-- dump date 20140620_062953 -- class Genbank::misc_feature -- table misc_feature_note -- id note 568817000001 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 568817000002 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 568817000003 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 568817000004 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 568817000005 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 568817000006 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 568817000007 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 568817000008 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 568817000009 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 568817000010 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 568817000011 beta subunit interaction interface [polypeptide binding]; other site 568817000012 Walker A motif; other site 568817000013 ATP binding site [chemical binding]; other site 568817000014 Walker B motif; other site 568817000015 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 568817000016 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 568817000017 core domain interface [polypeptide binding]; other site 568817000018 delta subunit interface [polypeptide binding]; other site 568817000019 epsilon subunit interface [polypeptide binding]; other site 568817000020 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 568817000021 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 568817000022 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 568817000023 alpha subunit interaction interface [polypeptide binding]; other site 568817000024 Walker A motif; other site 568817000025 ATP binding site [chemical binding]; other site 568817000026 Walker B motif; other site 568817000027 inhibitor binding site; inhibition site 568817000028 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 568817000029 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 568817000030 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 568817000031 gamma subunit interface [polypeptide binding]; other site 568817000032 epsilon subunit interface [polypeptide binding]; other site 568817000033 LBP interface [polypeptide binding]; other site 568817000034 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 568817000035 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 568817000036 Substrate binding site; other site 568817000037 Mg++ binding site; other site 568817000038 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 568817000039 active site 568817000040 substrate binding site [chemical binding]; other site 568817000041 CoA binding site [chemical binding]; other site 568817000042 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 568817000043 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 568817000044 glutaminase active site [active] 568817000045 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 568817000046 dimer interface [polypeptide binding]; other site 568817000047 active site 568817000048 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 568817000049 dimer interface [polypeptide binding]; other site 568817000050 active site 568817000051 FMN reductase; Validated; Region: fre; PRK08051 568817000052 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 568817000053 FAD binding pocket [chemical binding]; other site 568817000054 FAD binding motif [chemical binding]; other site 568817000055 phosphate binding motif [ion binding]; other site 568817000056 beta-alpha-beta structure motif; other site 568817000057 NAD binding pocket [chemical binding]; other site 568817000058 potassium transporter; Provisional; Region: PRK10750 568817000059 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 568817000060 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 568817000061 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 568817000062 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 568817000063 active site 568817000064 dimer interface [polypeptide binding]; other site 568817000065 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 568817000066 dimer interface [polypeptide binding]; other site 568817000067 active site 568817000068 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 568817000069 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 568817000070 putative acyl-acceptor binding pocket; other site 568817000071 glutathione synthetase; Provisional; Region: PRK05246 568817000072 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 568817000073 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 568817000074 hypothetical protein; Validated; Region: PRK00228 568817000075 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 568817000076 YGGT family; Region: YGGT; pfam02325 568817000077 YGGT family; Region: YGGT; pfam02325 568817000078 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 568817000079 HemN family oxidoreductase; Provisional; Region: PRK05660 568817000080 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 568817000081 FeS/SAM binding site; other site 568817000082 HemN C-terminal domain; Region: HemN_C; pfam06969 568817000083 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 568817000084 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 568817000085 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 568817000086 dimer interface [polypeptide binding]; other site 568817000087 motif 1; other site 568817000088 active site 568817000089 motif 2; other site 568817000090 motif 3; other site 568817000091 hypothetical protein; Provisional; Region: PRK11820 568817000092 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 568817000093 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 568817000094 ribonuclease PH; Reviewed; Region: rph; PRK00173 568817000095 Ribonuclease PH; Region: RNase_PH_bact; cd11362 568817000096 hexamer interface [polypeptide binding]; other site 568817000097 active site 568817000098 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568817000099 active site 568817000100 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 568817000101 trimer interface [polypeptide binding]; other site 568817000102 active site 568817000103 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 568817000104 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 568817000105 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 568817000106 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 568817000107 DNA binding site [nucleotide binding] 568817000108 catalytic residue [active] 568817000109 H2TH interface [polypeptide binding]; other site 568817000110 putative catalytic residues [active] 568817000111 turnover-facilitating residue; other site 568817000112 intercalation triad [nucleotide binding]; other site 568817000113 8OG recognition residue [nucleotide binding]; other site 568817000114 putative reading head residues; other site 568817000115 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 568817000116 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 568817000117 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 568817000118 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 568817000119 active site 568817000120 (T/H)XGH motif; other site 568817000121 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 568817000122 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 568817000123 putative metal binding site; other site 568817000124 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 568817000125 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 568817000126 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568817000127 superoxide dismutase; Provisional; Region: PRK10925 568817000128 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 568817000129 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 568817000130 serine acetyltransferase; Provisional; Region: cysE; PRK11132 568817000131 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 568817000132 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 568817000133 trimer interface [polypeptide binding]; other site 568817000134 active site 568817000135 substrate binding site [chemical binding]; other site 568817000136 CoA binding site [chemical binding]; other site 568817000137 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 568817000138 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 568817000139 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 568817000140 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 568817000141 SecA binding site; other site 568817000142 Preprotein binding site; other site 568817000143 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 568817000144 active site residue [active] 568817000145 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 568817000146 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 568817000147 NADP binding site [chemical binding]; other site 568817000148 homopentamer interface [polypeptide binding]; other site 568817000149 substrate binding site [chemical binding]; other site 568817000150 active site 568817000151 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 568817000152 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 568817000153 putative active site [active] 568817000154 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 568817000155 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 568817000156 putative active site [active] 568817000157 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 568817000158 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 568817000159 active site 568817000160 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568817000161 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 568817000162 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 568817000163 Ligand binding site; other site 568817000164 metal-binding site 568817000165 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 568817000166 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 568817000167 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 568817000168 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 568817000169 ATP binding site [chemical binding]; other site 568817000170 Mg++ binding site [ion binding]; other site 568817000171 motif III; other site 568817000172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568817000173 nucleotide binding region [chemical binding]; other site 568817000174 ATP-binding site [chemical binding]; other site 568817000175 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 568817000176 putative RNA binding site [nucleotide binding]; other site 568817000177 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 568817000178 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 568817000179 RNase E interface [polypeptide binding]; other site 568817000180 trimer interface [polypeptide binding]; other site 568817000181 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 568817000182 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 568817000183 RNase E interface [polypeptide binding]; other site 568817000184 trimer interface [polypeptide binding]; other site 568817000185 active site 568817000186 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 568817000187 putative nucleic acid binding region [nucleotide binding]; other site 568817000188 G-X-X-G motif; other site 568817000189 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 568817000190 RNA binding site [nucleotide binding]; other site 568817000191 domain interface; other site 568817000192 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 568817000193 16S/18S rRNA binding site [nucleotide binding]; other site 568817000194 S13e-L30e interaction site [polypeptide binding]; other site 568817000195 25S rRNA binding site [nucleotide binding]; other site 568817000196 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 568817000197 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 568817000198 RNA binding site [nucleotide binding]; other site 568817000199 active site 568817000200 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 568817000201 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 568817000202 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 568817000203 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 568817000204 translation initiation factor IF-2; Region: IF-2; TIGR00487 568817000205 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 568817000206 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 568817000207 G1 box; other site 568817000208 putative GEF interaction site [polypeptide binding]; other site 568817000209 GTP/Mg2+ binding site [chemical binding]; other site 568817000210 Switch I region; other site 568817000211 G2 box; other site 568817000212 G3 box; other site 568817000213 Switch II region; other site 568817000214 G4 box; other site 568817000215 G5 box; other site 568817000216 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 568817000217 Translation-initiation factor 2; Region: IF-2; pfam11987 568817000218 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 568817000219 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 568817000220 NusA N-terminal domain; Region: NusA_N; pfam08529 568817000221 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 568817000222 RNA binding site [nucleotide binding]; other site 568817000223 homodimer interface [polypeptide binding]; other site 568817000224 NusA-like KH domain; Region: KH_5; pfam13184 568817000225 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 568817000226 G-X-X-G motif; other site 568817000227 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 568817000228 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 568817000229 ribosome maturation protein RimP; Reviewed; Region: PRK00092 568817000230 hypothetical protein; Provisional; Region: PRK14641 568817000231 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 568817000232 putative oligomer interface [polypeptide binding]; other site 568817000233 putative RNA binding site [nucleotide binding]; other site 568817000234 Preprotein translocase SecG subunit; Region: SecG; pfam03840 568817000235 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 568817000236 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 568817000237 active site 568817000238 substrate binding site [chemical binding]; other site 568817000239 metal binding site [ion binding]; metal-binding site 568817000240 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 568817000241 dihydropteroate synthase; Region: DHPS; TIGR01496 568817000242 substrate binding pocket [chemical binding]; other site 568817000243 dimer interface [polypeptide binding]; other site 568817000244 inhibitor binding site; inhibition site 568817000245 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 568817000246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568817000247 Walker A motif; other site 568817000248 ATP binding site [chemical binding]; other site 568817000249 Walker B motif; other site 568817000250 arginine finger; other site 568817000251 Peptidase family M41; Region: Peptidase_M41; pfam01434 568817000252 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 568817000253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568817000254 S-adenosylmethionine binding site [chemical binding]; other site 568817000255 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 568817000256 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 568817000257 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 568817000258 GTPase CgtA; Reviewed; Region: obgE; PRK12298 568817000259 GTP1/OBG; Region: GTP1_OBG; pfam01018 568817000260 Obg GTPase; Region: Obg; cd01898 568817000261 G1 box; other site 568817000262 GTP/Mg2+ binding site [chemical binding]; other site 568817000263 Switch I region; other site 568817000264 G2 box; other site 568817000265 G3 box; other site 568817000266 Switch II region; other site 568817000267 G4 box; other site 568817000268 G5 box; other site 568817000269 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 568817000270 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 568817000271 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 568817000272 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 568817000273 dimer interface [polypeptide binding]; other site 568817000274 substrate binding site [chemical binding]; other site 568817000275 metal binding sites [ion binding]; metal-binding site 568817000276 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 568817000277 TrkA-N domain; Region: TrkA_N; pfam02254 568817000278 TrkA-C domain; Region: TrkA_C; pfam02080 568817000279 TrkA-N domain; Region: TrkA_N; pfam02254 568817000280 TrkA-C domain; Region: TrkA_C; pfam02080 568817000281 16S rRNA methyltransferase B; Provisional; Region: PRK10901 568817000282 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 568817000283 putative RNA binding site [nucleotide binding]; other site 568817000284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568817000285 S-adenosylmethionine binding site [chemical binding]; other site 568817000286 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 568817000287 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 568817000288 putative active site [active] 568817000289 substrate binding site [chemical binding]; other site 568817000290 putative cosubstrate binding site; other site 568817000291 catalytic site [active] 568817000292 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 568817000293 substrate binding site [chemical binding]; other site 568817000294 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 568817000295 active site 568817000296 catalytic residues [active] 568817000297 metal binding site [ion binding]; metal-binding site 568817000298 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 568817000299 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 568817000300 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 568817000301 poxB regulator PoxA; Provisional; Region: PRK09350 568817000302 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 568817000303 motif 1; other site 568817000304 dimer interface [polypeptide binding]; other site 568817000305 active site 568817000306 motif 2; other site 568817000307 motif 3; other site 568817000308 putative mechanosensitive channel protein; Provisional; Region: PRK10929 568817000309 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 568817000310 Mechanosensitive ion channel; Region: MS_channel; pfam00924 568817000311 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 568817000312 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 568817000313 catalytic site [active] 568817000314 putative active site [active] 568817000315 putative substrate binding site [chemical binding]; other site 568817000316 dimer interface [polypeptide binding]; other site 568817000317 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 568817000318 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 568817000319 AMIN domain; Region: AMIN; pfam11741 568817000320 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 568817000321 active site 568817000322 metal binding site [ion binding]; metal-binding site 568817000323 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 568817000324 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 568817000325 bacterial Hfq-like; Region: Hfq; cd01716 568817000326 hexamer interface [polypeptide binding]; other site 568817000327 Sm1 motif; other site 568817000328 RNA binding site [nucleotide binding]; other site 568817000329 Sm2 motif; other site 568817000330 FtsH protease regulator HflK; Provisional; Region: PRK10930 568817000331 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 568817000332 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 568817000333 FtsH protease regulator HflC; Provisional; Region: PRK11029 568817000334 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 568817000335 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 568817000336 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 568817000337 GDP-binding site [chemical binding]; other site 568817000338 ACT binding site; other site 568817000339 IMP binding site; other site 568817000340 exoribonuclease R; Provisional; Region: PRK11642 568817000341 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 568817000342 RNB domain; Region: RNB; pfam00773 568817000343 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 568817000344 RNA binding site [nucleotide binding]; other site 568817000345 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 568817000346 