399741003071 active site 399741003072 catalytic tetrad [active] 399741003073 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741003074 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741003075 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741003076 dimerization interface [polypeptide binding]; other site 399741003077 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 399741003078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741003079 putative substrate translocation pore; other site 399741003080 hypothetical protein; Provisional; Region: PRK05421 399741003081 putative catalytic site [active] 399741003082 putative phosphate binding site [ion binding]; other site 399741003083 putative metal binding site [ion binding]; other site 399741003084 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 399741003085 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 399741003086 N-acetyl-D-glucosamine binding site [chemical binding]; other site 399741003087 catalytic residue [active] 399741003088 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 399741003089 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 399741003090 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 399741003091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741003092 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 399741003093 RNA/DNA hybrid binding site [nucleotide binding]; other site 399741003094 active site 399741003095 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 399741003096 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 399741003097 active site 399741003098 catalytic site [active] 399741003099 substrate binding site [chemical binding]; other site 399741003100 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 399741003101 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 399741003102 Na binding site [ion binding]; other site 399741003103 putative substrate binding site [chemical binding]; other site 399741003104 Transcriptional regulators [Transcription]; Region: FadR; COG2186 399741003105 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741003106 DNA-binding site [nucleotide binding]; DNA binding site 399741003107 FCD domain; Region: FCD; pfam07729 399741003108 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 399741003109 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 399741003110 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 399741003111 active site 399741003112 catalytic site [active] 399741003113 tetramer interface [polypeptide binding]; other site 399741003114 Helix-turn-helix domain; Region: HTH_37; pfam13744 399741003115 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 399741003116 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 399741003117 N-terminal plug; other site 399741003118 ligand-binding site [chemical binding]; other site 399741003119 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 399741003120 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 399741003121 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 399741003122 IucA / IucC family; Region: IucA_IucC; pfam04183 399741003123 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 399741003124 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 399741003125 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 399741003126 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 399741003127 IucA / IucC family; Region: IucA_IucC; pfam04183 399741003128 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 399741003129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741003130 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741003131 putative substrate translocation pore; other site 399741003132 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 399741003133 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 399741003134 FAD binding pocket [chemical binding]; other site 399741003135 FAD binding motif [chemical binding]; other site 399741003136 phosphate binding motif [ion binding]; other site 399741003137 NAD binding pocket [chemical binding]; other site 399741003138 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 399741003139 Predicted transcriptional regulator [Transcription]; Region: COG3905 399741003140 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 399741003141 SnoaL-like domain; Region: SnoaL_3; pfam13474 399741003142 amidase; Provisional; Region: PRK09201 399741003143 Amidase; Region: Amidase; pfam01425 399741003144 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 399741003145 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 399741003146 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 399741003147 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 399741003148 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 399741003149 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 399741003150 putative active site [active] 399741003151 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 399741003152 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741003153 substrate binding pocket [chemical binding]; other site 399741003154 membrane-bound complex binding site; other site 399741003155 hinge residues; other site 399741003156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741003157 dimer interface [polypeptide binding]; other site 399741003158 conserved gate region; other site 399741003159 putative PBP binding loops; other site 399741003160 ABC-ATPase subunit interface; other site 399741003161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 399741003162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741003163 ABC-ATPase subunit interface; other site 399741003164 putative PBP binding loops; other site 399741003165 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 399741003166 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 399741003167 Walker A/P-loop; other site 399741003168 ATP binding site [chemical binding]; other site 399741003169 Q-loop/lid; other site 399741003170 ABC transporter signature motif; other site 399741003171 Walker B; other site 399741003172 D-loop; other site 399741003173 H-loop/switch region; other site 399741003174 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 399741003175 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 399741003176 catalytic residue [active] 399741003177 allantoate amidohydrolase; Reviewed; Region: PRK09290 399741003178 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 399741003179 active site 399741003180 metal binding site [ion binding]; metal-binding site 399741003181 dimer interface [polypeptide binding]; other site 399741003182 putative OHCU decarboxylase; Provisional; Region: PRK13798 399741003183 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 399741003184 active site 399741003185 homotetramer interface [polypeptide binding]; other site 399741003186 C-N hydrolase family amidase; Provisional; Region: PRK10438 399741003187 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 399741003188 putative active site [active] 399741003189 catalytic triad [active] 399741003190 dimer interface [polypeptide binding]; other site 399741003191 multimer interface [polypeptide binding]; other site 399741003192 methionine aminotransferase; Validated; Region: PRK09082 399741003193 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741003194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741003195 homodimer interface [polypeptide binding]; other site 399741003196 catalytic residue [active] 399741003197 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 399741003198 intersubunit interface [polypeptide binding]; other site 399741003199 active site 399741003200 Zn2+ binding site [ion binding]; other site 399741003201 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 399741003202 Cupin domain; Region: Cupin_2; cl17218 399741003203 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 399741003204 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 399741003205 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 399741003206 Hok/gef family; Region: HOK_GEF; pfam01848 399741003207 Hok/gef family; Region: HOK_GEF; pfam01848 399741003208 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 399741003209 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 399741003210 active site 399741003211 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 399741003212 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 399741003213 dimer interface [polypeptide binding]; other site 399741003214 active site 399741003215 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 399741003216 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 399741003217 putative active site [active] 399741003218 putative dimer interface [polypeptide binding]; other site 399741003219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 399741003220 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 399741003221 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 399741003222 E3 interaction surface; other site 399741003223 lipoyl attachment site [posttranslational modification]; other site 399741003224 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 399741003225 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 399741003226 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 399741003227 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 399741003228 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 399741003229 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 399741003230 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 399741003231 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 399741003232 catalytic loop [active] 399741003233 iron binding site [ion binding]; other site 399741003234 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 399741003235 FAD binding pocket [chemical binding]; other site 399741003236 FAD binding motif [chemical binding]; other site 399741003237 phosphate binding motif [ion binding]; other site 399741003238 beta-alpha-beta structure motif; other site 399741003239 NAD binding pocket [chemical binding]; other site 399741003240 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 399741003241 ApbE family; Region: ApbE; pfam02424 399741003242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 399741003243 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 399741003244 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 399741003245 active site 399741003246 catalytic site [active] 399741003247 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 399741003248 active site 399741003249 DNA polymerase IV; Validated; Region: PRK02406 399741003250 DNA binding site [nucleotide binding] 399741003251 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 399741003252 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 399741003253 metal binding site [ion binding]; metal-binding site 399741003254 dimer interface [polypeptide binding]; other site 399741003255 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 399741003256 active site 399741003257 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 399741003258 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 399741003259 gamma-glutamyl kinase; Provisional; Region: PRK05429 399741003260 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 399741003261 nucleotide binding site [chemical binding]; other site 399741003262 homotetrameric interface [polypeptide binding]; other site 399741003263 putative phosphate binding site [ion binding]; other site 399741003264 putative allosteric binding site; other site 399741003265 PUA domain; Region: PUA; pfam01472 399741003266 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 399741003267 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 399741003268 putative catalytic cysteine [active] 399741003269 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 399741003270 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741003271 Coenzyme A binding pocket [chemical binding]; other site 399741003272 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 399741003273 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 399741003274 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 399741003275 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 399741003276 peptide binding site [polypeptide binding]; other site 399741003277 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 399741003278 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 399741003279 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 399741003280 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 399741003281 Condensation domain; Region: Condensation; pfam00668 399741003282 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 399741003283 Uncharacterized conserved protein [Function unknown]; Region: COG3391 399741003284 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 399741003285 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 399741003286 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 399741003287 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 399741003288 catalytic residues [active] 399741003289 hinge region; other site 399741003290 alpha helical domain; other site 399741003291 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 399741003292 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741003293 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 399741003294 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 399741003295 NAD(P) binding site [chemical binding]; other site 399741003296 catalytic residues [active] 399741003297 leucine export protein LeuE; Provisional; Region: PRK10958 399741003298 tellurite resistance protein TehB; Provisional; Region: PRK12335 399741003299 Domain of unknown function (DUF1971); Region: DUF1971; pfam09313 399741003300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741003301 S-adenosylmethionine binding site [chemical binding]; other site 399741003302 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 399741003303 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 399741003304 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 399741003305 C-terminal domain interface [polypeptide binding]; other site 399741003306 GSH binding site (G-site) [chemical binding]; other site 399741003307 dimer interface [polypeptide binding]; other site 399741003308 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 399741003309 dimer interface [polypeptide binding]; other site 399741003310 N-terminal domain interface [polypeptide binding]; other site 399741003311 putative substrate binding pocket (H-site) [chemical binding]; other site 399741003312 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 399741003313 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741003314 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741003315 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 399741003316 dimerization interface [polypeptide binding]; other site 399741003317 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 399741003318 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 399741003319 dimer interface [polypeptide binding]; other site 399741003320 PYR/PP interface [polypeptide binding]; other site 399741003321 TPP binding site [chemical binding]; other site 399741003322 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 399741003323 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 399741003324 TPP-binding site [chemical binding]; other site 399741003325 dimer interface [polypeptide binding]; other site 399741003326 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 399741003327 hypothetical protein; Provisional; Region: PRK11667 399741003328 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 399741003329 Domain of unknown function (DUF333); Region: DUF333; pfam03891 399741003330 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 399741003331 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 399741003332 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 399741003333 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 399741003334 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 399741003335 active site 399741003336 metal binding site [ion binding]; metal-binding site 399741003337 LysR family transcriptional regulator; Provisional; Region: PRK14997 399741003338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741003339 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 399741003340 putative effector binding pocket; other site 399741003341 putative dimerization interface [polypeptide binding]; other site 399741003342 Pirin-related protein [General function prediction only]; Region: COG1741 399741003343 Pirin; Region: Pirin; pfam02678 399741003344 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 399741003345 Isochorismatase family; Region: Isochorismatase; pfam00857 399741003346 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 399741003347 catalytic triad [active] 399741003348 dimer interface [polypeptide binding]; other site 399741003349 conserved cis-peptide bond; other site 399741003350 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 399741003351 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 399741003352 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 399741003353 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 399741003354 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 399741003355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741003356 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 399741003357 salt bridge; other site 399741003358 non-specific DNA binding site [nucleotide binding]; other site 399741003359 sequence-specific DNA binding site [nucleotide binding]; other site 399741003360 Methyltransferase domain; Region: Methyltransf_31; pfam13847 399741003361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741003362 S-adenosylmethionine binding site [chemical binding]; other site 399741003363 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 399741003364 amphipathic channel; other site 399741003365 Asn-Pro-Ala signature motifs; other site 399741003366 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 399741003367 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 399741003368 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 399741003369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 399741003370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741003371 Coenzyme A binding pocket [chemical binding]; other site 399741003372 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 399741003373 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 399741003374 putative ligand binding residues [chemical binding]; other site 399741003375 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 399741003376 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 399741003377 N-terminal plug; other site 399741003378 ligand-binding site [chemical binding]; other site 399741003379 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 399741003380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741003381 Coenzyme A binding pocket [chemical binding]; other site 399741003382 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 399741003383 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 399741003384 ADP binding site [chemical binding]; other site 399741003385 magnesium binding site [ion binding]; other site 399741003386 putative shikimate binding site; other site 399741003387 Helix-turn-helix domain; Region: HTH_18; pfam12833 399741003388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741003389 SnoaL-like domain; Region: SnoaL_2; pfam12680 399741003390 hypothetical protein; Provisional; Region: PRK10380 399741003391 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 399741003392 Transcriptional regulator [Transcription]; Region: IclR; COG1414 399741003393 Bacterial transcriptional regulator; Region: IclR; pfam01614 399741003394 OPT oligopeptide transporter protein; Region: OPT; cl14607 399741003395 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 399741003396 hypothetical protein; Provisional; Region: PRK10481 399741003397 hypothetical protein; Provisional; Region: PRK10579 399741003398 recombination associated protein; Reviewed; Region: rdgC; PRK00321 399741003399 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 399741003400 dimerization interface [polypeptide binding]; other site 399741003401 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 399741003402 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 399741003403 putative active site [active] 399741003404 heme pocket [chemical binding]; other site 399741003405 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741003406 dimer interface [polypeptide binding]; other site 399741003407 phosphorylation site [posttranslational modification] 399741003408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741003409 ATP binding site [chemical binding]; other site 399741003410 Mg2+ binding site [ion binding]; other site 399741003411 G-X-G motif; other site 399741003412 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 399741003413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741003414 active site 399741003415 phosphorylation site [posttranslational modification] 399741003416 intermolecular recognition site; other site 399741003417 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 399741003418 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 399741003419 Walker A/P-loop; other site 399741003420 ATP binding site [chemical binding]; other site 399741003421 Q-loop/lid; other site 399741003422 ABC transporter signature motif; other site 399741003423 Walker B; other site 399741003424 D-loop; other site 399741003425 H-loop/switch region; other site 399741003426 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 399741003427 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 399741003428 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 399741003429 TM-ABC transporter signature motif; other site 399741003430 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 399741003431 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 399741003432 putative ligand binding site [chemical binding]; other site 399741003433 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 399741003434 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 399741003435 intersubunit interface [polypeptide binding]; other site 399741003436 active site 399741003437 zinc binding site [ion binding]; other site 399741003438 Na+ binding site [ion binding]; other site 399741003439 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 399741003440 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 399741003441 substrate binding site [chemical binding]; other site 399741003442 ATP binding site [chemical binding]; other site 399741003443 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 399741003444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741003445 active site 399741003446 phosphorylation site [posttranslational modification] 399741003447 intermolecular recognition site; other site 399741003448 dimerization interface [polypeptide binding]; other site 399741003449 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741003450 DNA binding site [nucleotide binding] 399741003451 fructokinase; Reviewed; Region: PRK09557 399741003452 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 399741003453 nucleotide binding site [chemical binding]; other site 399741003454 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 399741003455 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 399741003456 putative active site [active] 399741003457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741003458 AAA domain; Region: AAA_23; pfam13476 399741003459 Walker A/P-loop; other site 399741003460 ATP binding site [chemical binding]; other site 399741003461 Q-loop/lid; other site 399741003462 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 399741003463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741003464 ABC transporter signature motif; other site 399741003465 Walker B; other site 399741003466 D-loop; other site 399741003467 H-loop/switch region; other site 399741003468 exonuclease subunit SbcD; Provisional; Region: PRK10966 399741003469 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 399741003470 active site 399741003471 metal binding site [ion binding]; metal-binding site 399741003472 DNA binding site [nucleotide binding] 399741003473 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 399741003474 transcriptional regulator PhoB; Provisional; Region: PRK10161 399741003475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741003476 active site 399741003477 phosphorylation site [posttranslational modification] 399741003478 intermolecular recognition site; other site 399741003479 dimerization interface [polypeptide binding]; other site 399741003480 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741003481 DNA binding site [nucleotide binding] 399741003482 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 399741003483 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 399741003484 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 399741003485 putative active site [active] 399741003486 heme pocket [chemical binding]; other site 399741003487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741003488 dimer interface [polypeptide binding]; other site 399741003489 phosphorylation site [posttranslational modification] 399741003490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741003491 ATP binding site [chemical binding]; other site 399741003492 Mg2+ binding site [ion binding]; other site 399741003493 G-X-G motif; other site 399741003494 PBP superfamily domain; Region: PBP_like_2; cl17296 399741003495 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 399741003496 substrate binding site [chemical binding]; other site 399741003497 THF binding site; other site 399741003498 zinc-binding site [ion binding]; other site 399741003499 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 399741003500 putative proline-specific permease; Provisional; Region: proY; PRK10580 399741003501 Spore germination protein; Region: Spore_permease; cl17796 399741003502 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 399741003503 Mechanosensitive ion channel; Region: MS_channel; pfam00924 399741003504 maltodextrin glucosidase; Provisional; Region: PRK10785 399741003505 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 399741003506 homodimer interface [polypeptide binding]; other site 399741003507 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 399741003508 active site 399741003509 homodimer interface [polypeptide binding]; other site 399741003510 catalytic site [active] 399741003511 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 399741003512 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741003513 DNA binding residues [nucleotide binding] 399741003514 dimerization interface [polypeptide binding]; other site 399741003515 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 399741003516 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741003517 DNA binding residues [nucleotide binding] 399741003518 dimerization interface [polypeptide binding]; other site 399741003519 Fimbrial protein; Region: Fimbrial; cl01416 399741003520 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 399741003521 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 399741003522 PapC N-terminal domain; Region: PapC_N; pfam13954 399741003523 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 399741003524 PapC C-terminal domain; Region: PapC_C; pfam13953 399741003525 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 399741003526 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 399741003527 Fimbrial protein; Region: Fimbrial; cl01416 399741003528 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 399741003529 active site 399741003530 DNA binding site [nucleotide binding] 399741003531 Int/Topo IB signature motif; other site 399741003532 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 399741003533 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 399741003534 peroxidase; Provisional; Region: PRK15000 399741003535 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 399741003536 dimer interface [polypeptide binding]; other site 399741003537 decamer (pentamer of dimers) interface [polypeptide binding]; other site 399741003538 catalytic triad [active] 399741003539 peroxidatic and resolving cysteines [active] 399741003540 Protein of unknown function, DUF479; Region: DUF479; cl01203 399741003541 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 399741003542 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 399741003543 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 399741003544 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 399741003545 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 399741003546 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 399741003547 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 399741003548 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 399741003549 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 399741003550 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 399741003551 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 399741003552 Protein export membrane protein; Region: SecD_SecF; pfam02355 399741003553 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 399741003554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741003555 active site 399741003556 phosphorylation site [posttranslational modification] 399741003557 intermolecular recognition site; other site 399741003558 dimerization interface [polypeptide binding]; other site 399741003559 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741003560 DNA binding residues [nucleotide binding] 399741003561 dimerization interface [polypeptide binding]; other site 399741003562 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 399741003563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741003564 dimer interface [polypeptide binding]; other site 399741003565 phosphorylation site [posttranslational modification] 399741003566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741003567 ATP binding site [chemical binding]; other site 399741003568 Mg2+ binding site [ion binding]; other site 399741003569 G-X-G motif; other site 399741003570 tetrathionate reductase subunit B; Provisional; Region: PRK14993 399741003571 4Fe-4S binding domain; Region: Fer4; pfam00037 399741003572 tetrathionate reductase subunit C; Provisional; Region: PRK14992 399741003573 tetrathionate reductase subunit A; Provisional; Region: PRK14991 399741003574 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 399741003575 molybdopterin cofactor binding site; other site 399741003576 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 399741003577 putative molybdopterin cofactor binding site [chemical binding]; other site 399741003578 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 399741003579 putative molybdopterin cofactor binding site; other site 399741003580 hypothetical protein; Provisional; Region: PRK11530 399741003581 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 399741003582 ATP cone domain; Region: ATP-cone; pfam03477 399741003583 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 399741003584 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 399741003585 catalytic motif [active] 399741003586 Zn binding site [ion binding]; other site 399741003587 RibD C-terminal domain; Region: RibD_C; cl17279 399741003588 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 399741003589 homopentamer interface [polypeptide binding]; other site 399741003590 active site 399741003591 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 399741003592 putative RNA binding site [nucleotide binding]; other site 399741003593 thiamine monophosphate kinase; Provisional; Region: PRK05731 399741003594 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 399741003595 ATP binding site [chemical binding]; other site 399741003596 dimerization interface [polypeptide binding]; other site 399741003597 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 399741003598 tetramer interfaces [polypeptide binding]; other site 399741003599 binuclear metal-binding site [ion binding]; other site 399741003600 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 399741003601 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 399741003602 active site 399741003603 catalytic tetrad [active] 399741003604 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 399741003605 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 399741003606 TPP-binding site; other site 399741003607 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 399741003608 PYR/PP interface [polypeptide binding]; other site 399741003609 dimer interface [polypeptide binding]; other site 399741003610 TPP binding site [chemical binding]; other site 399741003611 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 399741003612 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 399741003613 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 399741003614 substrate binding pocket [chemical binding]; other site 399741003615 chain length determination region; other site 399741003616 substrate-Mg2+ binding site; other site 399741003617 catalytic residues [active] 399741003618 aspartate-rich region 1; other site 399741003619 active site lid residues [active] 399741003620 aspartate-rich region 2; other site 399741003621 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 399741003622 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 399741003623 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 399741003624 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 399741003625 Ligand Binding Site [chemical binding]; other site 399741003626 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 399741003627 active site residue [active] 399741003628 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 399741003629 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 399741003630 conserved cys residue [active] 399741003631 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 399741003632 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 399741003633 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 399741003634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 399741003635 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 399741003636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741003637 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741003638 putative substrate translocation pore; other site 399741003639 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 399741003640 UbiA prenyltransferase family; Region: UbiA; pfam01040 399741003641 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 399741003642 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 399741003643 Subunit I/III interface [polypeptide binding]; other site 399741003644 Subunit III/IV interface [polypeptide binding]; other site 399741003645 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 399741003646 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 399741003647 D-pathway; other site 399741003648 Putative ubiquinol binding site [chemical binding]; other site 399741003649 Low-spin heme (heme b) binding site [chemical binding]; other site 399741003650 Putative water exit pathway; other site 399741003651 Binuclear center (heme o3/CuB) [ion binding]; other site 399741003652 K-pathway; other site 399741003653 Putative proton exit pathway; other site 399741003654 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 399741003655 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 399741003656 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 399741003657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741003658 putative substrate translocation pore; other site 399741003659 hypothetical protein; Provisional; Region: PRK11627 399741003660 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 399741003661 transcriptional regulator BolA; Provisional; Region: PRK11628 399741003662 trigger factor; Provisional; Region: tig; PRK01490 399741003663 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 399741003664 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 399741003665 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 399741003666 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 399741003667 oligomer interface [polypeptide binding]; other site 399741003668 active site residues [active] 399741003669 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 399741003670 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 399741003671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741003672 Walker A motif; other site 399741003673 ATP binding site [chemical binding]; other site 399741003674 Walker B motif; other site 399741003675 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 399741003676 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 399741003677 Found in ATP-dependent protease La (LON); Region: LON; smart00464 399741003678 Found in ATP-dependent protease La (LON); Region: LON; smart00464 399741003679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741003680 Walker A motif; other site 399741003681 ATP binding site [chemical binding]; other site 399741003682 Walker B motif; other site 399741003683 arginine finger; other site 399741003684 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 399741003685 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 399741003686 IHF dimer interface [polypeptide binding]; other site 399741003687 IHF - DNA interface [nucleotide binding]; other site 399741003688 periplasmic folding chaperone; Provisional; Region: PRK10788 399741003689 SurA N-terminal domain; Region: SurA_N_3; cl07813 399741003690 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 399741003691 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 399741003692 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 399741003693 active site 399741003694 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 399741003695 Ligand Binding Site [chemical binding]; other site 399741003696 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 399741003697 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 399741003698 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 399741003699 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 399741003700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741003701 active site 399741003702 motif I; other site 399741003703 motif II; other site 399741003704 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741003705 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 399741003706 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 399741003707 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 399741003708 catalytic residue [active] 399741003709 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 399741003710 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 399741003711 putative DNA binding site [nucleotide binding]; other site 399741003712 putative Zn2+ binding site [ion binding]; other site 399741003713 AsnC family; Region: AsnC_trans_reg; pfam01037 399741003714 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 399741003715 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 399741003716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741003717 Walker A/P-loop; other site 399741003718 ATP binding site [chemical binding]; other site 399741003719 Q-loop/lid; other site 399741003720 ABC transporter signature motif; other site 399741003721 Walker B; other site 399741003722 D-loop; other site 399741003723 H-loop/switch region; other site 399741003724 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 399741003725 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 399741003726 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 399741003727 Walker A/P-loop; other site 399741003728 ATP binding site [chemical binding]; other site 399741003729 Q-loop/lid; other site 399741003730 ABC transporter signature motif; other site 399741003731 Walker B; other site 399741003732 D-loop; other site 399741003733 H-loop/switch region; other site 399741003734 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 399741003735 Nitrogen regulatory protein P-II; Region: P-II; smart00938 399741003736 ammonium transporter; Provisional; Region: PRK10666 399741003737 acyl-CoA thioesterase II; Provisional; Region: PRK10526 399741003738 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 399741003739 active site 399741003740 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 399741003741 catalytic triad [active] 399741003742 dimer interface [polypeptide binding]; other site 399741003743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 399741003744 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 399741003745 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 399741003746 DNA binding site [nucleotide binding] 399741003747 active site 399741003748 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 399741003749 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 399741003750 SCP-2 sterol transfer family; Region: SCP2; cl01225 399741003751 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 399741003752 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 399741003753 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 399741003754 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 399741003755 active site 399741003756 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 399741003757 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741003758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741003759 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 399741003760 dimerization interface [polypeptide binding]; other site 399741003761 gene expression modulator; Provisional; Region: PRK10945 399741003762 Hha toxicity attenuator; Provisional; Region: PRK10667 399741003763 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 399741003764 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 399741003765 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 399741003766 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 399741003767 ABC-ATPase subunit interface; other site 399741003768 dimer interface [polypeptide binding]; other site 399741003769 putative PBP binding regions; other site 399741003770 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 399741003771 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 399741003772 metal binding site [ion binding]; metal-binding site 399741003773 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 399741003774 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 399741003775 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 399741003776 Protein export membrane protein; Region: SecD_SecF; cl14618 399741003777 Protein export membrane protein; Region: SecD_SecF; cl14618 399741003778 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 399741003779 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 399741003780 HlyD family secretion protein; Region: HlyD_3; pfam13437 399741003781 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 399741003782 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741003783 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 399741003784 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 399741003785 hypothetical protein; Provisional; Region: PRK11281 399741003786 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 399741003787 Mechanosensitive ion channel; Region: MS_channel; pfam00924 399741003788 hypothetical protein; Provisional; Region: PRK11038 399741003789 Primosomal replication protein priB and priC; Region: priB_priC; pfam07445 399741003790 hypothetical protein; Provisional; Region: PRK10527 399741003791 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 399741003792 active site 399741003793 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 399741003794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741003795 Walker A motif; other site 399741003796 ATP binding site [chemical binding]; other site 399741003797 Walker B motif; other site 399741003798 arginine finger; other site 399741003799 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 399741003800 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 399741003801 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 399741003802 hypothetical protein; Validated; Region: PRK00153 399741003803 recombination protein RecR; Reviewed; Region: recR; PRK00076 399741003804 RecR protein; Region: RecR; pfam02132 399741003805 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 399741003806 putative active site [active] 399741003807 putative metal-binding site [ion binding]; other site 399741003808 tetramer interface [polypeptide binding]; other site 399741003809 heat shock protein 90; Provisional; Region: PRK05218 399741003810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741003811 ATP binding site [chemical binding]; other site 399741003812 Mg2+ binding site [ion binding]; other site 399741003813 G-X-G motif; other site 399741003814 adenylate kinase; Reviewed; Region: adk; PRK00279 399741003815 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 399741003816 AMP-binding site [chemical binding]; other site 399741003817 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 399741003818 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 399741003819 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 399741003820 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 399741003821 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 399741003822 fructuronate transporter; Provisional; Region: PRK10034; cl15264 399741003823 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 399741003824 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 399741003825 ferrochelatase; Reviewed; Region: hemH; PRK00035 399741003826 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 399741003827 C-terminal domain interface [polypeptide binding]; other site 399741003828 active site 399741003829 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 399741003830 active site 399741003831 N-terminal domain interface [polypeptide binding]; other site 399741003832 inosine/guanosine kinase; Provisional; Region: PRK15074 399741003833 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 399741003834 substrate binding site [chemical binding]; other site 399741003835 ATP binding site [chemical binding]; other site 399741003836 putative cation:proton antiport protein; Provisional; Region: PRK10669 399741003837 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 399741003838 TrkA-N domain; Region: TrkA_N; pfam02254 399741003839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741003840 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741003841 putative substrate translocation pore; other site 399741003842 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 399741003843 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 399741003844 active site 399741003845 metal binding site [ion binding]; metal-binding site 399741003846 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 399741003847 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 399741003848 putative deacylase active site [active] 399741003849 TraB family; Region: TraB; cl12050 399741003850 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 399741003851 metal-binding site [ion binding] 399741003852 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 399741003853 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 399741003854 DNA binding residues [nucleotide binding] 399741003855 dimer interface [polypeptide binding]; other site 399741003856 copper binding site [ion binding]; other site 399741003857 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 399741003858 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 399741003859 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 399741003860 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 399741003861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741003862 S-adenosylmethionine binding site [chemical binding]; other site 399741003863 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 399741003864 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 399741003865 oxidoreductase; Provisional; Region: PRK08017 399741003866 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 399741003867 NADP binding site [chemical binding]; other site 399741003868 active site 399741003869 steroid binding site; other site 399741003870 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 399741003871 active site 399741003872 catalytic triad [active] 399741003873 oxyanion hole [active] 399741003874 switch loop; other site 399741003875 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 399741003876 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 399741003877 Walker A/P-loop; other site 399741003878 ATP binding site [chemical binding]; other site 399741003879 Q-loop/lid; other site 399741003880 ABC transporter signature motif; other site 399741003881 Walker B; other site 399741003882 D-loop; other site 399741003883 H-loop/switch region; other site 399741003884 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 399741003885 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 399741003886 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 399741003887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741003888 putative substrate translocation pore; other site 399741003889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741003890 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 399741003891 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 399741003892 NAD binding site [chemical binding]; other site 399741003893 homodimer interface [polypeptide binding]; other site 399741003894 active site 399741003895 substrate binding site [chemical binding]; other site 399741003896 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 399741003897 ATP-grasp domain; Region: ATP-grasp; pfam02222 399741003898 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 399741003899 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 399741003900 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 399741003901 putative active site [active] 399741003902 putative metal binding site [ion binding]; other site 399741003903 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 399741003904 substrate binding site [chemical binding]; other site 399741003905 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 399741003906 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 399741003907 active site 399741003908 HIGH motif; other site 399741003909 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 399741003910 KMSKS motif; other site 399741003911 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 399741003912 tRNA binding surface [nucleotide binding]; other site 399741003913 anticodon binding site; other site 399741003914 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 399741003915 RNA binding surface [nucleotide binding]; other site 399741003916 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 399741003917 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 399741003918 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 399741003919 homodimer interface [polypeptide binding]; other site 399741003920 NADP binding site [chemical binding]; other site 399741003921 substrate binding site [chemical binding]; other site 399741003922 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 399741003923 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 399741003924 catalytic Zn binding site [ion binding]; other site 399741003925 NAD binding site [chemical binding]; other site 399741003926 structural Zn binding site [ion binding]; other site 399741003927 GXWXG protein; Region: GXWXG; pfam14231 399741003928 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 399741003929 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 399741003930 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 399741003931 FMN binding site [chemical binding]; other site 399741003932 active site 399741003933 substrate binding site [chemical binding]; other site 399741003934 catalytic residue [active] 399741003935 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292 399741003936 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 399741003937 putative NAD(P) binding site [chemical binding]; other site 399741003938 putative dimer interface [polypeptide binding]; other site 399741003939 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 399741003940 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 399741003941 catalytic residues [active] 399741003942 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 399741003943 Helix-turn-helix domain; Region: HTH_18; pfam12833 399741003944 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741003945 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 399741003946 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 399741003947 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 399741003948 active site 399741003949 catalytic tetrad [active] 399741003950 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741003951 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741003952 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 399741003953 putative effector binding pocket; other site 399741003954 putative dimerization interface [polypeptide binding]; other site 399741003955 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 399741003956 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 399741003957 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 399741003958 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 399741003959 metal binding site [ion binding]; metal-binding site 399741003960 active site 399741003961 I-site; other site 399741003962 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 399741003963 DNA-binding site [nucleotide binding]; DNA binding site 399741003964 RNA-binding motif; other site 399741003965 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 399741003966 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 399741003967 putative active site [active] 399741003968 putative metal binding site [ion binding]; other site 399741003969 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 399741003970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741003971 Walker A/P-loop; other site 399741003972 ATP binding site [chemical binding]; other site 399741003973 Q-loop/lid; other site 399741003974 ABC transporter signature motif; other site 399741003975 Walker B; other site 399741003976 D-loop; other site 399741003977 H-loop/switch region; other site 399741003978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741003979 dimer interface [polypeptide binding]; other site 399741003980 conserved gate region; other site 399741003981 putative PBP binding loops; other site 399741003982 ABC-ATPase subunit interface; other site 399741003983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741003984 Coenzyme A binding pocket [chemical binding]; other site 399741003985 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 399741003986 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 399741003987 active site 399741003988 non-prolyl cis peptide bond; other site 399741003989 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 399741003990 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 399741003991 metal binding site [ion binding]; metal-binding site 399741003992 dimer interface [polypeptide binding]; other site 399741003993 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 399741003994 DNA-binding site [nucleotide binding]; DNA binding site 399741003995 RNA-binding motif; other site 399741003996 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 399741003997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741003998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 399741003999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741004000 chromosome condensation membrane protein; Provisional; Region: PRK14196 399741004001 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 399741004002 MASE2 domain; Region: MASE2; pfam05230 399741004003 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 399741004004 metal binding site [ion binding]; metal-binding site 399741004005 active site 399741004006 I-site; other site 399741004007 twin arginine translocase protein A; Validated; Region: tatE; PRK01614 399741004008 lipoyl synthase; Provisional; Region: PRK05481 399741004009 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 399741004010 FeS/SAM binding site; other site 399741004011 lipoate-protein ligase B; Provisional; Region: PRK14342 399741004012 hypothetical protein; Provisional; Region: PRK04998 399741004013 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 399741004014 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 399741004015 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 399741004016 rare lipoprotein A; Provisional; Region: PRK10672 399741004017 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 399741004018 Sporulation related domain; Region: SPOR; pfam05036 399741004019 cell wall shape-determining protein; Provisional; Region: PRK10794 399741004020 penicillin-binding protein 2; Provisional; Region: PRK10795 399741004021 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 399741004022 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 399741004023 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 399741004024 ribosome-associated protein; Provisional; Region: PRK11538 399741004025 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 399741004026 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 399741004027 active site 399741004028 (T/H)XGH motif; other site 399741004029 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 399741004030 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 399741004031 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 399741004032 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 399741004033 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 399741004034 HIGH motif; other site 399741004035 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 399741004036 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 399741004037 active site 399741004038 KMSKS motif; other site 399741004039 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 399741004040 tRNA binding surface [nucleotide binding]; other site 399741004041 hypothetical protein; Provisional; Region: PRK11032 399741004042 azoreductase; Reviewed; Region: PRK00170 399741004043 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 399741004044 active site 399741004045 tetramer interface [polypeptide binding]; other site 399741004046 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 399741004047 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 399741004048 Walker A/P-loop; other site 399741004049 ATP binding site [chemical binding]; other site 399741004050 Q-loop/lid; other site 399741004051 ABC transporter signature motif; other site 399741004052 Walker B; other site 399741004053 D-loop; other site 399741004054 H-loop/switch region; other site 399741004055 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 399741004056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741004057 dimer interface [polypeptide binding]; other site 399741004058 conserved gate region; other site 399741004059 putative PBP binding loops; other site 399741004060 ABC-ATPase subunit interface; other site 399741004061 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 399741004062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741004063 dimer interface [polypeptide binding]; other site 399741004064 conserved gate region; other site 399741004065 putative PBP binding loops; other site 399741004066 ABC-ATPase subunit interface; other site 399741004067 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 399741004068 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741004069 substrate binding pocket [chemical binding]; other site 399741004070 membrane-bound complex binding site; other site 399741004071 hinge residues; other site 399741004072 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 399741004073 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 399741004074 putative active site [active] 399741004075 catalytic triad [active] 399741004076 putative dimer interface [polypeptide binding]; other site 399741004077 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 399741004078 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 399741004079 Transporter associated domain; Region: CorC_HlyC; smart01091 399741004080 metal-binding heat shock protein; Provisional; Region: PRK00016 399741004081 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 399741004082 PhoH-like protein; Region: PhoH; pfam02562 399741004083 hypothetical protein; Provisional; Region: PRK10220 399741004084 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 399741004085 PhnA protein; Region: PhnA; pfam03831 399741004086 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 399741004087 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 399741004088 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 399741004089 FeS/SAM binding site; other site 399741004090 TRAM domain; Region: TRAM; pfam01938 399741004091 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 399741004092 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 399741004093 asparagine synthetase B; Provisional; Region: asnB; PRK09431 399741004094 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 399741004095 active site 399741004096 dimer interface [polypeptide binding]; other site 399741004097 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 399741004098 Ligand Binding Site [chemical binding]; other site 399741004099 Molecular Tunnel; other site 399741004100 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 399741004101 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 399741004102 putative active site [active] 399741004103 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 399741004104 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 399741004105 UMP phosphatase; Provisional; Region: PRK10444 399741004106 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741004107 active site 399741004108 motif I; other site 399741004109 motif II; other site 399741004110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741004111 MarR family; Region: MarR; pfam01047 399741004112 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 399741004113 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 399741004114 nucleotide binding site [chemical binding]; other site 399741004115 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 399741004116 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 399741004117 active site 399741004118 dimer interface [polypeptide binding]; other site 399741004119 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 399741004120 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 399741004121 active site 399741004122 trimer interface [polypeptide binding]; other site 399741004123 allosteric site; other site 399741004124 active site lid [active] 399741004125 hexamer (dimer of trimers) interface [polypeptide binding]; other site 399741004126 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 399741004127 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 399741004128 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 399741004129 active site turn [active] 399741004130 phosphorylation site [posttranslational modification] 399741004131 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 399741004132 HPr interaction site; other site 399741004133 glycerol kinase (GK) interaction site [polypeptide binding]; other site 399741004134 active site 399741004135 phosphorylation site [posttranslational modification] 399741004136 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 399741004137 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 399741004138 active site 399741004139 HIGH motif; other site 399741004140 nucleotide binding site [chemical binding]; other site 399741004141 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 399741004142 KMSKS motif; other site 399741004143 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 399741004144 outer membrane porin, OprD family; Region: OprD; pfam03573 399741004145 YbfN-like lipoprotein; Region: YbfN; pfam13982 399741004146 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 399741004147 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 399741004148 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 399741004149 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 399741004150 active site 399741004151 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 399741004152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741004153 sugar efflux transporter; Region: 2A0120; TIGR00899 399741004154 putative substrate translocation pore; other site 399741004155 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 399741004156 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 399741004157 NAD binding site [chemical binding]; other site 399741004158 homodimer interface [polypeptide binding]; other site 399741004159 active site 399741004160 substrate binding site [chemical binding]; other site 399741004161 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 399741004162 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 399741004163 ferric uptake regulator; Provisional; Region: fur; PRK09462 399741004164 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 399741004165 metal binding site 2 [ion binding]; metal-binding site 399741004166 putative DNA binding helix; other site 399741004167 metal binding site 1 [ion binding]; metal-binding site 399741004168 dimer interface [polypeptide binding]; other site 399741004169 structural Zn2+ binding site [ion binding]; other site 399741004170 flavodoxin FldA; Validated; Region: PRK09267 399741004171 LexA regulated protein; Provisional; Region: PRK11675 399741004172 acyl-CoA esterase; Provisional; Region: PRK10673 399741004173 PGAP1-like protein; Region: PGAP1; pfam07819 399741004174 replication initiation regulator SeqA; Provisional; Region: PRK11187 399741004175 phosphoglucomutase; Validated; Region: PRK07564 399741004176 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 399741004177 active site 399741004178 substrate binding site [chemical binding]; other site 399741004179 metal binding site [ion binding]; metal-binding site 399741004180 Predicted transcriptional regulators [Transcription]; Region: COG1695 399741004181 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 399741004182 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 399741004183 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 399741004184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741004185 active site 399741004186 phosphorylation site [posttranslational modification] 399741004187 intermolecular recognition site; other site 399741004188 dimerization interface [polypeptide binding]; other site 399741004189 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741004190 DNA binding site [nucleotide binding] 399741004191 sensor protein KdpD; Provisional; Region: PRK10490 399741004192 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 399741004193 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 399741004194 Ligand Binding Site [chemical binding]; other site 399741004195 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 399741004196 GAF domain; Region: GAF_3; pfam13492 399741004197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741004198 dimer interface [polypeptide binding]; other site 399741004199 phosphorylation site [posttranslational modification] 399741004200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741004201 ATP binding site [chemical binding]; other site 399741004202 Mg2+ binding site [ion binding]; other site 399741004203 G-X-G motif; other site 399741004204 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 399741004205 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 399741004206 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 399741004207 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 399741004208 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 399741004209 Protein of unknown function (DUF523); Region: DUF523; pfam04463 399741004210 Uncharacterized conserved protein [Function unknown]; Region: COG3272 399741004211 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 399741004212 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 399741004213 DNA photolyase; Region: DNA_photolyase; pfam00875 399741004214 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 399741004215 Uncharacterized conserved protein [Function unknown]; Region: COG0327 399741004216 metal-binding protein; Provisional; Region: PRK10799 399741004217 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 399741004218 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 399741004219 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 399741004220 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 399741004221 putative active site [active] 399741004222 Protein of unknown function (DUF969); Region: DUF969; pfam06149 399741004223 Predicted membrane protein [Function unknown]; Region: COG3817 399741004224 Protein of unknown function (DUF979); Region: DUF979; pfam06166 399741004225 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 399741004226 putative substrate binding pocket [chemical binding]; other site 399741004227 AC domain interface; other site 399741004228 catalytic triad [active] 399741004229 AB domain interface; other site 399741004230 endonuclease VIII; Provisional; Region: PRK10445 399741004231 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 399741004232 DNA binding site [nucleotide binding] 399741004233 catalytic residue [active] 399741004234 H2TH interface [polypeptide binding]; other site 399741004235 putative catalytic residues [active] 399741004236 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 399741004237 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 399741004238 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 399741004239 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 399741004240 dimer interface [polypeptide binding]; other site 399741004241 active site 399741004242 citrylCoA binding site [chemical binding]; other site 399741004243 NADH binding [chemical binding]; other site 399741004244 cationic pore residues; other site 399741004245 oxalacetate/citrate binding site [chemical binding]; other site 399741004246 coenzyme A binding site [chemical binding]; other site 399741004247 catalytic triad [active] 399741004248 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 399741004249 Iron-sulfur protein interface; other site 399741004250 proximal quinone binding site [chemical binding]; other site 399741004251 SdhD (CybS) interface [polypeptide binding]; other site 399741004252 proximal heme binding site [chemical binding]; other site 399741004253 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 399741004254 SdhC subunit interface [polypeptide binding]; other site 399741004255 proximal heme binding site [chemical binding]; other site 399741004256 cardiolipin binding site; other site 399741004257 Iron-sulfur protein interface; other site 399741004258 proximal quinone binding site [chemical binding]; other site 399741004259 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 399741004260 L-aspartate oxidase; Provisional; Region: PRK06175 399741004261 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 399741004262 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 399741004263 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 399741004264 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 399741004265 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 399741004266 TPP-binding site [chemical binding]; other site 399741004267 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 399741004268 dimer interface [polypeptide binding]; other site 399741004269 PYR/PP interface [polypeptide binding]; other site 399741004270 TPP binding site [chemical binding]; other site 399741004271 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 399741004272 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 399741004273 E3 interaction surface; other site 399741004274 lipoyl attachment site [posttranslational modification]; other site 399741004275 e3 binding domain; Region: E3_binding; pfam02817 399741004276 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 399741004277 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 399741004278 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 399741004279 CoA-ligase; Region: Ligase_CoA; pfam00549 399741004280 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 399741004281 CoA binding domain; Region: CoA_binding; smart00881 399741004282 CoA-ligase; Region: Ligase_CoA; pfam00549 399741004283 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 399741004284 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 399741004285 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 399741004286 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 399741004287 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 399741004288 hypothetical protein; Provisional; Region: PRK10588 399741004289 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 399741004290 active site 399741004291 colicin uptake protein TolQ; Provisional; Region: PRK10801 399741004292 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 399741004293 colicin uptake protein TolR; Provisional; Region: PRK11024 399741004294 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 399741004295 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 399741004296 TolA C-terminal; Region: TolA; pfam06519 399741004297 translocation protein TolB; Provisional; Region: tolB; PRK03629 399741004298 TolB amino-terminal domain; Region: TolB_N; pfam04052 399741004299 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 399741004300 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 399741004301 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 399741004302 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 399741004303 Serglycin; Region: Serglycin; pfam04360 399741004304 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 399741004305 ligand binding site [chemical binding]; other site 399741004306 tol-pal system protein YbgF; Provisional; Region: PRK10803 399741004307 Tetratricopeptide repeat; Region: TPR_6; pfam13174 399741004308 quinolinate synthetase; Provisional; Region: PRK09375 399741004309 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 399741004310 zinc transporter ZitB; Provisional; Region: PRK03557 399741004311 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741004312 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 399741004313 substrate binding pocket [chemical binding]; other site 399741004314 membrane-bound complex binding site; other site 399741004315 hinge residues; other site 399741004316 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 399741004317 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741004318 substrate binding pocket [chemical binding]; other site 399741004319 membrane-bound complex binding site; other site 399741004320 hinge residues; other site 399741004321 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 399741004322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741004323 dimer interface [polypeptide binding]; other site 399741004324 phosphorylation site [posttranslational modification] 399741004325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741004326 ATP binding site [chemical binding]; other site 399741004327 Mg2+ binding site [ion binding]; other site 399741004328 G-X-G motif; other site 399741004329 Response regulator receiver domain; Region: Response_reg; pfam00072 399741004330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741004331 active site 399741004332 phosphorylation site [posttranslational modification] 399741004333 intermolecular recognition site; other site 399741004334 dimerization interface [polypeptide binding]; other site 399741004335 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 399741004336 putative binding surface; other site 399741004337 active site 399741004338 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 399741004339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741004340 active site 399741004341 phosphorylation site [posttranslational modification] 399741004342 intermolecular recognition site; other site 399741004343 dimerization interface [polypeptide binding]; other site 399741004344 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741004345 DNA binding residues [nucleotide binding] 399741004346 dimerization interface [polypeptide binding]; other site 399741004347 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 399741004348 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 399741004349 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 399741004350 catalytic core [active] 399741004351 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 399741004352 psiF repeat; Region: PsiF_repeat; pfam07769 399741004353 psiF repeat; Region: PsiF_repeat; pfam07769 399741004354 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 399741004355 active site 399741004356 catalytic residues [active] 399741004357 galactokinase; Provisional; Region: PRK05101 399741004358 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 399741004359 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 399741004360 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 399741004361 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 399741004362 dimer interface [polypeptide binding]; other site 399741004363 active site 399741004364 CAAX protease self-immunity; Region: Abi; pfam02517 399741004365 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 399741004366 catalytic triad [active] 399741004367 conserved cis-peptide bond; other site 399741004368 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 399741004369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 399741004370 Walker A/P-loop; other site 399741004371 ATP binding site [chemical binding]; other site 399741004372 Q-loop/lid; other site 399741004373 ABC transporter signature motif; other site 399741004374 Walker B; other site 399741004375 D-loop; other site 399741004376 H-loop/switch region; other site 399741004377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741004378 Walker A/P-loop; other site 399741004379 ATP binding site [chemical binding]; other site 399741004380 Q-loop/lid; other site 399741004381 ABC transporter signature motif; other site 399741004382 Walker B; other site 399741004383 D-loop; other site 399741004384 H-loop/switch region; other site 399741004385 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 399741004386 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 399741004387 molybdenum-pterin binding domain; Region: Mop; TIGR00638 399741004388 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 399741004389 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 399741004390 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 399741004391 N-terminal plug; other site 399741004392 ligand-binding site [chemical binding]; other site 399741004393 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 399741004394 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 399741004395 intersubunit interface [polypeptide binding]; other site 399741004396 Methyltransferase domain; Region: Methyltransf_31; pfam13847 399741004397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741004398 S-adenosylmethionine binding site [chemical binding]; other site 399741004399 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 399741004400 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 399741004401 dimer interface [polypeptide binding]; other site 399741004402 putative PBP binding regions; other site 399741004403 ABC-ATPase subunit interface; other site 399741004404 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 399741004405 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 399741004406 Walker A/P-loop; other site 399741004407 ATP binding site [chemical binding]; other site 399741004408 Q-loop/lid; other site 399741004409 ABC transporter signature motif; other site 399741004410 Walker B; other site 399741004411 D-loop; other site 399741004412 H-loop/switch region; other site 399741004413 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 399741004414 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 399741004415 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 399741004416 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 399741004417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741004418 dimer interface [polypeptide binding]; other site 399741004419 conserved gate region; other site 399741004420 putative PBP binding loops; other site 399741004421 ABC-ATPase subunit interface; other site 399741004422 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 399741004423 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741004424 Walker A/P-loop; other site 399741004425 ATP binding site [chemical binding]; other site 399741004426 Q-loop/lid; other site 399741004427 ABC transporter signature motif; other site 399741004428 Walker B; other site 399741004429 D-loop; other site 399741004430 H-loop/switch region; other site 399741004431 molybdenum-pterin binding domain; Region: Mop; TIGR00638 399741004432 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 399741004433 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741004434 6-phosphogluconolactonase; Provisional; Region: PRK11028 399741004435 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 399741004436 substrate binding site [chemical binding]; other site 399741004437 Uncharacterized conserved protein [Function unknown]; Region: COG3339 399741004438 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 399741004439 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 399741004440 inhibitor-cofactor binding pocket; inhibition site 399741004441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741004442 catalytic residue [active] 399741004443 biotin synthase; Provisional; Region: PRK15108 399741004444 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 399741004445 FeS/SAM binding site; other site 399741004446 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 399741004447 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 399741004448 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 399741004449 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 399741004450 catalytic residue [active] 399741004451 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 399741004452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741004453 S-adenosylmethionine binding site [chemical binding]; other site 399741004454 AAA domain; Region: AAA_26; pfam13500 399741004455 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 399741004456 ADP binding site [chemical binding]; other site 399741004457 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 399741004458 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 399741004459 Walker A/P-loop; other site 399741004460 ATP binding site [chemical binding]; other site 399741004461 Q-loop/lid; other site 399741004462 ABC transporter signature motif; other site 399741004463 Walker B; other site 399741004464 D-loop; other site 399741004465 H-loop/switch region; other site 399741004466 excinuclease ABC subunit B; Provisional; Region: PRK05298 399741004467 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 399741004468 ATP binding site [chemical binding]; other site 399741004469 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 399741004470 nucleotide binding region [chemical binding]; other site 399741004471 ATP-binding site [chemical binding]; other site 399741004472 Ultra-violet resistance protein B; Region: UvrB; pfam12344 399741004473 UvrB/uvrC motif; Region: UVR; pfam02151 399741004474 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 399741004475 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 399741004476 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 399741004477 phosphate binding site [ion binding]; other site 399741004478 putative substrate binding pocket [chemical binding]; other site 399741004479 dimer interface [polypeptide binding]; other site 399741004480 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 399741004481 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 399741004482 FeS/SAM binding site; other site 399741004483 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 399741004484 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 399741004485 MPT binding site; other site 399741004486 trimer interface [polypeptide binding]; other site 399741004487 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 399741004488 trimer interface [polypeptide binding]; other site 399741004489 dimer interface [polypeptide binding]; other site 399741004490 putative active site [active] 399741004491 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 399741004492 MoaE interaction surface [polypeptide binding]; other site 399741004493 MoeB interaction surface [polypeptide binding]; other site 399741004494 thiocarboxylated glycine; other site 399741004495 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 399741004496 MoaE homodimer interface [polypeptide binding]; other site 399741004497 MoaD interaction [polypeptide binding]; other site 399741004498 active site residues [active] 399741004499 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 399741004500 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 399741004501 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 399741004502 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 399741004503 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 399741004504 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 399741004505 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 399741004506 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 399741004507 Walker A/P-loop; other site 399741004508 ATP binding site [chemical binding]; other site 399741004509 Q-loop/lid; other site 399741004510 ABC transporter signature motif; other site 399741004511 Walker B; other site 399741004512 D-loop; other site 399741004513 H-loop/switch region; other site 399741004514 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 399741004515 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 399741004516 Walker A/P-loop; other site 399741004517 ATP binding site [chemical binding]; other site 399741004518 Q-loop/lid; other site 399741004519 ABC transporter signature motif; other site 399741004520 Walker B; other site 399741004521 D-loop; other site 399741004522 H-loop/switch region; other site 399741004523 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 399741004524 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 399741004525 HlyD family secretion protein; Region: HlyD_3; pfam13437 399741004526 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 399741004527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741004528 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 399741004529 helicase 45; Provisional; Region: PTZ00424 399741004530 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 399741004531 ATP binding site [chemical binding]; other site 399741004532 Mg++ binding site [ion binding]; other site 399741004533 motif III; other site 399741004534 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 399741004535 nucleotide binding region [chemical binding]; other site 399741004536 ATP-binding site [chemical binding]; other site 399741004537 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 399741004538 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 399741004539 HlyD family secretion protein; Region: HlyD_3; pfam13437 399741004540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741004541 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741004542 putative substrate translocation pore; other site 399741004543 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 399741004544 Transcriptional regulator [Transcription]; Region: IclR; COG1414 399741004545 Bacterial transcriptional regulator; Region: IclR; pfam01614 399741004546 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 399741004547 Ligand Binding Site [chemical binding]; other site 399741004548 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 399741004549 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 399741004550 dimerization interface [polypeptide binding]; other site 399741004551 NAD binding site [chemical binding]; other site 399741004552 ligand binding site [chemical binding]; other site 399741004553 catalytic site [active] 399741004554 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 399741004555 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 399741004556 FMN binding site [chemical binding]; other site 399741004557 active site 399741004558 catalytic residues [active] 399741004559 substrate binding site [chemical binding]; other site 399741004560 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 399741004561 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741004562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741004563 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741004564 dimerization interface [polypeptide binding]; other site 399741004565 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 399741004566 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741004567 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 399741004568 dimerization interface [polypeptide binding]; other site 399741004569 substrate binding pocket [chemical binding]; other site 399741004570 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 399741004571 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 399741004572 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 399741004573 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 399741004574 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741004575 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 399741004576 dimerization interface [polypeptide binding]; other site 399741004577 substrate binding pocket [chemical binding]; other site 399741004578 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 399741004579 L-asparagine permease; Provisional; Region: PRK15049 399741004580 Predicted membrane protein [Function unknown]; Region: COG4125 399741004581 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 399741004582 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 399741004583 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741004584 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741004585 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 399741004586 dimerization interface [polypeptide binding]; other site 399741004587 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 399741004588 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 399741004589 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 399741004590 NAD binding site [chemical binding]; other site 399741004591 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 399741004592 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 399741004593 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 399741004594 dimer interface [polypeptide binding]; other site 399741004595 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 399741004596 Protein of unknown function (DUF808); Region: DUF808; pfam05661 399741004597 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 399741004598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741004599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 399741004600 Coenzyme A binding pocket [chemical binding]; other site 399741004601 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 399741004602 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 399741004603 DNA binding residues [nucleotide binding] 399741004604 putative dimer interface [polypeptide binding]; other site 399741004605 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 399741004606 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 399741004607 PemK-like protein; Region: PemK; cl00995 399741004608 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 399741004609 lipoprotein, YaeC family; Region: TIGR00363 399741004610 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 399741004611 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 399741004612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741004613 Coenzyme A binding pocket [chemical binding]; other site 399741004614 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 399741004615 putative trimer interface [polypeptide binding]; other site 399741004616 putative active site [active] 399741004617 putative substrate binding site [chemical binding]; other site 399741004618 putative CoA binding site [chemical binding]; other site 399741004619 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 399741004620 D-lactate dehydrogenase; Provisional; Region: PRK11183 399741004621 FAD binding domain; Region: FAD_binding_4; pfam01565 399741004622 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 399741004623 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 399741004624 active site 399741004625 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 399741004626 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 399741004627 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 399741004628 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 399741004629 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 399741004630 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741004631 substrate binding pocket [chemical binding]; other site 399741004632 membrane-bound complex binding site; other site 399741004633 hinge residues; other site 399741004634 putative aminotransferase; Provisional; Region: PRK12414 399741004635 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741004636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741004637 homodimer interface [polypeptide binding]; other site 399741004638 catalytic residue [active] 399741004639 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 399741004640 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741004641 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 399741004642 dimerization interface [polypeptide binding]; other site 399741004643 substrate binding pocket [chemical binding]; other site 399741004644 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 399741004645 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 399741004646 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 399741004647 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 399741004648 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 399741004649 putative ligand binding residues [chemical binding]; other site 399741004650 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 399741004651 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 399741004652 ABC-ATPase subunit interface; other site 399741004653 dimer interface [polypeptide binding]; other site 399741004654 putative PBP binding regions; other site 399741004655 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 399741004656 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741004657 Walker A/P-loop; other site 399741004658 ATP binding site [chemical binding]; other site 399741004659 Q-loop/lid; other site 399741004660 ABC transporter signature motif; other site 399741004661 Walker B; other site 399741004662 D-loop; other site 399741004663 H-loop/switch region; other site 399741004664 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 399741004665 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 399741004666 ParA-like protein; Provisional; Region: PHA02518 399741004667 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 399741004668 P-loop; other site 399741004669 Magnesium ion binding site [ion binding]; other site 399741004670 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 399741004671 active site 399741004672 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 399741004673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741004674 Coenzyme A binding pocket [chemical binding]; other site 399741004675 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741004676 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741004677 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 399741004678 putative effector binding pocket; other site 399741004679 putative dimerization interface [polypeptide binding]; other site 399741004680 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 399741004681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741004682 putative substrate translocation pore; other site 399741004683 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 399741004684 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 399741004685 putative N- and C-terminal domain interface [polypeptide binding]; other site 399741004686 putative active site [active] 399741004687 putative MgATP binding site [chemical binding]; other site 399741004688 catalytic site [active] 399741004689 metal binding site [ion binding]; metal-binding site 399741004690 putative carbohydrate binding site [chemical binding]; other site 399741004691 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 399741004692 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 399741004693 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 399741004694 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 399741004695 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741004696 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741004697 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 399741004698 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 399741004699 ATP binding site [chemical binding]; other site 399741004700 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 399741004701 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 399741004702 active site 399741004703 Na/Ca binding site [ion binding]; other site 399741004704 catalytic site [active] 399741004705 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 399741004706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 399741004707 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 399741004708 Transcriptional regulators [Transcription]; Region: MarR; COG1846 399741004709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741004710 Coenzyme A binding pocket [chemical binding]; other site 