-- dump date 20140620_064702 -- class Genbank::misc_feature -- table misc_feature_note -- id note 351745000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 351745000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 351745000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745000004 Walker A motif; other site 351745000005 ATP binding site [chemical binding]; other site 351745000006 Walker B motif; other site 351745000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 351745000008 arginine finger; other site 351745000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 351745000010 DnaA box-binding interface [nucleotide binding]; other site 351745000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 351745000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 351745000013 putative DNA binding surface [nucleotide binding]; other site 351745000014 dimer interface [polypeptide binding]; other site 351745000015 beta-clamp/clamp loader binding surface; other site 351745000016 beta-clamp/translesion DNA polymerase binding surface; other site 351745000017 recombination protein F; Reviewed; Region: recF; PRK00064 351745000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745000019 Walker A/P-loop; other site 351745000020 ATP binding site [chemical binding]; other site 351745000021 Q-loop/lid; other site 351745000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745000023 ABC transporter signature motif; other site 351745000024 Walker B; other site 351745000025 D-loop; other site 351745000026 H-loop/switch region; other site 351745000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 351745000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745000029 ATP binding site [chemical binding]; other site 351745000030 Mg2+ binding site [ion binding]; other site 351745000031 G-X-G motif; other site 351745000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 351745000033 anchoring element; other site 351745000034 dimer interface [polypeptide binding]; other site 351745000035 ATP binding site [chemical binding]; other site 351745000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 351745000037 active site 351745000038 putative metal-binding site [ion binding]; other site 351745000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 351745000040 HDOD domain; Region: HDOD; pfam08668 351745000041 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 351745000042 Zn2+ binding site [ion binding]; other site 351745000043 Mg2+ binding site [ion binding]; other site 351745000044 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 351745000045 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 351745000046 dimer interface [polypeptide binding]; other site 351745000047 motif 1; other site 351745000048 active site 351745000049 motif 2; other site 351745000050 motif 3; other site 351745000051 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 351745000052 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 351745000053 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 351745000054 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 351745000055 Amidohydrolase; Region: Amidohydro_5; pfam13594 351745000056 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 351745000057 active site 351745000058 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 351745000059 MOSC domain; Region: MOSC; pfam03473 351745000060 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 351745000061 CPxP motif; other site 351745000062 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 351745000063 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 351745000064 dimer interface [polypeptide binding]; other site 351745000065 active site 351745000066 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 351745000067 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 351745000068 substrate binding site [chemical binding]; other site 351745000069 oxyanion hole (OAH) forming residues; other site 351745000070 trimer interface [polypeptide binding]; other site 351745000071 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 351745000072 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 351745000073 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 351745000074 proline dipeptidase; Provisional; Region: PRK13607 351745000075 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 351745000076 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 351745000077 active site 351745000078 hypothetical protein; Provisional; Region: PRK11568 351745000079 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 351745000080 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 351745000081 Cation transport protein; Region: TrkH; cl17365 351745000082 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 351745000083 Flavodoxin domain; Region: Flavodoxin_5; cl17428 351745000084 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 351745000085 dimerization interface [polypeptide binding]; other site 351745000086 putative DNA binding site [nucleotide binding]; other site 351745000087 putative Zn2+ binding site [ion binding]; other site 351745000088 Flavodoxin domain; Region: Flavodoxin_5; cl17428 351745000089 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 351745000090 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 351745000091 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 351745000092 TrkA-N domain; Region: TrkA_N; pfam02254 351745000093 TrkA-C domain; Region: TrkA_C; pfam02080 351745000094 TrkA-N domain; Region: TrkA_N; pfam02254 351745000095 TrkA-C domain; Region: TrkA_C; pfam02080 351745000096 16S rRNA methyltransferase B; Provisional; Region: PRK10901 351745000097 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 351745000098 putative RNA binding site [nucleotide binding]; other site 351745000099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745000100 S-adenosylmethionine binding site [chemical binding]; other site 351745000101 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 351745000102 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 351745000103 putative active site [active] 351745000104 substrate binding site [chemical binding]; other site 351745000105 putative cosubstrate binding site; other site 351745000106 catalytic site [active] 351745000107 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 351745000108 substrate binding site [chemical binding]; other site 351745000109 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 351745000110 active site 351745000111 catalytic residues [active] 351745000112 metal binding site [ion binding]; metal-binding site 351745000113 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 351745000114 DNA protecting protein DprA; Region: dprA; TIGR00732 351745000115 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 351745000116 Protein of unknown function (DUF494); Region: DUF494; pfam04361 351745000117 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 351745000118 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 351745000119 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 351745000120 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 351745000121 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 351745000122 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 351745000123 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 351745000124 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 351745000125 apolar tunnel; other site 351745000126 heme binding site [chemical binding]; other site 351745000127 dimerization interface [polypeptide binding]; other site 351745000128 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 351745000129 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 351745000130 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 351745000131 shikimate binding site; other site 351745000132 NAD(P) binding site [chemical binding]; other site 351745000133 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 351745000134 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 351745000135 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 351745000136 trimer interface [polypeptide binding]; other site 351745000137 putative metal binding site [ion binding]; other site 351745000138 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745000139 PAS fold; Region: PAS_3; pfam08447 351745000140 putative active site [active] 351745000141 heme pocket [chemical binding]; other site 351745000142 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745000143 metal binding site [ion binding]; metal-binding site 351745000144 active site 351745000145 I-site; other site 351745000146 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745000147 lysophospholipase L2; Provisional; Region: PRK10749 351745000148 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 351745000149 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 351745000150 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 351745000151 adenosine deaminase; Provisional; Region: PRK09358 351745000152 active site 351745000153 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 351745000154 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351745000155 FeS/SAM binding site; other site 351745000156 HemN C-terminal domain; Region: HemN_C; pfam06969 351745000157 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 351745000158 Der GTPase activator (YihI); Region: YihI; pfam04220 351745000159 Methyltransferase domain; Region: Methyltransf_23; pfam13489 351745000160 Cytochrome c553 [Energy production and conversion]; Region: COG2863 351745000161 Cytochrome c; Region: Cytochrom_C; cl11414 351745000162 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 351745000163 G1 box; other site 351745000164 GTP/Mg2+ binding site [chemical binding]; other site 351745000165 Switch I region; other site 351745000166 G2 box; other site 351745000167 G3 box; other site 351745000168 Switch II region; other site 351745000169 G4 box; other site 351745000170 G5 box; other site 351745000171 DNA polymerase I; Provisional; Region: PRK05755 351745000172 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 351745000173 active site 351745000174 metal binding site 1 [ion binding]; metal-binding site 351745000175 putative 5' ssDNA interaction site; other site 351745000176 metal binding site 3; metal-binding site 351745000177 metal binding site 2 [ion binding]; metal-binding site 351745000178 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 351745000179 putative DNA binding site [nucleotide binding]; other site 351745000180 putative metal binding site [ion binding]; other site 351745000181 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 351745000182 active site 351745000183 catalytic site [active] 351745000184 substrate binding site [chemical binding]; other site 351745000185 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 351745000186 active site 351745000187 DNA binding site [nucleotide binding] 351745000188 catalytic site [active] 351745000189 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 351745000190 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 351745000191 conserved cys residue [active] 351745000192 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 351745000193 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 351745000194 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 351745000195 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 351745000196 active site residue [active] 351745000197 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 351745000198 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 351745000199 NAD(P) binding site [chemical binding]; other site 351745000200 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 351745000201 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 351745000202 substrate-cofactor binding pocket; other site 351745000203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745000204 catalytic residue [active] 351745000205 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 351745000206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 351745000207 Bacterial transcriptional repressor; Region: TetR; pfam13972 351745000208 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 351745000209 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 351745000210 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 351745000211 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293 351745000212 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 351745000213 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 351745000214 putative active site [active] 351745000215 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 351745000216 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 351745000217 putative ADP-binding pocket [chemical binding]; other site 351745000218 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 351745000219 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 351745000220 active site 351745000221 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 351745000222 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 351745000223 putative ADP-binding pocket [chemical binding]; other site 351745000224 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 351745000225 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 351745000226 Sulfatase; Region: Sulfatase; cl17466 351745000227 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 351745000228 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 351745000229 active site 351745000230 (T/H)XGH motif; other site 351745000231 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 351745000232 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 351745000233 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 351745000234 putative NAD(P) binding site [chemical binding]; other site 351745000235 active site 351745000236 putative substrate binding site [chemical binding]; other site 351745000237 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 351745000238 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 351745000239 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 351745000240 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 351745000241 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 351745000242 Ligand binding site; other site 351745000243 Putative Catalytic site; other site 351745000244 DXD motif; other site 351745000245 Uncharacterized conserved protein [Function unknown]; Region: COG0398 351745000246 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 351745000247 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 351745000248 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 351745000249 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 351745000250 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 351745000251 DNA binding site [nucleotide binding] 351745000252 catalytic residue [active] 351745000253 H2TH interface [polypeptide binding]; other site 351745000254 putative catalytic residues [active] 351745000255 turnover-facilitating residue; other site 351745000256 intercalation triad [nucleotide binding]; other site 351745000257 8OG recognition residue [nucleotide binding]; other site 351745000258 putative reading head residues; other site 351745000259 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 351745000260 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 351745000261 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 351745000262 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351745000263 FeS/SAM binding site; other site 351745000264 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 351745000265 putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional; Region: PRK14491 351745000266 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 351745000267 Walker A motif; other site 351745000268 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 351745000269 dimer interface [polypeptide binding]; other site 351745000270 putative functional site; other site 351745000271 putative MPT binding site; other site 351745000272 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 351745000273 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 351745000274 GTP binding site; other site 351745000275 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 351745000276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745000277 Walker A/P-loop; other site 351745000278 ATP binding site [chemical binding]; other site 351745000279 Q-loop/lid; other site 351745000280 ABC transporter signature motif; other site 351745000281 Walker B; other site 351745000282 D-loop; other site 351745000283 H-loop/switch region; other site 351745000284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351745000285 dimer interface [polypeptide binding]; other site 351745000286 conserved gate region; other site 351745000287 putative PBP binding loops; other site 351745000288 ABC-ATPase subunit interface; other site 351745000289 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 351745000290 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 351745000291 dimerization interface [polypeptide binding]; other site 351745000292 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 351745000293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745000294 active site 351745000295 phosphorylation site [posttranslational modification] 351745000296 intermolecular recognition site; other site 351745000297 dimerization interface [polypeptide binding]; other site 351745000298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745000299 Walker A motif; other site 351745000300 ATP binding site [chemical binding]; other site 351745000301 Walker B motif; other site 351745000302 arginine finger; other site 351745000303 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 351745000304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 351745000305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745000306 dimer interface [polypeptide binding]; other site 351745000307 phosphorylation site [posttranslational modification] 351745000308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745000309 ATP binding site [chemical binding]; other site 351745000310 G-X-G motif; other site 351745000311 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745000312 Coenzyme A binding pocket [chemical binding]; other site 351745000313 hypothetical protein; Provisional; Region: PRK11212 351745000314 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 351745000315 chorismate binding enzyme; Region: Chorismate_bind; cl10555 351745000316 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 351745000317 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 351745000318 Walker A/P-loop; other site 351745000319 ATP binding site [chemical binding]; other site 351745000320 Q-loop/lid; other site 351745000321 ABC transporter signature motif; other site 351745000322 Walker B; other site 351745000323 D-loop; other site 351745000324 H-loop/switch region; other site 351745000325 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 351745000326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745000327 Walker A/P-loop; other site 351745000328 ATP binding site [chemical binding]; other site 351745000329 Q-loop/lid; other site 351745000330 ABC transporter signature motif; other site 351745000331 Walker B; other site 351745000332 D-loop; other site 351745000333 H-loop/switch region; other site 351745000334 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 351745000335 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 351745000336 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 351745000337 Zn2+ binding site [ion binding]; other site 351745000338 Mg2+ binding site [ion binding]; other site 351745000339 Paraquat-inducible protein A; Region: PqiA; pfam04403 351745000340 Predicted membrane protein [Function unknown]; Region: COG2855 351745000341 malate synthase; Provisional; Region: PRK08951 351745000342 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 351745000343 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 351745000344 non-specific DNA binding site [nucleotide binding]; other site 351745000345 salt bridge; other site 351745000346 sequence-specific DNA binding site [nucleotide binding]; other site 351745000347 Domain of unknown function (DUF955); Region: DUF955; cl01076 351745000348 Protein of unknown function (DUF3612); Region: DUF3612; pfam12268 351745000349 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 351745000350 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 351745000351 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 351745000352 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 351745000353 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745000354 N-terminal plug; other site 351745000355 ligand-binding site [chemical binding]; other site 351745000356 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 351745000357 UbiA prenyltransferase family; Region: UbiA; pfam01040 351745000358 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 351745000359 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 351745000360 Subunit I/III interface [polypeptide binding]; other site 351745000361 Subunit III/IV interface [polypeptide binding]; other site 351745000362 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 351745000363 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 351745000364 D-pathway; other site 351745000365 Putative ubiquinol binding site [chemical binding]; other site 351745000366 Low-spin heme (heme b) binding site [chemical binding]; other site 351745000367 Putative water exit pathway; other site 351745000368 Binuclear center (heme o3/CuB) [ion binding]; other site 351745000369 K-pathway; other site 351745000370 Putative proton exit pathway; other site 351745000371 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 351745000372 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 351745000373 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 351745000374 MASE1; Region: MASE1; cl17823 351745000375 CHASE domain; Region: CHASE; pfam03924 351745000376 PAS domain S-box; Region: sensory_box; TIGR00229 351745000377 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745000378 putative active site [active] 351745000379 heme pocket [chemical binding]; other site 351745000380 PAS domain S-box; Region: sensory_box; TIGR00229 351745000381 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745000382 putative active site [active] 351745000383 heme pocket [chemical binding]; other site 351745000384 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745000385 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745000386 metal binding site [ion binding]; metal-binding site 351745000387 active site 351745000388 I-site; other site 351745000389 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745000390 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 351745000391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 351745000392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745000393 ATP binding site [chemical binding]; other site 351745000394 Mg2+ binding site [ion binding]; other site 351745000395 G-X-G motif; other site 351745000396 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 351745000397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745000398 active site 351745000399 phosphorylation site [posttranslational modification] 351745000400 intermolecular recognition site; other site 351745000401 dimerization interface [polypeptide binding]; other site 351745000402 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745000403 DNA binding site [nucleotide binding] 351745000404 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 351745000405 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 351745000406 catalytic triad [active] 351745000407 dimer interface [polypeptide binding]; other site 351745000408 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 351745000409 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745000410 dimerization interface [polypeptide binding]; other site 351745000411 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745000412 dimer interface [polypeptide binding]; other site 351745000413 putative CheW interface [polypeptide binding]; other site 351745000414 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 351745000415 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745000416 dimerization interface [polypeptide binding]; other site 351745000417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745000418 dimer interface [polypeptide binding]; other site 351745000419 phosphorylation site [posttranslational modification] 351745000420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745000421 ATP binding site [chemical binding]; other site 351745000422 Mg2+ binding site [ion binding]; other site 351745000423 G-X-G motif; other site 351745000424 osmolarity response regulator; Provisional; Region: ompR; PRK09468 351745000425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745000426 active site 351745000427 phosphorylation site [posttranslational modification] 351745000428 intermolecular recognition site; other site 351745000429 dimerization interface [polypeptide binding]; other site 351745000430 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745000431 DNA binding site [nucleotide binding] 351745000432 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 351745000433 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 351745000434 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 351745000435 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 351745000436 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 351745000437 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 351745000438 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 351745000439 RNA binding site [nucleotide binding]; other site 351745000440 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 351745000441 Sulfatase; Region: Sulfatase; pfam00884 351745000442 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 351745000443 DNA utilization protein GntX; Provisional; Region: PRK11595 351745000444 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 351745000445 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 351745000446 dimerization interface [polypeptide binding]; other site 351745000447 DNA binding residues [nucleotide binding] 351745000448 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 351745000449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745000450 active site 351745000451 phosphorylation site [posttranslational modification] 351745000452 intermolecular recognition site; other site 351745000453 dimerization interface [polypeptide binding]; other site 351745000454 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745000455 DNA binding site [nucleotide binding] 351745000456 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 351745000457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 351745000458 dimer interface [polypeptide binding]; other site 351745000459 phosphorylation site [posttranslational modification] 351745000460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745000461 ATP binding site [chemical binding]; other site 351745000462 Mg2+ binding site [ion binding]; other site 351745000463 G-X-G motif; other site 351745000464 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 351745000465 FMN-binding domain; Region: FMN_bind; pfam04205 351745000466 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 351745000467 L-aspartate oxidase; Provisional; Region: PRK06175 351745000468 Predicted oxidoreductase [General function prediction only]; Region: COG3573 351745000469 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 351745000470 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 351745000471 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 351745000472 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 351745000473 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 351745000474 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973 351745000475 putative active site [active] 351745000476 putative metal binding site [ion binding]; other site 351745000477 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 351745000478 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 351745000479 Cu(I) binding site [ion binding]; other site 351745000480 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 351745000481 UbiA prenyltransferase family; Region: UbiA; pfam01040 351745000482 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 351745000483 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 351745000484 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 351745000485 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 351745000486 Subunit III/VIIa interface [polypeptide binding]; other site 351745000487 Phospholipid binding site [chemical binding]; other site 351745000488 Subunit I/III interface [polypeptide binding]; other site 351745000489 Subunit III/VIb interface [polypeptide binding]; other site 351745000490 Subunit III/VIa interface; other site 351745000491 Subunit III/Vb interface [polypeptide binding]; other site 351745000492 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 351745000493 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 351745000494 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 351745000495 Subunit I/III interface [polypeptide binding]; other site 351745000496 D-pathway; other site 351745000497 Subunit I/VIIc interface [polypeptide binding]; other site 351745000498 Subunit I/IV interface [polypeptide binding]; other site 351745000499 Subunit I/II interface [polypeptide binding]; other site 351745000500 Low-spin heme (heme a) binding site [chemical binding]; other site 351745000501 Subunit I/VIIa interface [polypeptide binding]; other site 351745000502 Subunit I/VIa interface [polypeptide binding]; other site 351745000503 Dimer interface; other site 351745000504 Putative water exit pathway; other site 351745000505 Binuclear center (heme a3/CuB) [ion binding]; other site 351745000506 K-pathway; other site 351745000507 Subunit I/Vb interface [polypeptide binding]; other site 351745000508 Putative proton exit pathway; other site 351745000509 Subunit I/VIb interface; other site 351745000510 Subunit I/VIc interface [polypeptide binding]; other site 351745000511 Electron transfer pathway; other site 351745000512 Subunit I/VIIIb interface [polypeptide binding]; other site 351745000513 Subunit I/VIIb interface [polypeptide binding]; other site 351745000514 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 351745000515 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 351745000516 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 351745000517 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 351745000518 Cytochrome c; Region: Cytochrom_C; pfam00034 351745000519 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 351745000520 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 351745000521 Cell division inhibitor SulA; Region: SulA; cl01880 351745000522 LexA repressor; Validated; Region: PRK00215 351745000523 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 351745000524 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 351745000525 Catalytic site [active] 351745000526 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 351745000527 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 351745000528 putative acyl-acceptor binding pocket; other site 351745000529 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 351745000530 aromatic amino acid transport protein; Region: araaP; TIGR00837 351745000531 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 351745000532 B1 nucleotide binding pocket [chemical binding]; other site 351745000533 B2 nucleotide binding pocket [chemical binding]; other site 351745000534 CAS motifs; other site 351745000535 active site 351745000536 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 351745000537 FAD binding domain; Region: FAD_binding_4; pfam01565 351745000538 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 351745000539 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 351745000540 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 351745000541 dimerization interface [polypeptide binding]; other site 351745000542 putative Zn2+ binding site [ion binding]; other site 351745000543 putative DNA binding site [nucleotide binding]; other site 351745000544 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 351745000545 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 351745000546 pantothenate kinase; Provisional; Region: PRK05439 351745000547 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 351745000548 ATP-binding site [chemical binding]; other site 351745000549 CoA-binding site [chemical binding]; other site 351745000550 Mg2+-binding site [ion binding]; other site 351745000551 elongation factor Tu; Reviewed; Region: PRK00049 351745000552 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 351745000553 G1 box; other site 351745000554 GEF interaction site [polypeptide binding]; other site 351745000555 GTP/Mg2+ binding site [chemical binding]; other site 351745000556 Switch I region; other site 351745000557 G2 box; other site 351745000558 G3 box; other site 351745000559 Switch II region; other site 351745000560 G4 box; other site 351745000561 G5 box; other site 351745000562 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 351745000563 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 351745000564 Antibiotic Binding Site [chemical binding]; other site 351745000565 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 351745000566 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 351745000567 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 351745000568 putative homodimer interface [polypeptide binding]; other site 351745000569 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 351745000570 heterodimer interface [polypeptide binding]; other site 351745000571 homodimer interface [polypeptide binding]; other site 351745000572 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 351745000573 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 351745000574 23S rRNA interface [nucleotide binding]; other site 351745000575 L7/L12 interface [polypeptide binding]; other site 351745000576 putative thiostrepton binding site; other site 351745000577 L25 interface [polypeptide binding]; other site 351745000578 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 351745000579 mRNA/rRNA interface [nucleotide binding]; other site 351745000580 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 351745000581 23S rRNA interface [nucleotide binding]; other site 351745000582 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 351745000583 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 351745000584 core dimer interface [polypeptide binding]; other site 351745000585 peripheral dimer interface [polypeptide binding]; other site 351745000586 L10 interface [polypeptide binding]; other site 351745000587 L11 interface [polypeptide binding]; other site 351745000588 putative EF-Tu interaction site [polypeptide binding]; other site 351745000589 putative EF-G interaction site [polypeptide binding]; other site 351745000590 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 351745000591 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 351745000592 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 351745000593 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 351745000594 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 351745000595 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 351745000596 RPB3 interaction site [polypeptide binding]; other site 351745000597 RPB1 interaction site [polypeptide binding]; other site 351745000598 RPB11 interaction site [polypeptide binding]; other site 351745000599 RPB10 interaction site [polypeptide binding]; other site 351745000600 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 351745000601 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 351745000602 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 351745000603 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 351745000604 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 351745000605 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 351745000606 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 351745000607 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 351745000608 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 351745000609 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 351745000610 DNA binding site [nucleotide binding] 351745000611 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 351745000612 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 351745000613 S17 interaction site [polypeptide binding]; other site 351745000614 S8 interaction site; other site 351745000615 16S rRNA interaction site [nucleotide binding]; other site 351745000616 streptomycin interaction site [chemical binding]; other site 351745000617 23S rRNA interaction site [nucleotide binding]; other site 351745000618 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 351745000619 30S ribosomal protein S7; Validated; Region: PRK05302 351745000620 elongation factor G; Reviewed; Region: PRK00007 351745000621 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 351745000622 G1 box; other site 351745000623 putative GEF interaction site [polypeptide binding]; other site 351745000624 GTP/Mg2+ binding site [chemical binding]; other site 351745000625 Switch I region; other site 351745000626 G2 box; other site 351745000627 G3 box; other site 351745000628 Switch II region; other site 351745000629 G4 box; other site 351745000630 G5 box; other site 351745000631 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 351745000632 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 351745000633 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 351745000634 elongation factor Tu; Reviewed; Region: PRK00049 351745000635 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 351745000636 G1 box; other site 351745000637 GEF interaction site [polypeptide binding]; other site 351745000638 GTP/Mg2+ binding site [chemical binding]; other site 351745000639 Switch I region; other site 351745000640 G2 box; other site 351745000641 G3 box; other site 351745000642 Switch II region; other site 351745000643 G4 box; other site 351745000644 G5 box; other site 351745000645 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 351745000646 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 351745000647 Antibiotic Binding Site [chemical binding]; other site 351745000648 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 351745000649 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 351745000650 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 351745000651 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 351745000652 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 351745000653 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 351745000654 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 351745000655 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 351745000656 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 351745000657 putative translocon binding site; other site 351745000658 protein-rRNA interface [nucleotide binding]; other site 351745000659 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 351745000660 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 351745000661 G-X-X-G motif; other site 351745000662 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 351745000663 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 351745000664 23S rRNA interface [nucleotide binding]; other site 351745000665 5S rRNA interface [nucleotide binding]; other site 351745000666 putative antibiotic binding site [chemical binding]; other site 351745000667 L25 interface [polypeptide binding]; other site 351745000668 L27 interface [polypeptide binding]; other site 351745000669 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 351745000670 23S rRNA interface [nucleotide binding]; other site 351745000671 putative translocon interaction site; other site 351745000672 signal recognition particle (SRP54) interaction site; other site 351745000673 L23 interface [polypeptide binding]; other site 351745000674 trigger factor interaction site; other site 351745000675 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 351745000676 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 351745000677 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 351745000678 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 351745000679 RNA binding site [nucleotide binding]; other site 351745000680 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 351745000681 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 351745000682 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 351745000683 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 351745000684 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 351745000685 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 351745000686 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 351745000687 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 351745000688 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 351745000689 5S rRNA interface [nucleotide binding]; other site 351745000690 23S rRNA interface [nucleotide binding]; other site 351745000691 L5 interface [polypeptide binding]; other site 351745000692 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 351745000693 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 351745000694 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 351745000695 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 351745000696 23S rRNA binding site [nucleotide binding]; other site 351745000697 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 351745000698 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 351745000699 SecY translocase; Region: SecY; pfam00344 351745000700 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 351745000701 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 351745000702 30S ribosomal protein S13; Region: bact_S13; TIGR03631 351745000703 30S ribosomal protein S11; Validated; Region: PRK05309 351745000704 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 351745000705 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 351745000706 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 351745000707 RNA binding surface [nucleotide binding]; other site 351745000708 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 351745000709 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 351745000710 alphaNTD homodimer interface [polypeptide binding]; other site 351745000711 alphaNTD - beta interaction site [polypeptide binding]; other site 351745000712 alphaNTD - beta' interaction site [polypeptide binding]; other site 351745000713 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 351745000714 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 351745000715 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 351745000716 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 351745000717 heme exporter protein CcmC; Region: ccmC; TIGR01191 351745000718 heme exporter protein CcmB; Region: ccmB; TIGR01190 351745000719 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 351745000720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745000721 Walker A/P-loop; other site 351745000722 ATP binding site [chemical binding]; other site 351745000723 Q-loop/lid; other site 351745000724 ABC transporter signature motif; other