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 568817000347 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 568817000348 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 568817000349 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 568817000350 dimer interface [polypeptide binding]; other site 568817000351 ssDNA binding site [nucleotide binding]; other site 568817000352 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568817000353 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 568817000354 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 568817000355 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 568817000356 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 568817000357 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 568817000358 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 568817000359 active site 568817000360 elongation factor P; Validated; Region: PRK00529 568817000361 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 568817000362 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 568817000363 RNA binding site [nucleotide binding]; other site 568817000364 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 568817000365 RNA binding site [nucleotide binding]; other site 568817000366 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 568817000367 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568817000368 FeS/SAM binding site; other site 568817000369 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 568817000370 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 568817000371 ring oligomerisation interface [polypeptide binding]; other site 568817000372 ATP/Mg binding site [chemical binding]; other site 568817000373 stacking interactions; other site 568817000374 hinge regions; other site 568817000375 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 568817000376 oligomerisation interface [polypeptide binding]; other site 568817000377 mobile loop; other site 568817000378 roof hairpin; other site 568817000379 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568817000380 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 568817000381 putative ADP-binding pocket [chemical binding]; other site 568817000382 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 568817000383 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568817000384 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 568817000385 putative active site [active] 568817000386 putative catalytic site [active] 568817000387 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568817000388 EamA-like transporter family; Region: EamA; pfam00892 568817000389 transaldolase-like protein; Provisional; Region: PTZ00411 568817000390 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 568817000391 active site 568817000392 dimer interface [polypeptide binding]; other site 568817000393 catalytic residue [active] 568817000394 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 568817000395 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 568817000396 nucleotide binding site [chemical binding]; other site 568817000397 chaperone protein DnaJ; Provisional; Region: PRK10767 568817000398 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 568817000399 HSP70 interaction site [polypeptide binding]; other site 568817000400 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 568817000401 substrate binding site [polypeptide binding]; other site 568817000402 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 568817000403 Zn binding sites [ion binding]; other site 568817000404 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 568817000405 dimer interface [polypeptide binding]; other site 568817000406 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 568817000407 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 568817000408 active site 568817000409 Riboflavin kinase; Region: Flavokinase; smart00904 568817000410 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 568817000411 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568817000412 active site 568817000413 HIGH motif; other site 568817000414 nucleotide binding site [chemical binding]; other site 568817000415 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 568817000416 active site 568817000417 KMSKS motif; other site 568817000418 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 568817000419 tRNA binding surface [nucleotide binding]; other site 568817000420 anticodon binding site; other site 568817000421 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 568817000422 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 568817000423 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 568817000424 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 568817000425 dihydrodipicolinate reductase; Provisional; Region: PRK00048 568817000426 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 568817000427 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 568817000428 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 568817000429 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 568817000430 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 568817000431 catalytic site [active] 568817000432 subunit interface [polypeptide binding]; other site 568817000433 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 568817000434 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568817000435 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 568817000436 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 568817000437 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568817000438 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568817000439 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 568817000440 IMP binding site; other site 568817000441 dimer interface [polypeptide binding]; other site 568817000442 interdomain contacts; other site 568817000443 partial ornithine binding site; other site 568817000444 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 568817000445 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 568817000446 folate binding site [chemical binding]; other site 568817000447 NADP+ binding site [chemical binding]; other site 568817000448 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 568817000449 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 568817000450 active site 568817000451 metal binding site [ion binding]; metal-binding site 568817000452 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 568817000453 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 568817000454 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 568817000455 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 568817000456 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 568817000457 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 568817000458 SurA N-terminal domain; Region: SurA_N; pfam09312 568817000459 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 568817000460 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 568817000461 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 568817000462 OstA-like protein; Region: OstA; pfam03968 568817000463 Organic solvent tolerance protein; Region: OstA_C; pfam04453 568817000464 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 568817000465 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 568817000466 putative metal binding site [ion binding]; other site 568817000467 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 568817000468 HSP70 interaction site [polypeptide binding]; other site 568817000469 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 568817000470 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568817000471 Walker A/P-loop; other site 568817000472 ATP binding site [chemical binding]; other site 568817000473 Q-loop/lid; other site 568817000474 ABC transporter signature motif; other site 568817000475 Walker B; other site 568817000476 D-loop; other site 568817000477 H-loop/switch region; other site 568817000478 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 568817000479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568817000480 dimer interface [polypeptide binding]; other site 568817000481 conserved gate region; other site 568817000482 putative PBP binding loops; other site 568817000483 ABC-ATPase subunit interface; other site 568817000484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568817000485 dimer interface [polypeptide binding]; other site 568817000486 conserved gate region; other site 568817000487 putative PBP binding loops; other site 568817000488 ABC-ATPase subunit interface; other site 568817000489 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 568817000490 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 568817000491 MraW methylase family; Region: Methyltransf_5; pfam01795 568817000492 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 568817000493 cell division protein FtsL; Provisional; Region: PRK10772 568817000494 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 568817000495 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 568817000496 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 568817000497 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 568817000498 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568817000499 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568817000500 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568817000501 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 568817000502 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568817000503 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568817000504 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568817000505 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 568817000506 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 568817000507 Mg++ binding site [ion binding]; other site 568817000508 putative catalytic motif [active] 568817000509 putative substrate binding site [chemical binding]; other site 568817000510 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 568817000511 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 568817000512 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568817000513 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568817000514 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 568817000515 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 568817000516 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 568817000517 active site 568817000518 homodimer interface [polypeptide binding]; other site 568817000519 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 568817000520 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568817000521 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568817000522 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568817000523 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 568817000524 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 568817000525 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 568817000526 cell division protein FtsQ; Provisional; Region: PRK10775 568817000527 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 568817000528 Cell division protein FtsQ; Region: FtsQ; pfam03799 568817000529 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 568817000530 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568817000531 Cell division protein FtsA; Region: FtsA; pfam14450 568817000532 cell division protein FtsZ; Validated; Region: PRK09330 568817000533 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 568817000534 nucleotide binding site [chemical binding]; other site 568817000535 SulA interaction site; other site 568817000536 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 568817000537 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 568817000538 Protein of unknown function (DUF721); Region: DUF721; cl02324 568817000539 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 568817000540 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 568817000541 SEC-C motif; Region: SEC-C; pfam02810 568817000542 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 568817000543 dephospho-CoA kinase; Region: TIGR00152 568817000544 CoA-binding site [chemical binding]; other site 568817000545 ATP-binding [chemical binding]; other site 568817000546 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 568817000547 serine endoprotease; Provisional; Region: PRK10942 568817000548 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 568817000549 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568817000550 protein binding site [polypeptide binding]; other site 568817000551 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568817000552 protein binding site [polypeptide binding]; other site 568817000553 CTP synthetase; Validated; Region: pyrG; PRK05380 568817000554 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 568817000555 Catalytic site [active] 568817000556 active site 568817000557 UTP binding site [chemical binding]; other site 568817000558 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 568817000559 active site 568817000560 putative oxyanion hole; other site 568817000561 catalytic triad [active] 568817000562 enolase; Provisional; Region: eno; PRK00077 568817000563 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 568817000564 dimer interface [polypeptide binding]; other site 568817000565 metal binding site [ion binding]; metal-binding site 568817000566 substrate binding pocket [chemical binding]; other site 568817000567 Fimbrial protein; Region: Fimbrial; pfam00419 568817000568 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 568817000569 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 568817000570 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 568817000571 active site 568817000572 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 568817000573 Flavodoxin; Region: Flavodoxin_1; pfam00258 568817000574 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 568817000575 FAD binding pocket [chemical binding]; other site 568817000576 FAD binding motif [chemical binding]; other site 568817000577 catalytic residues [active] 568817000578 NAD binding pocket [chemical binding]; other site 568817000579 phosphate binding motif [ion binding]; other site 568817000580 beta-alpha-beta structure motif; other site 568817000581 sulfite reductase subunit beta; Provisional; Region: PRK13504 568817000582 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 568817000583 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 568817000584 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 568817000585 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 568817000586 Active Sites [active] 568817000587 siroheme synthase; Provisional; Region: cysG; PRK10637 568817000588 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 568817000589 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 568817000590 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 568817000591 active site 568817000592 SAM binding site [chemical binding]; other site 568817000593 homodimer interface [polypeptide binding]; other site 568817000594 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 568817000595 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 568817000596 Active Sites [active] 568817000597 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 568817000598 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 568817000599 CysD dimerization site [polypeptide binding]; other site 568817000600 G1 box; other site 568817000601 putative GEF interaction site [polypeptide binding]; other site 568817000602 GTP/Mg2+ binding site [chemical binding]; other site 568817000603 Switch I region; other site 568817000604 G2 box; other site 568817000605 G3 box; other site 568817000606 Switch II region; other site 568817000607 G4 box; other site 568817000608 G5 box; other site 568817000609 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 568817000610 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 568817000611 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 568817000612 ligand-binding site [chemical binding]; other site 568817000613 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 568817000614 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 568817000615 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 568817000616 substrate binding site; other site 568817000617 dimer interface; other site 568817000618 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 568817000619 homotrimer interaction site [polypeptide binding]; other site 568817000620 zinc binding site [ion binding]; other site 568817000621 CDP-binding sites; other site 568817000622 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 568817000623 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568817000624 Peptidase family M23; Region: Peptidase_M23; pfam01551 568817000625 hypothetical protein; Validated; Region: PRK03661 568817000626 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 568817000627 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 568817000628 motif 1; other site 568817000629 active site 568817000630 motif 2; other site 568817000631 motif 3; other site 568817000632 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 568817000633 DHHA1 domain; Region: DHHA1; pfam02272 568817000634 carbon storage regulator; Provisional; Region: PRK01712 568817000635 glutamate--cysteine ligase; Provisional; Region: PRK02107 568817000636 signal recognition particle protein; Provisional; Region: PRK10867 568817000637 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 568817000638 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 568817000639 P loop; other site 568817000640 GTP binding site [chemical binding]; other site 568817000641 Signal peptide binding domain; Region: SRP_SPB; pfam02978 568817000642 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 568817000643 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 568817000644 RimM N-terminal domain; Region: RimM; pfam01782 568817000645 PRC-barrel domain; Region: PRC; pfam05239 568817000646 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 568817000647 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 568817000648 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 568817000649 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 568817000650 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 568817000651 active site 568817000652 protein disaggregation chaperone; Provisional; Region: PRK10865 568817000653 Clp amino terminal domain; Region: Clp_N; pfam02861 568817000654 Clp amino terminal domain; Region: Clp_N; pfam02861 568817000655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568817000656 Walker A motif; other site 568817000657 ATP binding site [chemical binding]; other site 568817000658 Walker B motif; other site 568817000659 arginine finger; other site 568817000660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568817000661 Walker A motif; other site 568817000662 ATP binding site [chemical binding]; other site 568817000663 Walker B motif; other site 568817000664 arginine finger; other site 568817000665 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 568817000666 transketolase; Reviewed; Region: PRK12753 568817000667 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 568817000668 TPP-binding site [chemical binding]; other site 568817000669 dimer interface [polypeptide binding]; other site 568817000670 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 568817000671 PYR/PP interface [polypeptide binding]; other site 568817000672 dimer interface [polypeptide binding]; other site 568817000673 TPP binding site [chemical binding]; other site 568817000674 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568817000675 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 568817000676 Phosphoglycerate kinase; Region: PGK; pfam00162 568817000677 substrate binding site [chemical binding]; other site 568817000678 hinge regions; other site 568817000679 ADP binding site [chemical binding]; other site 568817000680 catalytic site [active] 568817000681 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 568817000682 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 568817000683 active site 568817000684 intersubunit interface [polypeptide binding]; other site 568817000685 zinc binding site [ion binding]; other site 568817000686 Na+ binding site [ion binding]; other site 568817000687 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 568817000688 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568817000689 