399741004711 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 399741004712 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 399741004713 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 399741004714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741004715 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 399741004716 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 399741004717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741004718 dimer interface [polypeptide binding]; other site 399741004719 conserved gate region; other site 399741004720 putative PBP binding loops; other site 399741004721 ABC-ATPase subunit interface; other site 399741004722 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 399741004723 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 399741004724 Walker A/P-loop; other site 399741004725 ATP binding site [chemical binding]; other site 399741004726 Q-loop/lid; other site 399741004727 ABC transporter signature motif; other site 399741004728 Walker B; other site 399741004729 D-loop; other site 399741004730 H-loop/switch region; other site 399741004731 NIL domain; Region: NIL; pfam09383 399741004732 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 399741004733 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741004734 Coenzyme A binding pocket [chemical binding]; other site 399741004735 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741004736 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741004737 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 399741004738 putative effector binding pocket; other site 399741004739 putative dimerization interface [polypeptide binding]; other site 399741004740 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 399741004741 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 399741004742 NADP binding site [chemical binding]; other site 399741004743 dimer interface [polypeptide binding]; other site 399741004744 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 399741004745 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 399741004746 Isochorismatase family; Region: Isochorismatase; pfam00857 399741004747 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 399741004748 catalytic triad [active] 399741004749 conserved cis-peptide bond; other site 399741004750 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 399741004751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 399741004752 NAD(P) binding site [chemical binding]; other site 399741004753 active site 399741004754 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 399741004755 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741004756 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 399741004757 dimerization interface [polypeptide binding]; other site 399741004758 substrate binding pocket [chemical binding]; other site 399741004759 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 399741004760 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 399741004761 active site 399741004762 HIGH motif; other site 399741004763 dimer interface [polypeptide binding]; other site 399741004764 KMSKS motif; other site 399741004765 D-galactonate transporter; Region: 2A0114; TIGR00893 399741004766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741004767 putative substrate translocation pore; other site 399741004768 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741004769 DNA-binding site [nucleotide binding]; DNA binding site 399741004770 Transcriptional regulators [Transcription]; Region: GntR; COG1802 399741004771 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 399741004772 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 399741004773 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 399741004774 putative NAD(P) binding site [chemical binding]; other site 399741004775 catalytic Zn binding site [ion binding]; other site 399741004776 structural Zn binding site [ion binding]; other site 399741004777 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 399741004778 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 399741004779 Walker A/P-loop; other site 399741004780 ATP binding site [chemical binding]; other site 399741004781 Q-loop/lid; other site 399741004782 ABC transporter signature motif; other site 399741004783 Walker B; other site 399741004784 D-loop; other site 399741004785 H-loop/switch region; other site 399741004786 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 399741004787 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 399741004788 substrate binding pocket [chemical binding]; other site 399741004789 membrane-bound complex binding site; other site 399741004790 hinge residues; other site 399741004791 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 399741004792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741004793 dimer interface [polypeptide binding]; other site 399741004794 conserved gate region; other site 399741004795 putative PBP binding loops; other site 399741004796 ABC-ATPase subunit interface; other site 399741004797 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 399741004798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741004799 dimer interface [polypeptide binding]; other site 399741004800 conserved gate region; other site 399741004801 putative PBP binding loops; other site 399741004802 ABC-ATPase subunit interface; other site 399741004803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 399741004804 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 399741004805 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 399741004806 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 399741004807 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 399741004808 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 399741004809 dimer interface [polypeptide binding]; other site 399741004810 putative CheW interface [polypeptide binding]; other site 399741004811 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 399741004812 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 399741004813 Sulfate transporter family; Region: Sulfate_transp; pfam00916 399741004814 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 399741004815 active site clefts [active] 399741004816 zinc binding site [ion binding]; other site 399741004817 dimer interface [polypeptide binding]; other site 399741004818 allophanate hydrolase; Provisional; Region: PRK08186 399741004819 Amidase; Region: Amidase; cl11426 399741004820 urea carboxylase; Region: urea_carbox; TIGR02712 399741004821 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 399741004822 ATP-grasp domain; Region: ATP-grasp_4; cl17255 399741004823 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 399741004824 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 399741004825 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 399741004826 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 399741004827 carboxyltransferase (CT) interaction site; other site 399741004828 biotinylation site [posttranslational modification]; other site 399741004829 Transcriptional regulators [Transcription]; Region: GntR; COG1802 399741004830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741004831 DNA-binding site [nucleotide binding]; DNA binding site 399741004832 FCD domain; Region: FCD; pfam07729 399741004833 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 399741004834 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 399741004835 putative ligand binding site [chemical binding]; other site 399741004836 HEAT repeats; Region: HEAT_2; pfam13646 399741004837 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 399741004838 TM-ABC transporter signature motif; other site 399741004839 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 399741004840 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 399741004841 TM-ABC transporter signature motif; other site 399741004842 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 399741004843 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 399741004844 Walker A/P-loop; other site 399741004845 ATP binding site [chemical binding]; other site 399741004846 Q-loop/lid; other site 399741004847 ABC transporter signature motif; other site 399741004848 Walker B; other site 399741004849 D-loop; other site 399741004850 H-loop/switch region; other site 399741004851 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 399741004852 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 399741004853 Walker A/P-loop; other site 399741004854 ATP binding site [chemical binding]; other site 399741004855 Q-loop/lid; other site 399741004856 ABC transporter signature motif; other site 399741004857 Walker B; other site 399741004858 D-loop; other site 399741004859 H-loop/switch region; other site 399741004860 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 399741004861 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 399741004862 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 399741004863 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 399741004864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741004865 Coenzyme A binding pocket [chemical binding]; other site 399741004866 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 399741004867 hypothetical protein; Provisional; Region: PRK06185 399741004868 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 399741004869 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 399741004870 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741004871 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741004872 dimerization interface [polypeptide binding]; other site 399741004873 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 399741004874 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 399741004875 active site residue [active] 399741004876 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 399741004877 active site residue [active] 399741004878 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 399741004879 Virulence factor SrfB; Region: SrfB; pfam07520 399741004880 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 399741004881 nudix motif; other site 399741004882 Uncharacterized conserved protein [Function unknown]; Region: COG1683 399741004883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 399741004884 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 399741004885 Helix-turn-helix domain; Region: HTH_18; pfam12833 399741004886 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 399741004887 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741004888 DNA-binding site [nucleotide binding]; DNA binding site 399741004889 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741004890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741004891 homodimer interface [polypeptide binding]; other site 399741004892 catalytic residue [active] 399741004893 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 399741004894 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 399741004895 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 399741004896 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 399741004897 benzoate transport; Region: 2A0115; TIGR00895 399741004898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741004899 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 399741004900 Fatty acid desaturase; Region: FA_desaturase; pfam00487 399741004901 putative di-iron ligands [ion binding]; other site 399741004902 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 399741004903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741004904 dimer interface [polypeptide binding]; other site 399741004905 conserved gate region; other site 399741004906 ABC-ATPase subunit interface; other site 399741004907 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 399741004908 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 399741004909 Walker A/P-loop; other site 399741004910 ATP binding site [chemical binding]; other site 399741004911 Q-loop/lid; other site 399741004912 ABC transporter signature motif; other site 399741004913 Walker B; other site 399741004914 D-loop; other site 399741004915 H-loop/switch region; other site 399741004916 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 399741004917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741004918 putative PBP binding loops; other site 399741004919 dimer interface [polypeptide binding]; other site 399741004920 ABC-ATPase subunit interface; other site 399741004921 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 399741004922 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 399741004923 EamA-like transporter family; Region: EamA; pfam00892 399741004924 EamA-like transporter family; Region: EamA; pfam00892 399741004925 Predicted transcriptional regulator [Transcription]; Region: COG2345 399741004926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741004927 putative substrate translocation pore; other site 399741004928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741004929 non-specific DNA binding site [nucleotide binding]; other site 399741004930 salt bridge; other site 399741004931 sequence-specific DNA binding site [nucleotide binding]; other site 399741004932 Cupin domain; Region: Cupin_2; pfam07883 399741004933 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 399741004934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741004935 Coenzyme A binding pocket [chemical binding]; other site 399741004936 Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503 399741004937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741004938 Coenzyme A binding pocket [chemical binding]; other site 399741004939 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 399741004940 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 399741004941 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 399741004942 trimer interface [polypeptide binding]; other site 399741004943 eyelet of channel; other site 399741004944 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 399741004945 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 399741004946 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 399741004947 DEAD_2; Region: DEAD_2; pfam06733 399741004948 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 399741004949 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 399741004950 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 399741004951 putative DNA binding site [nucleotide binding]; other site 399741004952 putative Zn2+ binding site [ion binding]; other site 399741004953 AsnC family; Region: AsnC_trans_reg; pfam01037 399741004954 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 399741004955 EamA-like transporter family; Region: EamA; pfam00892 399741004956 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741004957 salt bridge; other site 399741004958 non-specific DNA binding site [nucleotide binding]; other site 399741004959 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 399741004960 sequence-specific DNA binding site [nucleotide binding]; other site 399741004961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741004962 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 399741004963 putative substrate translocation pore; other site 399741004964 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 399741004965 glycosyl transferase family protein; Provisional; Region: PRK08136 399741004966 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 399741004967 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 399741004968 active site 399741004969 Zn binding site [ion binding]; other site 399741004970 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 399741004971 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 399741004972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741004973 S-adenosylmethionine binding site [chemical binding]; other site 399741004974 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 399741004975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 399741004976 PAS domain; Region: PAS_9; pfam13426 399741004977 putative active site [active] 399741004978 heme pocket [chemical binding]; other site 399741004979 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 399741004980 PAS domain; Region: PAS_9; pfam13426 399741004981 putative active site [active] 399741004982 heme pocket [chemical binding]; other site 399741004983 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 399741004984 dimer interface [polypeptide binding]; other site 399741004985 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 399741004986 putative CheW interface [polypeptide binding]; other site 399741004987 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 399741004988 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741004989 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 399741004990 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741004991 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 399741004992 Coenzyme A binding pocket [chemical binding]; other site 399741004993 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 399741004994 putative mechanosensitive channel protein; Provisional; Region: PRK11465 399741004995 Mechanosensitive ion channel; Region: MS_channel; pfam00924 399741004996 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 399741004997 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 399741004998 Walker A/P-loop; other site 399741004999 ATP binding site [chemical binding]; other site 399741005000 Q-loop/lid; other site 399741005001 ABC transporter signature motif; other site 399741005002 Walker B; other site 399741005003 D-loop; other site 399741005004 H-loop/switch region; other site 399741005005 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 399741005006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741005007 dimer interface [polypeptide binding]; other site 399741005008 conserved gate region; other site 399741005009 putative PBP binding loops; other site 399741005010 ABC-ATPase subunit interface; other site 399741005011 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 399741005012 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741005013 substrate binding pocket [chemical binding]; other site 399741005014 membrane-bound complex binding site; other site 399741005015 hinge residues; other site 399741005016 hypothetical protein; Provisional; Region: PRK11019 399741005017 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 399741005018 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 399741005019 dimerization interface [polypeptide binding]; other site 399741005020 DPS ferroxidase diiron center [ion binding]; other site 399741005021 ion pore; other site 399741005022 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 399741005023 threonine and homoserine efflux system; Provisional; Region: PRK10532 399741005024 EamA-like transporter family; Region: EamA; pfam00892 399741005025 outer membrane protein X; Provisional; Region: ompX; PRK09408 399741005026 Predicted amidohydrolase [General function prediction only]; Region: COG0388 399741005027 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585 399741005028 putative active site [active] 399741005029 catalytic triad [active] 399741005030 putative dimer interface [polypeptide binding]; other site 399741005031 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741005032 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741005033 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 399741005034 dimerization interface [polypeptide binding]; other site 399741005035 substrate binding pocket [chemical binding]; other site 399741005036 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 399741005037 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 399741005038 putative transporter; Provisional; Region: PRK09821 399741005039 GntP family permease; Region: GntP_permease; pfam02447 399741005040 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 399741005041 putative aldolase; Validated; Region: PRK08130 399741005042 intersubunit interface [polypeptide binding]; other site 399741005043 active site 399741005044 Zn2+ binding site [ion binding]; other site 399741005045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 399741005046 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 399741005047 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 399741005048 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 399741005049 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 399741005050 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 399741005051 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 399741005052 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 399741005053 Moco binding site; other site 399741005054 metal coordination site [ion binding]; other site 399741005055 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 399741005056 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 399741005057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741005058 active site 399741005059 phosphorylation site [posttranslational modification] 399741005060 intermolecular recognition site; other site 399741005061 dimerization interface [polypeptide binding]; other site 399741005062 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741005063 DNA binding site [nucleotide binding] 399741005064 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 399741005065 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 399741005066 dimerization interface [polypeptide binding]; other site 399741005067 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741005068 dimer interface [polypeptide binding]; other site 399741005069 phosphorylation site [posttranslational modification] 399741005070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741005071 ATP binding site [chemical binding]; other site 399741005072 Mg2+ binding site [ion binding]; other site 399741005073 G-X-G motif; other site 399741005074 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 399741005075 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741005076 DNA binding site [nucleotide binding] 399741005077 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 399741005078 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741005079 DNA binding residues [nucleotide binding] 399741005080 putative fimbrial protein TcfA; Provisional; Region: PRK15308 399741005081 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 399741005082 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 399741005083 putative fimbrial protein TcfA; Provisional; Region: PRK15308 399741005084 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 399741005085 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 399741005086 dimerization interface [polypeptide binding]; other site 399741005087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741005088 dimer interface [polypeptide binding]; other site 399741005089 phosphorylation site [posttranslational modification] 399741005090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741005091 ATP binding site [chemical binding]; other site 399741005092 Mg2+ binding site [ion binding]; other site 399741005093 G-X-G motif; other site 399741005094 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 399741005095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741005096 active site 399741005097 phosphorylation site [posttranslational modification] 399741005098 intermolecular recognition site; other site 399741005099 dimerization interface [polypeptide binding]; other site 399741005100 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741005101 DNA binding site [nucleotide binding] 399741005102 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 399741005103 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 399741005104 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 399741005105 Moco binding site; other site 399741005106 metal coordination site [ion binding]; other site 399741005107 choline transport protein BetT; Provisional; Region: PRK09928 399741005108 transcriptional regulator BetI; Validated; Region: PRK00767 399741005109 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741005110 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 399741005111 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 399741005112 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 399741005113 tetrameric interface [polypeptide binding]; other site 399741005114 NAD binding site [chemical binding]; other site 399741005115 catalytic residues [active] 399741005116 choline dehydrogenase; Validated; Region: PRK02106 399741005117 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 399741005118 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 399741005119 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 399741005120 active site 399741005121 FMN binding site [chemical binding]; other site 399741005122 substrate binding site [chemical binding]; other site 399741005123 3Fe-4S cluster binding site [ion binding]; other site 399741005124 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 399741005125 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 399741005126 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 399741005127 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 399741005128 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 399741005129 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 399741005130 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 399741005131 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 399741005132 PapC N-terminal domain; Region: PapC_N; pfam13954 399741005133 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 399741005134 PapC C-terminal domain; Region: PapC_C; pfam13953 399741005135 Fimbrial protein; Region: Fimbrial; pfam00419 399741005136 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 399741005137 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741005138 malate:quinone oxidoreductase; Validated; Region: PRK05257 399741005139 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 399741005140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 399741005141 NADH(P)-binding; Region: NAD_binding_10; pfam13460 399741005142 NAD(P) binding site [chemical binding]; other site 399741005143 active site 399741005144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 399741005145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741005146 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 399741005147 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 399741005148 alkaline phosphatase; Provisional; Region: PRK10518 399741005149 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 399741005150 dimer interface [polypeptide binding]; other site 399741005151 active site 399741005152 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 399741005153 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 399741005154 C-terminal domain interface [polypeptide binding]; other site 399741005155 GSH binding site (G-site) [chemical binding]; other site 399741005156 dimer interface [polypeptide binding]; other site 399741005157 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 399741005158 dimer interface [polypeptide binding]; other site 399741005159 N-terminal domain interface [polypeptide binding]; other site 399741005160 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 399741005161 AAA domain; Region: AAA_33; pfam13671 399741005162 AAA domain; Region: AAA_17; pfam13207 399741005163 Uncharacterized protein conserved in bacteria (DUF2084); Region: DUF2084; pfam09857 399741005164 cyanate hydratase; Validated; Region: PRK02866 399741005165 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 399741005166 oligomer interface [polypeptide binding]; other site 399741005167 active site 399741005168 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 399741005169 active site clefts [active] 399741005170 zinc binding site [ion binding]; other site 399741005171 dimer interface [polypeptide binding]; other site 399741005172 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 399741005173 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741005174 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 399741005175 dimerization interface [polypeptide binding]; other site 399741005176 WYL domain; Region: WYL; cl14852 399741005177 TPR repeat; Region: TPR_11; pfam13414 399741005178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 399741005179 TPR motif; other site 399741005180 binding surface 399741005181 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741005182 non-specific DNA binding site [nucleotide binding]; other site 399741005183 salt bridge; other site 399741005184 sequence-specific DNA binding site [nucleotide binding]; other site 399741005185 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 399741005186 hypothetical protein; Region: PHA02067 399741005187 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 399741005188 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 399741005189 catalytic residues [active] 399741005190 catalytic nucleophile [active] 399741005191 Presynaptic Site I dimer interface [polypeptide binding]; other site 399741005192 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 399741005193 Synaptic Flat tetramer interface [polypeptide binding]; other site 399741005194 Synaptic Site I dimer interface [polypeptide binding]; other site 399741005195 DNA binding site [nucleotide binding] 399741005196 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 399741005197 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 399741005198 catalytic residues [active] 399741005199 catalytic nucleophile [active] 399741005200 Recombinase; Region: Recombinase; pfam07508 399741005201 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 399741005202 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 399741005203 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 399741005204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741005205 Walker A/P-loop; other site 399741005206 ATP binding site [chemical binding]; other site 399741005207 ABC transporter signature motif; other site 399741005208 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 399741005209 Walker B; other site 399741005210 ABC transporter; Region: ABC_tran_2; pfam12848 399741005211 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 399741005212 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 399741005213 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 399741005214 ATP binding site [chemical binding]; other site 399741005215 substrate interface [chemical binding]; other site 399741005216 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 399741005217 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 399741005218 dimer interface [polypeptide binding]; other site 399741005219 putative functional site; other site 399741005220 putative MPT binding site; other site 399741005221 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 399741005222 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 399741005223 catalytic nucleophile [active] 399741005224 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 399741005225 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741005226 Walker A/P-loop; other site 399741005227 ATP binding site [chemical binding]; other site 399741005228 Q-loop/lid; other site 399741005229 ABC transporter signature motif; other site 399741005230 Walker B; other site 399741005231 D-loop; other site 399741005232 H-loop/switch region; other site 399741005233 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 399741005234 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741005235 Walker A/P-loop; other site 399741005236 ATP binding site [chemical binding]; other site 399741005237 Q-loop/lid; other site 399741005238 ABC transporter signature motif; other site 399741005239 Walker B; other site 399741005240 D-loop; other site 399741005241 H-loop/switch region; other site 399741005242 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 399741005243 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 399741005244 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 399741005245 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 399741005246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741005247 dimer interface [polypeptide binding]; other site 399741005248 conserved gate region; other site 399741005249 putative PBP binding loops; other site 399741005250 ABC-ATPase subunit interface; other site 399741005251 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 399741005252 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 399741005253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741005254 dimer interface [polypeptide binding]; other site 399741005255 conserved gate region; other site 399741005256 putative PBP binding loops; other site 399741005257 ABC-ATPase subunit interface; other site 399741005258 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 399741005259 CcdB protein; Region: CcdB; pfam01845 399741005260 S-formylglutathione hydrolase; Region: PLN02442 399741005261 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 399741005262 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 399741005263 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 399741005264 substrate binding site [chemical binding]; other site 399741005265 catalytic Zn binding site [ion binding]; other site 399741005266 NAD binding site [chemical binding]; other site 399741005267 structural Zn binding site [ion binding]; other site 399741005268 dimer interface [polypeptide binding]; other site 399741005269 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741005270 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741005271 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 399741005272 putative dimerization interface [polypeptide binding]; other site 399741005273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741005274 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741005275 putative substrate translocation pore; other site 399741005276 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 399741005277 active site 399741005278 Predicted membrane protein [Function unknown]; Region: COG2311 399741005279 hypothetical protein; Provisional; Region: PRK10835 399741005280 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 399741005281 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741005282 DNA binding site [nucleotide binding] 399741005283 domain linker motif; other site 399741005284 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 399741005285 dimerization interface (closed form) [polypeptide binding]; other site 399741005286 ligand binding site [chemical binding]; other site 399741005287 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 399741005288 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 399741005289 ligand binding site [chemical binding]; other site 399741005290 calcium binding site [ion binding]; other site 399741005291 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 399741005292 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 399741005293 Walker A/P-loop; other site 399741005294 ATP binding site [chemical binding]; other site 399741005295 Q-loop/lid; other site 399741005296 ABC transporter signature motif; other site 399741005297 Walker B; other site 399741005298 D-loop; other site 399741005299 H-loop/switch region; other site 399741005300 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 399741005301 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 399741005302 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 399741005303 TM-ABC transporter signature motif; other site 399741005304 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 399741005305 putative active site [active] 399741005306 malate dehydrogenase; Provisional; Region: PRK13529 399741005307 Malic enzyme, N-terminal domain; Region: malic; pfam00390 399741005308 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 399741005309 NAD(P) binding site [chemical binding]; other site 399741005310 cytidine deaminase; Provisional; Region: PRK09027 399741005311 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 399741005312 active site 399741005313 catalytic motif [active] 399741005314 Zn binding site [ion binding]; other site 399741005315 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 399741005316 active site 399741005317 catalytic motif [active] 399741005318 Zn binding site [ion binding]; other site 399741005319 hypothetical protein; Provisional; Region: PRK10711 399741005320 hypothetical protein; Provisional; Region: PRK01821 399741005321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741005322 putative transporter; Provisional; Region: PRK10054 399741005323 putative substrate translocation pore; other site 399741005324 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 399741005325 putative active site [active] 399741005326 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 399741005327 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 399741005328 active site 399741005329 HIGH motif; other site 399741005330 KMSKS motif; other site 399741005331 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 399741005332 tRNA binding surface [nucleotide binding]; other site 399741005333 anticodon binding site; other site 399741005334 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 399741005335 dimer interface [polypeptide binding]; other site 399741005336 putative tRNA-binding site [nucleotide binding]; other site 399741005337 antiporter inner membrane protein; Provisional; Region: PRK11670 399741005338 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 399741005339 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 399741005340 active site 399741005341 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 399741005342 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 399741005343 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 399741005344 ATP-binding site [chemical binding]; other site 399741005345 Sugar specificity; other site 399741005346 Pyrimidine base specificity; other site 399741005347 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 399741005348 trimer interface [polypeptide binding]; other site 399741005349 active site 399741005350 putative assembly protein; Provisional; Region: PRK10833 399741005351 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 399741005352 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 399741005353 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 399741005354 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 399741005355 FOG: CBS domain [General function prediction only]; Region: COG0517 399741005356 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 399741005357 Transporter associated domain; Region: CorC_HlyC; smart01091 399741005358 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 399741005359 active site 399741005360 tetramer interface; other site 399741005361 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 399741005362 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 399741005363 active site 399741005364 tetramer interface; other site 399741005365 polysaccharide export protein Wza; Provisional; Region: PRK15078 399741005366 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 399741005367 SLBB domain; Region: SLBB; pfam10531 399741005368 Low molecular weight phosphatase family; Region: LMWPc; cd00115 399741005369 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 399741005370 active site 399741005371 tyrosine kinase; Provisional; Region: PRK11519 399741005372 Chain length determinant protein; Region: Wzz; pfam02706 399741005373 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 399741005374 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 399741005375 Nucleotide binding site [chemical binding]; other site 399741005376 DTAP/Switch II; other site 399741005377 Switch I; other site 399741005378 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 399741005379 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 399741005380 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 399741005381 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 399741005382 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 399741005383 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 399741005384 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 399741005385 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 399741005386 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 399741005387 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 399741005388 putative ADP-binding pocket [chemical binding]; other site 399741005389 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 399741005390 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 399741005391 Bacterial sugar transferase; Region: Bac_transf; pfam02397 399741005392 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 399741005393 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 399741005394 Walker A/P-loop; other site 399741005395 ATP binding site [chemical binding]; other site 399741005396 Q-loop/lid; other site 399741005397 ABC transporter signature motif; other site 399741005398 Walker B; other site 399741005399 D-loop; other site 399741005400 H-loop/switch region; other site 399741005401 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 399741005402 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 399741005403 HlyD family secretion protein; Region: HlyD_3; pfam13437 399741005404 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 399741005405 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 399741005406 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 399741005407 Substrate binding site; other site 399741005408 Cupin domain; Region: Cupin_2; cl17218 399741005409 phosphomannomutase CpsG; Provisional; Region: PRK15414 399741005410 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 399741005411 active site 399741005412 substrate binding site [chemical binding]; other site 399741005413 metal binding site [ion binding]; metal-binding site 399741005414 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 399741005415 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 399741005416 NAD binding site [chemical binding]; other site 399741005417 homodimer interface [polypeptide binding]; other site 399741005418 active site 399741005419 substrate binding site [chemical binding]; other site 399741005420 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 399741005421 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 399741005422 Mg++ binding site [ion binding]; other site 399741005423 putative catalytic motif [active] 399741005424 substrate binding site [chemical binding]; other site 399741005425 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 399741005426 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 399741005427 putative ADP-binding pocket [chemical binding]; other site 399741005428 This family is most closely related to the GT1 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor...; Region: GT1_WbdM_like; cd04951 399741005429 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 399741005430 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 399741005431 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 399741005432 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 399741005433 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 399741005434 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 399741005435 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 399741005436 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 399741005437 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 399741005438 metal binding site [ion binding]; metal-binding site 399741005439 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 399741005440 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 399741005441 substrate binding site [chemical binding]; other site 399741005442 glutamase interaction surface [polypeptide binding]; other site 399741005443 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 399741005444 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 399741005445 catalytic residues [active] 399741005446 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 399741005447 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 399741005448 putative active site [active] 399741005449 oxyanion strand; other site 399741005450 catalytic triad [active] 399741005451 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 399741005452 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741005453 active site 399741005454 motif I; other site 399741005455 motif II; other site 399741005456 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 399741005457 putative active site pocket [active] 399741005458 4-fold oligomerization interface [polypeptide binding]; other site 399741005459 metal binding residues [ion binding]; metal-binding site 399741005460 3-fold/trimer interface [polypeptide binding]; other site 399741005461 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 399741005462 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741005463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741005464 homodimer interface [polypeptide binding]; other site 399741005465 catalytic residue [active] 399741005466 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 399741005467 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 399741005468 NAD binding site [chemical binding]; other site 399741005469 dimerization interface [polypeptide binding]; other site 399741005470 product binding site; other site 399741005471 substrate binding site [chemical binding]; other site 399741005472 zinc binding site [ion binding]; other site 399741005473 catalytic residues [active] 399741005474 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 399741005475 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 399741005476 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 399741005477 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 399741005478 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 399741005479 putative NAD(P) binding site [chemical binding]; other site 399741005480 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741005481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741005482 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 399741005483 dimerization interface [polypeptide binding]; other site 399741005484 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 399741005485 agmatinase; Region: agmatinase; TIGR01230 399741005486 oligomer interface [polypeptide binding]; other site 399741005487 putative active site [active] 399741005488 Mn binding site [ion binding]; other site 399741005489 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 399741005490 Na binding site [ion binding]; other site 399741005491 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 399741005492 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 399741005493 oligomer interface [polypeptide binding]; other site 399741005494 metal binding site [ion binding]; metal-binding site 399741005495 metal binding site [ion binding]; metal-binding site 399741005496 putative Cl binding site [ion binding]; other site 399741005497 basic sphincter; other site 399741005498 hydrophobic gate; other site 399741005499 periplasmic entrance; other site 399741005500 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741005501 Coenzyme A binding pocket [chemical binding]; other site 399741005502 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 399741005503 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 399741005504 putative C-terminal domain interface [polypeptide binding]; other site 399741005505 putative GSH binding site (G-site) [chemical binding]; other site 399741005506 putative dimer interface [polypeptide binding]; other site 399741005507 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 399741005508 putative N-terminal domain interface [polypeptide binding]; other site 399741005509 putative dimer interface [polypeptide binding]; other site 399741005510 putative substrate binding pocket (H-site) [chemical binding]; other site 399741005511 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 399741005512 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 399741005513 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 399741005514 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 399741005515 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 399741005516 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 399741005517 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 399741005518 homodimer interface [polypeptide binding]; other site 399741005519 substrate-cofactor binding pocket; other site 399741005520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741005521 catalytic residue [active] 399741005522 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 399741005523 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 399741005524 dimer interface [polypeptide binding]; other site 399741005525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741005526 catalytic residue [active] 399741005527 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 399741005528 FOG: CBS domain [General function prediction only]; Region: COG0517 399741005529 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 399741005530 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 399741005531 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 399741005532 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 399741005533 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 399741005534 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 399741005535 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 399741005536 serine transporter; Region: stp; TIGR00814 399741005537 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 399741005538 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 399741005539 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 399741005540 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 399741005541 intersubunit interface [polypeptide binding]; other site 399741005542 active site 399741005543 catalytic residue [active] 399741005544 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 399741005545 active site 399741005546 catalytic residues [active] 399741005547 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 399741005548 active site 399741005549 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 399741005550 active site 399741005551 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 399741005552 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 399741005553 secondary substrate binding site; other site 399741005554 primary substrate binding site; other site 399741005555 inhibition loop; other site 399741005556 dimerization interface [polypeptide binding]; other site 399741005557 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 399741005558 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 399741005559 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 399741005560 catalytic residue [active] 399741005561 putative transporter; Provisional; Region: PRK04972 399741005562 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 399741005563 TrkA-C domain; Region: TrkA_C; pfam02080 399741005564 TrkA-C domain; Region: TrkA_C; pfam02080 399741005565 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 399741005566 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 399741005567 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 399741005568 GSH binding site [chemical binding]; other site 399741005569 catalytic residues [active] 399741005570 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 399741005571 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 399741005572 RimK-like ATP-grasp domain; Region: RimK; pfam08443 399741005573 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 399741005574 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 399741005575 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 399741005576 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 399741005577 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 399741005578 Walker A/P-loop; other site 399741005579 ATP binding site [chemical binding]; other site 399741005580 Q-loop/lid; other site 399741005581 ABC transporter signature motif; other site 399741005582 Walker B; other site 399741005583 D-loop; other site 399741005584 H-loop/switch region; other site 399741005585 TOBE domain; Region: TOBE_2; pfam08402 399741005586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741005587 dimer interface [polypeptide binding]; other site 399741005588 conserved gate region; other site 399741005589 putative PBP binding loops; other site 399741005590 ABC-ATPase subunit interface; other site 399741005591 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 399741005592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741005593 dimer interface [polypeptide binding]; other site 399741005594 conserved gate region; other site 399741005595 putative PBP binding loops; other site 399741005596 ABC-ATPase subunit interface; other site 399741005597 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 399741005598 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 399741005599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741005600 S-adenosylmethionine binding site [chemical binding]; other site 399741005601 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 399741005602 RelB antitoxin; Region: RelB; cl01171 399741005603 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 399741005604 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741005605 substrate binding pocket [chemical binding]; other site 399741005606 membrane-bound complex binding site; other site 399741005607 hinge residues; other site 399741005608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741005609 dimer interface [polypeptide binding]; other site 399741005610 conserved gate region; other site 399741005611 putative PBP binding loops; other site 399741005612 ABC-ATPase subunit interface; other site 399741005613 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 399741005614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741005615 dimer interface [polypeptide binding]; other site 399741005616 conserved gate region; other site 399741005617 putative PBP binding loops; other site 399741005618 ABC-ATPase subunit interface; other site 399741005619 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 399741005620 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741005621 substrate binding pocket [chemical binding]; other site 399741005622 membrane-bound complex binding site; other site 399741005623 hinge residues; other site 399741005624 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 399741005625 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741005626 Walker A/P-loop; other site 399741005627 ATP binding site [chemical binding]; other site 399741005628 Q-loop/lid; other site 399741005629 ABC transporter signature motif; other site 399741005630 Walker B; other site 399741005631 D-loop; other site 399741005632 H-loop/switch region; other site 399741005633 putative lipoprotein; Provisional; Region: PRK10533 399741005634 hypothetical protein; Provisional; Region: PRK02877 399741005635 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 399741005636 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 399741005637 amidase catalytic site [active] 399741005638 Zn binding residues [ion binding]; other site 399741005639 substrate binding site [chemical binding]; other site 399741005640 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 399741005641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 399741005642 NAD(P) binding site [chemical binding]; other site 399741005643 active site 399741005644 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 399741005645 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 399741005646 putative NAD(P) binding site [chemical binding]; other site 399741005647 putative active site [active] 399741005648 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 399741005649 Predicted membrane protein [Function unknown]; Region: COG3326 399741005650 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 399741005651 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 399741005652 tetramer interface [polypeptide binding]; other site 399741005653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741005654 catalytic residue [active] 399741005655 pyruvate dehydrogenase; Provisional; Region: PRK09124 399741005656 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 399741005657 PYR/PP interface [polypeptide binding]; other site 399741005658 dimer interface [polypeptide binding]; other site 399741005659 tetramer interface [polypeptide binding]; other site 399741005660 TPP binding site [chemical binding]; other site 399741005661 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 399741005662 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 399741005663 TPP-binding site [chemical binding]; other site 399741005664 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 399741005665 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 399741005666 FAD binding pocket [chemical binding]; other site 399741005667 FAD binding motif [chemical binding]; other site 399741005668 phosphate binding motif [ion binding]; other site 399741005669 beta-alpha-beta structure motif; other site 399741005670 NAD binding pocket [chemical binding]; other site 399741005671 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 399741005672 catalytic loop [active] 399741005673 iron binding site [ion binding]; other site 399741005674 hybrid cluster protein; Provisional; Region: PRK05290 399741005675 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 399741005676 ACS interaction site; other site 399741005677 CODH interaction site; other site 399741005678 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 399741005679 hybrid metal cluster; other site 399741005680 Predicted membrane protein [Function unknown]; Region: COG2431 399741005681 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 399741005682 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 399741005683 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 399741005684 putative active site [active] 399741005685 putative metal-binding site [ion binding]; other site 399741005686 Protein of unknown function (DUF535); Region: DUF535; pfam04393 399741005687 macrolide transporter subunit MacA; Provisional; Region: PRK11578 399741005688 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 399741005689 HlyD family secretion protein; Region: HlyD_3; pfam13437 399741005690 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 399741005691 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 399741005692 Walker A/P-loop; other site 399741005693 ATP binding site [chemical binding]; other site 399741005694 Q-loop/lid; other site 399741005695 ABC transporter signature motif; other site 399741005696 Walker B; other site 399741005697 D-loop; other site 399741005698 H-loop/switch region; other site 399741005699 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 399741005700 FtsX-like permease family; Region: FtsX; pfam02687 399741005701 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 399741005702 DNA-binding site [nucleotide binding]; DNA binding site 399741005703 RNA-binding motif; other site 399741005704 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 399741005705 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 399741005706 Clp amino terminal domain; Region: Clp_N; pfam02861 399741005707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741005708 Walker A motif; other site 399741005709 ATP binding site [chemical binding]; other site 399741005710 Walker B motif; other site 399741005711 arginine finger; other site 399741005712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741005713 Walker A motif; other site 399741005714 ATP binding site [chemical binding]; other site 399741005715 Walker B motif; other site 399741005716 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 399741005717 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 399741005718 rRNA binding site [nucleotide binding]; other site 399741005719 predicted 30S ribosome binding site; other site 399741005720 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 399741005721 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 399741005722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741005723 Walker A/P-loop; other site 399741005724 ATP binding site [chemical binding]; other site 399741005725 Q-loop/lid; other site 399741005726 ABC transporter signature motif; other site 399741005727 Walker B; other site 399741005728 D-loop; other site 399741005729 H-loop/switch region; other site 399741005730 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 399741005731 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 399741005732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741005733 Walker A/P-loop; other site 399741005734 ATP binding site [chemical binding]; other site 399741005735 Q-loop/lid; other site 399741005736 ABC transporter signature motif; other site 399741005737 Walker B; other site 399741005738 D-loop; other site 399741005739 H-loop/switch region; other site 399741005740 glutathionine S-transferase; Provisional; Region: PRK10542 399741005741 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 399741005742 C-terminal domain interface [polypeptide binding]; other site 399741005743 GSH binding site (G-site) [chemical binding]; other site 399741005744 dimer interface [polypeptide binding]; other site 399741005745 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 399741005746 dimer interface [polypeptide binding]; other site 399741005747 N-terminal domain interface [polypeptide binding]; other site 399741005748 substrate binding pocket (H-site) [chemical binding]; other site 399741005749 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741005750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741005751 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 399741005752 dimerization interface [polypeptide binding]; other site 399741005753 thioredoxin reductase; Provisional; Region: PRK10262 399741005754 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 399741005755 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 399741005756 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 399741005757 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 399741005758 putative DNA binding site [nucleotide binding]; other site 399741005759 putative Zn2+ binding site [ion binding]; other site 399741005760 AsnC family; Region: AsnC_trans_reg; pfam01037 399741005761 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 399741005762 Protein of unknown function (DUF998); Region: DUF998; pfam06197 399741005763 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 399741005764 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 399741005765 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 399741005766 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 399741005767 recombination factor protein RarA; Reviewed; Region: PRK13342 399741005768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741005769 Walker A motif; other site 399741005770 ATP binding site [chemical binding]; other site 399741005771 Walker B motif; other site 399741005772 arginine finger; other site 399741005773 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 399741005774 seryl-tRNA synthetase; Provisional; Region: PRK05431 399741005775 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 399741005776 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 399741005777 dimer interface [polypeptide binding]; other site 399741005778 active site 399741005779 motif 1; other site 399741005780 motif 2; other site 399741005781 motif 3; other site 399741005782 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 399741005783 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 399741005784 putative [Fe4-S4] binding site [ion binding]; other site 399741005785 putative molybdopterin cofactor binding site [chemical binding]; other site 399741005786 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 399741005787 putative molybdopterin cofactor binding site; other site 399741005788 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 399741005789 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 399741005790 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 399741005791 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 399741005792 Protein of unknown function, DUF606; Region: DUF606; pfam04657 399741005793 Protein of unknown function, DUF606; Region: DUF606; pfam04657 399741005794 Protein of unknown function (DUF4243); Region: DUF4243; pfam14027 399741005795 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 399741005796 nudix motif; other site 399741005797 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 399741005798 active site 399741005799 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 399741005800 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 399741005801 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741005802 motif II; other site 399741005803 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 399741005804 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 399741005805 acyl-activating enzyme (AAE) consensus motif; other site 399741005806 AMP binding site [chemical binding]; other site 399741005807 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 399741005808 NADPH bind site [chemical binding]; other site 399741005809 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 399741005810 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 399741005811 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 399741005812 putative MFS family transporter protein; Provisional; Region: PRK03633 399741005813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741005814 putative substrate translocation pore; other site 399741005815 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 399741005816 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 399741005817 FeS/SAM binding site; other site 399741005818 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 399741005819 Pyruvate formate lyase 1; Region: PFL1; cd01678 399741005820 coenzyme A binding site [chemical binding]; other site 399741005821 active site 399741005822 catalytic residues [active] 399741005823 glycine loop; other site 399741005824 formate transporter; Provisional; Region: PRK10805 399741005825 uncharacterized domain; Region: TIGR00702 399741005826 YcaO-like family; Region: YcaO; pfam02624 399741005827 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 399741005828 homodimer interface [polypeptide binding]; other site 399741005829 active site 399741005830 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 399741005831 homodimer interface [polypeptide binding]; other site 399741005832 substrate-cofactor binding pocket; other site 399741005833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741005834 catalytic residue [active] 399741005835 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 399741005836 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 399741005837 hinge; other site 399741005838 active site 399741005839 cytidylate kinase; Provisional; Region: cmk; PRK00023 399741005840 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 399741005841 CMP-binding site; other site 399741005842 The sites determining sugar specificity; other site 399741005843 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 399741005844 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 399741005845 RNA binding site [nucleotide binding]; other site 399741005846 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 399741005847 RNA binding site [nucleotide binding]; other site 399741005848 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 399741005849 RNA binding site [nucleotide binding]; other site 399741005850 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 399741005851 RNA binding site [nucleotide binding]; other site 399741005852 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 399741005853 RNA binding site [nucleotide binding]; other site 399741005854 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 399741005855 IHF dimer interface [polypeptide binding]; other site 399741005856 IHF - DNA interface [nucleotide binding]; other site 399741005857 ComEC family competence protein; Provisional; Region: PRK11539 399741005858 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 399741005859 Competence protein; Region: Competence; pfam03772 399741005860 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 399741005861 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 399741005862 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 399741005863 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 399741005864 Walker A/P-loop; other site 399741005865 ATP binding site [chemical binding]; other site 399741005866 Q-loop/lid; other site 399741005867 ABC transporter signature motif; other site 399741005868 Walker B; other site 399741005869 D-loop; other site 399741005870 H-loop/switch region; other site 399741005871 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 399741005872 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 399741005873 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 399741005874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 399741005875 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 399741005876 DNA-binding site [nucleotide binding]; DNA binding site 399741005877 RNA-binding motif; other site 399741005878 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 399741005879 DNA-binding site [nucleotide binding]; DNA binding site 399741005880 RNA-binding motif; other site 399741005881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 399741005882 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 399741005883 Trm112p-like protein; Region: Trm112p; cl01066 399741005884 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 399741005885 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 399741005886 Ligand binding site; other site 399741005887 oligomer interface; other site 399741005888 hypothetical protein; Provisional; Region: PRK10593 399741005889 Uncharacterized conserved protein [Function unknown]; Region: COG1434 399741005890 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 399741005891 putative active site [active] 399741005892 Methyltransferase domain; Region: Methyltransf_31; pfam13847 399741005893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741005894 S-adenosylmethionine binding site [chemical binding]; other site 399741005895 condesin subunit F; Provisional; Region: PRK05260 399741005896 condesin subunit E; Provisional; Region: PRK05256 399741005897 cell division protein MukB; Provisional; Region: mukB; PRK04863 399741005898 P-loop containing region of AAA domain; Region: AAA_29; cl17516 399741005899 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 399741005900 murein L,D-transpeptidase; Provisional; Region: PRK10594 399741005901 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 399741005902 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 399741005903 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 399741005904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 399741005905 Peptidase M15; Region: Peptidase_M15_3; cl01194 399741005906 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 399741005907 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 399741005908 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741005909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741005910 homodimer interface [polypeptide binding]; other site 399741005911 catalytic residue [active] 399741005912 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 399741005913 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 399741005914 trimer interface [polypeptide binding]; other site 399741005915 eyelet of channel; other site 399741005916 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 399741005917 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 399741005918 putative dimer interface [polypeptide binding]; other site 399741005919 putative anticodon binding site; other site 399741005920 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 399741005921 homodimer interface [polypeptide binding]; other site 399741005922 motif 1; other site 399741005923 motif 2; other site 399741005924 active site 399741005925 motif 3; other site 399741005926 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 399741005927 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 399741005928 active site 399741005929 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 399741005930 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 399741005931 metal binding site [ion binding]; metal-binding site 399741005932 active site 399741005933 I-site; other site 399741005934 aminopeptidase N; Provisional; Region: pepN; PRK14015 399741005935 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 399741005936 active site 399741005937 Zn binding site [ion binding]; other site 399741005938 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 399741005939 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 399741005940 Walker A/P-loop; other site 399741005941 ATP binding site [chemical binding]; other site 399741005942 Q-loop/lid; other site 399741005943 ABC transporter signature motif; other site 399741005944 Walker B; other site 399741005945 D-loop; other site 399741005946 H-loop/switch region; other site 399741005947 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 399741005948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741005949 dimer interface [polypeptide binding]; other site 399741005950 conserved gate region; other site 399741005951 putative PBP binding loops; other site 399741005952 ABC-ATPase subunit interface; other site 399741005953 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 399741005954 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 399741005955 active site 399741005956 dimer interface [polypeptide binding]; other site 399741005957 non-prolyl cis peptide bond; other site 399741005958 insertion regions; other site 399741005959 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 399741005960 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741005961 substrate binding pocket [chemical binding]; other site 399741005962 membrane-bound complex binding site; other site 399741005963 hinge residues; other site 399741005964 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 399741005965 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 399741005966 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 399741005967 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 399741005968 quinone interaction residues [chemical binding]; other site 399741005969 active site 399741005970 catalytic residues [active] 399741005971 FMN binding site [chemical binding]; other site 399741005972 substrate binding site [chemical binding]; other site 399741005973 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 399741005974 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 399741005975 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 399741005976 MOSC domain; Region: MOSC; pfam03473 399741005977 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 399741005978 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 399741005979 catalytic loop [active] 399741005980 iron binding site [ion binding]; other site 399741005981 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 399741005982 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 399741005983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741005984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741005985 S-adenosylmethionine binding site [chemical binding]; other site 399741005986 ABC transporter ATPase component; Reviewed; Region: PRK11147 399741005987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741005988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741005989 Walker A/P-loop; other site 399741005990 Walker A/P-loop; other site 399741005991 ATP binding site [chemical binding]; other site 399741005992 ATP binding site [chemical binding]; other site 399741005993 Q-loop/lid; other site 399741005994 Q-loop/lid; other site 399741005995 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 399741005996 ABC transporter signature motif; other site 399741005997 Walker B; other site 399741005998 D-loop; other site 399741005999 ABC transporter; Region: ABC_tran_2; pfam12848 399741006000 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 399741006001 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 399741006002 Paraquat-inducible protein A; Region: PqiA; pfam04403 399741006003 Paraquat-inducible protein A; Region: PqiA; pfam04403 399741006004 paraquat-inducible protein B; Provisional; Region: PRK10807 399741006005 mce related protein; Region: MCE; pfam02470 399741006006 mce related protein; Region: MCE; pfam02470 399741006007 mce related protein; Region: MCE; pfam02470 399741006008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 399741006009 Protein of unknown function (DUF330); Region: DUF330; pfam03886 399741006010 Ribosome modulation factor; Region: RMF; pfam04957 399741006011 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 399741006012 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 399741006013 dimer interface [polypeptide binding]; other site 399741006014 active site 399741006015 Predicted transcriptional regulators [Transcription]; Region: COG1733 399741006016 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 399741006017 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 399741006018 active site 2 [active] 399741006019 dimer interface [polypeptide binding]; other site 399741006020 active site 1 [active] 399741006021 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 399741006022 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 399741006023 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 399741006024 outer membrane protein A; Reviewed; Region: PRK10808 399741006025 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 399741006026 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 399741006027 ligand binding site [chemical binding]; other site 399741006028 SOS cell division inhibitor; Provisional; Region: PRK10595 399741006029 TfoX N-terminal domain; Region: TfoX_N; pfam04993 399741006030 TfoX C-terminal domain; Region: TfoX_C; pfam04994 399741006031 TIGR01666 family membrane protein; Region: YCCS 399741006032 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 399741006033 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 399741006034 Predicted membrane protein [Function unknown]; Region: COG3304 399741006035 Domain of unknown function (DUF307); Region: DUF307; pfam03733 399741006036 Domain of unknown function (DUF307); Region: DUF307; pfam03733 399741006037 DNA helicase IV; Provisional; Region: helD; PRK11054 399741006038 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 399741006039 Part of AAA domain; Region: AAA_19; pfam13245 399741006040 Family description; Region: UvrD_C_2; pfam13538 399741006041 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 399741006042 active site 399741006043 dimer interfaces [polypeptide binding]; other site 399741006044 catalytic residues [active] 399741006045 hypothetical protein; Provisional; Region: PRK03641 399741006046 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 399741006047 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 399741006048 heat shock protein HspQ; Provisional; Region: PRK14129 399741006049 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 399741006050 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 399741006051 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 399741006052 putative RNA binding site [nucleotide binding]; other site 399741006053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741006054 S-adenosylmethionine binding site [chemical binding]; other site 399741006055 acylphosphatase; Provisional; Region: PRK14426 399741006056 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 399741006057 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 399741006058 YccA-like proteins; Region: YccA_like; cd10433 399741006059 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 399741006060 Methyltransferase domain; Region: Methyltransf_27; pfam13708 399741006061 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 399741006062 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 399741006063 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 399741006064 MPN+ (JAMM) motif; other site 399741006065 Zinc-binding site [ion binding]; other site 399741006066 Antirestriction protein; Region: Antirestrict; pfam03230 399741006067 O-Antigen ligase; Region: Wzy_C; pfam04932 399741006068 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 399741006069 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 399741006070 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 399741006071 putative active site [active] 399741006072 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 399741006073 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 399741006074 Protein of unknown function (DUF770); Region: DUF770; pfam05591 399741006075 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 399741006076 Protein of unknown function (DUF877); Region: DUF877; pfam05943 399741006077 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 399741006078 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 399741006079 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 399741006080 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 399741006081 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 399741006082 ligand binding site [chemical binding]; other site 399741006083 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 399741006084 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 399741006085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741006086 Walker A motif; other site 399741006087 ATP binding site [chemical binding]; other site 399741006088 Walker B motif; other site 399741006089 arginine finger; other site 399741006090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741006091 Walker A motif; other site 399741006092 ATP binding site [chemical binding]; other site 399741006093 Walker B motif; other site 399741006094 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 399741006095 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 399741006096 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 399741006097 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 399741006098 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 399741006099 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 399741006100 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 399741006101 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 399741006102 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 399741006103 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 399741006104 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 399741006105 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 399741006106 PAAR motif; Region: PAAR_motif; pfam05488 399741006107 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 399741006108 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 399741006109 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 399741006110 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 399741006111 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 399741006112 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 399741006113 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 399741006114 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 399741006115 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 399741006116 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 399741006117 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 399741006118 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 399741006119 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 399741006120 ImpA domain protein; Region: DUF3702; pfam12486 399741006121 BCCT family transporter; Region: BCCT; cl00569 399741006122 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 399741006123 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 399741006124 Cytochrome c; Region: Cytochrom_C; pfam00034 399741006125 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 399741006126 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 399741006127 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 399741006128 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 399741006129 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 399741006130 active site 399741006131 substrate binding site [chemical binding]; other site 399741006132 Mg2+ binding site [ion binding]; other site 399741006133 Cation transport protein; Region: TrkH; cl17365 399741006134 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 399741006135 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 399741006136 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 399741006137 LysE type translocator; Region: LysE; cl00565 399741006138 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 399741006139 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741006140 The C-terminal substrate binding domain of LysR-type transcriptional regulator TrpI, which is involved in control of tryptophan synthesis, contains type 2 periplasmic binding fold; Region: PBP2_TrpI; cd08482 399741006141 putative dimerization interface [polypeptide binding]; other site 399741006142 putative substrate binding pocket [chemical binding]; other site 399741006143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741006144 non-specific DNA binding site [nucleotide binding]; other site 399741006145 salt bridge; other site 399741006146 sequence-specific DNA binding site [nucleotide binding]; other site 399741006147 Cupin domain; Region: Cupin_2; cl17218 399741006148 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 399741006149 EamA-like transporter family; Region: EamA; pfam00892 399741006150 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 399741006151 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 399741006152 pyrimidine utilization protein D; Region: RutD; TIGR03611 399741006153 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 399741006154 homotrimer interaction site [polypeptide binding]; other site 399741006155 putative active site [active] 399741006156 Isochorismatase family; Region: Isochorismatase; pfam00857 399741006157 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 399741006158 catalytic triad [active] 399741006159 conserved cis-peptide bond; other site 399741006160 pyrimidine utilization protein A; Region: RutA; TIGR03612 399741006161 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 399741006162 active site 399741006163 dimer interface [polypeptide binding]; other site 399741006164 non-prolyl cis peptide bond; other site 399741006165 insertion regions; other site 399741006166 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 399741006167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741006168 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 399741006169 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 399741006170 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 399741006171 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 399741006172 Uncharacterized conserved protein [Function unknown]; Region: COG1359 399741006173 enoyl-CoA hydratase; Provisional; Region: PRK08252 399741006174 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 399741006175 substrate binding site [chemical binding]; other site 399741006176 oxyanion hole (OAH) forming residues; other site 399741006177 trimer interface [polypeptide binding]; other site 399741006178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741006179 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741006180 putative substrate translocation pore; other site 399741006181 5-aminolevulinate synthase; Validated; Region: PRK09064 399741006182 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 399741006183 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 399741006184 catalytic residue [active] 399741006185 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 399741006186 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 399741006187 dimer interface [polypeptide binding]; other site 399741006188 active site 399741006189 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 399741006190 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 399741006191 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 399741006192 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 399741006193 Autoinducer binding domain; Region: Autoind_bind; pfam03472 399741006194 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741006195 DNA binding residues [nucleotide binding] 399741006196 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 399741006197 Ligand Binding Site [chemical binding]; other site 399741006198 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 399741006199 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 399741006200 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 399741006201 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 399741006202 dimer interface [polypeptide binding]; other site 399741006203 NADP binding site [chemical binding]; other site 399741006204 catalytic residues [active] 399741006205 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 399741006206 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 399741006207 inhibitor site; inhibition site 399741006208 active site 399741006209 dimer interface [polypeptide binding]; other site 399741006210 catalytic residue [active] 399741006211 PAS fold; Region: PAS_4; pfam08448 399741006212 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 399741006213 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741006214 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 399741006215 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 399741006216 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 399741006217 hydroxyglutarate oxidase; Provisional; Region: PRK11728 399741006218 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 399741006219 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 399741006220 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 399741006221 hypothetical protein; Provisional; Region: PRK10613 399741006222 response regulator; Provisional; Region: PRK09483 399741006223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741006224 active site 399741006225 phosphorylation site [posttranslational modification] 399741006226 intermolecular recognition site; other site 399741006227 dimerization interface [polypeptide binding]; other site 399741006228 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741006229 DNA binding residues [nucleotide binding] 399741006230 dimerization interface [polypeptide binding]; other site 399741006231 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 399741006232 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 399741006233 GIY-YIG motif/motif A; other site 399741006234 active site 399741006235 catalytic site [active] 399741006236 putative DNA binding site [nucleotide binding]; other site 399741006237 metal binding site [ion binding]; metal-binding site 399741006238 UvrB/uvrC motif; Region: UVR; pfam02151 399741006239 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 399741006240 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 399741006241 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741006242 non-specific DNA binding site [nucleotide binding]; other site 399741006243 salt bridge; other site 399741006244 sequence-specific DNA binding site [nucleotide binding]; other site 399741006245 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 399741006246 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 399741006247 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 399741006248 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 399741006249 putative active site [active] 399741006250 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 399741006251 active site 399741006252 P-loop; other site 399741006253 phosphorylation site [posttranslational modification] 399741006254 methionine cluster; other site 399741006255 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 399741006256 active site 399741006257 phosphorylation site [posttranslational modification] 399741006258 metal binding site [ion binding]; metal-binding site 399741006259 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 399741006260 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 399741006261 NAD binding site [chemical binding]; other site 399741006262 sugar binding site [chemical binding]; other site 399741006263 divalent metal binding site [ion binding]; other site 399741006264 tetramer (dimer of dimers) interface [polypeptide binding]; other site 399741006265 dimer interface [polypeptide binding]; other site 399741006266 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 399741006267 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 399741006268 phosphoethanolamine transferase; Provisional; Region: PRK11560 399741006269 Sulfatase; Region: Sulfatase; pfam00884 399741006270 proline/glycine betaine transporter; Provisional; Region: PRK10642 399741006271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741006272 putative substrate translocation pore; other site 399741006273 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cd00890 399741006274 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 399741006275 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 399741006276 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 399741006277 Walker A/P-loop; other site 399741006278 ATP binding site [chemical binding]; other site 399741006279 Q-loop/lid; other site 399741006280 ABC transporter signature motif; other site 399741006281 Walker B; other site 399741006282 D-loop; other site 399741006283 H-loop/switch region; other site 399741006284 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 399741006285 FtsX-like permease family; Region: FtsX; pfam02687 399741006286 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 399741006287 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 399741006288 HlyD family secretion protein; Region: HlyD_3; pfam13437 399741006289 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 399741006290 potassium/proton antiporter; Reviewed; Region: PRK05326 399741006291 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 399741006292 TrkA-C domain; Region: TrkA_C; pfam02080 399741006293 Transporter associated domain; Region: CorC_HlyC; smart01091 399741006294 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 399741006295 Acyltransferase family; Region: Acyl_transf_3; pfam01757 399741006296 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 399741006297 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 399741006298 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 399741006299 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 399741006300 Ligand binding site; other site 399741006301 DXD motif; other site 399741006302 lipoprotein; Provisional; Region: PRK10175 399741006303 secY/secA suppressor protein; Provisional; Region: PRK11467 399741006304 2-isopropylmalate synthase; Validated; Region: PRK03739 399741006305 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 399741006306 active site 399741006307 catalytic residues [active] 399741006308 metal binding site [ion binding]; metal-binding site 399741006309 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 399741006310 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 399741006311 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 399741006312 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741006313 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 399741006314 putative DNA binding site [nucleotide binding]; other site 399741006315 dimerization interface [polypeptide binding]; other site 399741006316 putative Zn2+ binding site [ion binding]; other site 399741006317 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 399741006318 Predicted transporter component [General function prediction only]; Region: COG2391 399741006319 Sulphur transport; Region: Sulf_transp; pfam04143 399741006320 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 399741006321 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 399741006322 active site 399741006323 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 399741006324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741006325 putative substrate translocation pore; other site 399741006326 POT family; Region: PTR2; cl17359 399741006327 drug efflux system protein MdtG; Provisional; Region: PRK09874 399741006328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741006329 putative substrate translocation pore; other site 399741006330 YCII-related domain; Region: YCII; cl00999 399741006331 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 399741006332 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 399741006333 putative acyl-acceptor binding pocket; other site 399741006334 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 399741006335 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 399741006336 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 399741006337 active site residue [active] 399741006338 hypothetical protein; Provisional; Region: PRK03757 399741006339 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 399741006340 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 399741006341 Domain of unknown function DUF20; Region: UPF0118; pfam01594 399741006342 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 399741006343 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741006344 DNA binding residues [nucleotide binding] 399741006345 dimerization interface [polypeptide binding]; other site 399741006346 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 399741006347 hydroxyglutarate oxidase; Provisional; Region: PRK11728 399741006348 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 399741006349 DNA damage-inducible protein I; Provisional; Region: PRK10597 399741006350 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 399741006351 active site 399741006352 substrate binding pocket [chemical binding]; other site 399741006353 dimer interface [polypeptide binding]; other site 399741006354 