site 351745000725 Walker B; other site 351745000726 D-loop; other site 351745000727 H-loop/switch region; other site 351745000728 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 351745000729 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 351745000730 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 351745000731 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 351745000732 binding surface 351745000733 TPR motif; other site 351745000734 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 351745000735 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 351745000736 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 351745000737 catalytic residues [active] 351745000738 central insert; other site 351745000739 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 351745000740 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 351745000741 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 351745000742 catalytic residues [active] 351745000743 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 351745000744 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 351745000745 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 351745000746 transmembrane helices; other site 351745000747 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 351745000748 Fumarase C-terminus; Region: Fumerase_C; pfam05683 351745000749 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 351745000750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745000751 active site 351745000752 phosphorylation site [posttranslational modification] 351745000753 intermolecular recognition site; other site 351745000754 dimerization interface [polypeptide binding]; other site 351745000755 HTH domain; Region: HTH_11; pfam08279 351745000756 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 351745000757 PAS domain; Region: PAS; smart00091 351745000758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745000759 ATP binding site [chemical binding]; other site 351745000760 Mg2+ binding site [ion binding]; other site 351745000761 G-X-G motif; other site 351745000762 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 351745000763 Iron-sulfur protein interface; other site 351745000764 proximal quinone binding site [chemical binding]; other site 351745000765 C-subunit interface; other site 351745000766 distal quinone binding site; other site 351745000767 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 351745000768 D-subunit interface [polypeptide binding]; other site 351745000769 Iron-sulfur protein interface; other site 351745000770 proximal quinone binding site [chemical binding]; other site 351745000771 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 351745000772 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 351745000773 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 351745000774 L-aspartate oxidase; Provisional; Region: PRK06175 351745000775 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 351745000776 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 351745000777 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745000778 Coenzyme A binding pocket [chemical binding]; other site 351745000779 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 351745000780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 351745000781 dimer interface [polypeptide binding]; other site 351745000782 phosphorylation site [posttranslational modification] 351745000783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745000784 ATP binding site [chemical binding]; other site 351745000785 Mg2+ binding site [ion binding]; other site 351745000786 G-X-G motif; other site 351745000787 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 351745000788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745000789 active site 351745000790 phosphorylation site [posttranslational modification] 351745000791 intermolecular recognition site; other site 351745000792 dimerization interface [polypeptide binding]; other site 351745000793 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745000794 DNA binding site [nucleotide binding] 351745000795 Predicted membrane protein [Function unknown]; Region: COG3212 351745000796 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 351745000797 Dihaem cytochrome c; Region: DHC; pfam09626 351745000798 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 351745000799 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 351745000800 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 351745000801 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 351745000802 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 351745000803 NAD(P) binding site [chemical binding]; other site 351745000804 catalytic residues [active] 351745000805 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 351745000806 GAF domain; Region: GAF; pfam01590 351745000807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745000808 Walker A motif; other site 351745000809 ATP binding site [chemical binding]; other site 351745000810 Walker B motif; other site 351745000811 arginine finger; other site 351745000812 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 351745000813 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745000814 dimerization interface [polypeptide binding]; other site 351745000815 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745000816 dimer interface [polypeptide binding]; other site 351745000817 phosphorylation site [posttranslational modification] 351745000818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745000819 ATP binding site [chemical binding]; other site 351745000820 Mg2+ binding site [ion binding]; other site 351745000821 G-X-G motif; other site 351745000822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745000823 active site 351745000824 phosphorylation site [posttranslational modification] 351745000825 intermolecular recognition site; other site 351745000826 dimerization interface [polypeptide binding]; other site 351745000827 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745000828 DNA binding site [nucleotide binding] 351745000829 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 351745000830 dimer interface [polypeptide binding]; other site 351745000831 Cation efflux family; Region: Cation_efflux; cl00316 351745000832 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 351745000833 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 351745000834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745000835 active site 351745000836 phosphorylation site [posttranslational modification] 351745000837 intermolecular recognition site; other site 351745000838 dimerization interface [polypeptide binding]; other site 351745000839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745000840 Walker A motif; other site 351745000841 ATP binding site [chemical binding]; other site 351745000842 Walker B motif; other site 351745000843 arginine finger; other site 351745000844 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 351745000845 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 351745000846 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 351745000847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745000848 dimer interface [polypeptide binding]; other site 351745000849 phosphorylation site [posttranslational modification] 351745000850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745000851 ATP binding site [chemical binding]; other site 351745000852 Mg2+ binding site [ion binding]; other site 351745000853 G-X-G motif; other site 351745000854 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 351745000855 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 351745000856 N-terminal domain interface [polypeptide binding]; other site 351745000857 dimer interface [polypeptide binding]; other site 351745000858 substrate binding pocket (H-site) [chemical binding]; other site 351745000859 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 351745000860 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 351745000861 putative C-terminal domain interface [polypeptide binding]; other site 351745000862 putative GSH binding site (G-site) [chemical binding]; other site 351745000863 putative dimer interface [polypeptide binding]; other site 351745000864 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 351745000865 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 351745000866 potential catalytic triad [active] 351745000867 conserved cys residue [active] 351745000868 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 351745000869 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 351745000870 dimer interface [polypeptide binding]; other site 351745000871 active site 351745000872 metal binding site [ion binding]; metal-binding site 351745000873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 351745000874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 351745000875 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 351745000876 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745000877 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745000878 dimer interface [polypeptide binding]; other site 351745000879 putative CheW interface [polypeptide binding]; other site 351745000880 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 351745000881 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 351745000882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745000883 S-adenosylmethionine binding site [chemical binding]; other site 351745000884 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 351745000885 Transposase; Region: HTH_Tnp_1; cl17663 351745000886 Winged helix-turn helix; Region: HTH_29; pfam13551 351745000887 Homeodomain-like domain; Region: HTH_32; pfam13565 351745000888 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 351745000889 Integrase core domain; Region: rve; pfam00665 351745000890 Integrase core domain; Region: rve_3; pfam13683 351745000891 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 351745000892 substrate binding site [chemical binding]; other site 351745000893 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 351745000894 ATP binding site [chemical binding]; other site 351745000895 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745000896 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745000897 metal binding site [ion binding]; metal-binding site 351745000898 active site 351745000899 I-site; other site 351745000900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 351745000901 MOSC domain; Region: MOSC; pfam03473 351745000902 3-alpha domain; Region: 3-alpha; pfam03475 351745000903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 351745000904 Cache domain; Region: Cache_1; pfam02743 351745000905 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745000906 dimerization interface [polypeptide binding]; other site 351745000907 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745000908 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745000909 dimer interface [polypeptide binding]; other site 351745000910 putative CheW interface [polypeptide binding]; other site 351745000911 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 351745000912 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 351745000913 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 351745000914 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 351745000915 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 351745000916 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351745000917 FeS/SAM binding site; other site 351745000918 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 351745000919 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 351745000920 trimer interface [polypeptide binding]; other site 351745000921 dimer interface [polypeptide binding]; other site 351745000922 putative active site [active] 351745000923 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 351745000924 MoaE interaction surface [polypeptide binding]; other site 351745000925 MoeB interaction surface [polypeptide binding]; other site 351745000926 thiocarboxylated glycine; other site 351745000927 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 351745000928 MoaE homodimer interface [polypeptide binding]; other site 351745000929 MoaD interaction [polypeptide binding]; other site 351745000930 active site residues [active] 351745000931 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 351745000932 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 351745000933 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 351745000934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351745000935 dimer interface [polypeptide binding]; other site 351745000936 conserved gate region; other site 351745000937 putative PBP binding loops; other site 351745000938 ABC-ATPase subunit interface; other site 351745000939 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 351745000940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745000941 Walker A/P-loop; other site 351745000942 ATP binding site [chemical binding]; other site 351745000943 Q-loop/lid; other site 351745000944 ABC transporter signature motif; other site 351745000945 Walker B; other site 351745000946 D-loop; other site 351745000947 H-loop/switch region; other site 351745000948 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 351745000949 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 351745000950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745000951 active site 351745000952 phosphorylation site [posttranslational modification] 351745000953 intermolecular recognition site; other site 351745000954 dimerization interface [polypeptide binding]; other site 351745000955 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745000956 DNA binding site [nucleotide binding] 351745000957 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 351745000958 HAMP domain; Region: HAMP; pfam00672 351745000959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745000960 dimer interface [polypeptide binding]; other site 351745000961 phosphorylation site [posttranslational modification] 351745000962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745000963 ATP binding site [chemical binding]; other site 351745000964 Mg2+ binding site [ion binding]; other site 351745000965 G-X-G motif; other site 351745000966 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 351745000967 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 351745000968 active site 351745000969 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 351745000970 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 351745000971 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745000972 N-terminal plug; other site 351745000973 ligand-binding site [chemical binding]; other site 351745000974 Protein of unknown function (DUF2986); Region: DUF2986; pfam11661 351745000975 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 351745000976 Peptidase family M23; Region: Peptidase_M23; pfam01551 351745000977 CHAP domain; Region: CHAP; pfam05257 351745000978 Domain of unknown function (DUF1864); Region: DUF1864; pfam08933 351745000979 kynureninase; Region: kynureninase; TIGR01814 351745000980 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 351745000981 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 351745000982 catalytic residue [active] 351745000983 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00144 351745000984 glutamine synthetase; Provisional; Region: glnA; PRK09469 351745000985 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 351745000986 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 351745000987 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 351745000988 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 351745000989 G1 box; other site 351745000990 putative GEF interaction site [polypeptide binding]; other site 351745000991 GTP/Mg2+ binding site [chemical binding]; other site 351745000992 Switch I region; other site 351745000993 G2 box; other site 351745000994 G3 box; other site 351745000995 Switch II region; other site 351745000996 G4 box; other site 351745000997 G5 box; other site 351745000998 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 351745000999 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 351745001000 SnoaL-like domain; Region: SnoaL_3; pfam13474 351745001001 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745001002 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745001003 metal binding site [ion binding]; metal-binding site 351745001004 active site 351745001005 I-site; other site 351745001006 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 351745001007 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 351745001008 dimer interface [polypeptide binding]; other site 351745001009 active site 351745001010 heme binding site [chemical binding]; other site 351745001011 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 351745001012 4Fe-4S binding domain; Region: Fer4_5; pfam12801 351745001013 4Fe-4S binding domain; Region: Fer4_5; pfam12801 351745001014 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 351745001015 hypothetical protein; Reviewed; Region: PRK01637 351745001016 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 351745001017 putative active site [active] 351745001018 dimerization interface [polypeptide binding]; other site 351745001019 putative tRNAtyr binding site [nucleotide binding]; other site 351745001020 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 351745001021 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 351745001022 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 351745001023 azoreductase; Reviewed; Region: PRK00170 351745001024 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 351745001025 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 351745001026 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 351745001027 non-specific DNA binding site [nucleotide binding]; other site 351745001028 salt bridge; other site 351745001029 sequence-specific DNA binding site [nucleotide binding]; other site 351745001030 Cupin domain; Region: Cupin_2; pfam07883 351745001031 Benzoate membrane transport protein; Region: BenE; pfam03594 351745001032 benzoate transporter; Region: benE; TIGR00843 351745001033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745001034 Coenzyme A binding pocket [chemical binding]; other site 351745001035 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 351745001036 active site 351745001037 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 351745001038 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 351745001039 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 351745001040 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 351745001041 dimer interface [polypeptide binding]; other site 351745001042 active site 351745001043 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 351745001044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 351745001045 NAD(P) binding site [chemical binding]; other site 351745001046 active site 351745001047 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 351745001048 putative active site 1 [active] 351745001049 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 351745001050 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 351745001051 dimer interface [polypeptide binding]; other site 351745001052 active site 351745001053 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 351745001054 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 351745001055 Predicted exporter [General function prediction only]; Region: COG4258 351745001056 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 351745001057 active site 351745001058 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 351745001059 active sites [active] 351745001060 tetramer interface [polypeptide binding]; other site 351745001061 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 351745001062 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 351745001063 Ligand binding site; other site 351745001064 Putative Catalytic site; other site 351745001065 DXD motif; other site 351745001066 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 351745001067 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 351745001068 putative acyl-acceptor binding pocket; other site 351745001069 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 351745001070 active site 2 [active] 351745001071 active site 1 [active] 351745001072 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 351745001073 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 351745001074 acyl-activating enzyme (AAE) consensus motif; other site 351745001075 AMP binding site [chemical binding]; other site 351745001076 active site 351745001077 CoA binding site [chemical binding]; other site 351745001078 Predicted membrane protein [Function unknown]; Region: COG4648 351745001079 acyl carrier protein; Provisional; Region: PRK05350 351745001080 Phosphopantetheine attachment site; Region: PP-binding; cl09936 351745001081 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 351745001082 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 351745001083 putative acyl-acceptor binding pocket; other site 351745001084 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 351745001085 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 351745001086 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 351745001087 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 351745001088 generic binding surface II; other site 351745001089 ssDNA binding site; other site 351745001090 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351745001091 ATP binding site [chemical binding]; other site 351745001092 putative Mg++ binding site [ion binding]; other site 351745001093 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745001094 nucleotide binding region [chemical binding]; other site 351745001095 ATP-binding site [chemical binding]; other site 351745001096 inner membrane protein; Provisional; Region: PRK10995 351745001097 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 351745001098 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 351745001099 ligand binding site [chemical binding]; other site 351745001100 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 351745001101 HipA-like N-terminal domain; Region: HipA_N; pfam07805 351745001102 HipA-like C-terminal domain; Region: HipA_C; pfam07804 351745001103 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 351745001104 non-specific DNA binding site [nucleotide binding]; other site 351745001105 salt bridge; other site 351745001106 sequence-specific DNA binding site [nucleotide binding]; other site 351745001107 Transposase; Region: HTH_Tnp_1; pfam01527 351745001108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 351745001109 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 351745001110 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 351745001111 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 351745001112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 351745001113 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 351745001114 G1 box; other site 351745001115 GTP/Mg2+ binding site [chemical binding]; other site 351745001116 G2 box; other site 351745001117 Switch I region; other site 351745001118 G3 box; other site 351745001119 Switch II region; other site 351745001120 G4 box; other site 351745001121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745001122 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 351745001123 Walker A motif; other site 351745001124 ATP binding site [chemical binding]; other site 351745001125 Walker B motif; other site 351745001126 arginine finger; other site 351745001127 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 351745001128 HsdM N-terminal domain; Region: HsdM_N; pfam12161 351745001129 Methyltransferase domain; Region: Methyltransf_26; pfam13659 351745001130 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 351745001131 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 351745001132 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 351745001133 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 351745001134 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 351745001135 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 351745001136 Protein of unknown function DUF45; Region: DUF45; pfam01863 351745001137 HNH endonuclease; Region: HNH_2; pfam13391 351745001138 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 351745001139 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 351745001140 integrase; Provisional; Region: PRK09692 351745001141 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 351745001142 active site 351745001143 Int/Topo IB signature motif; other site 351745001144 hypothetical protein; Provisional; Region: PRK11820 351745001145 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 351745001146 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 351745001147 ribonuclease PH; Reviewed; Region: rph; PRK00173 351745001148 Ribonuclease PH; Region: RNase_PH_bact; cd11362 351745001149 hexamer interface [polypeptide binding]; other site 351745001150 active site 351745001151 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 351745001152 active site 351745001153 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 351745001154 GTP cyclohydrolase I; Provisional; Region: PLN03044 351745001155 active site 351745001156 division inhibitor protein; Provisional; Region: slmA; PRK09480 351745001157 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 351745001158 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 351745001159 trimer interface [polypeptide binding]; other site 351745001160 active site 351745001161 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 351745001162 Flavoprotein; Region: Flavoprotein; pfam02441 351745001163 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 351745001164 hypothetical protein; Reviewed; Region: PRK00024 351745001165 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 351745001166 MPN+ (JAMM) motif; other site 351745001167 Zinc-binding site [ion binding]; other site 351745001168 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 351745001169 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 351745001170 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 351745001171 active site 351745001172 catalytic residues [active] 351745001173 DNA binding site [nucleotide binding] 351745001174 Int/Topo IB signature motif; other site 351745001175 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 351745001176 active site 351745001177 catalytic residues [active] 351745001178 DNA binding site [nucleotide binding] 351745001179 Int/Topo IB signature motif; other site 351745001180 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 351745001181 hypothetical protein; Provisional; Region: PRK09272 351745001182 Penicillinase repressor; Region: Pencillinase_R; cl17580 351745001183 Peptidase family M48; Region: Peptidase_M48; cl12018 351745001184 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 351745001185 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 351745001186 E3 interaction surface; other site 351745001187 lipoyl attachment site [posttranslational modification]; other site 351745001188 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745001189 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 351745001190 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 351745001191 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 351745001192 putative DNA binding site [nucleotide binding]; other site 351745001193 putative Zn2+ binding site [ion binding]; other site 351745001194 Transposase; Region: HTH_Tnp_1; cl17663 351745001195 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 351745001196 HTH-like domain; Region: HTH_21; pfam13276 351745001197 Integrase core domain; Region: rve; pfam00665 351745001198 Integrase core domain; Region: rve; pfam00665 351745001199 Integrase core domain; Region: rve_3; pfam13683 351745001200 Predicted ATPase [General function prediction only]; Region: COG5293 351745001201 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 351745001202 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 351745001203 Transposase [DNA replication, recombination, and repair]; Region: COG5421 351745001204 N-acetylglutamate synthase; Validated; Region: PRK05279 351745001205 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 351745001206 putative feedback inhibition sensing region; other site 351745001207 putative nucleotide binding site [chemical binding]; other site 351745001208 putative substrate binding site [chemical binding]; other site 351745001209 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745001210 Coenzyme A binding pocket [chemical binding]; other site 351745001211 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 351745001212 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 351745001213 CoenzymeA binding site [chemical binding]; other site 351745001214 subunit interaction site [polypeptide binding]; other site 351745001215 PHB binding site; other site 351745001216 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 351745001217 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351745001218 ATP binding site [chemical binding]; other site 351745001219 putative Mg++ binding site [ion binding]; other site 351745001220 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745001221 nucleotide binding region [chemical binding]; other site 351745001222 ATP-binding site [chemical binding]; other site 351745001223 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 351745001224 HRDC domain; Region: HRDC; pfam00570 351745001225 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745001226 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745001227 active site 351745001228 I-site; other site 351745001229 metal binding site [ion binding]; metal-binding site 351745001230 2-isopropylmalate synthase; Validated; Region: PRK00915 351745001231 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 351745001232 active site 351745001233 catalytic residues [active] 351745001234 metal binding site [ion binding]; metal-binding site 351745001235 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 351745001236 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 351745001237 tartrate dehydrogenase; Region: TTC; TIGR02089 351745001238 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 351745001239 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 351745001240 substrate binding site [chemical binding]; other site 351745001241 ligand binding site [chemical binding]; other site 351745001242 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 351745001243 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 351745001244 substrate binding site [chemical binding]; other site 351745001245 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 351745001246 glycerol kinase; Provisional; Region: glpK; PRK00047 351745001247 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 351745001248 N- and C-terminal domain interface [polypeptide binding]; other site 351745001249 active site 351745001250 MgATP binding site [chemical binding]; other site 351745001251 catalytic site [active] 351745001252 metal binding site [ion binding]; metal-binding site 351745001253 glycerol binding site [chemical binding]; other site 351745001254 homotetramer interface [polypeptide binding]; other site 351745001255 homodimer interface [polypeptide binding]; other site 351745001256 FBP binding site [chemical binding]; other site 351745001257 protein IIAGlc interface [polypeptide binding]; other site 351745001258 cell division protein MraZ; Reviewed; Region: PRK00326 351745001259 MraZ protein; Region: MraZ; pfam02381 351745001260 MraZ protein; Region: MraZ; pfam02381 351745001261 MraW methylase family; Region: Methyltransf_5; pfam01795 351745001262 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 351745001263 Cell division protein FtsL; Region: FtsL; pfam04999 351745001264 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 351745001265 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 351745001266 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 351745001267 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 351745001268 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 351745001269 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 351745001270 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 351745001271 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 351745001272 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 351745001273 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 351745001274 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 351745001275 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 351745001276 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 351745001277 Mg++ binding site [ion binding]; other site 351745001278 putative catalytic motif [active] 351745001279 putative substrate binding site [chemical binding]; other site 351745001280 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 351745001281 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 351745001282 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 351745001283 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 351745001284 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 351745001285 active site 351745001286 homodimer interface [polypeptide binding]; other site 351745001287 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 351745001288 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 351745001289 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 351745001290 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 351745001291 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 351745001292 Cell division protein FtsQ; Region: FtsQ; pfam03799 351745001293 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 351745001294 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 351745001295 nucleotide binding site [chemical binding]; other site 351745001296 Cell division protein FtsA; Region: FtsA; pfam14450 351745001297 cell division protein FtsZ; Validated; Region: PRK09330 351745001298 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 351745001299 nucleotide binding site [chemical binding]; other site 351745001300 SulA interaction site; other site 351745001301 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 351745001302 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 351745001303 Protein of unknown function (DUF721); Region: DUF721; cl02324 351745001304 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 351745001305 Peptidase family M23; Region: Peptidase_M23; pfam01551 351745001306 preprotein translocase subunit SecA; Reviewed; Region: PRK13107 351745001307 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 351745001308 ATP binding site [chemical binding]; other site 351745001309 putative Mg++ binding site [ion binding]; other site 351745001310 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 351745001311 SEC-C motif; Region: SEC-C; pfam02810 351745001312 bile acid transporter; Region: bass; TIGR00841 351745001313 Sodium Bile acid symporter family; Region: SBF; pfam01758 351745001314 coproporphyrinogen III oxidase; Provisional; Region: PRK08629 351745001315 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351745001316 FeS/SAM binding site; other site 351745001317 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 351745001318 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 351745001319 enterobactin receptor protein; Provisional; Region: PRK13483 351745001320 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745001321 N-terminal plug; other site 351745001322 ligand-binding site [chemical binding]; other site 351745001323 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745001324 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745001325 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 351745001326 putative effector binding pocket; other site 351745001327 dimerization interface [polypeptide binding]; other site 351745001328 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 351745001329 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 351745001330 active site 351745001331 nucleophile elbow; other site 351745001332 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 351745001333 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745001334 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 351745001335 substrate binding pocket [chemical binding]; other site 351745001336 dimerization interface [polypeptide binding]; other site 351745001337 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 351745001338 EamA-like transporter family; Region: EamA; pfam00892 351745001339 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 351745001340 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 351745001341 Sulfate transporter family; Region: Sulfate_transp; pfam00916 351745001342 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 351745001343 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 351745001344 Ligand Binding Site [chemical binding]; other site 351745001345 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 351745001346 Ligand Binding Site [chemical binding]; other site 351745001347 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 351745001348 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 351745001349 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 351745001350 catalytic residues [active] 351745001351 catalytic nucleophile [active] 351745001352 Presynaptic Site I dimer interface [polypeptide binding]; other site 351745001353 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 351745001354 Synaptic Flat tetramer interface [polypeptide binding]; other site 351745001355 Synaptic Site I dimer interface [polypeptide binding]; other site 351745001356 DNA binding site [nucleotide binding] 351745001357 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 351745001358 DNA-binding interface [nucleotide binding]; DNA binding site 351745001359 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 351745001360 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 351745001361 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 351745001362 DNA binding residues [nucleotide binding] 351745001363 dimer interface [polypeptide binding]; other site 351745001364 putative metal binding site [ion binding]; other site 351745001365 Heavy-metal-associated domain; Region: HMA; pfam00403 351745001366 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 351745001367 lipoprotein signal peptidase; Provisional; Region: PRK14776 351745001368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 351745001369 Transposase; Region: DDE_Tnp_ISL3; pfam01610 351745001370 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 351745001371 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 351745001372 putative active site [active] 351745001373 metal binding site [ion binding]; metal-binding site 351745001374 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 351745001375 putative catalytic cysteine [active] 351745001376 Domain of unknown function (DUF336); Region: DUF336; cl01249 351745001377 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 351745001378 Hexamer/Pentamer interface [polypeptide binding]; other site 351745001379 central pore; other site 351745001380 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 351745001381 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 351745001382 Propanediol utilisation protein PduL; Region: PduL; pfam06130 351745001383 Propanediol utilisation protein PduL; Region: PduL; pfam06130 351745001384 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 351745001385 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 351745001386 putative hexamer interface [polypeptide binding]; other site 351745001387 putative hexagonal pore; other site 351745001388 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 351745001389 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 351745001390 Hexamer interface [polypeptide binding]; other site 351745001391 Hexagonal pore residue; other site 351745001392 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 351745001393 amphipathic channel; other site 351745001394 Asn-Pro-Ala signature motifs; other site 351745001395 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 351745001396 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 351745001397 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 351745001398 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 351745001399 dimer interface [polypeptide binding]; other site 351745001400 active site 351745001401 glycine loop; other site 351745001402 propanediol utilization protein PduB; Provisional; Region: PRK15415 351745001403 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 351745001404 putative hexamer interface [polypeptide binding]; other site 351745001405 putative hexagonal pore; other site 351745001406 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 351745001407 putative hexamer interface [polypeptide binding]; other site 351745001408 putative hexagonal pore; other site 351745001409 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 351745001410 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 351745001411 Hexamer interface [polypeptide binding]; other site 351745001412 Putative hexagonal pore residue; other site 351745001413 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 351745001414 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 351745001415 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 351745001416 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 351745001417 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 351745001418 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 351745001419 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 351745001420 active site 351745001421 DNA binding site [nucleotide binding] 351745001422 Int/Topo IB signature motif; other site 351745001423 Homeodomain-like domain; Region: HTH_23; pfam13384 351745001424 Winged helix-turn helix; Region: HTH_29; pfam13551 351745001425 Homeodomain-like domain; Region: HTH_32; pfam13565 351745001426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 351745001427 DDE superfamily endonuclease; Region: DDE_3; pfam13358 351745001428 Sensory domain found in PocR; Region: PocR; pfam10114 351745001429 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 351745001430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 351745001431 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 351745001432 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 351745001433 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 351745001434 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 351745001435 DNA binding residues [nucleotide binding] 351745001436 dimer interface [polypeptide binding]; other site 351745001437 putative metal binding site [ion binding]; other site 351745001438 Heavy-metal-associated domain; Region: HMA; pfam00403 351745001439 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 351745001440 lipoprotein signal peptidase; Provisional; Region: PRK14776 351745001441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 351745001442 Transposase; Region: DDE_Tnp_ISL3; pfam01610 351745001443 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 351745001444 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 351745001445 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 351745001446 