active site 568817000690 dimer interface [polypeptide binding]; other site 568817000691 proline aminopeptidase P II; Provisional; Region: PRK10879 568817000692 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 568817000693 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 568817000694 active site 568817000695 putative global regulator; Reviewed; Region: PRK09559 568817000696 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 568817000697 peptide chain release factor 2; Provisional; Region: PRK08787 568817000698 This domain is found in peptide chain release factors; Region: PCRF; smart00937 568817000699 RF-1 domain; Region: RF-1; pfam00472 568817000700 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 568817000701 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 568817000702 dimer interface [polypeptide binding]; other site 568817000703 putative anticodon binding site; other site 568817000704 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 568817000705 motif 1; other site 568817000706 active site 568817000707 motif 2; other site 568817000708 motif 3; other site 568817000709 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 568817000710 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 568817000711 putative active site [active] 568817000712 Ap4A binding site [chemical binding]; other site 568817000713 nudix motif; other site 568817000714 putative metal binding site [ion binding]; other site 568817000715 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 568817000716 thymidylate synthase; Reviewed; Region: thyA; PRK01827 568817000717 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 568817000718 dimerization interface [polypeptide binding]; other site 568817000719 active site 568817000720 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 568817000721 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 568817000722 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 568817000723 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 568817000724 AAA domain; Region: AAA_30; pfam13604 568817000725 Family description; Region: UvrD_C_2; pfam13538 568817000726 murein transglycosylase A; Provisional; Region: mltA; PRK11162 568817000727 MltA specific insert domain; Region: MltA; smart00925 568817000728 3D domain; Region: 3D; pfam06725 568817000729 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 568817000730 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 568817000731 trimer interface [polypeptide binding]; other site 568817000732 active site 568817000733 substrate binding site [chemical binding]; other site 568817000734 CoA binding site [chemical binding]; other site 568817000735 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 568817000736 active site 568817000737 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 568817000738 rRNA interaction site [nucleotide binding]; other site 568817000739 S8 interaction site; other site 568817000740 putative laminin-1 binding site; other site 568817000741 elongation factor Ts; Provisional; Region: tsf; PRK09377 568817000742 Elongation factor TS; Region: EF_TS; pfam00889 568817000743 Elongation factor TS; Region: EF_TS; pfam00889 568817000744 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 568817000745 putative nucleotide binding site [chemical binding]; other site 568817000746 uridine monophosphate binding site [chemical binding]; other site 568817000747 homohexameric interface [polypeptide binding]; other site 568817000748 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 568817000749 hinge region; other site 568817000750 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 568817000751 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 568817000752 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 568817000753 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 568817000754 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 568817000755 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 568817000756 catalytic residue [active] 568817000757 putative FPP diphosphate binding site; other site 568817000758 putative FPP binding hydrophobic cleft; other site 568817000759 dimer interface [polypeptide binding]; other site 568817000760 putative IPP diphosphate binding site; other site 568817000761 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 568817000762 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 568817000763 zinc metallopeptidase RseP; Provisional; Region: PRK10779 568817000764 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 568817000765 active site 568817000766 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 568817000767 protein binding site [polypeptide binding]; other site 568817000768 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 568817000769 protein binding site [polypeptide binding]; other site 568817000770 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 568817000771 putative substrate binding region [chemical binding]; other site 568817000772 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 568817000773 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568817000774 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568817000775 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568817000776 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568817000777 Surface antigen; Region: Bac_surface_Ag; pfam01103 568817000778 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 568817000779 periplasmic chaperone; Provisional; Region: PRK10780 568817000780 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 568817000781 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 568817000782 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 568817000783 trimer interface [polypeptide binding]; other site 568817000784 active site 568817000785 UDP-GlcNAc binding site [chemical binding]; other site 568817000786 lipid binding site [chemical binding]; lipid-binding site 568817000787 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 568817000788 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 568817000789 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 568817000790 active site 568817000791 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 568817000792 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 568817000793 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 568817000794 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 568817000795 putative active site [active] 568817000796 putative PHP Thumb interface [polypeptide binding]; other site 568817000797 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 568817000798 generic binding surface II; other site 568817000799 generic binding surface I; other site 568817000800 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 568817000801 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 568817000802 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 568817000803 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 568817000804 Ligand Binding Site [chemical binding]; other site 568817000805 TilS substrate binding domain; Region: TilS; pfam09179 568817000806 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 568817000807 prolyl-tRNA synthetase; Provisional; Region: PRK09194 568817000808 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 568817000809 dimer interface [polypeptide binding]; other site 568817000810 motif 1; other site 568817000811 active site 568817000812 motif 2; other site 568817000813 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 568817000814 putative deacylase active site [active] 568817000815 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 568817000816 active site 568817000817 motif 3; other site 568817000818 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 568817000819 anticodon binding site; other site 568817000820 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 568817000821 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568817000822 active site 568817000823 motif I; other site 568817000824 motif II; other site 568817000825 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 568817000826 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 568817000827 domain interface [polypeptide binding]; other site 568817000828 putative active site [active] 568817000829 catalytic site [active] 568817000830 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 568817000831 putative active site [active] 568817000832 catalytic site [active] 568817000833 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568817000834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568817000835 putative substrate translocation pore; other site 568817000836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568817000837 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 568817000838 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568817000839 HlyD family secretion protein; Region: HlyD_3; pfam13437 568817000840 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 568817000841 dimer interface [polypeptide binding]; other site 568817000842 active site 568817000843 lipoyl synthase; Provisional; Region: PRK05481 568817000844 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568817000845 FeS/SAM binding site; other site 568817000846 lipoate-protein ligase B; Provisional; Region: PRK14342 568817000847 hypothetical protein; Provisional; Region: PRK04998 568817000848 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 568817000849 hypothetical protein; Provisional; Region: PRK05421 568817000850 putative catalytic site [active] 568817000851 putative metal binding site [ion binding]; other site 568817000852 putative phosphate binding site [ion binding]; other site 568817000853 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 568817000854 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568817000855 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568817000856 catalytic residue [active] 568817000857 Methyltransferase domain; Region: Methyltransf_11; pfam08241 568817000858 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 568817000859 RNA/DNA hybrid binding site [nucleotide binding]; other site 568817000860 active site 568817000861 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 568817000862 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 568817000863 active site 568817000864 catalytic site [active] 568817000865 substrate binding site [chemical binding]; other site 568817000866 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 568817000867 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 568817000868 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 568817000869 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 568817000870 SmpB-tmRNA interface; other site 568817000871 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 568817000872 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 568817000873 heat shock protein GrpE; Provisional; Region: PRK14140 568817000874 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 568817000875 dimer interface [polypeptide binding]; other site 568817000876 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 568817000877 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 568817000878 ligand binding site [chemical binding]; other site 568817000879 active site 568817000880 UGI interface [polypeptide binding]; other site 568817000881 catalytic site [active] 568817000882 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 568817000883 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 568817000884 ATP binding site [chemical binding]; other site 568817000885 Mg++ binding site [ion binding]; other site 568817000886 motif III; other site 568817000887 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568817000888 nucleotide binding region [chemical binding]; other site 568817000889 ATP-binding site [chemical binding]; other site 568817000890 GTP-binding protein LepA; Provisional; Region: PRK05433 568817000891 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 568817000892 G1 box; other site 568817000893 putative GEF interaction site [polypeptide binding]; other site 568817000894 GTP/Mg2+ binding site [chemical binding]; other site 568817000895 Switch I region; other site 568817000896 G2 box; other site 568817000897 G3 box; other site 568817000898 Switch II region; other site 568817000899 G4 box; other site 568817000900 G5 box; other site 568817000901 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 568817000902 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 568817000903 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 568817000904 signal peptidase I; Provisional; Region: PRK10861 568817000905 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 568817000906 Catalytic site [active] 568817000907 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 568817000908 ribonuclease III; Reviewed; Region: rnc; PRK00102 568817000909 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 568817000910 dimerization interface [polypeptide binding]; other site 568817000911 active site 568817000912 metal binding site [ion binding]; metal-binding site 568817000913 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 568817000914 dsRNA binding site [nucleotide binding]; other site 568817000915 GTPase Era; Reviewed; Region: era; PRK00089 568817000916 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 568817000917 G1 box; other site 568817000918 GTP/Mg2+ binding site [chemical binding]; other site 568817000919 Switch I region; other site 568817000920 G2 box; other site 568817000921 Switch II region; other site 568817000922 G3 box; other site 568817000923 G4 box; other site 568817000924 G5 box; other site 568817000925 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 568817000926 active site 568817000927 hydrophilic channel; other site 568817000928 dimerization interface [polypeptide binding]; other site 568817000929 catalytic residues [active] 568817000930 active site lid [active] 568817000931 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 568817000932 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 568817000933 CoA binding domain; Region: CoA_binding; smart00881 568817000934 CoA-ligase; Region: Ligase_CoA; pfam00549 568817000935 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 568817000936 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 568817000937 CoA-ligase; Region: Ligase_CoA; pfam00549 568817000938 phosphoglucomutase; Validated; Region: PRK07564 568817000939 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 568817000940 active site 568817000941 substrate binding site [chemical binding]; other site 568817000942 metal binding site [ion binding]; metal-binding site 568817000943 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 568817000944 penicillin-binding protein 2; Provisional; Region: PRK10795 568817000945 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 568817000946 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 568817000947 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 568817000948 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 568817000949 active site 568817000950 (T/H)XGH motif; other site 568817000951 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 568817000952 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 568817000953 Lipopolysaccharide-assembly; Region: LptE; cl01125 568817000954 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 568817000955 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 568817000956 HIGH motif; other site 568817000957 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 568817000958 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568817000959 active site 568817000960 KMSKS motif; other site 568817000961 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 568817000962 tRNA binding surface [nucleotide binding]; other site 568817000963 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 568817000964 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 568817000965 putative active site [active] 568817000966 catalytic triad [active] 568817000967 putative dimer interface [polypeptide binding]; other site 568817000968 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 568817000969 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 568817000970 Transporter associated domain; Region: CorC_HlyC; smart01091 568817000971 metal-binding heat shock protein; Provisional; Region: PRK00016 568817000972 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568817000973 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 568817000974 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 568817000975 active site turn [active] 568817000976 phosphorylation site [posttranslational modification] 568817000977 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 568817000978 HPr interaction site; other site 568817000979 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568817000980 active site 568817000981 phosphorylation site [posttranslational modification] 568817000982 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 568817000983 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568817000984 active site 568817000985 HIGH motif; other site 568817000986 nucleotide binding site [chemical binding]; other site 568817000987 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 568817000988 KMSKS motif; other site 568817000989 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 568817000990 ferric uptake regulator; Provisional; Region: fur; PRK09462 568817000991 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 568817000992 metal binding site 2 [ion binding]; metal-binding site 568817000993 putative DNA binding helix; other site 568817000994 metal binding site 1 [ion binding]; metal-binding site 568817000995 dimer interface [polypeptide binding]; other site 568817000996 structural Zn2+ binding site [ion binding]; other site 568817000997 flavodoxin FldA; Validated; Region: PRK09267 568817000998 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568817000999 active site 568817001000 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568817001001 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568817001002 Walker A/P-loop; other site 568817001003 ATP binding site [chemical binding]; other site 568817001004 Q-loop/lid; other site 568817001005 ABC transporter signature motif; other site 568817001006 Walker B; other site 568817001007 D-loop; other site 568817001008 H-loop/switch region; other site 568817001009 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 568817001010 inner membrane transport permease; Provisional; Region: PRK15066 568817001011 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 568817001012 catalytic center binding site [active] 568817001013 ATP binding site [chemical binding]; other site 568817001014 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 568817001015 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 568817001016 active site 568817001017 NTP binding site [chemical binding]; other site 568817001018 metal binding triad [ion binding]; metal-binding site 568817001019 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 568817001020 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 568817001021 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 568817001022 S-adenosylmethionine synthetase; Validated; Region: PRK05250 568817001023 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 568817001024 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 568817001025 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 568817001026 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 568817001027 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 568817001028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568817001029 S-adenosylmethionine binding site [chemical binding]; other site 568817001030 DNA polymerase III subunit psi; Validated; Region: PRK06856 568817001031 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 568817001032 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 568817001033 G1 box; other site 568817001034 putative GEF interaction site [polypeptide binding]; other site 568817001035 GTP/Mg2+ binding site [chemical binding]; other site 568817001036 Switch I region; other site 568817001037 G2 box; other site 568817001038 G3 box; other site 568817001039 Switch II region; other site 568817001040 G4 box; other site 568817001041 G5 box; other site 568817001042 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 568817001043 phosphopentomutase; Provisional; Region: PRK05362 568817001044 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 568817001045 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 568817001046 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 568817001047 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 568817001048 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 568817001049 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 568817001050 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568817001051 active site 568817001052 nucleotide binding site [chemical binding]; other site 568817001053 HIGH motif; other site 568817001054 KMSKS motif; other site 568817001055 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 568817001056 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 568817001057 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 568817001058 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 568817001059 TolA protein; Region: tolA_full; TIGR02794 568817001060 TolA C-terminal; Region: TolA; pfam06519 568817001061 translocation protein TolB; Provisional; Region: tolB; PRK03629 568817001062 TolB amino-terminal domain; Region: TolB_N; pfam04052 568817001063 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 568817001064 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 568817001065 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 568817001066 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 568817001067 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 568817001068 ligand binding site [chemical binding]; other site 568817001069 tol-pal system protein YbgF; Provisional; Region: PRK10803 568817001070 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 568817001071 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568817001072 catalytic core [active] 568817001073 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568817001074 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 568817001075 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 568817001076 MgtE intracellular N domain; Region: MgtE_N; smart00924 568817001077 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 568817001078 Divalent cation transporter; Region: MgtE; cl00786 568817001079 exopolyphosphatase; Provisional; Region: PRK10854 568817001080 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 568817001081 polyphosphate kinase; Provisional; Region: PRK05443 568817001082 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 568817001083 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 568817001084 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 568817001085 putative active site [active] 568817001086 catalytic site [active] 568817001087 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 568817001088 domain interface [polypeptide binding]; other site 568817001089 active site 568817001090 catalytic site [active] 568817001091 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 568817001092 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 568817001093 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 568817001094 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 568817001095 active site 568817001096 substrate binding site [chemical binding]; other site 568817001097 cosubstrate binding site; other site 568817001098 catalytic site [active] 568817001099 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 568817001100 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 568817001101 dimerization interface [polypeptide binding]; other site 568817001102 putative ATP binding site [chemical binding]; other site 568817001103 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 568817001104 dihydrodipicolinate synthase; Region: dapA; TIGR00674 568817001105 dimer interface [polypeptide binding]; other site 568817001106 active site 568817001107 catalytic residue [active] 568817001108 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 568817001109 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 568817001110 putative dimer interface [polypeptide binding]; other site 568817001111 putative anticodon binding site; other site 568817001112 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 568817001113 homodimer interface [polypeptide binding]; other site 568817001114 motif 1; other site 568817001115 motif 2; other site 568817001116 active site 568817001117 motif 3; other site 568817001118 sulfate transport protein; Provisional; Region: cysT; CHL00187 568817001119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568817001120 dimer interface [polypeptide binding]; other site 568817001121 conserved gate region; other site 568817001122 putative PBP binding loops; other site 568817001123 ABC-ATPase subunit interface; other site 568817001124 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 568817001125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568817001126 dimer interface [polypeptide binding]; other site 568817001127 conserved gate region; other site 568817001128 putative PBP binding loops; other site 568817001129 ABC-ATPase subunit interface; other site 568817001130 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 568817001131 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 568817001132 Walker A/P-loop; other site 568817001133 ATP binding site [chemical binding]; other site 568817001134 Q-loop/lid; other site 568817001135 ABC transporter signature motif; other site 568817001136 Walker B; other site 568817001137 D-loop; other site 568817001138 H-loop/switch region; other site 568817001139 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 568817001140 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 568817001141 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 568817001142 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 568817001143 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 568817001144 dimerization domain swap beta strand [polypeptide binding]; other site 568817001145 regulatory protein interface [polypeptide binding]; other site 568817001146 active site 568817001147 regulatory phosphorylation site [posttranslational modification]; other site 568817001148 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 568817001149 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 568817001150 dimer interface [polypeptide binding]; other site 568817001151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568817001152 catalytic residue [active] 568817001153 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 568817001154 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 568817001155 nucleotide binding pocket [chemical binding]; other site 568817001156 K-X-D-G motif; other site 568817001157 catalytic site [active] 568817001158 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 568817001159 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 568817001160 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 568817001161 Dimer interface [polypeptide binding]; other site 568817001162 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 568817001163 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 568817001164 HIGH motif; other site 568817001165 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 568817001166 active site 568817001167 KMSKS motif; other site 568817001168 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 568817001169 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 568817001170 VacJ like lipoprotein; Region: VacJ; cl01073 568817001171 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 568817001172 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 568817001173 putative acyl-acceptor binding pocket; other site 568817001174 potassium/proton antiporter; Reviewed; Region: PRK05326 568817001175 proline/glycine betaine transporter; Provisional; Region: PRK10642 568817001176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568817001177 putative substrate translocation pore; other site 568817001178 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 568817001179 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 568817001180 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 568817001181 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 568817001182 homodimer interface [polypeptide binding]; other site 568817001183 NADP binding site [chemical binding]; other site 568817001184 substrate binding site [chemical binding]; other site 568817001185 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 568817001186 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 568817001187 active site 568817001188 HIGH motif; other site 568817001189 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 568817001190 KMSKS motif; other site 568817001191 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 568817001192 tRNA binding surface [nucleotide binding]; other site 568817001193 anticodon binding site; other site 568817001194 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 568817001195 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568817001196 putative active site [active] 568817001197 putative metal binding site [ion binding]; other site 568817001198 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 568817001199 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 568817001200 metal binding site [ion binding]; metal-binding site 568817001201 dimer interface [polypeptide binding]; other site 568817001202 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 568817001203 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 568817001204 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 568817001205 active site 568817001206 tetramer interface; other site 568817001207 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 568817001208 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 568817001209 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 568817001210 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 568817001211 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 568817001212 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 568817001213 putative NAD(P) binding site [chemical binding]; other site 568817001214 active site 568817001215 putative substrate binding site [chemical binding]; other site 568817001216 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 568817001217 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 568817001218 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 568817001219 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 568817001220 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 568817001221 putative active site [active] 568817001222 catalytic site [active] 568817001223 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 568817001224 putative active site [active] 568817001225 catalytic site [active] 568817001226 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 568817001227 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 568817001228 active site 568817001229 HIGH motif; other site 568817001230 dimer interface [polypeptide binding]; other site 568817001231 KMSKS motif; other site 568817001232 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568817001233 RNA binding surface [nucleotide binding]; other site 568817001234 pyridoxamine kinase; Validated; Region: PRK05756 568817001235 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 568817001236 dimer interface [polypeptide binding]; other site 568817001237 pyridoxal binding site [chemical binding]; other site 568817001238 ATP binding site [chemical binding]; other site 568817001239 endonuclease III; Provisional; Region: PRK10702 568817001240 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568817001241 minor groove reading motif; other site 568817001242 helix-hairpin-helix signature motif; other site 568817001243 substrate binding pocket [chemical binding]; other site 568817001244 active site 568817001245 electron transport complex RsxE subunit; Provisional; Region: PRK12405 568817001246 electron transport complex protein RnfG; Validated; Region: PRK01908 568817001247 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 568817001248 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 568817001249 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 568817001250 lipoyl-biotinyl attachment site [posttranslational modification]; other site 568817001251 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 568817001252 SLBB domain; Region: SLBB; pfam10531 568817001253 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 568817001254 electron transport complex protein RnfB; Provisional; Region: PRK05113 568817001255 Putative Fe-S cluster; Region: FeS; cl17515 568817001256 electron transport complex protein RsxA; Provisional; Region: PRK05151 568817001257 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 568817001258 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 568817001259 Methyltransferase domain; Region: Methyltransf_23; pfam13489 568817001260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568817001261 S-adenosylmethionine binding site [chemical binding]; other site 568817001262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568817001263 S-adenosylmethionine binding site [chemical binding]; other site 568817001264 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 568817001265 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 568817001266 dimer interface [polypeptide binding]; other site 568817001267 anticodon binding site; other site 568817001268 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 568817001269 homodimer interface [polypeptide binding]; other site 568817001270 motif 1; other site 568817001271 active site 568817001272 motif 2; other site 568817001273 GAD domain; Region: GAD; pfam02938 568817001274 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 568817001275 active site 568817001276 motif 3; other site 568817001277 hypothetical protein; Validated; Region: PRK00110 568817001278 putative peptidase; Provisional; Region: PRK11649 568817001279 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 568817001280 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 568817001281 Peptidase family M23; Region: Peptidase_M23; pfam01551 568817001282 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 568817001283 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 568817001284 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 568817001285 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 568817001286 Glycoprotease family; Region: Peptidase_M22; pfam00814 568817001287 septum formation inhibitor; Reviewed; Region: minC; PRK03511 568817001288 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 568817001289 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 568817001290 cell division inhibitor MinD; Provisional; Region: PRK10818 568817001291 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 568817001292 Switch I; other site 568817001293 Switch II; other site 568817001294 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 568817001295 exoribonuclease II; Provisional; Region: PRK05054 568817001296 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 568817001297 RNB domain; Region: RNB; pfam00773 568817001298 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568817001299 DNA-binding site [nucleotide binding]; DNA binding site 568817001300 RNA-binding motif; other site 568817001301 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 568817001302 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 568817001303 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 568817001304 ferrochelatase; Reviewed; Region: hemH; PRK00035 568817001305 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 568817001306 C-terminal domain interface [polypeptide binding]; other site 568817001307 active site 568817001308 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 568817001309 active site 568817001310 N-terminal domain interface [polypeptide binding]; other site 568817001311 adenylate kinase; Reviewed; Region: adk; PRK00279 568817001312 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 568817001313 AMP-binding site [chemical binding]; other site 568817001314 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 568817001315 heat shock protein 90; Provisional; Region: PRK05218 568817001316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568817001317 ATP binding site [chemical binding]; other site 568817001318 Mg2+ binding site [ion binding]; other site 568817001319 G-X-G motif; other site 568817001320 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 568817001321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568817001322 Walker A motif; other site 568817001323 ATP binding site [chemical binding]; other site 568817001324 Walker B motif; other site 568817001325 arginine finger; other site 568817001326 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 568817001327 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 568817001328 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 568817001329 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 568817001330 metal binding site [ion binding]; metal-binding site 568817001331 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 568817001332 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 568817001333 ABC-ATPase subunit interface; other site 568817001334 dimer interface [polypeptide binding]; other site 568817001335 putative PBP binding regions; other site 568817001336 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 568817001337 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 568817001338 gene expression modulator; Provisional; Region: PRK10945 568817001339 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 568817001340 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 568817001341 dimerization interface [polypeptide binding]; other site 568817001342 active site 568817001343 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 568817001344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568817001345 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 568817001346 substrate binding site [chemical binding]; other site 568817001347 putative dimerization interface [polypeptide binding]; other site 568817001348 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 568817001349 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 568817001350 active site 568817001351 interdomain interaction site; other site 568817001352 putative metal-binding site [ion binding]; other site 568817001353 nucleotide binding site [chemical binding]; other site 568817001354 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 568817001355 domain I; other site 568817001356 DNA binding groove [nucleotide binding] 568817001357 phosphate binding site [ion binding]; other site 568817001358 domain II; other site 568817001359 domain III; other site 568817001360 nucleotide binding site [chemical binding]; other site 568817001361 catalytic site [active] 568817001362 domain IV; other site 568817001363 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 568817001364 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 568817001365 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 568817001366 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 568817001367 putative inner membrane peptidase; Provisional; Region: PRK11778 568817001368 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 568817001369 tandem repeat interface [polypeptide binding]; other site 568817001370 oligomer interface [polypeptide binding]; other site 568817001371 active site residues [active] 568817001372 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 568817001373 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568817001374 RNA binding surface [nucleotide binding]; other site 568817001375 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 568817001376 probable active site [active] 568817001377 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 568817001378 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 568817001379 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 568817001380 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 568817001381 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 568817001382 active site 568817001383 ribulose/triose binding site [chemical binding]; other site 568817001384 phosphate binding site [ion binding]; other site 568817001385 substrate (anthranilate) binding pocket [chemical binding]; other site 568817001386 product (indole) binding pocket [chemical binding]; other site 568817001387 