Uncharacterized conserved protein [Function unknown]; Region: COG1359 399741006355 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 399741006356 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 399741006357 homodimer interface [polypeptide binding]; other site 399741006358 oligonucleotide binding site [chemical binding]; other site 399741006359 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 399741006360 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 399741006361 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 399741006362 RNA binding surface [nucleotide binding]; other site 399741006363 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 399741006364 active site 399741006365 Maf-like protein; Region: Maf; pfam02545 399741006366 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 399741006367 active site 399741006368 dimer interface [polypeptide binding]; other site 399741006369 hypothetical protein; Provisional; Region: PRK11193 399741006370 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 399741006371 putative phosphate acyltransferase; Provisional; Region: PRK05331 399741006372 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 399741006373 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 399741006374 dimer interface [polypeptide binding]; other site 399741006375 active site 399741006376 CoA binding pocket [chemical binding]; other site 399741006377 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 399741006378 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 399741006379 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 399741006380 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 399741006381 NAD(P) binding site [chemical binding]; other site 399741006382 homotetramer interface [polypeptide binding]; other site 399741006383 homodimer interface [polypeptide binding]; other site 399741006384 active site 399741006385 acyl carrier protein; Provisional; Region: acpP; PRK00982 399741006386 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 399741006387 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 399741006388 dimer interface [polypeptide binding]; other site 399741006389 active site 399741006390 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 399741006391 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 399741006392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741006393 catalytic residue [active] 399741006394 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 399741006395 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 399741006396 dimerization interface [polypeptide binding]; other site 399741006397 thymidylate kinase; Validated; Region: tmk; PRK00698 399741006398 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 399741006399 TMP-binding site; other site 399741006400 ATP-binding site [chemical binding]; other site 399741006401 DNA polymerase III subunit delta'; Validated; Region: PRK07993 399741006402 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 399741006403 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 399741006404 active site 399741006405 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 399741006406 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 399741006407 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 399741006408 active site turn [active] 399741006409 phosphorylation site [posttranslational modification] 399741006410 manganese transport regulator MntR; Provisional; Region: PRK11050 399741006411 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 399741006412 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 399741006413 manganese transport protein MntH; Reviewed; Region: PRK00701 399741006414 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 399741006415 short chain dehydrogenase; Provisional; Region: PRK06500 399741006416 classical (c) SDRs; Region: SDR_c; cd05233 399741006417 NAD(P) binding site [chemical binding]; other site 399741006418 active site 399741006419 Predicted transcriptional regulators [Transcription]; Region: COG1733 399741006420 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 399741006421 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 399741006422 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741006423 substrate binding pocket [chemical binding]; other site 399741006424 membrane-bound complex binding site; other site 399741006425 hinge residues; other site 399741006426 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 399741006427 nucleotide binding site/active site [active] 399741006428 HIT family signature motif; other site 399741006429 catalytic residue [active] 399741006430 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 399741006431 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 399741006432 putative dimer interface [polypeptide binding]; other site 399741006433 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 399741006434 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 399741006435 thiamine kinase; Region: ycfN_thiK; TIGR02721 399741006436 active site 399741006437 substrate binding site [chemical binding]; other site 399741006438 ATP binding site [chemical binding]; other site 399741006439 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 399741006440 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 399741006441 beta-hexosaminidase; Provisional; Region: PRK05337 399741006442 hypothetical protein; Provisional; Region: PRK04940 399741006443 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 399741006444 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 399741006445 hypothetical protein; Provisional; Region: PRK11280 399741006446 Predicted transcriptional regulator [Transcription]; Region: COG1959 399741006447 Transcriptional regulator; Region: Rrf2; pfam02082 399741006448 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 399741006449 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 399741006450 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 399741006451 HlyD family secretion protein; Region: HlyD_3; pfam13437 399741006452 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 399741006453 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 399741006454 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741006455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741006456 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 399741006457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741006458 putative substrate translocation pore; other site 399741006459 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 399741006460 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 399741006461 putative ligand binding site [chemical binding]; other site 399741006462 NAD binding site [chemical binding]; other site 399741006463 dimerization interface [polypeptide binding]; other site 399741006464 catalytic site [active] 399741006465 putative hydrolase; Validated; Region: PRK09248 399741006466 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 399741006467 active site 399741006468 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 399741006469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 399741006470 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 399741006471 putative metal binding site [ion binding]; other site 399741006472 protease 2; Provisional; Region: PRK10115 399741006473 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 399741006474 exodeoxyribonuclease X; Provisional; Region: PRK07983 399741006475 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 399741006476 active site 399741006477 catalytic site [active] 399741006478 substrate binding site [chemical binding]; other site 399741006479 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 399741006480 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 399741006481 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 399741006482 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 399741006483 Ferritin-like domain; Region: Ferritin; pfam00210 399741006484 ferroxidase diiron center [ion binding]; other site 399741006485 CopC domain; Region: CopC; cl01012 399741006486 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 399741006487 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 399741006488 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 399741006489 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 399741006490 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 399741006491 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 399741006492 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 399741006493 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 399741006494 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 399741006495 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 399741006496 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 399741006497 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741006498 salt bridge; other site 399741006499 non-specific DNA binding site [nucleotide binding]; other site 399741006500 sequence-specific DNA binding site [nucleotide binding]; other site 399741006501 LysR family transcriptional regulator; Provisional; Region: PRK14997 399741006502 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741006503 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 399741006504 putative effector binding pocket; other site 399741006505 putative dimerization interface [polypeptide binding]; other site 399741006506 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 399741006507 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 399741006508 catalytic Zn binding site [ion binding]; other site 399741006509 NAD binding site [chemical binding]; other site 399741006510 structural Zn binding site [ion binding]; other site 399741006511 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 399741006512 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 399741006513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741006514 active site 399741006515 phosphorylation site [posttranslational modification] 399741006516 intermolecular recognition site; other site 399741006517 dimerization interface [polypeptide binding]; other site 399741006518 sensory histidine kinase DcuS; Provisional; Region: PRK11086 399741006519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741006520 ATP binding site [chemical binding]; other site 399741006521 Mg2+ binding site [ion binding]; other site 399741006522 G-X-G motif; other site 399741006523 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 399741006524 Class I aldolases; Region: Aldolase_Class_I; cl17187 399741006525 catalytic residue [active] 399741006526 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 399741006527 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 399741006528 putative ligand binding site [chemical binding]; other site 399741006529 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 399741006530 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 399741006531 Walker A/P-loop; other site 399741006532 ATP binding site [chemical binding]; other site 399741006533 Q-loop/lid; other site 399741006534 ABC transporter signature motif; other site 399741006535 Walker B; other site 399741006536 D-loop; other site 399741006537 H-loop/switch region; other site 399741006538 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 399741006539 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 399741006540 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 399741006541 TM-ABC transporter signature motif; other site 399741006542 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 399741006543 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 399741006544 putative ligand binding site [chemical binding]; other site 399741006545 Right handed beta helix region; Region: Beta_helix; pfam13229 399741006546 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 399741006547 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 399741006548 Haem-binding domain; Region: Haem_bd; pfam14376 399741006549 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 399741006550 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 399741006551 Ligand Binding Site [chemical binding]; other site 399741006552 alpha-glucosidase; Provisional; Region: PRK10137 399741006553 Protein of unknown function, DUF608; Region: DUF608; pfam04685 399741006554 Trehalase; Region: Trehalase; cl17346 399741006555 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 399741006556 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741006557 DNA binding site [nucleotide binding] 399741006558 domain linker motif; other site 399741006559 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 399741006560 putative dimerization interface [polypeptide binding]; other site 399741006561 putative ligand binding site [chemical binding]; other site 399741006562 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 399741006563 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 399741006564 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 399741006565 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 399741006566 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 399741006567 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 399741006568 Amino acid permease; Region: AA_permease_2; pfam13520 399741006569 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 399741006570 dimerization interface [polypeptide binding]; other site 399741006571 putative DNA binding site [nucleotide binding]; other site 399741006572 putative Zn2+ binding site [ion binding]; other site 399741006573 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 399741006574 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 399741006575 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 399741006576 oligomer interface [polypeptide binding]; other site 399741006577 active site residues [active] 399741006578 GTP-binding protein YchF; Reviewed; Region: PRK09601 399741006579 YchF GTPase; Region: YchF; cd01900 399741006580 G1 box; other site 399741006581 GTP/Mg2+ binding site [chemical binding]; other site 399741006582 Switch I region; other site 399741006583 G2 box; other site 399741006584 Switch II region; other site 399741006585 G3 box; other site 399741006586 G4 box; other site 399741006587 G5 box; other site 399741006588 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 399741006589 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 399741006590 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 399741006591 Sulfate transporter family; Region: Sulfate_transp; pfam00916 399741006592 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 399741006593 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 399741006594 putative active site [active] 399741006595 catalytic residue [active] 399741006596 hypothetical protein; Provisional; Region: PRK10692 399741006597 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 399741006598 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 399741006599 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 399741006600 active site 399741006601 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 399741006602 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 399741006603 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 399741006604 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 399741006605 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 399741006606 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 399741006607 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 399741006608 tRNA; other site 399741006609 putative tRNA binding site [nucleotide binding]; other site 399741006610 putative NADP binding site [chemical binding]; other site 399741006611 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 399741006612 peptide chain release factor 1; Validated; Region: prfA; PRK00591 399741006613 This domain is found in peptide chain release factors; Region: PCRF; smart00937 399741006614 RF-1 domain; Region: RF-1; pfam00472 399741006615 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 399741006616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741006617 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 399741006618 hypothetical protein; Provisional; Region: PRK10941 399741006619 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 399741006620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 399741006621 binding surface 399741006622 TPR motif; other site 399741006623 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 399741006624 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 399741006625 putative transporter; Provisional; Region: PRK11660 399741006626 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 399741006627 Sulfate transporter family; Region: Sulfate_transp; pfam00916 399741006628 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 399741006629 hypothetical protein; Provisional; Region: PRK02487 399741006630 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 399741006631 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 399741006632 metal binding site [ion binding]; metal-binding site 399741006633 active site 399741006634 I-site; other site 399741006635 transcription-repair coupling factor; Provisional; Region: PRK10689 399741006636 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 399741006637 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 399741006638 ATP binding site [chemical binding]; other site 399741006639 putative Mg++ binding site [ion binding]; other site 399741006640 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 399741006641 nucleotide binding region [chemical binding]; other site 399741006642 ATP-binding site [chemical binding]; other site 399741006643 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 399741006644 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 399741006645 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 399741006646 tetramer interface [polypeptide binding]; other site 399741006647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741006648 catalytic residue [active] 399741006649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 399741006650 YheO-like PAS domain; Region: PAS_6; pfam08348 399741006651 HTH domain; Region: HTH_22; pfam13309 399741006652 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 399741006653 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 399741006654 FtsX-like permease family; Region: FtsX; pfam02687 399741006655 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 399741006656 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 399741006657 Walker A/P-loop; other site 399741006658 ATP binding site [chemical binding]; other site 399741006659 Q-loop/lid; other site 399741006660 ABC transporter signature motif; other site 399741006661 Walker B; other site 399741006662 D-loop; other site 399741006663 H-loop/switch region; other site 399741006664 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 399741006665 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 399741006666 FtsX-like permease family; Region: FtsX; pfam02687 399741006667 fructokinase; Reviewed; Region: PRK09557 399741006668 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 399741006669 nucleotide binding site [chemical binding]; other site 399741006670 NAD-dependent deacetylase; Provisional; Region: PRK00481 399741006671 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 399741006672 NAD+ binding site [chemical binding]; other site 399741006673 substrate binding site [chemical binding]; other site 399741006674 Zn binding site [ion binding]; other site 399741006675 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 399741006676 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 399741006677 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 399741006678 putative active site [active] 399741006679 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 399741006680 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 399741006681 NAD(P) binding site [chemical binding]; other site 399741006682 LDH/MDH dimer interface [polypeptide binding]; other site 399741006683 substrate binding site [chemical binding]; other site 399741006684 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 399741006685 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 399741006686 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 399741006687 active site turn [active] 399741006688 phosphorylation site [posttranslational modification] 399741006689 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 399741006690 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 399741006691 metal binding site [ion binding]; metal-binding site 399741006692 dimer interface [polypeptide binding]; other site 399741006693 putative dehydrogenase; Provisional; Region: PRK10098 399741006694 Uncharacterized conserved protein [Function unknown]; Region: COG2850 399741006695 Cupin domain; Region: Cupin_2; cl17218 399741006696 sensor protein PhoQ; Provisional; Region: PRK10815 399741006697 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 399741006698 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 399741006699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741006700 ATP binding site [chemical binding]; other site 399741006701 Mg2+ binding site [ion binding]; other site 399741006702 G-X-G motif; other site 399741006703 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 399741006704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741006705 active site 399741006706 phosphorylation site [posttranslational modification] 399741006707 intermolecular recognition site; other site 399741006708 dimerization interface [polypeptide binding]; other site 399741006709 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741006710 DNA binding site [nucleotide binding] 399741006711 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 399741006712 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 399741006713 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 399741006714 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 399741006715 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 399741006716 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 399741006717 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 399741006718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741006719 DNA-binding site [nucleotide binding]; DNA binding site 399741006720 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741006721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741006722 homodimer interface [polypeptide binding]; other site 399741006723 catalytic residue [active] 399741006724 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 399741006725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741006726 Coenzyme A binding pocket [chemical binding]; other site 399741006727 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 399741006728 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 399741006729 adenylosuccinate lyase; Provisional; Region: PRK09285 399741006730 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 399741006731 tetramer interface [polypeptide binding]; other site 399741006732 active site 399741006733 putative lysogenization regulator; Reviewed; Region: PRK00218 399741006734 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 399741006735 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 399741006736 Ligand Binding Site [chemical binding]; other site 399741006737 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 399741006738 nudix motif; other site 399741006739 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 399741006740 pseudouridine synthase; Region: TIGR00093 399741006741 probable active site [active] 399741006742 isocitrate dehydrogenase; Validated; Region: PRK07362 399741006743 isocitrate dehydrogenase; Reviewed; Region: PRK07006 399741006744 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 399741006745 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 399741006746 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 399741006747 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 399741006748 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 399741006749 dimer interface [polypeptide binding]; other site 399741006750 active site 399741006751 Int/Topo IB signature motif; other site 399741006752 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 399741006753 Transposase; Region: HTH_Tnp_1; pfam01527 399741006754 putative transposase OrfB; Reviewed; Region: PHA02517 399741006755 HTH-like domain; Region: HTH_21; pfam13276 399741006756 Integrase core domain; Region: rve; pfam00665 399741006757 Integrase core domain; Region: rve_3; pfam13683 399741006758 KorB domain; Region: KorB; pfam08535 399741006759 Predicted transcriptional regulator [Transcription]; Region: COG2932 399741006760 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 399741006761 Catalytic site [active] 399741006762 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 399741006763 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 399741006764 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440 399741006765 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 399741006766 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 399741006767 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 399741006768 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 399741006769 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 399741006770 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 399741006771 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 399741006772 putative DNA binding site [nucleotide binding]; other site 399741006773 putative Zn2+ binding site [ion binding]; other site 399741006774 AsnC family; Region: AsnC_trans_reg; pfam01037 399741006775 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 399741006776 EamA-like transporter family; Region: EamA; pfam00892 399741006777 EamA-like transporter family; Region: EamA; pfam00892 399741006778 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 399741006779 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 399741006780 TolA C-terminal; Region: TolA; pfam06519 399741006781 Domain of unknown function DUF20; Region: UPF0118; pfam01594 399741006782 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 399741006783 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 399741006784 active site 1 [active] 399741006785 dimer interface [polypeptide binding]; other site 399741006786 hexamer interface [polypeptide binding]; other site 399741006787 active site 2 [active] 399741006788 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 399741006789 classical (c) SDRs; Region: SDR_c; cd05233 399741006790 NAD(P) binding site [chemical binding]; other site 399741006791 active site 399741006792 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 399741006793 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741006794 DNA binding site [nucleotide binding] 399741006795 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 399741006796 putative ligand binding site [chemical binding]; other site 399741006797 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 399741006798 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 399741006799 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 399741006800 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 399741006801 Uncharacterized conserved protein [Function unknown]; Region: COG3791 399741006802 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 399741006803 Protein of unknown function; Region: DUF3658; pfam12395 399741006804 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 399741006805 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 399741006806 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 399741006807 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 399741006808 DNA-binding site [nucleotide binding]; DNA binding site 399741006809 RNA-binding motif; other site 399741006810 Isochorismatase family; Region: Isochorismatase; pfam00857 399741006811 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 399741006812 catalytic triad [active] 399741006813 dimer interface [polypeptide binding]; other site 399741006814 conserved cis-peptide bond; other site 399741006815 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 399741006816 classical (c) SDRs; Region: SDR_c; cd05233 399741006817 NAD(P) binding site [chemical binding]; other site 399741006818 active site 399741006819 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 399741006820 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 399741006821 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 399741006822 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 399741006823 NAD(P) binding site [chemical binding]; other site 399741006824 catalytic residues [active] 399741006825 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 399741006826 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741006827 non-specific DNA binding site [nucleotide binding]; other site 399741006828 salt bridge; other site 399741006829 sequence-specific DNA binding site [nucleotide binding]; other site 399741006830 Cupin domain; Region: Cupin_2; pfam07883 399741006831 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 399741006832 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 399741006833 catalytic triad [active] 399741006834 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 399741006835 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 399741006836 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 399741006837 aromatic amino acid exporter; Provisional; Region: PRK11689 399741006838 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 399741006839 chorismate mutase; Provisional; Region: PRK08055 399741006840 Beta-lactamase; Region: Beta-lactamase; pfam00144 399741006841 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 399741006842 N-formylglutamate amidohydrolase; Region: FGase; cl01522 399741006843 imidazolonepropionase; Validated; Region: PRK09356 399741006844 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 399741006845 active site 399741006846 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 399741006847 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741006848 DNA-binding site [nucleotide binding]; DNA binding site 399741006849 UTRA domain; Region: UTRA; pfam07702 399741006850 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 399741006851 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 399741006852 active site 399741006853 HutD; Region: HutD; pfam05962 399741006854 Transcriptional regulators [Transcription]; Region: PurR; COG1609 399741006855 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741006856 DNA binding site [nucleotide binding] 399741006857 domain linker motif; other site 399741006858 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 399741006859 putative dimerization interface [polypeptide binding]; other site 399741006860 putative ligand binding site [chemical binding]; other site 399741006861 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 399741006862 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 399741006863 substrate binding [chemical binding]; other site 399741006864 active site 399741006865 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 399741006866 galactoside permease; Reviewed; Region: lacY; PRK09528 399741006867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741006868 metabolite-proton symporter; Region: 2A0106; TIGR00883 399741006869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741006870 putative substrate translocation pore; other site 399741006871 Cytochrome c; Region: Cytochrom_C; pfam00034 399741006872 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 399741006873 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 399741006874 Cytochrome c; Region: Cytochrom_C; pfam00034 399741006875 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 399741006876 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 399741006877 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 399741006878 Domain of unknown function (DUF336); Region: DUF336; pfam03928 399741006879 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 399741006880 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 399741006881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 399741006882 hypothetical protein; Provisional; Region: PRK09262 399741006883 hypothetical protein; Validated; Region: PRK06201 399741006884 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 399741006885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741006886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741006887 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 399741006888 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741006889 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 399741006890 putative dimerization interface [polypeptide binding]; other site 399741006891 Dehydroquinase class II; Region: DHquinase_II; pfam01220 399741006892 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 399741006893 trimer interface [polypeptide binding]; other site 399741006894 active site 399741006895 dimer interface [polypeptide binding]; other site 399741006896 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 399741006897 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 399741006898 active site 399741006899 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 399741006900 The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950 399741006901 putative active site [active] 399741006902 Fe(II) binding site [ion binding]; other site 399741006903 putative dimer interface [polypeptide binding]; other site 399741006904 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 399741006905 dimer interface [polypeptide binding]; other site 399741006906 tetramer interface [polypeptide binding]; other site 399741006907 benzoate transport; Region: 2A0115; TIGR00895 399741006908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741006909 putative substrate translocation pore; other site 399741006910 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 399741006911 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 399741006912 active site 399741006913 substrate-binding site [chemical binding]; other site 399741006914 metal-binding site [ion binding] 399741006915 ATP binding site [chemical binding]; other site 399741006916 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 399741006917 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 399741006918 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 399741006919 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 399741006920 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 399741006921 Spore Coat Protein U domain; Region: SCPU; pfam05229 399741006922 Uncharacterized secreted protein [Function unknown]; Region: COG5430 399741006923 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 399741006924 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 399741006925 PapC C-terminal domain; Region: PapC_C; pfam13953 399741006926 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 399741006927 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 399741006928 Spore Coat Protein U domain; Region: SCPU; pfam05229 399741006929 Spore Coat Protein U domain; Region: SCPU; pfam05229 399741006930 Spore Coat Protein U domain; Region: SCPU; pfam05229 399741006931 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 399741006932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741006933 S-adenosylmethionine binding site [chemical binding]; other site 399741006934 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 399741006935 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 399741006936 Paraquat-inducible protein A; Region: PqiA; pfam04403 399741006937 Paraquat-inducible protein A; Region: PqiA; pfam04403 399741006938 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 399741006939 GAF domain; Region: GAF_2; pfam13185 399741006940 ProP expression regulator; Provisional; Region: PRK04950 399741006941 ProQ/FINO family; Region: ProQ; pfam04352 399741006942 putative RNA binding sites [nucleotide binding]; other site 399741006943 carboxy-terminal protease; Provisional; Region: PRK11186 399741006944 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 399741006945 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 399741006946 protein binding site [polypeptide binding]; other site 399741006947 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 399741006948 Catalytic dyad [active] 399741006949 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 399741006950 heat shock protein HtpX; Provisional; Region: PRK05457 399741006951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741006952 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741006953 putative substrate translocation pore; other site 399741006954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741006955 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 399741006956 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 399741006957 dimerization interface [polypeptide binding]; other site 399741006958 putative Zn2+ binding site [ion binding]; other site 399741006959 putative DNA binding site [nucleotide binding]; other site 399741006960 Bacterial transcriptional regulator; Region: IclR; pfam01614 399741006961 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 399741006962 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 399741006963 inner membrane protein; Provisional; Region: PRK11648 399741006964 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 399741006965 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741006966 motif II; other site 399741006967 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 399741006968 YniB-like protein; Region: YniB; pfam14002 399741006969 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 399741006970 Phosphotransferase enzyme family; Region: APH; pfam01636 399741006971 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741006972 Coenzyme A binding pocket [chemical binding]; other site 399741006973 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 399741006974 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 399741006975 ABC-ATPase subunit interface; other site 399741006976 dimer interface [polypeptide binding]; other site 399741006977 putative PBP binding regions; other site 399741006978 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 399741006979 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 399741006980 ABC-ATPase subunit interface; other site 399741006981 dimer interface [polypeptide binding]; other site 399741006982 putative PBP binding regions; other site 399741006983 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 399741006984 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 399741006985 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 399741006986 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 399741006987 metal binding site [ion binding]; metal-binding site 399741006988 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 399741006989 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 399741006990 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 399741006991 N-acetyl-D-glucosamine binding site [chemical binding]; other site 399741006992 catalytic residue [active] 399741006993 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 399741006994 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 399741006995 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 399741006996 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 399741006997 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 399741006998 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 399741006999 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 399741007000 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 399741007001 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 399741007002 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 399741007003 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 399741007004 intersubunit interface [polypeptide binding]; other site 399741007005 inner membrane protein; Provisional; Region: PRK10995 399741007006 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 399741007007 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 399741007008 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 399741007009 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 399741007010 active site 399741007011 dimer interface [polypeptide binding]; other site 399741007012 motif 1; other site 399741007013 motif 2; other site 399741007014 motif 3; other site 399741007015 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 399741007016 anticodon binding site; other site 399741007017 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 399741007018 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 399741007019 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 399741007020 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 399741007021 23S rRNA binding site [nucleotide binding]; other site 399741007022 L21 binding site [polypeptide binding]; other site 399741007023 L13 binding site [polypeptide binding]; other site 399741007024 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 399741007025 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 399741007026 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 399741007027 dimer interface [polypeptide binding]; other site 399741007028 motif 1; other site 399741007029 active site 399741007030 motif 2; other site 399741007031 motif 3; other site 399741007032 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 399741007033 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 399741007034 putative tRNA-binding site [nucleotide binding]; other site 399741007035 B3/4 domain; Region: B3_4; pfam03483 399741007036 tRNA synthetase B5 domain; Region: B5; smart00874 399741007037 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 399741007038 dimer interface [polypeptide binding]; other site 399741007039 motif 1; other site 399741007040 motif 3; other site 399741007041 motif 2; other site 399741007042 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 399741007043 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 399741007044 IHF dimer interface [polypeptide binding]; other site 399741007045 IHF - DNA interface [nucleotide binding]; other site 399741007046 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 399741007047 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 399741007048 dimer interface [polypeptide binding]; other site 399741007049 putative PBP binding regions; other site 399741007050 ABC-ATPase subunit interface; other site 399741007051 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 399741007052 catalytic residues [active] 399741007053 dimer interface [polypeptide binding]; other site 399741007054 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 399741007055 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 399741007056 Walker A/P-loop; other site 399741007057 ATP binding site [chemical binding]; other site 399741007058 Q-loop/lid; other site 399741007059 ABC transporter signature motif; other site 399741007060 Walker B; other site 399741007061 D-loop; other site 399741007062 H-loop/switch region; other site 399741007063 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 399741007064 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 399741007065 inhibitor-cofactor binding pocket; inhibition site 399741007066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741007067 catalytic residue [active] 399741007068 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 399741007069 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 399741007070 Ligand binding site; other site 399741007071 Putative Catalytic site; other site 399741007072 DXD motif; other site 399741007073 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 399741007074 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 399741007075 active site 399741007076 substrate binding site [chemical binding]; other site 399741007077 cosubstrate binding site; other site 399741007078 catalytic site [active] 399741007079 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 399741007080 active site 399741007081 hexamer interface [polypeptide binding]; other site 399741007082 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 399741007083 NAD binding site [chemical binding]; other site 399741007084 substrate binding site [chemical binding]; other site 399741007085 active site 399741007086 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 399741007087 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 399741007088 putative active site [active] 399741007089 putative catalytic site [active] 399741007090 putative Zn binding site [ion binding]; other site 399741007091 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 399741007092 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 399741007093 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 399741007094 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 399741007095 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 399741007096 NlpC/P60 family; Region: NLPC_P60; pfam00877 399741007097 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 399741007098 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 399741007099 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 399741007100 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 399741007101 Uncharacterized conserved protein [Function unknown]; Region: COG0397 399741007102 hypothetical protein; Validated; Region: PRK00029 399741007103 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 399741007104 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 399741007105 Walker A/P-loop; other site 399741007106 ATP binding site [chemical binding]; other site 399741007107 Q-loop/lid; other site 399741007108 ABC transporter signature motif; other site 399741007109 Walker B; other site 399741007110 D-loop; other site 399741007111 H-loop/switch region; other site 399741007112 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 399741007113 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 399741007114 ABC-ATPase subunit interface; other site 399741007115 dimer interface [polypeptide binding]; other site 399741007116 putative PBP binding regions; other site 399741007117 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 399741007118 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 399741007119 putative hemin binding site; other site 399741007120 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 399741007121 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 399741007122 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 399741007123 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 399741007124 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 399741007125 N-terminal plug; other site 399741007126 ligand-binding site [chemical binding]; other site 399741007127 Hemin uptake protein hemP; Region: hemP; pfam10636 399741007128 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 399741007129 catalytic residues [active] 399741007130 dimer interface [polypeptide binding]; other site 399741007131 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 399741007132 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 399741007133 PEP synthetase regulatory protein; Provisional; Region: PRK05339 399741007134 phosphoenolpyruvate synthase; Validated; Region: PRK06464 399741007135 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 399741007136 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 399741007137 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 399741007138 putative inner membrane protein; Provisional; Region: PRK10983 399741007139 Domain of unknown function DUF20; Region: UPF0118; pfam01594 399741007140 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 399741007141 FAD binding domain; Region: FAD_binding_4; pfam01565 399741007142 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 399741007143 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 399741007144 CoenzymeA binding site [chemical binding]; other site 399741007145 subunit interaction site [polypeptide binding]; other site 399741007146 PHB binding site; other site 399741007147 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 399741007148 putative ABC transporter; Region: ycf24; CHL00085 399741007149 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 399741007150 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 399741007151 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 399741007152 Walker A/P-loop; other site 399741007153 ATP binding site [chemical binding]; other site 399741007154 Q-loop/lid; other site 399741007155 ABC transporter signature motif; other site 399741007156 Walker B; other site 399741007157 D-loop; other site 399741007158 H-loop/switch region; other site 399741007159 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 399741007160 FeS assembly protein SufD; Region: sufD; TIGR01981 399741007161 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 399741007162 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 399741007163 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 399741007164 catalytic residue [active] 399741007165 cysteine desufuration protein SufE; Provisional; Region: PRK09296 399741007166 L,D-transpeptidase; Provisional; Region: PRK10190 399741007167 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 399741007168 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 399741007169 murein lipoprotein; Provisional; Region: PRK15396 399741007170 pyruvate kinase; Provisional; Region: PRK09206 399741007171 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 399741007172 domain interfaces; other site 399741007173 active site 399741007174 Cupin domain; Region: Cupin_2; cl17218 399741007175 multidrug efflux protein; Reviewed; Region: PRK01766 399741007176 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 399741007177 cation binding site [ion binding]; other site 399741007178 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 399741007179 Lumazine binding domain; Region: Lum_binding; pfam00677 399741007180 Lumazine binding domain; Region: Lum_binding; pfam00677 399741007181 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 399741007182 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 399741007183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741007184 S-adenosylmethionine binding site [chemical binding]; other site 399741007185 putative transporter; Provisional; Region: PRK11043 399741007186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741007187 putative substrate translocation pore; other site 399741007188 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 399741007189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741007190 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741007191 dimerization interface [polypeptide binding]; other site 399741007192 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 399741007193 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741007194 DNA binding site [nucleotide binding] 399741007195 domain linker motif; other site 399741007196 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 399741007197 dimerization interface [polypeptide binding]; other site 399741007198 ligand binding site [chemical binding]; other site 399741007199 superoxide dismutase; Provisional; Region: PRK10543 399741007200 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 399741007201 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 399741007202 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 399741007203 NlpC/P60 family; Region: NLPC_P60; pfam00877 399741007204 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 399741007205 putative GSH binding site [chemical binding]; other site 399741007206 catalytic residues [active] 399741007207 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 399741007208 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 399741007209 dimer interface [polypeptide binding]; other site 399741007210 catalytic site [active] 399741007211 putative active site [active] 399741007212 putative substrate binding site [chemical binding]; other site 399741007213 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 399741007214 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 399741007215 dimer interface [polypeptide binding]; other site 399741007216 active site 399741007217 metal binding site [ion binding]; metal-binding site 399741007218 glutathione binding site [chemical binding]; other site 399741007219 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 399741007220 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 399741007221 active site 399741007222 metal binding site [ion binding]; metal-binding site 399741007223 nudix motif; other site 399741007224 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 399741007225 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 399741007226 FMN binding site [chemical binding]; other site 399741007227 active site 399741007228 substrate binding site [chemical binding]; other site 399741007229 catalytic residue [active] 399741007230 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 399741007231 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741007232 putative metal dependent hydrolase; Provisional; Region: PRK11598 399741007233 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 399741007234 Sulfatase; Region: Sulfatase; pfam00884 399741007235 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 399741007236 NADH(P)-binding; Region: NAD_binding_10; pfam13460 399741007237 NAD binding site [chemical binding]; other site 399741007238 substrate binding site [chemical binding]; other site 399741007239 putative active site [active] 399741007240 transcriptional regulator; Provisional; Region: PRK10632 399741007241 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741007242 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 399741007243 putative effector binding pocket; other site 399741007244 dimerization interface [polypeptide binding]; other site 399741007245 Predicted Fe-S protein [General function prediction only]; Region: COG3313 399741007246 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 399741007247 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 399741007248 active site 399741007249 catalytic tetrad [active] 399741007250 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 399741007251 nucleophilic elbow; other site 399741007252 catalytic triad; other site 399741007253 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 399741007254 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 399741007255 E-class dimer interface [polypeptide binding]; other site 399741007256 P-class dimer interface [polypeptide binding]; other site 399741007257 active site 399741007258 Cu2+ binding site [ion binding]; other site 399741007259 Zn2+ binding site [ion binding]; other site 399741007260 Fusaric acid resistance protein family; Region: FUSC; pfam04632 399741007261 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 399741007262 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 399741007263 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 399741007264 HlyD family secretion protein; Region: HlyD_3; pfam13437 399741007265 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 399741007266 transcriptional regulator SlyA; Provisional; Region: PRK03573 399741007267 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 399741007268 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 399741007269 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 399741007270 lysozyme inhibitor; Provisional; Region: PRK11372 399741007271 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 399741007272 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 399741007273 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 399741007274 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 399741007275 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 399741007276 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 399741007277 active site 399741007278 HIGH motif; other site 399741007279 dimer interface [polypeptide binding]; other site 399741007280 KMSKS motif; other site 399741007281 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 399741007282 RNA binding surface [nucleotide binding]; other site 399741007283 pyridoxamine kinase; Validated; Region: PRK05756 399741007284 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 399741007285 dimer interface [polypeptide binding]; other site 399741007286 pyridoxal binding site [chemical binding]; other site 399741007287 ATP binding site [chemical binding]; other site 399741007288 glutathionine S-transferase; Provisional; Region: PRK10542 399741007289 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 399741007290 C-terminal domain interface [polypeptide binding]; other site 399741007291 GSH binding site (G-site) [chemical binding]; other site 399741007292 dimer interface [polypeptide binding]; other site 399741007293 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 399741007294 dimer interface [polypeptide binding]; other site 399741007295 N-terminal domain interface [polypeptide binding]; other site 399741007296 substrate binding pocket (H-site) [chemical binding]; other site 399741007297 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 399741007298 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 399741007299 dimer interface [polypeptide binding]; other site 399741007300 active site 399741007301 catalytic residue [active] 399741007302 YjbD family (DUF3811); Region: DUF3811; pfam11656 399741007303 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 399741007304 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 399741007305 Zn2+ binding site [ion binding]; other site 399741007306 Mg2+ binding site [ion binding]; other site 399741007307 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 399741007308 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 399741007309 homotrimer interaction site [polypeptide binding]; other site 399741007310 putative active site [active] 399741007311 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 399741007312 Cupin domain; Region: Cupin_2; cl17218 399741007313 MEKHLA domain; Region: MEKHLA; pfam08670 399741007314 benzoate transporter; Region: benE; TIGR00843 399741007315 Benzoate membrane transport protein; Region: BenE; pfam03594 399741007316 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 399741007317 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741007318 non-specific DNA binding site [nucleotide binding]; other site 399741007319 salt bridge; other site 399741007320 sequence-specific DNA binding site [nucleotide binding]; other site 399741007321 Cupin domain; Region: Cupin_2; pfam07883 399741007322 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 399741007323 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 399741007324 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 399741007325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741007326 putative substrate translocation pore; other site 399741007327 POT family; Region: PTR2; pfam00854 399741007328 endonuclease III; Provisional; Region: PRK10702 399741007329 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 399741007330 minor groove reading motif; other site 399741007331 helix-hairpin-helix signature motif; other site 399741007332 substrate binding pocket [chemical binding]; other site 399741007333 active site 399741007334 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 399741007335 electron transport complex RsxE subunit; Provisional; Region: PRK12405 399741007336 electron transport complex protein RnfG; Validated; Region: PRK01908 399741007337 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 399741007338 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 399741007339 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741007340 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 399741007341 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 399741007342 SLBB domain; Region: SLBB; pfam10531 399741007343 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 399741007344 ferredoxin; Provisional; Region: PRK08764 399741007345 Putative Fe-S cluster; Region: FeS; cl17515 399741007346 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 399741007347 electron transport complex protein RsxA; Provisional; Region: PRK05151 399741007348 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 399741007349 L-arabinose isomerase; Provisional; Region: PRK02929 399741007350 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 399741007351 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 399741007352 trimer interface [polypeptide binding]; other site 399741007353 putative substrate binding site [chemical binding]; other site 399741007354 putative metal binding site [ion binding]; other site 399741007355 ribulokinase; Provisional; Region: PRK04123 399741007356 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 399741007357 N- and C-terminal domain interface [polypeptide binding]; other site 399741007358 active site 399741007359 MgATP binding site [chemical binding]; other site 399741007360 catalytic site [active] 399741007361 metal binding site [ion binding]; metal-binding site 399741007362 carbohydrate binding site [chemical binding]; other site 399741007363 homodimer interface [polypeptide binding]; other site 399741007364 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 399741007365 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 399741007366 ligand binding site [chemical binding]; other site 399741007367 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 399741007368 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 399741007369 Walker A/P-loop; other site 399741007370 ATP binding site [chemical binding]; other site 399741007371 Q-loop/lid; other site 399741007372 ABC transporter signature motif; other site 399741007373 Walker B; other site 399741007374 D-loop; other site 399741007375 H-loop/switch region; other site 399741007376 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 399741007377 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 399741007378 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 399741007379 TM-ABC transporter signature motif; other site 399741007380 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 399741007381 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 399741007382 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741007383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741007384 putative oxidoreductase; Provisional; Region: PRK11579 399741007385 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 399741007386 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 399741007387 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 399741007388 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 399741007389 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 399741007390 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 399741007391 active site 399741007392 purine riboside binding site [chemical binding]; other site 399741007393 AAA domain; Region: AAA_17; pfam13207 399741007394 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 399741007395 active site 399741007396 phosphorylation site [posttranslational modification] 399741007397 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 399741007398 intersubunit interface [polypeptide binding]; other site 399741007399 active site 399741007400 zinc binding site [ion binding]; other site 399741007401 Na+ binding site [ion binding]; other site 399741007402 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 399741007403 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 399741007404 active site 399741007405 P-loop; other site 399741007406 phosphorylation site [posttranslational modification] 399741007407 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 399741007408 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 399741007409 active site 399741007410 ADP/pyrophosphate binding site [chemical binding]; other site 399741007411 dimerization interface [polypeptide binding]; other site 399741007412 allosteric effector site; other site 399741007413 fructose-1,6-bisphosphate binding site; other site 399741007414 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 399741007415 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 399741007416 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 399741007417 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 399741007418 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 399741007419 dimer interface [polypeptide binding]; other site 399741007420 ADP-ribose binding site [chemical binding]; other site 399741007421 active site 399741007422 nudix motif; other site 399741007423 metal binding site [ion binding]; metal-binding site 399741007424 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 399741007425 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 399741007426 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741007427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741007428 homodimer interface [polypeptide binding]; other site 399741007429 catalytic residue [active] 399741007430 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 399741007431 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 399741007432 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 399741007433 active site turn [active] 399741007434 phosphorylation site [posttranslational modification] 399741007435 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 399741007436 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 399741007437 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 399741007438 active site 399741007439 DNA binding site [nucleotide binding] 399741007440 Int/Topo IB signature motif; other site 399741007441 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 399741007442 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 399741007443 Transposase; Region: HTH_Tnp_1; pfam01527 399741007444 putative transposase OrfB; Reviewed; Region: PHA02517 399741007445 HTH-like domain; Region: HTH_21; pfam13276 399741007446 Integrase core domain; Region: rve; pfam00665 399741007447 Integrase core domain; Region: rve_3; pfam13683 399741007448 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 399741007449 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 399741007450 active site 399741007451 catalytic triad [active] 399741007452 oxyanion hole [active] 399741007453 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 399741007454 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 399741007455 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741007456 DNA binding site [nucleotide binding] 399741007457 domain linker motif; other site 399741007458 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 399741007459 putative dimerization interface [polypeptide binding]; other site 399741007460 putative ligand binding site [chemical binding]; other site 399741007461 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 399741007462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741007463 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741007464 dimerization interface [polypeptide binding]; other site 399741007465 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 399741007466 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 399741007467 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741007468 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741007469 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 399741007470 putative effector binding pocket; other site 399741007471 putative dimerization interface [polypeptide binding]; other site 399741007472 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 399741007473 Beta-lactamase; Region: Beta-lactamase; pfam00144 399741007474 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 399741007475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 399741007476 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 399741007477 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 399741007478 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 399741007479 fumarate hydratase; Reviewed; Region: fumC; PRK00485 399741007480 Class II fumarases; Region: Fumarase_classII; cd01362 399741007481 active site 399741007482 tetramer interface [polypeptide binding]; other site 399741007483 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 399741007484 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 399741007485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741007486 putative substrate translocation pore; other site 399741007487 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 399741007488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741007489 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 399741007490 dimerization interface [polypeptide binding]; other site 399741007491 substrate binding pocket [chemical binding]; other site 399741007492 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 399741007493 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 399741007494 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 399741007495 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 399741007496 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 399741007497 Cl- selectivity filter; other site 399741007498 Cl- binding residues [ion binding]; other site 399741007499 pore gating glutamate residue; other site 399741007500 dimer interface [polypeptide binding]; other site 399741007501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741007502 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741007503 putative substrate translocation pore; other site 399741007504 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 399741007505 hypothetical protein; Provisional; Region: PRK13659 399741007506 hypothetical protein; Provisional; Region: PRK02237 399741007507 malonic semialdehyde reductase; Provisional; Region: PRK10538 399741007508 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 399741007509 putative NAD(P) binding site [chemical binding]; other site 399741007510 homodimer interface [polypeptide binding]; other site 399741007511 homotetramer interface [polypeptide binding]; other site 399741007512 active site 399741007513 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 399741007514 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 399741007515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741007516 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741007517 putative substrate translocation pore; other site 399741007518 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 399741007519 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741007520 Walker A/P-loop; other site 399741007521 ATP binding site [chemical binding]; other site 399741007522 Q-loop/lid; other site 399741007523 ABC transporter signature motif; other site 399741007524 Walker B; other site 399741007525 D-loop; other site 399741007526 H-loop/switch region; other site 399741007527 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 399741007528 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 399741007529 substrate binding site [chemical binding]; other site 399741007530 ATP binding site [chemical binding]; other site 399741007531 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 399741007532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741007533 dimer interface [polypeptide binding]; other site 399741007534 conserved gate region; other site 399741007535 putative PBP binding loops; other site 399741007536 ABC-ATPase subunit interface; other site 399741007537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741007538 dimer interface [polypeptide binding]; other site 399741007539 conserved gate region; other site 399741007540 putative PBP binding loops; other site 399741007541 ABC-ATPase subunit interface; other site 399741007542 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 399741007543 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 399741007544 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 399741007545 non-specific DNA interactions [nucleotide binding]; other site 399741007546 DNA binding site [nucleotide binding] 399741007547 sequence specific DNA binding site [nucleotide binding]; other site 399741007548 putative cAMP binding site [chemical binding]; other site 399741007549 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 399741007550 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 399741007551 nucleotide binding site [chemical binding]; other site 399741007552 guanine deaminase; Provisional; Region: PRK09228 399741007553 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 399741007554 active site 399741007555 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 399741007556 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 399741007557 catalytic loop [active] 399741007558 iron binding site [ion binding]; other site 399741007559 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 399741007560 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 399741007561 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 399741007562 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 399741007563 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 399741007564 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 399741007565 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 399741007566 XdhC Rossmann domain; Region: XdhC_C; pfam13478 399741007567 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 399741007568 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 399741007569 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 399741007570 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 399741007571 Zn binding site [ion binding]; other site 399741007572 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 399741007573 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 399741007574 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 399741007575 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 399741007576 active site 399741007577 Zn binding site [ion binding]; other site 399741007578 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 399741007579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741007580 putative substrate translocation pore; other site 399741007581 Isochorismatase family; Region: Isochorismatase; pfam00857 399741007582 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 399741007583 catalytic triad [active] 399741007584 substrate binding site [chemical binding]; other site 399741007585 domain interfaces; other site 399741007586 conserved cis-peptide bond; other site 399741007587 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 399741007588 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 399741007589 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 399741007590 catalytic site [active] 399741007591 hypothetical protein; Provisional; Region: PRK06847 399741007592 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 399741007593 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 399741007594 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 399741007595 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 399741007596 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 399741007597 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 399741007598 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 399741007599 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 399741007600 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 399741007601 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 399741007602 Cytochrome c; Region: Cytochrom_C; pfam00034 399741007603 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 399741007604 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 399741007605 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 399741007606 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 399741007607 HlyD family secretion protein; Region: HlyD_3; pfam13437 399741007608 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 399741007609 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 399741007610 putative active site [active] 399741007611 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 399741007612 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 399741007613 Walker A/P-loop; other site 399741007614 ATP binding site [chemical binding]; other site 399741007615 Q-loop/lid; other site 399741007616 ABC transporter signature motif; other site 399741007617 Walker B; other site 399741007618 D-loop; other site 399741007619 H-loop/switch region; other site 399741007620 hypothetical protein; Provisional; Region: PRK07236 399741007621 FAD binding domain; Region: FAD_binding_3; pfam01494 399741007622 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 399741007623 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 399741007624 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 399741007625 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 399741007626 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 399741007627 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 399741007628 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 399741007629 catalytic loop [active] 399741007630 iron binding site [ion binding]; other site 399741007631 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 399741007632 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 399741007633 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 399741007634 Cytochrome c; Region: Cytochrom_C; pfam00034 399741007635 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 399741007636 Cupin; Region: Cupin_1; smart00835 399741007637 Cupin; Region: Cupin_1; smart00835 399741007638 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 399741007639 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 399741007640 active site turn [active] 399741007641 phosphorylation site [posttranslational modification] 399741007642 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 399741007643 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 399741007644 HPr interaction site; other site 399741007645 glycerol kinase (GK) interaction site [polypeptide binding]; other site 399741007646 active site 399741007647 phosphorylation site [posttranslational modification] 399741007648 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 399741007649 beta-galactosidase; Region: BGL; TIGR03356 399741007650 transcriptional antiterminator BglG; Provisional; Region: PRK09772 399741007651 CAT RNA binding domain; Region: CAT_RBD; smart01061 399741007652 PRD domain; Region: PRD; pfam00874 399741007653 PRD domain; Region: PRD; pfam00874 399741007654 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 399741007655 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741007656 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 399741007657 putative dimerization interface [polypeptide binding]; other site 399741007658 putative substrate binding pocket [chemical binding]; other site 399741007659 Chromate transporter; Region: Chromate_transp; pfam02417 399741007660 Chromate transporter; Region: Chromate_transp; pfam02417 399741007661 Protease inhibitor Inh; Region: Inh; pfam02974 399741007662 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 399741007663 putative acetyltransferase YhhY; Provisional; Region: PRK10140 399741007664 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741007665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 399741007666 Coenzyme A binding pocket [chemical binding]; other site 399741007667 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 399741007668 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 399741007669 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 399741007670 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 399741007671 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 399741007672 Cytochrome c; Region: Cytochrom_C; pfam00034 399741007673 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 399741007674 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 399741007675 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 399741007676 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 399741007677 EamA-like transporter family; Region: EamA; pfam00892 399741007678 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 399741007679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741007680 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 399741007681 active site 399741007682 drug efflux system protein MdtG; Provisional; Region: PRK09874 399741007683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741007684 putative substrate translocation pore; other site 399741007685 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 399741007686 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 399741007687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741007688 active site 399741007689 motif I; other site 399741007690 motif II; other site 399741007691 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 399741007692 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 399741007693 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 399741007694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741007695 Coenzyme A binding pocket [chemical binding]; other site 399741007696 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 399741007697 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 399741007698 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 399741007699 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 399741007700 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 399741007701 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 399741007702 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 399741007703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741007704 dimer interface [polypeptide binding]; other site 399741007705 conserved gate region; other site 399741007706 putative PBP binding loops; other site 399741007707 ABC-ATPase subunit interface; other site 399741007708 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 399741007709 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 399741007710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741007711 dimer interface [polypeptide binding]; other site 399741007712 conserved gate region; other site 399741007713 putative PBP binding loops; other site 399741007714 ABC-ATPase subunit interface; other site 399741007715 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 399741007716 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741007717 Walker A/P-loop; other site 399741007718 ATP binding site [chemical binding]; other site 399741007719 Q-loop/lid; other site 399741007720 ABC transporter signature motif; other site 399741007721 Walker B; other site 399741007722 D-loop; other site 399741007723 H-loop/switch region; other site 399741007724 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 399741007725 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 399741007726 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741007727 Walker A/P-loop; other site 399741007728 ATP binding site [chemical binding]; other site 399741007729 Q-loop/lid; other site 399741007730 ABC transporter signature motif; other site 399741007731 Walker B; other site 399741007732 D-loop; other site 399741007733 H-loop/switch region; other site 399741007734 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 399741007735 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 399741007736 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 399741007737 active site 399741007738 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 399741007739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741007740 putative substrate translocation pore; other site 399741007741 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741007742 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741007743 dimerization interface [polypeptide binding]; other site 399741007744 penicillin-binding protein 2; Provisional; Region: PRK10795 399741007745 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 399741007746 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 399741007747 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 399741007748 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 399741007749 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 399741007750 lipoprotein; Provisional; Region: PRK10540 399741007751 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 399741007752 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 399741007753 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 399741007754 Walker A/P-loop; other site 399741007755 ATP binding site [chemical binding]; other site 399741007756 Q-loop/lid; other site 399741007757 ABC transporter signature motif; other site 399741007758 Walker B; other site 399741007759 D-loop; other site 399741007760 H-loop/switch region; other site 399741007761 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 399741007762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741007763 dimer interface [polypeptide binding]; other site 399741007764 conserved gate region; other site 399741007765 putative PBP binding loops; other site 399741007766 ABC-ATPase subunit interface; other site 399741007767 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741007768 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 399741007769 substrate binding pocket [chemical binding]; other site 399741007770 membrane-bound complex binding site; other site 399741007771 hinge residues; other site 399741007772 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 399741007773 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 399741007774 active site 399741007775 non-prolyl cis peptide bond; other site 399741007776 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 399741007777 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 399741007778 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 399741007779 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 399741007780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741007781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741007782 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 399741007783 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 399741007784 Uncharacterized conserved protein [Function unknown]; Region: COG5276 399741007785 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 399741007786 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 399741007787 putative ligand binding site [chemical binding]; other site 399741007788 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 399741007789 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 399741007790 putative active site [active] 399741007791 metal binding site [ion binding]; metal-binding site 399741007792 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 399741007793 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 399741007794 putative NADP binding site [chemical binding]; other site 399741007795 putative substrate binding site [chemical binding]; other site 399741007796 active site 399741007797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 399741007798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741007799 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 399741007800 protein-splicing catalytic site; other site 399741007801 thioester formation/cholesterol transfer; other site 399741007802 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 399741007803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 399741007804 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 399741007805 hypothetical protein; Provisional; Region: PRK05208 399741007806 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 399741007807 active site 399741007808 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 399741007809 MAC/Perforin domain; Region: MACPF; pfam01823 399741007810 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 399741007811 ArsC family; Region: ArsC; pfam03960 399741007812 catalytic residues [active] 399741007813 arsenical pump membrane protein; Provisional; Region: PRK15445 399741007814 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 399741007815 transmembrane helices; other site 399741007816 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 399741007817 dimerization interface [polypeptide binding]; other site 399741007818 putative DNA binding site [nucleotide binding]; other site 399741007819 putative Zn2+ binding site [ion binding]; other site 399741007820 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 399741007821 Bacterial transcriptional regulator; Region: IclR; pfam01614 399741007822 PAS domain; Region: PAS; smart00091 399741007823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741007824 Walker A motif; other site 399741007825 ATP binding site [chemical binding]; other site 399741007826 Walker B motif; other site 399741007827 arginine finger; other site 399741007828 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 399741007829 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 399741007830 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 399741007831 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 399741007832 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 399741007833 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 399741007834 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 399741007835 putative ligand binding site [chemical binding]; other site 399741007836 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 399741007837 Amidinotransferase; Region: Amidinotransf; cl12043 399741007838 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 399741007839 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741007840 substrate binding pocket [chemical binding]; other site 399741007841 membrane-bound complex binding site; other site 399741007842 hinge residues; other site 399741007843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741007844 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 399741007845 dimer interface [polypeptide binding]; other site 399741007846 conserved gate region; other site 399741007847 putative PBP binding loops; other site 399741007848 ABC-ATPase subunit interface; other site 399741007849 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 399741007850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741007851 dimer interface [polypeptide binding]; other site 399741007852 conserved gate region; other site 399741007853 putative PBP binding loops; other site 399741007854 ABC-ATPase subunit interface; other site 399741007855 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 399741007856 dimerization interface [polypeptide binding]; other site 399741007857 putative DNA binding site [nucleotide binding]; other site 399741007858 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 399741007859 putative Zn2+ binding site [ion binding]; other site 399741007860 AsnC family; Region: AsnC_trans_reg; pfam01037 399741007861 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 399741007862 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 399741007863 active site 399741007864 Zn binding site [ion binding]; other site 399741007865 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 399741007866 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 399741007867 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741007868 Walker A/P-loop; other site 399741007869 ATP binding site [chemical binding]; other site 399741007870 Q-loop/lid; other site 399741007871 ABC transporter signature motif; other site 399741007872 Walker B; other site 399741007873 D-loop; other site 399741007874 H-loop/switch region; other site 399741007875 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 399741007876 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 399741007877 NAD binding site [chemical binding]; other site 399741007878 substrate binding site [chemical binding]; other site 399741007879 catalytic Zn binding site [ion binding]; other site 399741007880 tetramer interface [polypeptide binding]; other site 399741007881 structural Zn binding site [ion binding]; other site 399741007882 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 399741007883 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741007884 DNA binding residues [nucleotide binding] 399741007885 dimerization interface [polypeptide binding]; other site 399741007886 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 399741007887 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741007888 DNA binding residues [nucleotide binding] 399741007889 dimerization interface [polypeptide binding]; other site 399741007890 hypothetical protein; Provisional; Region: PRK15301 399741007891 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 399741007892 PapC N-terminal domain; Region: PapC_N; pfam13954 399741007893 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 399741007894 PapC C-terminal domain; Region: PapC_C; pfam13953 399741007895 putative fimbrial chaperone protein; Provisional; Region: PRK09918 399741007896 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 399741007897 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 399741007898 Protein of unknown function (DUF1120); Region: DUF1120; pfam06551 399741007899 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 399741007900 active site 399741007901 DNA binding site [nucleotide binding] 399741007902 Int/Topo IB signature motif; other site 399741007903 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 399741007904 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 399741007905 NAD(P) binding site [chemical binding]; other site 399741007906 catalytic residues [active] 399741007907 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 399741007908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741007909 Walker A motif; other site 399741007910 ATP binding site [chemical binding]; other site 399741007911 Walker B motif; other site 399741007912 arginine finger; other site 399741007913 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 399741007914 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741007915 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 399741007916 substrate binding pocket [chemical binding]; other site 399741007917 membrane-bound complex binding site; other site 399741007918 hinge residues; other site 399741007919 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 399741007920 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 399741007921 metal-binding site [ion binding] 399741007922 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 399741007923 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 399741007924 metal-binding site [ion binding] 399741007925 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 399741007926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741007927 motif II; other site 399741007928 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 399741007929 putative active site [active] 399741007930 heme pocket [chemical binding]; other site 399741007931 PAS fold; Region: PAS_4; pfam08448 399741007932 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 399741007933 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 399741007934 metal binding site [ion binding]; metal-binding site 399741007935 active site 399741007936 I-site; other site 399741007937 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 399741007938 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 399741007939 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 399741007940 Trp docking motif [polypeptide binding]; other site 399741007941 putative active site [active] 399741007942 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 399741007943 TAP-like protein; Region: Abhydrolase_4; pfam08386 399741007944 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741007945 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741007946 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 399741007947 putative substrate binding pocket [chemical binding]; other site 399741007948 putative dimerization interface [polypeptide binding]; other site 399741007949 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 399741007950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741007951 catalytic residue [active] 399741007952 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 399741007953 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 399741007954 inhibitor-cofactor binding pocket; inhibition site 399741007955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741007956 catalytic residue [active] 399741007957 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 399741007958 GAF domain; Region: GAF; pfam01590 399741007959 PAS domain S-box; Region: sensory_box; TIGR00229 399741007960 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 399741007961 putative active site [active] 399741007962 heme pocket [chemical binding]; other site 399741007963 PAS domain S-box; Region: sensory_box; TIGR00229 399741007964 PAS domain; Region: PAS; smart00091 399741007965 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 399741007966 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 399741007967 metal binding site [ion binding]; metal-binding site 399741007968 active site 399741007969 I-site; other site 399741007970 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 399741007971 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 399741007972 Acylphosphatase; Region: Acylphosphatase; pfam00708 399741007973 HypF finger; Region: zf-HYPF; pfam07503 399741007974 HypF finger; Region: zf-HYPF; pfam07503 399741007975 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 399741007976 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 399741007977 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 399741007978 [4Fe-4S] binding site [ion binding]; other site 399741007979 molybdopterin cofactor binding site; other site 399741007980 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 399741007981 molybdopterin cofactor binding site; other site 399741007982 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 399741007983 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 399741007984 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 399741007985 nickel binding site [ion binding]; other site 399741007986 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 399741007987 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 399741007988 