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 351745001447 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 351745001448 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 351745001449 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 351745001450 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 351745001451 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 351745001452 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 351745001453 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 351745001454 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 351745001455 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 351745001456 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 351745001457 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 351745001458 ligand binding site [chemical binding]; other site 351745001459 flexible hinge region; other site 351745001460 Helix-turn-helix domain; Region: HTH_36; pfam13730 351745001461 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 351745001462 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 351745001463 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 351745001464 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 351745001465 Nucleoside recognition; Region: Gate; pfam07670 351745001466 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 351745001467 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 351745001468 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 351745001469 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 351745001470 FHIPEP family; Region: FHIPEP; pfam00771 351745001471 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 351745001472 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 351745001473 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 351745001474 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 351745001475 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 351745001476 flagellar motor switch protein FliN; Region: fliN; TIGR02480 351745001477 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 351745001478 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 351745001479 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 351745001480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745001481 Walker A motif; other site 351745001482 ATP binding site [chemical binding]; other site 351745001483 Walker B motif; other site 351745001484 arginine finger; other site 351745001485 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 351745001486 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 351745001487 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 351745001488 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 351745001489 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 351745001490 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 351745001491 FliG C-terminal domain; Region: FliG_C; pfam01706 351745001492 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 351745001493 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 351745001494 Flagellar assembly protein FliH; Region: FliH; pfam02108 351745001495 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 351745001496 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 351745001497 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 351745001498 Walker A motif; other site 351745001499 ATP binding site [chemical binding]; other site 351745001500 Walker B motif; other site 351745001501 FlgN protein; Region: FlgN; pfam05130 351745001502 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 351745001503 SAF-like; Region: SAF_2; pfam13144 351745001504 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 351745001505 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 351745001506 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 351745001507 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 351745001508 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 351745001509 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 351745001510 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 351745001511 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 351745001512 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 351745001513 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 351745001514 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 351745001515 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 351745001516 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 351745001517 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 351745001518 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 351745001519 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 351745001520 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 351745001521 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 351745001522 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 351745001523 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 351745001524 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 351745001525 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 351745001526 peptidoglycan hydrolase; Reviewed; Region: flgJ; PRK12708 351745001527 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 351745001528 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 351745001529 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 351745001530 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 351745001531 flagellin; Provisional; Region: PRK12802 351745001532 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 351745001533 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 351745001534 flagellin; Provisional; Region: PRK12802 351745001535 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 351745001536 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 351745001537 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 351745001538 flagellar capping protein; Reviewed; Region: fliD; PRK08032 351745001539 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 351745001540 Flagellar protein FliS; Region: FliS; cl00654 351745001541 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 351745001542 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 351745001543 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 351745001544 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 351745001545 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 351745001546 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 351745001547 DNA binding residues [nucleotide binding] 351745001548 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 351745001549 flagellar motor stator protein MotA; Region: MotA1; TIGR03818 351745001550 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 351745001551 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 351745001552 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 351745001553 ligand binding site [chemical binding]; other site 351745001554 PilZ domain; Region: PilZ; pfam07238 351745001555 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 351745001556 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 351745001557 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 351745001558 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 351745001559 FMN binding site [chemical binding]; other site 351745001560 active site 351745001561 catalytic residues [active] 351745001562 substrate binding site [chemical binding]; other site 351745001563 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 351745001564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 351745001565 S-adenosylmethionine binding site [chemical binding]; other site 351745001566 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13554 351745001567 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 351745001568 Iron-sulfur protein interface; other site 351745001569 proximal heme binding site [chemical binding]; other site 351745001570 distal heme binding site [chemical binding]; other site 351745001571 dimer interface [polypeptide binding]; other site 351745001572 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 351745001573 Iron-sulfur protein interface; other site 351745001574 proximal heme binding site [chemical binding]; other site 351745001575 distal heme binding site [chemical binding]; other site 351745001576 dimer interface [polypeptide binding]; other site 351745001577 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 351745001578 L-aspartate oxidase; Provisional; Region: PRK06175 351745001579 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 351745001580 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 351745001581 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 351745001582 Uncharacterized conserved protein [Function unknown]; Region: COG1359 351745001583 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 351745001584 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 351745001585 putative NAD(P) binding site [chemical binding]; other site 351745001586 dimer interface [polypeptide binding]; other site 351745001587 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745001588 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745001589 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 351745001590 putative effector binding pocket; other site 351745001591 dimerization interface [polypeptide binding]; other site 351745001592 transcription termination factor Rho; Provisional; Region: rho; PRK09376 351745001593 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 351745001594 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 351745001595 RNA binding site [nucleotide binding]; other site 351745001596 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 351745001597 multimer interface [polypeptide binding]; other site 351745001598 Walker A motif; other site 351745001599 ATP binding site [chemical binding]; other site 351745001600 Walker B motif; other site 351745001601 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 351745001602 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 351745001603 catalytic residues [active] 351745001604 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 351745001605 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 351745001606 ATP binding site [chemical binding]; other site 351745001607 Mg++ binding site [ion binding]; other site 351745001608 motif III; other site 351745001609 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745001610 nucleotide binding region [chemical binding]; other site 351745001611 ATP-binding site [chemical binding]; other site 351745001612 exopolyphosphatase; Region: exo_poly_only; TIGR03706 351745001613 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 351745001614 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 351745001615 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 351745001616 catalytic residues [active] 351745001617 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 351745001618 active site 351745001619 8-oxo-dGMP binding site [chemical binding]; other site 351745001620 nudix motif; other site 351745001621 metal binding site [ion binding]; metal-binding site 351745001622 Domain of unknown function (DUF329); Region: DUF329; pfam03884 351745001623 hypothetical protein; Provisional; Region: PRK05287 351745001624 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 351745001625 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 351745001626 CoA-binding site [chemical binding]; other site 351745001627 ATP-binding [chemical binding]; other site 351745001628 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 351745001629 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 351745001630 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 351745001631 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 351745001632 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 351745001633 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 351745001634 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 351745001635 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 351745001636 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 351745001637 Walker A motif; other site 351745001638 ATP binding site [chemical binding]; other site 351745001639 Walker B motif; other site 351745001640 putative major pilin subunit; Provisional; Region: PRK10574 351745001641 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 351745001642 Transposase; Region: DDE_Tnp_ISL3; pfam01610 351745001643 lipoprotein signal peptidase; Provisional; Region: PRK14776 351745001644 Heavy-metal-associated domain; Region: HMA; pfam00403 351745001645 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 351745001646 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 351745001647 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 351745001648 DNA binding residues [nucleotide binding] 351745001649 dimer interface [polypeptide binding]; other site 351745001650 putative metal binding site [ion binding]; other site 351745001651 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 351745001652 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 351745001653 dimerization interface [polypeptide binding]; other site 351745001654 active site 351745001655 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 351745001656 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 351745001657 amidase catalytic site [active] 351745001658 Zn binding residues [ion binding]; other site 351745001659 substrate binding site [chemical binding]; other site 351745001660 regulatory protein AmpE; Provisional; Region: PRK10987 351745001661 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 351745001662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 351745001663 DNA-binding site [nucleotide binding]; DNA binding site 351745001664 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 351745001665 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 351745001666 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 351745001667 dimer interface [polypeptide binding]; other site 351745001668 TPP-binding site [chemical binding]; other site 351745001669 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 351745001670 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 351745001671 E3 interaction surface; other site 351745001672 lipoyl attachment site [posttranslational modification]; other site 351745001673 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 351745001674 E3 interaction surface; other site 351745001675 lipoyl attachment site [posttranslational modification]; other site 351745001676 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 351745001677 E3 interaction surface; other site 351745001678 lipoyl attachment site [posttranslational modification]; other site 351745001679 e3 binding domain; Region: E3_binding; pfam02817 351745001680 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 351745001681 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 351745001682 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 351745001683 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 351745001684 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 351745001685 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 351745001686 PAS fold; Region: PAS_3; pfam08447 351745001687 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 351745001688 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745001689 PAS domain; Region: PAS_9; pfam13426 351745001690 putative active site [active] 351745001691 heme pocket [chemical binding]; other site 351745001692 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745001693 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745001694 metal binding site [ion binding]; metal-binding site 351745001695 active site 351745001696 I-site; other site 351745001697 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745001698 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 351745001699 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 351745001700 active site 351745001701 nucleophile elbow; other site 351745001702 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 351745001703 Surface antigen; Region: Bac_surface_Ag; pfam01103 351745001704 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 351745001705 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 351745001706 active site 351745001707 Zn binding site [ion binding]; other site 351745001708 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 351745001709 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 351745001710 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 351745001711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351745001712 motif II; other site 351745001713 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 351745001714 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 351745001715 substrate binding site [chemical binding]; other site 351745001716 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 351745001717 substrate binding site [chemical binding]; other site 351745001718 ligand binding site [chemical binding]; other site 351745001719 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 351745001720 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 351745001721 substrate binding site [chemical binding]; other site 351745001722 active site 351745001723 PAS fold; Region: PAS_4; pfam08448 351745001724 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745001725 putative active site [active] 351745001726 heme pocket [chemical binding]; other site 351745001727 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745001728 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745001729 metal binding site [ion binding]; metal-binding site 351745001730 active site 351745001731 I-site; other site 351745001732 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745001733 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 351745001734 short chain dehydrogenase; Provisional; Region: PRK06181 351745001735 NADP binding site [chemical binding]; other site 351745001736 homodimer interface [polypeptide binding]; other site 351745001737 substrate binding site [chemical binding]; other site 351745001738 active site 351745001739 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 351745001740 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 351745001741 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 351745001742 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 351745001743 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 351745001744 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 351745001745 purine monophosphate binding site [chemical binding]; other site 351745001746 dimer interface [polypeptide binding]; other site 351745001747 putative catalytic residues [active] 351745001748 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 351745001749 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 351745001750 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 351745001751 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 351745001752 DNA binding residues [nucleotide binding] 351745001753 dimer interface [polypeptide binding]; other site 351745001754 metal binding site [ion binding]; metal-binding site 351745001755 Predicted permease; Region: DUF318; cl17795 351745001756 Predicted permease; Region: DUF318; cl17795 351745001757 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 351745001758 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 351745001759 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 351745001760 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 351745001761 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 351745001762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 351745001763 putative substrate translocation pore; other site 351745001764 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 351745001765 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 351745001766 transmembrane helices; other site 351745001767 thioredoxin 2; Provisional; Region: PRK10996 351745001768 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 351745001769 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 351745001770 catalytic residues [active] 351745001771 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 351745001772 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745001773 putative active site [active] 351745001774 PAS fold; Region: PAS_3; pfam08447 351745001775 heme pocket [chemical binding]; other site 351745001776 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745001777 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745001778 metal binding site [ion binding]; metal-binding site 351745001779 active site 351745001780 I-site; other site 351745001781 chaperone protein DnaJ; Provisional; Region: PRK14280 351745001782 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 351745001783 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 351745001784 Tannase and feruloyl esterase; Region: Tannase; pfam07519 351745001785 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 351745001786 outer membrane porin, OprD family; Region: OprD; pfam03573 351745001787 Transcriptional regulators [Transcription]; Region: FadR; COG2186 351745001788 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 351745001789 DNA-binding site [nucleotide binding]; DNA binding site 351745001790 FCD domain; Region: FCD; pfam07729 351745001791 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 351745001792 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 351745001793 DctM-like transporters; Region: DctM; pfam06808 351745001794 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 351745001795 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 351745001796 substrate binding pocket [chemical binding]; other site 351745001797 membrane-bound complex binding site; other site 351745001798 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 351745001799 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 351745001800 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 351745001801 nudix motif; other site 351745001802 Methyltransferase domain; Region: Methyltransf_31; pfam13847 351745001803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745001804 S-adenosylmethionine binding site [chemical binding]; other site 351745001805 Transglycosylase; Region: Transgly; pfam00912 351745001806 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 351745001807 Part of AAA domain; Region: AAA_19; pfam13245 351745001808 Family description; Region: UvrD_C_2; pfam13538 351745001809 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 351745001810 UbiA prenyltransferase family; Region: UbiA; pfam01040 351745001811 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 351745001812 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 351745001813 FMN binding site [chemical binding]; other site 351745001814 substrate binding site [chemical binding]; other site 351745001815 putative catalytic residue [active] 351745001816 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 351745001817 Pathogenicity locus; Region: Cdd1; pfam11731 351745001818 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 351745001819 metal binding site [ion binding]; metal-binding site 351745001820 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 351745001821 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 351745001822 catalytic residues [active] 351745001823 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 351745001824 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 351745001825 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 351745001826 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 351745001827 active site residue [active] 351745001828 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 351745001829 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 351745001830 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 351745001831 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 351745001832 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 351745001833 TPR motif; other site 351745001834 binding surface 351745001835 NosL; Region: NosL; pfam05573 351745001836 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 351745001837 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 351745001838 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 351745001839 Walker A/P-loop; other site 351745001840 ATP binding site [chemical binding]; other site 351745001841 Q-loop/lid; other site 351745001842 ABC transporter signature motif; other site 351745001843 Walker B; other site 351745001844 D-loop; other site 351745001845 H-loop/switch region; other site 351745001846 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 351745001847 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 351745001848 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745001849 DNA binding site [nucleotide binding] 351745001850 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 351745001851 FMN reductase; Validated; Region: fre; PRK08051 351745001852 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 351745001853 FAD binding pocket [chemical binding]; other site 351745001854 FAD binding motif [chemical binding]; other site 351745001855 phosphate binding motif [ion binding]; other site 351745001856 beta-alpha-beta structure motif; other site 351745001857 NAD binding pocket [chemical binding]; other site 351745001858 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 351745001859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 351745001860 NAD(P) binding site [chemical binding]; other site 351745001861 active site 351745001862 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 351745001863 Dehydroquinase class II; Region: DHquinase_II; pfam01220 351745001864 active site 351745001865 trimer interface [polypeptide binding]; other site 351745001866 dimer interface [polypeptide binding]; other site 351745001867 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 351745001868 hypothetical protein; Provisional; Region: PRK09256 351745001869 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 351745001870 Protein of unknown function (DUF3012); Region: DUF3012; pfam11216 351745001871 Outer membrane efflux protein; Region: OEP; pfam02321 351745001872 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 351745001873 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 351745001874 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745001875 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 351745001876 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 351745001877 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 351745001878 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 351745001879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745001880 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 351745001881 Coenzyme A binding pocket [chemical binding]; other site 351745001882 Uncharacterized conserved protein [Function unknown]; Region: COG1359 351745001883 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 351745001884 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 351745001885 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 351745001886 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 351745001887 Beta-Casp domain; Region: Beta-Casp; smart01027 351745001888 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 351745001889 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 351745001890 amino acid carrier protein; Region: agcS; TIGR00835 351745001891 conserved hypothetical protein; Region: QEGLA; TIGR02421 351745001892 CHASE domain; Region: CHASE; pfam03924 351745001893 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 351745001894 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745001895 putative active site [active] 351745001896 heme pocket [chemical binding]; other site 351745001897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745001898 dimer interface [polypeptide binding]; other site 351745001899 phosphorylation site [posttranslational modification] 351745001900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745001901 ATP binding site [chemical binding]; other site 351745001902 Mg2+ binding site [ion binding]; other site 351745001903 G-X-G motif; other site 351745001904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745001905 Response regulator receiver domain; Region: Response_reg; pfam00072 351745001906 active site 351745001907 phosphorylation site [posttranslational modification] 351745001908 intermolecular recognition site; other site 351745001909 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 351745001910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745001911 active site 351745001912 phosphorylation site [posttranslational modification] 351745001913 intermolecular recognition site; other site 351745001914 dimerization interface [polypeptide binding]; other site 351745001915 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745001916 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745001917 metal binding site [ion binding]; metal-binding site 351745001918 active site 351745001919 I-site; other site 351745001920 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745001921 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 351745001922 ATP-grasp domain; Region: ATP-grasp_4; cl17255 351745001923 conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001 351745001924 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 351745001925 IHF dimer interface [polypeptide binding]; other site 351745001926 IHF - DNA interface [nucleotide binding]; other site 351745001927 Response regulator receiver domain; Region: Response_reg; pfam00072 351745001928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745001929 active site 351745001930 phosphorylation site [posttranslational modification] 351745001931 intermolecular recognition site; other site 351745001932 dimerization interface [polypeptide binding]; other site 351745001933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745001934 Response regulator receiver domain; Region: Response_reg; pfam00072 351745001935 active site 351745001936 phosphorylation site [posttranslational modification] 351745001937 intermolecular recognition site; other site 351745001938 dimerization interface [polypeptide binding]; other site 351745001939 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 351745001940 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 351745001941 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745001942 FOG: CBS domain [General function prediction only]; Region: COG0517 351745001943 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 351745001944 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745001945 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745001946 metal binding site [ion binding]; metal-binding site 351745001947 active site 351745001948 I-site; other site 351745001949 TraB family; Region: TraB; pfam01963 351745001950 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 351745001951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745001952 S-adenosylmethionine binding site [chemical binding]; other site 351745001953 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 351745001954 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 351745001955 active site 2 [active] 351745001956 active site 1 [active] 351745001957 formate--tetrahydrofolate ligase; Provisional; Region: PRK13506 351745001958 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 351745001959 Potassium binding sites [ion binding]; other site 351745001960 Cesium cation binding sites [ion binding]; other site 351745001961 Periplasmic binding protein TroA_c. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_c; cd01145 351745001962 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 351745001963 putative ligand binding site [chemical binding]; other site 351745001964 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 351745001965 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 351745001966 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 351745001967 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 351745001968 putative acyl-acceptor binding pocket; other site 351745001969 RNase E inhibitor protein; Provisional; Region: PRK11191 351745001970 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 351745001971 PAS domain; Region: PAS_9; pfam13426 351745001972 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745001973 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745001974 metal binding site [ion binding]; metal-binding site 351745001975 active site 351745001976 I-site; other site 351745001977 Response regulator receiver domain; Region: Response_reg; pfam00072 351745001978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745001979 active site 351745001980 phosphorylation site [posttranslational modification] 351745001981 intermolecular recognition site; other site 351745001982 dimerization interface [polypeptide binding]; other site 351745001983 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 351745001984 enoyl-CoA hydratase; Provisional; Region: PRK07509 351745001985 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 351745001986 substrate binding site [chemical binding]; other site 351745001987 oxyanion hole (OAH) forming residues; other site 351745001988 trimer interface [polypeptide binding]; other site 351745001989 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 351745001990 ATP-dependent helicase HepA; Validated; Region: PRK04914 351745001991 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351745001992 ATP binding site [chemical binding]; other site 351745001993 putative Mg++ binding site [ion binding]; other site 351745001994 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745001995 nucleotide binding region [chemical binding]; other site 351745001996 ATP-binding site [chemical binding]; other site 351745001997 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 351745001998 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 351745001999 putative active site [active] 351745002000 PhoH-like protein; Region: PhoH; pfam02562 351745002001 Cache domain; Region: Cache_1; pfam02743 351745002002 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745002003 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 351745002004 putative active site [active] 351745002005 heme pocket [chemical binding]; other site 351745002006 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745002007 putative active site [active] 351745002008 heme pocket [chemical binding]; other site 351745002009 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745002010 dimer interface [polypeptide binding]; other site 351745002011 phosphorylation site [posttranslational modification] 351745002012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745002013 ATP binding site [chemical binding]; other site 351745002014 Mg2+ binding site [ion binding]; other site 351745002015 G-X-G motif; other site 351745002016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745002017 Response regulator receiver domain; Region: Response_reg; pfam00072 351745002018 active site 351745002019 phosphorylation site [posttranslational modification] 351745002020 intermolecular recognition site; other site 351745002021 dimerization interface [polypeptide binding]; other site 351745002022 Response regulator receiver domain; Region: Response_reg; pfam00072 351745002023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745002024 active site 351745002025 phosphorylation site [posttranslational modification] 351745002026 intermolecular recognition site; other site 351745002027 dimerization interface [polypeptide binding]; other site 351745002028 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 351745002029 active site 351745002030 Protein kinase domain; Region: Pkinase; pfam00069 351745002031 Catalytic domain of Protein Kinases; Region: PKc; cd00180 351745002032 active site 351745002033 ATP binding site [chemical binding]; other site 351745002034 substrate binding site [chemical binding]; other site 351745002035 activation loop (A-loop); other site 351745002036 dihydroorotase; Provisional; Region: PRK01211 351745002037 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 351745002038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745002039 S-adenosylmethionine binding site [chemical binding]; other site 351745002040 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 351745002041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745002042 PAS fold; Region: PAS_3; pfam08447 351745002043 putative active site [active] 351745002044 heme pocket [chemical binding]; other site 351745002045 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745002046 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745002047 dimer interface [polypeptide binding]; other site 351745002048 putative CheW interface [polypeptide binding]; other site 351745002049 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 351745002050 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 351745002051 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 351745002052 active site 351745002053 catalytic site [active] 351745002054 putative mechanosensitive channel protein; Provisional; Region: PRK10929 351745002055 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 351745002056 Mechanosensitive ion channel; Region: MS_channel; pfam00924 351745002057 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 351745002058 EamA-like transporter family; Region: EamA; pfam00892 351745002059 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 351745002060 GTPase RsgA; Reviewed; Region: PRK12288 351745002061 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 351745002062 RNA binding site [nucleotide binding]; other site 351745002063 homodimer interface [polypeptide binding]; other site 351745002064 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 351745002065 GTPase/Zn-binding domain interface [polypeptide binding]; other site 351745002066 GTP/Mg2+ binding site [chemical binding]; other site 351745002067 G4 box; other site 351745002068 G5 box; other site 351745002069 G1 box; other site 351745002070 Switch I region; other site 351745002071 G2 box; other site 351745002072 G3 box; other site 351745002073 Switch II region; other site 351745002074 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 351745002075 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 351745002076 catalytic site [active] 351745002077 putative active site [active] 351745002078 putative substrate binding site [chemical binding]; other site 351745002079 dimer interface [polypeptide binding]; other site 351745002080 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 351745002081 dinuclear metal binding motif [ion binding]; other site 351745002082 putative carbohydrate kinase; Provisional; Region: PRK10565 351745002083 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 351745002084 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 351745002085 putative substrate binding site [chemical binding]; other site 351745002086 putative ATP binding site [chemical binding]; other site 351745002087 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 351745002088 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 351745002089 AMIN domain; Region: AMIN; pfam11741 351745002090 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 351745002091 active site 351745002092 metal binding site [ion binding]; metal-binding site 351745002093 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 351745002094 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 351745002095 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 351745002096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745002097 ATP binding site [chemical binding]; other site 351745002098 Mg2+ binding site [ion binding]; other site 351745002099 G-X-G motif; other site 351745002100 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 351745002101 ATP binding site [chemical binding]; other site 351745002102 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 351745002103 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 351745002104 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 351745002105 bacterial Hfq-like; Region: Hfq; cd01716 351745002106 hexamer interface [polypeptide binding]; other site 351745002107 Sm1 motif; other site 351745002108 RNA binding site [nucleotide binding]; other site 351745002109 Sm2 motif; other site 351745002110 GTPase HflX; Provisional; Region: PRK11058 351745002111 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 351745002112 HflX GTPase family; Region: HflX; cd01878 351745002113 G1 box; other site 351745002114 GTP/Mg2+ binding site [chemical binding]; other site 351745002115 Switch I region; other site 351745002116 G2 box; other site 351745002117 G3 box; other site 351745002118 Switch II region; other site 351745002119 G4 box; other site 351745002120 G5 box; other site 351745002121 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 351745002122 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 351745002123 HflK protein; Region: hflK; TIGR01933 351745002124 HflC protein; Region: hflC; TIGR01932 351745002125 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 351745002126 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 351745002127 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 351745002128 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 351745002129 [2Fe-2S] cluster binding site [ion binding]; other site 351745002130 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 351745002131 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 351745002132 Qi binding site; other site 351745002133 intrachain domain interface; other site 351745002134 interchain domain interface [polypeptide binding]; other site 351745002135 heme bH binding site [chemical binding]; other site 351745002136 heme bL binding site [chemical binding]; other site 351745002137 Qo binding site; other site 351745002138 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 351745002139 interchain domain interface [polypeptide binding]; other site 351745002140 intrachain domain interface; other site 351745002141 Qi binding site; other site 351745002142 Qo binding site; other site 351745002143 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 351745002144 stringent starvation protein A; Provisional; Region: sspA; PRK09481 351745002145 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 351745002146 C-terminal domain interface [polypeptide binding]; other site 351745002147 putative GSH binding site (G-site) [chemical binding]; other site 351745002148 dimer interface [polypeptide binding]; other site 351745002149 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 351745002150 dimer interface [polypeptide binding]; other site 351745002151 N-terminal domain interface [polypeptide binding]; other site 351745002152 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 351745002153 Response regulator receiver domain; Region: Response_reg; pfam00072 351745002154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745002155 active site 351745002156 phosphorylation site [posttranslational modification] 351745002157 intermolecular recognition site; other site 351745002158 dimerization interface [polypeptide binding]; other site 351745002159 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 351745002160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 351745002161 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745002162 