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 568817001388 active site 568817001389 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 568817001390 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 568817001391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568817001392 catalytic residue [active] 568817001393 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 568817001394 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 568817001395 substrate binding site [chemical binding]; other site 568817001396 active site 568817001397 catalytic residues [active] 568817001398 heterodimer interface [polypeptide binding]; other site 568817001399 hypothetical protein; Provisional; Region: PRK02868 568817001400 intracellular septation protein A; Reviewed; Region: PRK00259 568817001401 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 568817001402 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 568817001403 dimer interface [polypeptide binding]; other site 568817001404 catalytic site [active] 568817001405 putative active site [active] 568817001406 putative substrate binding site [chemical binding]; other site 568817001407 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 568817001408 putative GSH binding site [chemical binding]; other site 568817001409 catalytic residues [active] 568817001410 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 568817001411 Lumazine binding domain; Region: Lum_binding; pfam00677 568817001412 Lumazine binding domain; Region: Lum_binding; pfam00677 568817001413 multidrug efflux protein; Reviewed; Region: PRK01766 568817001414 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 568817001415 cation binding site [ion binding]; other site 568817001416 pyruvate kinase; Provisional; Region: PRK09206 568817001417 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 568817001418 domain interfaces; other site 568817001419 active site 568817001420 murein lipoprotein; Provisional; Region: PRK15396 568817001421 cysteine desufuration protein SufE; Provisional; Region: PRK09296 568817001422 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 568817001423 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 568817001424 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568817001425 catalytic residue [active] 568817001426 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 568817001427 FeS assembly protein SufD; Region: sufD; TIGR01981 568817001428 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 568817001429 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 568817001430 Walker A/P-loop; other site 568817001431 ATP binding site [chemical binding]; other site 568817001432 Q-loop/lid; other site 568817001433 ABC transporter signature motif; other site 568817001434 Walker B; other site 568817001435 D-loop; other site 568817001436 H-loop/switch region; other site 568817001437 putative ABC transporter; Region: ycf24; CHL00085 568817001438 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 568817001439 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 568817001440 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 568817001441 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 568817001442 IHF - DNA interface [nucleotide binding]; other site 568817001443 IHF dimer interface [polypeptide binding]; other site 568817001444 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 568817001445 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 568817001446 putative tRNA-binding site [nucleotide binding]; other site 568817001447 B3/4 domain; Region: B3_4; pfam03483 568817001448 tRNA synthetase B5 domain; Region: B5; smart00874 568817001449 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 568817001450 dimer interface [polypeptide binding]; other site 568817001451 motif 1; other site 568817001452 motif 3; other site 568817001453 motif 2; other site 568817001454 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 568817001455 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 568817001456 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 568817001457 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 568817001458 dimer interface [polypeptide binding]; other site 568817001459 motif 1; other site 568817001460 active site 568817001461 motif 2; other site 568817001462 motif 3; other site 568817001463 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 568817001464 23S rRNA binding site [nucleotide binding]; other site 568817001465 L21 binding site [polypeptide binding]; other site 568817001466 L13 binding site [polypeptide binding]; other site 568817001467 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 568817001468 translation initiation factor IF-3; Region: infC; TIGR00168 568817001469 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 568817001470 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 568817001471 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 568817001472 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 568817001473 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 568817001474 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 568817001475 active site 568817001476 dimer interface [polypeptide binding]; other site 568817001477 motif 1; other site 568817001478 motif 2; other site 568817001479 motif 3; other site 568817001480 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 568817001481 anticodon binding site; other site 568817001482 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 568817001483 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568817001484 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568817001485 catalytic residue [active] 568817001486 adenylosuccinate lyase; Provisional; Region: PRK09285 568817001487 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 568817001488 tetramer interface [polypeptide binding]; other site 568817001489 active site 568817001490 putative lysogenization regulator; Reviewed; Region: PRK00218 568817001491 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 568817001492 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 568817001493 Ligand Binding Site [chemical binding]; other site 568817001494 heat shock protein HtpX; Provisional; Region: PRK05457 568817001495 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 568817001496 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 568817001497 FtsX-like permease family; Region: FtsX; pfam02687 568817001498 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 568817001499 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568817001500 Walker A/P-loop; other site 568817001501 ATP binding site [chemical binding]; other site 568817001502 Q-loop/lid; other site 568817001503 ABC transporter signature motif; other site 568817001504 Walker B; other site 568817001505 D-loop; other site 568817001506 H-loop/switch region; other site 568817001507 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 568817001508 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 568817001509 FtsX-like permease family; Region: FtsX; pfam02687 568817001510 transcription-repair coupling factor; Provisional; Region: PRK10689 568817001511 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 568817001512 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568817001513 ATP binding site [chemical binding]; other site 568817001514 putative Mg++ binding site [ion binding]; other site 568817001515 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568817001516 nucleotide binding region [chemical binding]; other site 568817001517 ATP-binding site [chemical binding]; other site 568817001518 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 568817001519 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 568817001520 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 568817001521 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 568817001522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568817001523 peptide chain release factor 1; Validated; Region: prfA; PRK00591 568817001524 This domain is found in peptide chain release factors; Region: PCRF; smart00937 568817001525 RF-1 domain; Region: RF-1; pfam00472 568817001526 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 568817001527 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 568817001528 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 568817001529 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 568817001530 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 568817001531 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 568817001532 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568817001533 active site 568817001534 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 568817001535 putative active site [active] 568817001536 catalytic residue [active] 568817001537 GTP-binding protein YchF; Reviewed; Region: PRK09601 568817001538 YchF GTPase; Region: YchF; cd01900 568817001539 G1 box; other site 568817001540 GTP/Mg2+ binding site [chemical binding]; other site 568817001541 Switch I region; other site 568817001542 G2 box; other site 568817001543 Switch II region; other site 568817001544 G3 box; other site 568817001545 G4 box; other site 568817001546 G5 box; other site 568817001547 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 568817001548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568817001549 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568817001550 putative substrate translocation pore; other site 568817001551 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 568817001552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568817001553 putative substrate translocation pore; other site 568817001554 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 568817001555 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 568817001556 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 568817001557 active site residue [active] 568817001558 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 568817001559 active site 568817001560 substrate binding pocket [chemical binding]; other site 568817001561 dimer interface [polypeptide binding]; other site 568817001562 ribonuclease E; Reviewed; Region: rne; PRK10811 568817001563 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 568817001564 homodimer interface [polypeptide binding]; other site 568817001565 oligonucleotide binding site [chemical binding]; other site 568817001566 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 568817001567 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 568817001568 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568817001569 RNA binding surface [nucleotide binding]; other site 568817001570 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 568817001571 active site 568817001572 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 568817001573 putative phosphate acyltransferase; Provisional; Region: PRK05331 568817001574 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 568817001575 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 568817001576 dimer interface [polypeptide binding]; other site 568817001577 active site 568817001578 CoA binding pocket [chemical binding]; other site 568817001579 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 568817001580 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 568817001581 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 568817001582 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 568817001583 NAD(P) binding site [chemical binding]; other site 568817001584 homotetramer interface [polypeptide binding]; other site 568817001585 homodimer interface [polypeptide binding]; other site 568817001586 active site 568817001587 acyl carrier protein; Provisional; Region: acpP; PRK00982 568817001588 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 568817001589 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 568817001590 dimer interface [polypeptide binding]; other site 568817001591 active site 568817001592 YceG-like family; Region: YceG; pfam02618 568817001593 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 568817001594 dimerization interface [polypeptide binding]; other site 568817001595 thymidylate kinase; Validated; Region: tmk; PRK00698 568817001596 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 568817001597 TMP-binding site; other site 568817001598 ATP-binding site [chemical binding]; other site 568817001599 DNA polymerase III subunit delta'; Validated; Region: PRK07993 568817001600 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 568817001601 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 568817001602 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 568817001603 active site 568817001604 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 568817001605 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568817001606 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 568817001607 active site turn [active] 568817001608 phosphorylation site [posttranslational modification] 568817001609 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 568817001610 nucleotide binding site/active site [active] 568817001611 HIT family signature motif; other site 568817001612 catalytic residue [active] 568817001613 thiamine kinase; Region: ycfN_thiK; TIGR02721 568817001614 active site 568817001615 substrate binding site [chemical binding]; other site 568817001616 ATP binding site [chemical binding]; other site 568817001617 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 568817001618 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 568817001619 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568817001620 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 568817001621 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 568817001622 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 568817001623 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 568817001624 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 568817001625 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 568817001626 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 568817001627 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 568817001628 active site 568817001629 homodimer interface [polypeptide binding]; other site 568817001630 protease 4; Provisional; Region: PRK10949 568817001631 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 568817001632 tandem repeat interface [polypeptide binding]; other site 568817001633 oligomer interface [polypeptide binding]; other site 568817001634 active site residues [active] 568817001635 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 568817001636 tandem repeat interface [polypeptide binding]; other site 568817001637 oligomer interface [polypeptide binding]; other site 568817001638 active site residues [active] 568817001639 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 568817001640 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 568817001641 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 568817001642 active site 568817001643 HIGH motif; other site 568817001644 KMSK motif region; other site 568817001645 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 568817001646 tRNA binding surface [nucleotide binding]; other site 568817001647 anticodon binding site; other site 568817001648 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 568817001649 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 568817001650 lipoprotein; Provisional; Region: PRK10598 568817001651 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568817001652 DNA-binding site [nucleotide binding]; DNA binding site 568817001653 RNA-binding motif; other site 568817001654 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 568817001655 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 568817001656 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 568817001657 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 568817001658 GIY-YIG motif/motif A; other site 568817001659 active site 568817001660 catalytic site [active] 568817001661 putative DNA binding site [nucleotide binding]; other site 568817001662 metal binding site [ion binding]; metal-binding site 568817001663 UvrB/uvrC motif; Region: UVR; pfam02151 568817001664 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 568817001665 DNA gyrase subunit A; Validated; Region: PRK05560 568817001666 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 568817001667 CAP-like domain; other site 568817001668 active site 568817001669 primary dimer interface [polypeptide binding]; other site 568817001670 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568817001671 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568817001672 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568817001673 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568817001674 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568817001675 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568817001676 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 568817001677 ATP cone domain; Region: ATP-cone; pfam03477 568817001678 Class I ribonucleotide reductase; Region: RNR_I; cd01679 568817001679 active site 568817001680 dimer interface [polypeptide binding]; other site 568817001681 catalytic residues [active] 568817001682 effector binding site; other site 568817001683 R2 peptide binding site; other site 568817001684 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 568817001685 dimer interface [polypeptide binding]; other site 568817001686 putative radical transfer pathway; other site 568817001687 diiron center [ion binding]; other site 568817001688 tyrosyl radical; other site 568817001689 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568817001690 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 568817001691 catalytic loop [active] 568817001692 iron binding site [ion binding]; other site 568817001693 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 568817001694 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 568817001695 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 568817001696 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 568817001697 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 568817001698 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 568817001699 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 568817001700 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 568817001701 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 568817001702 Protein export membrane protein; Region: SecD_SecF; pfam02355 568817001703 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 568817001704 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 568817001705 catalytic motif [active] 568817001706 Zn binding site [ion binding]; other site 568817001707 RibD C-terminal domain; Region: RibD_C; cl17279 568817001708 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 568817001709 homopentamer interface [polypeptide binding]; other site 568817001710 active site 568817001711 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 568817001712 putative RNA binding site [nucleotide binding]; other site 568817001713 thiamine monophosphate kinase; Provisional; Region: PRK05731 568817001714 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 568817001715 ATP binding site [chemical binding]; other site 568817001716 dimerization interface [polypeptide binding]; other site 568817001717 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 568817001718 tetramer interfaces [polypeptide binding]; other site 568817001719 binuclear metal-binding site [ion binding]; other site 568817001720 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 568817001721 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 568817001722 TPP-binding site; other site 568817001723 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 568817001724 PYR/PP interface [polypeptide binding]; other site 568817001725 dimer interface [polypeptide binding]; other site 568817001726 TPP binding site [chemical binding]; other site 568817001727 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568817001728 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 568817001729 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 568817001730 substrate binding pocket [chemical binding]; other site 568817001731 chain length determination region; other site 568817001732 substrate-Mg2+ binding site; other site 568817001733 catalytic residues [active] 568817001734 aspartate-rich region 1; other site 568817001735 active site lid residues [active] 568817001736 