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 399741007989 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 399741007990 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 399741007991 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 399741007992 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 399741007993 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 399741007994 NADH dehydrogenase; Region: NADHdh; cl00469 399741007995 hydrogenase 4 subunit B; Validated; Region: PRK06521 399741007996 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 399741007997 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 399741007998 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 399741007999 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 399741008000 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 399741008001 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 399741008002 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 399741008003 HupF/HypC family; Region: HupF_HypC; cl00394 399741008004 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 399741008005 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 399741008006 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 399741008007 dimerization interface [polypeptide binding]; other site 399741008008 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 399741008009 ATP binding site [chemical binding]; other site 399741008010 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 399741008011 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 399741008012 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 399741008013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741008014 Walker A motif; other site 399741008015 ATP binding site [chemical binding]; other site 399741008016 Walker B motif; other site 399741008017 arginine finger; other site 399741008018 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 399741008019 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 399741008020 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 399741008021 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 399741008022 putative active site [active] 399741008023 heme pocket [chemical binding]; other site 399741008024 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 399741008025 putative active site [active] 399741008026 heme pocket [chemical binding]; other site 399741008027 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 399741008028 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741008029 DNA binding residues [nucleotide binding] 399741008030 dimerization interface [polypeptide binding]; other site 399741008031 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 399741008032 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 399741008033 Domain of unknown function (DUF336); Region: DUF336; pfam03928 399741008034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 399741008035 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 399741008036 nudix motif; other site 399741008037 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 399741008038 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 399741008039 permease DsdX; Provisional; Region: PRK09921 399741008040 gluconate transporter; Region: gntP; TIGR00791 399741008041 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 399741008042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741008043 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 399741008044 dimerization interface [polypeptide binding]; other site 399741008045 substrate binding pocket [chemical binding]; other site 399741008046 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 399741008047 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 399741008048 putative ligand binding site [chemical binding]; other site 399741008049 NAD binding site [chemical binding]; other site 399741008050 catalytic site [active] 399741008051 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 399741008052 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 399741008053 N-terminal plug; other site 399741008054 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 399741008055 ligand-binding site [chemical binding]; other site 399741008056 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741008057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741008058 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 399741008059 putative effector binding pocket; other site 399741008060 putative dimerization interface [polypeptide binding]; other site 399741008061 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 399741008062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741008063 putative substrate translocation pore; other site 399741008064 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 399741008065 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 399741008066 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 399741008067 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 399741008068 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 399741008069 gating phenylalanine in ion channel; other site 399741008070 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741008071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741008072 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 399741008073 putative substrate binding pocket [chemical binding]; other site 399741008074 putative dimerization interface [polypeptide binding]; other site 399741008075 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 399741008076 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 399741008077 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 399741008078 FAD binding domain; Region: FAD_binding_4; pfam01565 399741008079 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 399741008080 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 399741008081 NADP binding site [chemical binding]; other site 399741008082 homodimer interface [polypeptide binding]; other site 399741008083 active site 399741008084 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741008085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741008086 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 399741008087 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 399741008088 nucleotide binding site [chemical binding]; other site 399741008089 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 399741008090 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 399741008091 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741008092 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741008093 dimerization interface [polypeptide binding]; other site 399741008094 benzoate transport; Region: 2A0115; TIGR00895 399741008095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741008096 putative substrate translocation pore; other site 399741008097 Formaldehyde-activating enzyme nesessary for methanogenesis [Energy production and conversion]; Region: COG1795 399741008098 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 399741008099 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 399741008100 active site 399741008101 catalytic tetrad [active] 399741008102 succinic semialdehyde dehydrogenase; Region: PLN02278 399741008103 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 399741008104 tetramerization interface [polypeptide binding]; other site 399741008105 NAD(P) binding site [chemical binding]; other site 399741008106 catalytic residues [active] 399741008107 Transcriptional regulators [Transcription]; Region: MarR; COG1846 399741008108 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 399741008109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741008110 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 399741008111 Coenzyme A binding pocket [chemical binding]; other site 399741008112 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 399741008113 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 399741008114 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 399741008115 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 399741008116 NAD(P) binding site [chemical binding]; other site 399741008117 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 399741008118 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 399741008119 acyl-activating enzyme (AAE) consensus motif; other site 399741008120 putative AMP binding site [chemical binding]; other site 399741008121 putative active site [active] 399741008122 putative CoA binding site [chemical binding]; other site 399741008123 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 399741008124 intracellular protease, PfpI family; Region: PfpI; TIGR01382 399741008125 conserved cys residue [active] 399741008126 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 399741008127 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 399741008128 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 399741008129 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 399741008130 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 399741008131 HlyD family secretion protein; Region: HlyD_3; pfam13437 399741008132 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 399741008133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741008134 putative substrate translocation pore; other site 399741008135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741008136 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 399741008137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741008138 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 399741008139 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 399741008140 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 399741008141 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 399741008142 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741008143 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741008144 dimerization interface [polypeptide binding]; other site 399741008145 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 399741008146 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 399741008147 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 399741008148 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 399741008149 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 399741008150 Domain of Unknown Function with PDB structure (DUF3858); Region: DUF3858; pfam12970 399741008151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741008152 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 399741008153 Coenzyme A binding pocket [chemical binding]; other site 399741008154 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 399741008155 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741008156 non-specific DNA binding site [nucleotide binding]; other site 399741008157 salt bridge; other site 399741008158 sequence-specific DNA binding site [nucleotide binding]; other site 399741008159 Cupin domain; Region: Cupin_2; cl17218 399741008160 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 399741008161 EamA-like transporter family; Region: EamA; pfam00892 399741008162 Probable transposase; Region: OrfB_IS605; pfam01385 399741008163 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 399741008164 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 399741008165 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 399741008166 Cytochrome c; Region: Cytochrom_C; pfam00034 399741008167 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 399741008168 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 399741008169 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 399741008170 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 399741008171 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 399741008172 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 399741008173 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 399741008174 catalytic loop [active] 399741008175 iron binding site [ion binding]; other site 399741008176 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 399741008177 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 399741008178 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 399741008179 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 399741008180 catalytic residue [active] 399741008181 serine O-acetyltransferase; Region: cysE; TIGR01172 399741008182 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 399741008183 trimer interface [polypeptide binding]; other site 399741008184 active site 399741008185 substrate binding site [chemical binding]; other site 399741008186 CoA binding site [chemical binding]; other site 399741008187 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 399741008188 active site residue [active] 399741008189 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 399741008190 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 399741008191 putative ligand binding site [chemical binding]; other site 399741008192 NAD binding site [chemical binding]; other site 399741008193 catalytic site [active] 399741008194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741008195 D-galactonate transporter; Region: 2A0114; TIGR00893 399741008196 putative substrate translocation pore; other site 399741008197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741008198 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 399741008199 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 399741008200 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 399741008201 putative active site [active] 399741008202 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 399741008203 beta-galactosidase; Region: BGL; TIGR03356 399741008204 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 399741008205 heterodimer interface [polypeptide binding]; other site 399741008206 multimer interface [polypeptide binding]; other site 399741008207 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 399741008208 active site 399741008209 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 399741008210 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 399741008211 heterodimer interface [polypeptide binding]; other site 399741008212 active site 399741008213 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 399741008214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741008215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741008216 dimerization interface [polypeptide binding]; other site 399741008217 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 399741008218 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 399741008219 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 399741008220 tetramer interface [polypeptide binding]; other site 399741008221 active site 399741008222 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 399741008223 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 399741008224 benzoate transport; Region: 2A0115; TIGR00895 399741008225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741008226 putative substrate translocation pore; other site 399741008227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741008228 Surface antigen; Region: Bac_surface_Ag; pfam01103 399741008229 Protein of unknown function (DUF4056); Region: DUF4056; pfam13265 399741008230 benzoate transport; Region: 2A0115; TIGR00895 399741008231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741008232 putative substrate translocation pore; other site 399741008233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741008234 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 399741008235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741008236 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 399741008237 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 399741008238 Bacterial transcriptional regulator; Region: IclR; pfam01614 399741008239 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 399741008240 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 399741008241 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 399741008242 catalytic residue [active] 399741008243 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 399741008244 dimer interface [polypeptide binding]; other site 399741008245 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 399741008246 MASE1; Region: MASE1; cl17823 399741008247 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 399741008248 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 399741008249 metal binding site [ion binding]; metal-binding site 399741008250 active site 399741008251 I-site; other site 399741008252 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 399741008253 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 399741008254 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 399741008255 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 399741008256 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 399741008257 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 399741008258 Ca binding site [ion binding]; other site 399741008259 active site 399741008260 catalytic site [active] 399741008261 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 399741008262 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 399741008263 Walker A/P-loop; other site 399741008264 ATP binding site [chemical binding]; other site 399741008265 Q-loop/lid; other site 399741008266 ABC transporter signature motif; other site 399741008267 Walker B; other site 399741008268 D-loop; other site 399741008269 H-loop/switch region; other site 399741008270 TOBE domain; Region: TOBE_2; pfam08402 399741008271 alpha-galactosidase; Provisional; Region: PRK15076 399741008272 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 399741008273 NAD(P) binding site [chemical binding]; other site 399741008274 LDH/MDH dimer interface [polypeptide binding]; other site 399741008275 substrate binding site [chemical binding]; other site 399741008276 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 399741008277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741008278 dimer interface [polypeptide binding]; other site 399741008279 conserved gate region; other site 399741008280 putative PBP binding loops; other site 399741008281 ABC-ATPase subunit interface; other site 399741008282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741008283 dimer interface [polypeptide binding]; other site 399741008284 conserved gate region; other site 399741008285 putative PBP binding loops; other site 399741008286 ABC-ATPase subunit interface; other site 399741008287 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 399741008288 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 399741008289 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741008290 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741008291 LysR substrate binding domain; Region: LysR_substrate; pfam03466 399741008292 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 399741008293 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 399741008294 Mechanosensitive ion channel; Region: MS_channel; pfam00924 399741008295 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 399741008296 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 399741008297 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 399741008298 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 399741008299 Cation efflux family; Region: Cation_efflux; cl00316 399741008300 Cation efflux family; Region: Cation_efflux; cl00316 399741008301 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 399741008302 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 399741008303 Divalent cation transporter; Region: MgtE; pfam01769 399741008304 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 399741008305 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 399741008306 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 399741008307 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 399741008308 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 399741008309 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 399741008310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741008311 dimer interface [polypeptide binding]; other site 399741008312 conserved gate region; other site 399741008313 putative PBP binding loops; other site 399741008314 ABC-ATPase subunit interface; other site 399741008315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741008316 dimer interface [polypeptide binding]; other site 399741008317 conserved gate region; other site 399741008318 putative PBP binding loops; other site 399741008319 ABC-ATPase subunit interface; other site 399741008320 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 399741008321 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 399741008322 Walker A/P-loop; other site 399741008323 ATP binding site [chemical binding]; other site 399741008324 Q-loop/lid; other site 399741008325 ABC transporter signature motif; other site 399741008326 Walker B; other site 399741008327 D-loop; other site 399741008328 H-loop/switch region; other site 399741008329 elongation factor G; Reviewed; Region: PRK00007 399741008330 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 399741008331 G1 box; other site 399741008332 putative GEF interaction site [polypeptide binding]; other site 399741008333 GTP/Mg2+ binding site [chemical binding]; other site 399741008334 Switch I region; other site 399741008335 G2 box; other site 399741008336 G3 box; other site 399741008337 Switch II region; other site 399741008338 G4 box; other site 399741008339 G5 box; other site 399741008340 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 399741008341 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 399741008342 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 399741008343 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 399741008344 EamA-like transporter family; Region: EamA; pfam00892 399741008345 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 399741008346 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 399741008347 intersubunit interface [polypeptide binding]; other site 399741008348 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 399741008349 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 399741008350 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741008351 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 399741008352 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 399741008353 tetramerization interface [polypeptide binding]; other site 399741008354 NAD(P) binding site [chemical binding]; other site 399741008355 catalytic residues [active] 399741008356 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 399741008357 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 399741008358 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 399741008359 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 399741008360 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 399741008361 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 399741008362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 399741008363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741008364 Cupin domain; Region: Cupin_2; pfam07883 399741008365 K+ potassium transporter; Region: K_trans; pfam02705 399741008366 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 399741008367 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741008368 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 399741008369 dimerization interface [polypeptide binding]; other site 399741008370 substrate binding pocket [chemical binding]; other site 399741008371 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 399741008372 TM-ABC transporter signature motif; other site 399741008373 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 399741008374 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 399741008375 TM-ABC transporter signature motif; other site 399741008376 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 399741008377 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 399741008378 Walker A/P-loop; other site 399741008379 ATP binding site [chemical binding]; other site 399741008380 Q-loop/lid; other site 399741008381 ABC transporter signature motif; other site 399741008382 Walker B; other site 399741008383 D-loop; other site 399741008384 H-loop/switch region; other site 399741008385 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 399741008386 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 399741008387 Walker A/P-loop; other site 399741008388 ATP binding site [chemical binding]; other site 399741008389 Q-loop/lid; other site 399741008390 ABC transporter signature motif; other site 399741008391 Walker B; other site 399741008392 D-loop; other site 399741008393 H-loop/switch region; other site 399741008394 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 399741008395 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 399741008396 dimerization interface [polypeptide binding]; other site 399741008397 ligand binding site [chemical binding]; other site 399741008398 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 399741008399 allantoate amidohydrolase; Reviewed; Region: PRK09290 399741008400 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 399741008401 active site 399741008402 metal binding site [ion binding]; metal-binding site 399741008403 dimer interface [polypeptide binding]; other site 399741008404 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 399741008405 dimerization interface [polypeptide binding]; other site 399741008406 putative DNA binding site [nucleotide binding]; other site 399741008407 putative Zn2+ binding site [ion binding]; other site 399741008408 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 399741008409 putative hydrophobic ligand binding site [chemical binding]; other site 399741008410 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 399741008411 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 399741008412 Cl binding site [ion binding]; other site 399741008413 oligomer interface [polypeptide binding]; other site 399741008414 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 399741008415 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 399741008416 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 399741008417 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 399741008418 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 399741008419 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 399741008420 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 399741008421 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 399741008422 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 399741008423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741008424 DNA-binding site [nucleotide binding]; DNA binding site 399741008425 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741008426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741008427 homodimer interface [polypeptide binding]; other site 399741008428 catalytic residue [active] 399741008429 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 399741008430 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 399741008431 catalytic triad [active] 399741008432 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 399741008433 dimer interface [polypeptide binding]; other site 399741008434 pyridoxamine kinase; Validated; Region: PRK05756 399741008435 pyridoxal binding site [chemical binding]; other site 399741008436 ATP binding site [chemical binding]; other site 399741008437 Flagellar regulator YcgR; Region: YcgR; pfam07317 399741008438 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 399741008439 PilZ domain; Region: PilZ; pfam07238 399741008440 N-formylglutamate amidohydrolase; Region: FGase; cl01522 399741008441 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 399741008442 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 399741008443 putative acyl-acceptor binding pocket; other site 399741008444 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 399741008445 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 399741008446 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 399741008447 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 399741008448 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 399741008449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 399741008450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741008451 ABC-ATPase subunit interface; other site 399741008452 putative PBP binding loops; other site 399741008453 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 399741008454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741008455 dimer interface [polypeptide binding]; other site 399741008456 conserved gate region; other site 399741008457 putative PBP binding loops; other site 399741008458 ABC-ATPase subunit interface; other site 399741008459 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 399741008460 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 399741008461 Walker A/P-loop; other site 399741008462 ATP binding site [chemical binding]; other site 399741008463 Q-loop/lid; other site 399741008464 ABC transporter signature motif; other site 399741008465 Walker B; other site 399741008466 D-loop; other site 399741008467 H-loop/switch region; other site 399741008468 TOBE domain; Region: TOBE_2; pfam08402 399741008469 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 399741008470 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 399741008471 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 399741008472 fructokinase; Reviewed; Region: PRK09557 399741008473 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 399741008474 nucleotide binding site [chemical binding]; other site 399741008475 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 399741008476 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 399741008477 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 399741008478 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 399741008479 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 399741008480 dimer interface [polypeptide binding]; other site 399741008481 active site 399741008482 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 399741008483 putative active site [active] 399741008484 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 399741008485 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 399741008486 intersubunit interface [polypeptide binding]; other site 399741008487 active site 399741008488 zinc binding site [ion binding]; other site 399741008489 Na+ binding site [ion binding]; other site 399741008490 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 399741008491 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 399741008492 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 399741008493 DNA binding site [nucleotide binding] 399741008494 active site 399741008495 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 399741008496 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 399741008497 ligand binding site [chemical binding]; other site 399741008498 flexible hinge region; other site 399741008499 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 399741008500 putative switch regulator; other site 399741008501 non-specific DNA interactions [nucleotide binding]; other site 399741008502 DNA binding site [nucleotide binding] 399741008503 sequence specific DNA binding site [nucleotide binding]; other site 399741008504 putative cAMP binding site [chemical binding]; other site 399741008505 universal stress protein UspE; Provisional; Region: PRK11175 399741008506 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 399741008507 Ligand Binding Site [chemical binding]; other site 399741008508 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 399741008509 Ligand Binding Site [chemical binding]; other site 399741008510 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 399741008511 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 399741008512 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 399741008513 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 399741008514 ligand binding site [chemical binding]; other site 399741008515 homodimer interface [polypeptide binding]; other site 399741008516 NAD(P) binding site [chemical binding]; other site 399741008517 trimer interface B [polypeptide binding]; other site 399741008518 trimer interface A [polypeptide binding]; other site 399741008519 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 399741008520 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 399741008521 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 399741008522 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 399741008523 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 399741008524 Spore germination protein; Region: Spore_permease; cl17796 399741008525 dihydromonapterin reductase; Provisional; Region: PRK06483 399741008526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 399741008527 NAD(P) binding site [chemical binding]; other site 399741008528 active site 399741008529 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 399741008530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741008531 active site 399741008532 phosphorylation site [posttranslational modification] 399741008533 intermolecular recognition site; other site 399741008534 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741008535 DNA binding site [nucleotide binding] 399741008536 sensor protein RstB; Provisional; Region: PRK10604 399741008537 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 399741008538 dimerization interface [polypeptide binding]; other site 399741008539 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741008540 dimer interface [polypeptide binding]; other site 399741008541 phosphorylation site [posttranslational modification] 399741008542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741008543 ATP binding site [chemical binding]; other site 399741008544 Mg2+ binding site [ion binding]; other site 399741008545 G-X-G motif; other site 399741008546 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 399741008547 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 399741008548 active site 399741008549 Zn binding site [ion binding]; other site 399741008550 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 399741008551 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 399741008552 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 399741008553 ATP binding site [chemical binding]; other site 399741008554 putative Mg++ binding site [ion binding]; other site 399741008555 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 399741008556 nucleotide binding region [chemical binding]; other site 399741008557 ATP-binding site [chemical binding]; other site 399741008558 Helicase associated domain (HA2); Region: HA2; pfam04408 399741008559 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 399741008560 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 399741008561 azoreductase; Reviewed; Region: PRK00170 399741008562 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 399741008563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 399741008564 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 399741008565 hypothetical protein; Provisional; Region: PRK10695 399741008566 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 399741008567 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 399741008568 putative ligand binding site [chemical binding]; other site 399741008569 putative NAD binding site [chemical binding]; other site 399741008570 catalytic site [active] 399741008571 heat-inducible protein; Provisional; Region: PRK10449 399741008572 Domain of unknown function (DUF333); Region: DUF333; pfam03891 399741008573 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 399741008574 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 399741008575 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 399741008576 dimer interface [polypeptide binding]; other site 399741008577 PYR/PP interface [polypeptide binding]; other site 399741008578 TPP binding site [chemical binding]; other site 399741008579 substrate binding site [chemical binding]; other site 399741008580 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 399741008581 Domain of unknown function; Region: EKR; pfam10371 399741008582 4Fe-4S binding domain; Region: Fer4_6; pfam12837 399741008583 4Fe-4S binding domain; Region: Fer4; pfam00037 399741008584 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 399741008585 TPP-binding site [chemical binding]; other site 399741008586 dimer interface [polypeptide binding]; other site 399741008587 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 399741008588 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 399741008589 Catalytic site [active] 399741008590 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 399741008591 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 399741008592 active site 399741008593 DNA binding site [nucleotide binding] 399741008594 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 399741008595 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 399741008596 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 399741008597 Ligand Binding Site [chemical binding]; other site 399741008598 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 399741008599 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 399741008600 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 399741008601 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 399741008602 Cl binding site [ion binding]; other site 399741008603 oligomer interface [polypeptide binding]; other site 399741008604 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 399741008605 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 399741008606 peptide binding site [polypeptide binding]; other site 399741008607 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 399741008608 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 399741008609 putative NAD(P) binding site [chemical binding]; other site 399741008610 murein peptide amidase A; Provisional; Region: PRK10602 399741008611 active site 399741008612 Zn binding site [ion binding]; other site 399741008613 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 399741008614 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 399741008615 active site 399741008616 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 399741008617 dimer interface [polypeptide binding]; other site 399741008618 catalytic triad [active] 399741008619 peroxidatic and resolving cysteines [active] 399741008620 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 399741008621 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 399741008622 putative aromatic amino acid binding site; other site 399741008623 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 399741008624 putative active site [active] 399741008625 heme pocket [chemical binding]; other site 399741008626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741008627 Walker A motif; other site 399741008628 ATP binding site [chemical binding]; other site 399741008629 Walker B motif; other site 399741008630 arginine finger; other site 399741008631 hypothetical protein; Provisional; Region: PRK05415 399741008632 Domain of unknown function (DUF697); Region: DUF697; cl12064 399741008633 Predicted ATPase [General function prediction only]; Region: COG3106 399741008634 Phage shock protein PspD (Phageshock_PspD); Region: Phageshock_PspD; pfam09584 399741008635 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 399741008636 phage shock protein C; Region: phageshock_pspC; TIGR02978 399741008637 phage shock protein B; Provisional; Region: pspB; PRK09458 399741008638 phage shock protein PspA; Provisional; Region: PRK10698 399741008639 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 399741008640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741008641 Walker A motif; other site 399741008642 ATP binding site [chemical binding]; other site 399741008643 Walker B motif; other site 399741008644 arginine finger; other site 399741008645 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 399741008646 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 399741008647 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 399741008648 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 399741008649 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 399741008650 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 399741008651 trimer interface [polypeptide binding]; other site 399741008652 active site 399741008653 putative GTP cyclohydrolase; Provisional; Region: PRK13674 399741008654 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 399741008655 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 399741008656 peptide binding site [polypeptide binding]; other site 399741008657 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 399741008658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741008659 dimer interface [polypeptide binding]; other site 399741008660 conserved gate region; other site 399741008661 putative PBP binding loops; other site 399741008662 ABC-ATPase subunit interface; other site 399741008663 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 399741008664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741008665 dimer interface [polypeptide binding]; other site 399741008666 conserved gate region; other site 399741008667 putative PBP binding loops; other site 399741008668 ABC-ATPase subunit interface; other site 399741008669 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 399741008670 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741008671 Walker A/P-loop; other site 399741008672 ATP binding site [chemical binding]; other site 399741008673 Q-loop/lid; other site 399741008674 ABC transporter signature motif; other site 399741008675 Walker B; other site 399741008676 D-loop; other site 399741008677 H-loop/switch region; other site 399741008678 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 399741008679 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 399741008680 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741008681 Walker A/P-loop; other site 399741008682 ATP binding site [chemical binding]; other site 399741008683 Q-loop/lid; other site 399741008684 ABC transporter signature motif; other site 399741008685 Walker B; other site 399741008686 D-loop; other site 399741008687 H-loop/switch region; other site 399741008688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 399741008689 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 399741008690 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 399741008691 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741008692 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741008693 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 399741008694 dimerization interface [polypeptide binding]; other site 399741008695 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 399741008696 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 399741008697 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 399741008698 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 399741008699 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 399741008700 putative molybdopterin cofactor binding site [chemical binding]; other site 399741008701 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 399741008702 putative molybdopterin cofactor binding site; other site 399741008703 exoribonuclease II; Provisional; Region: PRK05054 399741008704 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 399741008705 RNB domain; Region: RNB; pfam00773 399741008706 S1 RNA binding domain; Region: S1; pfam00575 399741008707 carbon starvation protein A; Provisional; Region: PRK15015 399741008708 Carbon starvation protein CstA; Region: CstA; pfam02554 399741008709 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 399741008710 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 399741008711 active site 399741008712 intersubunit interactions; other site 399741008713 catalytic residue [active] 399741008714 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 399741008715 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 399741008716 FeS/SAM binding site; other site 399741008717 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 399741008718 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 399741008719 dimer interface [polypeptide binding]; other site 399741008720 active site 399741008721 glycine loop; other site 399741008722 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 399741008723 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 399741008724 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 399741008725 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 399741008726 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 399741008727 intersubunit interface [polypeptide binding]; other site 399741008728 active site 399741008729 Zn2+ binding site [ion binding]; other site 399741008730 lipoprotein; Provisional; Region: PRK10540 399741008731 translation initiation factor Sui1; Validated; Region: PRK06824 399741008732 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 399741008733 putative rRNA binding site [nucleotide binding]; other site 399741008734 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 399741008735 active site 399741008736 dimer interface [polypeptide binding]; other site 399741008737 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 399741008738 Arc-like DNA binding domain; Region: Arc; pfam03869 399741008739 tetratricopeptide repeat protein; Provisional; Region: PRK11788 399741008740 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 399741008741 TPR motif; other site 399741008742 binding surface 399741008743 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 399741008744 binding surface 399741008745 TPR motif; other site 399741008746 Predicted membrane protein [Function unknown]; Region: COG3771 399741008747 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 399741008748 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 399741008749 active site 399741008750 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 399741008751 dimerization interface [polypeptide binding]; other site 399741008752 active site 399741008753 aconitate hydratase; Validated; Region: PRK09277 399741008754 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 399741008755 substrate binding site [chemical binding]; other site 399741008756 ligand binding site [chemical binding]; other site 399741008757 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 399741008758 substrate binding site [chemical binding]; other site 399741008759 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 399741008760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741008761 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 399741008762 substrate binding site [chemical binding]; other site 399741008763 putative dimerization interface [polypeptide binding]; other site 399741008764 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 399741008765 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 399741008766 active site 399741008767 interdomain interaction site; other site 399741008768 putative metal-binding site [ion binding]; other site 399741008769 nucleotide binding site [chemical binding]; other site 399741008770 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 399741008771 domain I; other site 399741008772 DNA binding groove [nucleotide binding] 399741008773 phosphate binding site [ion binding]; other site 399741008774 domain II; other site 399741008775 domain III; other site 399741008776 nucleotide binding site [chemical binding]; other site 399741008777 catalytic site [active] 399741008778 domain IV; other site 399741008779 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 399741008780 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 399741008781 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 399741008782 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 399741008783 hypothetical protein; Provisional; Region: PRK11037 399741008784 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 399741008785 putative inner membrane peptidase; Provisional; Region: PRK11778 399741008786 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 399741008787 tandem repeat interface [polypeptide binding]; other site 399741008788 oligomer interface [polypeptide binding]; other site 399741008789 active site residues [active] 399741008790 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 399741008791 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 399741008792 NADP binding site [chemical binding]; other site 399741008793 homodimer interface [polypeptide binding]; other site 399741008794 active site 399741008795 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 399741008796 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 399741008797 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 399741008798 homodimer interface [polypeptide binding]; other site 399741008799 Walker A motif; other site 399741008800 ATP binding site [chemical binding]; other site 399741008801 hydroxycobalamin binding site [chemical binding]; other site 399741008802 Walker B motif; other site 399741008803 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 399741008804 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 399741008805 RNA binding surface [nucleotide binding]; other site 399741008806 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 399741008807 probable active site [active] 399741008808 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 399741008809 hypothetical protein; Provisional; Region: PRK11630 399741008810 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 399741008811 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 399741008812 active site 399741008813 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 399741008814 anthranilate synthase component I; Provisional; Region: PRK13564 399741008815 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 399741008816 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 399741008817 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 399741008818 Glutamine amidotransferase class-I; Region: GATase; pfam00117 399741008819 glutamine binding [chemical binding]; other site 399741008820 catalytic triad [active] 399741008821 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 399741008822 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 399741008823 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 399741008824 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 399741008825 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 399741008826 active site 399741008827 ribulose/triose binding site [chemical binding]; other site 399741008828 phosphate binding site [ion binding]; other site 399741008829 substrate (anthranilate) binding pocket [chemical binding]; other site 399741008830 product (indole) binding pocket [chemical binding]; other site 399741008831 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 399741008832 active site 399741008833 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 399741008834 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 399741008835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741008836 catalytic residue [active] 399741008837 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 399741008838 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 399741008839 substrate binding site [chemical binding]; other site 399741008840 active site 399741008841 catalytic residues [active] 399741008842 heterodimer interface [polypeptide binding]; other site 399741008843 BON domain; Region: BON; pfam04972 399741008844 outer membrane protein W; Provisional; Region: PRK10959 399741008845 hypothetical protein; Provisional; Region: PRK02868 399741008846 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 399741008847 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 399741008848 Sulfate transporter family; Region: Sulfate_transp; pfam00916 399741008849 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 399741008850 intracellular septation protein A; Reviewed; Region: PRK00259 399741008851 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 399741008852 Transcriptional regulators [Transcription]; Region: PurR; COG1609 399741008853 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741008854 DNA binding site [nucleotide binding] 399741008855 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 399741008856 ligand binding site [chemical binding]; other site 399741008857 dimerization interface [polypeptide binding]; other site 399741008858 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 399741008859 active site 399741008860 putative transporter; Provisional; Region: PRK03699 399741008861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741008862 putative substrate translocation pore; other site 399741008863 transport protein TonB; Provisional; Region: PRK10819 399741008864 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 399741008865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 399741008866 YciI-like protein; Reviewed; Region: PRK11370 399741008867 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 399741008868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 399741008869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741008870 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 399741008871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741008872 putative substrate translocation pore; other site 399741008873 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 399741008874 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 399741008875 dimerization interface [polypeptide binding]; other site 399741008876 DPS ferroxidase diiron center [ion binding]; other site 399741008877 ion pore; other site 399741008878 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 399741008879 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 399741008880 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 399741008881 putative active site [active] 399741008882 catalytic site [active] 399741008883 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 399741008884 putative active site [active] 399741008885 catalytic site [active] 399741008886 dsDNA-mimic protein; Reviewed; Region: PRK05094 399741008887 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 399741008888 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 399741008889 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 399741008890 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 399741008891 Proteobacterial glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK_like_proteobact; cd07794 399741008892 N- and C-terminal domain interface [polypeptide binding]; other site 399741008893 active site 399741008894 MgATP binding site [chemical binding]; other site 399741008895 catalytic site [active] 399741008896 metal binding site [ion binding]; metal-binding site 399741008897 putative homotetramer interface [polypeptide binding]; other site 399741008898 putative homodimer interface [polypeptide binding]; other site 399741008899 putative glycerol binding site [chemical binding]; other site 399741008900 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 399741008901 Domain of unknown function (DUF1937); Region: DUF1937; pfam09152 399741008902 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 399741008903 Predicted dehydrogenase [General function prediction only]; Region: COG0579 399741008904 hydroxyglutarate oxidase; Provisional; Region: PRK11728 399741008905 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 399741008906 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 399741008907 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741008908 Walker A/P-loop; other site 399741008909 ATP binding site [chemical binding]; other site 399741008910 Q-loop/lid; other site 399741008911 ABC transporter signature motif; other site 399741008912 Walker B; other site 399741008913 D-loop; other site 399741008914 H-loop/switch region; other site 399741008915 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 399741008916 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 399741008917 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741008918 Walker A/P-loop; other site 399741008919 ATP binding site [chemical binding]; other site 399741008920 Q-loop/lid; other site 399741008921 ABC transporter signature motif; other site 399741008922 Walker B; other site 399741008923 D-loop; other site 399741008924 H-loop/switch region; other site 399741008925 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 399741008926 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 399741008927 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 399741008928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741008929 dimer interface [polypeptide binding]; other site 399741008930 conserved gate region; other site 399741008931 ABC-ATPase subunit interface; other site 399741008932 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 399741008933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741008934 dimer interface [polypeptide binding]; other site 399741008935 conserved gate region; other site 399741008936 putative PBP binding loops; other site 399741008937 ABC-ATPase subunit interface; other site 399741008938 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 399741008939 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 399741008940 peptide binding site [polypeptide binding]; other site 399741008941 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 399741008942 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 399741008943 peptide binding site [polypeptide binding]; other site 399741008944 hypothetical protein; Provisional; Region: PRK11111 399741008945 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 399741008946 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 399741008947 putative catalytic cysteine [active] 399741008948 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 399741008949 putative active site [active] 399741008950 metal binding site [ion binding]; metal-binding site 399741008951 thymidine kinase; Provisional; Region: PRK04296 399741008952 Uncharacterized conserved protein (DUF2217); Region: DUF2217; pfam10265 399741008953 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 399741008954 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 399741008955 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 399741008956 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 399741008957 putative NAD(P) binding site [chemical binding]; other site 399741008958 active site 399741008959 putative substrate binding site [chemical binding]; other site 399741008960 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 399741008961 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 399741008962 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 399741008963 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 399741008964 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 399741008965 active site 399741008966 tetramer interface; other site 399741008967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741008968 active site 399741008969 response regulator of RpoS; Provisional; Region: PRK10693 399741008970 phosphorylation site [posttranslational modification] 399741008971 intermolecular recognition site; other site 399741008972 dimerization interface [polypeptide binding]; other site 399741008973 hypothetical protein; Provisional; Region: PRK10279 399741008974 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 399741008975 nucleophile elbow; other site 399741008976 SEC-C motif; Region: SEC-C; pfam02810 399741008977 hypothetical protein; Provisional; Region: PRK04233 399741008978 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 399741008979 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 399741008980 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 399741008981 putative active site [active] 399741008982 putative substrate binding site [chemical binding]; other site 399741008983 putative cosubstrate binding site; other site 399741008984 catalytic site [active] 399741008985 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 399741008986 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 399741008987 putative catalytic site [active] 399741008988 putative phosphate binding site [ion binding]; other site 399741008989 active site 399741008990 metal binding site A [ion binding]; metal-binding site 399741008991 DNA binding site [nucleotide binding] 399741008992 putative AP binding site [nucleotide binding]; other site 399741008993 putative metal binding site B [ion binding]; other site 399741008994 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 399741008995 active site 399741008996 8-oxo-dGMP binding site [chemical binding]; other site 399741008997 nudix motif; other site 399741008998 metal binding site [ion binding]; metal-binding site 399741008999 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 399741009000 DNA topoisomerase III; Provisional; Region: PRK07726 399741009001 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 399741009002 active site 399741009003 putative interdomain interaction site [polypeptide binding]; other site 399741009004 putative metal-binding site [ion binding]; other site 399741009005 putative nucleotide binding site [chemical binding]; other site 399741009006 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 399741009007 domain I; other site 399741009008 DNA binding groove [nucleotide binding] 399741009009 phosphate binding site [ion binding]; other site 399741009010 domain II; other site 399741009011 domain III; other site 399741009012 nucleotide binding site [chemical binding]; other site 399741009013 catalytic site [active] 399741009014 domain IV; other site 399741009015 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 399741009016 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 399741009017 active site residue [active] 399741009018 selenophosphate synthetase; Provisional; Region: PRK00943 399741009019 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 399741009020 dimerization interface [polypeptide binding]; other site 399741009021 putative ATP binding site [chemical binding]; other site 399741009022 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 399741009023 putative FMN binding site [chemical binding]; other site 399741009024 protease 4; Provisional; Region: PRK10949 399741009025 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 399741009026 tandem repeat interface [polypeptide binding]; other site 399741009027 oligomer interface [polypeptide binding]; other site 399741009028 active site residues [active] 399741009029 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 399741009030 tandem repeat interface [polypeptide binding]; other site 399741009031 oligomer interface [polypeptide binding]; other site 399741009032 active site residues [active] 399741009033 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 399741009034 active site 399741009035 homodimer interface [polypeptide binding]; other site 399741009036 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 399741009037 Isochorismatase family; Region: Isochorismatase; pfam00857 399741009038 catalytic triad [active] 399741009039 metal binding site [ion binding]; metal-binding site 399741009040 conserved cis-peptide bond; other site 399741009041 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 399741009042 Glyco_18 domain; Region: Glyco_18; smart00636 399741009043 active site 399741009044 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 399741009045 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 399741009046 methionine sulfoxide reductase B; Provisional; Region: PRK00222 399741009047 SelR domain; Region: SelR; pfam01641 399741009048 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 399741009049 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 399741009050 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 399741009051 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 399741009052 active site 399741009053 phosphate binding residues; other site 399741009054 catalytic residues [active] 399741009055 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 399741009056 PrkA family serine protein kinase; Provisional; Region: PRK15455 399741009057 AAA ATPase domain; Region: AAA_16; pfam13191 399741009058 Walker A motif; other site 399741009059 ATP binding site [chemical binding]; other site 399741009060 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 399741009061 hypothetical protein; Provisional; Region: PRK05325 399741009062 Serine hydrolase; Region: Ser_hydrolase; cl17834 399741009063 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 399741009064 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 399741009065 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 399741009066 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 399741009067 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 399741009068 N-terminal plug; other site 399741009069 ligand-binding site [chemical binding]; other site 399741009070 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 399741009071 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741009072 Walker A/P-loop; other site 399741009073 ATP binding site [chemical binding]; other site 399741009074 Q-loop/lid; other site 399741009075 ABC transporter signature motif; other site 399741009076 Walker B; other site 399741009077 D-loop; other site 399741009078 H-loop/switch region; other site 399741009079 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 399741009080 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 399741009081 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741009082 Walker A/P-loop; other site 399741009083 ATP binding site [chemical binding]; other site 399741009084 Q-loop/lid; other site 399741009085 ABC transporter signature motif; other site 399741009086 Walker B; other site 399741009087 D-loop; other site 399741009088 H-loop/switch region; other site 399741009089 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 399741009090 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 399741009091 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 399741009092 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 399741009093 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 399741009094 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 399741009095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 399741009096 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 399741009097 active site 399741009098 substrate binding site [chemical binding]; other site 399741009099 catalytic site [active] 399741009100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741009101 putative substrate translocation pore; other site 399741009102 alanine racemase; Reviewed; Region: dadX; PRK03646 399741009103 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 399741009104 active site 399741009105 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 399741009106 substrate binding site [chemical binding]; other site 399741009107 catalytic residues [active] 399741009108 dimer interface [polypeptide binding]; other site 399741009109 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 399741009110 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 399741009111 hydroxyglutarate oxidase; Provisional; Region: PRK11728 399741009112 SpoVR family protein; Provisional; Region: PRK11767 399741009113 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 399741009114 fatty acid metabolism regulator; Provisional; Region: PRK04984 399741009115 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741009116 DNA-binding site [nucleotide binding]; DNA binding site 399741009117 FadR C-terminal domain; Region: FadR_C; pfam07840 399741009118 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 399741009119 disulfide bond formation protein B; Provisional; Region: PRK01749 399741009120 hypothetical protein; Provisional; Region: PRK05170 399741009121 CsbD-like; Region: CsbD; cl17424 399741009122 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 399741009123 hypothetical protein; Provisional; Region: PRK10691 399741009124 Transglycosylase SLT domain; Region: SLT_2; pfam13406 399741009125 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 399741009126 N-acetyl-D-glucosamine binding site [chemical binding]; other site 399741009127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 399741009128 septum formation inhibitor; Reviewed; Region: minC; PRK03511 399741009129 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 399741009130 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 399741009131 cell division inhibitor MinD; Provisional; Region: PRK10818 399741009132 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 399741009133 Switch I; other site 399741009134 Switch II; other site 399741009135 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 399741009136 ribonuclease D; Provisional; Region: PRK10829 399741009137 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 399741009138 catalytic site [active] 399741009139 putative active site [active] 399741009140 putative substrate binding site [chemical binding]; other site 399741009141 HRDC domain; Region: HRDC; pfam00570 399741009142 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 399741009143 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 399741009144 acyl-activating enzyme (AAE) consensus motif; other site 399741009145 putative AMP binding site [chemical binding]; other site 399741009146 putative active site [active] 399741009147 putative CoA binding site [chemical binding]; other site 399741009148 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 399741009149 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 399741009150 Glycoprotease family; Region: Peptidase_M22; pfam00814 399741009151 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 399741009152 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 399741009153 ATP binding site [chemical binding]; other site 399741009154 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 399741009155 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 399741009156 homotrimer interaction site [polypeptide binding]; other site 399741009157 putative active site [active] 399741009158 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 399741009159 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 399741009160 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 399741009161 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 399741009162 active site 399741009163 intersubunit interface [polypeptide binding]; other site 399741009164 catalytic residue [active] 399741009165 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 399741009166 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 399741009167 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 399741009168 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 399741009169 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 399741009170 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 399741009171 putative active site [active] 399741009172 pyruvate kinase; Provisional; Region: PRK05826 399741009173 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 399741009174 domain interfaces; other site 399741009175 active site 399741009176 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 399741009177 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 399741009178 putative acyl-acceptor binding pocket; other site 399741009179 putative peptidase; Provisional; Region: PRK11649 399741009180 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 399741009181 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 399741009182 Peptidase family M23; Region: Peptidase_M23; pfam01551 399741009183 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 399741009184 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 399741009185 metal binding site [ion binding]; metal-binding site 399741009186 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 399741009187 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 399741009188 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 399741009189 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 399741009190 ABC-ATPase subunit interface; other site 399741009191 dimer interface [polypeptide binding]; other site 399741009192 putative PBP binding regions; other site 399741009193 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 399741009194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741009195 Walker A motif; other site 399741009196 ATP binding site [chemical binding]; other site 399741009197 Walker B motif; other site 399741009198 arginine finger; other site 399741009199 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 399741009200 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 399741009201 RuvA N terminal domain; Region: RuvA_N; pfam01330 399741009202 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 399741009203 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 399741009204 active site 399741009205 putative DNA-binding cleft [nucleotide binding]; other site 399741009206 dimer interface [polypeptide binding]; other site 399741009207 hypothetical protein; Validated; Region: PRK00110 399741009208 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 399741009209 nudix motif; other site 399741009210 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 399741009211 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 399741009212 dimer interface [polypeptide binding]; other site 399741009213 anticodon binding site; other site 399741009214 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 399741009215 homodimer interface [polypeptide binding]; other site 399741009216 motif 1; other site 399741009217 active site 399741009218 motif 2; other site 399741009219 GAD domain; Region: GAD; pfam02938 399741009220 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 399741009221 active site 399741009222 motif 3; other site 399741009223 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 399741009224 Isochorismatase family; Region: Isochorismatase; pfam00857 399741009225 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 399741009226 catalytic triad [active] 399741009227 conserved cis-peptide bond; other site 399741009228 hypothetical protein; Provisional; Region: PRK10302 399741009229 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 399741009230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741009231 S-adenosylmethionine binding site [chemical binding]; other site 399741009232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741009233 S-adenosylmethionine binding site [chemical binding]; other site 399741009234 copper homeostasis protein CutC; Provisional; Region: PRK11572 399741009235 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 399741009236 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741009237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741009238 homodimer interface [polypeptide binding]; other site 399741009239 catalytic residue [active] 399741009240 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 399741009241 putative metal binding site [ion binding]; other site 399741009242 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 399741009243 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 399741009244 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 399741009245 active site 399741009246 HIGH motif; other site 399741009247 KMSK motif region; other site 399741009248 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 399741009249 tRNA binding surface [nucleotide binding]; other site 399741009250 anticodon binding site; other site 399741009251 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 399741009252 MviN-like protein; Region: MVIN; pfam03023 399741009253 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 399741009254 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 399741009255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 399741009256 hypothetical protein; Provisional; Region: PRK11239 399741009257 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 399741009258 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 399741009259 multidrug resistance protein MdtH; Provisional; Region: PRK11646 399741009260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741009261 putative substrate translocation pore; other site 399741009262 glutaredoxin 2; Provisional; Region: PRK10387 399741009263 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 399741009264 C-terminal domain interface [polypeptide binding]; other site 399741009265 GSH binding site (G-site) [chemical binding]; other site 399741009266 catalytic residues [active] 399741009267 putative dimer interface [polypeptide binding]; other site 399741009268 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 399741009269 N-terminal domain interface [polypeptide binding]; other site 399741009270 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 399741009271 ABC1 family; Region: ABC1; pfam03109 399741009272 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 399741009273 active site 399741009274 ATP binding site [chemical binding]; other site 399741009275 lipoprotein; Provisional; Region: PRK10598 399741009276 hypothetical protein; Provisional; Region: PRK13680 399741009277 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 399741009278 YebG protein; Region: YebG; pfam07130 399741009279 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 399741009280 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 399741009281 ATP binding site [chemical binding]; other site 399741009282 Mg++ binding site [ion binding]; other site 399741009283 motif III; other site 399741009284 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 399741009285 nucleotide binding region [chemical binding]; other site 399741009286 ATP-binding site [chemical binding]; other site 399741009287 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 399741009288 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 399741009289 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 399741009290 ATP-grasp domain; Region: ATP-grasp; pfam02222 399741009291 hypothetical protein; Provisional; Region: PRK05114 399741009292 putative glycosyl transferase; Provisional; Region: PRK10073 399741009293 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 399741009294 active site 399741009295 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 399741009296 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 399741009297 chorismate binding enzyme; Region: Chorismate_bind; cl10555 399741009298 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 399741009299 putative active site [active] 399741009300 putative CoA binding site [chemical binding]; other site 399741009301 nudix motif; other site 399741009302 metal binding site [ion binding]; metal-binding site 399741009303 L-serine deaminase; Provisional; Region: PRK15023 399741009304 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 399741009305 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 399741009306 phage resistance protein; Provisional; Region: PRK10551 399741009307 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 399741009308 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 399741009309 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 399741009310 FOG: CBS domain [General function prediction only]; Region: COG0517 399741009311 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 399741009312 Transporter associated domain; Region: CorC_HlyC; smart01091 399741009313 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 399741009314 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 399741009315 active pocket/dimerization site; other site 399741009316 active site 399741009317 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 399741009318 active site 399741009319 phosphorylation site [posttranslational modification] 399741009320 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 399741009321 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 399741009322 hypothetical protein; Provisional; Region: PRK02913 399741009323 Domain of unknown function DUF; Region: DUF204; pfam02659 399741009324 Domain of unknown function DUF; Region: DUF204; pfam02659 399741009325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741009326 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741009327 putative substrate translocation pore; other site 399741009328 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 399741009329 dimerization interface [polypeptide binding]; other site 399741009330 putative DNA binding site [nucleotide binding]; other site 399741009331 putative Zn2+ binding site [ion binding]; other site 399741009332 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 399741009333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741009334 S-adenosylmethionine binding site [chemical binding]; other site 399741009335 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 399741009336 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 399741009337 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 399741009338 DNA-binding site [nucleotide binding]; DNA binding site 399741009339 RNA-binding motif; other site 399741009340 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 399741009341 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 399741009342 aromatic amino acid transporter; Provisional; Region: PRK10238 399741009343 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 399741009344 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 399741009345 YebO-like protein; Region: YebO; pfam13974 399741009346 MgrB protein; Region: MgrB; pfam13998 399741009347 YobH-like protein; Region: YobH; pfam13996 399741009348 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 399741009349 YccJ-like protein; Region: YccJ; pfam13993 399741009350 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 399741009351 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741009352 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 399741009353 Pirin-related protein [General function prediction only]; Region: COG1741 399741009354 Pirin; Region: Pirin; pfam02678 399741009355 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 399741009356 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 399741009357 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 399741009358 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 399741009359 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 399741009360 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 399741009361 trimer interface [polypeptide binding]; other site 399741009362 eyelet of channel; other site 399741009363 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 399741009364 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 399741009365 putative active site [active] 399741009366 Zn binding site [ion binding]; other site 399741009367 succinylarginine dihydrolase; Provisional; Region: PRK13281 399741009368 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 399741009369 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 399741009370 NAD(P) binding site [chemical binding]; other site 399741009371 catalytic residues [active] 399741009372 arginine succinyltransferase; Provisional; Region: PRK10456 399741009373 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 399741009374 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 399741009375 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 399741009376 inhibitor-cofactor binding pocket; inhibition site 399741009377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741009378 catalytic residue [active] 399741009379 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 399741009380 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 399741009381 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 399741009382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741009383 dimer interface [polypeptide binding]; other site 399741009384 conserved gate region; other site 399741009385 putative PBP binding loops; other site 399741009386 ABC-ATPase subunit interface; other site 399741009387 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 399741009388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741009389 dimer interface [polypeptide binding]; other site 399741009390 conserved gate region; other site 399741009391 putative PBP binding loops; other site 399741009392 ABC-ATPase subunit interface; other site 399741009393 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 399741009394 interface (dimer of trimers) [polypeptide binding]; other site 399741009395 Substrate-binding/catalytic site; other site 399741009396 Zn-binding sites [ion binding]; other site 399741009397 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 399741009398 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 399741009399 Walker A/P-loop; other site 399741009400 ATP binding site [chemical binding]; other site 399741009401 Q-loop/lid; other site 399741009402 ABC transporter signature motif; other site 399741009403 Walker B; other site 399741009404 D-loop; other site 399741009405 H-loop/switch region; other site 399741009406 Transcriptional regulators [Transcription]; Region: PurR; COG1609 399741009407 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741009408 DNA binding site [nucleotide binding] 399741009409 domain linker motif; other site 399741009410 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 399741009411 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 399741009412 active site 399741009413 dimer interface [polypeptide binding]; other site 399741009414 catalytic nucleophile [active] 399741009415 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 399741009416 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 399741009417 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 399741009418 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741009419 Walker A/P-loop; other site 399741009420 ATP binding site [chemical binding]; other site 399741009421 Q-loop/lid; other site 399741009422 ABC transporter signature motif; other site 399741009423 Walker B; other site 399741009424 D-loop; other site 399741009425 H-loop/switch region; other site 399741009426 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 399741009427 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 399741009428 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741009429 Walker A/P-loop; other site 399741009430 ATP binding site [chemical binding]; other site 399741009431 Q-loop/lid; other site 399741009432 ABC transporter signature motif; other site 399741009433 Walker B; other site 399741009434 D-loop; other site 399741009435 H-loop/switch region; other site 399741009436 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 399741009437 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 399741009438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741009439 dimer interface [polypeptide binding]; other site 399741009440 conserved gate region; other site 399741009441 putative PBP binding loops; other site 399741009442 ABC-ATPase subunit interface; other site 399741009443 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 399741009444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741009445 dimer interface [polypeptide binding]; other site 399741009446 conserved gate region; other site 399741009447 putative PBP binding loops; other site 399741009448 ABC-ATPase subunit interface; other site 399741009449 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 399741009450 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 399741009451 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 399741009452 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741009453 DNA-binding site [nucleotide binding]; DNA binding site 399741009454 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741009455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741009456 homodimer interface [polypeptide binding]; other site 399741009457 catalytic residue [active] 399741009458 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 399741009459 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 399741009460 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 399741009461 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 399741009462 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 399741009463 Fatty acid desaturase; Region: FA_desaturase; pfam00487 399741009464 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 399741009465 putative di-iron ligands [ion binding]; other site 399741009466 Fatty acid desaturase; Region: FA_desaturase; pfam00487 399741009467 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 399741009468 putative di-iron ligands [ion binding]; other site 399741009469 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 399741009470 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 399741009471 active site 399741009472 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 399741009473 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 399741009474 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 399741009475 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 399741009476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 399741009477 NAD(P) binding site [chemical binding]; other site 399741009478 active site 399741009479 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 399741009480 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 399741009481 dimer interface [polypeptide binding]; other site 399741009482 active site 399741009483 CoA binding pocket [chemical binding]; other site 399741009484 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 399741009485 active site 399741009486 DNA binding site [nucleotide binding] 399741009487 Int/Topo IB signature motif; other site 399741009488 Fimbrial protein; Region: Fimbrial; cl01416 399741009489 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 399741009490 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 399741009491 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 399741009492 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 399741009493 PapC N-terminal domain; Region: PapC_N; pfam13954 399741009494 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 399741009495 PapC C-terminal domain; Region: PapC_C; pfam13953 399741009496 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 399741009497 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 399741009498 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 399741009499 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 399741009500 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741009501 DNA binding residues [nucleotide binding] 399741009502 dimerization interface [polypeptide binding]; other site 399741009503 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 399741009504 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741009505 DNA binding residues [nucleotide binding] 399741009506 dimerization interface [polypeptide binding]; other site 399741009507 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 399741009508 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 399741009509 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 399741009510 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 399741009511 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 399741009512 [4Fe-4S] binding site [ion binding]; other site 399741009513 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 399741009514 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 399741009515 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 399741009516 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 399741009517 molybdopterin cofactor binding site; other site 399741009518 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 399741009519 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 399741009520 active site 399741009521 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 399741009522 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 399741009523 active site 399741009524 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 399741009525 MAPEG family; Region: MAPEG; cl09190 399741009526 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 399741009527 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 399741009528 active site 399741009529 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 399741009530 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 399741009531 putative ADP-binding pocket [chemical binding]; other site 399741009532 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 399741009533 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 399741009534 active site 399741009535 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 399741009536 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 399741009537 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 399741009538 tyrosine kinase; Provisional; Region: PRK11519 399741009539 Chain length determinant protein; Region: Wzz; pfam02706 399741009540 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 399741009541 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 399741009542 polysaccharide export protein Wza; Provisional; Region: PRK15078 399741009543 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 399741009544 SLBB domain; Region: SLBB; pfam10531 399741009545 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 399741009546 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 399741009547 Mg++ binding site [ion binding]; other site 399741009548 putative catalytic motif [active] 399741009549 substrate binding site [chemical binding]; other site 399741009550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 399741009551 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 399741009552 NAD(P) binding site [chemical binding]; other site 399741009553 active site 399741009554 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 399741009555 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741009556 DNA binding site [nucleotide binding] 399741009557 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 399741009558 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 399741009559 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 399741009560 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 399741009561 dimerization interface [polypeptide binding]; other site 399741009562 Histidine kinase; Region: HisKA_3; pfam07730 399741009563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741009564 ATP binding site [chemical binding]; other site 399741009565 Mg2+ binding site [ion binding]; other site 399741009566 G-X-G motif; other site 399741009567 transcriptional regulator NarL; Provisional; Region: PRK10651 399741009568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741009569 active site 399741009570 phosphorylation site [posttranslational modification] 399741009571 intermolecular recognition site; other site 399741009572 dimerization interface [polypeptide binding]; other site 399741009573 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741009574 DNA binding residues [nucleotide binding] 399741009575 dimerization interface [polypeptide binding]; other site 399741009576 putative invasin; Provisional; Region: PRK10177 399741009577 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 399741009578 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 399741009579 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 399741009580 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 399741009581 substrate binding site [chemical binding]; other site 399741009582 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 399741009583 active site 399741009584 SAM binding site [chemical binding]; other site 399741009585 homodimer interface [polypeptide binding]; other site 399741009586 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 399741009587 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 399741009588 [4Fe-4S] binding site [ion binding]; other site 399741009589 molybdopterin cofactor binding site; other site 399741009590 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 399741009591 molybdopterin cofactor binding site; other site 399741009592 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 399741009593 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 399741009594 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 399741009595 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 399741009596 nitrite reductase subunit NirD; Provisional; Region: PRK14989 399741009597 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 399741009598 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 399741009599 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 399741009600 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 399741009601 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 399741009602 Walker A/P-loop; other site 399741009603 ATP binding site [chemical binding]; other site 399741009604 Q-loop/lid; other site 399741009605 ABC transporter signature motif; other site 399741009606 Walker B; other site 399741009607 D-loop; other site 399741009608 H-loop/switch region; other site 399741009609 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 399741009610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741009611 dimer interface [polypeptide binding]; other site 399741009612 conserved gate region; other site 399741009613 putative PBP binding loops; other site 399741009614 ABC-ATPase subunit interface; other site 399741009615 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 399741009616 NMT1-like family; Region: NMT1_2; pfam13379 399741009617 Nitrate and nitrite sensing; Region: NIT; pfam08376 399741009618 ANTAR domain; Region: ANTAR; pfam03861 399741009619 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 399741009620 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 399741009621 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741009622 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 399741009623 Walker A/P-loop; other site 399741009624 ATP binding site [chemical binding]; other site 399741009625 Q-loop/lid; other site 399741009626 ABC transporter signature motif; other site 399741009627 Walker B; other site 399741009628 D-loop; other site 399741009629 H-loop/switch region; other site 399741009630 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 399741009631 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741009632 Walker A/P-loop; other site 399741009633 ATP binding site [chemical binding]; other site 