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745002163 metal binding site [ion binding]; metal-binding site 351745002164 active site 351745002165 I-site; other site 351745002166 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 351745002167 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 351745002168 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 351745002169 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 351745002170 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 351745002171 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 351745002172 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 351745002173 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 351745002174 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 351745002175 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 351745002176 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745002177 Coenzyme A binding pocket [chemical binding]; other site 351745002178 Part of AAA domain; Region: AAA_19; pfam13245 351745002179 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 351745002180 AAA domain; Region: AAA_12; pfam13087 351745002181 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 351745002182 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 351745002183 N-acetyl-D-glucosamine binding site [chemical binding]; other site 351745002184 catalytic residue [active] 351745002185 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 351745002186 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 351745002187 Leucine rich repeat; Region: LRR_8; pfam13855 351745002188 Leucine rich repeat; Region: LRR_8; pfam13855 351745002189 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 351745002190 active site 351745002191 ATP binding site [chemical binding]; other site 351745002192 substrate binding site [chemical binding]; other site 351745002193 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 351745002194 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745002195 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 351745002196 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 351745002197 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 351745002198 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 351745002199 NAD(P) binding site [chemical binding]; other site 351745002200 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 351745002201 active site 351745002202 catalytic residues [active] 351745002203 galactokinase; Provisional; Region: PRK05101 351745002204 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 351745002205 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 351745002206 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 351745002207 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 351745002208 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 351745002209 TrkA-N domain; Region: TrkA_N; pfam02254 351745002210 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 351745002211 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 351745002212 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 351745002213 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 351745002214 DsbD alpha interface [polypeptide binding]; other site 351745002215 catalytic residues [active] 351745002216 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 351745002217 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 351745002218 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 351745002219 heme-binding site [chemical binding]; other site 351745002220 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745002221 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745002222 metal binding site [ion binding]; metal-binding site 351745002223 active site 351745002224 I-site; other site 351745002225 Protein of unknown function (DUF2999); Region: DUF2999; pfam11212 351745002226 Isochorismatase family; Region: Isochorismatase; pfam00857 351745002227 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 351745002228 catalytic triad [active] 351745002229 dimer interface [polypeptide binding]; other site 351745002230 conserved cis-peptide bond; other site 351745002231 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 351745002232 Nitrogen regulatory protein P-II; Region: P-II; smart00938 351745002233 probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644 351745002234 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 351745002235 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 351745002236 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 351745002237 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 351745002238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745002239 Walker A/P-loop; other site 351745002240 ATP binding site [chemical binding]; other site 351745002241 Q-loop/lid; other site 351745002242 ABC transporter signature motif; other site 351745002243 Walker B; other site 351745002244 D-loop; other site 351745002245 H-loop/switch region; other site 351745002246 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 351745002247 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 351745002248 active site 351745002249 FMN binding site [chemical binding]; other site 351745002250 substrate binding site [chemical binding]; other site 351745002251 3Fe-4S cluster binding site [ion binding]; other site 351745002252 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 351745002253 catalytic core [active] 351745002254 ferredoxin-NADP reductase; Provisional; Region: PRK10926 351745002255 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 351745002256 FAD binding pocket [chemical binding]; other site 351745002257 FAD binding motif [chemical binding]; other site 351745002258 phosphate binding motif [ion binding]; other site 351745002259 beta-alpha-beta structure motif; other site 351745002260 NAD binding pocket [chemical binding]; other site 351745002261 putative glutathione S-transferase; Provisional; Region: PRK10357 351745002262 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 351745002263 putative C-terminal domain interface [polypeptide binding]; other site 351745002264 putative GSH binding site (G-site) [chemical binding]; other site 351745002265 putative dimer interface [polypeptide binding]; other site 351745002266 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 351745002267 substrate binding pocket (H-site) [chemical binding]; other site 351745002268 N-terminal domain interface [polypeptide binding]; other site 351745002269 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 351745002270 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 351745002271 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 351745002272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351745002273 dimer interface [polypeptide binding]; other site 351745002274 conserved gate region; other site 351745002275 putative PBP binding loops; other site 351745002276 ABC-ATPase subunit interface; other site 351745002277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351745002278 dimer interface [polypeptide binding]; other site 351745002279 conserved gate region; other site 351745002280 putative PBP binding loops; other site 351745002281 ABC-ATPase subunit interface; other site 351745002282 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 351745002283 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 351745002284 Walker A/P-loop; other site 351745002285 ATP binding site [chemical binding]; other site 351745002286 Q-loop/lid; other site 351745002287 ABC transporter signature motif; other site 351745002288 Walker B; other site 351745002289 D-loop; other site 351745002290 H-loop/switch region; other site 351745002291 TOBE domain; Region: TOBE_2; pfam08402 351745002292 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 351745002293 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 351745002294 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 351745002295 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745002296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745002297 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 351745002298 putative effector binding pocket; other site 351745002299 dimerization interface [polypeptide binding]; other site 351745002300 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 351745002301 NADH(P)-binding; Region: NAD_binding_10; pfam13460 351745002302 NAD binding site [chemical binding]; other site 351745002303 substrate binding site [chemical binding]; other site 351745002304 putative active site [active] 351745002305 arginine repressor; Provisional; Region: PRK05066 351745002306 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 351745002307 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 351745002308 malate dehydrogenase; Provisional; Region: PRK05086 351745002309 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 351745002310 NAD binding site [chemical binding]; other site 351745002311 dimerization interface [polypeptide binding]; other site 351745002312 Substrate binding site [chemical binding]; other site 351745002313 Protein of unknown function, DUF393; Region: DUF393; pfam04134 351745002314 dihydromonapterin reductase; Provisional; Region: PRK06483 351745002315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 351745002316 NAD(P) binding site [chemical binding]; other site 351745002317 active site 351745002318 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 351745002319 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 351745002320 Cell division protein ZapA; Region: ZapA; pfam05164 351745002321 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 351745002322 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 351745002323 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 351745002324 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 351745002325 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 351745002326 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 351745002327 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 351745002328 glycine cleavage system protein H; Provisional; Region: PRK13380 351745002329 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 351745002330 lipoyl attachment site [posttranslational modification]; other site 351745002331 glycine dehydrogenase; Provisional; Region: PRK05367 351745002332 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 351745002333 tetramer interface [polypeptide binding]; other site 351745002334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745002335 catalytic residue [active] 351745002336 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 351745002337 tetramer interface [polypeptide binding]; other site 351745002338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745002339 catalytic residue [active] 351745002340 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 351745002341 Transposase [DNA replication, recombination, and repair]; Region: COG5421 351745002342 Part of AAA domain; Region: AAA_19; pfam13245 351745002343 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 351745002344 AAA ATPase domain; Region: AAA_15; pfam13175 351745002345 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 351745002346 putative active site [active] 351745002347 putative metal-binding site [ion binding]; other site 351745002348 Nuclease-related domain; Region: NERD; pfam08378 351745002349 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 351745002350 Ribosome recycling factor; Region: RRF_GI; pfam12614 351745002351 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 351745002352 Transposase [DNA replication, recombination, and repair]; Region: COG5421 351745002353 Cache domain; Region: Cache_2; pfam08269 351745002354 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745002355 dimerization interface [polypeptide binding]; other site 351745002356 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745002357 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745002358 dimer interface [polypeptide binding]; other site 351745002359 putative CheW interface [polypeptide binding]; other site 351745002360 YcaO domain protein; Region: TIGR03549 351745002361 OsmC-like protein; Region: OsmC; pfam02566 351745002362 YcaO-like family; Region: YcaO; pfam02624 351745002363 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 351745002364 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 351745002365 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 351745002366 Soluble P-type ATPase [General function prediction only]; Region: COG4087 351745002367 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 351745002368 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 351745002369 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 351745002370 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745002371 N-terminal plug; other site 351745002372 ligand-binding site [chemical binding]; other site 351745002373 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 351745002374 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 351745002375 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 351745002376 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 351745002377 substrate binding pocket [chemical binding]; other site 351745002378 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 351745002379 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 351745002380 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 351745002381 FOG: CBS domain [General function prediction only]; Region: COG0517 351745002382 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 351745002383 PhoD-like phosphatase; Region: PhoD; pfam09423 351745002384 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 351745002385 putative active site [active] 351745002386 putative metal binding site [ion binding]; other site 351745002387 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 351745002388 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 351745002389 active site 351745002390 Protein of unknown function (DUF3622); Region: DUF3622; pfam12286 351745002391 Protein of unknown function (DUF3103); Region: DUF3103; pfam11301 351745002392 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 351745002393 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 351745002394 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 351745002395 substrate binding site [chemical binding]; other site 351745002396 dimer interface [polypeptide binding]; other site 351745002397 ATP binding site [chemical binding]; other site 351745002398 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 351745002399 active site 351745002400 tetramer interface [polypeptide binding]; other site 351745002401 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 351745002402 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 351745002403 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745002404 N-terminal plug; other site 351745002405 ligand-binding site [chemical binding]; other site 351745002406 HDOD domain; Region: HDOD; pfam08668 351745002407 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745002408 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745002409 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 351745002410 putative dimerization interface [polypeptide binding]; other site 351745002411 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 351745002412 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 351745002413 THF binding site; other site 351745002414 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 351745002415 substrate binding site [chemical binding]; other site 351745002416 THF binding site; other site 351745002417 zinc-binding site [ion binding]; other site 351745002418 macrolide transporter subunit MacA; Provisional; Region: PRK11578 351745002419 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 351745002420 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745002421 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 351745002422 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 351745002423 Walker A/P-loop; other site 351745002424 ATP binding site [chemical binding]; other site 351745002425 Q-loop/lid; other site 351745002426 ABC transporter signature motif; other site 351745002427 Walker B; other site 351745002428 D-loop; other site 351745002429 H-loop/switch region; other site 351745002430 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 351745002431 FtsX-like permease family; Region: FtsX; pfam02687 351745002432 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 351745002433 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745002434 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745002435 metal binding site [ion binding]; metal-binding site 351745002436 active site 351745002437 I-site; other site 351745002438 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 351745002439 Peptidase family M50; Region: Peptidase_M50; pfam02163 351745002440 active site 351745002441 putative substrate binding region [chemical binding]; other site 351745002442 protein structure with unknown function; Region: DUF4144; pfam13642 351745002443 Protein of unknown function (DUF342); Region: DUF342; pfam03961 351745002444 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 351745002445 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 351745002446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745002447 S-adenosylmethionine binding site [chemical binding]; other site 351745002448 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 351745002449 dimer interface [polypeptide binding]; other site 351745002450 Alkaline phosphatase homologues; Region: alkPPc; smart00098 351745002451 active site 351745002452 glutathione synthetase; Provisional; Region: PRK05246 351745002453 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 351745002454 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 351745002455 RNA methyltransferase, RsmE family; Region: TIGR00046 351745002456 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 351745002457 DNA-specific endonuclease I; Provisional; Region: PRK15137 351745002458 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 351745002459 hypothetical protein; Provisional; Region: PRK04860 351745002460 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 351745002461 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 351745002462 putative substrate binding pocket [chemical binding]; other site 351745002463 AC domain interface; other site 351745002464 catalytic triad [active] 351745002465 AB domain interface; other site 351745002466 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 351745002467 LysR family transcriptional regulator; Provisional; Region: PRK14997 351745002468 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745002469 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 351745002470 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 351745002471 putative effector binding pocket; other site 351745002472 dimerization interface [polypeptide binding]; other site 351745002473 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 351745002474 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 351745002475 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 351745002476 ATP-grasp domain; Region: ATP-grasp_4; cl17255 351745002477 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 351745002478 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 351745002479 carboxyltransferase (CT) interaction site; other site 351745002480 biotinylation site [posttranslational modification]; other site 351745002481 elongation factor G; Reviewed; Region: PRK00007 351745002482 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 351745002483 G1 box; other site 351745002484 putative GEF interaction site [polypeptide binding]; other site 351745002485 GTP/Mg2+ binding site [chemical binding]; other site 351745002486 Switch I region; other site 351745002487 G2 box; other site 351745002488 G3 box; other site 351745002489 Switch II region; other site 351745002490 G4 box; other site 351745002491 G5 box; other site 351745002492 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 351745002493 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 351745002494 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 351745002495 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745002496 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745002497 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 351745002498 putative dimerization interface [polypeptide binding]; other site 351745002499 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 351745002500 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 351745002501 4Fe-4S binding domain; Region: Fer4_5; pfam12801 351745002502 4Fe-4S binding domain; Region: Fer4_5; pfam12801 351745002503 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 351745002504 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 351745002505 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 351745002506 [4Fe-4S] binding site [ion binding]; other site 351745002507 molybdopterin cofactor binding site; other site 351745002508 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 351745002509 molybdopterin cofactor binding site; other site 351745002510 NapD protein; Region: NapD; pfam03927 351745002511 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 351745002512 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 351745002513 FtsX-like permease family; Region: FtsX; pfam02687 351745002514 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 351745002515 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 351745002516 Walker A/P-loop; other site 351745002517 ATP binding site [chemical binding]; other site 351745002518 Q-loop/lid; other site 351745002519 ABC transporter signature motif; other site 351745002520 Walker B; other site 351745002521 D-loop; other site 351745002522 H-loop/switch region; other site 351745002523 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 351745002524 amino acid carrier protein; Region: agcS; TIGR00835 351745002525 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 351745002526 PAS domain; Region: PAS_9; pfam13426 351745002527 PAS domain S-box; Region: sensory_box; TIGR00229 351745002528 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745002529 putative active site [active] 351745002530 heme pocket [chemical binding]; other site 351745002531 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745002532 PAS fold; Region: PAS_3; pfam08447 351745002533 putative active site [active] 351745002534 heme pocket [chemical binding]; other site 351745002535 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745002536 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 351745002537 putative active site [active] 351745002538 heme pocket [chemical binding]; other site 351745002539 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745002540 putative active site [active] 351745002541 heme pocket [chemical binding]; other site 351745002542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 351745002543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745002544 dimer interface [polypeptide binding]; other site 351745002545 phosphorylation site [posttranslational modification] 351745002546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745002547 ATP binding site [chemical binding]; other site 351745002548 Mg2+ binding site [ion binding]; other site 351745002549 G-X-G motif; other site 351745002550 Response regulator receiver domain; Region: Response_reg; pfam00072 351745002551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745002552 active site 351745002553 phosphorylation site [posttranslational modification] 351745002554 intermolecular recognition site; other site 351745002555 dimerization interface [polypeptide binding]; other site 351745002556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745002557 Response regulator receiver domain; Region: Response_reg; pfam00072 351745002558 active site 351745002559 phosphorylation site [posttranslational modification] 351745002560 intermolecular recognition site; other site 351745002561 dimerization interface [polypeptide binding]; other site 351745002562 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 351745002563 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 351745002564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745002565 active site 351745002566 phosphorylation site [posttranslational modification] 351745002567 intermolecular recognition site; other site 351745002568 dimerization interface [polypeptide binding]; other site 351745002569 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 351745002570 Zn2+ binding site [ion binding]; other site 351745002571 Mg2+ binding site [ion binding]; other site 351745002572 putative global regulator; Reviewed; Region: PRK09559 351745002573 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 351745002574 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 351745002575 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 351745002576 ligand binding site [chemical binding]; other site 351745002577 NAD binding site [chemical binding]; other site 351745002578 tetramer interface [polypeptide binding]; other site 351745002579 catalytic site [active] 351745002580 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 351745002581 L-serine binding site [chemical binding]; other site 351745002582 ACT domain interface; other site 351745002583 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 351745002584 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 351745002585 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 351745002586 DNA binding residues [nucleotide binding] 351745002587 dimerization interface [polypeptide binding]; other site 351745002588 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 351745002589 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 351745002590 major curlin subunit; Provisional; Region: csgA; PRK10051 351745002591 Curlin associated repeat; Region: Curlin_rpt; pfam07012 351745002592 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 351745002593 Curlin associated repeat; Region: Curlin_rpt; pfam07012 351745002594 Curlin associated repeat; Region: Curlin_rpt; pfam07012 351745002595 Curlin associated repeat; Region: Curlin_rpt; pfam07012 351745002596 Pantoate-beta-alanine ligase; Region: PanC; cd00560 351745002597 pantoate--beta-alanine ligase; Region: panC; TIGR00018 351745002598 active site 351745002599 ATP-binding site [chemical binding]; other site 351745002600 pantoate-binding site; other site 351745002601 HXXH motif; other site 351745002602 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 351745002603 oligomerization interface [polypeptide binding]; other site 351745002604 active site 351745002605 metal binding site [ion binding]; metal-binding site 351745002606 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 351745002607 catalytic center binding site [active] 351745002608 ATP binding site [chemical binding]; other site 351745002609 poly(A) polymerase; Region: pcnB; TIGR01942 351745002610 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 351745002611 active site 351745002612 NTP binding site [chemical binding]; other site 351745002613 metal binding triad [ion binding]; metal-binding site 351745002614 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 351745002615 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 351745002616 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 351745002617 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 351745002618 active site 351745002619 HIGH motif; other site 351745002620 nucleotide binding site [chemical binding]; other site 351745002621 active site 351745002622 KMSKS motif; other site 351745002623 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 351745002624 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 351745002625 aminopeptidase B; Provisional; Region: PRK05015 351745002626 Peptidase; Region: DUF3663; pfam12404 351745002627 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 351745002628 interface (dimer of trimers) [polypeptide binding]; other site 351745002629 Substrate-binding/catalytic site; other site 351745002630 Zn-binding sites [ion binding]; other site 351745002631 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 351745002632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745002633 Coenzyme A binding pocket [chemical binding]; other site 351745002634 phosphoribulokinase; Provisional; Region: PRK15453 351745002635 active site 351745002636 Uncharacterized protein family (UPF0270); Region: UPF0270; pfam06794 351745002637 putative hydrolase; Provisional; Region: PRK10985 351745002638 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 351745002639 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 351745002640 Uncharacterized conserved protein [Function unknown]; Region: COG3791 351745002641 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 351745002642 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 351745002643 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745002644 Walker A/P-loop; other site 351745002645 ATP binding site [chemical binding]; other site 351745002646 Q-loop/lid; other site 351745002647 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 351745002648 ABC transporter; Region: ABC_tran_2; pfam12848 351745002649 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 351745002650 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 351745002651 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 351745002652 Pirin-related protein [General function prediction only]; Region: COG1741 351745002653 Pirin; Region: Pirin; pfam02678 351745002654 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 351745002655 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 351745002656 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 351745002657 ATP binding site [chemical binding]; other site 351745002658 Mg++ binding site [ion binding]; other site 351745002659 motif III; other site 351745002660 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745002661 nucleotide binding region [chemical binding]; other site 351745002662 ATP-binding site [chemical binding]; other site 351745002663 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 351745002664 putative RNA binding site [nucleotide binding]; other site 351745002665 PAS domain; Region: PAS_9; pfam13426 351745002666 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745002667 putative active site [active] 351745002668 heme pocket [chemical binding]; other site 351745002669 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 351745002670 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745002671 dimer interface [polypeptide binding]; other site 351745002672 putative CheW interface [polypeptide binding]; other site 351745002673 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 351745002674 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 351745002675 ATP binding site [chemical binding]; other site 351745002676 Mg++ binding site [ion binding]; other site 351745002677 motif III; other site 351745002678 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745002679 nucleotide binding region [chemical binding]; other site 351745002680 ATP-binding site [chemical binding]; other site 351745002681 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 351745002682 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 351745002683 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 351745002684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745002685 Walker A/P-loop; other site 351745002686 ATP binding site [chemical binding]; other site 351745002687 Q-loop/lid; other site 351745002688 ABC transporter signature motif; other site 351745002689 Walker B; other site 351745002690 D-loop; other site 351745002691 H-loop/switch region; other site 351745002692 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 351745002693 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 351745002694 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745002695 Walker A/P-loop; other site 351745002696 ATP binding site [chemical binding]; other site 351745002697 Q-loop/lid; other site 351745002698 ABC transporter signature motif; other site 351745002699 Walker B; other site 351745002700 D-loop; other site 351745002701 H-loop/switch region; other site 351745002702 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 351745002703 putative active site [active] 351745002704 putative metal binding residues [ion binding]; other site 351745002705 signature motif; other site 351745002706 putative triphosphate binding site [ion binding]; other site 351745002707 dimer interface [polypeptide binding]; other site 351745002708 Helix-turn-helix domain; Region: HTH_17; pfam12728 351745002709 Protein of unknown function, DUF599; Region: DUF599; pfam04654 351745002710 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 351745002711 Proline dehydrogenase; Region: Pro_dh; pfam01619 351745002712 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 351745002713 Glutamate binding site [chemical binding]; other site 351745002714 NAD binding site [chemical binding]; other site 351745002715 catalytic residues [active] 351745002716 Bacterial SH3 domain homologues; Region: SH3b; smart00287 351745002717 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 351745002718 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 351745002719 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 351745002720 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 351745002721 Uncharacterized conserved protein [Function unknown]; Region: COG3025 351745002722 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 351745002723 putative active site [active] 351745002724 putative metal binding residues [ion binding]; other site 351745002725 signature motif; other site 351745002726 putative triphosphate binding site [ion binding]; other site 351745002727 Ion channel; Region: Ion_trans_2; pfam07885 351745002728 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 351745002729 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 351745002730 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938 351745002731 spermidine synthase; Provisional; Region: PRK03612 351745002732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 351745002733 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 351745002734 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 351745002735 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 351745002736 metal binding triad; other site 351745002737 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 351745002738 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 351745002739 metal binding triad; other site 351745002740 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 351745002741 GAF domain; Region: GAF; pfam01590 351745002742 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745002743 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745002744 metal binding site [ion binding]; metal-binding site 351745002745 active site 351745002746 I-site; other site 351745002747 Domain of unknown function (DUF897); Region: DUF897; pfam05982 351745002748 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745002749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745002750 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 351745002751 dimerization interface [polypeptide binding]; other site 351745002752 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 351745002753 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 351745002754 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 351745002755 Soluble P-type ATPase [General function prediction only]; Region: COG4087 351745002756 K+-transporting ATPase, c chain; Region: KdpC; cl00944 351745002757 K+-transporting ATPase, c chain; Region: KdpC; cl00944 351745002758 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 351745002759 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 351745002760 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 351745002761 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 351745002762 Ligand Binding Site [chemical binding]; other site 351745002763 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 351745002764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745002765 dimer interface [polypeptide binding]; other site 351745002766 phosphorylation site [posttranslational modification] 351745002767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745002768 ATP binding site [chemical binding]; other site 351745002769 Mg2+ binding site [ion binding]; other site 351745002770 G-X-G motif; other site 351745002771 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 351745002772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745002773 active site 351745002774 phosphorylation site [posttranslational modification] 351745002775 intermolecular recognition site; other site 351745002776 dimerization interface [polypeptide binding]; other site 351745002777 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745002778 DNA binding site [nucleotide binding] 351745002779 Predicted ATPase [General function prediction only]; Region: COG1485 351745002780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745002781 Walker A/P-loop; other site 351745002782 ATP binding site [chemical binding]; other site 351745002783 ABC transporter signature motif; other site 351745002784 Walker B; other site 351745002785 D-loop; other site 351745002786 H-loop/switch region; other site 351745002787 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 351745002788 putative active site [active] 351745002789 Zn binding site [ion binding]; other site 351745002790 L,D-transpeptidase; Provisional; Region: PRK10260 351745002791 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 351745002792 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 351745002793 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 351745002794 GAF domain; Region: GAF; pfam01590 351745002795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745002796 Walker A motif; other site 351745002797 ATP binding site [chemical binding]; other site 351745002798 Walker B motif; other site 351745002799 arginine finger; other site 351745002800 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 351745002801 potassium/proton antiporter; Reviewed; Region: PRK05326 351745002802 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 351745002803 TrkA-C domain; Region: TrkA_C; pfam02080 351745002804 Transporter associated domain; Region: CorC_HlyC; smart01091 351745002805 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 351745002806 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 351745002807 putative acyl-acceptor binding pocket; other site 351745002808 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 351745002809 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 351745002810 putative ribose interaction site [chemical binding]; other site 351745002811 putative ADP binding site [chemical binding]; other site 351745002812 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 351745002813 active site 351745002814 HIGH motif; other site 351745002815 nucleotide binding site [chemical binding]; other site 351745002816 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 351745002817 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 351745002818 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 351745002819 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 351745002820 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 351745002821 ligand binding site [chemical binding]; other site 351745002822 homodimer interface [polypeptide binding]; other site 351745002823 NAD(P) binding site [chemical binding]; other site 351745002824 trimer interface B [polypeptide binding]; other site 351745002825 trimer interface A [polypeptide binding]; other site 351745002826 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 351745002827 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 351745002828 Flavodoxin; Region: Flavodoxin_1; pfam00258 351745002829 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 351745002830 FAD binding pocket [chemical binding]; other site 351745002831 FAD binding motif [chemical binding]; other site 351745002832 catalytic residues [active] 351745002833 NAD binding pocket [chemical binding]; other site 351745002834 phosphate binding motif [ion binding]; other site 351745002835 beta-alpha-beta structure motif; other site 351745002836 sulfite reductase subunit beta; Provisional; Region: PRK13504 351745002837 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 351745002838 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 351745002839 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 351745002840 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 351745002841 Active Sites [active] 351745002842 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 351745002843 Transglycosylase; Region: Transgly; cl17702 351745002844 Predicted ATPase [General function prediction only]; Region: COG3903 351745002845 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 351745002846 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 351745002847 MarR family; Region: MarR; pfam01047 351745002848 FAD dependent oxidoreductase; Region: DAO; pfam01266 351745002849 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 351745002850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745002851 S-adenosylmethionine binding site [chemical binding]; other site 351745002852 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 351745002853 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 351745002854 Chromate transporter; Region: Chromate_transp; pfam02417 351745002855 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 351745002856 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745002857 dimerization interface [polypeptide binding]; other site 351745002858 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745002859 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745002860 dimer interface [polypeptide binding]; other site 351745002861 putative CheW interface [polypeptide binding]; other site 351745002862 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 351745002863 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 351745002864 catalytic loop [active] 351745002865 iron binding site [ion binding]; other site 351745002866 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 351745002867 4Fe-4S binding domain; Region: Fer4_6; pfam12837 351745002868 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 351745002869 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 351745002870 [4Fe-4S] binding site [ion binding]; other site 351745002871 molybdopterin cofactor binding site; other site 351745002872 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 351745002873 molybdopterin cofactor binding site; other site 351745002874 peptide chain release factor 2; Validated; Region: prfB; PRK00578 351745002875 This domain is found in peptide chain release factors; Region: PCRF; smart00937 351745002876 RF-1 domain; Region: RF-1; pfam00472 351745002877 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 351745002878 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 351745002879 dimer interface [polypeptide binding]; other site 351745002880 putative anticodon binding site; other site 351745002881 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 351745002882 motif 1; other site 351745002883 active site 351745002884 motif 2; other site 351745002885 motif 3; other site 