aspartate-rich region 2; other site 568817001737 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 568817001738 UbiA prenyltransferase family; Region: UbiA; pfam01040 568817001739 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 568817001740 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 568817001741 Subunit I/III interface [polypeptide binding]; other site 568817001742 Subunit III/IV interface [polypeptide binding]; other site 568817001743 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 568817001744 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 568817001745 D-pathway; other site 568817001746 Putative ubiquinol binding site [chemical binding]; other site 568817001747 Low-spin heme (heme b) binding site [chemical binding]; other site 568817001748 Putative water exit pathway; other site 568817001749 Binuclear center (heme o3/CuB) [ion binding]; other site 568817001750 K-pathway; other site 568817001751 Putative proton exit pathway; other site 568817001752 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 568817001753 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 568817001754 BolA-like protein; Region: BolA; cl00386 568817001755 trigger factor; Provisional; Region: tig; PRK01490 568817001756 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 568817001757 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 568817001758 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 568817001759 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 568817001760 oligomer interface [polypeptide binding]; other site 568817001761 active site residues [active] 568817001762 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 568817001763 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 568817001764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568817001765 Walker A motif; other site 568817001766 ATP binding site [chemical binding]; other site 568817001767 Walker B motif; other site 568817001768 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 568817001769 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 568817001770 Found in ATP-dependent protease La (LON); Region: LON; smart00464 568817001771 Found in ATP-dependent protease La (LON); Region: LON; smart00464 568817001772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568817001773 Walker A motif; other site 568817001774 ATP binding site [chemical binding]; other site 568817001775 Walker B motif; other site 568817001776 arginine finger; other site 568817001777 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 568817001778 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 568817001779 IHF dimer interface [polypeptide binding]; other site 568817001780 IHF - DNA interface [nucleotide binding]; other site 568817001781 periplasmic folding chaperone; Provisional; Region: PRK10788 568817001782 SurA N-terminal domain; Region: SurA_N_3; cl07813 568817001783 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 568817001784 exonuclease I; Provisional; Region: sbcB; PRK11779 568817001785 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 568817001786 active site 568817001787 catalytic site [active] 568817001788 substrate binding site [chemical binding]; other site 568817001789 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 568817001790 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 568817001791 ApbE family; Region: ApbE; pfam02424 568817001792 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 568817001793 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 568817001794 ligand binding site [chemical binding]; other site 568817001795 NAD binding site [chemical binding]; other site 568817001796 catalytic site [active] 568817001797 homodimer interface [polypeptide binding]; other site 568817001798 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 568817001799 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 568817001800 dimerization interface 3.5A [polypeptide binding]; other site 568817001801 active site 568817001802 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 568817001803 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 568817001804 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 568817001805 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568817001806 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568817001807 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 568817001808 Colicin V production protein; Region: Colicin_V; cl00567 568817001809 amidophosphoribosyltransferase; Provisional; Region: PRK09246 568817001810 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 568817001811 active site 568817001812 tetramer interface [polypeptide binding]; other site 568817001813 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568817001814 active site 568817001815 propionate/acetate kinase; Provisional; Region: PRK12379 568817001816 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 568817001817 phosphate acetyltransferase; Reviewed; Region: PRK05632 568817001818 DRTGG domain; Region: DRTGG; pfam07085 568817001819 phosphate acetyltransferase; Region: pta; TIGR00651 568817001820 outer membrane protein A; Reviewed; Region: PRK10808 568817001821 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 568817001822 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 568817001823 ligand binding site [chemical binding]; other site 568817001824 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 568817001825 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 568817001826 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 568817001827 active site 2 [active] 568817001828 dimer interface [polypeptide binding]; other site 568817001829 active site 1 [active] 568817001830 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 568817001831 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 568817001832 quinone interaction residues [chemical binding]; other site 568817001833 active site 568817001834 catalytic residues [active] 568817001835 FMN binding site [chemical binding]; other site 568817001836 substrate binding site [chemical binding]; other site 568817001837 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 568817001838 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 568817001839 trimer interface [polypeptide binding]; other site 568817001840 eyelet of channel; other site 568817001841 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 568817001842 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 568817001843 Ligand binding site; other site 568817001844 oligomer interface; other site 568817001845 Trm112p-like protein; Region: Trm112p; cl01066 568817001846 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 568817001847 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 568817001848 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 568817001849 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568817001850 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568817001851 Walker A/P-loop; other site 568817001852 ATP binding site [chemical binding]; other site 568817001853 Q-loop/lid; other site 568817001854 ABC transporter signature motif; other site 568817001855 Walker B; other site 568817001856 D-loop; other site 568817001857 H-loop/switch region; other site 568817001858 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 568817001859 IHF dimer interface [polypeptide binding]; other site 568817001860 IHF - DNA interface [nucleotide binding]; other site 568817001861 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 568817001862 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 568817001863 RNA binding site [nucleotide binding]; other site 568817001864 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 568817001865 RNA binding site [nucleotide binding]; other site 568817001866 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 568817001867 RNA binding site [nucleotide binding]; other site 568817001868 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 568817001869 RNA binding site [nucleotide binding]; other site 568817001870 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 568817001871 RNA binding site [nucleotide binding]; other site 568817001872 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 568817001873 RNA binding site [nucleotide binding]; other site 568817001874 cytidylate kinase; Provisional; Region: cmk; PRK00023 568817001875 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 568817001876 CMP-binding site; other site 568817001877 The sites determining sugar specificity; other site 568817001878 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 568817001879 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 568817001880 hinge; other site 568817001881 active site 568817001882 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 568817001883 homodimer interface [polypeptide binding]; other site 568817001884 substrate-cofactor binding pocket; other site 568817001885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568817001886 catalytic residue [active] 568817001887 seryl-tRNA synthetase; Provisional; Region: PRK05431 568817001888 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 568817001889 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 568817001890 dimer interface [polypeptide binding]; other site 568817001891 active site 568817001892 motif 1; other site 568817001893 motif 2; other site 568817001894 motif 3; other site 568817001895 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 568817001896 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 568817001897 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 568817001898 thioredoxin reductase; Provisional; Region: PRK10262 568817001899 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568817001900 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568817001901 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 568817001902 rRNA binding site [nucleotide binding]; other site 568817001903 predicted 30S ribosome binding site; other site 568817001904 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 568817001905 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 568817001906 active site 568817001907 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 568817001908 serine transporter; Region: stp; TIGR00814 568817001909 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568817001910 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 568817001911 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 568817001912 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 568817001913 FOG: CBS domain [General function prediction only]; Region: COG0517 568817001914 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 568817001915 Transporter associated domain; Region: CorC_HlyC; smart01091 568817001916 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 568817001917 trimer interface [polypeptide binding]; other site 568817001918 active site 568817001919 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 568817001920 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 568817001921 active site 568817001922 HIGH motif; other site 568817001923 KMSKS motif; other site 568817001924 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 568817001925 tRNA binding surface [nucleotide binding]; other site 568817001926 anticodon binding site; other site 568817001927 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 568817001928 homodecamer interface [polypeptide binding]; other site 568817001929 active site 568817001930 putative catalytic site residues [active] 568817001931 zinc binding site [ion binding]; other site 568817001932 GTP-CH-I/GFRP interaction surface; other site 568817001933 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 568817001934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568817001935 Walker A/P-loop; other site 568817001936 ATP binding site [chemical binding]; other site 568817001937 Q-loop/lid; other site 568817001938 ABC transporter signature motif; other site 568817001939 Walker B; other site 568817001940 D-loop; other site 568817001941 H-loop/switch region; other site 568817001942 ABC transporter; Region: ABC_tran_2; pfam12848 568817001943 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568817001944 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 568817001945 PapC N-terminal domain; Region: PapC_N; pfam13954 568817001946 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 568817001947 PapC C-terminal domain; Region: PapC_C; pfam13953 568817001948 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 568817001949 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 568817001950 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 568817001951 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 568817001952 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 568817001953 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568817001954 substrate binding pocket [chemical binding]; other site 568817001955 membrane-bound complex binding site; other site 568817001956 hinge residues; other site 568817001957 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568817001958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568817001959 dimer interface [polypeptide binding]; other site 568817001960 conserved gate region; other site 568817001961 putative PBP binding loops; other site 568817001962 ABC-ATPase subunit interface; other site 568817001963 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 568817001964 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568817001965 Walker A/P-loop; other site 568817001966 ATP binding site [chemical binding]; other site 568817001967 Q-loop/lid; other site 568817001968 ABC transporter signature motif; other site 568817001969 Walker B; other site 568817001970 D-loop; other site 568817001971 H-loop/switch region; other site 568817001972 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 568817001973 ATP binding site [chemical binding]; other site 568817001974 L-asparagine permease; Provisional; Region: PRK15049 568817001975 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 568817001976 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 568817001977 excinuclease ABC subunit B; Provisional; Region: PRK05298 568817001978 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568817001979 ATP binding site [chemical binding]; other site 568817001980 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568817001981 nucleotide binding region [chemical binding]; other site 568817001982 ATP-binding site [chemical binding]; other site 568817001983 Ultra-violet resistance protein B; Region: UvrB; pfam12344 568817001984 UvrB/uvrC motif; Region: UVR; pfam02151 568817001985 AAA domain; Region: AAA_26; pfam13500 568817001986 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 568817001987 biotin synthase; Provisional; Region: PRK15108 568817001988 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568817001989 FeS/SAM binding site; other site 568817001990 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 568817001991 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 568817001992 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568817001993 inhibitor-cofactor binding pocket; inhibition site 568817001994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568817001995 catalytic residue [active] 568817001996 GMP synthase; Reviewed; Region: guaA; PRK00074 568817001997 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 568817001998 AMP/PPi binding site [chemical binding]; other site 568817001999 candidate oxyanion hole; other site 568817002000 catalytic triad [active] 568817002001 potential glutamine specificity residues [chemical binding]; other site 568817002002 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 568817002003 ATP Binding subdomain [chemical binding]; other site 568817002004 Ligand Binding sites [chemical binding]; other site 568817002005 Dimerization subdomain; other site 568817002006 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 568817002007 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 568817002008 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 568817002009 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 568817002010 active site 568817002011 GTP-binding protein Der; Reviewed; Region: PRK00093 568817002012 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 568817002013 G1 box; other site 568817002014 GTP/Mg2+ binding site [chemical binding]; other site 568817002015 Switch I region; other site 568817002016 G2 box; other site 568817002017 Switch II region; other site 568817002018 G3 box; other site 568817002019 G4 box; other site 568817002020 G5 box; other site 568817002021 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 568817002022 G1 box; other site 568817002023 GTP/Mg2+ binding site [chemical binding]; other site 568817002024 Switch I region; other site 568817002025 G2 box; other site 568817002026 G3 box; other site 568817002027 Switch II region; other site 568817002028 G4 box; other site 568817002029 G5 box; other site 568817002030 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 568817002031 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 568817002032 Trp docking motif [polypeptide binding]; other site 568817002033 active site 568817002034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 568817002035 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 568817002036 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 568817002037 dimer interface [polypeptide binding]; other site 568817002038 motif 1; other site 568817002039 active site 568817002040 motif 2; other site 568817002041 motif 3; other site 568817002042 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 568817002043 anticodon binding site; other site 568817002044 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 568817002045 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 568817002046 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 568817002047 cytoskeletal protein RodZ; Provisional; Region: PRK10856 568817002048 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568817002049 non-specific DNA binding site [nucleotide binding]; other site 568817002050 salt bridge; other site 568817002051 sequence-specific DNA binding site [nucleotide binding]; other site 568817002052 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 568817002053 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568817002054 FeS/SAM binding site; other site 568817002055 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 568817002056 active site 568817002057 multimer interface [polypeptide binding]; other site 568817002058 cysteine desulfurase; Provisional; Region: PRK14012 568817002059 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 568817002060 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568817002061 catalytic residue [active] 568817002062 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 568817002063 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 568817002064 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 568817002065 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 568817002066 active site 568817002067 dimerization interface [polypeptide binding]; other site 568817002068 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 568817002069 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 568817002070 dimer interface [polypeptide binding]; other site 568817002071 active site 568817002072 glycine-pyridoxal phosphate binding site [chemical binding]; other site 568817002073 folate binding site [chemical binding]; other site 568817002074 NAD synthetase; Provisional; Region: PRK13981 568817002075 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 568817002076 multimer interface [polypeptide binding]; other site 568817002077 active site 568817002078 catalytic triad [active] 568817002079 protein interface 1 [polypeptide binding]; other site 568817002080 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 568817002081 homodimer interface [polypeptide binding]; other site 568817002082 NAD binding pocket [chemical binding]; other site 568817002083 ATP binding pocket [chemical binding]; other site 568817002084 Mg binding site [ion binding]; other site 568817002085 active-site loop [active] 568817002086 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 568817002087 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 568817002088 dimerization interface [polypeptide binding]; other site 568817002089 ATP binding site [chemical binding]; other site 568817002090 