399741009634 Q-loop/lid; other site 399741009635 ABC transporter signature motif; other site 399741009636 Walker B; other site 399741009637 D-loop; other site 399741009638 H-loop/switch region; other site 399741009639 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 399741009640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741009641 dimer interface [polypeptide binding]; other site 399741009642 conserved gate region; other site 399741009643 putative PBP binding loops; other site 399741009644 ABC-ATPase subunit interface; other site 399741009645 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 399741009646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741009647 dimer interface [polypeptide binding]; other site 399741009648 conserved gate region; other site 399741009649 putative PBP binding loops; other site 399741009650 ABC-ATPase subunit interface; other site 399741009651 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 399741009652 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 399741009653 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 399741009654 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 399741009655 substrate binding site [chemical binding]; other site 399741009656 dimerization interface [polypeptide binding]; other site 399741009657 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 399741009658 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 399741009659 putative active site pocket [active] 399741009660 dimerization interface [polypeptide binding]; other site 399741009661 putative catalytic residue [active] 399741009662 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 399741009663 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 399741009664 FAD binding pocket [chemical binding]; other site 399741009665 FAD binding motif [chemical binding]; other site 399741009666 phosphate binding motif [ion binding]; other site 399741009667 NAD binding pocket [chemical binding]; other site 399741009668 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 399741009669 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 399741009670 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 399741009671 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 399741009672 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 399741009673 molybdopterin cofactor binding site; other site 399741009674 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 399741009675 molybdopterin cofactor binding site; other site 399741009676 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 399741009677 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 399741009678 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 399741009679 hypothetical protein; Provisional; Region: PRK10536 399741009680 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 399741009681 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 399741009682 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 399741009683 N-terminal plug; other site 399741009684 ligand-binding site [chemical binding]; other site 399741009685 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 399741009686 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 399741009687 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 399741009688 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 399741009689 Imelysin; Region: Peptidase_M75; pfam09375 399741009690 Iron permease FTR1 family; Region: FTR1; cl00475 399741009691 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 399741009692 Na binding site [ion binding]; other site 399741009693 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 399741009694 Predicted transcriptional regulator [Transcription]; Region: COG3905 399741009695 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 399741009696 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 399741009697 Glutamate binding site [chemical binding]; other site 399741009698 NAD binding site [chemical binding]; other site 399741009699 catalytic residues [active] 399741009700 YcfA-like protein; Region: YcfA; pfam07927 399741009701 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 399741009702 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 399741009703 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 399741009704 Walker A/P-loop; other site 399741009705 ATP binding site [chemical binding]; other site 399741009706 Q-loop/lid; other site 399741009707 ABC transporter signature motif; other site 399741009708 Walker B; other site 399741009709 D-loop; other site 399741009710 H-loop/switch region; other site 399741009711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741009712 dimer interface [polypeptide binding]; other site 399741009713 conserved gate region; other site 399741009714 putative PBP binding loops; other site 399741009715 ABC-ATPase subunit interface; other site 399741009716 cystine transporter subunit; Provisional; Region: PRK11260 399741009717 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741009718 substrate binding pocket [chemical binding]; other site 399741009719 membrane-bound complex binding site; other site 399741009720 hinge residues; other site 399741009721 D-cysteine desulfhydrase; Validated; Region: PRK03910 399741009722 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 399741009723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741009724 catalytic residue [active] 399741009725 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 399741009726 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 399741009727 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 399741009728 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 399741009729 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 399741009730 DNA binding residues [nucleotide binding] 399741009731 flagellin; Validated; Region: PRK06819 399741009732 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 399741009733 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 399741009734 flagellar capping protein; Reviewed; Region: fliD; PRK08032 399741009735 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 399741009736 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 399741009737 flagellar protein FliS; Validated; Region: fliS; PRK05685 399741009738 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 399741009739 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 399741009740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741009741 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 399741009742 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 399741009743 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 399741009744 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 399741009745 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 399741009746 FliG C-terminal domain; Region: FliG_C; pfam01706 399741009747 flagellar assembly protein H; Validated; Region: fliH; PRK05687 399741009748 Flagellar assembly protein FliH; Region: FliH; pfam02108 399741009749 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 399741009750 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 399741009751 Walker A motif/ATP binding site; other site 399741009752 Walker B motif; other site 399741009753 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 399741009754 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 399741009755 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 399741009756 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 399741009757 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 399741009758 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 399741009759 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 399741009760 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 399741009761 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 399741009762 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 399741009763 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 399741009764 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 399741009765 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 399741009766 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 399741009767 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 399741009768 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 399741009769 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 399741009770 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 399741009771 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 399741009772 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 399741009773 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 399741009774 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 399741009775 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 399741009776 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 399741009777 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 399741009778 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 399741009779 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 399741009780 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 399741009781 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 399741009782 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 399741009783 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 399741009784 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 399741009785 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 399741009786 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 399741009787 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 399741009788 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 399741009789 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 399741009790 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 399741009791 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 399741009792 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 399741009793 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 399741009794 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 399741009795 SAF-like; Region: SAF_2; pfam13144 399741009796 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 399741009797 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 399741009798 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 399741009799 FlgN protein; Region: FlgN; cl09176 399741009800 Predicted transcriptional regulator [Transcription]; Region: COG2944 399741009801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741009802 non-specific DNA binding site [nucleotide binding]; other site 399741009803 salt bridge; other site 399741009804 sequence-specific DNA binding site [nucleotide binding]; other site 399741009805 Flagellar protein FlhE; Region: FlhE; pfam06366 399741009806 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 399741009807 FHIPEP family; Region: FHIPEP; pfam00771 399741009808 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 399741009809 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 399741009810 chemotaxis regulator CheZ; Provisional; Region: PRK11166 399741009811 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 399741009812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741009813 active site 399741009814 phosphorylation site [posttranslational modification] 399741009815 intermolecular recognition site; other site 399741009816 dimerization interface [polypeptide binding]; other site 399741009817 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 399741009818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741009819 active site 399741009820 phosphorylation site [posttranslational modification] 399741009821 intermolecular recognition site; other site 399741009822 dimerization interface [polypeptide binding]; other site 399741009823 CheB methylesterase; Region: CheB_methylest; pfam01339 399741009824 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 399741009825 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 399741009826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741009827 methyl-accepting protein IV; Provisional; Region: PRK09793 399741009828 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 399741009829 dimer interface [polypeptide binding]; other site 399741009830 ligand binding site [chemical binding]; other site 399741009831 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 399741009832 dimerization interface [polypeptide binding]; other site 399741009833 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 399741009834 dimer interface [polypeptide binding]; other site 399741009835 putative CheW interface [polypeptide binding]; other site 399741009836 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 399741009837 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 399741009838 dimer interface [polypeptide binding]; other site 399741009839 ligand binding site [chemical binding]; other site 399741009840 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 399741009841 dimerization interface [polypeptide binding]; other site 399741009842 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 399741009843 dimer interface [polypeptide binding]; other site 399741009844 putative CheW interface [polypeptide binding]; other site 399741009845 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 399741009846 putative CheA interaction surface; other site 399741009847 chemotaxis protein CheA; Provisional; Region: PRK10547 399741009848 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 399741009849 putative binding surface; other site 399741009850 active site 399741009851 CheY binding; Region: CheY-binding; pfam09078 399741009852 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 399741009853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741009854 ATP binding site [chemical binding]; other site 399741009855 Mg2+ binding site [ion binding]; other site 399741009856 G-X-G motif; other site 399741009857 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 399741009858 flagellar motor protein MotB; Validated; Region: motB; PRK09041 399741009859 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 399741009860 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 399741009861 ligand binding site [chemical binding]; other site 399741009862 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 399741009863 flagellar motor protein MotA; Validated; Region: PRK09110 399741009864 transcriptional activator FlhC; Provisional; Region: PRK12722 399741009865 transcriptional activator FlhD; Provisional; Region: PRK02909 399741009866 Haemolysin expression modulating protein; Region: HHA; cl11501 399741009867 universal stress protein UspC; Provisional; Region: PRK10116 399741009868 Ligand Binding Site [chemical binding]; other site 399741009869 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 399741009870 Prostaglandin dehydrogenases; Region: PGDH; cd05288 399741009871 NAD(P) binding site [chemical binding]; other site 399741009872 substrate binding site [chemical binding]; other site 399741009873 dimer interface [polypeptide binding]; other site 399741009874 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 399741009875 putative substrate binding pocket [chemical binding]; other site 399741009876 AC domain interface; other site 399741009877 catalytic triad [active] 399741009878 AB domain interface; other site 399741009879 interchain disulfide; other site 399741009880 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741009881 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741009882 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 399741009883 substrate binding pocket [chemical binding]; other site 399741009884 dimerization interface [polypeptide binding]; other site 399741009885 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 399741009886 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 399741009887 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 399741009888 hypothetical protein; Provisional; Region: PRK07033 399741009889 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 399741009890 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 399741009891 ligand binding site [chemical binding]; other site 399741009892 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 399741009893 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 399741009894 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 399741009895 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 399741009896 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 399741009897 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 399741009898 Protein of unknown function (DUF770); Region: DUF770; pfam05591 399741009899 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 399741009900 Protein of unknown function (DUF877); Region: DUF877; pfam05943 399741009901 Protein of unknown function (DUF796); Region: DUF796; pfam05638 399741009902 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 399741009903 phosphopeptide binding site; other site 399741009904 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 399741009905 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 399741009906 active site 399741009907 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 399741009908 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 399741009909 ImpE protein; Region: ImpE; pfam07024 399741009910 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 399741009911 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 399741009912 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 399741009913 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 399741009914 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 399741009915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741009916 Walker A motif; other site 399741009917 ATP binding site [chemical binding]; other site 399741009918 Walker B motif; other site 399741009919 arginine finger; other site 399741009920 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741009921 Walker A motif; other site 399741009922 ATP binding site [chemical binding]; other site 399741009923 Walker B motif; other site 399741009924 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 399741009925 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 399741009926 Catalytic domain of Protein Kinases; Region: PKc; cd00180 399741009927 active site 399741009928 ATP binding site [chemical binding]; other site 399741009929 substrate binding site [chemical binding]; other site 399741009930 activation loop (A-loop); other site 399741009931 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 399741009932 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 399741009933 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 399741009934 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 399741009935 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 399741009936 PAAR motif; Region: PAAR_motif; pfam05488 399741009937 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 399741009938 active site 399741009939 conformational flexibility of ligand binding pocket; other site 399741009940 ADP-ribosylating toxin turn-turn motif; other site 399741009941 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 399741009942 Protein of unknown function (DUF796); Region: DUF796; pfam05638 399741009943 DNA gyrase inhibitor; Provisional; Region: PRK10016 399741009944 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 399741009945 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 399741009946 putative active site [active] 399741009947 putative catalytic site [active] 399741009948 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 399741009949 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 399741009950 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 399741009951 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 399741009952 active site 399741009953 catalytic residues [active] 399741009954 metal binding site [ion binding]; metal-binding site 399741009955 DmpG-like communication domain; Region: DmpG_comm; pfam07836 399741009956 acetaldehyde dehydrogenase; Validated; Region: PRK08300 399741009957 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 399741009958 NAD(P) binding site [chemical binding]; other site 399741009959 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 399741009960 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 399741009961 hypothetical protein; Provisional; Region: PRK07505 399741009962 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 399741009963 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 399741009964 catalytic residue [active] 399741009965 Cupin-like domain; Region: Cupin_8; pfam13621 399741009966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741009967 putative substrate translocation pore; other site 399741009968 H+ Antiporter protein; Region: 2A0121; TIGR00900 399741009969 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 399741009970 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 399741009971 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 399741009972 active site 399741009973 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 399741009974 GAF domain; Region: GAF; pfam01590 399741009975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741009976 Walker A motif; other site 399741009977 ATP binding site [chemical binding]; other site 399741009978 Walker B motif; other site 399741009979 arginine finger; other site 399741009980 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 399741009981 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 399741009982 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 399741009983 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 399741009984 iron binding site [ion binding]; other site 399741009985 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 399741009986 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 399741009987 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 399741009988 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 399741009989 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 399741009990 Autotransporter beta-domain; Region: Autotransporter; smart00869 399741009991 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 399741009992 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 399741009993 Bacterial transcriptional regulator; Region: IclR; pfam01614 399741009994 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 399741009995 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 399741009996 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 399741009997 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 399741009998 dimer interface [polypeptide binding]; other site 399741009999 active site 399741010000 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 399741010001 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 399741010002 magnesium-transporting ATPase; Provisional; Region: PRK15122 399741010003 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 399741010004 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 399741010005 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 399741010006 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741010007 motif II; other site 399741010008 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 399741010009 magnesium transport protein MgtC; Provisional; Region: PRK15385 399741010010 MgtC family; Region: MgtC; pfam02308 399741010011 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 399741010012 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 399741010013 CoA-transferase family III; Region: CoA_transf_3; pfam02515 399741010014 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 399741010015 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741010016 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 399741010017 dimerization interface [polypeptide binding]; other site 399741010018 substrate binding pocket [chemical binding]; other site 399741010019 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 399741010020 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 399741010021 catalytic residue [active] 399741010022 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 399741010023 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741010024 DNA binding residues [nucleotide binding] 399741010025 dimerization interface [polypeptide binding]; other site 399741010026 hypothetical protein; Provisional; Region: PRK10708 399741010027 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 399741010028 DNA-binding site [nucleotide binding]; DNA binding site 399741010029 RNA-binding motif; other site 399741010030 Ion transport protein; Region: Ion_trans; pfam00520 399741010031 Ion channel; Region: Ion_trans_2; pfam07885 399741010032 Double zinc ribbon; Region: DZR; pfam12773 399741010033 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 399741010034 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 399741010035 NAD(P) binding site [chemical binding]; other site 399741010036 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 399741010037 putative catalytic site [active] 399741010038 putative metal binding site [ion binding]; other site 399741010039 putative phosphate binding site [ion binding]; other site 399741010040 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 399741010041 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 399741010042 NAD(P) binding site [chemical binding]; other site 399741010043 active site 399741010044 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741010045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741010046 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 399741010047 putative effector binding pocket; other site 399741010048 dimerization interface [polypeptide binding]; other site 399741010049 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 399741010050 hypothetical protein; Provisional; Region: PRK10457 399741010051 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741010052 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741010053 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 399741010054 putative effector binding pocket; other site 399741010055 putative dimerization interface [polypeptide binding]; other site 399741010056 short chain dehydrogenase; Provisional; Region: PRK12744 399741010057 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 399741010058 NADP binding site [chemical binding]; other site 399741010059 homodimer interface [polypeptide binding]; other site 399741010060 active site 399741010061 substrate binding site [chemical binding]; other site 399741010062 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 399741010063 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 399741010064 dimer interface [polypeptide binding]; other site 399741010065 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 399741010066 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 399741010067 Probable transposase; Region: OrfB_IS605; pfam01385 399741010068 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 399741010069 Transposase IS200 like; Region: Y1_Tnp; cl00848 399741010070 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 399741010071 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 399741010072 metal binding site [ion binding]; metal-binding site 399741010073 active site 399741010074 I-site; other site 399741010075 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 399741010076 Predicted ATPase [General function prediction only]; Region: COG4637 399741010077 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741010078 Walker A/P-loop; other site 399741010079 ATP binding site [chemical binding]; other site 399741010080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741010081 ABC transporter signature motif; other site 399741010082 Walker B; other site 399741010083 D-loop; other site 399741010084 H-loop/switch region; other site 399741010085 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 399741010086 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 399741010087 substrate binding site [chemical binding]; other site 399741010088 dimer interface [polypeptide binding]; other site 399741010089 NADP binding site [chemical binding]; other site 399741010090 catalytic residues [active] 399741010091 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 399741010092 substrate binding site [chemical binding]; other site 399741010093 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 399741010094 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 399741010095 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 399741010096 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 399741010097 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 399741010098 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 399741010099 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 399741010100 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 399741010101 FAD binding pocket [chemical binding]; other site 399741010102 FAD binding motif [chemical binding]; other site 399741010103 phosphate binding motif [ion binding]; other site 399741010104 beta-alpha-beta structure motif; other site 399741010105 NAD(p) ribose binding residues [chemical binding]; other site 399741010106 NAD binding pocket [chemical binding]; other site 399741010107 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 399741010108 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 399741010109 catalytic loop [active] 399741010110 iron binding site [ion binding]; other site 399741010111 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 399741010112 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 399741010113 substrate binding site [chemical binding]; other site 399741010114 oxyanion hole (OAH) forming residues; other site 399741010115 trimer interface [polypeptide binding]; other site 399741010116 enoyl-CoA hydratase; Provisional; Region: PRK08140 399741010117 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 399741010118 substrate binding site [chemical binding]; other site 399741010119 oxyanion hole (OAH) forming residues; other site 399741010120 trimer interface [polypeptide binding]; other site 399741010121 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 399741010122 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 399741010123 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 399741010124 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 399741010125 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 399741010126 CoenzymeA binding site [chemical binding]; other site 399741010127 subunit interaction site [polypeptide binding]; other site 399741010128 PHB binding site; other site 399741010129 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 399741010130 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 399741010131 dimer interface [polypeptide binding]; other site 399741010132 active site 399741010133 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 399741010134 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 399741010135 active site 399741010136 AMP binding site [chemical binding]; other site 399741010137 homodimer interface [polypeptide binding]; other site 399741010138 acyl-activating enzyme (AAE) consensus motif; other site 399741010139 CoA binding site [chemical binding]; other site 399741010140 PaaX-like protein; Region: PaaX; pfam07848 399741010141 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 399741010142 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 399741010143 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 399741010144 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 399741010145 putative trimer interface [polypeptide binding]; other site 399741010146 putative metal binding site [ion binding]; other site 399741010147 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 399741010148 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 399741010149 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 399741010150 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741010151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741010152 homodimer interface [polypeptide binding]; other site 399741010153 catalytic residue [active] 399741010154 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 399741010155 homotrimer interaction site [polypeptide binding]; other site 399741010156 putative active site [active] 399741010157 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 399741010158 LysR family transcriptional regulator; Provisional; Region: PRK14997 399741010159 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741010160 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 399741010161 putative effector binding pocket; other site 399741010162 putative dimerization interface [polypeptide binding]; other site 399741010163 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 399741010164 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 399741010165 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 399741010166 putative N-terminal domain interface [polypeptide binding]; other site 399741010167 putative dimer interface [polypeptide binding]; other site 399741010168 putative substrate binding pocket (H-site) [chemical binding]; other site 399741010169 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 399741010170 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 399741010171 Glycogen synthesis protein; Region: GlgS; pfam08971 399741010172 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 399741010173 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 399741010174 tetramerization interface [polypeptide binding]; other site 399741010175 NAD(P) binding site [chemical binding]; other site 399741010176 catalytic residues [active] 399741010177 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 399741010178 dimer interface [polypeptide binding]; other site 399741010179 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 399741010180 ligand binding site [chemical binding]; other site 399741010181 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 399741010182 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741010183 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741010184 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 399741010185 putative effector binding pocket; other site 399741010186 putative dimerization interface [polypeptide binding]; other site 399741010187 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 399741010188 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 399741010189 Trp docking motif [polypeptide binding]; other site 399741010190 putative active site [active] 399741010191 galactoside permease; Reviewed; Region: lacY; PRK09528 399741010192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741010193 putative substrate translocation pore; other site 399741010194 alpha-galactosidase; Provisional; Region: PRK15076 399741010195 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 399741010196 NAD binding site [chemical binding]; other site 399741010197 sugar binding site [chemical binding]; other site 399741010198 divalent metal binding site [ion binding]; other site 399741010199 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 399741010200 dimer interface [polypeptide binding]; other site 399741010201 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 399741010202 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741010203 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 399741010204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741010205 Chitin binding domain; Region: Chitin_bind_3; cl03871 399741010206 MATE family multidrug exporter; Provisional; Region: PRK10189 399741010207 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 399741010208 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; pfam09691 399741010209 Isochorismatase family; Region: Isochorismatase; pfam00857 399741010210 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 399741010211 catalytic triad [active] 399741010212 conserved cis-peptide bond; other site 399741010213 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 399741010214 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 399741010215 conserved cys residue [active] 399741010216 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741010217 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 399741010218 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 399741010219 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 399741010220 TMP-binding site; other site 399741010221 ATP-binding site [chemical binding]; other site 399741010222 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 399741010223 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 399741010224 Transcriptional regulators [Transcription]; Region: PurR; COG1609 399741010225 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741010226 DNA binding site [nucleotide binding] 399741010227 domain linker motif; other site 399741010228 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 399741010229 putative dimerization interface [polypeptide binding]; other site 399741010230 putative ligand binding site [chemical binding]; other site 399741010231 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 399741010232 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 399741010233 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 399741010234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741010235 dimer interface [polypeptide binding]; other site 399741010236 conserved gate region; other site 399741010237 putative PBP binding loops; other site 399741010238 ABC-ATPase subunit interface; other site 399741010239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741010240 dimer interface [polypeptide binding]; other site 399741010241 conserved gate region; other site 399741010242 putative PBP binding loops; other site 399741010243 ABC-ATPase subunit interface; other site 399741010244 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 399741010245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741010246 Walker A/P-loop; other site 399741010247 ATP binding site [chemical binding]; other site 399741010248 Q-loop/lid; other site 399741010249 ABC transporter signature motif; other site 399741010250 Walker B; other site 399741010251 D-loop; other site 399741010252 H-loop/switch region; other site 399741010253 TOBE domain; Region: TOBE_2; pfam08402 399741010254 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 399741010255 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 399741010256 active site 399741010257 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 399741010258 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 399741010259 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 399741010260 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 399741010261 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 399741010262 conserved cys residue [active] 399741010263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741010264 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741010265 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 399741010266 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 399741010267 Putative transcription activator [Transcription]; Region: TenA; COG0819 399741010268 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 399741010269 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 399741010270 Walker A/P-loop; other site 399741010271 ATP binding site [chemical binding]; other site 399741010272 Q-loop/lid; other site 399741010273 ABC transporter signature motif; other site 399741010274 Walker B; other site 399741010275 D-loop; other site 399741010276 H-loop/switch region; other site 399741010277 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 399741010278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741010279 dimer interface [polypeptide binding]; other site 399741010280 conserved gate region; other site 399741010281 putative PBP binding loops; other site 399741010282 ABC-ATPase subunit interface; other site 399741010283 NMT1/THI5 like; Region: NMT1; pfam09084 399741010284 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 399741010285 phosphoglycerol transferase I; Provisional; Region: PRK03776 399741010286 AMP nucleosidase; Provisional; Region: PRK08292 399741010287 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 399741010288 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 399741010289 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 399741010290 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 399741010291 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741010292 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 399741010293 putative dimerization interface [polypeptide binding]; other site 399741010294 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741010295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741010296 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 399741010297 putative effector binding pocket; other site 399741010298 putative dimerization interface [polypeptide binding]; other site 399741010299 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 399741010300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741010301 putative substrate translocation pore; other site 399741010302 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 399741010303 Transposase; Region: HTH_Tnp_1; pfam01527 399741010304 putative transposase OrfB; Reviewed; Region: PHA02517 399741010305 HTH-like domain; Region: HTH_21; pfam13276 399741010306 Integrase core domain; Region: rve; pfam00665 399741010307 Integrase core domain; Region: rve_3; pfam13683 399741010308 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 399741010309 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 399741010310 active site 399741010311 metal binding site [ion binding]; metal-binding site 399741010312 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741010313 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741010314 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 399741010315 putative effector binding pocket; other site 399741010316 putative dimerization interface [polypeptide binding]; other site 399741010317 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 399741010318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741010319 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 399741010320 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 399741010321 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 399741010322 HlyD family secretion protein; Region: HlyD_3; pfam13437 399741010323 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 399741010324 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741010325 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 399741010326 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 399741010327 active site 399741010328 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 399741010329 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 399741010330 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 399741010331 putative FMN binding site [chemical binding]; other site 399741010332 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 399741010333 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741010334 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741010335 dimerization interface [polypeptide binding]; other site 399741010336 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 399741010337 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 399741010338 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 399741010339 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 399741010340 putative active site [active] 399741010341 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 399741010342 O-Antigen ligase; Region: Wzy_C; pfam04932 399741010343 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 399741010344 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 399741010345 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 399741010346 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 399741010347 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 399741010348 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 399741010349 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741010350 Walker A/P-loop; other site 399741010351 ATP binding site [chemical binding]; other site 399741010352 Q-loop/lid; other site 399741010353 ABC transporter signature motif; other site 399741010354 Walker B; other site 399741010355 D-loop; other site 399741010356 H-loop/switch region; other site 399741010357 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741010358 Walker A/P-loop; other site 399741010359 ATP binding site [chemical binding]; other site 399741010360 Q-loop/lid; other site 399741010361 ABC transporter signature motif; other site 399741010362 Walker B; other site 399741010363 D-loop; other site 399741010364 H-loop/switch region; other site 399741010365 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 399741010366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741010367 putative PBP binding loops; other site 399741010368 ABC-ATPase subunit interface; other site 399741010369 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 399741010370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741010371 dimer interface [polypeptide binding]; other site 399741010372 conserved gate region; other site 399741010373 ABC-ATPase subunit interface; other site 399741010374 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 399741010375 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 399741010376 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 399741010377 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 399741010378 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741010379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741010380 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 399741010381 putative effector binding pocket; other site 399741010382 dimerization interface [polypeptide binding]; other site 399741010383 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 399741010384 Predicted permeases [General function prediction only]; Region: RarD; COG2962 399741010385 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 399741010386 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 399741010387 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 399741010388 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 399741010389 catalytic core [active] 399741010390 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 399741010391 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 399741010392 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 399741010393 transmembrane helices; other site 399741010394 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 399741010395 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 399741010396 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 399741010397 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 399741010398 citrate lyase subunit gamma; Provisional; Region: PRK13253 399741010399 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 399741010400 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 399741010401 putative active site [active] 399741010402 (T/H)XGH motif; other site 399741010403 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 399741010404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741010405 active site 399741010406 phosphorylation site [posttranslational modification] 399741010407 intermolecular recognition site; other site 399741010408 dimerization interface [polypeptide binding]; other site 399741010409 Transcriptional regulator; Region: CitT; pfam12431 399741010410 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 399741010411 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 399741010412 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 399741010413 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 399741010414 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 399741010415 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 399741010416 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 399741010417 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 399741010418 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 399741010419 methionine synthase; Provisional; Region: PRK01207 399741010420 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 399741010421 substrate binding site [chemical binding]; other site 399741010422 THF binding site; other site 399741010423 zinc-binding site [ion binding]; other site 399741010424 hypothetical protein; Provisional; Region: PRK09739 399741010425 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 399741010426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741010427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741010428 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 399741010429 putative effector binding pocket; other site 399741010430 putative dimerization interface [polypeptide binding]; other site 399741010431 citrate-proton symporter; Provisional; Region: PRK15075 399741010432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741010433 putative substrate translocation pore; other site 399741010434 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 399741010435 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 399741010436 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741010437 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741010438 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 399741010439 putative dimerization interface [polypeptide binding]; other site 399741010440 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 399741010441 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 399741010442 putative NAD(P) binding site [chemical binding]; other site 399741010443 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 399741010444 classical (c) SDRs; Region: SDR_c; cd05233 399741010445 NAD(P) binding site [chemical binding]; other site 399741010446 active site 399741010447 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 399741010448 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741010449 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 399741010450 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 399741010451 putative substrate binding site [chemical binding]; other site 399741010452 nucleotide binding site [chemical binding]; other site 399741010453 nucleotide binding site [chemical binding]; other site 399741010454 homodimer interface [polypeptide binding]; other site 399741010455 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 399741010456 Amidinotransferase; Region: Amidinotransf; pfam02274 399741010457 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 399741010458 ornithine carbamoyltransferase; Provisional; Region: PRK00779 399741010459 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 399741010460 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 399741010461 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741010462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741010463 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 399741010464 dimerization interface [polypeptide binding]; other site 399741010465 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 399741010466 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 399741010467 dimer interface [polypeptide binding]; other site 399741010468 active site 399741010469 heme binding site [chemical binding]; other site 399741010470 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 399741010471 benzoate transport; Region: 2A0115; TIGR00895 399741010472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741010473 putative substrate translocation pore; other site 399741010474 putative arabinose transporter; Provisional; Region: PRK03545 399741010475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741010476 putative substrate translocation pore; other site 399741010477 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 399741010478 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 399741010479 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 399741010480 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 399741010481 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 399741010482 Transcriptional regulators [Transcription]; Region: PurR; COG1609 399741010483 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741010484 DNA binding site [nucleotide binding] 399741010485 domain linker motif; other site 399741010486 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 399741010487 putative dimerization interface [polypeptide binding]; other site 399741010488 putative ligand binding site [chemical binding]; other site 399741010489 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 399741010490 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 399741010491 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 399741010492 Walker A/P-loop; other site 399741010493 ATP binding site [chemical binding]; other site 399741010494 Q-loop/lid; other site 399741010495 ABC transporter signature motif; other site 399741010496 Walker B; other site 399741010497 D-loop; other site 399741010498 H-loop/switch region; other site 399741010499 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 399741010500 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 399741010501 Walker A/P-loop; other site 399741010502 ATP binding site [chemical binding]; other site 399741010503 Q-loop/lid; other site 399741010504 ABC transporter signature motif; other site 399741010505 Walker B; other site 399741010506 D-loop; other site 399741010507 H-loop/switch region; other site 399741010508 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 399741010509 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 399741010510 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 399741010511 TM-ABC transporter signature motif; other site 399741010512 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 399741010513 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 399741010514 TM-ABC transporter signature motif; other site 399741010515 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 399741010516 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 399741010517 dimerization interface [polypeptide binding]; other site 399741010518 ligand binding site [chemical binding]; other site 399741010519 transmission-blocking target antigen s230; Provisional; Region: PTZ00415 399741010520 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 399741010521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741010522 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741010523 dimerization interface [polypeptide binding]; other site 399741010524 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 399741010525 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 399741010526 metal binding site [ion binding]; metal-binding site 399741010527 putative dimer interface [polypeptide binding]; other site 399741010528 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 399741010529 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741010530 substrate binding pocket [chemical binding]; other site 399741010531 membrane-bound complex binding site; other site 399741010532 hinge residues; other site 399741010533 hypothetical protein; Provisional; Region: PRK05423 399741010534 Predicted membrane protein [Function unknown]; Region: COG1289 399741010535 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 399741010536 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 399741010537 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 399741010538 amidase catalytic site [active] 399741010539 Zn binding residues [ion binding]; other site 399741010540 substrate binding site [chemical binding]; other site 399741010541 Predicted transcriptional regulator [Transcription]; Region: COG2932 399741010542 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 399741010543 Catalytic site [active] 399741010544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 399741010545 NAD(P) binding site [chemical binding]; other site 399741010546 active site 399741010547 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635 399741010548 exonuclease I; Provisional; Region: sbcB; PRK11779 399741010549 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 399741010550 active site 399741010551 catalytic site [active] 399741010552 substrate binding site [chemical binding]; other site 399741010553 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 399741010554 amino acid transporter; Region: 2A0306; TIGR00909 399741010555 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 399741010556 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 399741010557 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 399741010558 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741010559 non-specific DNA binding site [nucleotide binding]; other site 399741010560 salt bridge; other site 399741010561 sequence-specific DNA binding site [nucleotide binding]; other site 399741010562 Cupin domain; Region: Cupin_2; pfam07883 399741010563 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 399741010564 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 399741010565 Walker A/P-loop; other site 399741010566 ATP binding site [chemical binding]; other site 399741010567 Q-loop/lid; other site 399741010568 ABC transporter signature motif; other site 399741010569 Walker B; other site 399741010570 D-loop; other site 399741010571 H-loop/switch region; other site 399741010572 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 399741010573 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 399741010574 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 399741010575 TM-ABC transporter signature motif; other site 399741010576 putative outer membrane receptor; Provisional; Region: PRK13513 399741010577 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 399741010578 N-terminal plug; other site 399741010579 ligand-binding site [chemical binding]; other site 399741010580 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 399741010581 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 399741010582 Walker A/P-loop; other site 399741010583 ATP binding site [chemical binding]; other site 399741010584 Q-loop/lid; other site 399741010585 ABC transporter signature motif; other site 399741010586 Walker B; other site 399741010587 D-loop; other site 399741010588 H-loop/switch region; other site 399741010589 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 399741010590 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 399741010591 ABC-ATPase subunit interface; other site 399741010592 dimer interface [polypeptide binding]; other site 399741010593 putative PBP binding regions; other site 399741010594 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 399741010595 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 399741010596 metal binding site [ion binding]; metal-binding site 399741010597 active site 399741010598 I-site; other site 399741010599 lysine transporter; Provisional; Region: PRK10836 399741010600 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 399741010601 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741010602 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 399741010603 putative dimerization interface [polypeptide binding]; other site 399741010604 Predicted membrane protein [Function unknown]; Region: COG2855 399741010605 endonuclease IV; Provisional; Region: PRK01060 399741010606 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 399741010607 AP (apurinic/apyrimidinic) site pocket; other site 399741010608 DNA interaction; other site 399741010609 Metal-binding active site; metal-binding site 399741010610 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 399741010611 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 399741010612 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 399741010613 active site 399741010614 P-loop; other site 399741010615 phosphorylation site [posttranslational modification] 399741010616 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 399741010617 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 399741010618 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 399741010619 putative substrate binding site [chemical binding]; other site 399741010620 putative ATP binding site [chemical binding]; other site 399741010621 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 399741010622 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 399741010623 active site 399741010624 phosphorylation site [posttranslational modification] 399741010625 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 399741010626 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 399741010627 dimerization domain swap beta strand [polypeptide binding]; other site 399741010628 regulatory protein interface [polypeptide binding]; other site 399741010629 active site 399741010630 regulatory phosphorylation site [posttranslational modification]; other site 399741010631 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 399741010632 nudix motif; other site 399741010633 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 399741010634 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 399741010635 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 399741010636 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 399741010637 molybdopterin cofactor binding site [chemical binding]; other site 399741010638 substrate binding site [chemical binding]; other site 399741010639 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 399741010640 molybdopterin cofactor binding site; other site 399741010641 sugar efflux transporter B; Provisional; Region: PRK15011 399741010642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741010643 putative substrate translocation pore; other site 399741010644 Flagellin N-methylase; Region: FliB; cl00497 399741010645 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 399741010646 aromatic amino acid transport protein; Region: araaP; TIGR00837 399741010647 elongation factor P; Provisional; Region: PRK04542 399741010648 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 399741010649 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 399741010650 RNA binding site [nucleotide binding]; other site 399741010651 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 399741010652 RNA binding site [nucleotide binding]; other site 399741010653 mannonate dehydratase; Provisional; Region: PRK03906 399741010654 mannonate dehydratase; Region: uxuA; TIGR00695 399741010655 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 399741010656 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 399741010657 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 399741010658 Fimbrial protein; Region: Fimbrial; cl01416 399741010659 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 399741010660 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 399741010661 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 399741010662 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 399741010663 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 399741010664 active site 399741010665 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 399741010666 NlpC/P60 family; Region: NLPC_P60; pfam00877 399741010667 phage resistance protein; Provisional; Region: PRK10551 399741010668 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 399741010669 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 399741010670 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 399741010671 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 399741010672 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 399741010673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741010674 dimer interface [polypeptide binding]; other site 399741010675 conserved gate region; other site 399741010676 putative PBP binding loops; other site 399741010677 ABC-ATPase subunit interface; other site 399741010678 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 399741010679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741010680 dimer interface [polypeptide binding]; other site 399741010681 conserved gate region; other site 399741010682 putative PBP binding loops; other site 399741010683 ABC-ATPase subunit interface; other site 399741010684 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 399741010685 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741010686 Walker A/P-loop; other site 399741010687 ATP binding site [chemical binding]; other site 399741010688 Q-loop/lid; other site 399741010689 ABC transporter signature motif; other site 399741010690 Walker B; other site 399741010691 D-loop; other site 399741010692 H-loop/switch region; other site 399741010693 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 399741010694 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 399741010695 Walker A/P-loop; other site 399741010696 ATP binding site [chemical binding]; other site 399741010697 Q-loop/lid; other site 399741010698 ABC transporter signature motif; other site 399741010699 Walker B; other site 399741010700 D-loop; other site 399741010701 H-loop/switch region; other site 399741010702 hypothetical protein; Provisional; Region: PRK11835 399741010703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741010704 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 399741010705 putative substrate translocation pore; other site 399741010706 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 399741010707 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 399741010708 RNA binding surface [nucleotide binding]; other site 399741010709 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 399741010710 active site 399741010711 uracil binding [chemical binding]; other site 399741010712 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 399741010713 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 399741010714 ATP binding site [chemical binding]; other site 399741010715 putative Mg++ binding site [ion binding]; other site 399741010716 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 399741010717 nucleotide binding region [chemical binding]; other site 399741010718 ATP-binding site [chemical binding]; other site 399741010719 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 399741010720 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 399741010721 5S rRNA interface [nucleotide binding]; other site 399741010722 CTC domain interface [polypeptide binding]; other site 399741010723 L16 interface [polypeptide binding]; other site 399741010724 Nucleoid-associated protein [General function prediction only]; Region: COG3081 399741010725 nucleoid-associated protein NdpA; Validated; Region: PRK00378 399741010726 hypothetical protein; Provisional; Region: PRK13689 399741010727 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 399741010728 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 399741010729 Sulfatase; Region: Sulfatase; cl17466 399741010730 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 399741010731 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 399741010732 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741010733 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741010734 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741010735 dimerization interface [polypeptide binding]; other site 399741010736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 399741010737 SnoaL-like domain; Region: SnoaL_2; pfam12680 399741010738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 399741010739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741010740 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 399741010741 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 399741010742 putative metal binding site [ion binding]; other site 399741010743 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 399741010744 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 399741010745 trimer interface [polypeptide binding]; other site 399741010746 eyelet of channel; other site 399741010747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741010748 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 399741010749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741010750 ATP binding site [chemical binding]; other site 399741010751 Mg2+ binding site [ion binding]; other site 399741010752 G-X-G motif; other site 399741010753 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 399741010754 putative binding surface; other site 399741010755 active site 399741010756 transcriptional regulator RcsB; Provisional; Region: PRK10840 399741010757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741010758 active site 399741010759 phosphorylation site [posttranslational modification] 399741010760 intermolecular recognition site; other site 399741010761 dimerization interface [polypeptide binding]; other site 399741010762 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741010763 DNA binding residues [nucleotide binding] 399741010764 dimerization interface [polypeptide binding]; other site 399741010765 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 399741010766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741010767 dimer interface [polypeptide binding]; other site 399741010768 phosphorylation site [posttranslational modification] 399741010769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741010770 ATP binding site [chemical binding]; other site 399741010771 Mg2+ binding site [ion binding]; other site 399741010772 G-X-G motif; other site 399741010773 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 399741010774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741010775 active site 399741010776 phosphorylation site [posttranslational modification] 399741010777 intermolecular recognition site; other site 399741010778 dimerization interface [polypeptide binding]; other site 399741010779 DNA gyrase subunit A; Validated; Region: PRK05560 399741010780 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 399741010781 CAP-like domain; other site 399741010782 active site 399741010783 primary dimer interface [polypeptide binding]; other site 399741010784 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 399741010785 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 399741010786 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 399741010787 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 399741010788 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 399741010789 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 399741010790 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 399741010791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741010792 S-adenosylmethionine binding site [chemical binding]; other site 399741010793 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 399741010794 ATP cone domain; Region: ATP-cone; pfam03477 399741010795 Class I ribonucleotide reductase; Region: RNR_I; cd01679 399741010796 active site 399741010797 dimer interface [polypeptide binding]; other site 399741010798 catalytic residues [active] 399741010799 effector binding site; other site 399741010800 R2 peptide binding site; other site 399741010801 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 399741010802 dimer interface [polypeptide binding]; other site 399741010803 putative radical transfer pathway; other site 399741010804 diiron center [ion binding]; other site 399741010805 tyrosyl radical; other site 399741010806 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 399741010807 catalytic loop [active] 399741010808 iron binding site [ion binding]; other site 399741010809 Hok/gef family; Region: HOK_GEF; cl11494 399741010810 hypothetical protein; Provisional; Region: PRK03673 399741010811 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 399741010812 putative MPT binding site; other site 399741010813 Competence-damaged protein; Region: CinA; cl00666 399741010814 tyrosine transporter TyrP; Provisional; Region: PRK15132 399741010815 aromatic amino acid transport protein; Region: araaP; TIGR00837 399741010816 YfaZ precursor; Region: YfaZ; pfam07437 399741010817 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 399741010818 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 399741010819 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 399741010820 tetramer interface [polypeptide binding]; other site 399741010821 heme binding pocket [chemical binding]; other site 399741010822 NADPH binding site [chemical binding]; other site 399741010823 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 399741010824 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 399741010825 acyl-activating enzyme (AAE) consensus motif; other site 399741010826 putative AMP binding site [chemical binding]; other site 399741010827 putative active site [active] 399741010828 putative CoA binding site [chemical binding]; other site 399741010829 O-succinylbenzoate synthase; Provisional; Region: PRK05105 399741010830 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 399741010831 active site 399741010832 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 399741010833 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 399741010834 substrate binding site [chemical binding]; other site 399741010835 oxyanion hole (OAH) forming residues; other site 399741010836 trimer interface [polypeptide binding]; other site 399741010837 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 399741010838 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 399741010839 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 399741010840 dimer interface [polypeptide binding]; other site 399741010841 tetramer interface [polypeptide binding]; other site 399741010842 PYR/PP interface [polypeptide binding]; other site 399741010843 TPP binding site [chemical binding]; other site 399741010844 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 399741010845 TPP-binding site; other site 399741010846 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 399741010847 chorismate binding enzyme; Region: Chorismate_bind; cl10555 399741010848 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 399741010849 Putative glucoamylase; Region: Glycoamylase; pfam10091 399741010850 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 399741010851 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 399741010852 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 399741010853 hypothetical protein; Provisional; Region: PRK10404 399741010854 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 399741010855 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 399741010856 putative NAD(P) binding site [chemical binding]; other site 399741010857 catalytic Zn binding site [ion binding]; other site 399741010858 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 399741010859 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 399741010860 NADP binding site [chemical binding]; other site 399741010861 homodimer interface [polypeptide binding]; other site 399741010862 active site 399741010863 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 399741010864 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741010865 DNA binding site [nucleotide binding] 399741010866 domain linker motif; other site 399741010867 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 399741010868 putative ligand binding site [chemical binding]; other site 399741010869 putative dimerization interface [polypeptide binding]; other site 399741010870 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 399741010871 Transmembrane secretion effector; Region: MFS_3; pfam05977 399741010872 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 399741010873 EamA-like transporter family; Region: EamA; pfam00892 399741010874 Cupin domain; Region: Cupin_2; cl17218 399741010875 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 399741010876 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 399741010877 PYR/PP interface [polypeptide binding]; other site 399741010878 dimer interface [polypeptide binding]; other site 399741010879 TPP binding site [chemical binding]; other site 399741010880 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 399741010881 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 399741010882 TPP-binding site [chemical binding]; other site 399741010883 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741010884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741010885 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741010886 dimerization interface [polypeptide binding]; other site 399741010887 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 399741010888 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 399741010889 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 399741010890 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 399741010891 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 399741010892 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 399741010893 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 399741010894 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 399741010895 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 399741010896 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 399741010897 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 399741010898 4Fe-4S binding domain; Region: Fer4; pfam00037 399741010899 4Fe-4S binding domain; Region: Fer4; pfam00037 399741010900 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 399741010901 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 399741010902 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 399741010903 catalytic loop [active] 399741010904 iron binding site [ion binding]; other site 399741010905 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 399741010906 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 399741010907 [4Fe-4S] binding site [ion binding]; other site 399741010908 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 399741010909 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 399741010910 SLBB domain; Region: SLBB; pfam10531 399741010911 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 399741010912 NADH dehydrogenase subunit E; Validated; Region: PRK07539 399741010913 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 399741010914 putative dimer interface [polypeptide binding]; other site 399741010915 [2Fe-2S] cluster binding site [ion binding]; other site 399741010916 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 399741010917 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 399741010918 NADH dehydrogenase subunit D; Validated; Region: PRK06075 399741010919 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 399741010920 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 399741010921 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 399741010922 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741010923 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 399741010924 putative dimerization interface [polypeptide binding]; other site 399741010925 aminotransferase AlaT; Validated; Region: PRK09265 399741010926 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741010927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741010928 homodimer interface [polypeptide binding]; other site 399741010929 catalytic residue [active] 399741010930 5'-nucleotidase; Provisional; Region: PRK03826 399741010931 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 399741010932 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 399741010933 TrkA-C domain; Region: TrkA_C; pfam02080 399741010934 TrkA-C domain; Region: TrkA_C; pfam02080 399741010935 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 399741010936 putative phosphatase; Provisional; Region: PRK11587 399741010937 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741010938 motif II; other site 399741010939 hypothetical protein; Validated; Region: PRK05445 399741010940 hypothetical protein; Provisional; Region: PRK01816 399741010941 propionate/acetate kinase; Provisional; Region: PRK12379 399741010942 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 399741010943 phosphate acetyltransferase; Reviewed; Region: PRK05632 399741010944 DRTGG domain; Region: DRTGG; pfam07085 399741010945 phosphate acetyltransferase; Region: pta; TIGR00651 399741010946 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 399741010947 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 399741010948 nudix motif; other site 399741010949 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 399741010950 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 399741010951 active site 399741010952 metal binding site [ion binding]; metal-binding site 399741010953 homotetramer interface [polypeptide binding]; other site 399741010954 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 399741010955 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 399741010956 C-terminal domain interface [polypeptide binding]; other site 399741010957 GSH binding site (G-site) [chemical binding]; other site 399741010958 dimer interface [polypeptide binding]; other site 399741010959 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 399741010960 N-terminal domain interface [polypeptide binding]; other site 399741010961 putative dimer interface [polypeptide binding]; other site 399741010962 active site 399741010963 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase; Provisional; Region: folX; PRK11245 399741010964 active site 399741010965 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 399741010966 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 399741010967 putative NAD(P) binding site [chemical binding]; other site 399741010968 putative active site [active] 399741010969 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 399741010970 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 399741010971 Walker A/P-loop; other site 399741010972 ATP binding site [chemical binding]; other site 399741010973 Q-loop/lid; other site 399741010974 ABC transporter signature motif; other site 399741010975 Walker B; other site 399741010976 D-loop; other site 399741010977 H-loop/switch region; other site 399741010978 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 399741010979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741010980 dimer interface [polypeptide binding]; other site 399741010981 conserved gate region; other site 399741010982 putative PBP binding loops; other site 399741010983 ABC-ATPase subunit interface; other site 399741010984 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 399741010985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741010986 dimer interface [polypeptide binding]; other site 399741010987 conserved gate region; other site 399741010988 putative PBP binding loops; other site 399741010989 ABC-ATPase subunit interface; other site 399741010990 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741010991 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 399741010992 substrate binding pocket [chemical binding]; other site 399741010993 membrane-bound complex binding site; other site 399741010994 hinge residues; other site 399741010995 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 399741010996 Flavoprotein; Region: Flavoprotein; pfam02441 399741010997 amidophosphoribosyltransferase; Provisional; Region: PRK09246 399741010998 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 399741010999 active site 399741011000 tetramer interface [polypeptide binding]; other site 399741011001 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 399741011002 active site 399741011003 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 399741011004 colicin V production protein; Provisional; Region: PRK10845 399741011005 cell division protein DedD; Provisional; Region: PRK11633 399741011006 Sporulation related domain; Region: SPOR; pfam05036 399741011007 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 399741011008 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 399741011009 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 399741011010 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 399741011011 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 399741011012 hypothetical protein; Provisional; Region: PRK10847 399741011013 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 399741011014 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 399741011015 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 399741011016 dimerization interface 3.5A [polypeptide binding]; other site 399741011017 active site 399741011018 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 399741011019 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 399741011020 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 399741011021 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 399741011022 ligand binding site [chemical binding]; other site 399741011023 NAD binding site [chemical binding]; other site 399741011024 catalytic site [active] 399741011025 homodimer interface [polypeptide binding]; other site 399741011026 Cupin domain; Region: Cupin_2; cl17218 399741011027 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 399741011028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741011029 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 399741011030 EamA-like transporter family; Region: EamA; pfam00892 399741011031 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 399741011032 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 399741011033 HAMP domain; Region: HAMP; pfam00672 399741011034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741011035 dimer interface [polypeptide binding]; other site 399741011036 phosphorylation site [posttranslational modification] 399741011037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741011038 ATP binding site [chemical binding]; other site 399741011039 Mg2+ binding site [ion binding]; other site 399741011040 G-X-G motif; other site 399741011041 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 399741011042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741011043 active site 399741011044 phosphorylation site [posttranslational modification] 399741011045 intermolecular recognition site; other site 399741011046 dimerization interface [polypeptide binding]; other site 399741011047 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741011048 DNA binding site [nucleotide binding] 399741011049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 399741011050 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 399741011051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 399741011052 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 399741011053 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 399741011054 trimer interface [polypeptide binding]; other site 399741011055 active site 399741011056 substrate binding site [chemical binding]; other site 399741011057 CoA binding site [chemical binding]; other site 399741011058 EamA-like transporter family; Region: EamA; pfam00892 399741011059 EamA-like transporter family; Region: EamA; pfam00892 399741011060 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 399741011061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741011062 DNA-binding site [nucleotide binding]; DNA binding site 399741011063 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741011064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741011065 homodimer interface [polypeptide binding]; other site 399741011066 catalytic residue [active] 399741011067 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 399741011068 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 399741011069 catalytic residues [active] 399741011070 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 399741011071 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 399741011072 catalytic residues [active] 399741011073 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 399741011074 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 399741011075 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 399741011076 DsbD alpha interface [polypeptide binding]; other site 399741011077 catalytic residues [active] 399741011078 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 399741011079 H+ Antiporter protein; Region: 2A0121; TIGR00900 399741011080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741011081 putative substrate translocation pore; other site 399741011082 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 399741011083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 399741011084 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 399741011085 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 399741011086 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 399741011087 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 399741011088 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 399741011089 putative catalytic site [active] 399741011090 putative metal binding site [ion binding]; other site 399741011091 putative phosphate binding site [ion binding]; other site 399741011092 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 399741011093 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 399741011094 metal binding site [ion binding]; metal-binding site 399741011095 dimer interface [polypeptide binding]; other site 399741011096 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 399741011097 transmembrane helices; other site 399741011098 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 399741011099 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 399741011100 ApbE family; Region: ApbE; pfam02424 399741011101 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 399741011102 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 399741011103 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 399741011104 HlyD family secretion protein; Region: HlyD_3; pfam13437 399741011105 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 399741011106 Outer membrane efflux protein; Region: OEP; pfam02321 399741011107 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 399741011108 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 399741011109 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 399741011110 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 399741011111 dimer interface [polypeptide binding]; other site 399741011112 active site 399741011113 Uncharacterized conserved protein [Function unknown]; Region: COG4121 399741011114 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 399741011115 YfcL protein; Region: YfcL; pfam08891 399741011116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 399741011117 hypothetical protein; Provisional; Region: PRK10621 399741011118 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 399741011119 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 399741011120 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 399741011121 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 399741011122 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 399741011123 Tetramer interface [polypeptide binding]; other site 399741011124 active site 399741011125 FMN-binding site [chemical binding]; other site 399741011126 HemK family putative methylases; Region: hemK_fam; TIGR00536 399741011127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741011128 S-adenosylmethionine binding site [chemical binding]; other site 399741011129 hypothetical protein; Provisional; Region: PRK04946 399741011130 Smr domain; Region: Smr; pfam01713 399741011131 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 399741011132 catalytic core [active] 399741011133 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 399741011134 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 399741011135 substrate binding site [chemical binding]; other site 399741011136 oxyanion hole (OAH) forming residues; other site 399741011137 trimer interface [polypeptide binding]; other site 399741011138 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 399741011139 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 399741011140 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 399741011141 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 399741011142 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 399741011143 dimer interface [polypeptide binding]; other site 399741011144 active site 399741011145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 399741011146 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 399741011147 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 399741011148 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 399741011149 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 399741011150 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 399741011151 binding surface 399741011152 TPR motif; other site 399741011153 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 399741011154 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 399741011155 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 399741011156 catalytic residues [active] 399741011157 central insert; other site 399741011158 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 399741011159 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 399741011160 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 399741011161 heme exporter protein CcmC; Region: ccmC; TIGR01191 399741011162 heme exporter protein CcmB; Region: ccmB; TIGR01190 399741011163 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 399741011164 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 399741011165 Walker A/P-loop; other site 399741011166 ATP binding site [chemical binding]; other site 399741011167 Q-loop/lid; other site 399741011168 ABC transporter signature motif; other site 399741011169 Walker B; other site 399741011170 D-loop; other site 399741011171 H-loop/switch region; other site 399741011172 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 399741011173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 399741011174 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 399741011175 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741011176 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 399741011177 dimerization interface [polypeptide binding]; other site 399741011178 substrate binding pocket [chemical binding]; other site 399741011179 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 399741011180 EamA-like transporter family; Region: EamA; pfam00892 399741011181 EamA-like transporter family; Region: EamA; pfam00892 399741011182 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 399741011183 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 399741011184 Transglycosylase SLT domain; Region: SLT_2; pfam13406 399741011185 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 399741011186 N-acetyl-D-glucosamine binding site [chemical binding]; other site 399741011187 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 399741011188 aminotransferase; Validated; Region: PRK08175 399741011189 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741011190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741011191 homodimer interface [polypeptide binding]; other site 399741011192 catalytic residue [active] 399741011193 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 399741011194 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741011195 Coenzyme A binding pocket [chemical binding]; other site 399741011196 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 399741011197 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 399741011198 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 399741011199 GAF domain; Region: GAF; pfam01590 399741011200 Histidine kinase; Region: His_kinase; pfam06580 399741011201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741011202 ATP binding site [chemical binding]; other site 399741011203 Mg2+ binding site [ion binding]; other site 399741011204 G-X-G motif; other site 399741011205 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 399741011206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741011207 active site 399741011208 phosphorylation site [posttranslational modification] 399741011209 intermolecular recognition site; other site 399741011210 dimerization interface [polypeptide binding]; other site 399741011211 LytTr DNA-binding domain; Region: LytTR; pfam04397 399741011212 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 399741011213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741011214 putative substrate translocation pore; other site 399741011215 glucokinase; Provisional; Region: glk; PRK00292 399741011216 glucokinase, proteobacterial type; Region: glk; TIGR00749 399741011217 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 399741011218 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 399741011219 Cl- selectivity filter; other site 399741011220 Cl- binding residues [ion binding]; other site 399741011221 pore gating glutamate residue; other site 399741011222 dimer interface [polypeptide binding]; other site 399741011223 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 399741011224 aspartate racemase; Region: asp_race; TIGR00035 399741011225 Predicted membrane protein [Function unknown]; Region: COG4125 399741011226 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 399741011227 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 399741011228 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741011229 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741011230 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 399741011231 dimerization interface [polypeptide binding]; other site 399741011232 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 399741011233 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 399741011234 dimer interface [polypeptide binding]; other site 399741011235 PYR/PP interface [polypeptide binding]; other site 399741011236 TPP binding site [chemical binding]; other site 399741011237 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 399741011238 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 399741011239 TPP-binding site [chemical binding]; other site 399741011240 dimer interface [polypeptide binding]; other site 399741011241 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 399741011242 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 399741011243 active site 399741011244 catalytic tetrad [active] 399741011245 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 399741011246 manganese transport protein MntH; Reviewed; Region: PRK00701 399741011247 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 399741011248 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 399741011249 