351745002886 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 351745002887 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 351745002888 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 351745002889 Secreted phosphoprotein 24 (Spp-24); Region: Spp-24; pfam07448 351745002890 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 351745002891 dimerization interface [polypeptide binding]; other site 351745002892 substrate binding site [chemical binding]; other site 351745002893 active site 351745002894 calcium binding site [ion binding]; other site 351745002895 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 351745002896 active site 351745002897 SAM binding site [chemical binding]; other site 351745002898 homodimer interface [polypeptide binding]; other site 351745002899 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 351745002900 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 351745002901 Active Sites [active] 351745002902 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 351745002903 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 351745002904 CysD dimerization site [polypeptide binding]; other site 351745002905 G1 box; other site 351745002906 putative GEF interaction site [polypeptide binding]; other site 351745002907 GTP/Mg2+ binding site [chemical binding]; other site 351745002908 Switch I region; other site 351745002909 G2 box; other site 351745002910 G3 box; other site 351745002911 Switch II region; other site 351745002912 G4 box; other site 351745002913 G5 box; other site 351745002914 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 351745002915 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 351745002916 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 351745002917 TrkA-C domain; Region: TrkA_C; pfam02080 351745002918 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 351745002919 TrkA-C domain; Region: TrkA_C; pfam02080 351745002920 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 351745002921 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 351745002922 ligand-binding site [chemical binding]; other site 351745002923 TIGR03899 family protein; Region: TIGR03899 351745002924 Flavodoxin domain; Region: Flavodoxin_5; cl17428 351745002925 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 351745002926 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 351745002927 catalytic residues [active] 351745002928 hinge region; other site 351745002929 alpha helical domain; other site 351745002930 GlyGly-CTERM domain; Region: GlyGly_CTERM; TIGR03501 351745002931 DNA-J related protein; Region: DNAJ_related; pfam12339 351745002932 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 351745002933 HSP70 interaction site [polypeptide binding]; other site 351745002934 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 351745002935 FMN binding site [chemical binding]; other site 351745002936 dimer interface [polypeptide binding]; other site 351745002937 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 351745002938 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 351745002939 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 351745002940 Walker A/P-loop; other site 351745002941 ATP binding site [chemical binding]; other site 351745002942 Q-loop/lid; other site 351745002943 ABC transporter signature motif; other site 351745002944 Walker B; other site 351745002945 D-loop; other site 351745002946 H-loop/switch region; other site 351745002947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351745002948 dimer interface [polypeptide binding]; other site 351745002949 conserved gate region; other site 351745002950 putative PBP binding loops; other site 351745002951 ABC-ATPase subunit interface; other site 351745002952 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 351745002953 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 351745002954 substrate binding pocket [chemical binding]; other site 351745002955 membrane-bound complex binding site; other site 351745002956 hinge residues; other site 351745002957 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745002958 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745002959 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 351745002960 putative dimerization interface [polypeptide binding]; other site 351745002961 LrgA family; Region: LrgA; pfam03788 351745002962 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 351745002963 G4 box; other site 351745002964 LrgB-like family; Region: LrgB; pfam04172 351745002965 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 351745002966 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 351745002967 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 351745002968 Carbon starvation protein CstA; Region: CstA; pfam02554 351745002969 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 351745002970 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 351745002971 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 351745002972 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 351745002973 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 351745002974 catalytic triad [active] 351745002975 Cupin domain; Region: Cupin_2; cl17218 351745002976 Helix-turn-helix domain; Region: HTH_18; pfam12833 351745002977 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 351745002978 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 351745002979 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 351745002980 Protein of unknown function DUF72; Region: DUF72; cl00777 351745002981 PAS domain S-box; Region: sensory_box; TIGR00229 351745002982 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745002983 putative active site [active] 351745002984 heme pocket [chemical binding]; other site 351745002985 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 351745002986 GAF domain; Region: GAF; pfam01590 351745002987 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745002988 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745002989 metal binding site [ion binding]; metal-binding site 351745002990 active site 351745002991 I-site; other site 351745002992 Cache domain; Region: Cache_1; pfam02743 351745002993 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745002994 dimerization interface [polypeptide binding]; other site 351745002995 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745002996 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745002997 dimer interface [polypeptide binding]; other site 351745002998 putative CheW interface [polypeptide binding]; other site 351745002999 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 351745003000 Transposase [DNA replication, recombination, and repair]; Region: COG5421 351745003001 Lentivirus surface glycoprotein; Region: Env-gp36; pfam09590 351745003002 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 351745003003 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 351745003004 Zn binding site [ion binding]; other site 351745003005 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 351745003006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 351745003007 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 351745003008 active site 351745003009 catalytic residues [active] 351745003010 metal binding site [ion binding]; metal-binding site 351745003011 SlyX; Region: SlyX; pfam04102 351745003012 FOG: WD40 repeat [General function prediction only]; Region: COG2319 351745003013 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 351745003014 structural tetrad; other site 351745003015 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 351745003016 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 351745003017 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 351745003018 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 351745003019 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 351745003020 generic binding surface II; other site 351745003021 generic binding surface I; other site 351745003022 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 351745003023 putative catalytic site [active] 351745003024 putative metal binding site [ion binding]; other site 351745003025 putative phosphate binding site [ion binding]; other site 351745003026 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 351745003027 CoenzymeA binding site [chemical binding]; other site 351745003028 subunit interaction site [polypeptide binding]; other site 351745003029 PHB binding site; other site 351745003030 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 351745003031 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 351745003032 MAPEG family; Region: MAPEG; cl09190 351745003033 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 351745003034 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 351745003035 DNA-binding site [nucleotide binding]; DNA binding site 351745003036 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 351745003037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745003038 homodimer interface [polypeptide binding]; other site 351745003039 catalytic residue [active] 351745003040 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 351745003041 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745003042 Coenzyme A binding pocket [chemical binding]; other site 351745003043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 351745003044 glutamate racemase; Provisional; Region: PRK00865 351745003045 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 351745003046 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 351745003047 active site 351745003048 substrate binding pocket [chemical binding]; other site 351745003049 dimer interface [polypeptide binding]; other site 351745003050 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 351745003051 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 351745003052 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745003053 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 351745003054 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 351745003055 Walker A/P-loop; other site 351745003056 ATP binding site [chemical binding]; other site 351745003057 Q-loop/lid; other site 351745003058 ABC transporter signature motif; other site 351745003059 Walker B; other site 351745003060 D-loop; other site 351745003061 H-loop/switch region; other site 351745003062 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 351745003063 FtsX-like permease family; Region: FtsX; pfam02687 351745003064 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 351745003065 FtsX-like permease family; Region: FtsX; pfam02687 351745003066 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 351745003067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745003068 active site 351745003069 phosphorylation site [posttranslational modification] 351745003070 intermolecular recognition site; other site 351745003071 dimerization interface [polypeptide binding]; other site 351745003072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745003073 Walker A motif; other site 351745003074 ATP binding site [chemical binding]; other site 351745003075 Walker B motif; other site 351745003076 arginine finger; other site 351745003077 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 351745003078 HAMP domain; Region: HAMP; pfam00672 351745003079 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 351745003080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745003081 ATP binding site [chemical binding]; other site 351745003082 Mg2+ binding site [ion binding]; other site 351745003083 G-X-G motif; other site 351745003084 Curli assembly protein CsgE; Region: CsgE; pfam10627 351745003085 Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082 351745003086 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 351745003087 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 351745003088 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 351745003089 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 351745003090 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 351745003091 NAD(P) binding site [chemical binding]; other site 351745003092 catalytic residues [active] 351745003093 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 351745003094 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 351745003095 Ligand Binding Site [chemical binding]; other site 351745003096 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 351745003097 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 351745003098 substrate binding pocket [chemical binding]; other site 351745003099 membrane-bound complex binding site; other site 351745003100 hinge residues; other site 351745003101 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; pfam09904 351745003102 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 351745003103 gamma-glutamyl kinase; Provisional; Region: PRK05429 351745003104 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 351745003105 nucleotide binding site [chemical binding]; other site 351745003106 homotetrameric interface [polypeptide binding]; other site 351745003107 putative phosphate binding site [ion binding]; other site 351745003108 putative allosteric binding site; other site 351745003109 PUA domain; Region: PUA; pfam01472 351745003110 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 351745003111 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 351745003112 putative catalytic cysteine [active] 351745003113 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 351745003114 putative deacylase active site [active] 351745003115 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 351745003116 EamA-like transporter family; Region: EamA; pfam00892 351745003117 EamA-like transporter family; Region: EamA; pfam00892 351745003118 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 351745003119 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 351745003120 nucleotide binding site [chemical binding]; other site 351745003121 chaperone protein DnaJ; Provisional; Region: PRK10767 351745003122 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 351745003123 HSP70 interaction site [polypeptide binding]; other site 351745003124 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 351745003125 substrate binding site [polypeptide binding]; other site 351745003126 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 351745003127 Zn binding sites [ion binding]; other site 351745003128 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 351745003129 dimer interface [polypeptide binding]; other site 351745003130 PAS domain; Region: PAS_9; pfam13426 351745003131 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745003132 PAS domain; Region: PAS_9; pfam13426 351745003133 putative active site [active] 351745003134 heme pocket [chemical binding]; other site 351745003135 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745003136 dimer interface [polypeptide binding]; other site 351745003137 putative CheW interface [polypeptide binding]; other site 351745003138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745003139 Walker A/P-loop; other site 351745003140 ATP binding site [chemical binding]; other site 351745003141 Q-loop/lid; other site 351745003142 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 351745003143 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 351745003144 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 351745003145 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 351745003146 substrate binding pocket [chemical binding]; other site 351745003147 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 351745003148 B12 binding site [chemical binding]; other site 351745003149 cobalt ligand [ion binding]; other site 351745003150 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 351745003151 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 351745003152 catalytic core [active] 351745003153 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 351745003154 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 351745003155 Walker A/P-loop; other site 351745003156 ATP binding site [chemical binding]; other site 351745003157 Q-loop/lid; other site 351745003158 ABC transporter signature motif; other site 351745003159 Walker B; other site 351745003160 D-loop; other site 351745003161 H-loop/switch region; other site 351745003162 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 351745003163 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 351745003164 ABC-ATPase subunit interface; other site 351745003165 dimer interface [polypeptide binding]; other site 351745003166 putative PBP binding regions; other site 351745003167 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 351745003168 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 351745003169 putative dimer interface [polypeptide binding]; other site 351745003170 active site pocket [active] 351745003171 putative cataytic base [active] 351745003172 cobalamin synthase; Reviewed; Region: cobS; PRK00235 351745003173 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 351745003174 homotrimer interface [polypeptide binding]; other site 351745003175 Walker A motif; other site 351745003176 GTP binding site [chemical binding]; other site 351745003177 Walker B motif; other site 351745003178 cobyric acid synthase; Provisional; Region: PRK00784 351745003179 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 351745003180 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 351745003181 catalytic triad [active] 351745003182 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 351745003183 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 351745003184 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 351745003185 homodimer interface [polypeptide binding]; other site 351745003186 Walker A motif; other site 351745003187 ATP binding site [chemical binding]; other site 351745003188 hydroxycobalamin binding site [chemical binding]; other site 351745003189 Walker B motif; other site 351745003190 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 351745003191 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 351745003192 Int/Topo IB signature motif; other site 351745003193 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 351745003194 Putative transposase; Region: Y2_Tnp; pfam04986 351745003195 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 351745003196 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 351745003197 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 351745003198 cobalamin binding residues [chemical binding]; other site 351745003199 putative BtuC binding residues; other site 351745003200 dimer interface [polypeptide binding]; other site 351745003201 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 351745003202 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 351745003203 NAD(P) binding site [chemical binding]; other site 351745003204 catalytic residues [active] 351745003205 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 351745003206 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 351745003207 dimer interface [polypeptide binding]; other site 351745003208 active site 351745003209 metal binding site [ion binding]; metal-binding site 351745003210 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 351745003211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 351745003212 ATP binding site [chemical binding]; other site 351745003213 putative Mg++ binding site [ion binding]; other site 351745003214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745003215 nucleotide binding region [chemical binding]; other site 351745003216 ATP-binding site [chemical binding]; other site 351745003217 Peptidase family M48; Region: Peptidase_M48; pfam01435 351745003218 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 351745003219 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 351745003220 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 351745003221 dihydrodipicolinate reductase; Provisional; Region: PRK00048 351745003222 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 351745003223 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 351745003224 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 351745003225 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 351745003226 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 351745003227 catalytic site [active] 351745003228 subunit interface [polypeptide binding]; other site 351745003229 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 351745003230 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 351745003231 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 351745003232 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 351745003233 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 351745003234 ATP-grasp domain; Region: ATP-grasp_4; cl17255 351745003235 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 351745003236 IMP binding site; other site 351745003237 dimer interface [polypeptide binding]; other site 351745003238 interdomain contacts; other site 351745003239 partial ornithine binding site; other site 351745003240 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 351745003241 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 351745003242 active site 351745003243 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 351745003244 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 351745003245 substrate binding pocket [chemical binding]; other site 351745003246 membrane-bound complex binding site; other site 351745003247 hinge residues; other site 351745003248 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745003249 dimer interface [polypeptide binding]; other site 351745003250 putative CheW interface [polypeptide binding]; other site 351745003251 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 351745003252 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 351745003253 MgtE intracellular N domain; Region: MgtE_N; pfam03448 351745003254 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 351745003255 Divalent cation transporter; Region: MgtE; pfam01769 351745003256 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 351745003257 putative metal binding site [ion binding]; other site 351745003258 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 351745003259 Transposase [DNA replication, recombination, and repair]; Region: COG5421 351745003260 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 351745003261 putative catalytic site [active] 351745003262 putative phosphate binding site [ion binding]; other site 351745003263 putative metal binding site [ion binding]; other site 351745003264 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 351745003265 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 351745003266 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 351745003267 putative RNA binding site [nucleotide binding]; other site 351745003268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745003269 S-adenosylmethionine binding site [chemical binding]; other site 351745003270 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 351745003271 tetramer (dimer of dimers) interface [polypeptide binding]; other site 351745003272 active site 351745003273 dimer interface [polypeptide binding]; other site 351745003274 Protein of unknown function (DUF808); Region: DUF808; pfam05661 351745003275 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 351745003276 catalytic site [active] 351745003277 putative active site [active] 351745003278 putative substrate binding site [chemical binding]; other site 351745003279 SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102 351745003280 SEC-C motif; Region: SEC-C; pfam02810 351745003281 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 351745003282 DNA binding site [nucleotide binding] 351745003283 active site 351745003284 Int/Topo IB signature motif; other site 351745003285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 351745003286 binding surface 351745003287 TPR motif; other site 351745003288 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 351745003289 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 351745003290 Integrase core domain; Region: rve; pfam00665 351745003291 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 351745003292 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745003293 N-terminal plug; other site 351745003294 ligand-binding site [chemical binding]; other site 351745003295 Predicted membrane protein [Function unknown]; Region: COG3503 351745003296 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 351745003297 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 351745003298 dimerization interface [polypeptide binding]; other site 351745003299 DPS ferroxidase diiron center [ion binding]; other site 351745003300 ion pore; other site 351745003301 DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436 351745003302 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 351745003303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745003304 Coenzyme A binding pocket [chemical binding]; other site 351745003305 lipoyl synthase; Provisional; Region: PRK05481 351745003306 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351745003307 FeS/SAM binding site; other site 351745003308 lipoate-protein ligase B; Provisional; Region: PRK14342 351745003309 hypothetical protein; Provisional; Region: PRK04998 351745003310 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 351745003311 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 351745003312 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 351745003313 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 351745003314 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 351745003315 Sporulation related domain; Region: SPOR; pfam05036 351745003316 Transglycosylase SLT domain; Region: SLT_2; pfam13406 351745003317 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 351745003318 N-acetyl-D-glucosamine binding site [chemical binding]; other site 351745003319 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 351745003320 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 351745003321 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 351745003322 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 351745003323 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 351745003324 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 351745003325 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 351745003326 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 351745003327 active site 351745003328 (T/H)XGH motif; other site 351745003329 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 351745003330 DNA polymerase III, delta subunit; Region: holA; TIGR01128 351745003331 Lipopolysaccharide-assembly; Region: LptE; cl01125 351745003332 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 351745003333 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 351745003334 HIGH motif; other site 351745003335 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 351745003336 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 351745003337 active site 351745003338 KMSKS motif; other site 351745003339 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 351745003340 tRNA binding surface [nucleotide binding]; other site 351745003341 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 351745003342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745003343 S-adenosylmethionine binding site [chemical binding]; other site 351745003344 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 351745003345 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 351745003346 putative active site [active] 351745003347 catalytic triad [active] 351745003348 putative dimer interface [polypeptide binding]; other site 351745003349 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 351745003350 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 351745003351 Transporter associated domain; Region: CorC_HlyC; smart01091 351745003352 metal-binding heat shock protein; Provisional; Region: PRK00016 351745003353 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 351745003354 PhoH-like protein; Region: PhoH; pfam02562 351745003355 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 351745003356 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 351745003357 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351745003358 FeS/SAM binding site; other site 351745003359 TRAM domain; Region: TRAM; pfam01938 351745003360 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 351745003361 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK08849 351745003362 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 351745003363 putative active site [active] 351745003364 catalytic residue [active] 351745003365 GTP-binding protein YchF; Reviewed; Region: PRK09601 351745003366 YchF GTPase; Region: YchF; cd01900 351745003367 G1 box; other site 351745003368 GTP/Mg2+ binding site [chemical binding]; other site 351745003369 Switch I region; other site 351745003370 G2 box; other site 351745003371 Switch II region; other site 351745003372 G3 box; other site 351745003373 G4 box; other site 351745003374 G5 box; other site 351745003375 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 351745003376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 351745003377 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 351745003378 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 351745003379 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 351745003380 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 351745003381 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 351745003382 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK12933 351745003383 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 351745003384 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 351745003385 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13021 351745003386 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 351745003387 Protein export membrane protein; Region: SecD_SecF; pfam02355 351745003388 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 351745003389 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 351745003390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745003391 S-adenosylmethionine binding site [chemical binding]; other site 351745003392 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 351745003393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745003394 Walker A motif; other site 351745003395 ATP binding site [chemical binding]; other site 351745003396 Walker B motif; other site 351745003397 arginine finger; other site 351745003398 Peptidase family M41; Region: Peptidase_M41; pfam01434 351745003399 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 351745003400 dihydropteroate synthase; Region: DHPS; TIGR01496 351745003401 substrate binding pocket [chemical binding]; other site 351745003402 dimer interface [polypeptide binding]; other site 351745003403 inhibitor binding site; inhibition site 351745003404 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 351745003405 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 351745003406 active site 351745003407 substrate binding site [chemical binding]; other site 351745003408 metal binding site [ion binding]; metal-binding site 351745003409 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 351745003410 triosephosphate isomerase; Provisional; Region: PRK14567 351745003411 substrate binding site [chemical binding]; other site 351745003412 dimer interface [polypeptide binding]; other site 351745003413 catalytic triad [active] 351745003414 Preprotein translocase SecG subunit; Region: SecG; pfam03840 351745003415 ribosome maturation protein RimP; Reviewed; Region: PRK00092 351745003416 Sm and related proteins; Region: Sm_like; cl00259 351745003417 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 351745003418 putative oligomer interface [polypeptide binding]; other site 351745003419 putative RNA binding site [nucleotide binding]; other site 351745003420 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 351745003421 NusA N-terminal domain; Region: NusA_N; pfam08529 351745003422 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 351745003423 RNA binding site [nucleotide binding]; other site 351745003424 homodimer interface [polypeptide binding]; other site 351745003425 NusA-like KH domain; Region: KH_5; pfam13184 351745003426 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 351745003427 G-X-X-G motif; other site 351745003428 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 351745003429 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 351745003430 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 351745003431 translation initiation factor IF-2; Region: IF-2; TIGR00487 351745003432 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 351745003433 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 351745003434 G1 box; other site 351745003435 putative GEF interaction site [polypeptide binding]; other site 351745003436 GTP/Mg2+ binding site [chemical binding]; other site 351745003437 Switch I region; other site 351745003438 G2 box; other site 351745003439 G3 box; other site 351745003440 Switch II region; other site 351745003441 G4 box; other site 351745003442 G5 box; other site 351745003443 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 351745003444 Translation-initiation factor 2; Region: IF-2; pfam11987 351745003445 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 351745003446 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 351745003447 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 351745003448 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 351745003449 RNA binding site [nucleotide binding]; other site 351745003450 active site 351745003451 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 351745003452 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 351745003453 16S/18S rRNA binding site [nucleotide binding]; other site 351745003454 S13e-L30e interaction site [polypeptide binding]; other site 351745003455 25S rRNA binding site [nucleotide binding]; other site 351745003456 biofilm formation regulator HmsP; Provisional; Region: PRK11829 351745003457 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745003458 metal binding site [ion binding]; metal-binding site 351745003459 active site 351745003460 I-site; other site 351745003461 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745003462 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 351745003463 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 351745003464 RNase E interface [polypeptide binding]; other site 351745003465 trimer interface [polypeptide binding]; other site 351745003466 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 351745003467 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 351745003468 RNase E interface [polypeptide binding]; other site 351745003469 trimer interface [polypeptide binding]; other site 351745003470 active site 351745003471 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 351745003472 putative nucleic acid binding region [nucleotide binding]; other site 351745003473 G-X-X-G motif; other site 351745003474 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 351745003475 RNA binding site [nucleotide binding]; other site 351745003476 domain interface; other site 351745003477 lipoprotein NlpI; Provisional; Region: PRK11189 351745003478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 351745003479 binding surface 351745003480 TPR motif; other site 351745003481 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 351745003482 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 351745003483 active site 351745003484 Int/Topo IB signature motif; other site 351745003485 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 351745003486 PRTRC system protein D; Region: PRTRC_D; TIGR03739 351745003487 Mg binding site [ion binding]; other site 351745003488 nucleotide binding site [chemical binding]; other site 351745003489 putative protofilament interface [polypeptide binding]; other site 351745003490 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 351745003491 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 351745003492 active site 351745003493 DNA binding site [nucleotide binding] 351745003494 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 351745003495 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 351745003496 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 351745003497 Catalytic site [active] 351745003498 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 351745003499 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 351745003500 active site 351745003501 catalytic site [active] 351745003502 substrate binding site [chemical binding]; other site 351745003503 Predicted transcriptional regulator [Transcription]; Region: COG2378 351745003504 WYL domain; Region: WYL; pfam13280 351745003505 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 351745003506 HsdM N-terminal domain; Region: HsdM_N; pfam12161 351745003507 Methyltransferase domain; Region: Methyltransf_26; pfam13659 351745003508 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 351745003509 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 351745003510 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 351745003511 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 351745003512 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 351745003513 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 351745003514 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 351745003515 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351745003516 ATP binding site [chemical binding]; other site 351745003517 putative Mg++ binding site [ion binding]; other site 351745003518 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 351745003519 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 351745003520 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 351745003521 active site 351745003522 NTP binding site [chemical binding]; other site 351745003523 metal binding triad [ion binding]; metal-binding site 351745003524 Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; Region: UBCc; cl00154 351745003525 Putative helicase; Region: TraI_2; pfam07514 351745003526 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 351745003527 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 351745003528 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 351745003529 Domain of unknown function (DUF4400); Region: DUF4400; pfam14348 351745003530 replicative DNA helicase; Provisional; Region: PRK05973 351745003531 TraL protein; Region: TraL; cl06278 351745003532 TraE protein; Region: TraE; cl05060 351745003533 TraK protein; Region: TraK; pfam06586 351745003534 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 351745003535 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 351745003536 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 351745003537 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 351745003538 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 351745003539 metal-binding site [ion binding] 351745003540 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 351745003541 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 351745003542 metal-binding site [ion binding] 351745003543 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 351745003544 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351745003545 motif II; other site 351745003546 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 351745003547 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 351745003548 DNA binding residues [nucleotide binding] 351745003549 dimer interface [polypeptide binding]; other site 351745003550 copper binding site [ion binding]; other site 351745003551 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 351745003552 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 351745003553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745003554 Walker A motif; other site 351745003555 ATP binding site [chemical binding]; other site 351745003556 Walker B motif; other site 351745003557 arginine finger; other site 351745003558 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 351745003559 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 351745003560 DNA binding residues [nucleotide binding] 351745003561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 351745003562 Integrase core domain; Region: rve; pfam00665 351745003563 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 351745003564 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 351745003565 Integrase core domain; Region: rve; pfam00665 351745003566 transposase; Validated; Region: PRK08181 351745003567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745003568 Walker A motif; other site 351745003569 ATP binding site [chemical binding]; other site 351745003570 Walker B motif; other site 351745003571 putative transposase OrfB; Reviewed; Region: PHA02517 351745003572 HTH-like domain; Region: HTH_21; pfam13276 351745003573 Integrase core domain; Region: rve; pfam00665 351745003574 Integrase core domain; Region: rve_3; pfam13683 351745003575 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 351745003576 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 351745003577 DNA binding residues [nucleotide binding] 351745003578 dimer interface [polypeptide binding]; other site 351745003579 copper binding site [ion binding]; other site 351745003580 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 351745003581 dimerization interface [polypeptide binding]; other site 351745003582 putative DNA binding site [nucleotide binding]; other site 351745003583 putative Zn2+ binding site [ion binding]; other site 351745003584 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 351745003585 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 351745003586 dimerization interface [polypeptide binding]; other site 351745003587 putative DNA binding site [nucleotide binding]; other site 351745003588 putative Zn2+ binding site [ion binding]; other site 351745003589 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 351745003590 metal-binding site [ion binding] 351745003591 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 351745003592 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 351745003593 metal-binding site [ion binding] 351745003594 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 351745003595 Soluble P-type ATPase [General function prediction only]; Region: COG4087 351745003596 putative transposase OrfB; Reviewed; Region: PHA02517 351745003597 HTH-like domain; Region: HTH_21; pfam13276 351745003598 Integrase core domain; Region: rve; pfam00665 351745003599 Integrase core domain; Region: rve_3; pfam13683 351745003600 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 351745003601 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 351745003602 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745003603 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 351745003604 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 351745003605 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 351745003606 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 351745003607 metal-binding site [ion binding] 351745003608 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 351745003609 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 351745003610 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 351745003611 dimerization domain [polypeptide binding]; other site 351745003612 dimer interface [polypeptide binding]; other site 