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 568817002091 dimerization interface [polypeptide binding]; other site 568817002092 ATP binding site [chemical binding]; other site 568817002093 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 568817002094 putative active site [active] 568817002095 catalytic triad [active] 568817002096 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 568817002097 nucleoside/Zn binding site; other site 568817002098 dimer interface [polypeptide binding]; other site 568817002099 catalytic motif [active] 568817002100 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 568817002101 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568817002102 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568817002103 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568817002104 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 568817002105 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 568817002106 E3 interaction surface; other site 568817002107 lipoyl attachment site [posttranslational modification]; other site 568817002108 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 568817002109 E3 interaction surface; other site 568817002110 lipoyl attachment site [posttranslational modification]; other site 568817002111 e3 binding domain; Region: E3_binding; pfam02817 568817002112 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 568817002113 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 568817002114 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 568817002115 dimer interface [polypeptide binding]; other site 568817002116 TPP-binding site [chemical binding]; other site 568817002117 oxidative damage protection protein; Provisional; Region: PRK05408 568817002118 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 568817002119 outer membrane lipoprotein; Provisional; Region: PRK11023 568817002120 BON domain; Region: BON; pfam04972 568817002121 BON domain; Region: BON; pfam04972 568817002122 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 568817002123 active site 568817002124 dimer interface [polypeptide binding]; other site 568817002125 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 568817002126 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 568817002127 putative ligand binding site [chemical binding]; other site 568817002128 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 568817002129 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 568817002130 putative SAM binding site [chemical binding]; other site 568817002131 putative homodimer interface [polypeptide binding]; other site 568817002132 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 568817002133 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 568817002134 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 568817002135 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 568817002136 23S rRNA interface [nucleotide binding]; other site 568817002137 L3 interface [polypeptide binding]; other site 568817002138 hypothetical protein; Provisional; Region: PRK11677 568817002139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 568817002140 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 568817002141 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 568817002142 putative acyl-acceptor binding pocket; other site 568817002143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 568817002144 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 568817002145 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 568817002146 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 568817002147 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 568817002148 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 568817002149 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 568817002150 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 568817002151 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 568817002152 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568817002153 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 568817002154 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568817002155 DNA binding residues [nucleotide binding] 568817002156 DNA primase; Validated; Region: dnaG; PRK05667 568817002157 CHC2 zinc finger; Region: zf-CHC2; pfam01807 568817002158 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 568817002159 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 568817002160 active site 568817002161 metal binding site [ion binding]; metal-binding site 568817002162 interdomain interaction site; other site 568817002163 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 568817002164 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 568817002165 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 568817002166 UGMP family protein; Validated; Region: PRK09604 568817002167 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 568817002168 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 568817002169 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 568817002170 active site 568817002171 NTP binding site [chemical binding]; other site 568817002172 metal binding triad [ion binding]; metal-binding site 568817002173 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 568817002174 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 568817002175 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 568817002176 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 568817002177 putative ribose interaction site [chemical binding]; other site 568817002178 putative ADP binding site [chemical binding]; other site 568817002179 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 568817002180 active site 568817002181 nucleotide binding site [chemical binding]; other site 568817002182 HIGH motif; other site 568817002183 KMSKS motif; other site 568817002184 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 568817002185 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 568817002186 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 568817002187 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 568817002188 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 568817002189 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 568817002190 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 568817002191 dimer interface [polypeptide binding]; other site 568817002192 ADP-ribose binding site [chemical binding]; other site 568817002193 active site 568817002194 nudix motif; other site 568817002195 metal binding site [ion binding]; metal-binding site 568817002196 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 568817002197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568817002198 Mg2+ binding site [ion binding]; other site 568817002199 G-X-G motif; other site 568817002200 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 568817002201 anchoring element; other site 568817002202 dimer interface [polypeptide binding]; other site 568817002203 ATP binding site [chemical binding]; other site 568817002204 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 568817002205 active site 568817002206 metal binding site [ion binding]; metal-binding site 568817002207 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 568817002208 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 568817002209 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 568817002210 CAP-like domain; other site 568817002211 active site 568817002212 primary dimer interface [polypeptide binding]; other site 568817002213 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 568817002214 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 568817002215 hinge; other site 568817002216 active site 568817002217 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 568817002218 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 568817002219 anti sigma factor interaction site; other site 568817002220 regulatory phosphorylation site [posttranslational modification]; other site 568817002221 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 568817002222 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 568817002223 mce related protein; Region: MCE; pfam02470 568817002224 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 568817002225 conserved hypothetical integral membrane protein; Region: TIGR00056 568817002226 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 568817002227 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 568817002228 Walker A/P-loop; other site 568817002229 ATP binding site [chemical binding]; other site 568817002230 Q-loop/lid; other site 568817002231 ABC transporter signature motif; other site 568817002232 Walker B; other site 568817002233 D-loop; other site 568817002234 H-loop/switch region; other site 568817002235 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 568817002236 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 568817002237 putative active site [active] 568817002238 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 568817002239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 568817002240 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 568817002241 OstA-like protein; Region: OstA; cl00844 568817002242 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 568817002243 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 568817002244 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 568817002245 Walker A/P-loop; other site 568817002246 ATP binding site [chemical binding]; other site 568817002247 Q-loop/lid; other site 568817002248 ABC transporter signature motif; other site 568817002249 Walker B; other site 568817002250 D-loop; other site 568817002251 H-loop/switch region; other site 568817002252 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 568817002253 active site 568817002254 phosphorylation site [posttranslational modification] 568817002255 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 568817002256 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 568817002257 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 568817002258 dimer interface [polypeptide binding]; other site 568817002259 active site 568817002260 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 568817002261 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 568817002262 Tetramer interface [polypeptide binding]; other site 568817002263 active site 568817002264 FMN-binding site [chemical binding]; other site 568817002265 HemK family putative methylases; Region: hemK_fam; TIGR00536 568817002266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568817002267 S-adenosylmethionine binding site [chemical binding]; other site 568817002268 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 568817002269 5S rRNA interface [nucleotide binding]; other site 568817002270 CTC domain interface [polypeptide binding]; other site 568817002271 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 568817002272 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568817002273 active site 568817002274 phosphorylation site [posttranslational modification] 568817002275 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 568817002276 dimerization domain swap beta strand [polypeptide binding]; other site 568817002277 regulatory protein interface [polypeptide binding]; other site 568817002278 active site 568817002279 regulatory phosphorylation site [posttranslational modification]; other site 568817002280 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 568817002281 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 568817002282 putative substrate binding site [chemical binding]; other site 568817002283 putative ATP binding site [chemical binding]; other site 568817002284 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 568817002285 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 568817002286 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 568817002287 active site 568817002288 P-loop; other site 568817002289 phosphorylation site [posttranslational modification] 568817002290 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 568817002291 endonuclease IV; Provisional; Region: PRK01060 568817002292 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 568817002293 AP (apurinic/apyrimidinic) site pocket; other site 568817002294 DNA interaction; other site 568817002295 Metal-binding active site; metal-binding site 568817002296 Predicted membrane protein [Function unknown]; Region: COG2855 568817002297 lysine transporter; Provisional; Region: PRK10836 568817002298 putative antibiotic transporter; Provisional; Region: PRK10739 568817002299 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 568817002300 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 568817002301 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 568817002302 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 568817002303 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 568817002304 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 568817002305 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 568817002306 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 568817002307 G1 box; other site 568817002308 GTP/Mg2+ binding site [chemical binding]; other site 568817002309 Switch I region; other site 568817002310 G2 box; other site 568817002311 G3 box; other site 568817002312 Switch II region; other site 568817002313 G4 box; other site 568817002314 G5 box; other site 568817002315 Nucleoside recognition; Region: Gate; pfam07670 568817002316 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 568817002317 Nucleoside recognition; Region: Gate; pfam07670 568817002318 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 568817002319 osmolarity response regulator; Provisional; Region: ompR; PRK09468 568817002320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568817002321 active site 568817002322 phosphorylation site [posttranslational modification] 568817002323 intermolecular recognition site; other site 568817002324 dimerization interface [polypeptide binding]; other site 568817002325 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568817002326 DNA binding site [nucleotide binding] 568817002327 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 568817002328 Transglycosylase; Region: Transgly; pfam00912 568817002329 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 568817002330 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 568817002331 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 568817002332 active site 568817002333 HIGH motif; other site 568817002334 dimer interface [polypeptide binding]; other site 568817002335 KMSKS motif; other site 568817002336 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 568817002337 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 568817002338 substrate binding site [chemical binding]; other site 568817002339 hexamer interface [polypeptide binding]; other site 568817002340 metal binding site [ion binding]; metal-binding site 568817002341 hypothetical protein; Reviewed; Region: PRK11901 568817002342 cell division protein DamX; Validated; Region: PRK10905 568817002343 shikimate kinase; Reviewed; Region: aroK; PRK00131 568817002344 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 568817002345 ADP binding site [chemical binding]; other site 568817002346 magnesium binding site [ion binding]; other site 568817002347 putative shikimate binding site; other site 568817002348 putative transporter; Provisional; Region: PRK03699 568817002349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568817002350 putative substrate translocation pore; other site 568817002351 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 568817002352 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 568817002353 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 568817002354 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 568817002355 sulfur relay protein TusC; Validated; Region: PRK00211 568817002356 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 568817002357 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 568817002358 S17 interaction site [polypeptide binding]; other site 568817002359 S8 interaction site; other site 568817002360 16S rRNA interaction site [nucleotide binding]; other site 568817002361 streptomycin interaction site [chemical binding]; other site 568817002362 23S rRNA interaction site [nucleotide binding]; other site 568817002363 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 568817002364 30S ribosomal protein S7; Validated; Region: PRK05302 568817002365 elongation factor G; Reviewed; Region: PRK00007 568817002366 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 568817002367 G1 box; other site 568817002368 putative GEF interaction site [polypeptide binding]; other site 568817002369 GTP/Mg2+ binding site [chemical binding]; other site 568817002370 Switch I region; other site 568817002371 G2 box; other site 568817002372 G3 box; other site 568817002373 Switch II region; other site 568817002374 G4 box; other site 568817002375 G5 box; other site 568817002376 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 568817002377 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 568817002378 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 568817002379 elongation factor Tu; Reviewed; Region: PRK00049 568817002380 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 568817002381 G1 box; other site 568817002382 GEF interaction site [polypeptide binding]; other site 568817002383 GTP/Mg2+ binding site [chemical binding]; other site 568817002384 Switch I region; other site 568817002385 G2 box; other site 568817002386 G3 box; other site 568817002387 Switch II region; other site 568817002388 G4 box; other site 568817002389 G5 box; other site 568817002390 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 568817002391 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 568817002392 Antibiotic Binding Site [chemical binding]; other site 568817002393 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 568817002394 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 568817002395 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 568817002396 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 568817002397 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 568817002398 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 568817002399 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 568817002400 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 568817002401 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 568817002402 protein-rRNA interface [nucleotide binding]; other site 568817002403 putative translocon binding site; other site 568817002404 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 568817002405 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 568817002406 G-X-X-G motif; other site 568817002407 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 568817002408 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 568817002409 23S rRNA interface [nucleotide binding]; other site 568817002410 5S rRNA interface [nucleotide binding]; other site 568817002411 putative antibiotic binding site [chemical binding]; other site 568817002412 L25 interface [polypeptide binding]; other site 568817002413 L27 interface [polypeptide binding]; other site 568817002414 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 568817002415 putative translocon interaction site; other site 568817002416 signal recognition particle (SRP54) interaction site; other site 568817002417 L23 interface [polypeptide binding]; other site 568817002418 trigger factor interaction site; other site 568817002419 23S rRNA interface [nucleotide binding]; other site 568817002420 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 568817002421 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 568817002422 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 568817002423 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 568817002424 RNA binding site [nucleotide binding]; other site 568817002425 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 568817002426 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 568817002427 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 568817002428 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 568817002429 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 568817002430 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 568817002431 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 568817002432 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 