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 399741011250 Nucleoside recognition; Region: Gate; pfam07670 399741011251 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 399741011252 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 399741011253 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 399741011254 HIGH motif; other site 399741011255 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 399741011256 active site 399741011257 KMSKS motif; other site 399741011258 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 399741011259 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 399741011260 putative NAD(P) binding site [chemical binding]; other site 399741011261 active site 399741011262 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 399741011263 hydrophobic substrate binding pocket; other site 399741011264 Isochorismatase family; Region: Isochorismatase; pfam00857 399741011265 active site 399741011266 conserved cis-peptide bond; other site 399741011267 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 399741011268 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 399741011269 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 399741011270 acyl-activating enzyme (AAE) consensus motif; other site 399741011271 active site 399741011272 AMP binding site [chemical binding]; other site 399741011273 substrate binding site [chemical binding]; other site 399741011274 isochorismate synthase EntC; Provisional; Region: PRK15016 399741011275 chorismate binding enzyme; Region: Chorismate_bind; cl10555 399741011276 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 399741011277 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 399741011278 siderophore binding site; other site 399741011279 enterobactin exporter EntS; Provisional; Region: PRK10489 399741011280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741011281 putative substrate translocation pore; other site 399741011282 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 399741011283 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 399741011284 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 399741011285 ABC-ATPase subunit interface; other site 399741011286 dimer interface [polypeptide binding]; other site 399741011287 putative PBP binding regions; other site 399741011288 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 399741011289 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 399741011290 ABC-ATPase subunit interface; other site 399741011291 dimer interface [polypeptide binding]; other site 399741011292 putative PBP binding regions; other site 399741011293 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 399741011294 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 399741011295 Walker A/P-loop; other site 399741011296 ATP binding site [chemical binding]; other site 399741011297 Q-loop/lid; other site 399741011298 ABC transporter signature motif; other site 399741011299 Walker B; other site 399741011300 D-loop; other site 399741011301 H-loop/switch region; other site 399741011302 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 399741011303 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 399741011304 acyl-activating enzyme (AAE) consensus motif; other site 399741011305 AMP binding site [chemical binding]; other site 399741011306 MbtH-like protein; Region: MbtH; pfam03621 399741011307 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 399741011308 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 399741011309 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 399741011310 outer membrane receptor FepA; Provisional; Region: PRK13524 399741011311 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 399741011312 N-terminal plug; other site 399741011313 ligand-binding site [chemical binding]; other site 399741011314 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 399741011315 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 399741011316 peptide binding site [polypeptide binding]; other site 399741011317 acetolactate synthase; Reviewed; Region: PRK08617 399741011318 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 399741011319 PYR/PP interface [polypeptide binding]; other site 399741011320 dimer interface [polypeptide binding]; other site 399741011321 TPP binding site [chemical binding]; other site 399741011322 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 399741011323 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 399741011324 TPP-binding site [chemical binding]; other site 399741011325 dimer interface [polypeptide binding]; other site 399741011326 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 399741011327 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741011328 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741011329 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 399741011330 putative effector binding pocket; other site 399741011331 dimerization interface [polypeptide binding]; other site 399741011332 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 399741011333 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 399741011334 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 399741011335 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 399741011336 FlxA-like protein; Region: FlxA; pfam14282 399741011337 RES domain; Region: RES; pfam08808 399741011338 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741011339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741011340 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 399741011341 putative dimerization interface [polypeptide binding]; other site 399741011342 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 399741011343 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 399741011344 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 399741011345 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 399741011346 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 399741011347 nucleotide binding pocket [chemical binding]; other site 399741011348 K-X-D-G motif; other site 399741011349 catalytic site [active] 399741011350 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 399741011351 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 399741011352 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 399741011353 DNA binding site [nucleotide binding] 399741011354 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 399741011355 Dimer interface [polypeptide binding]; other site 399741011356 BRCT sequence motif; other site 399741011357 cell division protein ZipA; Provisional; Region: PRK03427 399741011358 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 399741011359 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 399741011360 FtsZ protein binding site [polypeptide binding]; other site 399741011361 putative sulfate transport protein CysZ; Validated; Region: PRK04949 399741011362 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 399741011363 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 399741011364 dimer interface [polypeptide binding]; other site 399741011365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741011366 catalytic residue [active] 399741011367 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 399741011368 dimerization domain swap beta strand [polypeptide binding]; other site 399741011369 regulatory protein interface [polypeptide binding]; other site 399741011370 active site 399741011371 regulatory phosphorylation site [posttranslational modification]; other site 399741011372 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 399741011373 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 399741011374 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 399741011375 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 399741011376 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 399741011377 HPr interaction site; other site 399741011378 glycerol kinase (GK) interaction site [polypeptide binding]; other site 399741011379 active site 399741011380 phosphorylation site [posttranslational modification] 399741011381 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 399741011382 dimerization interface [polypeptide binding]; other site 399741011383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741011384 dimer interface [polypeptide binding]; other site 399741011385 phosphorylation site [posttranslational modification] 399741011386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741011387 ATP binding site [chemical binding]; other site 399741011388 Mg2+ binding site [ion binding]; other site 399741011389 G-X-G motif; other site 399741011390 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 399741011391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741011392 active site 399741011393 phosphorylation site [posttranslational modification] 399741011394 intermolecular recognition site; other site 399741011395 dimerization interface [polypeptide binding]; other site 399741011396 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741011397 DNA binding site [nucleotide binding] 399741011398 cysteine synthase B; Region: cysM; TIGR01138 399741011399 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 399741011400 dimer interface [polypeptide binding]; other site 399741011401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741011402 catalytic residue [active] 399741011403 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 399741011404 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 399741011405 Walker A/P-loop; other site 399741011406 ATP binding site [chemical binding]; other site 399741011407 Q-loop/lid; other site 399741011408 ABC transporter signature motif; other site 399741011409 Walker B; other site 399741011410 D-loop; other site 399741011411 H-loop/switch region; other site 399741011412 TOBE-like domain; Region: TOBE_3; pfam12857 399741011413 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 399741011414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741011415 dimer interface [polypeptide binding]; other site 399741011416 conserved gate region; other site 399741011417 putative PBP binding loops; other site 399741011418 ABC-ATPase subunit interface; other site 399741011419 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 399741011420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741011421 dimer interface [polypeptide binding]; other site 399741011422 conserved gate region; other site 399741011423 putative PBP binding loops; other site 399741011424 ABC-ATPase subunit interface; other site 399741011425 thiosulfate transporter subunit; Provisional; Region: PRK10852 399741011426 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 399741011427 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 399741011428 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 399741011429 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 399741011430 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 399741011431 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 399741011432 putative acetyltransferase; Provisional; Region: PRK03624 399741011433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741011434 Coenzyme A binding pocket [chemical binding]; other site 399741011435 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 399741011436 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 399741011437 active site 399741011438 metal binding site [ion binding]; metal-binding site 399741011439 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 399741011440 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 399741011441 hypothetical protein; Validated; Region: PRK00124 399741011442 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 399741011443 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 399741011444 N-terminal plug; other site 399741011445 ligand-binding site [chemical binding]; other site 399741011446 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 399741011447 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 399741011448 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 399741011449 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 399741011450 Protein of unknown function, DUF399; Region: DUF399; pfam04187 399741011451 S-methylmethionine transporter; Provisional; Region: PRK11387 399741011452 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 399741011453 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 399741011454 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 399741011455 Malic enzyme, N-terminal domain; Region: malic; pfam00390 399741011456 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 399741011457 putative NAD(P) binding site [chemical binding]; other site 399741011458 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 399741011459 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 399741011460 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 399741011461 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 399741011462 Glyco_18 domain; Region: Glyco_18; smart00636 399741011463 active site 399741011464 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 399741011465 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348 399741011466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741011467 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741011468 dimerization interface [polypeptide binding]; other site 399741011469 Chitin binding domain; Region: Chitin_bind_3; pfam03067 399741011470 transaldolase-like protein; Provisional; Region: PTZ00411 399741011471 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 399741011472 active site 399741011473 dimer interface [polypeptide binding]; other site 399741011474 catalytic residue [active] 399741011475 transketolase; Reviewed; Region: PRK12753 399741011476 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 399741011477 TPP-binding site [chemical binding]; other site 399741011478 dimer interface [polypeptide binding]; other site 399741011479 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 399741011480 PYR/PP interface [polypeptide binding]; other site 399741011481 dimer interface [polypeptide binding]; other site 399741011482 TPP binding site [chemical binding]; other site 399741011483 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 399741011484 urease accessory protein UreE; Provisional; Region: ureE; PRK14711 399741011485 UreE urease accessory protein, N-terminal domain; Region: UreE_N; pfam02814 399741011486 dimer interface [polypeptide binding]; other site 399741011487 catalytic residues [active] 399741011488 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 399741011489 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741011490 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 399741011491 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 399741011492 dimer interface [polypeptide binding]; other site 399741011493 ADP-ribose binding site [chemical binding]; other site 399741011494 active site 399741011495 nudix motif; other site 399741011496 metal binding site [ion binding]; metal-binding site 399741011497 cytochrome c-type protein NapC; Provisional; Region: PRK10617 399741011498 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 399741011499 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 399741011500 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 399741011501 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 399741011502 [4Fe-4S] binding site [ion binding]; other site 399741011503 molybdopterin cofactor binding site; other site 399741011504 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 399741011505 molybdopterin cofactor binding site; other site 399741011506 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 399741011507 ferredoxin-type protein NapF; Region: napF; TIGR00402 399741011508 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 399741011509 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 399741011510 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 399741011511 HAMP domain; Region: HAMP; pfam00672 399741011512 Histidine kinase; Region: HisKA_3; pfam07730 399741011513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741011514 ATP binding site [chemical binding]; other site 399741011515 Mg2+ binding site [ion binding]; other site 399741011516 G-X-G motif; other site 399741011517 transcriptional regulator NarP; Provisional; Region: PRK10403 399741011518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741011519 active site 399741011520 phosphorylation site [posttranslational modification] 399741011521 intermolecular recognition site; other site 399741011522 dimerization interface [polypeptide binding]; other site 399741011523 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741011524 DNA binding residues [nucleotide binding] 399741011525 dimerization interface [polypeptide binding]; other site 399741011526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4519 399741011527 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 399741011528 Protein export membrane protein; Region: SecD_SecF; cl14618 399741011529 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 399741011530 putative outer membrane receptor; Provisional; Region: PRK13513 399741011531 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 399741011532 N-terminal plug; other site 399741011533 ligand-binding site [chemical binding]; other site 399741011534 PQQ-like domain; Region: PQQ_2; pfam13360 399741011535 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 399741011536 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 399741011537 N-terminal plug; other site 399741011538 ligand-binding site [chemical binding]; other site 399741011539 Tetratrico peptide repeat; Region: TPR_5; pfam12688 399741011540 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 399741011541 binding surface 399741011542 TPR motif; other site 399741011543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741011544 Coenzyme A binding pocket [chemical binding]; other site 399741011545 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 399741011546 ArsC family; Region: ArsC; pfam03960 399741011547 putative catalytic residues [active] 399741011548 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 399741011549 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 399741011550 metal binding site [ion binding]; metal-binding site 399741011551 dimer interface [polypeptide binding]; other site 399741011552 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 399741011553 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 399741011554 Uncharacterized protein family (UPF0370); Region: UPF0370; pfam13980 399741011555 putative hydrolase; Provisional; Region: PRK11460 399741011556 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 399741011557 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 399741011558 Helicase; Region: Helicase_RecD; pfam05127 399741011559 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 399741011560 Predicted metalloprotease [General function prediction only]; Region: COG2321 399741011561 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 399741011562 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 399741011563 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 399741011564 ATP binding site [chemical binding]; other site 399741011565 active site 399741011566 substrate binding site [chemical binding]; other site 399741011567 lipoprotein; Provisional; Region: PRK11679 399741011568 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 399741011569 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 399741011570 dihydrodipicolinate synthase; Region: dapA; TIGR00674 399741011571 dimer interface [polypeptide binding]; other site 399741011572 active site 399741011573 catalytic residue [active] 399741011574 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 399741011575 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 399741011576 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 399741011577 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 399741011578 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 399741011579 catalytic triad [active] 399741011580 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 399741011581 Domain of unknown function DUF20; Region: UPF0118; pfam01594 399741011582 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 399741011583 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 399741011584 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 399741011585 putative DNA binding site [nucleotide binding]; other site 399741011586 putative Zn2+ binding site [ion binding]; other site 399741011587 AsnC family; Region: AsnC_trans_reg; pfam01037 399741011588 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 399741011589 Predicted transcriptional regulator [Transcription]; Region: COG1959 399741011590 Transcriptional regulator; Region: Rrf2; pfam02082 399741011591 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 399741011592 Peptidase family M48; Region: Peptidase_M48; pfam01435 399741011593 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 399741011594 ArsC family; Region: ArsC; pfam03960 399741011595 catalytic residues [active] 399741011596 DNA replication initiation factor; Provisional; Region: PRK08084 399741011597 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 399741011598 hypothetical protein; Provisional; Region: PRK10457 399741011599 uracil transporter; Provisional; Region: PRK10720 399741011600 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 399741011601 active site 399741011602 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 399741011603 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 399741011604 dimerization interface [polypeptide binding]; other site 399741011605 putative ATP binding site [chemical binding]; other site 399741011606 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 399741011607 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 399741011608 active site 399741011609 substrate binding site [chemical binding]; other site 399741011610 cosubstrate binding site; other site 399741011611 catalytic site [active] 399741011612 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 399741011613 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 399741011614 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741011615 Coenzyme A binding pocket [chemical binding]; other site 399741011616 Protein of unknown function, DUF596; Region: DUF596; pfam04591 399741011617 Protein of unknown function, DUF596; Region: DUF596; pfam04591 399741011618 Xylella fastidiosa protein of unknown function (DUF769); Region: DUF769; pfam05590 399741011619 Protein of unknown function, DUF596; Region: DUF596; pfam04591 399741011620 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 399741011621 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 399741011622 Walker A/P-loop; other site 399741011623 ATP binding site [chemical binding]; other site 399741011624 Q-loop/lid; other site 399741011625 ABC transporter signature motif; other site 399741011626 Walker B; other site 399741011627 D-loop; other site 399741011628 H-loop/switch region; other site 399741011629 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 399741011630 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 399741011631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741011632 dimer interface [polypeptide binding]; other site 399741011633 conserved gate region; other site 399741011634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 399741011635 ABC-ATPase subunit interface; other site 399741011636 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 399741011637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741011638 conserved gate region; other site 399741011639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741011640 conserved gate region; other site 399741011641 putative PBP binding loops; other site 399741011642 ABC-ATPase subunit interface; other site 399741011643 polyphosphate kinase; Provisional; Region: PRK05443 399741011644 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 399741011645 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 399741011646 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 399741011647 domain interface [polypeptide binding]; other site 399741011648 active site 399741011649 catalytic site [active] 399741011650 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 399741011651 domain interface [polypeptide binding]; other site 399741011652 active site 399741011653 catalytic site [active] 399741011654 exopolyphosphatase; Provisional; Region: PRK10854 399741011655 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 399741011656 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 399741011657 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 399741011658 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 399741011659 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 399741011660 MgtE intracellular N domain; Region: MgtE_N; smart00924 399741011661 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 399741011662 Divalent cation transporter; Region: MgtE; pfam01769 399741011663 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 399741011664 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 399741011665 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 399741011666 AlkA N-terminal domain; Region: AlkA_N; pfam06029 399741011667 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 399741011668 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 399741011669 minor groove reading motif; other site 399741011670 helix-hairpin-helix signature motif; other site 399741011671 substrate binding pocket [chemical binding]; other site 399741011672 active site 399741011673 putative chaperone; Provisional; Region: PRK11678 399741011674 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 399741011675 nucleotide binding site [chemical binding]; other site 399741011676 putative NEF/HSP70 interaction site [polypeptide binding]; other site 399741011677 SBD interface [polypeptide binding]; other site 399741011678 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 399741011679 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 399741011680 Predicted kinase [General function prediction only]; Region: COG0645 399741011681 AAA domain; Region: AAA_17; pfam13207 399741011682 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 399741011683 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 399741011684 active site 399741011685 catalytic tetrad [active] 399741011686 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 399741011687 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 399741011688 HlyD family secretion protein; Region: HlyD_3; pfam13437 399741011689 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 399741011690 Protein export membrane protein; Region: SecD_SecF; cl14618 399741011691 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 399741011692 putative transporter; Provisional; Region: PRK10504 399741011693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741011694 putative substrate translocation pore; other site 399741011695 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 399741011696 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 399741011697 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 399741011698 dimerization interface [polypeptide binding]; other site 399741011699 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741011700 dimer interface [polypeptide binding]; other site 399741011701 phosphorylation site [posttranslational modification] 399741011702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741011703 ATP binding site [chemical binding]; other site 399741011704 Mg2+ binding site [ion binding]; other site 399741011705 G-X-G motif; other site 399741011706 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 399741011707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741011708 active site 399741011709 phosphorylation site [posttranslational modification] 399741011710 intermolecular recognition site; other site 399741011711 dimerization interface [polypeptide binding]; other site 399741011712 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741011713 DNA binding site [nucleotide binding] 399741011714 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 399741011715 oligomeric interface; other site 399741011716 putative active site [active] 399741011717 homodimer interface [polypeptide binding]; other site 399741011718 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 399741011719 Uncharacterized conserved protein [Function unknown]; Region: COG3422 399741011720 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 399741011721 putative protease; Provisional; Region: PRK15452 399741011722 Peptidase family U32; Region: Peptidase_U32; pfam01136 399741011723 lipid kinase; Reviewed; Region: PRK13054 399741011724 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 399741011725 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 399741011726 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 399741011727 putative active site pocket [active] 399741011728 putative metal binding site [ion binding]; other site 399741011729 putative oxidoreductase; Provisional; Region: PRK10083 399741011730 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 399741011731 putative NAD(P) binding site [chemical binding]; other site 399741011732 catalytic Zn binding site [ion binding]; other site 399741011733 structural Zn binding site [ion binding]; other site 399741011734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741011735 D-galactonate transporter; Region: 2A0114; TIGR00893 399741011736 putative substrate translocation pore; other site 399741011737 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 399741011738 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 399741011739 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 399741011740 Transcriptional regulators [Transcription]; Region: GntR; COG1802 399741011741 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741011742 DNA-binding site [nucleotide binding]; DNA binding site 399741011743 FCD domain; Region: FCD; pfam07729 399741011744 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 399741011745 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 399741011746 putative active site; other site 399741011747 catalytic residue [active] 399741011748 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 399741011749 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 399741011750 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 399741011751 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 399741011752 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 399741011753 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 399741011754 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 399741011755 putative NAD(P) binding site [chemical binding]; other site 399741011756 active site 399741011757 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 399741011758 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 399741011759 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 399741011760 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 399741011761 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 399741011762 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 399741011763 putative active site [active] 399741011764 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 399741011765 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 399741011766 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 399741011767 dimer interface [polypeptide binding]; other site 399741011768 substrate binding site [chemical binding]; other site 399741011769 ATP binding site [chemical binding]; other site 399741011770 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 399741011771 substrate binding site [chemical binding]; other site 399741011772 multimerization interface [polypeptide binding]; other site 399741011773 ATP binding site [chemical binding]; other site 399741011774 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 399741011775 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741011776 Coenzyme A binding pocket [chemical binding]; other site 399741011777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741011778 putative substrate translocation pore; other site 399741011779 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741011780 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 399741011781 transcriptional regulator protein; Region: phnR; TIGR03337 399741011782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741011783 DNA-binding site [nucleotide binding]; DNA binding site 399741011784 UTRA domain; Region: UTRA; pfam07702 399741011785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741011786 putative substrate translocation pore; other site 399741011787 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741011788 Predicted transcriptional regulators [Transcription]; Region: COG1733 399741011789 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 399741011790 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 399741011791 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 399741011792 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 399741011793 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 399741011794 RNA binding surface [nucleotide binding]; other site 399741011795 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 399741011796 probable active site [active] 399741011797 Autotransporter beta-domain; Region: Autotransporter; pfam03797 399741011798 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 399741011799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741011800 active site 399741011801 phosphorylation site [posttranslational modification] 399741011802 intermolecular recognition site; other site 399741011803 dimerization interface [polypeptide binding]; other site 399741011804 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741011805 DNA binding residues [nucleotide binding] 399741011806 dimerization interface [polypeptide binding]; other site 399741011807 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 399741011808 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741011809 dimer interface [polypeptide binding]; other site 399741011810 phosphorylation site [posttranslational modification] 399741011811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741011812 ATP binding site [chemical binding]; other site 399741011813 Mg2+ binding site [ion binding]; other site 399741011814 G-X-G motif; other site 399741011815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741011816 Response regulator receiver domain; Region: Response_reg; pfam00072 399741011817 active site 399741011818 phosphorylation site [posttranslational modification] 399741011819 intermolecular recognition site; other site 399741011820 dimerization interface [polypeptide binding]; other site 399741011821 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 399741011822 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 399741011823 substrate binding site [chemical binding]; other site 399741011824 oxyanion hole (OAH) forming residues; other site 399741011825 trimer interface [polypeptide binding]; other site 399741011826 Predicted transcriptional regulators [Transcription]; Region: COG1733 399741011827 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 399741011828 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 399741011829 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 399741011830 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 399741011831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741011832 putative substrate translocation pore; other site 399741011833 GMP synthase; Reviewed; Region: guaA; PRK00074 399741011834 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 399741011835 AMP/PPi binding site [chemical binding]; other site 399741011836 candidate oxyanion hole; other site 399741011837 catalytic triad [active] 399741011838 potential glutamine specificity residues [chemical binding]; other site 399741011839 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 399741011840 ATP Binding subdomain [chemical binding]; other site 399741011841 Ligand Binding sites [chemical binding]; other site 399741011842 Dimerization subdomain; other site 399741011843 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 399741011844 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 399741011845 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 399741011846 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 399741011847 active site 399741011848 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 399741011849 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 399741011850 generic binding surface II; other site 399741011851 generic binding surface I; other site 399741011852 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 399741011853 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 399741011854 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 399741011855 putative active site [active] 399741011856 putative catalytic site [active] 399741011857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741011858 D-galactonate transporter; Region: 2A0114; TIGR00893 399741011859 putative substrate translocation pore; other site 399741011860 Transcriptional regulators [Transcription]; Region: PurR; COG1609 399741011861 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741011862 DNA binding site [nucleotide binding] 399741011863 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 399741011864 ligand binding site [chemical binding]; other site 399741011865 dimerization interface [polypeptide binding]; other site 399741011866 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 399741011867 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 399741011868 active site 399741011869 Zn binding site [ion binding]; other site 399741011870 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 399741011871 Predicted permeases [General function prediction only]; Region: COG0679 399741011872 GTP-binding protein Der; Reviewed; Region: PRK00093 399741011873 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 399741011874 G1 box; other site 399741011875 GTP/Mg2+ binding site [chemical binding]; other site 399741011876 Switch I region; other site 399741011877 G2 box; other site 399741011878 Switch II region; other site 399741011879 G3 box; other site 399741011880 G4 box; other site 399741011881 G5 box; other site 399741011882 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 399741011883 G1 box; other site 399741011884 GTP/Mg2+ binding site [chemical binding]; other site 399741011885 Switch I region; other site 399741011886 G2 box; other site 399741011887 G3 box; other site 399741011888 Switch II region; other site 399741011889 G4 box; other site 399741011890 G5 box; other site 399741011891 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 399741011892 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 399741011893 Trp docking motif [polypeptide binding]; other site 399741011894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 399741011895 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 399741011896 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 399741011897 dimer interface [polypeptide binding]; other site 399741011898 motif 1; other site 399741011899 active site 399741011900 motif 2; other site 399741011901 motif 3; other site 399741011902 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 399741011903 anticodon binding site; other site 399741011904 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 399741011905 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 399741011906 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 399741011907 cytoskeletal protein RodZ; Provisional; Region: PRK10856 399741011908 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741011909 non-specific DNA binding site [nucleotide binding]; other site 399741011910 salt bridge; other site 399741011911 sequence-specific DNA binding site [nucleotide binding]; other site 399741011912 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 399741011913 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 399741011914 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 399741011915 binding surface 399741011916 TPR motif; other site 399741011917 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 399741011918 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 399741011919 FeS/SAM binding site; other site 399741011920 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 399741011921 active site 399741011922 multimer interface [polypeptide binding]; other site 399741011923 penicillin-binding protein 1C; Provisional; Region: PRK11240 399741011924 Transglycosylase; Region: Transgly; pfam00912 399741011925 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 399741011926 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 399741011927 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 399741011928 MG2 domain; Region: A2M_N; pfam01835 399741011929 Alpha-2-macroglobulin family; Region: A2M; pfam00207 399741011930 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 399741011931 surface patch; other site 399741011932 thioester region; other site 399741011933 specificity defining residues; other site 399741011934 Transcriptional regulators [Transcription]; Region: PurR; COG1609 399741011935 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741011936 DNA binding site [nucleotide binding] 399741011937 domain linker motif; other site 399741011938 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 399741011939 dimerization interface (closed form) [polypeptide binding]; other site 399741011940 ligand binding site [chemical binding]; other site 399741011941 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 399741011942 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 399741011943 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741011944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741011945 homodimer interface [polypeptide binding]; other site 399741011946 catalytic residue [active] 399741011947 SseB protein; Region: SseB; pfam07179 399741011948 aminopeptidase B; Provisional; Region: PRK05015 399741011949 Peptidase; Region: DUF3663; pfam12404 399741011950 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 399741011951 interface (dimer of trimers) [polypeptide binding]; other site 399741011952 Substrate-binding/catalytic site; other site 399741011953 Zn-binding sites [ion binding]; other site 399741011954 hypothetical protein; Provisional; Region: PRK10721 399741011955 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 399741011956 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 399741011957 catalytic loop [active] 399741011958 iron binding site [ion binding]; other site 399741011959 chaperone protein HscA; Provisional; Region: hscA; PRK05183 399741011960 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 399741011961 nucleotide binding site [chemical binding]; other site 399741011962 putative NEF/HSP70 interaction site [polypeptide binding]; other site 399741011963 SBD interface [polypeptide binding]; other site 399741011964 co-chaperone HscB; Provisional; Region: hscB; PRK05014 399741011965 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 399741011966 HSP70 interaction site [polypeptide binding]; other site 399741011967 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 399741011968 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 399741011969 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 399741011970 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 399741011971 trimerization site [polypeptide binding]; other site 399741011972 active site 399741011973 cysteine desulfurase; Provisional; Region: PRK14012 399741011974 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 399741011975 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 399741011976 catalytic residue [active] 399741011977 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 399741011978 Rrf2 family protein; Region: rrf2_super; TIGR00738 399741011979 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 399741011980 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 399741011981 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 399741011982 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 399741011983 active site 399741011984 dimerization interface [polypeptide binding]; other site 399741011985 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 399741011986 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 399741011987 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 399741011988 PRD domain; Region: PRD; pfam00874 399741011989 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 399741011990 MFS_1 like family; Region: MFS_1_like; pfam12832 399741011991 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 399741011992 active site 399741011993 catalytic motif [active] 399741011994 Zn binding site [ion binding]; other site 399741011995 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 399741011996 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 399741011997 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 399741011998 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 399741011999 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 399741012000 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 399741012001 dimer interface [polypeptide binding]; other site 399741012002 active site 399741012003 glycine-pyridoxal phosphate binding site [chemical binding]; other site 399741012004 folate binding site [chemical binding]; other site 399741012005 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 399741012006 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 399741012007 heme-binding site [chemical binding]; other site 399741012008 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 399741012009 FAD binding pocket [chemical binding]; other site 399741012010 FAD binding motif [chemical binding]; other site 399741012011 phosphate binding motif [ion binding]; other site 399741012012 beta-alpha-beta structure motif; other site 399741012013 NAD binding pocket [chemical binding]; other site 399741012014 Heme binding pocket [chemical binding]; other site 399741012015 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 399741012016 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 399741012017 Cytochrome c; Region: Cytochrom_C; pfam00034 399741012018 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 399741012019 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 399741012020 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 399741012021 tetrameric interface [polypeptide binding]; other site 399741012022 NAD binding site [chemical binding]; other site 399741012023 catalytic residues [active] 399741012024 substrate binding site [chemical binding]; other site 399741012025 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 399741012026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741012027 dimer interface [polypeptide binding]; other site 399741012028 conserved gate region; other site 399741012029 putative PBP binding loops; other site 399741012030 ABC-ATPase subunit interface; other site 399741012031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741012032 dimer interface [polypeptide binding]; other site 399741012033 putative PBP binding loops; other site 399741012034 ABC-ATPase subunit interface; other site 399741012035 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 399741012036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741012037 Walker A/P-loop; other site 399741012038 ATP binding site [chemical binding]; other site 399741012039 Q-loop/lid; other site 399741012040 ABC transporter signature motif; other site 399741012041 Walker B; other site 399741012042 D-loop; other site 399741012043 H-loop/switch region; other site 399741012044 TOBE domain; Region: TOBE_2; pfam08402 399741012045 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 399741012046 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 399741012047 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 399741012048 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 399741012049 tetrameric interface [polypeptide binding]; other site 399741012050 NAD binding site [chemical binding]; other site 399741012051 catalytic residues [active] 399741012052 substrate binding site [chemical binding]; other site 399741012053 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741012054 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741012055 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 399741012056 putative substrate binding pocket [chemical binding]; other site 399741012057 dimerization interface [polypeptide binding]; other site 399741012058 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 399741012059 Nitrogen regulatory protein P-II; Region: P-II; smart00938 399741012060 NAD synthetase; Provisional; Region: PRK13981 399741012061 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 399741012062 multimer interface [polypeptide binding]; other site 399741012063 active site 399741012064 catalytic triad [active] 399741012065 protein interface 1 [polypeptide binding]; other site 399741012066 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 399741012067 homodimer interface [polypeptide binding]; other site 399741012068 NAD binding pocket [chemical binding]; other site 399741012069 ATP binding pocket [chemical binding]; other site 399741012070 Mg binding site [ion binding]; other site 399741012071 active-site loop [active] 399741012072 response regulator GlrR; Provisional; Region: PRK15115 399741012073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741012074 active site 399741012075 phosphorylation site [posttranslational modification] 399741012076 intermolecular recognition site; other site 399741012077 dimerization interface [polypeptide binding]; other site 399741012078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741012079 Walker A motif; other site 399741012080 ATP binding site [chemical binding]; other site 399741012081 Walker B motif; other site 399741012082 arginine finger; other site 399741012083 hypothetical protein; Provisional; Region: PRK10722 399741012084 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 399741012085 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741012086 dimer interface [polypeptide binding]; other site 399741012087 phosphorylation site [posttranslational modification] 399741012088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741012089 ATP binding site [chemical binding]; other site 399741012090 Mg2+ binding site [ion binding]; other site 399741012091 G-X-G motif; other site 399741012092 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 399741012093 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 399741012094 dimerization interface [polypeptide binding]; other site 399741012095 ATP binding site [chemical binding]; other site 399741012096 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 399741012097 dimerization interface [polypeptide binding]; other site 399741012098 ATP binding site [chemical binding]; other site 399741012099 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 399741012100 putative active site [active] 399741012101 catalytic triad [active] 399741012102 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 399741012103 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741012104 substrate binding pocket [chemical binding]; other site 399741012105 membrane-bound complex binding site; other site 399741012106 hinge residues; other site 399741012107 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 399741012108 N-acetyl-D-glucosamine binding site [chemical binding]; other site 399741012109 catalytic residue [active] 399741012110 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 399741012111 nucleoside/Zn binding site; other site 399741012112 dimer interface [polypeptide binding]; other site 399741012113 catalytic motif [active] 399741012114 putative alcohol dehydrogenase; Provisional; Region: PRK09860 399741012115 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 399741012116 dimer interface [polypeptide binding]; other site 399741012117 active site 399741012118 metal binding site [ion binding]; metal-binding site 399741012119 hypothetical protein; Provisional; Region: PRK11590 399741012120 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 399741012121 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 399741012122 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 399741012123 active site turn [active] 399741012124 phosphorylation site [posttranslational modification] 399741012125 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 399741012126 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 399741012127 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 399741012128 putative active site [active] 399741012129 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 399741012130 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 399741012131 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 399741012132 putative active site [active] 399741012133 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 399741012134 Sulfatase; Region: Sulfatase; cl17466 399741012135 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 399741012136 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 399741012137 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 399741012138 active site 399741012139 hydrophilic channel; other site 399741012140 dimerization interface [polypeptide binding]; other site 399741012141 catalytic residues [active] 399741012142 active site lid [active] 399741012143 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 399741012144 Recombination protein O N terminal; Region: RecO_N; pfam11967 399741012145 Recombination protein O C terminal; Region: RecO_C; pfam02565 399741012146 GTPase Era; Reviewed; Region: era; PRK00089 399741012147 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 399741012148 G1 box; other site 399741012149 GTP/Mg2+ binding site [chemical binding]; other site 399741012150 Switch I region; other site 399741012151 G2 box; other site 399741012152 Switch II region; other site 399741012153 G3 box; other site 399741012154 G4 box; other site 399741012155 G5 box; other site 399741012156 KH domain; Region: KH_2; pfam07650 399741012157 ribonuclease III; Reviewed; Region: rnc; PRK00102 399741012158 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 399741012159 dimerization interface [polypeptide binding]; other site 399741012160 active site 399741012161 metal binding site [ion binding]; metal-binding site 399741012162 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 399741012163 dsRNA binding site [nucleotide binding]; other site 399741012164 signal peptidase I; Provisional; Region: PRK10861 399741012165 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 399741012166 Catalytic site [active] 399741012167 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 399741012168 GTP-binding protein LepA; Provisional; Region: PRK05433 399741012169 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 399741012170 G1 box; other site 399741012171 putative GEF interaction site [polypeptide binding]; other site 399741012172 GTP/Mg2+ binding site [chemical binding]; other site 399741012173 Switch I region; other site 399741012174 G2 box; other site 399741012175 G3 box; other site 399741012176 Switch II region; other site 399741012177 G4 box; other site 399741012178 G5 box; other site 399741012179 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 399741012180 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 399741012181 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 399741012182 SoxR reducing system protein RseC; Provisional; Region: PRK10862 399741012183 anti-sigma E factor; Provisional; Region: rseB; PRK09455 399741012184 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 399741012185 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 399741012186 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 399741012187 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 399741012188 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 399741012189 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 399741012190 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 399741012191 DNA binding residues [nucleotide binding] 399741012192 L-aspartate oxidase; Provisional; Region: PRK09077 399741012193 L-aspartate oxidase; Provisional; Region: PRK06175 399741012194 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 399741012195 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 399741012196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741012197 S-adenosylmethionine binding site [chemical binding]; other site 399741012198 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 399741012199 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 399741012200 ATP binding site [chemical binding]; other site 399741012201 Mg++ binding site [ion binding]; other site 399741012202 motif III; other site 399741012203 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 399741012204 nucleotide binding region [chemical binding]; other site 399741012205 ATP-binding site [chemical binding]; other site 399741012206 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 399741012207 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 399741012208 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 399741012209 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 399741012210 ligand binding site [chemical binding]; other site 399741012211 active site 399741012212 UGI interface [polypeptide binding]; other site 399741012213 catalytic site [active] 399741012214 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 399741012215 dimer interface [polypeptide binding]; other site 399741012216 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 399741012217 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 399741012218 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 399741012219 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 399741012220 recombination and repair protein; Provisional; Region: PRK10869 399741012221 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 399741012222 Walker A/P-loop; other site 399741012223 ATP binding site [chemical binding]; other site 399741012224 Q-loop/lid; other site 399741012225 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 399741012226 ABC transporter signature motif; other site 399741012227 Walker B; other site 399741012228 D-loop; other site 399741012229 H-loop/switch region; other site 399741012230 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 399741012231 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 399741012232 hypothetical protein; Validated; Region: PRK01777 399741012233 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 399741012234 putative coenzyme Q binding site [chemical binding]; other site 399741012235 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 399741012236 SmpB-tmRNA interface; other site 399741012237 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 399741012238 HipA-like N-terminal domain; Region: HipA_N; pfam07805 399741012239 HipA-like C-terminal domain; Region: HipA_C; pfam07804 399741012240 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 399741012241 non-specific DNA binding site [nucleotide binding]; other site 399741012242 salt bridge; other site 399741012243 sequence-specific DNA binding site [nucleotide binding]; other site 399741012244 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 399741012245 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 399741012246 HlyD family secretion protein; Region: HlyD_3; pfam13437 399741012247 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 399741012248 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 399741012249 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741012250 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741012251 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741012252 dimerization interface [polypeptide binding]; other site 399741012253 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 399741012254 dimer interface [polypeptide binding]; other site 399741012255 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 399741012256 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 399741012257 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 399741012258 HlyD family secretion protein; Region: HlyD_3; pfam13437 399741012259 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 399741012260 Protein export membrane protein; Region: SecD_SecF; cl14618 399741012261 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 399741012262 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 399741012263 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741012264 Coenzyme A binding pocket [chemical binding]; other site 399741012265 Methyltransferase domain; Region: Methyltransf_31; pfam13847 399741012266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741012267 S-adenosylmethionine binding site [chemical binding]; other site 399741012268 Predicted acetyltransferase [General function prediction only]; Region: COG2388 399741012269 Predicted membrane protein [Function unknown]; Region: COG2259 399741012270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 399741012271 Smr domain; Region: Smr; pfam01713 399741012272 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 399741012273 hypothetical protein; Provisional; Region: PRK10556 399741012274 major facilitator superfamily transporter; Provisional; Region: PRK05122 399741012275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741012276 putative substrate translocation pore; other site 399741012277 Helix-turn-helix domain; Region: HTH_18; pfam12833 399741012278 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741012279 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 399741012280 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741012281 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741012282 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 399741012283 putative effector binding pocket; other site 399741012284 dimerization interface [polypeptide binding]; other site 399741012285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741012286 putative substrate translocation pore; other site 399741012287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741012288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 399741012289 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 399741012290 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 399741012291 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741012292 DNA-binding site [nucleotide binding]; DNA binding site 399741012293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741012294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741012295 homodimer interface [polypeptide binding]; other site 399741012296 catalytic residue [active] 399741012297 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 399741012298 Uncharacterized conserved protein [Function unknown]; Region: COG2128 399741012299 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 399741012300 catalytic residues [active] 399741012301 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 399741012302 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 399741012303 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 399741012304 Class I ribonucleotide reductase; Region: RNR_I; cd01679 399741012305 active site 399741012306 dimer interface [polypeptide binding]; other site 399741012307 catalytic residues [active] 399741012308 effector binding site; other site 399741012309 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 399741012310 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 399741012311 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 399741012312 dimer interface [polypeptide binding]; other site 399741012313 putative radical transfer pathway; other site 399741012314 diiron center [ion binding]; other site 399741012315 tyrosyl radical; other site 399741012316 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 399741012317 short chain dehydrogenase; Provisional; Region: PRK12937 399741012318 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 399741012319 NADP binding site [chemical binding]; other site 399741012320 homodimer interface [polypeptide binding]; other site 399741012321 active site 399741012322 substrate binding site [chemical binding]; other site 399741012323 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741012324 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741012325 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 399741012326 putative effector binding pocket; other site 399741012327 putative dimerization interface [polypeptide binding]; other site 399741012328 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 399741012329 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 399741012330 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 399741012331 PAS domain; Region: PAS; smart00091 399741012332 putative active site [active] 399741012333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741012334 ATP binding site [chemical binding]; other site 399741012335 Mg2+ binding site [ion binding]; other site 399741012336 G-X-G motif; other site 399741012337 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 399741012338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741012339 active site 399741012340 phosphorylation site [posttranslational modification] 399741012341 intermolecular recognition site; other site 399741012342 dimerization interface [polypeptide binding]; other site 399741012343 Transcriptional regulator; Region: CitT; pfam12431 399741012344 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 399741012345 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 399741012346 Walker A/P-loop; other site 399741012347 ATP binding site [chemical binding]; other site 399741012348 Q-loop/lid; other site 399741012349 ABC transporter signature motif; other site 399741012350 Walker B; other site 399741012351 D-loop; other site 399741012352 H-loop/switch region; other site 399741012353 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 399741012354 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 399741012355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741012356 dimer interface [polypeptide binding]; other site 399741012357 conserved gate region; other site 399741012358 putative PBP binding loops; other site 399741012359 ABC-ATPase subunit interface; other site 399741012360 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 399741012361 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 399741012362 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 399741012363 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 399741012364 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741012365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741012366 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 399741012367 putative dimerization interface [polypeptide binding]; other site 399741012368 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 399741012369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741012370 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 399741012371 putative L-valine exporter; Provisional; Region: PRK10408 399741012372 transcriptional repressor MprA; Provisional; Region: PRK10870 399741012373 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 399741012374 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 399741012375 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 399741012376 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 399741012377 HlyD family secretion protein; Region: HlyD_3; pfam13437 399741012378 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 399741012379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741012380 putative substrate translocation pore; other site 399741012381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741012382 putative methyltransferase; Provisional; Region: PRK10864 399741012383 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 399741012384 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 399741012385 thioredoxin 2; Provisional; Region: PRK10996 399741012386 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 399741012387 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 399741012388 catalytic residues [active] 399741012389 Uncharacterized conserved protein [Function unknown]; Region: COG3148 399741012390 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 399741012391 CoA binding domain; Region: CoA_binding_2; pfam13380 399741012392 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 399741012393 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 399741012394 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 399741012395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741012396 Coenzyme A binding pocket [chemical binding]; other site 399741012397 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 399741012398 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 399741012399 domain interface [polypeptide binding]; other site 399741012400 putative active site [active] 399741012401 catalytic site [active] 399741012402 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 399741012403 domain interface [polypeptide binding]; other site 399741012404 putative active site [active] 399741012405 catalytic site [active] 399741012406 lipoprotein; Provisional; Region: PRK10759 399741012407 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 399741012408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741012409 putative substrate translocation pore; other site 399741012410 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 399741012411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741012412 active site 399741012413 motif I; other site 399741012414 motif II; other site 399741012415 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 399741012416 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 399741012417 Walker A/P-loop; other site 399741012418 ATP binding site [chemical binding]; other site 399741012419 Q-loop/lid; other site 399741012420 ABC transporter signature motif; other site 399741012421 Walker B; other site 399741012422 D-loop; other site 399741012423 H-loop/switch region; other site 399741012424 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 399741012425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741012426 dimer interface [polypeptide binding]; other site 399741012427 conserved gate region; other site 399741012428 ABC-ATPase subunit interface; other site 399741012429 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 399741012430 lipoprotein, YaeC family; Region: TIGR00363 399741012431 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 399741012432 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 399741012433 homodimer interaction site [polypeptide binding]; other site 399741012434 cofactor binding site; other site 399741012435 prolyl-tRNA synthetase; Provisional; Region: PRK09194 399741012436 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 399741012437 dimer interface [polypeptide binding]; other site 399741012438 motif 1; other site 399741012439 active site 399741012440 motif 2; other site 399741012441 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 399741012442 putative deacylase active site [active] 399741012443 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 399741012444 active site 399741012445 motif 3; other site 399741012446 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 399741012447 anticodon binding site; other site 399741012448 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 399741012449 NlpE N-terminal domain; Region: NlpE; pfam04170 399741012450 hypothetical protein; Provisional; Region: PRK09256 399741012451 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 399741012452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 399741012453 hypothetical protein; Provisional; Region: PRK04964 399741012454 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 399741012455 Cytochrome c553 [Energy production and conversion]; Region: COG2863 399741012456 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 399741012457 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 399741012458 Ligand Binding Site [chemical binding]; other site 399741012459 TilS substrate binding domain; Region: TilS; pfam09179 399741012460 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 399741012461 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 399741012462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741012463 putative substrate translocation pore; other site 399741012464 POT family; Region: PTR2; pfam00854 399741012465 lysine decarboxylase CadA; Provisional; Region: PRK15400 399741012466 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 399741012467 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 399741012468 homodimer interface [polypeptide binding]; other site 399741012469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741012470 catalytic residue [active] 399741012471 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 399741012472 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 399741012473 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 399741012474 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741012475 DNA binding site [nucleotide binding] 399741012476 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 399741012477 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 399741012478 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 399741012479 putative metal binding site [ion binding]; other site 399741012480 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 399741012481 Transcriptional regulators [Transcription]; Region: MarR; COG1846 399741012482 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 399741012483 putative Zn2+ binding site [ion binding]; other site 399741012484 putative DNA binding site [nucleotide binding]; other site 399741012485 lysine decarboxylase LdcC; Provisional; Region: PRK15399 399741012486 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 399741012487 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 399741012488 homodimer interface [polypeptide binding]; other site 399741012489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741012490 catalytic residue [active] 399741012491 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 399741012492 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 399741012493 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 399741012494 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 399741012495 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 399741012496 putative active site [active] 399741012497 putative PHP Thumb interface [polypeptide binding]; other site 399741012498 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 399741012499 generic binding surface II; other site 399741012500 generic binding surface I; other site 399741012501 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 399741012502 RNA/DNA hybrid binding site [nucleotide binding]; other site 399741012503 active site 399741012504 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 399741012505 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 399741012506 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 399741012507 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 399741012508 active site 399741012509 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 399741012510 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 399741012511 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 399741012512 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 399741012513 trimer interface [polypeptide binding]; other site 399741012514 active site 399741012515 UDP-GlcNAc binding site [chemical binding]; other site 399741012516 lipid binding site [chemical binding]; lipid-binding site 399741012517 periplasmic chaperone; Provisional; Region: PRK10780 399741012518 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 399741012519 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 399741012520 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 399741012521 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 399741012522 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 399741012523 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 399741012524 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 399741012525 Surface antigen; Region: Bac_surface_Ag; pfam01103 399741012526 zinc metallopeptidase RseP; Provisional; Region: PRK10779 399741012527 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 399741012528 active site 399741012529 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 399741012530 protein binding site [polypeptide binding]; other site 399741012531 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 399741012532 protein binding site [polypeptide binding]; other site 399741012533 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 399741012534 putative substrate binding region [chemical binding]; other site 399741012535 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 399741012536 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 399741012537 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 399741012538 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 399741012539 catalytic residue [active] 399741012540 putative FPP diphosphate binding site; other site 399741012541 putative FPP binding hydrophobic cleft; other site 399741012542 dimer interface [polypeptide binding]; other site 399741012543 putative IPP diphosphate binding site; other site 399741012544 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 399741012545 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 399741012546 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 399741012547 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 399741012548 ribosome recycling factor; Reviewed; Region: frr; PRK00083 399741012549 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 399741012550 hinge region; other site 399741012551 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 399741012552 putative nucleotide binding site [chemical binding]; other site 399741012553 uridine monophosphate binding site [chemical binding]; other site 399741012554 homohexameric interface [polypeptide binding]; other site 399741012555 elongation factor Ts; Provisional; Region: tsf; PRK09377 399741012556 UBA/TS-N domain; Region: UBA; pfam00627 399741012557 Elongation factor TS; Region: EF_TS; pfam00889 399741012558 Elongation factor TS; Region: EF_TS; pfam00889 399741012559 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 399741012560 rRNA interaction site [nucleotide binding]; other site 399741012561 S8 interaction site; other site 399741012562 putative laminin-1 binding site; other site 399741012563 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 399741012564 active site 399741012565 PII uridylyl-transferase; Provisional; Region: PRK05007 399741012566 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 399741012567 metal binding triad; other site 399741012568 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 399741012569 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 399741012570 Zn2+ binding site [ion binding]; other site 399741012571 Mg2+ binding site [ion binding]; other site 399741012572 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 399741012573 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 399741012574 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 399741012575 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 399741012576 trimer interface [polypeptide binding]; other site 399741012577 active site 399741012578 substrate binding site [chemical binding]; other site 399741012579 CoA binding site [chemical binding]; other site 399741012580 hypothetical protein; Provisional; Region: PRK13677 399741012581 flavodoxin; Provisional; Region: PRK08105 399741012582 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 399741012583 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 399741012584 probable active site [active] 399741012585 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 399741012586 benzoate transport; Region: 2A0115; TIGR00895 399741012587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741012588 putative substrate translocation pore; other site 399741012589 SecY interacting protein Syd; Provisional; Region: PRK04968 399741012590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 399741012591 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 399741012592 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 399741012593 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 399741012594 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 399741012595 flap endonuclease-like protein; Provisional; Region: PRK09482 399741012596 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 399741012597 active site 399741012598 metal binding site 1 [ion binding]; metal-binding site 399741012599 putative 5' ssDNA interaction site; other site 399741012600 metal binding site 3; metal-binding site 399741012601 metal binding site 2 [ion binding]; metal-binding site 399741012602 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 399741012603 putative DNA binding site [nucleotide binding]; other site 399741012604 putative metal binding site [ion binding]; other site 399741012605 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 399741012606 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 399741012607 hypothetical protein; Provisional; Region: PRK10873 399741012608 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 399741012609 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741012610 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 399741012611 dimerization interface [polypeptide binding]; other site 399741012612 substrate binding pocket [chemical binding]; other site 399741012613 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 399741012614 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 399741012615 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 399741012616 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 399741012617 catalytic residue [active] 399741012618 Fe-S metabolism associated domain; Region: SufE; cl00951 399741012619 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 399741012620 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 399741012621 putative ATP binding site [chemical binding]; other site 399741012622 putative substrate interface [chemical binding]; other site 399741012623 murein transglycosylase A; Provisional; Region: mltA; PRK11162 399741012624 MltA specific insert domain; Region: MltA; smart00925 399741012625 3D domain; Region: 3D; pfam06725 399741012626 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 399741012627 AMIN domain; Region: AMIN; pfam11741 399741012628 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 399741012629 active site 399741012630 metal binding site [ion binding]; metal-binding site 399741012631 N-acetylglutamate synthase; Validated; Region: PRK05279 399741012632 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 399741012633 putative feedback inhibition sensing region; other site 399741012634 putative nucleotide binding site [chemical binding]; other site 399741012635 putative substrate binding site [chemical binding]; other site 399741012636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741012637 Coenzyme A binding pocket [chemical binding]; other site 399741012638 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 399741012639 AAA domain; Region: AAA_30; pfam13604 399741012640 Family description; Region: UvrD_C_2; pfam13538 399741012641 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 399741012642 protease3; Provisional; Region: PRK15101 399741012643 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 399741012644 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 399741012645 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 399741012646 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 399741012647 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 399741012648 hypothetical protein; Provisional; Region: PRK10332 399741012649 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 399741012650 Protein of unknown function (DUF2509); Region: DUF2509; pfam10713 399741012651 hypothetical protein; Provisional; Region: PRK10557 399741012652 hypothetical protein; Provisional; Region: PRK10506 399741012653 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 399741012654 thymidylate synthase; Reviewed; Region: thyA; PRK01827 399741012655 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 399741012656 dimerization interface [polypeptide binding]; other site 399741012657 active site 399741012658 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 399741012659 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 399741012660 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 399741012661 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 399741012662 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 399741012663 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 399741012664 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 399741012665 putative active site [active] 399741012666 Ap4A binding site [chemical binding]; other site 399741012667 nudix motif; other site 399741012668 putative metal binding site [ion binding]; other site 399741012669 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 399741012670 putative DNA-binding cleft [nucleotide binding]; other site 399741012671 putative DNA clevage site; other site 399741012672 molecular lever; other site 399741012673 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 399741012674 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 399741012675 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 399741012676 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 399741012677 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 399741012678 active site 399741012679 catalytic tetrad [active] 399741012680 lysophospholipid transporter LplT; Provisional; Region: PRK11195 399741012681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741012682 putative substrate translocation pore; other site 399741012683 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 399741012684 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 399741012685 putative acyl-acceptor binding pocket; other site 399741012686 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 399741012687 acyl-activating enzyme (AAE) consensus motif; other site 399741012688 putative AMP binding site [chemical binding]; other site 399741012689 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 399741012690 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 399741012691 molybdopterin cofactor binding site [chemical binding]; other site 399741012692 substrate binding site [chemical binding]; other site 399741012693 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 399741012694 molybdopterin cofactor binding site; other site 399741012695 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 399741012696 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741012697 DNA binding site [nucleotide binding] 399741012698 domain linker motif; other site 399741012699 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 399741012700 dimerization interface (closed form) [polypeptide binding]; other site 399741012701 ligand binding site [chemical binding]; other site 399741012702 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741012703 Coenzyme A binding pocket [chemical binding]; other site 399741012704 Transcriptional regulators [Transcription]; Region: PurR; COG1609 399741012705 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741012706 DNA binding site [nucleotide binding] 399741012707 domain linker motif; other site 399741012708 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 399741012709 dimerization interface (closed form) [polypeptide binding]; other site 399741012710 ligand binding site [chemical binding]; other site 399741012711 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741012712 sequence-specific DNA binding site [nucleotide binding]; other site 399741012713 salt bridge; other site 399741012714 diaminopimelate decarboxylase; Provisional; Region: PRK11165 399741012715 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 399741012716 active site 399741012717 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 399741012718 substrate binding site [chemical binding]; other site 399741012719 catalytic residues [active] 399741012720 dimer interface [polypeptide binding]; other site 399741012721 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 399741012722 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741012723 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741012724 dimerization interface [polypeptide binding]; other site 399741012725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741012726 putative substrate translocation pore; other site 399741012727 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741012728 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741012729 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741012730 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 399741012731 putative effector binding pocket; other site 399741012732 dimerization interface [polypeptide binding]; other site 399741012733 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 399741012734 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 399741012735 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 399741012736 catalytic residues [active] 399741012737 Tetratricopeptide repeat; Region: TPR_12; pfam13424 399741012738 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 399741012739 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 399741012740 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 399741012741 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 399741012742 active pocket/dimerization site; other site 399741012743 active site 399741012744 phosphorylation site [posttranslational modification] 399741012745 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 399741012746 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 399741012747 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 399741012748 active site 399741012749 phosphorylation site [posttranslational modification] 399741012750 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 399741012751 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 399741012752 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 399741012753 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 399741012754 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 399741012755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741012756 putative substrate translocation pore; other site 399741012757 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 399741012758 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 399741012759 Walker A/P-loop; other site 399741012760 ATP binding site [chemical binding]; other site 399741012761 Q-loop/lid; other site 399741012762 ABC transporter signature motif; other site 399741012763 Walker B; other site 399741012764 D-loop; other site 399741012765 H-loop/switch region; other site 399741012766 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741012767 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741012768 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 399741012769 putative effector binding pocket; other site 399741012770 dimerization interface [polypeptide binding]; other site 399741012771 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 399741012772 L-lactate permease; Region: Lactate_perm; cl00701 399741012773 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 399741012774 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 399741012775 phosphate binding site [ion binding]; other site 399741012776 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741012777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741012778 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 399741012779 putative effector binding pocket; other site 399741012780 dimerization interface [polypeptide binding]; other site 399741012781 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 399741012782 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 399741012783 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 399741012784 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 399741012785 Walker A/P-loop; other site 399741012786 ATP binding site [chemical binding]; other site 399741012787 Q-loop/lid; other site 399741012788 ABC transporter signature motif; other site 399741012789 Walker B; other site 399741012790 D-loop; other site 399741012791 H-loop/switch region; other site 399741012792 acid-resistance membrane protein; Provisional; Region: PRK10209 399741012793 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 399741012794 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 399741012795 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 399741012796 HSP70 interaction site [polypeptide binding]; other site 399741012797 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 399741012798 substrate binding site [polypeptide binding]; other site 399741012799 dimer interface [polypeptide binding]; other site 399741012800 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 399741012801 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 399741012802 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 399741012803 DNA-binding site [nucleotide binding]; DNA binding site 399741012804 RNA-binding motif; other site 399741012805 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 399741012806 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 399741012807 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741012808 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741012809 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 399741012810 putative effector binding pocket; other site 399741012811 dimerization interface [polypeptide binding]; other site 399741012812 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 399741012813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 399741012814 NAD(P) binding site [chemical binding]; other site 399741012815 active site 399741012816 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 399741012817 classical (c) SDRs; Region: SDR_c; cd05233 399741012818 NAD(P) binding site [chemical binding]; other site 399741012819 active site 399741012820 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 399741012821 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 399741012822 NAD(P) binding site [chemical binding]; other site 399741012823 catalytic residues [active] 399741012824 Biofilm formation and stress response factor; Region: BsmA; cl01794 399741012825 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 399741012826 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 399741012827 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 399741012828 catalytic residue [active] 399741012829 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 399741012830 structural protein; Region: PHA01972 399741012831 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741012832 putative lysin; Region: PHA00658 399741012833 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 399741012834 N-acetyl-D-glucosamine binding site [chemical binding]; other site 399741012835 catalytic residue [active] 399741012836 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 399741012837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 399741012838 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 399741012839 active site 399741012840 metal binding site [ion binding]; metal-binding site 399741012841 interdomain interaction site; other site 399741012842 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 399741012843 Ash protein family; Region: Phage_ASH; pfam10554 399741012844 AntA/AntB antirepressor; Region: AntA; pfam08346 399741012845 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 399741012846 integrase; Provisional; Region: PRK09692 399741012847 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 399741012848 active site 399741012849 Int/Topo IB signature motif; other site 399741012850 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 399741012851 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 399741012852 dimer interface [polypeptide binding]; other site 399741012853 putative anticodon binding site; other site 399741012854 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 399741012855 motif 1; other site 399741012856 active site 399741012857 motif 2; other site 399741012858 motif 3; other site 399741012859 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 399741012860 DHH family; Region: DHH; pfam01368 399741012861 DHHA1 domain; Region: DHHA1; pfam02272 399741012862 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 399741012863 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 399741012864 dimerization domain [polypeptide binding]; other site 399741012865 dimer interface [polypeptide binding]; other site 399741012866 catalytic residues [active] 399741012867 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 399741012868 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 399741012869 active site 399741012870 Int/Topo IB signature motif; other site 399741012871 flavodoxin FldB; Provisional; Region: PRK12359 399741012872 Inner membrane protein CreD; Region: CreD; pfam06123 399741012873 sensory histidine kinase CreC; Provisional; Region: PRK11100 399741012874 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 399741012875 dimerization interface [polypeptide binding]; other site 399741012876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741012877 dimer interface [polypeptide binding]; other site 399741012878 phosphorylation site [posttranslational modification] 399741012879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741012880 ATP binding site [chemical binding]; other site 399741012881 Mg2+ binding site [ion binding]; other site 399741012882 G-X-G motif; other site 399741012883 DNA-binding response regulator CreB; Provisional; Region: PRK11083 399741012884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741012885 active site 399741012886 phosphorylation site [posttranslational modification] 399741012887 