351745003613 catalytic residues [active] 351745003614 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 351745003615 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 351745003616 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 351745003617 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 351745003618 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 351745003619 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 351745003620 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 351745003621 TraU protein; Region: TraU; pfam06834 351745003622 conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14876 351745003623 conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14876 351745003624 Dynamin family; Region: Dynamin_N; pfam00350 351745003625 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 351745003626 G1 box; other site 351745003627 GTP/Mg2+ binding site [chemical binding]; other site 351745003628 G2 box; other site 351745003629 Switch I region; other site 351745003630 Endonuclease I; Region: Endonuclease_1; pfam04231 351745003631 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 351745003632 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 351745003633 dimer interface [polypeptide binding]; other site 351745003634 ssDNA binding site [nucleotide binding]; other site 351745003635 tetramer (dimer of dimers) interface [polypeptide binding]; other site 351745003636 RecT family; Region: RecT; cl04285 351745003637 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 351745003638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745003639 Walker A motif; other site 351745003640 ATP binding site [chemical binding]; other site 351745003641 Walker B motif; other site 351745003642 arginine finger; other site 351745003643 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 351745003644 WGR domain; Region: WGR; cl01581 351745003645 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 351745003646 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 351745003647 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 351745003648 metal ion-dependent adhesion site (MIDAS); other site 351745003649 hypothetical protein; Reviewed; Region: PRK00024 351745003650 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 351745003651 MPN+ (JAMM) motif; other site 351745003652 Zinc-binding site [ion binding]; other site 351745003653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 351745003654 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; pfam08273 351745003655 Toprim domain; Region: Toprim_3; pfam13362 351745003656 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 351745003657 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 351745003658 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 351745003659 carboxyltransferase (CT) interaction site; other site 351745003660 biotinylation site [posttranslational modification]; other site 351745003661 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745003662 putative membrane fusion protein; Region: TIGR02828 351745003663 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 351745003664 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 351745003665 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 351745003666 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 351745003667 DNA binding residues [nucleotide binding] 351745003668 dimer interface [polypeptide binding]; other site 351745003669 putative metal binding site [ion binding]; other site 351745003670 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 351745003671 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 351745003672 hypothetical protein; Provisional; Region: PRK02237 351745003673 F plasmid transfer operon protein; Region: TraF; pfam13728 351745003674 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 351745003675 catalytic residues [active] 351745003676 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 351745003677 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 351745003678 Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036 351745003679 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012 351745003680 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 351745003681 N-acetyl-D-glucosamine binding site [chemical binding]; other site 351745003682 catalytic residue [active] 351745003683 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 351745003684 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 351745003685 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 351745003686 non-specific DNA binding site [nucleotide binding]; other site 351745003687 salt bridge; other site 351745003688 sequence-specific DNA binding site [nucleotide binding]; other site 351745003689 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 351745003690 Catalytic site [active] 351745003691 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 351745003692 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 351745003693 G1 box; other site 351745003694 putative GEF interaction site [polypeptide binding]; other site 351745003695 GTP/Mg2+ binding site [chemical binding]; other site 351745003696 Switch I region; other site 351745003697 G2 box; other site 351745003698 G3 box; other site 351745003699 Switch II region; other site 351745003700 G4 box; other site 351745003701 G5 box; other site 351745003702 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 351745003703 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 351745003704 active site 351745003705 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 351745003706 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 351745003707 Nucleoside recognition; Region: Gate; pfam07670 351745003708 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 351745003709 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 351745003710 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 351745003711 intersubunit interface [polypeptide binding]; other site 351745003712 active site 351745003713 catalytic residue [active] 351745003714 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 351745003715 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 351745003716 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 351745003717 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 351745003718 phosphopentomutase; Provisional; Region: PRK05362 351745003719 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 351745003720 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 351745003721 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 351745003722 phosphoserine phosphatase SerB; Region: serB; TIGR00338 351745003723 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351745003724 motif II; other site 351745003725 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 351745003726 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 351745003727 PilZ domain; Region: PilZ; pfam07238 351745003728 PilZ domain; Region: PilZ; pfam07238 351745003729 DNA repair protein RadA; Provisional; Region: PRK11823 351745003730 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 351745003731 Walker A motif/ATP binding site; other site 351745003732 ATP binding site [chemical binding]; other site 351745003733 Walker B motif; other site 351745003734 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 351745003735 PilZ domain; Region: PilZ; pfam07238 351745003736 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 351745003737 FOG: CBS domain [General function prediction only]; Region: COG0517 351745003738 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_24; cd04637 351745003739 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 351745003740 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 351745003741 putative acyl-acceptor binding pocket; other site 351745003742 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 351745003743 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 351745003744 putative active site [active] 351745003745 putative metal binding site [ion binding]; other site 351745003746 AAA domain; Region: AAA_13; pfam13166 351745003747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 351745003748 Nucleoside recognition; Region: Gate; pfam07670 351745003749 Predicted membrane protein [Function unknown]; Region: COG3371 351745003750 putative protease; Provisional; Region: PRK15447 351745003751 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 351745003752 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 351745003753 Peptidase family U32; Region: Peptidase_U32; pfam01136 351745003754 SCP-2 sterol transfer family; Region: SCP2; cl01225 351745003755 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 351745003756 putative protease; Provisional; Region: PRK15452 351745003757 Peptidase family U32; Region: Peptidase_U32; pfam01136 351745003758 HDOD domain; Region: HDOD; pfam08668 351745003759 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745003760 metal binding site [ion binding]; metal-binding site 351745003761 active site 351745003762 I-site; other site 351745003763 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745003764 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 351745003765 active site 351745003766 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 351745003767 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 351745003768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745003769 active site 351745003770 phosphorylation site [posttranslational modification] 351745003771 intermolecular recognition site; other site 351745003772 dimerization interface [polypeptide binding]; other site 351745003773 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 351745003774 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 351745003775 GDP-binding site [chemical binding]; other site 351745003776 ACT binding site; other site 351745003777 IMP binding site; other site 351745003778 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745003779 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745003780 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 351745003781 dimerization interface [polypeptide binding]; other site 351745003782 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 351745003783 OsmC-like protein; Region: OsmC; pfam02566 351745003784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 351745003785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 351745003786 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 351745003787 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 351745003788 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745003789 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 351745003790 Uncharacterized conserved protein [Function unknown]; Region: COG1432 351745003791 LabA_like proteins; Region: LabA_like/DUF88; cl10034 351745003792 putative metal binding site [ion binding]; other site 351745003793 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 351745003794 Helix-turn-helix domain; Region: HTH_18; pfam12833 351745003795 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 351745003796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745003797 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 351745003798 putative substrate translocation pore; other site 351745003799 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 351745003800 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 351745003801 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 351745003802 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745003803 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 351745003804 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 351745003805 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 351745003806 catalytic residues [active] 351745003807 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 351745003808 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745003809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745003810 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 351745003811 putative effector binding pocket; other site 351745003812 dimerization interface [polypeptide binding]; other site 351745003813 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 351745003814 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 351745003815 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 351745003816 ABC transporter; Region: ABC_tran_2; pfam12848 351745003817 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 351745003818 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 351745003819 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 351745003820 dimer interface [polypeptide binding]; other site 351745003821 active site 351745003822 glycine-pyridoxal phosphate binding site [chemical binding]; other site 351745003823 folate binding site [chemical binding]; other site 351745003824 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 351745003825 ATP cone domain; Region: ATP-cone; pfam03477 351745003826 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 351745003827 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 351745003828 catalytic motif [active] 351745003829 Zn binding site [ion binding]; other site 351745003830 RibD C-terminal domain; Region: RibD_C; cl17279 351745003831 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 351745003832 Lumazine binding domain; Region: Lum_binding; pfam00677 351745003833 Lumazine binding domain; Region: Lum_binding; pfam00677 351745003834 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 351745003835 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 351745003836 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 351745003837 dimerization interface [polypeptide binding]; other site 351745003838 active site 351745003839 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 351745003840 homopentamer interface [polypeptide binding]; other site 351745003841 active site 351745003842 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 351745003843 putative RNA binding site [nucleotide binding]; other site 351745003844 thiamine monophosphate kinase; Provisional; Region: PRK05731 351745003845 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 351745003846 ATP binding site [chemical binding]; other site 351745003847 dimerization interface [polypeptide binding]; other site 351745003848 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 351745003849 tetramer interfaces [polypeptide binding]; other site 351745003850 binuclear metal-binding site [ion binding]; other site 351745003851 recombination and repair protein; Provisional; Region: PRK10869 351745003852 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 351745003853 Walker A/P-loop; other site 351745003854 ATP binding site [chemical binding]; other site 351745003855 Q-loop/lid; other site 351745003856 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 351745003857 ABC transporter signature motif; other site 351745003858 Walker B; other site 351745003859 D-loop; other site 351745003860 H-loop/switch region; other site 351745003861 Predicted permeases [General function prediction only]; Region: COG0679 351745003862 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745003863 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745003864 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 351745003865 putative effector binding pocket; other site 351745003866 dimerization interface [polypeptide binding]; other site 351745003867 Protein of unknown function (DUF416); Region: DUF416; pfam04222 351745003868 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 351745003869 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 351745003870 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745003871 dimerization interface [polypeptide binding]; other site 351745003872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745003873 dimer interface [polypeptide binding]; other site 351745003874 phosphorylation site [posttranslational modification] 351745003875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745003876 ATP binding site [chemical binding]; other site 351745003877 Mg2+ binding site [ion binding]; other site 351745003878 G-X-G motif; other site 351745003879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745003880 active site 351745003881 phosphorylation site [posttranslational modification] 351745003882 intermolecular recognition site; other site 351745003883 dimerization interface [polypeptide binding]; other site 351745003884 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 351745003885 putative binding surface; other site 351745003886 active site 351745003887 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 351745003888 TRAM domain; Region: TRAM; pfam01938 351745003889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745003890 S-adenosylmethionine binding site [chemical binding]; other site 351745003891 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 351745003892 HD domain; Region: HD_4; pfam13328 351745003893 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 351745003894 synthetase active site [active] 351745003895 NTP binding site [chemical binding]; other site 351745003896 metal binding site [ion binding]; metal-binding site 351745003897 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 351745003898 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 351745003899 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 351745003900 AAA domain; Region: AAA_11; pfam13086 351745003901 Part of AAA domain; Region: AAA_19; pfam13245 351745003902 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 351745003903 AAA domain; Region: AAA_12; pfam13087 351745003904 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 351745003905 putative active site [active] 351745003906 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 351745003907 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 351745003908 methionine synthase; Provisional; Region: PRK01207 351745003909 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 351745003910 substrate binding site [chemical binding]; other site 351745003911 THF binding site; other site 351745003912 zinc-binding site [ion binding]; other site 351745003913 amidase; Validated; Region: PRK06565 351745003914 Amidase; Region: Amidase; cl11426 351745003915 Amidase; Region: Amidase; cl11426 351745003916 agmatine deiminase; Provisional; Region: PRK13551 351745003917 agmatine deiminase; Region: agmatine_aguA; TIGR03380 351745003918 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 351745003919 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 351745003920 homodimer interface [polypeptide binding]; other site 351745003921 metal binding site [ion binding]; metal-binding site 351745003922 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 351745003923 homodimer interface [polypeptide binding]; other site 351745003924 active site 351745003925 putative chemical substrate binding site [chemical binding]; other site 351745003926 metal binding site [ion binding]; metal-binding site 351745003927 CTP synthetase; Validated; Region: pyrG; PRK05380 351745003928 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 351745003929 Catalytic site [active] 351745003930 active site 351745003931 UTP binding site [chemical binding]; other site 351745003932 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 351745003933 active site 351745003934 putative oxyanion hole; other site 351745003935 catalytic triad [active] 351745003936 enolase; Provisional; Region: eno; PRK00077 351745003937 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 351745003938 dimer interface [polypeptide binding]; other site 351745003939 metal binding site [ion binding]; metal-binding site 351745003940 substrate binding pocket [chemical binding]; other site 351745003941 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 351745003942 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 351745003943 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 351745003944 substrate binding site; other site 351745003945 dimer interface; other site 351745003946 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 351745003947 homotrimer interaction site [polypeptide binding]; other site 351745003948 zinc binding site [ion binding]; other site 351745003949 CDP-binding sites; other site 351745003950 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 351745003951 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 351745003952 Permutation of conserved domain; other site 351745003953 active site 351745003954 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 351745003955 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 351745003956 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 351745003957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745003958 S-adenosylmethionine binding site [chemical binding]; other site 351745003959 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 351745003960 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 351745003961 Peptidase family M23; Region: Peptidase_M23; pfam01551 351745003962 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 351745003963 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 351745003964 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 351745003965 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 351745003966 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 351745003967 DNA binding residues [nucleotide binding] 351745003968 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 351745003969 MutS domain I; Region: MutS_I; pfam01624 351745003970 MutS domain II; Region: MutS_II; pfam05188 351745003971 MutS domain III; Region: MutS_III; pfam05192 351745003972 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 351745003973 Walker A/P-loop; other site 351745003974 ATP binding site [chemical binding]; other site 351745003975 Q-loop/lid; other site 351745003976 ABC transporter signature motif; other site 351745003977 Walker B; other site 351745003978 D-loop; other site 351745003979 H-loop/switch region; other site 351745003980 recombinase A; Provisional; Region: recA; PRK09354 351745003981 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 351745003982 hexamer interface [polypeptide binding]; other site 351745003983 Walker A motif; other site 351745003984 ATP binding site [chemical binding]; other site 351745003985 Walker B motif; other site 351745003986 RecX family; Region: RecX; pfam02631 351745003987 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 351745003988 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 351745003989 motif 1; other site 351745003990 active site 351745003991 motif 2; other site 351745003992 motif 3; other site 351745003993 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 351745003994 DHHA1 domain; Region: DHHA1; pfam02272 351745003995 aspartate kinase; Reviewed; Region: PRK06635 351745003996 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 351745003997 putative nucleotide binding site [chemical binding]; other site 351745003998 putative catalytic residues [active] 351745003999 putative Mg ion binding site [ion binding]; other site 351745004000 putative aspartate binding site [chemical binding]; other site 351745004001 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 351745004002 putative allosteric regulatory residue; other site 351745004003 carbon storage regulator; Provisional; Region: PRK01712 351745004004 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 351745004005 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 351745004006 HIGH motif; other site 351745004007 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 351745004008 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 351745004009 active site 351745004010 KMSKS motif; other site 351745004011 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 351745004012 tRNA binding surface [nucleotide binding]; other site 351745004013 anticodon binding site; other site 351745004014 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 351745004015 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 351745004016 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 351745004017 30S subunit binding site; other site 351745004018 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 351745004019 Cytochrome C' Region: Cytochrom_C_2; pfam01322 351745004020 Trp repressor protein; Region: Trp_repressor; pfam01371 351745004021 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 351745004022 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 351745004023 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 351745004024 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 351745004025 putative catalytic residues [active] 351745004026 putative nucleotide binding site [chemical binding]; other site 351745004027 putative aspartate binding site [chemical binding]; other site 351745004028 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 351745004029 dimer interface [polypeptide binding]; other site 351745004030 putative threonine allosteric regulatory site; other site 351745004031 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 351745004032 putative threonine allosteric regulatory site; other site 351745004033 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 351745004034 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 351745004035 homoserine kinase; Provisional; Region: PRK01212 351745004036 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 351745004037 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 351745004038 threonine synthase; Validated; Region: PRK09225 351745004039 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 351745004040 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 351745004041 catalytic residue [active] 351745004042 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 351745004043 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 351745004044 substrate binding pocket [chemical binding]; other site 351745004045 membrane-bound complex binding site; other site 351745004046 hinge residues; other site 351745004047 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 351745004048 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 351745004049 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 351745004050 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 351745004051 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 351745004052 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 351745004053 protein binding site [polypeptide binding]; other site 351745004054 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 351745004055 Domain interface; other site 351745004056 Peptide binding site; other site 351745004057 Active site tetrad [active] 351745004058 OsmC-like protein; Region: OsmC; cl00767 351745004059 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 351745004060 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 351745004061 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 351745004062 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 351745004063 Protein of unknown function (DUF3649); Region: DUF3649; pfam12365 351745004064 PAS domain; Region: PAS_9; pfam13426 351745004065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745004066 putative active site [active] 351745004067 heme pocket [chemical binding]; other site 351745004068 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745004069 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745004070 dimer interface [polypeptide binding]; other site 351745004071 putative CheW interface [polypeptide binding]; other site 351745004072 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 351745004073 30S subunit binding site; other site 351745004074 hypothetical protein; Provisional; Region: PRK12378 351745004075 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 351745004076 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745004077 dimer interface [polypeptide binding]; other site 351745004078 putative CheW interface [polypeptide binding]; other site 351745004079 Protein of unknown function (DUF2375); Region: DUF2375; pfam09558 351745004080 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 351745004081 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 351745004082 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 351745004083 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 351745004084 FMN binding site [chemical binding]; other site 351745004085 active site 351745004086 substrate binding site [chemical binding]; other site 351745004087 catalytic residue [active] 351745004088 AAA domain; Region: AAA_32; pfam13654 351745004089 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 351745004090 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 351745004091 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 351745004092 DEAD-like helicases superfamily; Region: DEXDc; smart00487 351745004093 ATP binding site [chemical binding]; other site 351745004094 Mg++ binding site [ion binding]; other site 351745004095 motif III; other site 351745004096 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745004097 nucleotide binding region [chemical binding]; other site 351745004098 ATP-binding site [chemical binding]; other site 351745004099 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 351745004100 Protein of unknown function (DUF523); Region: DUF523; pfam04463 351745004101 Uncharacterized conserved protein [Function unknown]; Region: COG3272 351745004102 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 351745004103 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 351745004104 DNA binding residues [nucleotide binding] 351745004105 DNA photolyase; Region: DNA_photolyase; pfam00875 351745004106 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 351745004107 SnoaL-like domain; Region: SnoaL_2; pfam12680 351745004108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 351745004109 NAD(P) binding site [chemical binding]; other site 351745004110 active site 351745004111 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 351745004112 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 351745004113 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 351745004114 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 351745004115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745004116 S-adenosylmethionine binding site [chemical binding]; other site 351745004117 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 351745004118 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 351745004119 Protein of unknown function (DUF3634); Region: DUF3634; pfam12321 351745004120 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 351745004121 hypothetical protein; Provisional; Region: PRK03757 351745004122 oxidative damage protection protein; Provisional; Region: PRK05408 351745004123 adenine DNA glycosylase; Provisional; Region: PRK10880 351745004124 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 351745004125 minor groove reading motif; other site 351745004126 helix-hairpin-helix signature motif; other site 351745004127 substrate binding pocket [chemical binding]; other site 351745004128 active site 351745004129 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 351745004130 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 351745004131 DNA binding and oxoG recognition site [nucleotide binding] 351745004132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745004133 S-adenosylmethionine binding site [chemical binding]; other site 351745004134 hypothetical protein; Provisional; Region: PRK11702 351745004135 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 351745004136 glutaminase; Provisional; Region: PRK00971 351745004137 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 351745004138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745004139 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745004140 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 351745004141 putative effector binding pocket; other site 351745004142 dimerization interface [polypeptide binding]; other site 351745004143 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 351745004144 HemN family oxidoreductase; Provisional; Region: PRK05660 351745004145 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351745004146 FeS/SAM binding site; other site 351745004147 HemN C-terminal domain; Region: HemN_C; pfam06969 351745004148 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 351745004149 active site 351745004150 dimerization interface [polypeptide binding]; other site 351745004151 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 351745004152 hypothetical protein; Validated; Region: PRK05090 351745004153 YGGT family; Region: YGGT; pfam02325 351745004154 YGGT family; Region: YGGT; pfam02325 351745004155 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 351745004156 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 351745004157 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 351745004158 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 351745004159 catalytic residue [active] 351745004160 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 351745004161 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 351745004162 Walker A motif; other site 351745004163 ATP binding site [chemical binding]; other site 351745004164 Walker B motif; other site 351745004165 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 351745004166 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 351745004167 Walker A motif; other site 351745004168 ATP binding site [chemical binding]; other site 351745004169 Walker B motif; other site 351745004170 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 351745004171 catalytic residues [active] 351745004172 dimer interface [polypeptide binding]; other site 351745004173 ferrochelatase; Reviewed; Region: hemH; PRK00035 351745004174 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 351745004175 active site 351745004176 C-terminal domain interface [polypeptide binding]; other site 351745004177 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 351745004178 active site 351745004179 N-terminal domain interface [polypeptide binding]; other site 351745004180 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 351745004181 hypothetical protein; Validated; Region: PRK00228 351745004182 translation initiation factor Sui1; Validated; Region: PRK06824 351745004183 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 351745004184 putative rRNA binding site [nucleotide binding]; other site 351745004185 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 351745004186 Predicted membrane protein [Function unknown]; Region: COG2860 351745004187 UPF0126 domain; Region: UPF0126; pfam03458 351745004188 UPF0126 domain; Region: UPF0126; pfam03458 351745004189 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 351745004190 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 351745004191 dimer interface [polypeptide binding]; other site 351745004192 catalytic triad [active] 351745004193 peroxidatic and resolving cysteines [active] 351745004194 mechanosensitive channel MscS; Provisional; Region: PRK10334 351745004195 Conserved TM helix; Region: TM_helix; pfam05552 351745004196 Mechanosensitive ion channel; Region: MS_channel; pfam00924 351745004197 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 351745004198 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 351745004199 ligand binding site [chemical binding]; other site 351745004200 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 351745004201 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 351745004202 tetramer interface [polypeptide binding]; other site 351745004203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745004204 catalytic residue [active] 351745004205 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 351745004206 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745004207 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745004208 metal binding site [ion binding]; metal-binding site 351745004209 active site 351745004210 I-site; other site 351745004211 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 351745004212 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 351745004213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 351745004214 Coenzyme A binding pocket [chemical binding]; other site 351745004215 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 351745004216 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 351745004217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745004218 Coenzyme A binding pocket [chemical binding]; other site 351745004219 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 351745004220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745004221 Coenzyme A binding pocket [chemical binding]; other site 351745004222 Pirin-related protein [General function prediction only]; Region: COG1741 351745004223 Pirin; Region: Pirin; pfam02678 351745004224 Predicted membrane protein [Function unknown]; Region: COG2259 351745004225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745004226 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 351745004227 The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which regulates expression of the heme uptake receptor HupA; contains the type 2 periplasmic binding fold; Region: PBP2_HupR; cd08431 351745004228 putative dimerization interface [polypeptide binding]; other site 351745004229 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 351745004230 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 351745004231 active site 351745004232 metal binding site [ion binding]; metal-binding site 351745004233 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 351745004234 Domain of unknown function DUF21; Region: DUF21; pfam01595 351745004235 FOG: CBS domain [General function prediction only]; Region: COG0517 351745004236 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 351745004237 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 351745004238 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351745004239 FeS/SAM binding site; other site 351745004240 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 351745004241 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 351745004242 binding surface 351745004243 TPR motif; other site 351745004244 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 351745004245 TPR motif; other site 351745004246 binding surface 351745004247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 351745004248 binding surface 351745004249 TPR motif; other site 351745004250 cytoskeletal protein RodZ; Provisional; Region: PRK10856 351745004251 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 351745004252 non-specific DNA binding site [nucleotide binding]; other site 351745004253 salt bridge; other site 351745004254 sequence-specific DNA binding site [nucleotide binding]; other site 351745004255 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 351745004256 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 351745004257 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 351745004258 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 351745004259 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 351745004260 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 351745004261 dimer interface [polypeptide binding]; other site 351745004262 motif 1; other site 351745004263 active site 351745004264 motif 2; other site 351745004265 motif 3; other site 351745004266 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 351745004267 anticodon binding site; other site 351745004268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 351745004269 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 351745004270 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 351745004271 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 351745004272 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 351745004273 active site 351745004274 Trp docking motif [polypeptide binding]; other site 351745004275 GTP-binding protein Der; Reviewed; Region: PRK00093 351745004276 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 351745004277 G1 box; other site 351745004278 GTP/Mg2+ binding site [chemical binding]; other site 351745004279 Switch I region; other site 351745004280 G2 box; other site 351745004281 Switch II region; other site 351745004282 G3 box; other site 351745004283 G4 box; other site 351745004284 G5 box; other site 351745004285 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 351745004286 G1 box; other site 351745004287 GTP/Mg2+ binding site [chemical binding]; other site 351745004288 Switch I region; other site 351745004289 G2 box; other site 351745004290 G3 box; other site 351745004291 Switch II region; other site 351745004292 G4 box; other site 351745004293 G5 box; other site 351745004294 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 351745004295 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 351745004296 generic binding surface II; other site 351745004297 generic binding surface I; other site 351745004298 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 351745004299 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 351745004300 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 351745004301 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 351745004302 active site 351745004303 GMP synthase; Reviewed; Region: guaA; PRK00074 351745004304 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 351745004305 AMP/PPi binding site [chemical binding]; other site 351745004306 candidate oxyanion hole; other site 351745004307 catalytic triad [active] 351745004308 potential glutamine specificity residues [chemical binding]; other site 351745004309 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 351745004310 ATP Binding subdomain [chemical binding]; other site 351745004311 Ligand Binding sites [chemical binding]; other site 351745004312 Dimerization subdomain; other site 351745004313 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 351745004314 nucleoside/Zn binding site; other site 351745004315 dimer interface [polypeptide binding]; other site 351745004316 catalytic motif [active] 351745004317 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 351745004318 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 351745004319 substrate binding pocket [chemical binding]; other site 351745004320 membrane-bound complex binding site; other site 351745004321 hinge residues; other site 351745004322 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 351745004323 N-acetyl-D-glucosamine binding site [chemical binding]; other site 351745004324 catalytic residue [active] 351745004325 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 351745004326 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 351745004327 dimerization interface [polypeptide binding]; other site 351745004328 ATP binding site [chemical binding]; other site 351745004329 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 351745004330 dimerization interface [polypeptide binding]; other site 351745004331 ATP binding site [chemical binding]; other site 351745004332 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 351745004333 putative active site [active] 351745004334 catalytic triad [active] 351745004335 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 351745004336 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 351745004337 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 351745004338 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 351745004339 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 351745004340 HAMP domain; Region: HAMP; pfam00672 351745004341 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745004342 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745004343 dimer interface [polypeptide binding]; other site 351745004344 putative CheW interface [polypeptide binding]; other site 351745004345 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 351745004346 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 351745004347 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 351745004348 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745004349 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 351745004350 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 351745004351 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 351745004352 rhombotail lipoprotein; Region: rhombo_lipo; TIGR04179 351745004353 Protein of unknown function (DUF2947); Region: DUF2947; pfam11163 351745004354 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 351745004355 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 351745004356 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 351745004357 NAD(P) binding site [chemical binding]; other site 351745004358 homodimer interface [polypeptide binding]; other site 351745004359 substrate binding site [chemical binding]; other site 351745004360 active site 351745004361 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 351745004362 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 351745004363 inhibitor-cofactor binding pocket; inhibition site 351745004364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745004365 catalytic residue [active] 351745004366 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 351745004367 ligand binding site; other site 351745004368 tetramer interface; other site 351745004369 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 351745004370 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 351745004371 pseudaminic acid synthase; Region: PseI; TIGR03586 351745004372 NeuB family; Region: NeuB; pfam03102 351745004373 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 351745004374 NeuB binding interface [polypeptide binding]; other site 351745004375 putative substrate binding site [chemical binding]; other site 351745004376 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 351745004377 Phosphopantetheine attachment site; Region: PP-binding; cl09936 351745004378 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 351745004379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 351745004380 NAD(P) binding site [chemical binding]; other site 351745004381 active site 351745004382 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 351745004383 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 351745004384 acyl-activating enzyme (AAE) consensus motif; other site 351745004385 AMP binding site [chemical binding]; other site 351745004386 active site 351745004387 CoA binding site [chemical binding]; other site 351745004388 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 351745004389 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 351745004390 NAD(P) binding site [chemical binding]; other site 351745004391 catalytic residues [active] 351745004392 LicD family; Region: LicD; pfam04991 351745004393 magnesium protoporphyrin O-methyltransferase; Region: BchM-ChlM; TIGR02021 351745004394 Methyltransferase domain; Region: Methyltransf_12; pfam08242 351745004395 S-adenosylmethionine binding site [chemical binding]; other site 351745004396 Winged helix-turn helix; Region: HTH_29; pfam13551 351745004397 Homeodomain-like domain; Region: HTH_32; pfam13565 351745004398 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 351745004399 Integrase core domain; Region: rve; pfam00665 351745004400 Integrase core domain; Region: rve_3; pfam13683 351745004401 Transposase; Region: HTH_Tnp_1; cl17663 351745004402 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 351745004403 Transposase [DNA replication, recombination, and repair]; Region: COG5421 351745004404 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 351745004405 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 351745004406 active site 351745004407 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 351745004408 LPP20 lipoprotein; Region: LPP20; pfam02169 351745004409 FlgN protein; Region: FlgN; pfam05130 351745004410 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 351745004411 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 351745004412 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 351745004413 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 351745004414 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 351745004415 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 351745004416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745004417 active site 351745004418 phosphorylation site [posttranslational modification] 351745004419 intermolecular recognition site; other site 351745004420 dimerization interface [polypeptide binding]; other site 351745004421 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 351745004422 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 351745004423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745004424 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12625 351745004425 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 351745004426 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12631 351745004427 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 351745004428 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 351745004429 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 351745004430 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 351745004431 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 351745004432 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 351745004433 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 351745004434 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 351745004435 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 351745004436 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 351745004437 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 351745004438 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 351745004439 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 351745004440 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 351745004441 Flagellar L-ring protein; Region: FlgH; pfam02107 351745004442 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 351745004443 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 351745004444 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 351745004445 flagellar rod assembly protein/muramidase FlgJ; Region: flagell_FlgJ; TIGR02541 351745004446 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 351745004447 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08871 351745004448 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 351745004449 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 351745004450 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 351745004451 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 351745004452 flagellin; Provisional; Region: PRK12802 351745004453 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 351745004454 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 351745004455 flagellin; Provisional; Region: PRK12802 351745004456 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 351745004457 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 351745004458 FlaG protein; Region: FlaG; pfam03646 351745004459 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 351745004460 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 351745004461 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 351745004462 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 351745004463 flagellar protein FliS; Validated; Region: fliS; PRK05685 351745004464 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 351745004465 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 351745004466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745004467 Walker A motif; other site 351745004468 ATP binding site [chemical binding]; other site 351745004469 Walker B motif; other site 351745004470 arginine finger; other site 351745004471 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 351745004472 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 351745004473 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745004474 putative active site [active] 351745004475 heme pocket [chemical binding]; other site 351745004476 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 351745004477 dimer interface [polypeptide binding]; other site 351745004478 phosphorylation site [posttranslational modification] 351745004479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745004480 ATP binding site [chemical binding]; other site 351745004481 Mg2+ binding site [ion binding]; other site 351745004482 G-X-G motif; other site 351745004483 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 351745004484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745004485 active site 351745004486 phosphorylation site [posttranslational modification] 351745004487 intermolecular recognition site; other site 351745004488 dimerization interface [polypeptide binding]; other site 351745004489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745004490 Walker A motif; other site 351745004491 ATP binding site [chemical binding]; other site 351745004492 Walker B motif; other site 351745004493 arginine finger; other site 351745004494 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 351745004495 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 351745004496 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 351745004497 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 351745004498 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 351745004499 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 351745004500 MgtE intracellular N domain; Region: MgtE_N; smart00924 351745004501 FliG C-terminal domain; Region: FliG_C; pfam01706 351745004502 flagellar assembly protein H; Validated; Region: fliH; PRK05687 351745004503 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 351745004504 Flagellar assembly protein FliH; Region: FliH; pfam02108 351745004505 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08972 351745004506 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 351745004507 Walker A motif/ATP binding site; other site 351745004508 Walker B motif; other site 351745004509 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 351745004510 Flagellar FliJ protein; Region: FliJ; pfam02050 351745004511 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 351745004512 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696 351745004513 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 351745004514 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 351745004515 flagellar motor switch protein; Validated; Region: fliN; PRK08983 351745004516 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 351745004517 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 351745004518 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 351745004519 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 351745004520 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 351745004521 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 351745004522 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 351745004523 FHIPEP family; Region: FHIPEP; pfam00771 351745004524 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 351745004525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 351745004526 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 351745004527 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 351745004528 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 351745004529 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 351745004530 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 351745004531 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 351745004532 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 351745004533 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 351745004534 DNA binding residues [nucleotide binding] 351745004535 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 351745004536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745004537 active site 351745004538 phosphorylation site [posttranslational modification] 351745004539 intermolecular recognition site; other site 351745004540 dimerization interface [polypeptide binding]; other site 351745004541 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 351745004542 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 351745004543 putative binding surface; other site 351745004544 active site 351745004545 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 351745004546 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 351745004547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745004548 ATP binding site [chemical binding]; other site 351745004549 Mg2+ binding site [ion binding]; other site 351745004550 G-X-G motif; other site 351745004551 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 351745004552 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 351745004553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745004554 active site 351745004555 phosphorylation site [posttranslational modification] 351745004556 intermolecular recognition site; other site 351745004557 CheB methylesterase; Region: CheB_methylest; pfam01339 351745004558 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 351745004559 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 351745004560 P-loop; other site 351745004561 Magnesium ion binding site [ion binding]; other site 351745004562 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 351745004563 Magnesium ion binding site [ion binding]; other site 351745004564 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 351745004565 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 351745004566 putative CheA interaction surface; other site 351745004567 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 351745004568 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 351745004569 VacJ like lipoprotein; Region: VacJ; cl01073 351745004570 Response regulator receiver domain; Region: Response_reg; pfam00072 351745004571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745004572 active site 351745004573 phosphorylation site [posttranslational modification] 351745004574 intermolecular recognition site; other site 351745004575 dimerization interface [polypeptide binding]; other site 351745004576 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 351745004577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745004578 putative substrate translocation pore; other site 351745004579 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 351745004580 transcriptional activator RfaH; Region: RfaH; TIGR01955 351745004581 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 351745004582 heterodimer interface [polypeptide binding]; other site 351745004583 homodimer interface [polypeptide binding]; other site 351745004584 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 351745004585 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 351745004586 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 351745004587 SLBB domain; Region: SLBB; pfam10531 351745004588 SLBB domain; Region: SLBB; pfam10531 351745004589 SLBB domain; Region: SLBB; pfam10531 351745004590 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 351745004591 SLBB domain; Region: SLBB; pfam10531 351745004592 Chain length determinant protein; Region: Wzz; pfam02706 351745004593 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 351745004594 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 351745004595 NAD binding site [chemical binding]; other site 351745004596 substrate binding site [chemical binding]; other site 351745004597 homodimer interface [polypeptide binding]; other site 351745004598 active site 351745004599 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 351745004600 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 351745004601 substrate binding site; other site 351745004602 tetramer interface; other site 351745004603 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 351745004604 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 351745004605 NADP binding site [chemical binding]; other site 351745004606 active site 351745004607 putative substrate binding site [chemical binding]; other site 351745004608 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 351745004609 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 351745004610 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 351745004611 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 351745004612 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 351745004613 inhibitor-cofactor binding pocket; inhibition site 351745004614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745004615 catalytic residue [active] 351745004616 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 351745004617 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 351745004618 trimer interface [polypeptide binding]; other site 351745004619 active site 351745004620 substrate binding site [chemical binding]; other site 351745004621 CoA binding site [chemical binding]; other site 351745004622 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 351745004623 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 351745004624 trimer interface [polypeptide binding]; other site 351745004625 active site 351745004626 substrate binding site [chemical binding]; other site 351745004627 CoA binding site [chemical binding]; other site 351745004628 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 351745004629 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 351745004630 active site 351745004631 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 351745004632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 351745004633 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 351745004634 GIY-YIG motif/motif A; other site 351745004635 putative active site [active] 351745004636 putative metal binding site [ion binding]; other site 351745004637 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 351745004638 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 351745004639 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 351745004640 Mg++ binding site [ion binding]; other site 351745004641 putative catalytic motif [active] 351745004642 substrate binding site [chemical binding]; other site 351745004643 NlpE N-terminal domain; Region: NlpE; pfam04170 351745004644 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 351745004645 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 351745004646 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 351745004647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745004648 ATP binding site [chemical binding]; other site 351745004649 Mg2+ binding site [ion binding]; other site 351745004650 G-X-G motif; other site 351745004651 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 351745004652 GIY-YIG motif/motif A; other site 351745004653 putative active site [active] 351745004654 putative metal binding site [ion binding]; other site 351745004655 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 351745004656 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 351745004657 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 351745004658 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 351745004659 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 351745004660 nucleophile elbow; other site 351745004661 prolyl-tRNA synthetase; Provisional; Region: PRK09194 351745004662 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 351745004663 dimer interface [polypeptide binding]; other site 351745004664 motif 1; other site 351745004665 active site 351745004666 motif 2; other site 351745004667 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 351745004668 putative deacylase active site [active] 351745004669 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 351745004670 active site 351745004671 motif 3; other site 351745004672 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 351745004673 anticodon binding site; other site 351745004674 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 351745004675 putative CoA binding site [chemical binding]; other site 351745004676 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 351745004677 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 351745004678 trimer interface [polypeptide binding]; other site 351745004679 active site 351745004680 substrate binding site [chemical binding]; other site 351745004681 CoA binding site [chemical binding]; other site 351745004682 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 351745004683 homodimer interaction site [polypeptide binding]; other site 351745004684 cofactor binding site; other site 351745004685 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 351745004686 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 351745004687 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 351745004688 active site 351745004689 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 351745004690 active site 351745004691 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 351745004692 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 351745004693 active site 351745004694 Topoisomer_IB_N: N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I and heterodimeric topo I from Leishmania donvanni. Topo I enzymes are divided into: topo type IA; Region: Topoisomer_IB_N; cl02774 351745004695 H-NS histone family; Region: Histone_HNS; pfam00816 351745004696 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 351745004697 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 351745004698 Ligand binding site [chemical binding]; other site 351745004699 Electron transfer flavoprotein domain; Region: ETF; pfam01012 351745004700 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 351745004701 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 351745004702 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 351745004703 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 351745004704 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 351745004705 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 351745004706 active site 351745004707 Zn binding site [ion binding]; other site 351745004708 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 351745004709 thymidine kinase; Provisional; Region: PRK04296 351745004710 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 351745004711 Transglycosylase; Region: Transgly; cl17702 351745004712 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 351745004713 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 351745004714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745004715 active site 351745004716 phosphorylation site [posttranslational modification] 351745004717 intermolecular recognition site; other site 351745004718 dimerization interface [polypeptide binding]; other site 351745004719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745004720 Walker A motif; other site 351745004721 ATP binding site [chemical binding]; other site 351745004722 Walker B motif; other site 351745004723 arginine finger; other site 351745004724 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 351745004725 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 351745004726 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745004727 dimer interface [polypeptide binding]; other site 351745004728 phosphorylation site [posttranslational modification] 351745004729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745004730 ATP binding site [chemical binding]; other site 351745004731 Mg2+ binding site [ion binding]; other site 351745004732 G-X-G motif; other site 351745004733 DctM-like transporters; Region: DctM; pfam06808 351745004734 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 351745004735 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 351745004736 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 351745004737 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 351745004738 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 351745004739 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 351745004740 active site 351745004741 HIGH motif; other site 351745004742 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 351745004743 active site 351745004744 KMSKS motif; other site 351745004745 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 351745004746 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 351745004747 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 351745004748 Walker A/P-loop; other site 351745004749 ATP binding site [chemical binding]; other site 351745004750 Q-loop/lid; other site 351745004751 ABC transporter signature motif; other site 351745004752 Walker B; other site 351745004753 D-loop; other site 351745004754 H-loop/switch region; other site 351745004755 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 351745004756 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 351745004757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 351745004758 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 351745004759 AlkA N-terminal domain; Region: AlkA_N; pfam06029 351745004760 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 351745004761 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 351745004762 minor groove reading motif; other site 351745004763 helix-hairpin-helix signature motif; other site 351745004764 substrate binding pocket [chemical binding]; other site 351745004765 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 351745004766 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 351745004767 DNA binding site [nucleotide binding] 351745004768 active site 351745004769 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 351745004770 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 351745004771 ATP binding site [chemical binding]; other site 351745004772 Mg++ binding site [ion binding]; other site 351745004773 motif III; other site 351745004774 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745004775 nucleotide binding region [chemical binding]; other site 351745004776 ATP-binding site [chemical binding]; other site 351745004777 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 351745004778 active site 351745004779 catalytic residues [active] 351745004780 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 351745004781 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 351745004782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745004783 active site 351745004784 phosphorylation site [posttranslational modification] 351745004785 intermolecular recognition site; other site 351745004786 dimerization interface [polypeptide binding]; other site 351745004787 serine/threonine transporter SstT; Provisional; Region: PRK13628 351745004788 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 351745004789 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 351745004790 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 351745004791 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 351745004792 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 351745004793 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 351745004794 active site 351745004795 Protein of unknown function, DUF479; Region: DUF479; pfam04336 351745004796 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 351745004797 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 351745004798 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 351745004799 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 351745004800 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 351745004801 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 351745004802 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 351745004803 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 351745004804 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 351745004805 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 351745004806 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 351745004807 Protein export membrane protein; Region: SecD_SecF; pfam02355 351745004808 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 351745004809 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 351745004810 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 351745004811 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 351745004812 YaeQ protein; Region: YaeQ; pfam07152 351745004813 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 351745004814 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 351745004815 active site 351745004816 catalytic residues [active] 351745004817 PA_VapT_like: Protease-associated domain containing proteins like VapT from Vibrio metschnikovii strain RH530. This group contains various PA domain-containing proteins similar to V. metschnikovii VapT, including the serine alkaline protease SapSh from...; Region: PA_VapT_like; cd04817 351745004818 PA/subtilisin-like domain interface [polypeptide binding]; other site 351745004819 Subtilase family; Region: Peptidase_S8; pfam00082 351745004820 catalytic residues [active] 351745004821 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 351745004822 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 351745004823 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 351745004824 active site residue [active] 351745004825 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 351745004826 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 351745004827 Protein export membrane protein; Region: SecD_SecF; cl14618 351745004828 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 351745004829 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745004830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 351745004831 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 351745004832 active site 351745004833 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 351745004834 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 351745004835 Na binding site [ion binding]; other site 351745004836 Protein of unknown function (DUF3379); Region: DUF3379; pfam11859 351745004837 RNA polymerase sigma factor; Provisional; Region: PRK12517 351745004838 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 351745004839 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 351745004840 DNA binding residues [nucleotide binding] 351745004841 Oxygen tolerance; Region: BatD; pfam13584 351745004842 von Willebrand factor type A domain; Region: VWA_2; pfam13519 351745004843 metal ion-dependent adhesion site (MIDAS); other site 351745004844 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 351745004845 binding surface 351745004846 TPR motif; other site 351745004847 Tetratricopeptide repeat; Region: TPR_16; pfam13432 351745004848 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 351745004849 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 351745004850 metal ion-dependent adhesion site (MIDAS); other site 351745004851 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 351745004852 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 351745004853 Protein of unknown function DUF58; Region: DUF58; pfam01882 351745004854 MoxR-like ATPases [General function prediction only]; Region: COG0714 351745004855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745004856 Walker A motif; other site 351745004857 ATP binding site [chemical binding]; other site 351745004858 Walker B motif; other site 351745004859 arginine finger; other site 351745004860 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 351745004861 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 351745004862 dimer interface [polypeptide binding]; other site 351745004863 active site 351745004864 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 351745004865 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 351745004866 substrate binding site [chemical binding]; other site 351745004867 oxyanion hole (OAH) forming residues; other site 351745004868 trimer interface [polypeptide binding]; other site 351745004869 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 351745004870 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 351745004871 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 351745004872 Two component regulator propeller; Region: Reg_prop; pfam07494 351745004873 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 351745004874 PAS fold; Region: PAS_3; pfam08447 351745004875 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745004876 PAS domain; Region: PAS_9; pfam13426 351745004877 putative active site [active] 351745004878 heme pocket [chemical binding]; other site 351745004879 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745004880 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745004881 metal binding site [ion binding]; metal-binding site 351745004882 active site 351745004883 I-site; other site 351745004884 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745004885 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 351745004886 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 351745004887 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 351745004888 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 351745004889 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 351745004890 catalytic core [active] 351745004891 hypothetical protein; Provisional; Region: PRK04946 351745004892 Smr domain; Region: Smr; pfam01713 351745004893 HemK family putative methylases; Region: hemK_fam; TIGR00536 351745004894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745004895 S-adenosylmethionine binding site [chemical binding]; other site 351745004896 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 351745004897 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 351745004898 Tetramer interface [polypeptide binding]; other site 351745004899 active site 351745004900 FMN-binding site [chemical binding]; other site 351745004901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745004902 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 351745004903 putative substrate translocation pore; other site 351745004904 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 351745004905 YfcL protein; Region: YfcL; pfam08891 351745004906 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 351745004907 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 351745004908 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 351745004909 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 351745004910 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 351745004911 dimer interface [polypeptide binding]; other site 351745004912 active site 351745004913 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 351745004914 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 351745004915 ligand binding site [chemical binding]; other site 351745004916 NAD binding site [chemical binding]; other site 351745004917 catalytic site [active] 351745004918 homodimer interface [polypeptide binding]; other site 351745004919 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 351745004920 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 351745004921 FimV N-terminal domain; Region: FimV_core; TIGR03505 351745004922 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 351745004923 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 351745004924 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 351745004925 dimerization interface 3.5A [polypeptide binding]; other site 351745004926 active site 351745004927 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 351745004928 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 351745004929 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 351745004930 cell division protein DedD; Provisional; Region: PRK11633 351745004931 Sporulation related domain; Region: SPOR; pfam05036 351745004932 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 351745004933 Colicin V production protein; Region: Colicin_V; cl00567 351745004934 amidophosphoribosyltransferase; Provisional; Region: PRK09246 351745004935 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 351745004936 active site 351745004937 tetramer interface [polypeptide binding]; other site 351745004938 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 351745004939 active site 351745004940 DNA topoisomerase III; Provisional; Region: PRK07726 351745004941 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 351745004942 active site 351745004943 putative interdomain interaction site [polypeptide binding]; other site 351745004944 putative metal-binding site [ion binding]; other site 351745004945 putative nucleotide binding site [chemical binding]; other site 351745004946 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 351745004947 domain I; other site 351745004948 DNA binding groove [nucleotide binding] 351745004949 phosphate binding site [ion binding]; other site 351745004950 domain II; other site 351745004951 domain III; other site 351745004952 nucleotide binding site [chemical binding]; other site 351745004953 catalytic site [active] 351745004954 domain IV; other site 351745004955 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 351745004956 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 351745004957 eyelet of channel; other site 351745004958 trimer interface [polypeptide binding]; other site 351745004959 GAF domain; Region: GAF_2; pfam13185 351745004960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745004961 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 351745004962 Walker A motif; other site 351745004963 ATP binding site [chemical binding]; other site 351745004964 Walker B motif; other site 351745004965 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 351745004966 L-aspartate oxidase; Provisional; Region: PRK06175 351745004967 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 351745004968 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 351745004969 active sites [active] 351745004970 tetramer interface [polypeptide binding]; other site 351745004971 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 351745004972 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 351745004973 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 351745004974 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 351745004975 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 351745004976 XdhC Rossmann domain; Region: XdhC_C; pfam13478 351745004977 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 351745004978 Ligand binding site; other site 351745004979 metal-binding site 351745004980 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 351745004981 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 351745004982 catalytic loop [active] 351745004983 iron binding site [ion binding]; other site 351745004984 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 351745004985 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 351745004986 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 351745004987 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 351745004988 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 351745004989 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 351745004990 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745004991 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745004992 dimer interface [polypeptide binding]; other site 351745004993 putative CheW interface [polypeptide binding]; other site 351745004994 SnoaL-like domain; Region: SnoaL_2; pfam12680 351745004995 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 351745004996 putative catalytic site [active] 351745004997 putative phosphate binding site [ion binding]; other site 351745004998 active site 351745004999 metal binding site A [ion binding]; metal-binding site 351745005000 DNA binding site [nucleotide binding] 351745005001 putative AP binding site [nucleotide binding]; other site 351745005002 putative metal binding site B [ion binding]; other site 351745005003 YciI-like protein; Reviewed; Region: PRK11370 351745005004 intracellular septation protein A; Reviewed; Region: PRK00259 351745005005 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 351745005006 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 351745005007 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 351745005008 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 351745005009 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745005010 N-terminal plug; other site 351745005011 ligand-binding site [chemical binding]; other site 351745005012 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 351745005013 IucA / IucC family; Region: IucA_IucC; pfam04183 351745005014 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 351745005015 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 351745005016 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 351745005017 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 351745005018 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 351745005019 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 351745005020 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 351745005021 substrate binding site [chemical binding]; other site 351745005022 active site 351745005023 catalytic residues [active] 351745005024 heterodimer interface [polypeptide binding]; other site 351745005025 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 351745005026 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 351745005027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745005028 catalytic residue [active] 351745005029 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 351745005030 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 351745005031 active site 351745005032 ribulose/triose binding site [chemical binding]; other site 351745005033 phosphate binding site [ion binding]; other site 351745005034 substrate (anthranilate) binding pocket [chemical binding]; other site 351745005035 product (indole) binding pocket [chemical binding]; other site 351745005036 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 351745005037 active site 351745005038 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 351745005039 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 351745005040 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 351745005041 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 351745005042 glutamine binding [chemical binding]; other site 351745005043 catalytic triad [active] 351745005044 anthranilate synthase component I; Provisional; Region: PRK13564 351745005045 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 351745005046 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 351745005047 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 351745005048 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 351745005049 active site 351745005050 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 351745005051 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 351745005052 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 351745005053 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 351745005054 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 351745005055 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 351745005056 RNA binding surface [nucleotide binding]; other site 351745005057 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 