568817002433 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 568817002434 23S rRNA interface [nucleotide binding]; other site 568817002435 5S rRNA interface [nucleotide binding]; other site 568817002436 L27 interface [polypeptide binding]; other site 568817002437 L5 interface [polypeptide binding]; other site 568817002438 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 568817002439 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 568817002440 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 568817002441 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 568817002442 23S rRNA binding site [nucleotide binding]; other site 568817002443 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 568817002444 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 568817002445 SecY translocase; Region: SecY; pfam00344 568817002446 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 568817002447 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 568817002448 30S ribosomal protein S13; Region: bact_S13; TIGR03631 568817002449 30S ribosomal protein S11; Validated; Region: PRK05309 568817002450 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 568817002451 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 568817002452 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568817002453 RNA binding surface [nucleotide binding]; other site 568817002454 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 568817002455 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 568817002456 alphaNTD homodimer interface [polypeptide binding]; other site 568817002457 alphaNTD - beta interaction site [polypeptide binding]; other site 568817002458 alphaNTD - beta' interaction site [polypeptide binding]; other site 568817002459 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 568817002460 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 568817002461 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 568817002462 triosephosphate isomerase; Provisional; Region: PRK14567 568817002463 substrate binding site [chemical binding]; other site 568817002464 dimer interface [polypeptide binding]; other site 568817002465 catalytic triad [active] 568817002466 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568817002467 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 568817002468 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 568817002469 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 568817002470 active site 568817002471 ADP/pyrophosphate binding site [chemical binding]; other site 568817002472 dimerization interface [polypeptide binding]; other site 568817002473 allosteric effector site; other site 568817002474 fructose-1,6-bisphosphate binding site; other site 568817002475 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 568817002476 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 568817002477 active site 568817002478 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 568817002479 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 568817002480 domain interfaces; other site 568817002481 active site 568817002482 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 568817002483 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 568817002484 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 568817002485 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 568817002486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568817002487 motif II; other site 568817002488 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 568817002489 Part of AAA domain; Region: AAA_19; pfam13245 568817002490 Family description; Region: UvrD_C_2; pfam13538 568817002491 putative hydrolase; Provisional; Region: PRK10976 568817002492 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568817002493 active site 568817002494 motif I; other site 568817002495 motif II; other site 568817002496 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 568817002497 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 568817002498 CPxP motif; other site 568817002499 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 568817002500 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 568817002501 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 568817002502 P loop; other site 568817002503 GTP binding site [chemical binding]; other site 568817002504 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 568817002505 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 568817002506 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568817002507 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568817002508 DNA binding residues [nucleotide binding] 568817002509 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 568817002510 RmuC family; Region: RmuC; pfam02646 568817002511 transcription termination factor Rho; Provisional; Region: rho; PRK09376 568817002512 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 568817002513 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 568817002514 RNA binding site [nucleotide binding]; other site 568817002515 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 568817002516 multimer interface [polypeptide binding]; other site 568817002517 Walker A motif; other site 568817002518 ATP binding site [chemical binding]; other site 568817002519 Walker B motif; other site 568817002520 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 568817002521 catalytic residues [active] 568817002522 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 568817002523 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 568817002524 FMN binding site [chemical binding]; other site 568817002525 active site 568817002526 catalytic residues [active] 568817002527 substrate binding site [chemical binding]; other site 568817002528 replicative DNA helicase; Provisional; Region: PRK08006 568817002529 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 568817002530 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 568817002531 Walker A motif; other site 568817002532 ATP binding site [chemical binding]; other site 568817002533 Walker B motif; other site 568817002534 DNA binding loops [nucleotide binding] 568817002535 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 568817002536 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 568817002537 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 568817002538 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 568817002539 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 568817002540 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 568817002541 dimer interface [polypeptide binding]; other site 568817002542 ssDNA binding site [nucleotide binding]; other site 568817002543 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568817002544 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 568817002545 active site 568817002546 dimer interface [polypeptide binding]; other site 568817002547 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 568817002548 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 568817002549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568817002550 S-adenosylmethionine binding site [chemical binding]; other site 568817002551 oligopeptidase A; Provisional; Region: PRK10911 568817002552 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 568817002553 active site 568817002554 Zn binding site [ion binding]; other site 568817002555 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 568817002556 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 568817002557 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 568817002558 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 568817002559 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 568817002560 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 568817002561 substrate binding site [chemical binding]; other site 568817002562 active site 568817002563 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 568817002564 ThiC-associated domain; Region: ThiC-associated; pfam13667 568817002565 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 568817002566 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 568817002567 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 568817002568 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 568817002569 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 568817002570 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 568817002571 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 568817002572 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 568817002573 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 568817002574 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 568817002575 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 568817002576 DNA binding site [nucleotide binding] 568817002577 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 568817002578 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 568817002579 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 568817002580 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 568817002581 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 568817002582 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 568817002583 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 568817002584 RPB3 interaction site [polypeptide binding]; other site 568817002585 RPB1 interaction site [polypeptide binding]; other site 568817002586 RPB11 interaction site [polypeptide binding]; other site 568817002587 RPB10 interaction site [polypeptide binding]; other site 568817002588 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 568817002589 core dimer interface [polypeptide binding]; other site 568817002590 peripheral dimer interface [polypeptide binding]; other site 568817002591 L10 interface [polypeptide binding]; other site 568817002592 L11 interface [polypeptide binding]; other site 568817002593 putative EF-Tu interaction site [polypeptide binding]; other site 568817002594 putative EF-G interaction site [polypeptide binding]; other site 568817002595 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 568817002596 23S rRNA interface [nucleotide binding]; other site 568817002597 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 568817002598 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 568817002599 mRNA/rRNA interface [nucleotide binding]; other site 568817002600 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 568817002601 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 568817002602 23S rRNA interface [nucleotide binding]; other site 568817002603 L7/L12 interface [polypeptide binding]; other site 568817002604 putative thiostrepton binding site; other site 568817002605 L25 interface [polypeptide binding]; other site 568817002606 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 568817002607 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 568817002608 putative homodimer interface [polypeptide binding]; other site 568817002609 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 568817002610 heterodimer interface [polypeptide binding]; other site 568817002611 homodimer interface [polypeptide binding]; other site 568817002612 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 568817002613 pantothenate kinase; Provisional; Region: PRK05439 568817002614 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 568817002615 ATP-binding site [chemical binding]; other site 568817002616 CoA-binding site [chemical binding]; other site 568817002617 Mg2+-binding site [ion binding]; other site 568817002618 Biotin operon repressor [Transcription]; Region: BirA; COG1654 568817002619 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 568817002620 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 568817002621 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 568817002622 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 568817002623 FAD binding domain; Region: FAD_binding_4; pfam01565 568817002624 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 568817002625 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 568817002626 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568817002627 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 568817002628 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 568817002629 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 568817002630 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568817002631 carboxyltransferase (CT) interaction site; other site 568817002632 biotinylation site [posttranslational modification]; other site 568817002633 rod shape-determining protein MreB; Provisional; Region: PRK13927 568817002634 MreB and similar proteins; Region: MreB_like; cd10225 568817002635 nucleotide binding site [chemical binding]; other site 568817002636 Mg binding site [ion binding]; other site 568817002637 putative protofilament interaction site [polypeptide binding]; other site 568817002638 RodZ interaction site [polypeptide binding]; other site 568817002639 rod shape-determining protein MreC; Region: mreC; TIGR00219 568817002640 rod shape-determining protein MreC; Region: MreC; pfam04085 568817002641 rod shape-determining protein MreD; Region: MreD; cl01087 568817002642 hypothetical protein; Provisional; Region: PRK10899 568817002643 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 568817002644 primosome assembly protein PriA; Validated; Region: PRK05580 568817002645 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568817002646 ATP binding site [chemical binding]; other site 568817002647 putative Mg++ binding site [ion binding]; other site 568817002648 helicase superfamily c-terminal domain; Region: HELICc; smart00490 568817002649 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 568817002650 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 568817002651 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 568817002652 HIGH motif; other site 568817002653 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 568817002654 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 568817002655 active site 568817002656 KMSKS motif; other site 568817002657 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 568817002658 tRNA binding surface [nucleotide binding]; other site 568817002659 anticodon binding site; other site 568817002660 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 568817002661 DNA polymerase III subunit chi; Validated; Region: PRK05728 568817002662 multifunctional aminopeptidase A; Provisional; Region: PRK00913 568817002663 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 568817002664 interface (dimer of trimers) [polypeptide binding]; other site 568817002665 Substrate-binding/catalytic site; other site 568817002666 Zn-binding sites [ion binding]; other site 568817002667 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 568817002668 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 568817002669 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 568817002670 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 568817002671 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 568817002672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568817002673 ATP binding site [chemical binding]; other site 568817002674 Mg2+ binding site [ion binding]; other site 568817002675 G-X-G motif; other site 568817002676 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 568817002677 anchoring element; other site 568817002678 dimer interface [polypeptide binding]; other site 568817002679 ATP binding site [chemical binding]; other site 568817002680 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 568817002681 active site 568817002682 putative metal-binding site [ion binding]; other site 568817002683 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 568817002684 DNA polymerase III subunit beta; Validated; Region: PRK05643 568817002685 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 568817002686 putative DNA binding surface [nucleotide binding]; other site 568817002687 dimer interface [polypeptide binding]; other site 568817002688 beta-clamp/clamp loader binding surface; other site 568817002689 beta-clamp/translesion DNA polymerase binding surface; other site 568817002690 DnaA N-terminal domain; Region: DnaA_N; pfam11638 568817002691 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 568817002692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568817002693 Walker A motif; other site 568817002694 ATP binding site [chemical binding]; other site 568817002695 Walker B motif; other site 568817002696 arginine finger; other site 568817002697 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 568817002698 DnaA box-binding interface [nucleotide binding]; other site 568817002699 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 568817002700 ribonuclease P; Reviewed; Region: rnpA; PRK01732 568817002701 hypothetical protein; Validated; Region: PRK00041 568817002702 membrane protein insertase; Provisional; Region: PRK01318 568817002703 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 568817002704 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 568817002705 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 568817002706 trmE is a tRNA modification GTPase; Region: trmE; cd04164 568817002707 G1 box; other site 568817002708 GTP/Mg2+ binding site [chemical binding]; other site 568817002709 Switch I region; other site 568817002710 G2 box; other site 568817002711 Switch II region; other site 568817002712 G3 box; other site 568817002713 G4 box; other site 568817002714 G5 box; other site 568817002715 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 568817002716 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 568817002717 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 568817002718 catalytic site [active] 568817002719 G-X2-G-X-G-K; other site 568817002720 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 568817002721 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 568817002722 G1 box; other site 568817002723 putative GEF interaction site [polypeptide binding]; other site 568817002724 GTP/Mg2+ binding site [chemical binding]; other site 568817002725 Switch I region; other site 568817002726 G2 box; other site 568817002727 G3 box; other site 568817002728 Switch II region; other site 568817002729 G4 box; other site 568817002730 G5 box; other site 568817002731 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 568817002732 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 568817002733 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 568817002734 G1 box; other site 568817002735 GTP/Mg2+ binding site [chemical binding]; other site 568817002736 Switch I region; other site 568817002737 G2 box; other site 568817002738 G3 box; other site 568817002739 Switch II region; other site 568817002740 G4 box; other site 568817002741 G5 box; other site 568817002742 DNA polymerase I; Provisional; Region: PRK05755 568817002743 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 568817002744 active site 568817002745 metal binding site 1 [ion binding]; metal-binding site 568817002746 putative 5' ssDNA interaction site; other site 568817002747 metal binding site 3; metal-binding site 568817002748 metal binding site 2 [ion binding]; metal-binding site 568817002749 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 568817002750 putative DNA binding site [nucleotide binding]; other site 568817002751 putative metal binding site [ion binding]; other site 568817002752 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 568817002753 active site 568817002754 catalytic site [active] 568817002755 substrate binding site [chemical binding]; other site 568817002756 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 568817002757 active site 568817002758 DNA binding site [nucleotide binding] 568817002759 catalytic site [active] 568817002760 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 568817002761 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 568817002762 catalytic residues [active] 568817002763 hinge region; other site 568817002764 alpha helical domain; other site 568817002765 glutamate racemase; Provisional; Region: PRK00865 568817002766 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 568817002767 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 568817002768 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 568817002769 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 568817002770 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 568817002771 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932