intermolecular recognition site; other site 399741012888 dimerization interface [polypeptide binding]; other site 399741012889 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741012890 DNA binding site [nucleotide binding] 399741012891 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 399741012892 hypothetical protein; Provisional; Region: PRK10878 399741012893 putative global regulator; Reviewed; Region: PRK09559 399741012894 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 399741012895 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 399741012896 hemolysin; Provisional; Region: PRK15087 399741012897 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 399741012898 HD domain; Region: HD_3; pfam13023 399741012899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741012900 metabolite-proton symporter; Region: 2A0106; TIGR00883 399741012901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741012902 amidase; Provisional; Region: PRK07056 399741012903 Amidase; Region: Amidase; cl11426 399741012904 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 399741012905 Transcriptional regulators [Transcription]; Region: GntR; COG1802 399741012906 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741012907 DNA-binding site [nucleotide binding]; DNA binding site 399741012908 FCD domain; Region: FCD; pfam07729 399741012909 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 399741012910 Protein of unknown function (DUF497); Region: DUF497; pfam04365 399741012911 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 399741012912 classical (c) SDRs; Region: SDR_c; cd05233 399741012913 NAD(P) binding site [chemical binding]; other site 399741012914 active site 399741012915 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 399741012916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741012917 active site 399741012918 phosphorylation site [posttranslational modification] 399741012919 intermolecular recognition site; other site 399741012920 dimerization interface [polypeptide binding]; other site 399741012921 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741012922 DNA binding site [nucleotide binding] 399741012923 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 399741012924 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 399741012925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741012926 dimer interface [polypeptide binding]; other site 399741012927 phosphorylation site [posttranslational modification] 399741012928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741012929 ATP binding site [chemical binding]; other site 399741012930 Mg2+ binding site [ion binding]; other site 399741012931 G-X-G motif; other site 399741012932 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 399741012933 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 399741012934 NAD(P) binding site [chemical binding]; other site 399741012935 Autotransporter beta-domain; Region: Autotransporter; smart00869 399741012936 glycine dehydrogenase; Provisional; Region: PRK05367 399741012937 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 399741012938 tetramer interface [polypeptide binding]; other site 399741012939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741012940 catalytic residue [active] 399741012941 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 399741012942 tetramer interface [polypeptide binding]; other site 399741012943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741012944 catalytic residue [active] 399741012945 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 399741012946 lipoyl attachment site [posttranslational modification]; other site 399741012947 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 399741012948 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 399741012949 oxidoreductase; Provisional; Region: PRK08013 399741012950 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 399741012951 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 399741012952 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 399741012953 proline aminopeptidase P II; Provisional; Region: PRK10879 399741012954 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 399741012955 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 399741012956 active site 399741012957 hypothetical protein; Reviewed; Region: PRK01736 399741012958 Z-ring-associated protein; Provisional; Region: PRK10972 399741012959 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 399741012960 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 399741012961 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 399741012962 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 399741012963 ligand binding site [chemical binding]; other site 399741012964 NAD binding site [chemical binding]; other site 399741012965 tetramer interface [polypeptide binding]; other site 399741012966 catalytic site [active] 399741012967 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 399741012968 L-serine binding site [chemical binding]; other site 399741012969 ACT domain interface; other site 399741012970 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 399741012971 tetramer (dimer of dimers) interface [polypeptide binding]; other site 399741012972 active site 399741012973 dimer interface [polypeptide binding]; other site 399741012974 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 399741012975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741012976 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 399741012977 putative dimerization interface [polypeptide binding]; other site 399741012978 Uncharacterized conserved protein [Function unknown]; Region: COG2968 399741012979 oxidative stress defense protein; Provisional; Region: PRK11087 399741012980 arginine exporter protein; Provisional; Region: PRK09304 399741012981 Transcriptional regulator [Transcription]; Region: IclR; COG1414 399741012982 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 399741012983 Bacterial transcriptional regulator; Region: IclR; pfam01614 399741012984 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 399741012985 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 399741012986 Walker A/P-loop; other site 399741012987 ATP binding site [chemical binding]; other site 399741012988 Q-loop/lid; other site 399741012989 ABC transporter signature motif; other site 399741012990 Walker B; other site 399741012991 D-loop; other site 399741012992 H-loop/switch region; other site 399741012993 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 399741012994 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 399741012995 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 399741012996 TM-ABC transporter signature motif; other site 399741012997 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315 399741012998 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 399741012999 putative ligand binding site [chemical binding]; other site 399741013000 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 399741013001 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 399741013002 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 399741013003 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 399741013004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741013005 D-galactonate transporter; Region: 2A0114; TIGR00893 399741013006 putative substrate translocation pore; other site 399741013007 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 399741013008 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 399741013009 putative N- and C-terminal domain interface [polypeptide binding]; other site 399741013010 putative active site [active] 399741013011 MgATP binding site [chemical binding]; other site 399741013012 catalytic site [active] 399741013013 metal binding site [ion binding]; metal-binding site 399741013014 putative xylulose binding site [chemical binding]; other site 399741013015 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 399741013016 active site 399741013017 dimer interface [polypeptide binding]; other site 399741013018 magnesium binding site [ion binding]; other site 399741013019 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 399741013020 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 399741013021 AP (apurinic/apyrimidinic) site pocket; other site 399741013022 DNA interaction; other site 399741013023 Metal-binding active site; metal-binding site 399741013024 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 399741013025 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 399741013026 intersubunit interface [polypeptide binding]; other site 399741013027 active site 399741013028 Zn2+ binding site [ion binding]; other site 399741013029 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 399741013030 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 399741013031 active site 399741013032 benzoate transport; Region: 2A0115; TIGR00895 399741013033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741013034 putative substrate translocation pore; other site 399741013035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741013036 mechanosensitive channel MscS; Provisional; Region: PRK10334 399741013037 Mechanosensitive ion channel; Region: MS_channel; pfam00924 399741013038 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 399741013039 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 399741013040 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 399741013041 active site 399741013042 intersubunit interface [polypeptide binding]; other site 399741013043 zinc binding site [ion binding]; other site 399741013044 Na+ binding site [ion binding]; other site 399741013045 Phosphoglycerate kinase; Region: PGK; pfam00162 399741013046 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 399741013047 substrate binding site [chemical binding]; other site 399741013048 hinge regions; other site 399741013049 ADP binding site [chemical binding]; other site 399741013050 catalytic site [active] 399741013051 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 399741013052 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 399741013053 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 399741013054 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 399741013055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741013056 Walker A/P-loop; other site 399741013057 ATP binding site [chemical binding]; other site 399741013058 Q-loop/lid; other site 399741013059 ABC transporter signature motif; other site 399741013060 Walker B; other site 399741013061 D-loop; other site 399741013062 H-loop/switch region; other site 399741013063 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 399741013064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741013065 dimer interface [polypeptide binding]; other site 399741013066 conserved gate region; other site 399741013067 ABC-ATPase subunit interface; other site 399741013068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741013069 dimer interface [polypeptide binding]; other site 399741013070 conserved gate region; other site 399741013071 putative PBP binding loops; other site 399741013072 ABC-ATPase subunit interface; other site 399741013073 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 399741013074 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 399741013075 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 399741013076 dimer interface [polypeptide binding]; other site 399741013077 putative tRNA-binding site [nucleotide binding]; other site 399741013078 Biofilm formation and stress response factor; Region: BsmA; pfam10014 399741013079 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 399741013080 transketolase; Reviewed; Region: PRK12753 399741013081 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 399741013082 TPP-binding site [chemical binding]; other site 399741013083 dimer interface [polypeptide binding]; other site 399741013084 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 399741013085 PYR/PP interface [polypeptide binding]; other site 399741013086 dimer interface [polypeptide binding]; other site 399741013087 TPP binding site [chemical binding]; other site 399741013088 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 399741013089 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 399741013090 hypothetical protein; Provisional; Region: PRK07064 399741013091 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 399741013092 PYR/PP interface [polypeptide binding]; other site 399741013093 dimer interface [polypeptide binding]; other site 399741013094 TPP binding site [chemical binding]; other site 399741013095 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 399741013096 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 399741013097 TPP-binding site [chemical binding]; other site 399741013098 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 399741013099 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 399741013100 NAD(P) binding site [chemical binding]; other site 399741013101 catalytic residues [active] 399741013102 L-aspartate dehydrogenase; Provisional; Region: PRK13303 399741013103 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 399741013104 Domain of unknown function DUF108; Region: DUF108; pfam01958 399741013105 short chain dehydrogenase; Provisional; Region: PRK07062 399741013106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 399741013107 NAD(P) binding site [chemical binding]; other site 399741013108 active site 399741013109 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 399741013110 Cupin domain; Region: Cupin_2; pfam07883 399741013111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741013112 D-galactonate transporter; Region: 2A0114; TIGR00893 399741013113 putative substrate translocation pore; other site 399741013114 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 399741013115 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 399741013116 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 399741013117 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 399741013118 putative active site [active] 399741013119 putative metal binding site [ion binding]; other site 399741013120 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 399741013121 Transcriptional regulator [Transcription]; Region: IclR; COG1414 399741013122 Bacterial transcriptional regulator; Region: IclR; pfam01614 399741013123 short chain dehydrogenase; Provisional; Region: PRK12939 399741013124 classical (c) SDRs; Region: SDR_c; cd05233 399741013125 NAD(P) binding site [chemical binding]; other site 399741013126 active site 399741013127 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 399741013128 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 399741013129 [2Fe-2S] cluster binding site [ion binding]; other site 399741013130 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 399741013131 hydrophobic ligand binding site; other site 399741013132 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 399741013133 [2Fe-2S] cluster binding site [ion binding]; other site 399741013134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741013135 D-galactonate transporter; Region: 2A0114; TIGR00893 399741013136 putative substrate translocation pore; other site 399741013137 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 399741013138 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 399741013139 RNA binding surface [nucleotide binding]; other site 399741013140 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 399741013141 probable active site [active] 399741013142 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 399741013143 agmatinase; Region: agmatinase; TIGR01230 399741013144 oligomer interface [polypeptide binding]; other site 399741013145 putative active site [active] 399741013146 Mn binding site [ion binding]; other site 399741013147 arginine decarboxylase; Provisional; Region: PRK05354 399741013148 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 399741013149 dimer interface [polypeptide binding]; other site 399741013150 active site 399741013151 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 399741013152 catalytic residues [active] 399741013153 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 399741013154 S-adenosylmethionine synthetase; Validated; Region: PRK05250 399741013155 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 399741013156 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 399741013157 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 399741013158 Hok/gef family; Region: HOK_GEF; pfam01848 399741013159 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 399741013160 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 399741013161 ABC-ATPase subunit interface; other site 399741013162 dimer interface [polypeptide binding]; other site 399741013163 putative PBP binding regions; other site 399741013164 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 399741013165 ABC-ATPase subunit interface; other site 399741013166 dimer interface [polypeptide binding]; other site 399741013167 putative PBP binding regions; other site 399741013168 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 399741013169 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 399741013170 siderophore binding site; other site 399741013171 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 399741013172 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 399741013173 Walker A/P-loop; other site 399741013174 ATP binding site [chemical binding]; other site 399741013175 Q-loop/lid; other site 399741013176 ABC transporter signature motif; other site 399741013177 Walker B; other site 399741013178 D-loop; other site 399741013179 H-loop/switch region; other site 399741013180 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 399741013181 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 399741013182 N-terminal plug; other site 399741013183 ligand-binding site [chemical binding]; other site 399741013184 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 399741013185 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 399741013186 Transglycosylase; Region: Transgly; pfam00912 399741013187 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 399741013188 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 399741013189 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 399741013190 ATP binding site [chemical binding]; other site 399741013191 putative Mg++ binding site [ion binding]; other site 399741013192 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 399741013193 nucleotide binding region [chemical binding]; other site 399741013194 ATP-binding site [chemical binding]; other site 399741013195 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 399741013196 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 399741013197 2'-5' RNA ligase; Provisional; Region: PRK15124 399741013198 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 399741013199 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 399741013200 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 399741013201 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 399741013202 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 399741013203 active site 399741013204 nucleotide binding site [chemical binding]; other site 399741013205 HIGH motif; other site 399741013206 KMSKS motif; other site 399741013207 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 399741013208 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 399741013209 active site 399741013210 NTP binding site [chemical binding]; other site 399741013211 metal binding triad [ion binding]; metal-binding site 399741013212 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 399741013213 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 399741013214 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 399741013215 catalytic center binding site [active] 399741013216 ATP binding site [chemical binding]; other site 399741013217 sensor protein QseC; Provisional; Region: PRK10337 399741013218 HAMP domain; Region: HAMP; pfam00672 399741013219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741013220 dimer interface [polypeptide binding]; other site 399741013221 phosphorylation site [posttranslational modification] 399741013222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741013223 ATP binding site [chemical binding]; other site 399741013224 Mg2+ binding site [ion binding]; other site 399741013225 G-X-G motif; other site 399741013226 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 399741013227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741013228 active site 399741013229 phosphorylation site [posttranslational modification] 399741013230 intermolecular recognition site; other site 399741013231 dimerization interface [polypeptide binding]; other site 399741013232 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741013233 DNA binding site [nucleotide binding] 399741013234 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 399741013235 oligomerization interface [polypeptide binding]; other site 399741013236 active site 399741013237 metal binding site [ion binding]; metal-binding site 399741013238 Pantoate-beta-alanine ligase; Region: PanC; cd00560 399741013239 pantoate--beta-alanine ligase; Region: panC; TIGR00018 399741013240 active site 399741013241 ATP-binding site [chemical binding]; other site 399741013242 pantoate-binding site; other site 399741013243 HXXH motif; other site 399741013244 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 399741013245 tetramerization interface [polypeptide binding]; other site 399741013246 active site 399741013247 Bacterial SH3 domain; Region: SH3_3; cl17532 399741013248 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 399741013249 putative active site [active] 399741013250 putative metal binding site [ion binding]; other site 399741013251 inner membrane transport permease; Provisional; Region: PRK15066 399741013252 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 399741013253 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 399741013254 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 399741013255 Walker A/P-loop; other site 399741013256 ATP binding site [chemical binding]; other site 399741013257 Q-loop/lid; other site 399741013258 ABC transporter signature motif; other site 399741013259 Walker B; other site 399741013260 D-loop; other site 399741013261 H-loop/switch region; other site 399741013262 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 399741013263 active site clefts [active] 399741013264 zinc binding site [ion binding]; other site 399741013265 dimer interface [polypeptide binding]; other site 399741013266 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 399741013267 active site 399741013268 multicopper oxidase; Provisional; Region: PRK10965 399741013269 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 399741013270 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 399741013271 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 399741013272 spermidine synthase; Provisional; Region: PRK00811 399741013273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741013274 S-adenosylmethionine binding site [chemical binding]; other site 399741013275 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 399741013276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 399741013277 DNA-binding site [nucleotide binding]; DNA binding site 399741013278 PRD domain; Region: PRD; pfam00874 399741013279 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 399741013280 dimer interface [polypeptide binding]; other site 399741013281 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 399741013282 active site 399741013283 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 399741013284 substrate binding site [chemical binding]; other site 399741013285 catalytic residue [active] 399741013286 putative mutase; Provisional; Region: PRK12383 399741013287 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 399741013288 hypothetical protein; Provisional; Region: PRK05248 399741013289 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 399741013290 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 399741013291 substrate binding site [chemical binding]; other site 399741013292 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 399741013293 substrate binding site [chemical binding]; other site 399741013294 ligand binding site [chemical binding]; other site 399741013295 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 399741013296 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 399741013297 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 399741013298 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 399741013299 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 399741013300 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 399741013301 E3 interaction surface; other site 399741013302 lipoyl attachment site [posttranslational modification]; other site 399741013303 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 399741013304 E3 interaction surface; other site 399741013305 lipoyl attachment site [posttranslational modification]; other site 399741013306 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 399741013307 E3 interaction surface; other site 399741013308 lipoyl attachment site [posttranslational modification]; other site 399741013309 e3 binding domain; Region: E3_binding; pfam02817 399741013310 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 399741013311 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 399741013312 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 399741013313 dimer interface [polypeptide binding]; other site 399741013314 TPP-binding site [chemical binding]; other site 399741013315 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 399741013316 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741013317 DNA-binding site [nucleotide binding]; DNA binding site 399741013318 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 399741013319 aromatic amino acid transporter; Provisional; Region: PRK10238 399741013320 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 399741013321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741013322 putative substrate translocation pore; other site 399741013323 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 399741013324 active site 399741013325 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 399741013326 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 399741013327 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 399741013328 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 399741013329 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 399741013330 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 399741013331 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 399741013332 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 399741013333 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 399741013334 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 399741013335 Ligand binding site; other site 399741013336 metal-binding site 399741013337 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 399741013338 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 399741013339 XdhC Rossmann domain; Region: XdhC_C; pfam13478 399741013340 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 399741013341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741013342 fumarate hydratase; Provisional; Region: PRK15389 399741013343 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 399741013344 Fumarase C-terminus; Region: Fumerase_C; pfam05683 399741013345 hypothetical protein; Provisional; Region: PRK04860 399741013346 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 399741013347 DNA-specific endonuclease I; Provisional; Region: PRK15137 399741013348 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 399741013349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 399741013350 RNA methyltransferase, RsmE family; Region: TIGR00046 399741013351 glutathione synthetase; Provisional; Region: PRK05246 399741013352 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 399741013353 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 399741013354 hypothetical protein; Validated; Region: PRK00228 399741013355 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 399741013356 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 399741013357 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 399741013358 Walker A motif; other site 399741013359 ATP binding site [chemical binding]; other site 399741013360 Walker B motif; other site 399741013361 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 399741013362 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 399741013363 catalytic residue [active] 399741013364 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 399741013365 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 399741013366 YGGT family; Region: YGGT; pfam02325 399741013367 YGGT family; Region: YGGT; pfam02325 399741013368 hypothetical protein; Validated; Region: PRK05090 399741013369 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 399741013370 active site 399741013371 dimerization interface [polypeptide binding]; other site 399741013372 HemN family oxidoreductase; Provisional; Region: PRK05660 399741013373 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 399741013374 FeS/SAM binding site; other site 399741013375 HemN C-terminal domain; Region: HemN_C; pfam06969 399741013376 Domain of unknown function DUF29; Region: DUF29; pfam01724 399741013377 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 399741013378 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 399741013379 hypothetical protein; Provisional; Region: PRK10626 399741013380 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 399741013381 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 399741013382 glutaminase; Provisional; Region: PRK00971 399741013383 hypothetical protein; Provisional; Region: PRK11702 399741013384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741013385 S-adenosylmethionine binding site [chemical binding]; other site 399741013386 adenine DNA glycosylase; Provisional; Region: PRK10880 399741013387 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 399741013388 minor groove reading motif; other site 399741013389 helix-hairpin-helix signature motif; other site 399741013390 substrate binding pocket [chemical binding]; other site 399741013391 active site 399741013392 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 399741013393 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 399741013394 DNA binding and oxoG recognition site [nucleotide binding] 399741013395 oxidative damage protection protein; Provisional; Region: PRK05408 399741013396 murein transglycosylase C; Provisional; Region: mltC; PRK11671 399741013397 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 399741013398 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 399741013399 N-acetyl-D-glucosamine binding site [chemical binding]; other site 399741013400 catalytic residue [active] 399741013401 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 399741013402 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 399741013403 metal binding site [ion binding]; metal-binding site 399741013404 active site 399741013405 I-site; other site 399741013406 ornithine decarboxylase; Provisional; Region: PRK13578 399741013407 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 399741013408 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 399741013409 homodimer interface [polypeptide binding]; other site 399741013410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741013411 catalytic residue [active] 399741013412 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 399741013413 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 399741013414 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 399741013415 active site 399741013416 catalytic residues [active] 399741013417 DNA binding site [nucleotide binding] 399741013418 Int/Topo IB signature motif; other site 399741013419 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 399741013420 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 399741013421 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 399741013422 Family description; Region: UvrD_C_2; pfam13538 399741013423 BetR domain; Region: BetR; pfam08667 399741013424 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 399741013425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741013426 active site 399741013427 phosphorylation site [posttranslational modification] 399741013428 intermolecular recognition site; other site 399741013429 dimerization interface [polypeptide binding]; other site 399741013430 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 399741013431 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 399741013432 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 399741013433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741013434 dimer interface [polypeptide binding]; other site 399741013435 phosphorylation site [posttranslational modification] 399741013436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741013437 ATP binding site [chemical binding]; other site 399741013438 Mg2+ binding site [ion binding]; other site 399741013439 G-X-G motif; other site 399741013440 Response regulator receiver domain; Region: Response_reg; pfam00072 399741013441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741013442 active site 399741013443 phosphorylation site [posttranslational modification] 399741013444 intermolecular recognition site; other site 399741013445 dimerization interface [polypeptide binding]; other site 399741013446 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 399741013447 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 399741013448 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 399741013449 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 399741013450 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 399741013451 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 399741013452 Integrase; Region: Integrase_1; pfam12835 399741013453 Y-family of DNA polymerases; Region: PolY; cl12025 399741013454 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 399741013455 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 399741013456 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 399741013457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741013458 motif II; other site 399741013459 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741013460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741013461 homodimer interface [polypeptide binding]; other site 399741013462 catalytic residue [active] 399741013463 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 399741013464 hypothetical protein; Provisional; Region: PRK07206 399741013465 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 399741013466 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741013467 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 399741013468 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 399741013469 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 399741013470 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 399741013471 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 399741013472 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 399741013473 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 399741013474 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 399741013475 haemagglutination activity domain; Region: Haemagg_act; pfam05860 399741013476 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 399741013477 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 399741013478 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 399741013479 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 399741013480 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 399741013481 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 399741013482 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 399741013483 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 399741013484 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 399741013485 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 399741013486 Transposase; Region: HTH_Tnp_1; pfam01527 399741013487 HTH-like domain; Region: HTH_21; pfam13276 399741013488 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 399741013489 Integrase core domain; Region: rve; pfam00665 399741013490 Integrase core domain; Region: rve_3; pfam13683 399741013491 HsdM N-terminal domain; Region: HsdM_N; pfam12161 399741013492 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 399741013493 Methyltransferase domain; Region: Methyltransf_26; pfam13659 399741013494 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 399741013495 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 399741013496 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 399741013497 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 399741013498 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 399741013499 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 399741013500 ATP binding site [chemical binding]; other site 399741013501 putative Mg++ binding site [ion binding]; other site 399741013502 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cl07672 399741013503 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 399741013504 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 399741013505 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 399741013506 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 399741013507 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 399741013508 Protein of unknown function (DUF2895); Region: DUF2895; pfam11444 399741013509 conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750 399741013510 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 399741013511 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 399741013512 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 399741013513 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 399741013514 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 399741013515 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 399741013516 Restriction endonuclease; Region: Mrr_cat; pfam04471 399741013517 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 399741013518 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 399741013519 N-acetyl-D-glucosamine binding site [chemical binding]; other site 399741013520 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 399741013521 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 399741013522 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 399741013523 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 399741013524 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 399741013525 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 399741013526 dimer interface [polypeptide binding]; other site 399741013527 ssDNA binding site [nucleotide binding]; other site 399741013528 tetramer (dimer of dimers) interface [polypeptide binding]; other site 399741013529 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 399741013530 DNA topoisomerase III; Provisional; Region: PRK07726 399741013531 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 399741013532 active site 399741013533 putative interdomain interaction site [polypeptide binding]; other site 399741013534 putative metal-binding site [ion binding]; other site 399741013535 putative nucleotide binding site [chemical binding]; other site 399741013536 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 399741013537 domain I; other site 399741013538 DNA binding groove [nucleotide binding] 399741013539 phosphate binding site [ion binding]; other site 399741013540 domain II; other site 399741013541 domain III; other site 399741013542 nucleotide binding site [chemical binding]; other site 399741013543 catalytic site [active] 399741013544 domain IV; other site 399741013545 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 399741013546 Helix-turn-helix domain; Region: HTH_36; pfam13730 399741013547 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 399741013548 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 399741013549 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 399741013550 replicative DNA helicase; Region: DnaB; TIGR00665 399741013551 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 399741013552 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 399741013553 Walker A motif; other site 399741013554 ATP binding site [chemical binding]; other site 399741013555 Walker B motif; other site 399741013556 DNA binding loops [nucleotide binding] 399741013557 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 399741013558 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 399741013559 P-loop; other site 399741013560 Magnesium ion binding site [ion binding]; other site 399741013561 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 399741013562 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 399741013563 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 399741013564 active site 399741013565 catalytic residues [active] 399741013566 DNA binding site [nucleotide binding] 399741013567 Int/Topo IB signature motif; other site 399741013568 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 399741013569 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 399741013570 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 399741013571 classical (c) SDRs; Region: SDR_c; cd05233 399741013572 NAD(P) binding site [chemical binding]; other site 399741013573 active site 399741013574 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 399741013575 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 399741013576 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 399741013577 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 399741013578 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 399741013579 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 399741013580 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741013581 non-specific DNA binding site [nucleotide binding]; other site 399741013582 salt bridge; other site 399741013583 sequence-specific DNA binding site [nucleotide binding]; other site 399741013584 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 399741013585 Integrase; Region: Integrase_1; pfam12835 399741013586 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 399741013587 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 399741013588 conserved cys residue [active] 399741013589 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 399741013590 DNA binding site [nucleotide binding] 399741013591 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 399741013592 Fimbrial protein; Region: Fimbrial; pfam00419 399741013593 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 399741013594 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 399741013595 active site 399741013596 NTP binding site [chemical binding]; other site 399741013597 nucleic acid binding site [nucleotide binding]; other site 399741013598 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 399741013599 Fimbrial protein; Region: Fimbrial; pfam00419 399741013600 Fimbrial protein; Region: Fimbrial; pfam00419 399741013601 Fimbrial protein; Region: Fimbrial; pfam00419 399741013602 Fimbrial protein; Region: Fimbrial; pfam00419 399741013603 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 399741013604 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 399741013605 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 399741013606 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 399741013607 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 399741013608 PapC N-terminal domain; Region: PapC_N; pfam13954 399741013609 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 399741013610 PapC C-terminal domain; Region: PapC_C; pfam13953 399741013611 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 399741013612 Fimbrial protein; Region: Fimbrial; cl01416 399741013613 Fimbrial protein; Region: Fimbrial; cl01416 399741013614 FaeA-like protein; Region: FaeA; pfam04703 399741013615 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 399741013616 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741013617 DNA binding residues [nucleotide binding] 399741013618 dimerization interface [polypeptide binding]; other site 399741013619 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 399741013620 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 399741013621 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 399741013622 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 399741013623 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 399741013624 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 399741013625 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 399741013626 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 399741013627 PapC N-terminal domain; Region: PapC_N; pfam13954 399741013628 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 399741013629 PapC C-terminal domain; Region: PapC_C; pfam13953 399741013630 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 399741013631 Fimbrial protein; Region: Fimbrial; pfam00419 399741013632 putative transposase OrfB; Reviewed; Region: PHA02517 399741013633 HTH-like domain; Region: HTH_21; pfam13276 399741013634 Integrase core domain; Region: rve; pfam00665 399741013635 Integrase core domain; Region: rve_3; pfam13683 399741013636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 399741013637 Transposase; Region: HTH_Tnp_1; pfam01527 399741013638 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 399741013639 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 399741013640 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 399741013641 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 399741013642 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741013643 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741013644 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 399741013645 putative effector binding pocket; other site 399741013646 putative dimerization interface [polypeptide binding]; other site 399741013647 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 399741013648 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 399741013649 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 399741013650 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 399741013651 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 399741013652 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 399741013653 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 399741013654 Protein of unknown function (DUF2895); Region: DUF2895; pfam11444 399741013655 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 399741013656 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 399741013657 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 399741013658 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 399741013659 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 399741013660 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 399741013661 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 399741013662 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 399741013663 Restriction endonuclease; Region: Mrr_cat; pfam04471 399741013664 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 399741013665 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 399741013666 N-acetyl-D-glucosamine binding site [chemical binding]; other site 399741013667 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 399741013668 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 399741013669 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 399741013670 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 399741013671 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 399741013672 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 399741013673 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 399741013674 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 399741013675 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 399741013676 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 399741013677 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 399741013678 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 399741013679 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 399741013680 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 399741013681 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 399741013682 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 399741013683 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 399741013684 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 399741013685 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 399741013686 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 399741013687 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741013688 Coenzyme A binding pocket [chemical binding]; other site 399741013689 PAS fold; Region: PAS_4; pfam08448 399741013690 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 399741013691 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741013692 DNA binding residues [nucleotide binding] 399741013693 dimerization interface [polypeptide binding]; other site 399741013694 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 399741013695 Na binding site [ion binding]; other site 399741013696 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741013697 non-specific DNA binding site [nucleotide binding]; other site 399741013698 salt bridge; other site 399741013699 sequence-specific DNA binding site [nucleotide binding]; other site 399741013700 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 399741013701 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 399741013702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 399741013703 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 399741013704 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 399741013705 Phosphoesterase family; Region: Phosphoesterase; pfam04185 399741013706 Domain of unknown function (DUF756); Region: DUF756; pfam05506 399741013707 Domain of unknown function (DUF756); Region: DUF756; pfam05506 399741013708 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 399741013709 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741013710 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741013711 dimerization interface [polypeptide binding]; other site 399741013712 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 399741013713 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 399741013714 putative metal binding site [ion binding]; other site 399741013715 dimer interface [polypeptide binding]; other site 399741013716 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 399741013717 amidohydrolase; Region: amidohydrolases; TIGR01891 399741013718 putative metal binding site [ion binding]; other site 399741013719 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 399741013720 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 399741013721 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 399741013722 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 399741013723 putative substrate binding site [chemical binding]; other site 399741013724 putative ATP binding site [chemical binding]; other site 399741013725 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 399741013726 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 399741013727 active site turn [active] 399741013728 phosphorylation site [posttranslational modification] 399741013729 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 399741013730 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 399741013731 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 399741013732 substrate binding [chemical binding]; other site 399741013733 active site 399741013734 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 399741013735 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 399741013736 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741013737 DNA binding site [nucleotide binding] 399741013738 domain linker motif; other site 399741013739 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 399741013740 dimerization interface [polypeptide binding]; other site 399741013741 ligand binding site [chemical binding]; other site 399741013742 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 399741013743 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 399741013744 biopolymer transport protein ExbD; Provisional; Region: PRK11267 399741013745 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 399741013746 biopolymer transport protein ExbB; Provisional; Region: PRK10414 399741013747 cystathionine beta-lyase; Provisional; Region: PRK08114 399741013748 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 399741013749 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 399741013750 catalytic residue [active] 399741013751 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 399741013752 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 399741013753 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 399741013754 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 399741013755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741013756 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741013757 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 399741013758 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 399741013759 dimer interface [polypeptide binding]; other site 399741013760 active site 399741013761 metal binding site [ion binding]; metal-binding site 399741013762 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 399741013763 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 399741013764 active site 399741013765 catalytic tetrad [active] 399741013766 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 399741013767 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 399741013768 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 399741013769 molybdopterin cofactor binding site [chemical binding]; other site 399741013770 substrate binding site [chemical binding]; other site 399741013771 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 399741013772 molybdopterin cofactor binding site; other site 399741013773 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 399741013774 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 399741013775 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 399741013776 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741013777 DNA-binding site [nucleotide binding]; DNA binding site 399741013778 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741013779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741013780 homodimer interface [polypeptide binding]; other site 399741013781 catalytic residue [active] 399741013782 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 399741013783 beta-galactosidase; Region: BGL; TIGR03356 399741013784 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 399741013785 methionine cluster; other site 399741013786 active site 399741013787 phosphorylation site [posttranslational modification] 399741013788 metal binding site [ion binding]; metal-binding site 399741013789 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 399741013790 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 399741013791 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 399741013792 active site 399741013793 P-loop; other site 399741013794 phosphorylation site [posttranslational modification] 399741013795 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 399741013796 active site 399741013797 catalytic residues [active] 399741013798 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 399741013799 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 399741013800 putative NAD(P) binding site [chemical binding]; other site 399741013801 catalytic Zn binding site [ion binding]; other site 399741013802 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 399741013803 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 399741013804 TM-ABC transporter signature motif; other site 399741013805 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 399741013806 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 399741013807 Walker A/P-loop; other site 399741013808 ATP binding site [chemical binding]; other site 399741013809 Q-loop/lid; other site 399741013810 ABC transporter signature motif; other site 399741013811 Walker B; other site 399741013812 D-loop; other site 399741013813 H-loop/switch region; other site 399741013814 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 399741013815 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 399741013816 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 399741013817 ligand binding site [chemical binding]; other site 399741013818 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 399741013819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741013820 putative substrate translocation pore; other site 399741013821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741013822 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 399741013823 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 399741013824 TPR motif; other site 399741013825 binding surface 399741013826 TPR repeat; Region: TPR_11; pfam13414 399741013827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 399741013828 binding surface 399741013829 TPR motif; other site 399741013830 Tetratricopeptide repeat; Region: TPR_16; pfam13432 399741013831 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 399741013832 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 399741013833 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 399741013834 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 399741013835 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 399741013836 N-acetyl-D-glucosamine binding site [chemical binding]; other site 399741013837 catalytic residue [active] 399741013838 hypothetical protein; Provisional; Region: PRK01254 399741013839 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 399741013840 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 399741013841 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 399741013842 active site 399741013843 DNA binding site [nucleotide binding] 399741013844 Int/Topo IB signature motif; other site 399741013845 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 399741013846 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741013847 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 399741013848 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 399741013849 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 399741013850 Chitin binding domain; Region: Chitin_bind_3; pfam03067 399741013851 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; pfam09691 399741013852 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 399741013853 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 399741013854 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 399741013855 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 399741013856 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 399741013857 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 399741013858 GspL periplasmic domain; Region: GspL_C; cl14909 399741013859 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 399741013860 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 399741013861 type II secretion system protein J; Region: gspJ; TIGR01711 399741013862 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 399741013863 type II secretion system protein I; Region: gspI; TIGR01707 399741013864 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 399741013865 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 399741013866 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 399741013867 Type II transport protein GspH; Region: GspH; pfam12019 399741013868 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 399741013869 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 399741013870 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 399741013871 type II secretion system protein F; Region: GspF; TIGR02120 399741013872 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 399741013873 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 399741013874 type II secretion system protein E; Region: type_II_gspE; TIGR02533 399741013875 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 399741013876 Walker A motif; other site 399741013877 ATP binding site [chemical binding]; other site 399741013878 Walker B motif; other site 399741013879 type II secretion system protein D; Region: type_II_gspD; TIGR02517 399741013880 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 399741013881 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 399741013882 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 399741013883 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 399741013884 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 399741013885 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 399741013886 nucleoside transporter; Region: 2A0110; TIGR00889 399741013887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741013888 purine nucleoside phosphorylase; Provisional; Region: PRK08202 399741013889 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 399741013890 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741013891 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 399741013892 putative dimerization interface [polypeptide binding]; other site 399741013893 putative substrate binding pocket [chemical binding]; other site 399741013894 FtsI repressor; Provisional; Region: PRK10883 399741013895 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 399741013896 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 399741013897 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 399741013898 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 399741013899 putative acyl-acceptor binding pocket; other site 399741013900 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 399741013901 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 399741013902 CAP-like domain; other site 399741013903 active site 399741013904 primary dimer interface [polypeptide binding]; other site 399741013905 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 399741013906 Uncharacterized conserved protein [Function unknown]; Region: COG1359 399741013907 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741013908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741013909 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741013910 dimerization interface [polypeptide binding]; other site 399741013911 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 399741013912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741013913 ATP binding site [chemical binding]; other site 399741013914 Mg2+ binding site [ion binding]; other site 399741013915 G-X-G motif; other site 399741013916 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 399741013917 anchoring element; other site 399741013918 dimer interface [polypeptide binding]; other site 399741013919 ATP binding site [chemical binding]; other site 399741013920 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 399741013921 active site 399741013922 metal binding site [ion binding]; metal-binding site 399741013923 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 399741013924 esterase YqiA; Provisional; Region: PRK11071 399741013925 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 399741013926 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 399741013927 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 399741013928 active site 399741013929 metal binding site [ion binding]; metal-binding site 399741013930 hexamer interface [polypeptide binding]; other site 399741013931 putative dehydrogenase; Provisional; Region: PRK11039 399741013932 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 399741013933 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 399741013934 dimer interface [polypeptide binding]; other site 399741013935 ADP-ribose binding site [chemical binding]; other site 399741013936 active site 399741013937 nudix motif; other site 399741013938 metal binding site [ion binding]; metal-binding site 399741013939 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 399741013940 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 399741013941 GAF domain; Region: GAF; pfam01590 399741013942 PAS domain; Region: PAS; smart00091 399741013943 putative active site [active] 399741013944 heme pocket [chemical binding]; other site 399741013945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741013946 Walker A motif; other site 399741013947 ATP binding site [chemical binding]; other site 399741013948 Walker B motif; other site 399741013949 arginine finger; other site 399741013950 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 399741013951 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 399741013952 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 399741013953 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 399741013954 dimerization domain swap beta strand [polypeptide binding]; other site 399741013955 regulatory protein interface [polypeptide binding]; other site 399741013956 active site 399741013957 regulatory phosphorylation site [posttranslational modification]; other site 399741013958 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 399741013959 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 399741013960 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 399741013961 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 399741013962 Dak1 domain; Region: Dak1; pfam02733 399741013963 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 399741013964 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 399741013965 dimer interface [polypeptide binding]; other site 399741013966 active site 399741013967 metal binding site [ion binding]; metal-binding site 399741013968 hypothetical protein; Provisional; Region: PRK11653 399741013969 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 399741013970 glucose-6-phosphate isomerase; Provisional; Region: PRK04190 399741013971 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 399741013972 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 399741013973 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 399741013974 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 399741013975 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 399741013976 active site 399741013977 phosphorylation site [posttranslational modification] 399741013978 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 399741013979 active pocket/dimerization site; other site 399741013980 active site 399741013981 phosphorylation site [posttranslational modification] 399741013982 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 399741013983 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 399741013984 Transcriptional regulators [Transcription]; Region: PurR; COG1609 399741013985 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741013986 DNA binding site [nucleotide binding] 399741013987 domain linker motif; other site 399741013988 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 399741013989 putative ligand binding site [chemical binding]; other site 399741013990 putative dimerization interface [polypeptide binding]; other site 399741013991 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 399741013992 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 399741013993 putative active site [active] 399741013994 metal binding site [ion binding]; metal-binding site 399741013995 zinc transporter ZupT; Provisional; Region: PRK04201 399741013996 ZIP Zinc transporter; Region: Zip; pfam02535 399741013997 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 399741013998 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 399741013999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 399741014000 putative transporter; Provisional; Region: PRK11021 399741014001 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 399741014002 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 399741014003 putative ribose interaction site [chemical binding]; other site 399741014004 putative ADP binding site [chemical binding]; other site 399741014005 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 399741014006 active site 399741014007 nucleotide binding site [chemical binding]; other site 399741014008 HIGH motif; other site 399741014009 KMSKS motif; other site 399741014010 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 399741014011 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 399741014012 metal binding triad; other site 399741014013 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 399741014014 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 399741014015 metal binding triad; other site 399741014016 Uncharacterized conserved protein [Function unknown]; Region: COG3025 399741014017 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 399741014018 putative active site [active] 399741014019 putative metal binding residues [ion binding]; other site 399741014020 signature motif; other site 399741014021 putative triphosphate binding site [ion binding]; other site 399741014022 CHAD domain; Region: CHAD; pfam05235 399741014023 SH3 domain-containing protein; Provisional; Region: PRK10884 399741014024 Bacterial SH3 domain homologues; Region: SH3b; smart00287 399741014025 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 399741014026 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 399741014027 active site 399741014028 NTP binding site [chemical binding]; other site 399741014029 metal binding triad [ion binding]; metal-binding site 399741014030 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 399741014031 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 399741014032 Zn2+ binding site [ion binding]; other site 399741014033 Mg2+ binding site [ion binding]; other site 399741014034 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 399741014035 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 399741014036 homooctamer interface [polypeptide binding]; other site 399741014037 active site 399741014038 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 399741014039 UGMP family protein; Validated; Region: PRK09604 399741014040 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 399741014041 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 399741014042 DNA primase; Validated; Region: dnaG; PRK05667 399741014043 CHC2 zinc finger; Region: zf-CHC2; pfam01807 399741014044 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 399741014045 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 399741014046 active site 399741014047 metal binding site [ion binding]; metal-binding site 399741014048 interdomain interaction site; other site 399741014049 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 399741014050 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 399741014051 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 399741014052 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 399741014053 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 399741014054 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 399741014055 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 399741014056 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 399741014057 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 399741014058 DNA binding residues [nucleotide binding] 399741014059 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 399741014060 active site 399741014061 SUMO-1 interface [polypeptide binding]; other site 399741014062 HPP family; Region: HPP; pfam04982 399741014063 glutathione S-transferase; Provisional; Region: PRK15113 399741014064 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 399741014065 C-terminal domain interface [polypeptide binding]; other site 399741014066 GSH binding site (G-site) [chemical binding]; other site 399741014067 dimer interface [polypeptide binding]; other site 399741014068 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 399741014069 N-terminal domain interface [polypeptide binding]; other site 399741014070 putative dimer interface [polypeptide binding]; other site 399741014071 putative substrate binding pocket (H-site) [chemical binding]; other site 399741014072 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 399741014073 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 399741014074 succinic semialdehyde dehydrogenase; Region: PLN02278 399741014075 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 399741014076 tetramerization interface [polypeptide binding]; other site 399741014077 NAD(P) binding site [chemical binding]; other site 399741014078 catalytic residues [active] 399741014079 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 399741014080 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 399741014081 inhibitor-cofactor binding pocket; inhibition site 399741014082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741014083 catalytic residue [active] 399741014084 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 399741014085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741014086 DNA-binding site [nucleotide binding]; DNA binding site 399741014087 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741014088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741014089 homodimer interface [polypeptide binding]; other site 399741014090 catalytic residue [active] 399741014091 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 399741014092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741014093 Walker A/P-loop; other site 399741014094 ATP binding site [chemical binding]; other site 399741014095 Q-loop/lid; other site 399741014096 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 399741014097 ABC transporter signature motif; other site 399741014098 Walker B; other site 399741014099 D-loop; other site 399741014100 ABC transporter; Region: ABC_tran_2; pfam12848 399741014101 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 399741014102 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 399741014103 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 399741014104 active site 399741014105 FMN binding site [chemical binding]; other site 399741014106 2,4-decadienoyl-CoA binding site; other site 399741014107 catalytic residue [active] 399741014108 4Fe-4S cluster binding site [ion binding]; other site 399741014109 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 399741014110 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 399741014111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741014112 non-specific DNA binding site [nucleotide binding]; other site 399741014113 salt bridge; other site 399741014114 sequence-specific DNA binding site [nucleotide binding]; other site 399741014115 HipA N-terminal domain; Region: Couple_hipA; pfam13657 399741014116 HipA-like N-terminal domain; Region: HipA_N; pfam07805 399741014117 HipA-like C-terminal domain; Region: HipA_C; pfam07804 399741014118 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 399741014119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741014120 S-adenosylmethionine binding site [chemical binding]; other site 399741014121 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 399741014122 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 399741014123 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 399741014124 sequence-specific DNA binding site [nucleotide binding]; other site 399741014125 salt bridge; other site 399741014126 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 399741014127 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 399741014128 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 399741014129 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 399741014130 catalytic triad [active] 399741014131 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 399741014132 serine/threonine transporter SstT; Provisional; Region: PRK13628 399741014133 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 399741014134 galactarate dehydratase; Region: galactar-dH20; TIGR03248 399741014135 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 399741014136 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 399741014137 Glucuronate isomerase; Region: UxaC; pfam02614 399741014138 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 399741014139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741014140 D-galactonate transporter; Region: 2A0114; TIGR00893 399741014141 putative substrate translocation pore; other site 399741014142 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 399741014143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741014144 DNA-binding site [nucleotide binding]; DNA binding site 399741014145 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 399741014146 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 399741014147 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 399741014148 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 399741014149 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 399741014150 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 399741014151 Predicted membrane protein [Function unknown]; Region: COG5393 399741014152 YqjK-like protein; Region: YqjK; pfam13997 399741014153 Predicted membrane protein [Function unknown]; Region: COG2259 399741014154 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 399741014155 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 399741014156 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 399741014157 putative dimer interface [polypeptide binding]; other site 399741014158 N-terminal domain interface [polypeptide binding]; other site 399741014159 putative substrate binding pocket (H-site) [chemical binding]; other site 399741014160 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741014161 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 399741014162 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 399741014163 dimerization interface [polypeptide binding]; other site 399741014164 Pirin-related protein [General function prediction only]; Region: COG1741 399741014165 Pirin; Region: Pirin; pfam02678 399741014166 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 399741014167 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 399741014168 putative SAM binding site [chemical binding]; other site 399741014169 putative homodimer interface [polypeptide binding]; other site 399741014170 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 399741014171 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 399741014172 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 399741014173 putative ligand binding site [chemical binding]; other site 399741014174 hypothetical protein; Reviewed; Region: PRK12497 399741014175 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 399741014176 dimer interface [polypeptide binding]; other site 399741014177 active site 399741014178 outer membrane lipoprotein; Provisional; Region: PRK11023 399741014179 bacterial OsmY and nodulation domain; Region: BON; smart00749 399741014180 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 399741014181 Transglycosylase; Region: Transgly; cl17702 399741014182 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 399741014183 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 399741014184 conserved cys residue [active] 399741014185 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 399741014186 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 399741014187 putative active site [active] 399741014188 heme pocket [chemical binding]; other site 399741014189 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741014190 dimer interface [polypeptide binding]; other site 399741014191 phosphorylation site [posttranslational modification] 399741014192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741014193 ATP binding site [chemical binding]; other site 399741014194 Mg2+ binding site [ion binding]; other site 399741014195 G-X-G motif; other site 399741014196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741014197 active site 399741014198 phosphorylation site [posttranslational modification] 399741014199 intermolecular recognition site; other site 399741014200 dimerization interface [polypeptide binding]; other site 399741014201 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 399741014202 putative binding surface; other site 399741014203 active site 399741014204 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 399741014205 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 399741014206 FeS/SAM binding site; other site 399741014207 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 399741014208 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 399741014209 active site 399741014210 dimer interface [polypeptide binding]; other site 399741014211 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 399741014212 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 399741014213 active site 399741014214 FMN binding site [chemical binding]; other site 399741014215 substrate binding site [chemical binding]; other site 399741014216 3Fe-4S cluster binding site [ion binding]; other site 399741014217 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 399741014218 domain interface; other site 399741014219 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 399741014220 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 399741014221 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 399741014222 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 399741014223 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 399741014224 stringent starvation protein A; Provisional; Region: sspA; PRK09481 399741014225 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 399741014226 C-terminal domain interface [polypeptide binding]; other site 399741014227 putative GSH binding site (G-site) [chemical binding]; other site 399741014228 dimer interface [polypeptide binding]; other site 399741014229 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 399741014230 dimer interface [polypeptide binding]; other site 399741014231 N-terminal domain interface [polypeptide binding]; other site 399741014232 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 399741014233 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 399741014234 23S rRNA interface [nucleotide binding]; other site 399741014235 L3 interface [polypeptide binding]; other site 399741014236 Predicted ATPase [General function prediction only]; Region: COG1485 399741014237 hypothetical protein; Provisional; Region: PRK11677 399741014238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 399741014239 serine endoprotease; Provisional; Region: PRK10139 399741014240 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 399741014241 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 399741014242 protein binding site [polypeptide binding]; other site 399741014243 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 399741014244 serine endoprotease; Provisional; Region: PRK10898 399741014245 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 399741014246 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 399741014247 protein binding site [polypeptide binding]; other site 399741014248 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 399741014249 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 399741014250 hinge; other site 399741014251 active site 399741014252 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 399741014253 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 399741014254 anti sigma factor interaction site; other site 399741014255 regulatory phosphorylation site [posttranslational modification]; other site 399741014256 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 399741014257 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 399741014258 mce related protein; Region: MCE; pfam02470 399741014259 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 399741014260 conserved hypothetical integral membrane protein; Region: TIGR00056 399741014261 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 399741014262 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 399741014263 Walker A/P-loop; other site 399741014264 ATP binding site [chemical binding]; other site 399741014265 Q-loop/lid; other site 399741014266 ABC transporter signature motif; other site 399741014267 Walker B; other site 399741014268 D-loop; other site 399741014269 H-loop/switch region; other site 399741014270 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 399741014271 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 399741014272 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 399741014273 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 399741014274 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 399741014275 putative active site [active] 399741014276 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 399741014277 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 399741014278 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 399741014279 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 399741014280 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 399741014281 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 399741014282 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 399741014283 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 399741014284 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 399741014285 Walker A/P-loop; other site 399741014286 ATP binding site [chemical binding]; other site 399741014287 Q-loop/lid; other site 399741014288 ABC transporter signature motif; other site 399741014289 Walker B; other site 399741014290 D-loop; other site 399741014291 H-loop/switch region; other site 399741014292 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 399741014293 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 399741014294 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 399741014295 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 399741014296 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 399741014297 30S subunit binding site; other site 399741014298 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 399741014299 active site 399741014300 phosphorylation site [posttranslational modification] 399741014301 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 399741014302 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 399741014303 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 399741014304 dimerization domain swap beta strand [polypeptide binding]; other site 399741014305 regulatory protein interface [polypeptide binding]; other site 399741014306 active site 399741014307 regulatory phosphorylation site [posttranslational modification]; other site 399741014308 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 399741014309 HTH domain; Region: HTH_11; pfam08279 399741014310 Mga helix-turn-helix domain; Region: Mga; pfam05043 399741014311 PRD domain; Region: PRD; pfam00874 399741014312 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 399741014313 active site 399741014314 P-loop; other site 399741014315 phosphorylation site [posttranslational modification] 399741014316 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 399741014317 active site 399741014318 phosphorylation site [posttranslational modification] 399741014319 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 399741014320 Protein of unknown function (DUF1341); Region: DUF1341; pfam07071 399741014321 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 399741014322 dihydroorotase; Provisional; Region: PRK09237 399741014323 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 399741014324 active site 399741014325 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 399741014326 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 399741014327 Domain of unknown function (DUF4312); Region: DUF4312; pfam14189 399741014328 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 399741014329 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 399741014330 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 399741014331 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 399741014332 Cytochrome b562; Region: Cytochrom_B562; cl01546 399741014333 peptidase PmbA; Provisional; Region: PRK11040 399741014334 Helix-turn-helix domain; Region: HTH_37; pfam13744 399741014335 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 399741014336 hypothetical protein; Provisional; Region: PRK05255 399741014337 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 399741014338 RNAase interaction site [polypeptide binding]; other site 399741014339 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 399741014340 active site 399741014341 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 399741014342 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 399741014343 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 399741014344 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 399741014345 HlyD family secretion protein; Region: HlyD_3; pfam13437 399741014346 efflux system membrane protein; Provisional; Region: PRK11594 399741014347 transcriptional regulator; Provisional; Region: PRK10632 399741014348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741014349 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 399741014350 putative effector binding pocket; other site 399741014351 dimerization interface [polypeptide binding]; other site 399741014352 Double zinc ribbon; Region: DZR; pfam12773 399741014353 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 399741014354 active site 399741014355 tetramer interface [polypeptide binding]; other site 399741014356 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 399741014357 haemagglutination activity domain; Region: Haemagg_act; pfam05860 399741014358 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 399741014359 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 399741014360 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 399741014361 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 399741014362 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 399741014363 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 399741014364 protease TldD; Provisional; Region: tldD; PRK10735 399741014365 nitrilase; Region: PLN02798 399741014366 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 399741014367 putative active site [active] 399741014368 catalytic triad [active] 399741014369 dimer interface [polypeptide binding]; other site 399741014370 hypothetical protein; Provisional; Region: PRK10899 399741014371 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 399741014372 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 399741014373 ribonuclease G; Provisional; Region: PRK11712 399741014374 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 399741014375 homodimer interface [polypeptide binding]; other site 399741014376 oligonucleotide binding site [chemical binding]; other site 399741014377 Maf-like protein; Region: Maf; pfam02545 399741014378 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 399741014379 active site 399741014380 dimer interface [polypeptide binding]; other site 399741014381 rod shape-determining protein MreD; Provisional; Region: PRK11060 399741014382 rod shape-determining protein MreC; Region: mreC; TIGR00219 399741014383 rod shape-determining protein MreC; Region: MreC; pfam04085 399741014384 rod shape-determining protein MreB; Provisional; Region: PRK13927 399741014385 MreB and similar proteins; Region: MreB_like; cd10225 399741014386 nucleotide binding site [chemical binding]; other site 399741014387 Mg binding site [ion binding]; other site 399741014388 putative protofilament interaction site [polypeptide binding]; other site 399741014389 RodZ interaction site [polypeptide binding]; other site 399741014390 regulatory protein CsrD; Provisional; Region: PRK11059 399741014391 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 399741014392 metal binding site [ion binding]; metal-binding site 399741014393 active site 399741014394 I-site; other site 399741014395 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 399741014396 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 399741014397 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 399741014398 NADP binding site [chemical binding]; other site 399741014399 dimer interface [polypeptide binding]; other site 399741014400 TMAO/DMSO reductase; Reviewed; Region: PRK05363 399741014401 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 399741014402 Moco binding site; other site 399741014403 metal coordination site [ion binding]; other site 399741014404 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 399741014405 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 399741014406 Dehydroquinase class II; Region: DHquinase_II; pfam01220 399741014407 active site 399741014408 trimer interface [polypeptide binding]; other site 399741014409 dimer interface [polypeptide binding]; other site 399741014410 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 399741014411 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 399741014412 carboxyltransferase (CT) interaction site; other site 399741014413 biotinylation site [posttranslational modification]; other site 399741014414 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 399741014415 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 399741014416 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 399741014417 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 399741014418 hypothetical protein; Provisional; Region: PRK10633 399741014419 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 399741014420 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 399741014421 Na binding site [ion binding]; other site 399741014422 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 399741014423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 399741014424 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 399741014425 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 399741014426 active site 399741014427 zinc binding site [ion binding]; other site 399741014428 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 399741014429 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 399741014430 FMN binding site [chemical binding]; other site 399741014431 active site 399741014432 catalytic residues [active] 399741014433 substrate binding site [chemical binding]; other site 399741014434 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 399741014435 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 399741014436 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 399741014437 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 399741014438 putative acyl-acceptor binding pocket; other site 399741014439 hypothetical protein; Validated; Region: PRK06186 399741014440 conserved cys residue [active] 399741014441 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 399741014442 LrgA family; Region: LrgA; cl00608 399741014443 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741014444 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741014445 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 399741014446 putative dimerization interface [polypeptide binding]; other site 399741014447 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 399741014448 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 399741014449 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 399741014450 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 399741014451 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 399741014452 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 399741014453 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 399741014454 putative C-terminal domain interface [polypeptide binding]; other site 399741014455 putative GSH binding site (G-site) [chemical binding]; other site 399741014456 putative dimer interface [polypeptide binding]; other site 399741014457 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 399741014458 putative N-terminal domain interface [polypeptide binding]; other site 399741014459 putative dimer interface [polypeptide binding]; other site 399741014460 putative substrate binding pocket (H-site) [chemical binding]; other site 399741014461 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 399741014462 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 399741014463 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741014464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741014465 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 399741014466 putative effector binding pocket; other site 399741014467 dimerization interface [polypeptide binding]; other site 399741014468 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 399741014469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 399741014470 NAD(P) binding site [chemical binding]; other site 399741014471 active site 399741014472 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623 399741014473 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741014474 substrate binding pocket [chemical binding]; other site 399741014475 membrane-bound complex binding site; other site 399741014476 hinge residues; other site 399741014477 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 399741014478 N-acetyl-D-glucosamine binding site [chemical binding]; other site 399741014479 catalytic residue [active] 399741014480 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 399741014481 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 399741014482 dimer interface [polypeptide binding]; other site 399741014483 ssDNA binding site [nucleotide binding]; other site 399741014484 tetramer (dimer of dimers) interface [polypeptide binding]; other site 399741014485 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 399741014486 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 399741014487 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 399741014488 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 399741014489 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 399741014490 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 399741014491 putative NAD(P) binding site [chemical binding]; other site 399741014492 putative substrate binding site [chemical binding]; other site 399741014493 catalytic Zn binding site [ion binding]; other site 399741014494 structural Zn binding site [ion binding]; other site 399741014495 dimer interface [polypeptide binding]; other site 399741014496 maltose O-acetyltransferase; Provisional; Region: PRK10092 399741014497 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 399741014498 active site 399741014499 substrate binding site [chemical binding]; other site 399741014500 trimer interface [polypeptide binding]; other site 399741014501 CoA binding site [chemical binding]; other site 399741014502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 399741014503 Uncharacterized conserved protein [Function unknown]; Region: COG0432 399741014504 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 399741014505 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 399741014506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741014507 homodimer interface [polypeptide binding]; other site 399741014508 catalytic residue [active] 399741014509 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 399741014510 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 399741014511 putative DNA binding site [nucleotide binding]; other site 399741014512 putative Zn2+ binding site [ion binding]; other site 399741014513 AsnC family; Region: AsnC_trans_reg; pfam01037 399741014514 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741014515 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 399741014516 substrate binding pocket [chemical binding]; other site 399741014517 membrane-bound complex binding site; other site 399741014518 hinge residues; other site 399741014519 alanine racemase; Reviewed; Region: alr; PRK00053 399741014520 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 399741014521 active site 399741014522 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 399741014523 substrate binding site [chemical binding]; other site 399741014524 catalytic residues [active] 399741014525 dimer interface [polypeptide binding]; other site 399741014526 replicative DNA helicase; Provisional; Region: PRK08006 399741014527 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 399741014528 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 399741014529 Walker A motif; other site 399741014530 ATP binding site [chemical binding]; other site 399741014531 Walker B motif; other site 399741014532 DNA binding loops [nucleotide binding] 399741014533 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 399741014534 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 399741014535 NADP binding site [chemical binding]; other site 399741014536 dimer interface [polypeptide binding]; other site 399741014537 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 399741014538 phage shock protein G; Reviewed; Region: pspG; PRK09459 399741014539 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 399741014540 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 399741014541 FMN binding site [chemical binding]; other site 399741014542 active site 399741014543 catalytic residues [active] 399741014544 substrate binding site [chemical binding]; other site 399741014545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 399741014546 binding surface 399741014547 TPR motif; other site 399741014548 Tetratricopeptide repeat; Region: TPR_16; pfam13432 399741014549 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 399741014550 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 399741014551 DNA binding residues [nucleotide binding] 399741014552 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 399741014553 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 399741014554 metal binding site 2 [ion binding]; metal-binding site 399741014555 putative DNA binding helix; other site 399741014556 metal binding site 1 [ion binding]; metal-binding site 399741014557 dimer interface [polypeptide binding]; other site 399741014558 structural Zn2+ binding site [ion binding]; other site 399741014559 hypothetical protein; Provisional; Region: PRK10428 399741014560 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 399741014561 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 399741014562 LexA repressor; Validated; Region: PRK00215 399741014563 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 399741014564 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 399741014565 Catalytic site [active] 399741014566 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 399741014567 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 399741014568 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 399741014569 putative acyl-acceptor binding pocket; other site 399741014570 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 399741014571 UbiA prenyltransferase family; Region: UbiA; pfam01040 399741014572 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 399741014573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741014574 metabolite-proton symporter; Region: 2A0106; TIGR00883 399741014575 putative substrate translocation pore; other site 399741014576 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741014577 DNA binding site [nucleotide binding] 399741014578 Transcriptional regulators [Transcription]; Region: PurR; COG1609 399741014579 domain linker motif; other site 399741014580 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 399741014581 dimerization interface [polypeptide binding]; other site 399741014582 ligand binding site [chemical binding]; other site 399741014583 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 399741014584 active site 399741014585 maltose regulon periplasmic protein; Provisional; Region: PRK10564 399741014586 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 399741014587 trimer interface; other site 399741014588 sugar binding site [chemical binding]; other site 399741014589 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 399741014590 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 399741014591 Walker A/P-loop; other site 399741014592 ATP binding site [chemical binding]; other site 399741014593 Q-loop/lid; other site 399741014594 ABC transporter signature motif; other site 399741014595 Walker B; other site 399741014596 D-loop; other site 399741014597 H-loop/switch region; other site 399741014598 TOBE domain; Region: TOBE_2; pfam08402 399741014599 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 399741014600 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 399741014601 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 399741014602 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 399741014603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741014604 dimer interface [polypeptide binding]; other site 399741014605 conserved gate region; other site 399741014606 putative PBP binding loops; other site 399741014607 ABC-ATPase subunit interface; other site 399741014608 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 399741014609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741014610 dimer interface [polypeptide binding]; other site 399741014611 conserved gate region; other site 399741014612 putative PBP binding loops; other site 399741014613 ABC-ATPase subunit interface; other site 399741014614 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 399741014615 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 399741014616 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 399741014617 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 399741014618 active site 399741014619 dimer interface [polypeptide binding]; other site 399741014620 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 399741014621 dimer interface [polypeptide binding]; other site 399741014622 active site 399741014623 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 399741014624 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 399741014625 TrkA-N domain; Region: TrkA_N; pfam02254 399741014626 aspartate kinase III; Validated; Region: PRK09084 399741014627 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 399741014628 nucleotide binding site [chemical binding]; other site 399741014629 substrate binding site [chemical binding]; other site 399741014630 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 399741014631 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 399741014632 dimer interface [polypeptide binding]; other site 399741014633 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 399741014634 Sodium Bile acid symporter family; Region: SBF; pfam01758 399741014635 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 399741014636 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 399741014637 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 399741014638 haemagglutination activity domain; Region: Haemagg_act; pfam05860 399741014639 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 399741014640 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 399741014641 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 399741014642 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 399741014643 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 399741014644 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 399741014645 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 399741014646 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 399741014647 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 399741014648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741014649 Walker A/P-loop; other site 399741014650 ATP binding site [chemical binding]; other site 399741014651 Q-loop/lid; other site 399741014652 ABC transporter signature motif; other site 399741014653 Walker B; other site 399741014654 D-loop; other site 399741014655 H-loop/switch region; other site 399741014656 TOBE domain; Region: TOBE_2; pfam08402 399741014657 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 399741014658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741014659 dimer interface [polypeptide binding]; other site 399741014660 conserved gate region; other site 399741014661 putative PBP binding loops; other site 399741014662 ABC-ATPase subunit interface; other site 399741014663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 399741014664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741014665 putative PBP binding loops; other site 399741014666 ABC-ATPase subunit interface; other site 399741014667 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 399741014668 Sulfatase; Region: Sulfatase; cl17466 399741014669 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 399741014670 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 399741014671 transcriptional regulator protein; Region: phnR; TIGR03337 399741014672 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741014673 DNA-binding site [nucleotide binding]; DNA binding site 399741014674 UTRA domain; Region: UTRA; pfam07702 399741014675 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 399741014676 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 399741014677 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 399741014678 substrate binding pocket [chemical binding]; other site 399741014679 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 399741014680 B12 binding site [chemical binding]; other site 399741014681 cobalt ligand [ion binding]; other site 399741014682 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 399741014683 transcriptional repressor IclR; Provisional; Region: PRK11569 399741014684 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 399741014685 Bacterial transcriptional regulator; Region: IclR; pfam01614 399741014686 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 399741014687 active site 399741014688 substrate binding pocket [chemical binding]; other site 399741014689 homodimer interaction site [polypeptide binding]; other site 399741014690 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 399741014691 Protein of unknown function; Region: YhfT; pfam10797 399741014692 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 399741014693 active site 399741014694 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 399741014695 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 399741014696 ATP-binding site [chemical binding]; other site 399741014697 Gluconate-6-phosphate binding site [chemical binding]; other site 399741014698 low affinity gluconate transporter; Provisional; Region: PRK10472 399741014699 gluconate transporter; Region: gntP; TIGR00791 399741014700 phosphogluconate dehydratase; Validated; Region: PRK09054 399741014701 6-phosphogluconate dehydratase; Region: edd; TIGR01196 399741014702 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 399741014703 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 399741014704 active site 399741014705 intersubunit interface [polypeptide binding]; other site 399741014706 catalytic residue [active] 399741014707 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 399741014708 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 399741014709 isocitrate lyase; Provisional; Region: PRK15063 399741014710 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 399741014711 tetramer interface [polypeptide binding]; other site 399741014712 active site 399741014713 Mg2+/Mn2+ binding site [ion binding]; other site 399741014714 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 399741014715 malate synthase A; Region: malate_syn_A; TIGR01344 399741014716 active site 399741014717 homoserine O-succinyltransferase; Provisional; Region: PRK05368 399741014718 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 399741014719 proposed active site lysine [active] 399741014720 conserved cys residue [active] 399741014721 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 399741014722 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 399741014723 trimer interface [polypeptide binding]; other site 399741014724 putative metal binding site [ion binding]; other site 399741014725 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 399741014726 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 399741014727 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 399741014728 shikimate binding site; other site 399741014729 NAD(P) binding site [chemical binding]; other site 399741014730 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 399741014731 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 399741014732 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 399741014733 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 399741014734 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 399741014735 hypothetical protein; Validated; Region: PRK03430 399741014736 hypothetical protein; Provisional; Region: PRK10736 399741014737 DNA protecting protein DprA; Region: dprA; TIGR00732 399741014738 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 399741014739 active site 399741014740 catalytic residues [active] 399741014741 metal binding site [ion binding]; metal-binding site 399741014742 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 399741014743 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 399741014744 putative active site [active] 399741014745 substrate binding site [chemical binding]; other site 399741014746 putative cosubstrate binding site; other site 399741014747 catalytic site [active] 399741014748 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 399741014749 substrate binding site [chemical binding]; other site 399741014750 16S rRNA methyltransferase B; Provisional; Region: PRK10901 399741014751 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 399741014752 putative RNA binding site [nucleotide binding]; other site 399741014753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741014754 S-adenosylmethionine binding site [chemical binding]; other site 399741014755 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 399741014756 TrkA-N domain; Region: TrkA_N; pfam02254 399741014757 TrkA-C domain; Region: TrkA_C; pfam02080 399741014758 TrkA-N domain; Region: TrkA_N; pfam02254 399741014759 TrkA-C domain; Region: TrkA_C; pfam02080 399741014760 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 399741014761 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 399741014762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 399741014763 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 399741014764 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 399741014765 DNA binding residues [nucleotide binding] 399741014766 dimer interface [polypeptide binding]; other site 399741014767 metal binding site [ion binding]; metal-binding site 399741014768 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 399741014769 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 399741014770 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 399741014771 alphaNTD homodimer interface [polypeptide binding]; other site 399741014772 alphaNTD - beta interaction site [polypeptide binding]; other site 399741014773 alphaNTD - beta' interaction site [polypeptide binding]; other site 399741014774 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 399741014775 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 399741014776 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 399741014777 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 399741014778 RNA binding surface [nucleotide binding]; other site 399741014779 30S ribosomal protein S11; Validated; Region: PRK05309 399741014780 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 399741014781 30S ribosomal protein S13; Region: bact_S13; TIGR03631 399741014782 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 399741014783 SecY translocase; Region: SecY; pfam00344 399741014784 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 399741014785 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 399741014786 23S rRNA binding site [nucleotide binding]; other site 399741014787 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 399741014788 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 399741014789 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 399741014790 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 399741014791 5S rRNA interface [nucleotide binding]; other site 399741014792 23S rRNA interface [nucleotide binding]; other site 399741014793 L5 interface [polypeptide binding]; other site 399741014794 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 399741014795 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 399741014796 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 399741014797 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 399741014798 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 399741014799 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 399741014800 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 399741014801 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 399741014802 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 399741014803 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 399741014804 RNA binding site [nucleotide binding]; other site 399741014805 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 399741014806 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 399741014807 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 399741014808 23S rRNA interface [nucleotide binding]; other site 399741014809 putative translocon interaction site; other site 399741014810 signal recognition particle (SRP54) interaction site; other site 399741014811 L23 interface [polypeptide binding]; other site 399741014812 trigger factor interaction site; other site 399741014813 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 399741014814 23S rRNA interface [nucleotide binding]; other site 399741014815 5S rRNA interface [nucleotide binding]; other site 399741014816 putative antibiotic binding site [chemical binding]; other site 399741014817 L25 interface [polypeptide binding]; other site 399741014818 L27 interface [polypeptide binding]; other site 399741014819 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 399741014820 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 399741014821 G-X-X-G motif; other site 399741014822 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 399741014823 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 399741014824 protein-rRNA interface [nucleotide binding]; other site 399741014825 putative translocon binding site; other site 399741014826 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 399741014827 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 399741014828 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 399741014829 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 399741014830 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 399741014831 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 399741014832 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 399741014833 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 399741014834 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 399741014835 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 399741014836 heme binding site [chemical binding]; other site 399741014837 ferroxidase pore; other site 399741014838 ferroxidase diiron center [ion binding]; other site 399741014839 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 399741014840 elongation factor Tu; Reviewed; Region: PRK00049 399741014841 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 399741014842 G1 box; other site 399741014843 GEF interaction site [polypeptide binding]; other site 399741014844 GTP/Mg2+ binding site [chemical binding]; other site 399741014845 Switch I region; other site 399741014846 G2 box; other site 399741014847 G3 box; other site 399741014848 Switch II region; other site 399741014849 G4 box; other site 399741014850 G5 box; other site 399741014851 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 399741014852 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 399741014853 Antibiotic Binding Site [chemical binding]; other site 399741014854 elongation factor G; Reviewed; Region: PRK00007 399741014855 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 399741014856 G1 box; other site 399741014857 putative GEF interaction site [polypeptide binding]; other site 399741014858 GTP/Mg2+ binding site [chemical binding]; other site 399741014859 Switch I region; other site 399741014860 G2 box; other site 399741014861 G3 box; other site 399741014862 Switch II region; other site 399741014863 G4 box; other site 399741014864 G5 box; other site 399741014865 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 399741014866 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 399741014867 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 399741014868 30S ribosomal protein S7; Validated; Region: PRK05302 399741014869 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 399741014870 S17 interaction site [polypeptide binding]; other site 399741014871 S8 interaction site; other site 399741014872 16S rRNA interaction site [nucleotide binding]; other site 399741014873 streptomycin interaction site [chemical binding]; other site 399741014874 23S rRNA interaction site [nucleotide binding]; other site 399741014875 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 399741014876 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 399741014877 sulfur relay protein TusC; Validated; Region: PRK00211 399741014878 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 399741014879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 399741014880 YheO-like PAS domain; Region: PAS_6; pfam08348 399741014881 HTH domain; Region: HTH_22; pfam13309 399741014882 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 399741014883 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 399741014884 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 399741014885 phi X174 lysis protein; Provisional; Region: PRK02793 399741014886 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 399741014887 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 399741014888 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 399741014889 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 399741014890 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 399741014891 TrkA-N domain; Region: TrkA_N; pfam02254 399741014892 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 399741014893 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 399741014894 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 399741014895 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 399741014896 ABC transporter; Region: ABC_tran_2; pfam12848 399741014897 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 399741014898 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 399741014899 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 399741014900 substrate binding pocket [chemical binding]; other site 399741014901 active site 399741014902 iron coordination sites [ion binding]; other site 399741014903 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 399741014904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 399741014905 dimer interface [polypeptide binding]; other site 399741014906 conserved gate region; other site 399741014907 putative PBP binding loops; other site 399741014908 ABC-ATPase subunit interface; other site 399741014909 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 399741014910 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 399741014911 Walker A/P-loop; other site 399741014912 ATP binding site [chemical binding]; other site 399741014913 Q-loop/lid; other site 399741014914 ABC transporter signature motif; other site 399741014915 Walker B; other site 399741014916 D-loop; other site 399741014917 H-loop/switch region; other site 399741014918 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 399741014919 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741014920 substrate binding pocket [chemical binding]; other site 399741014921 membrane-bound complex binding site; other site 399741014922 hinge residues; other site 399741014923 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 399741014924 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 399741014925 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 399741014926 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 399741014927 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 399741014928 Metal-binding active site; metal-binding site 399741014929 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 399741014930 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 399741014931 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 399741014932 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 399741014933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741014934 putative substrate translocation pore; other site 399741014935 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 399741014936 Coenzyme A binding pocket [chemical binding]; other site 399741014937 Transcriptional regulators [Transcription]; Region: PurR; COG1609 399741014938 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741014939 DNA binding site [nucleotide binding] 399741014940 domain linker motif; other site 399741014941 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 399741014942 ligand binding site [chemical binding]; other site 399741014943 dimerization interface [polypeptide binding]; other site 399741014944 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 399741014945 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 399741014946 putative hydrolase; Provisional; Region: PRK10985 399741014947 hypothetical protein; Provisional; Region: PRK04966 399741014948 phosphoribulokinase; Provisional; Region: PRK15453 399741014949 hypothetical protein; Provisional; Region: PRK10738 399741014950 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 399741014951 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 399741014952 ligand binding site [chemical binding]; other site 399741014953 flexible hinge region; other site 399741014954 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 399741014955 putative switch regulator; other site 399741014956 non-specific DNA interactions [nucleotide binding]; other site 399741014957 DNA binding site [nucleotide binding] 399741014958 sequence specific DNA binding site [nucleotide binding]; other site 399741014959 putative cAMP binding site [chemical binding]; other site 399741014960 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 399741014961 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 399741014962 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 399741014963 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 399741014964 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 399741014965 inhibitor-cofactor binding pocket; inhibition site 399741014966 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741014967 catalytic residue [active] 399741014968 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 399741014969 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 399741014970 glutamine binding [chemical binding]; other site 399741014971 catalytic triad [active] 399741014972 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 399741014973 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 399741014974 Walker A motif; other site 399741014975 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 399741014976 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 399741014977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741014978 active site 399741014979 phosphorylation site [posttranslational modification] 399741014980 intermolecular recognition site; other site 399741014981 dimerization interface [polypeptide binding]; other site 399741014982 LytTr DNA-binding domain; Region: LytTR; pfam04397 399741014983 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 399741014984 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 399741014985 GAF domain; Region: GAF; pfam01590 399741014986 Histidine kinase; Region: His_kinase; pfam06580 399741014987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741014988 ATP binding site [chemical binding]; other site 399741014989 Mg2+ binding site [ion binding]; other site 399741014990 G-X-G motif; other site 399741014991 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 399741014992 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 399741014993 active site 399741014994 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 399741014995 active site 399741014996 methionine cluster; other site 399741014997 phosphorylation site [posttranslational modification] 399741014998 metal binding site [ion binding]; metal-binding site 399741014999 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 399741015000 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 399741015001 NAD binding site [chemical binding]; other site 399741015002 sugar binding site [chemical binding]; other site 399741015003 divalent metal binding site [ion binding]; other site 399741015004 tetramer (dimer of dimers) interface [polypeptide binding]; other site 399741015005 dimer interface [polypeptide binding]; other site 399741015006 Transcriptional regulators [Transcription]; Region: PurR; COG1609 399741015007 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741015008 DNA binding site [nucleotide binding] 399741015009 domain linker motif; other site 399741015010 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 399741015011 dimerization interface (closed form) [polypeptide binding]; other site 399741015012 ligand binding site [chemical binding]; other site 399741015013 putative transporter; Provisional; Region: PRK03699 399741015014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741015015 putative substrate translocation pore; other site 399741015016 cytosine deaminase; Provisional; Region: PRK09230 399741015017 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 399741015018 active site 399741015019 nitrite reductase subunit NirD; Provisional; Region: PRK14989 399741015020 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 399741015021 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 399741015022 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 399741015023 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 399741015024 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 399741015025 nitrite transporter NirC; Provisional; Region: PRK11562 399741015026 siroheme synthase; Provisional; Region: cysG; PRK10637 399741015027 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 399741015028 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 399741015029 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 399741015030 active site 399741015031 SAM binding site [chemical binding]; other site 399741015032 homodimer interface [polypeptide binding]; other site 399741015033 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 399741015034 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 399741015035 active site 399741015036 HIGH motif; other site 399741015037 dimer interface [polypeptide binding]; other site 399741015038 KMSKS motif; other site 399741015039 phosphoglycolate phosphatase; Provisional; Region: PRK13222 399741015040 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 399741015041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741015042 motif II; other site 399741015043 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 399741015044 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 399741015045 substrate binding site [chemical binding]; other site 399741015046 hexamer interface [polypeptide binding]; other site 399741015047 metal binding site [ion binding]; metal-binding site 399741015048 DNA adenine methylase; Provisional; Region: PRK10904 399741015049 hypothetical protein; Reviewed; Region: PRK11901 399741015050 cell division protein DamX; Validated; Region: PRK10905 399741015051 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 399741015052 active site 399741015053 dimer interface [polypeptide binding]; other site 399741015054 metal binding site [ion binding]; metal-binding site 399741015055 shikimate kinase; Reviewed; Region: aroK; PRK00131 399741015056 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 399741015057 ADP binding site [chemical binding]; other site 399741015058 magnesium binding site [ion binding]; other site 399741015059 putative shikimate binding site; other site 399741015060 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 399741015061 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 399741015062 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 399741015063 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 399741015064 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 399741015065 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 399741015066 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 399741015067 Transglycosylase; Region: Transgly; pfam00912 399741015068 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 399741015069 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 399741015070 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 399741015071 ADP-ribose binding site [chemical binding]; other site 399741015072 dimer interface [polypeptide binding]; other site 399741015073 active site 399741015074 nudix motif; other site 399741015075 metal binding site [ion binding]; metal-binding site 399741015076 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 399741015077 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 399741015078 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741015079 motif II; other site 399741015080 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 399741015081 RNA binding surface [nucleotide binding]; other site 399741015082 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 399741015083 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 399741015084 dimerization interface [polypeptide binding]; other site 399741015085 domain crossover interface; other site 399741015086 redox-dependent activation switch; other site 399741015087 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 399741015088 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 399741015089 active site 399741015090 substrate-binding site [chemical binding]; other site 399741015091 metal-binding site [ion binding] 399741015092 ATP binding site [chemical binding]; other site 399741015093 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 399741015094 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 399741015095 oligomeric interface; other site 399741015096 putative active site [active] 399741015097 homodimer interface [polypeptide binding]; other site 399741015098 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 399741015099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 399741015100 dimerization interface [polypeptide binding]; other site 399741015101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741015102 dimer interface [polypeptide binding]; other site 399741015103 phosphorylation site [posttranslational modification] 399741015104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741015105 ATP binding site [chemical binding]; other site 399741015106 G-X-G motif; other site 399741015107 osmolarity response regulator; Provisional; Region: ompR; PRK09468 399741015108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741015109 active site 399741015110 phosphorylation site [posttranslational modification] 399741015111 intermolecular recognition site; other site 399741015112 dimerization interface [polypeptide binding]; other site 399741015113 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741015114 DNA binding site [nucleotide binding] 399741015115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741015116 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741015117 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 399741015118 substrate binding pocket [chemical binding]; other site 399741015119 dimerization interface [polypeptide binding]; other site 399741015120 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 399741015121 Pseudomonas putida aldehyde dehydrogenase PsfA (ACA09737)-like; Region: ALDH_PsfA-ACA09737; cd07120 399741015122 NAD(P) binding site [chemical binding]; other site 399741015123 catalytic residues [active] 399741015124 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 399741015125 Cupin domain; Region: Cupin_2; pfam07883 399741015126 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 399741015127 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 399741015128 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 399741015129 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 399741015130 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 399741015131 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 399741015132 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 399741015133 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 399741015134 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 399741015135 RNA binding site [nucleotide binding]; other site 399741015136 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 399741015137 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 399741015138 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 399741015139 G1 box; other site 399741015140 GTP/Mg2+ binding site [chemical binding]; other site 399741015141 Switch I region; other site 399741015142 G2 box; other site 399741015143 G3 box; other site 399741015144 Switch II region; other site 399741015145 G4 box; other site 399741015146 G5 box; other site 399741015147 Nucleoside recognition; Region: Gate; pfam07670 399741015148 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 399741015149 Nucleoside recognition; Region: Gate; pfam07670 399741015150 FeoC like transcriptional regulator; Region: FeoC; cl17677 399741015151 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 399741015152 carboxylesterase BioH; Provisional; Region: PRK10349 399741015153 DNA utilization protein GntX; Provisional; Region: PRK11595 399741015154 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 399741015155 active site 399741015156 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 399741015157 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 399741015158 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 399741015159 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 399741015160 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 399741015161 maltodextrin phosphorylase; Provisional; Region: PRK14985 399741015162 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 399741015163 active site pocket [active] 399741015164 transcriptional regulator MalT; Provisional; Region: PRK04841 399741015165 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741015166 DNA binding residues [nucleotide binding] 399741015167 dimerization interface [polypeptide binding]; other site 399741015168 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 399741015169 active site residue [active] 399741015170 intramembrane serine protease GlpG; Provisional; Region: PRK10907 399741015171 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 399741015172 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 399741015173 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 399741015174 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 399741015175 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 399741015176 Virulence protein [General function prediction only]; Region: COG3943 399741015177 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 399741015178 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 399741015179 hydroxyglutarate oxidase; Provisional; Region: PRK11728 399741015180 glycogen phosphorylase; Provisional; Region: PRK14986 399741015181 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 399741015182 homodimer interface [polypeptide binding]; other site 399741015183 active site pocket [active] 399741015184 glycogen synthase; Provisional; Region: glgA; PRK00654 399741015185 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 399741015186 ADP-binding pocket [chemical binding]; other site 399741015187 homodimer interface [polypeptide binding]; other site 399741015188 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 399741015189 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 399741015190 ligand binding site; other site 399741015191 oligomer interface; other site 399741015192 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 399741015193 sulfate 1 binding site; other site 399741015194 glycogen debranching enzyme; Provisional; Region: PRK03705 399741015195 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 399741015196 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 399741015197 active site 399741015198 catalytic site [active] 399741015199 glycogen branching enzyme; Provisional; Region: PRK05402 399741015200 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 399741015201 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 399741015202 active site 399741015203 catalytic site [active] 399741015204 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 399741015205 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 399741015206 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 399741015207 putative antibiotic transporter; Provisional; Region: PRK10739 399741015208 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 399741015209 AAA domain; Region: AAA_33; pfam13671 399741015210 ATP-binding site [chemical binding]; other site 399741015211 Gluconate-6-phosphate binding site [chemical binding]; other site 399741015212 high-affinity gluconate transporter; Provisional; Region: PRK14984 399741015213 gluconate transporter; Region: gntP; TIGR00791 399741015214 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 399741015215 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741015216 DNA binding site [nucleotide binding] 399741015217 domain linker motif; other site 399741015218 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 399741015219 putative ligand binding site [chemical binding]; other site 399741015220 putative dimerization interface [polypeptide binding]; other site 399741015221 Pirin-related protein [General function prediction only]; Region: COG1741 399741015222 Pirin; Region: Pirin; pfam02678 399741015223 putative acetyltransferase YhhY; Provisional; Region: PRK10140 399741015224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741015225 Coenzyme A binding pocket [chemical binding]; other site 399741015226 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 399741015227 putative active site pocket [active] 399741015228 cleavage site 399741015229 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 399741015230 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 399741015231 Metal-binding active site; metal-binding site 399741015232 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 399741015233 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 399741015234 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 399741015235 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 399741015236 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 399741015237 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 399741015238 PYR/PP interface [polypeptide binding]; other site 399741015239 dimer interface [polypeptide binding]; other site 399741015240 TPP binding site [chemical binding]; other site 399741015241 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 399741015242 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 399741015243 TPP-binding site; other site 399741015244 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 399741015245 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 399741015246 substrate binding site [chemical binding]; other site 399741015247 ATP binding site [chemical binding]; other site 399741015248 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 399741015249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 399741015250 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 399741015251 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 399741015252 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 399741015253 putative active site [active] 399741015254 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 399741015255 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 399741015256 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 399741015257 tetrameric interface [polypeptide binding]; other site 399741015258 NAD binding site [chemical binding]; other site 399741015259 catalytic residues [active] 399741015260 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 399741015261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741015262 putative substrate translocation pore; other site 399741015263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741015264 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 399741015265 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 399741015266 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 399741015267 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 399741015268 Walker A/P-loop; other site 399741015269 ATP binding site [chemical binding]; other site 399741015270 Q-loop/lid; other site 399741015271 ABC transporter signature motif; other site 399741015272 Walker B; other site 399741015273 D-loop; other site 399741015274 H-loop/switch region; other site 399741015275 FaeA-like protein; Region: FaeA; pfam04703 399741015276 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 399741015277 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 399741015278 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 399741015279 Fimbrial protein; Region: Fimbrial; cl01416 399741015280 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 399741015281 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 399741015282 PapC N-terminal domain; Region: PapC_N; pfam13954 399741015283 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 399741015284 PapC C-terminal domain; Region: PapC_C; pfam13953 399741015285 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 399741015286 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 399741015287 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 399741015288 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 399741015289 Fimbrial protein; Region: Fimbrial; cl01416 399741015290 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 399741015291 O-Antigen ligase; Region: Wzy_C; pfam04932 399741015292 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 399741015293 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 399741015294 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 399741015295 DNA binding residues [nucleotide binding] 399741015296 dimerization interface [polypeptide binding]; other site 399741015297 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 399741015298 Amidinotransferase; Region: Amidinotransf; pfam02274 399741015299 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 399741015300 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 399741015301 putative DNA binding site [nucleotide binding]; other site 399741015302 putative Zn2+ binding site [ion binding]; other site 399741015303 AsnC family; Region: AsnC_trans_reg; pfam01037 399741015304 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 399741015305 classical (c) SDRs; Region: SDR_c; cd05233 399741015306 NAD(P) binding site [chemical binding]; other site 399741015307 active site 399741015308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741015309 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741015310 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 399741015311 putative effector binding pocket; other site 399741015312 dimerization interface [polypeptide binding]; other site 399741015313 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 399741015314 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 399741015315 active site 399741015316 FMN binding site [chemical binding]; other site 399741015317 substrate binding site [chemical binding]; other site 399741015318 putative catalytic residue [active] 399741015319 SnoaL-like domain; Region: SnoaL_2; pfam12680 399741015320 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 399741015321 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741015322 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741015323 Predicted flavoproteins [General function prediction only]; Region: COG2081 399741015324 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 399741015325 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 399741015326 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 399741015327 universal stress protein UspB; Provisional; Region: PRK04960 399741015328 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 399741015329 Ligand Binding Site [chemical binding]; other site 399741015330 glutamate dehydrogenase; Provisional; Region: PRK09414 399741015331 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 399741015332 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 399741015333 NAD(P) binding site [chemical binding]; other site 399741015334 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 399741015335 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 399741015336 ligand binding site [chemical binding]; other site 399741015337 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 399741015338 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 399741015339 Walker A/P-loop; other site 399741015340 ATP binding site [chemical binding]; other site 399741015341 Q-loop/lid; other site 399741015342 ABC transporter signature motif; other site 399741015343 Walker B; other site 399741015344 D-loop; other site 399741015345 H-loop/switch region; other site 399741015346 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 399741015347 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 399741015348 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 399741015349 TM-ABC transporter signature motif; other site 399741015350 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 399741015351 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 399741015352 TM-ABC transporter signature motif; other site 399741015353 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 399741015354 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 399741015355 N- and C-terminal domain interface [polypeptide binding]; other site 399741015356 active site 399741015357 MgATP binding site [chemical binding]; other site 399741015358 catalytic site [active] 399741015359 metal binding site [ion binding]; metal-binding site 399741015360 carbohydrate binding site [chemical binding]; other site 399741015361 putative homodimer interface [polypeptide binding]; other site 399741015362 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 399741015363 putative active site [active] 399741015364 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 399741015365 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 399741015366 active site 399741015367 metal binding site [ion binding]; metal-binding site 399741015368 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 399741015369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741015370 S-adenosylmethionine binding site [chemical binding]; other site 399741015371 oligopeptidase A; Provisional; Region: PRK10911 399741015372 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 399741015373 active site 399741015374 Zn binding site [ion binding]; other site 399741015375 Transcriptional regulators [Transcription]; Region: GntR; COG1802 399741015376 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741015377 DNA-binding site [nucleotide binding]; DNA binding site 399741015378 FCD domain; Region: FCD; pfam07729 399741015379 DctM-like transporters; Region: DctM; pfam06808 399741015380 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 399741015381 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 399741015382 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 399741015383 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 399741015384 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 399741015385 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 399741015386 putative NAD(P) binding site [chemical binding]; other site 399741015387 catalytic Zn binding site [ion binding]; other site 399741015388 structural Zn binding site [ion binding]; other site 399741015389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 399741015390 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 399741015391 NAD(P) binding site [chemical binding]; other site 399741015392 active site 399741015393 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 399741015394 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 399741015395 active site pocket [active] 399741015396 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 399741015397 nucleotide binding site/active site [active] 399741015398 HIT family signature motif; other site 399741015399 catalytic residue [active] 399741015400 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 399741015401 Amidase; Region: Amidase; cl11426 399741015402 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741015403 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741015404 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 399741015405 putative substrate binding pocket [chemical binding]; other site 399741015406 putative dimerization interface [polypeptide binding]; other site 399741015407 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 399741015408 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 399741015409 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 399741015410 glutathione reductase; Validated; Region: PRK06116 399741015411 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 399741015412 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 399741015413 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 399741015414 O-Antigen ligase; Region: Wzy_C; pfam04932 399741015415 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 399741015416 Fimbrial protein; Region: Fimbrial; cl01416 399741015417 Fimbrial protein; Region: Fimbrial; cl01416 399741015418 Fimbrial protein; Region: Fimbrial; pfam00419 399741015419 PapG chaperone-binding domain; Region: PapG_C; pfam03628 399741015420 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 399741015421 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 399741015422 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 399741015423 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 399741015424 PapC N-terminal domain; Region: PapC_N; pfam13954 399741015425 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 399741015426 PapC C-terminal domain; Region: PapC_C; pfam13953 399741015427 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 399741015428 Fimbrial protein; Region: Fimbrial; cl01416 399741015429 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 399741015430 DNA binding site [nucleotide binding] 399741015431 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 399741015432 DNA binding site [nucleotide binding] 399741015433 haemagglutination activity domain; Region: Haemagg_act; pfam05860 399741015434 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 399741015435 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 399741015436 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 399741015437 DinB family; Region: DinB; cl17821 399741015438 DinB superfamily; Region: DinB_2; pfam12867 399741015439 Cupin; Region: Cupin_6; pfam12852 399741015440 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741015441 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 399741015442 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 399741015443 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 399741015444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741015445 dimer interface [polypeptide binding]; other site 399741015446 phosphorylation site [posttranslational modification] 399741015447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741015448 ATP binding site [chemical binding]; other site 399741015449 Mg2+ binding site [ion binding]; other site 399741015450 G-X-G motif; other site 399741015451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741015452 active site 399741015453 phosphorylation site [posttranslational modification] 399741015454 intermolecular recognition site; other site 399741015455 dimerization interface [polypeptide binding]; other site 399741015456 BetR domain; Region: BetR; pfam08667 399741015457 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 399741015458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 399741015459 active site 399741015460 phosphorylation site [posttranslational modification] 399741015461 intermolecular recognition site; other site 399741015462 dimerization interface [polypeptide binding]; other site 399741015463 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 399741015464 catalytic triad [active] 399741015465 putative active site [active] 399741015466 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 399741015467 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 399741015468 Autotransporter beta-domain; Region: Autotransporter; pfam03797 399741015469 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 399741015470 catalytic triad [active] 399741015471 putative active site [active] 399741015472 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 399741015473 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 399741015474 Autotransporter beta-domain; Region: Autotransporter; pfam03797 399741015475 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 399741015476 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741015477 hypothetical protein; Provisional; Region: PRK02399 399741015478 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 399741015479 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 399741015480 dimer interface [polypeptide binding]; other site 399741015481 RNase II stability modulator; Provisional; Region: PRK10060 399741015482 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 399741015483 putative active site [active] 399741015484 heme pocket [chemical binding]; other site 399741015485 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 399741015486 metal binding site [ion binding]; metal-binding site 399741015487 active site 399741015488 I-site; other site 399741015489 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 399741015490 enoyl-CoA hydratase; Validated; Region: PRK08788 399741015491 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 399741015492 substrate binding site [chemical binding]; other site 399741015493 oxyanion hole (OAH) forming residues; other site 399741015494 trimer interface [polypeptide binding]; other site 399741015495 inner membrane protein YhjD; Region: TIGR00766 399741015496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741015497 metabolite-proton symporter; Region: 2A0106; TIGR00883 399741015498 putative substrate translocation pore; other site 399741015499 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 399741015500 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 399741015501 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 399741015502 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 399741015503 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 399741015504 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 399741015505 active site 1 [active] 399741015506 dimer interface [polypeptide binding]; other site 399741015507 hexamer interface [polypeptide binding]; other site 399741015508 active site 2 [active] 399741015509 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 399741015510 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 399741015511 substrate binding site [chemical binding]; other site 399741015512 ATP binding site [chemical binding]; other site 399741015513 ketol-acid reductoisomerase; Validated; Region: PRK05225 399741015514 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 399741015515 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 399741015516 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 399741015517 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741015518 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 399741015519 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 399741015520 putative dimerization interface [polypeptide binding]; other site 399741015521 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 399741015522 threonine dehydratase; Reviewed; Region: PRK09224 399741015523 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 399741015524 tetramer interface [polypeptide binding]; other site 399741015525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741015526 catalytic residue [active] 399741015527 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 399741015528 putative Ile/Val binding site [chemical binding]; other site 399741015529 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 399741015530 putative Ile/Val binding site [chemical binding]; other site 399741015531 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 399741015532 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 399741015533 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 399741015534 homodimer interface [polypeptide binding]; other site 399741015535 substrate-cofactor binding pocket; other site 399741015536 catalytic residue [active] 399741015537 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 399741015538 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 399741015539 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 399741015540 PYR/PP interface [polypeptide binding]; other site 399741015541 dimer interface [polypeptide binding]; other site 399741015542 TPP binding site [chemical binding]; other site 399741015543 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 399741015544 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 399741015545 TPP-binding site [chemical binding]; other site 399741015546 dimer interface [polypeptide binding]; other site 399741015547 putative sialic acid transporter; Region: 2A0112; TIGR00891 399741015548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741015549 putative substrate translocation pore; other site 399741015550 putative ATP-dependent protease; Provisional; Region: PRK09862 399741015551 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 399741015552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741015553 Walker A motif; other site 399741015554 ATP binding site [chemical binding]; other site 399741015555 Walker B motif; other site 399741015556 arginine finger; other site 399741015557 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 399741015558 hypothetical protein; Provisional; Region: PRK11027 399741015559 transcriptional regulator HdfR; Provisional; Region: PRK03601 399741015560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741015561 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 399741015562 dimerization interface [polypeptide binding]; other site 399741015563 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 399741015564 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 399741015565 TM-ABC transporter signature motif; other site 399741015566 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 399741015567 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 399741015568 TM-ABC transporter signature motif; other site 399741015569 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 399741015570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 399741015571 Walker A/P-loop; other site 399741015572 ATP binding site [chemical binding]; other site 399741015573 Q-loop/lid; other site 399741015574 ABC transporter signature motif; other site 399741015575 Walker B; other site 399741015576 D-loop; other site 399741015577 H-loop/switch region; other site 399741015578 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 399741015579 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 399741015580 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 399741015581 putative ligand binding site [chemical binding]; other site 399741015582 glutamate racemase; Provisional; Region: PRK00865 399741015583 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 399741015584 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 399741015585 N-terminal plug; other site 399741015586 ligand-binding site [chemical binding]; other site 399741015587 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 399741015588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741015589 S-adenosylmethionine binding site [chemical binding]; other site 399741015590 hypothetical protein; Provisional; Region: PRK11056 399741015591 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 399741015592 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741015593 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 399741015594 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 399741015595 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 399741015596 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 399741015597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741015598 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 399741015599 dimerization interface [polypeptide binding]; other site 399741015600 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 399741015601 catalytic triad [active] 399741015602 dimer interface [polypeptide binding]; other site 399741015603 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 399741015604 GSH binding site [chemical binding]; other site 399741015605 catalytic residues [active] 399741015606 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 399741015607 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 399741015608 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 399741015609 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 399741015610 argininosuccinate lyase; Provisional; Region: PRK04833 399741015611 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 399741015612 active sites [active] 399741015613 tetramer interface [polypeptide binding]; other site 399741015614 argininosuccinate synthase; Provisional; Region: PRK13820 399741015615 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 399741015616 ANP binding site [chemical binding]; other site 399741015617 Substrate Binding Site II [chemical binding]; other site 399741015618 Substrate Binding Site I [chemical binding]; other site 399741015619 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 399741015620 nucleotide binding site [chemical binding]; other site 399741015621 N-acetyl-L-glutamate binding site [chemical binding]; other site 399741015622 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 399741015623 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 399741015624 acetylornithine deacetylase; Provisional; Region: PRK05111 399741015625 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 399741015626 metal binding site [ion binding]; metal-binding site 399741015627 putative dimer interface [polypeptide binding]; other site 399741015628 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 399741015629 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 399741015630 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 399741015631 FAD binding site [chemical binding]; other site 399741015632 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 399741015633 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 399741015634 putative catalytic residues [active] 399741015635 putative nucleotide binding site [chemical binding]; other site 399741015636 putative aspartate binding site [chemical binding]; other site 399741015637 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 399741015638 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 399741015639 cystathionine gamma-synthase; Provisional; Region: PRK08045 399741015640 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 399741015641 homodimer interface [polypeptide binding]; other site 399741015642 substrate-cofactor binding pocket; other site 399741015643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741015644 catalytic residue [active] 399741015645 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 399741015646 dimerization interface [polypeptide binding]; other site 399741015647 DNA binding site [nucleotide binding] 399741015648 corepressor binding sites; other site 399741015649 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 399741015650 primosome assembly protein PriA; Validated; Region: PRK05580 399741015651 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 399741015652 ATP binding site [chemical binding]; other site 399741015653 putative Mg++ binding site [ion binding]; other site 399741015654 helicase superfamily c-terminal domain; Region: HELICc; smart00490 399741015655 ATP-binding site [chemical binding]; other site 399741015656 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741015657 DNA binding site [nucleotide binding] 399741015658 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 399741015659 domain linker motif; other site 399741015660 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 399741015661 dimerization interface [polypeptide binding]; other site 399741015662 ligand binding site [chemical binding]; other site 399741015663 Sporulation related domain; Region: SPOR; cl10051 399741015664 cell division protein FtsN; Provisional; Region: PRK12757 399741015665 Sporulation related domain; Region: SPOR; cl10051 399741015666 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 399741015667 active site 399741015668 HslU subunit interaction site [polypeptide binding]; other site 399741015669 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 399741015670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741015671 Walker A motif; other site 399741015672 ATP binding site [chemical binding]; other site 399741015673 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 399741015674 Walker B motif; other site 399741015675 arginine finger; other site 399741015676 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 399741015677 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 399741015678 UbiA prenyltransferase family; Region: UbiA; pfam01040 399741015679 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 399741015680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 399741015681 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 399741015682 amphipathic channel; other site 399741015683 Asn-Pro-Ala signature motifs; other site 399741015684 glycerol kinase; Provisional; Region: glpK; PRK00047 399741015685 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 399741015686 N- and C-terminal domain interface [polypeptide binding]; other site 399741015687 active site 399741015688 MgATP binding site [chemical binding]; other site 399741015689 catalytic site [active] 399741015690 metal binding site [ion binding]; metal-binding site 399741015691 glycerol binding site [chemical binding]; other site 399741015692 homotetramer interface [polypeptide binding]; other site 399741015693 homodimer interface [polypeptide binding]; other site 399741015694 FBP binding site [chemical binding]; other site 399741015695 protein IIAGlc interface [polypeptide binding]; other site 399741015696 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 399741015697 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 399741015698 putative active site [active] 399741015699 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 399741015700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741015701 putative substrate translocation pore; other site 399741015702 Predicted transcriptional regulator [Transcription]; Region: COG2345 399741015703 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 399741015704 ferredoxin-NADP reductase; Provisional; Region: PRK10926 399741015705 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 399741015706 FAD binding pocket [chemical binding]; other site 399741015707 FAD binding motif [chemical binding]; other site 399741015708 phosphate binding motif [ion binding]; other site 399741015709 beta-alpha-beta structure motif; other site 399741015710 NAD binding pocket [chemical binding]; other site 399741015711 Predicted membrane protein [Function unknown]; Region: COG3152 399741015712 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 399741015713 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 399741015714 triosephosphate isomerase; Provisional; Region: PRK14567 399741015715 substrate binding site [chemical binding]; other site 399741015716 dimer interface [polypeptide binding]; other site 399741015717 catalytic triad [active] 399741015718 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 399741015719 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 399741015720 substrate binding pocket [chemical binding]; other site 399741015721 membrane-bound complex binding site; other site 399741015722 hinge residues; other site 399741015723 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 399741015724 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 399741015725 active site 399741015726 ADP/pyrophosphate binding site [chemical binding]; other site 399741015727 dimerization interface [polypeptide binding]; other site 399741015728 allosteric effector site; other site 399741015729 fructose-1,6-bisphosphate binding site; other site 399741015730 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 399741015731 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 399741015732 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 399741015733 dimer interface [polypeptide binding]; other site 399741015734 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 399741015735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741015736 active site 399741015737 phosphorylation site [posttranslational modification] 399741015738 intermolecular recognition site; other site 399741015739 dimerization interface [polypeptide binding]; other site 399741015740 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 399741015741 DNA binding site [nucleotide binding] 399741015742 two-component sensor protein; Provisional; Region: cpxA; PRK09470 399741015743 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 399741015744 dimerization interface [polypeptide binding]; other site 399741015745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741015746 dimer interface [polypeptide binding]; other site 399741015747 phosphorylation site [posttranslational modification] 399741015748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741015749 ATP binding site [chemical binding]; other site 399741015750 Mg2+ binding site [ion binding]; other site 399741015751 G-X-G motif; other site 399741015752 putative rRNA methylase; Provisional; Region: PRK10358 399741015753 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 399741015754 serine acetyltransferase; Provisional; Region: cysE; PRK11132 399741015755 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 399741015756 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 399741015757 trimer interface [polypeptide binding]; other site 399741015758 active site 399741015759 substrate binding site [chemical binding]; other site 399741015760 CoA binding site [chemical binding]; other site 399741015761 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 399741015762 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 399741015763 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 399741015764 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 399741015765 SecA binding site; other site 399741015766 Preprotein binding site; other site 399741015767 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 399741015768 GSH binding site [chemical binding]; other site 399741015769 catalytic residues [active] 399741015770 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 399741015771 active site residue [active] 399741015772 phosphoglyceromutase; Provisional; Region: PRK05434 399741015773 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 399741015774 AmiB activator; Provisional; Region: PRK11637 399741015775 Peptidase family M23; Region: Peptidase_M23; pfam01551 399741015776 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 399741015777 NodB motif; other site 399741015778 putative active site [active] 399741015779 putative catalytic site [active] 399741015780 Zn binding site [ion binding]; other site 399741015781 arginine decarboxylase; Provisional; Region: PRK15029 399741015782 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 399741015783 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 399741015784 homodimer interface [polypeptide binding]; other site 399741015785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741015786 catalytic residue [active] 399741015787 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 399741015788 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 399741015789 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 399741015790 NAD(P) binding site [chemical binding]; other site 399741015791 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 399741015792 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 399741015793 substrate-cofactor binding pocket; other site 399741015794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 399741015795 catalytic residue [active] 399741015796 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 399741015797 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 399741015798 NADP binding site [chemical binding]; other site 399741015799 homopentamer interface [polypeptide binding]; other site 399741015800 substrate binding site [chemical binding]; other site 399741015801 active site 399741015802 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 399741015803 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 399741015804 putative active site [active] 399741015805 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 399741015806 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 399741015807 putative active site [active] 399741015808 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 399741015809 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 399741015810 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 399741015811 putative active site [active] 399741015812 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 399741015813 putative active site [active] 399741015814 putative catalytic site [active] 399741015815 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 399741015816 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 399741015817 putative active site [active] 399741015818 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 399741015819 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 399741015820 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 399741015821 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 399741015822 putative ADP-binding pocket [chemical binding]; other site 399741015823 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 399741015824 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 399741015825 putative active site [active] 399741015826 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 399741015827 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 399741015828 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 399741015829 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 399741015830 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 399741015831 putative metal binding site; other site 399741015832 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 399741015833 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 399741015834 active site 399741015835 (T/H)XGH motif; other site 399741015836 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 399741015837 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 399741015838 DNA binding site [nucleotide binding] 399741015839 catalytic residue [active] 399741015840 H2TH interface [polypeptide binding]; other site 399741015841 putative catalytic residues [active] 399741015842 turnover-facilitating residue; other site 399741015843 intercalation triad [nucleotide binding]; other site 399741015844 8OG recognition residue [nucleotide binding]; other site 399741015845 putative reading head residues; other site 399741015846 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 399741015847 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 399741015848 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 399741015849 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 399741015850 hypothetical protein; Reviewed; Region: PRK00024 399741015851 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 399741015852 MPN+ (JAMM) motif; other site 399741015853 Zinc-binding site [ion binding]; other site 399741015854 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 399741015855 Flavoprotein; Region: Flavoprotein; pfam02441 399741015856 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 399741015857 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 399741015858 trimer interface [polypeptide binding]; other site 399741015859 active site 399741015860 division inhibitor protein; Provisional; Region: slmA; PRK09480 399741015861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741015862 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 399741015863 active site 399741015864 ribonuclease PH; Reviewed; Region: rph; PRK00173 399741015865 Ribonuclease PH; Region: RNase_PH_bact; cd11362 399741015866 hexamer interface [polypeptide binding]; other site 399741015867 active site 399741015868 hypothetical protein; Provisional; Region: PRK11820 399741015869 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 399741015870 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 399741015871 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 399741015872 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 399741015873 Trp docking motif [polypeptide binding]; other site 399741015874 putative active site [active] 399741015875 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 399741015876 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 399741015877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 399741015878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 399741015879 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 399741015880 Paraquat-inducible protein A; Region: PqiA; pfam04403 399741015881 Paraquat-inducible protein A; Region: PqiA; pfam04403 399741015882 paraquat-inducible protein B; Provisional; Region: PRK10807 399741015883 mce related protein; Region: MCE; pfam02470 399741015884 mce related protein; Region: MCE; pfam02470 399741015885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 399741015886 Protein of unknown function (DUF330); Region: DUF330; pfam03886 399741015887 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 399741015888 Strictosidine synthase; Region: Str_synth; pfam03088 399741015889 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741015890 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741015891 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 399741015892 putative effector binding pocket; other site 399741015893 dimerization interface [polypeptide binding]; other site 399741015894 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 399741015895 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 399741015896 dimer interface [polypeptide binding]; other site 399741015897 active site 399741015898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 399741015899 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 399741015900 NAD(P) binding site [chemical binding]; other site 399741015901 active site 399741015902 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 399741015903 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 399741015904 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 399741015905 acyl-activating enzyme (AAE) consensus motif; other site 399741015906 acyl-activating enzyme (AAE) consensus motif; other site 399741015907 putative AMP binding site [chemical binding]; other site 399741015908 putative active site [active] 399741015909 putative CoA binding site [chemical binding]; other site 399741015910 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 399741015911 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 399741015912 Nucleoside recognition; Region: Gate; pfam07670 399741015913 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 399741015914 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 399741015915 Predicted membrane protein [Function unknown]; Region: COG2860 399741015916 UPF0126 domain; Region: UPF0126; pfam03458 399741015917 UPF0126 domain; Region: UPF0126; pfam03458 399741015918 Transcriptional regulator [Transcription]; Region: LysR; COG0583 399741015919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 399741015920 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 399741015921 putative effector binding pocket; other site 399741015922 putative dimerization interface [polypeptide binding]; other site 399741015923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741015924 Major Facilitator Superfamily; Region: MFS_1; pfam07690 399741015925 putative substrate translocation pore; other site 399741015926 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 399741015927 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 399741015928 catalytic site [active] 399741015929 G-X2-G-X-G-K; other site 399741015930 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 399741015931 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 399741015932 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 399741015933 Zn2+ binding site [ion binding]; other site 399741015934 Mg2+ binding site [ion binding]; other site 399741015935 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 399741015936 synthetase active site [active] 399741015937 NTP binding site [chemical binding]; other site 399741015938 metal binding site [ion binding]; metal-binding site 399741015939 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 399741015940 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 399741015941 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 399741015942 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 399741015943 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 399741015944 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 399741015945 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 399741015946 generic binding surface II; other site 399741015947 ssDNA binding site; other site 399741015948 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 399741015949 ATP binding site [chemical binding]; other site 399741015950 putative Mg++ binding site [ion binding]; other site 399741015951 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 399741015952 nucleotide binding region [chemical binding]; other site 399741015953 ATP-binding site [chemical binding]; other site 399741015954 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 399741015955 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 399741015956 AsmA family; Region: AsmA; pfam05170 399741015957 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 399741015958 putative active site [active] 399741015959 putative catalytic triad [active] 399741015960 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 399741015961 aromatic chitin/cellulose binding site residues [chemical binding]; other site 399741015962 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 399741015963 Coenzyme A binding pocket [chemical binding]; other site 399741015964 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 399741015965 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 399741015966 putative active site [active] 399741015967 dimerization interface [polypeptide binding]; other site 399741015968 putative tRNAtyr binding site [nucleotide binding]; other site 399741015969 hypothetical protein; Reviewed; Region: PRK01637 399741015970 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 399741015971 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 399741015972 motif II; other site 399741015973 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 399741015974 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 399741015975 G1 box; other site 399741015976 putative GEF interaction site [polypeptide binding]; other site 399741015977 GTP/Mg2+ binding site [chemical binding]; other site 399741015978 Switch I region; other site 399741015979 G2 box; other site 399741015980 G3 box; other site 399741015981 Switch II region; other site 399741015982 G4 box; other site 399741015983 G5 box; other site 399741015984 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 399741015985 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 399741015986 glutamine synthetase; Provisional; Region: glnA; PRK09469 399741015987 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 399741015988 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 399741015989 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 399741015990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 399741015991 dimer interface [polypeptide binding]; other site 399741015992 phosphorylation site [posttranslational modification] 399741015993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 399741015994 ATP binding site [chemical binding]; other site 399741015995 Mg2+ binding site [ion binding]; other site 399741015996 G-X-G motif; other site 399741015997 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 399741015998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 399741015999 active site 399741016000 phosphorylation site [posttranslational modification] 399741016001 intermolecular recognition site; other site 399741016002 dimerization interface [polypeptide binding]; other site 399741016003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741016004 Walker A motif; other site 399741016005 ATP binding site [chemical binding]; other site 399741016006 Walker B motif; other site 399741016007 arginine finger; other site 399741016008 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 399741016009 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 399741016010 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 399741016011 FeS/SAM binding site; other site 399741016012 HemN C-terminal domain; Region: HemN_C; pfam06969 399741016013 Der GTPase activator; Provisional; Region: PRK05244 399741016014 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 399741016015 G1 box; other site 399741016016 GTP/Mg2+ binding site [chemical binding]; other site 399741016017 Switch I region; other site 399741016018 G2 box; other site 399741016019 G3 box; other site 399741016020 Switch II region; other site 399741016021 G4 box; other site 399741016022 G5 box; other site 399741016023 DNA polymerase I; Provisional; Region: PRK05755 399741016024 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 399741016025 active site 399741016026 metal binding site 1 [ion binding]; metal-binding site 399741016027 putative 5' ssDNA interaction site; other site 399741016028 metal binding site 3; metal-binding site 399741016029 metal binding site 2 [ion binding]; metal-binding site 399741016030 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 399741016031 putative DNA binding site [nucleotide binding]; other site 399741016032 putative metal binding site [ion binding]; other site 399741016033 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 399741016034 active site 399741016035 catalytic site [active] 399741016036 substrate binding site [chemical binding]; other site 399741016037 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 399741016038 active site 399741016039 DNA binding site [nucleotide binding] 399741016040 catalytic site [active] 399741016041 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 399741016042 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 399741016043 putative acyl-acceptor binding pocket; other site 399741016044 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 399741016045 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 399741016046 catalytic residues [active] 399741016047 hinge region; other site 399741016048 alpha helical domain; other site 399741016049 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 399741016050 serine/threonine protein kinase; Provisional; Region: PRK11768 399741016051 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 399741016052 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 399741016053 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 399741016054 GTP binding site; other site 399741016055 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 399741016056 Walker A motif; other site 399741016057 Transcriptional regulators [Transcription]; Region: FadR; COG2186 399741016058 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 399741016059 DNA-binding site [nucleotide binding]; DNA binding site 399741016060 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 399741016061 putative transporter; Provisional; Region: PRK10504 399741016062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 399741016063 putative substrate translocation pore; other site 399741016064 transcriptional repressor RbsR; Provisional; Region: PRK10423 399741016065 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 399741016066 DNA binding site [nucleotide binding] 399741016067 domain linker motif; other site 399741016068 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 399741016069 dimerization interface [polypeptide binding]; other site 399741016070 ligand binding site [chemical binding]; other site 399741016071 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 399741016072 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 399741016073 substrate binding site [chemical binding]; other site 399741016074 dimer interface [polypeptide binding]; other site 399741016075 ATP binding site [chemical binding]; other site 399741016076 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 399741016077 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 399741016078 ligand binding site [chemical binding]; other site 399741016079 dimerization interface [polypeptide binding]; other site 399741016080 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 399741016081 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 399741016082 TM-ABC transporter signature motif; other site 399741016083 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 399741016084 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 399741016085 Walker A/P-loop; other site 399741016086 ATP binding site [chemical binding]; other site 399741016087 Q-loop/lid; other site 399741016088 ABC transporter signature motif; other site 399741016089 Walker B; other site 399741016090 D-loop; other site 399741016091 H-loop/switch region; other site 399741016092 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 399741016093 D-ribose pyranase; Provisional; Region: PRK11797 399741016094 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 399741016095 potassium uptake protein; Region: kup; TIGR00794 399741016096 regulatory ATPase RavA; Provisional; Region: PRK13531 399741016097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 399741016098 Walker A motif; other site 399741016099 ATP binding site [chemical binding]; other site 399741016100 Walker B motif; other site 399741016101 arginine finger; other site 399741016102 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 399741016103 hypothetical protein; Provisional; Region: yieM; PRK10997 399741016104 Phosphopantetheine attachment site; Region: PP-binding; cl09936 399741016105 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 399741016106 metal ion-dependent adhesion site (MIDAS); other site 399741016107 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 399741016108 motif 1; other site 399741016109 dimer interface [polypeptide binding]; other site 399741016110 active site 399741016111 motif 2; other site 399741016112 motif 3; other site 399741016113 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 399741016114 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 399741016115 dimerization interface [polypeptide binding]; other site 399741016116 putative DNA binding site [nucleotide binding]; other site 399741016117 putative Zn2+ binding site [ion binding]; other site 399741016118 AsnC family; Region: AsnC_trans_reg; pfam01037 399741016119 FMN-binding protein MioC; Provisional; Region: PRK09004 399741016120 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 399741016121 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 399741016122 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 399741016123 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 399741016124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 399741016125 S-adenosylmethionine binding site [chemical binding]; other site