351745005058 probable active site [active] 351745005059 BNR repeat-like domain; Region: BNR_2; pfam13088 351745005060 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 351745005061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 351745005062 NAD(P) binding site [chemical binding]; other site 351745005063 active site 351745005064 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 351745005065 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 351745005066 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 351745005067 putative inner membrane peptidase; Provisional; Region: PRK11778 351745005068 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 351745005069 tandem repeat interface [polypeptide binding]; other site 351745005070 oligomer interface [polypeptide binding]; other site 351745005071 active site residues [active] 351745005072 Protein of unknown function (DUF3083); Region: DUF3083; pfam11281 351745005073 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 351745005074 active site 351745005075 catalytic triad [active] 351745005076 oxyanion hole [active] 351745005077 switch loop; other site 351745005078 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 351745005079 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 351745005080 Walker A/P-loop; other site 351745005081 ATP binding site [chemical binding]; other site 351745005082 Q-loop/lid; other site 351745005083 ABC transporter signature motif; other site 351745005084 Walker B; other site 351745005085 D-loop; other site 351745005086 H-loop/switch region; other site 351745005087 FtsX-like permease family; Region: FtsX; pfam02687 351745005088 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 351745005089 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 351745005090 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 351745005091 putative NAD(P) binding site [chemical binding]; other site 351745005092 putative active site [active] 351745005093 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase; Provisional; Region: folX; PRK11245 351745005094 active site 351745005095 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 351745005096 Domain of unknown function DUF20; Region: UPF0118; pfam01594 351745005097 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 351745005098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745005099 S-adenosylmethionine binding site [chemical binding]; other site 351745005100 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 351745005101 Transposase [DNA replication, recombination, and repair]; Region: COG5421 351745005102 phosphate acetyltransferase; Reviewed; Region: PRK05632 351745005103 DRTGG domain; Region: DRTGG; pfam07085 351745005104 phosphate acetyltransferase; Region: pta; TIGR00651 351745005105 propionate/acetate kinase; Provisional; Region: PRK12379 351745005106 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 351745005107 Protein of unknown function, DUF412; Region: DUF412; pfam04217 351745005108 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 351745005109 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351745005110 FeS/SAM binding site; other site 351745005111 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 351745005112 Pyruvate formate lyase 1; Region: PFL1; cd01678 351745005113 coenzyme A binding site [chemical binding]; other site 351745005114 active site 351745005115 catalytic residues [active] 351745005116 glycine loop; other site 351745005117 Protein of unknown function (DUF3360); Region: DUF3360; pfam11840 351745005118 formate transporter FocA; Region: formate_focA; TIGR04060 351745005119 FOG: CBS domain [General function prediction only]; Region: COG0517 351745005120 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 351745005121 CBS domain; Region: CBS; pfam00571 351745005122 FOG: CBS domain [General function prediction only]; Region: COG0517 351745005123 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 351745005124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745005125 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 351745005126 putative dimerization interface [polypeptide binding]; other site 351745005127 hypothetical protein; Provisional; Region: PRK11588 351745005128 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 351745005129 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 351745005130 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 351745005131 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 351745005132 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 351745005133 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 351745005134 gating phenylalanine in ion channel; other site 351745005135 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 351745005136 O-methyltransferase; Region: Methyltransf_2; pfam00891 351745005137 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 351745005138 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 351745005139 dimer interface [polypeptide binding]; other site 351745005140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745005141 catalytic residue [active] 351745005142 RDD family; Region: RDD; pfam06271 351745005143 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 351745005144 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 351745005145 active site 351745005146 putative sulfate transport protein CysZ; Validated; Region: PRK04949 351745005147 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 351745005148 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 351745005149 Walker A/P-loop; other site 351745005150 ATP binding site [chemical binding]; other site 351745005151 Q-loop/lid; other site 351745005152 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 351745005153 ABC transporter signature motif; other site 351745005154 Walker B; other site 351745005155 D-loop; other site 351745005156 H-loop/switch region; other site 351745005157 cell division protein ZipA; Provisional; Region: PRK03427 351745005158 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 351745005159 FtsZ protein binding site [polypeptide binding]; other site 351745005160 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 351745005161 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 351745005162 nucleotide binding pocket [chemical binding]; other site 351745005163 K-X-D-G motif; other site 351745005164 catalytic site [active] 351745005165 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 351745005166 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 351745005167 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 351745005168 Dimer interface [polypeptide binding]; other site 351745005169 BRCT sequence motif; other site 351745005170 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 351745005171 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 351745005172 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 351745005173 Zn2+ binding site [ion binding]; other site 351745005174 Mg2+ binding site [ion binding]; other site 351745005175 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 351745005176 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 351745005177 putative NAD(P) binding site [chemical binding]; other site 351745005178 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 351745005179 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 351745005180 catalytic residues [active] 351745005181 hinge region; other site 351745005182 alpha helical domain; other site 351745005183 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 351745005184 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 351745005185 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 351745005186 Na binding site [ion binding]; other site 351745005187 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 351745005188 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 351745005189 ligand binding site [chemical binding]; other site 351745005190 flexible hinge region; other site 351745005191 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 351745005192 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 351745005193 metal binding triad; other site 351745005194 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 351745005195 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 351745005196 active site 351745005197 catalytic site [active] 351745005198 substrate binding site [chemical binding]; other site 351745005199 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 351745005200 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 351745005201 dimer interface [polypeptide binding]; other site 351745005202 active site 351745005203 CoA binding pocket [chemical binding]; other site 351745005204 Transcriptional regulators [Transcription]; Region: GntR; COG1802 351745005205 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 351745005206 DNA-binding site [nucleotide binding]; DNA binding site 351745005207 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 351745005208 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 351745005209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351745005210 active site 351745005211 motif I; other site 351745005212 motif II; other site 351745005213 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 351745005214 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 351745005215 GSH binding site [chemical binding]; other site 351745005216 catalytic residues [active] 351745005217 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 351745005218 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351745005219 ATP binding site [chemical binding]; other site 351745005220 putative Mg++ binding site [ion binding]; other site 351745005221 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745005222 nucleotide binding region [chemical binding]; other site 351745005223 ATP-binding site [chemical binding]; other site 351745005224 Double zinc ribbon; Region: DZR; pfam12773 351745005225 acetyl-CoA synthetase; Provisional; Region: PRK00174 351745005226 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 351745005227 active site 351745005228 CoA binding site [chemical binding]; other site 351745005229 acyl-activating enzyme (AAE) consensus motif; other site 351745005230 AMP binding site [chemical binding]; other site 351745005231 acetate binding site [chemical binding]; other site 351745005232 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 351745005233 Na binding site [ion binding]; other site 351745005234 PAS domain; Region: PAS; smart00091 351745005235 PAS fold; Region: PAS_7; pfam12860 351745005236 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 351745005237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745005238 dimer interface [polypeptide binding]; other site 351745005239 phosphorylation site [posttranslational modification] 351745005240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745005241 ATP binding site [chemical binding]; other site 351745005242 Mg2+ binding site [ion binding]; other site 351745005243 G-X-G motif; other site 351745005244 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 351745005245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745005246 active site 351745005247 phosphorylation site [posttranslational modification] 351745005248 intermolecular recognition site; other site 351745005249 dimerization interface [polypeptide binding]; other site 351745005250 Cache domain; Region: Cache_2; cl07034 351745005251 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745005252 dimerization interface [polypeptide binding]; other site 351745005253 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745005254 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745005255 dimer interface [polypeptide binding]; other site 351745005256 putative CheW interface [polypeptide binding]; other site 351745005257 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 351745005258 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 351745005259 inhibitor-cofactor binding pocket; inhibition site 351745005260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745005261 catalytic residue [active] 351745005262 biotin synthase; Provisional; Region: PRK15108 351745005263 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351745005264 FeS/SAM binding site; other site 351745005265 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 351745005266 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 351745005267 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 351745005268 substrate-cofactor binding pocket; other site 351745005269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745005270 catalytic residue [active] 351745005271 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 351745005272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745005273 S-adenosylmethionine binding site [chemical binding]; other site 351745005274 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 351745005275 AAA domain; Region: AAA_26; pfam13500 351745005276 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 351745005277 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745005278 N-terminal plug; other site 351745005279 ligand-binding site [chemical binding]; other site 351745005280 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 351745005281 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 351745005282 Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919 351745005283 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 351745005284 Protein of unknown function (DUF3187); Region: DUF3187; pfam11383 351745005285 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 351745005286 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 351745005287 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 351745005288 active site pocket [active] 351745005289 oxyanion hole [active] 351745005290 catalytic triad [active] 351745005291 active site nucleophile [active] 351745005292 heat shock protein HtpX; Provisional; Region: PRK05457 351745005293 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 351745005294 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 351745005295 DNA binding residues [nucleotide binding] 351745005296 dimerization interface [polypeptide binding]; other site 351745005297 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 351745005298 hypothetical protein; Provisional; Region: PRK11770 351745005299 Domain of unknown function (DUF307); Region: DUF307; pfam03733 351745005300 Domain of unknown function (DUF307); Region: DUF307; pfam03733 351745005301 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 351745005302 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 351745005303 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 351745005304 nudix motif; other site 351745005305 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 351745005306 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 351745005307 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 351745005308 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 351745005309 active site 351745005310 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 351745005311 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 351745005312 active site 351745005313 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 351745005314 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 351745005315 RNA polymerase sigma factor; Provisional; Region: PRK11924 351745005316 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 351745005317 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 351745005318 DNA binding residues [nucleotide binding] 351745005319 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 351745005320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745005321 S-adenosylmethionine binding site [chemical binding]; other site 351745005322 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 351745005323 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 351745005324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745005325 active site 351745005326 phosphorylation site [posttranslational modification] 351745005327 intermolecular recognition site; other site 351745005328 dimerization interface [polypeptide binding]; other site 351745005329 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 351745005330 Transglycosylase SLT domain; Region: SLT_2; pfam13406 351745005331 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 351745005332 N-acetyl-D-glucosamine binding site [chemical binding]; other site 351745005333 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 351745005334 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 351745005335 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 351745005336 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 351745005337 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 351745005338 active site 351745005339 Zn binding site [ion binding]; other site 351745005340 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 351745005341 Protein of unknown function (DUF3389); Region: DUF3389; pfam11869 351745005342 putative hydrolase; Provisional; Region: PRK11460 351745005343 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 351745005344 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 351745005345 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 351745005346 active site 351745005347 metal binding site [ion binding]; metal-binding site 351745005348 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 351745005349 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 351745005350 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 351745005351 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 351745005352 FMN binding site [chemical binding]; other site 351745005353 active site 351745005354 catalytic residues [active] 351745005355 substrate binding site [chemical binding]; other site 351745005356 hypothetical protein; Provisional; Region: PRK05409 351745005357 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 351745005358 hypothetical protein; Provisional; Region: PRK10527 351745005359 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 351745005360 active site 351745005361 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14949 351745005362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745005363 Walker A motif; other site 351745005364 ATP binding site [chemical binding]; other site 351745005365 Walker B motif; other site 351745005366 DNA polymerase III subunit delta'; Validated; Region: PRK08485 351745005367 arginine finger; other site 351745005368 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 351745005369 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 351745005370 hypothetical protein; Validated; Region: PRK00153 351745005371 recombination protein RecR; Reviewed; Region: recR; PRK00076 351745005372 RecR protein; Region: RecR; pfam02132 351745005373 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 351745005374 putative active site [active] 351745005375 putative metal-binding site [ion binding]; other site 351745005376 tetramer interface [polypeptide binding]; other site 351745005377 heat shock protein 90; Provisional; Region: PRK05218 351745005378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745005379 ATP binding site [chemical binding]; other site 351745005380 Mg2+ binding site [ion binding]; other site 351745005381 G-X-G motif; other site 351745005382 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 351745005383 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 351745005384 adenylate kinase; Reviewed; Region: adk; PRK00279 351745005385 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 351745005386 AMP-binding site [chemical binding]; other site 351745005387 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 351745005388 ferrochelatase; Reviewed; Region: hemH; PRK00035 351745005389 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 351745005390 C-terminal domain interface [polypeptide binding]; other site 351745005391 active site 351745005392 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 351745005393 active site 351745005394 N-terminal domain interface [polypeptide binding]; other site 351745005395 inosine/guanosine kinase; Provisional; Region: PRK15074 351745005396 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 351745005397 substrate binding site [chemical binding]; other site 351745005398 ATP binding site [chemical binding]; other site 351745005399 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 351745005400 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 351745005401 homodimer interface [polypeptide binding]; other site 351745005402 NAD binding pocket [chemical binding]; other site 351745005403 ATP binding pocket [chemical binding]; other site 351745005404 Mg binding site [ion binding]; other site 351745005405 active-site loop [active] 351745005406 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745005407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745005408 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 351745005409 dimerization interface [polypeptide binding]; other site 351745005410 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 351745005411 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 351745005412 active site 351745005413 FMN binding site [chemical binding]; other site 351745005414 substrate binding site [chemical binding]; other site 351745005415 homotetramer interface [polypeptide binding]; other site 351745005416 catalytic residue [active] 351745005417 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 351745005418 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 351745005419 Sulfatase; Region: Sulfatase; cl17466 351745005420 hypothetical protein; Provisional; Region: PRK13689 351745005421 Nucleoid-associated protein [General function prediction only]; Region: COG3081 351745005422 nucleoid-associated protein NdpA; Validated; Region: PRK00378 351745005423 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 351745005424 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 351745005425 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 351745005426 Peptidase family M23; Region: Peptidase_M23; pfam01551 351745005427 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 351745005428 putative metal binding site [ion binding]; other site 351745005429 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 351745005430 Ion transport protein; Region: Ion_trans; pfam00520 351745005431 Ion channel; Region: Ion_trans_2; pfam07885 351745005432 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 351745005433 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 351745005434 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 351745005435 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 351745005436 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 351745005437 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 351745005438 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 351745005439 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745005440 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 351745005441 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 351745005442 dimer interface [polypeptide binding]; other site 351745005443 active site 351745005444 citrylCoA binding site [chemical binding]; other site 351745005445 NADH binding [chemical binding]; other site 351745005446 cationic pore residues; other site 351745005447 oxalacetate/citrate binding site [chemical binding]; other site 351745005448 coenzyme A binding site [chemical binding]; other site 351745005449 catalytic triad [active] 351745005450 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 351745005451 Iron-sulfur protein interface; other site 351745005452 proximal quinone binding site [chemical binding]; other site 351745005453 SdhD (CybS) interface [polypeptide binding]; other site 351745005454 proximal heme binding site [chemical binding]; other site 351745005455 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 351745005456 SdhC subunit interface [polypeptide binding]; other site 351745005457 proximal heme binding site [chemical binding]; other site 351745005458 cardiolipin binding site; other site 351745005459 Iron-sulfur protein interface; other site 351745005460 proximal quinone binding site [chemical binding]; other site 351745005461 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 351745005462 L-aspartate oxidase; Provisional; Region: PRK06175 351745005463 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 351745005464 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 351745005465 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 351745005466 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 351745005467 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 351745005468 TPP-binding site [chemical binding]; other site 351745005469 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 351745005470 PYR/PP interface [polypeptide binding]; other site 351745005471 dimer interface [polypeptide binding]; other site 351745005472 TPP binding site [chemical binding]; other site 351745005473 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 351745005474 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 351745005475 E3 interaction surface; other site 351745005476 lipoyl attachment site [posttranslational modification]; other site 351745005477 e3 binding domain; Region: E3_binding; pfam02817 351745005478 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 351745005479 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 351745005480 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 351745005481 CoA-ligase; Region: Ligase_CoA; pfam00549 351745005482 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 351745005483 CoA binding domain; Region: CoA_binding; pfam02629 351745005484 CoA-ligase; Region: Ligase_CoA; pfam00549 351745005485 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 351745005486 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 351745005487 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 351745005488 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 351745005489 ferric uptake regulator; Provisional; Region: fur; PRK09462 351745005490 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 351745005491 metal binding site 2 [ion binding]; metal-binding site 351745005492 putative DNA binding helix; other site 351745005493 metal binding site 1 [ion binding]; metal-binding site 351745005494 dimer interface [polypeptide binding]; other site 351745005495 structural Zn2+ binding site [ion binding]; other site 351745005496 NAD-dependent deacetylase; Provisional; Region: PRK00481 351745005497 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 351745005498 NAD+ binding site [chemical binding]; other site 351745005499 substrate binding site [chemical binding]; other site 351745005500 Zn binding site [ion binding]; other site 351745005501 AAA domain; Region: AAA_33; pfam13671 351745005502 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 351745005503 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 351745005504 Cl binding site [ion binding]; other site 351745005505 oligomer interface [polypeptide binding]; other site 351745005506 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 351745005507 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 351745005508 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 351745005509 Zn2+ binding site [ion binding]; other site 351745005510 Mg2+ binding site [ion binding]; other site 351745005511 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 351745005512 sensor protein PhoQ; Provisional; Region: PRK10815 351745005513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745005514 ATP binding site [chemical binding]; other site 351745005515 Mg2+ binding site [ion binding]; other site 351745005516 G-X-G motif; other site 351745005517 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 351745005518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745005519 active site 351745005520 phosphorylation site [posttranslational modification] 351745005521 intermolecular recognition site; other site 351745005522 dimerization interface [polypeptide binding]; other site 351745005523 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745005524 DNA binding site [nucleotide binding] 351745005525 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 351745005526 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 351745005527 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 351745005528 succinylarginine dihydrolase; Provisional; Region: PRK13281 351745005529 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 351745005530 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 351745005531 active site 351745005532 interdomain interaction site; other site 351745005533 putative metal-binding site [ion binding]; other site 351745005534 nucleotide binding site [chemical binding]; other site 351745005535 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 351745005536 domain I; other site 351745005537 DNA binding groove [nucleotide binding] 351745005538 phosphate binding site [ion binding]; other site 351745005539 domain II; other site 351745005540 domain III; other site 351745005541 nucleotide binding site [chemical binding]; other site 351745005542 catalytic site [active] 351745005543 domain IV; other site 351745005544 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 351745005545 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 351745005546 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 351745005547 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 351745005548 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 351745005549 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745005550 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 351745005551 substrate binding site [chemical binding]; other site 351745005552 dimerization interface [polypeptide binding]; other site 351745005553 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 351745005554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745005555 active site 351745005556 phosphorylation site [posttranslational modification] 351745005557 intermolecular recognition site; other site 351745005558 dimerization interface [polypeptide binding]; other site 351745005559 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 351745005560 DNA binding residues [nucleotide binding] 351745005561 dimerization interface [polypeptide binding]; other site 351745005562 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 351745005563 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 351745005564 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 351745005565 PEP synthetase regulatory protein; Provisional; Region: PRK05339 351745005566 phosphoenolpyruvate synthase; Validated; Region: PRK06464 351745005567 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 351745005568 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 351745005569 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 351745005570 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 351745005571 FAD binding domain; Region: FAD_binding_4; pfam01565 351745005572 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 351745005573 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 351745005574 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 351745005575 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 351745005576 MarR family; Region: MarR; pfam01047 351745005577 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 351745005578 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 351745005579 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 351745005580 NAD binding site [chemical binding]; other site 351745005581 Phe binding site; other site 351745005582 Cupin superfamily protein; Region: Cupin_4; pfam08007 351745005583 Cupin-like domain; Region: Cupin_8; pfam13621 351745005584 adenylosuccinate lyase; Provisional; Region: PRK09285 351745005585 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 351745005586 tetramer interface [polypeptide binding]; other site 351745005587 active site 351745005588 putative lysogenization regulator; Reviewed; Region: PRK00218 351745005589 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 351745005590 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 351745005591 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 351745005592 nudix motif; other site 351745005593 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 351745005594 pseudouridine synthase; Region: TIGR00093 351745005595 probable active site [active] 351745005596 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 351745005597 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 351745005598 Uncharacterized conserved protein [Function unknown]; Region: COG2127 351745005599 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 351745005600 Clp amino terminal domain; Region: Clp_N; pfam02861 351745005601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745005602 Walker A motif; other site 351745005603 ATP binding site [chemical binding]; other site 351745005604 Walker B motif; other site 351745005605 arginine finger; other site 351745005606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745005607 Walker A motif; other site 351745005608 ATP binding site [chemical binding]; other site 351745005609 Walker B motif; other site 351745005610 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 351745005611 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 351745005612 rRNA binding site [nucleotide binding]; other site 351745005613 predicted 30S ribosome binding site; other site 351745005614 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 351745005615 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 351745005616 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 351745005617 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 351745005618 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 351745005619 Uncharacterized conserved protein [Function unknown]; Region: COG0327 351745005620 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 351745005621 Predicted permeases [General function prediction only]; Region: COG0679 351745005622 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 351745005623 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 351745005624 active site 351745005625 HIGH motif; other site 351745005626 KMSKS motif; other site 351745005627 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 351745005628 tRNA binding surface [nucleotide binding]; other site 351745005629 anticodon binding site; other site 351745005630 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 351745005631 dimer interface [polypeptide binding]; other site 351745005632 putative tRNA-binding site [nucleotide binding]; other site 351745005633 antiporter inner membrane protein; Provisional; Region: PRK11670 351745005634 Domain of unknown function DUF59; Region: DUF59; cl00941 351745005635 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 351745005636 Walker A motif; other site 351745005637 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 351745005638 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 351745005639 Sugar specificity; other site 351745005640 Pyrimidine base specificity; other site 351745005641 ATP-binding site [chemical binding]; other site 351745005642 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 351745005643 trimer interface [polypeptide binding]; other site 351745005644 active site 351745005645 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 351745005646 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 351745005647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745005648 catalytic residue [active] 351745005649 YceG-like family; Region: YceG; pfam02618 351745005650 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 351745005651 dimerization interface [polypeptide binding]; other site 351745005652 thymidylate kinase; Validated; Region: tmk; PRK00698 351745005653 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 351745005654 TMP-binding site; other site 351745005655 ATP-binding site [chemical binding]; other site 351745005656 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 351745005657 DNA polymerase III subunit delta'; Validated; Region: PRK08485 351745005658 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 351745005659 PilZ domain; Region: PilZ; cl01260 351745005660 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 351745005661 active site 351745005662 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 351745005663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745005664 S-adenosylmethionine binding site [chemical binding]; other site 351745005665 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 351745005666 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 351745005667 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 351745005668 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 351745005669 mce related protein; Region: MCE; pfam02470 351745005670 mce related protein; Region: MCE; pfam02470 351745005671 mce related protein; Region: MCE; pfam02470 351745005672 mce related protein; Region: MCE; pfam02470 351745005673 mce related protein; Region: MCE; pfam02470 351745005674 mce related protein; Region: MCE; pfam02470 351745005675 mce related protein; Region: MCE; pfam02470 351745005676 Paraquat-inducible protein A; Region: PqiA; pfam04403 351745005677 Paraquat-inducible protein A; Region: PqiA; pfam04403 351745005678 YebG protein; Region: YebG; pfam07130 351745005679 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 351745005680 GAF domain; Region: GAF_2; pfam13185 351745005681 ProP expression regulator; Provisional; Region: PRK04950 351745005682 ProQ/FINO family; Region: ProQ; smart00945 351745005683 carboxy-terminal protease; Provisional; Region: PRK11186 351745005684 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 351745005685 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 351745005686 protein binding site [polypeptide binding]; other site 351745005687 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 351745005688 Catalytic dyad [active] 351745005689 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 351745005690 aminopeptidase N; Provisional; Region: pepN; PRK14015 351745005691 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 351745005692 active site 351745005693 Zn binding site [ion binding]; other site 351745005694 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 351745005695 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 351745005696 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 351745005697 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 351745005698 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 351745005699 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 351745005700 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 351745005701 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 351745005702 quinone interaction residues [chemical binding]; other site 351745005703 active site 351745005704 catalytic residues [active] 351745005705 FMN binding site [chemical binding]; other site 351745005706 substrate binding site [chemical binding]; other site 351745005707 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 351745005708 alpha-galactosidase; Provisional; Region: PRK15076 351745005709 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 351745005710 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 351745005711 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 351745005712 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 351745005713 aromatic amino acid transport protein; Region: araaP; TIGR00837 351745005714 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 351745005715 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 351745005716 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 351745005717 metal binding site [ion binding]; metal-binding site 351745005718 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 351745005719 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 351745005720 substrate binding site [chemical binding]; other site 351745005721 glutamase interaction surface [polypeptide binding]; other site 351745005722 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 351745005723 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 351745005724 catalytic residues [active] 351745005725 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 351745005726 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 351745005727 putative active site [active] 351745005728 oxyanion strand; other site 351745005729 catalytic triad [active] 351745005730 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 351745005731 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351745005732 active site 351745005733 motif I; other site 351745005734 motif II; other site 351745005735 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 351745005736 putative active site pocket [active] 351745005737 4-fold oligomerization interface [polypeptide binding]; other site 351745005738 metal binding residues [ion binding]; metal-binding site 351745005739 3-fold/trimer interface [polypeptide binding]; other site 351745005740 histidinol-phosphate aminotransferase; Provisional; Region: PRK04635 351745005741 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 351745005742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745005743 homodimer interface [polypeptide binding]; other site 351745005744 catalytic residue [active] 351745005745 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 351745005746 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 351745005747 NAD binding site [chemical binding]; other site 351745005748 dimerization interface [polypeptide binding]; other site 351745005749 product binding site; other site 351745005750 substrate binding site [chemical binding]; other site 351745005751 zinc binding site [ion binding]; other site 351745005752 catalytic residues [active] 351745005753 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 351745005754 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 351745005755 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 351745005756 Protein of unknown function (DUF938); Region: DUF938; pfam06080 351745005757 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 351745005758 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 351745005759 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745005760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745005761 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 351745005762 putative effector binding pocket; other site 351745005763 putative dimerization interface [polypeptide binding]; other site 351745005764 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 351745005765 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 351745005766 substrate binding site [chemical binding]; other site 351745005767 catalytic Zn binding site [ion binding]; other site 351745005768 NAD binding site [chemical binding]; other site 351745005769 structural Zn binding site [ion binding]; other site 351745005770 dimer interface [polypeptide binding]; other site 351745005771 S-formylglutathione hydrolase; Region: PLN02442 351745005772 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 351745005773 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 351745005774 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 351745005775 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 351745005776 beta-hexosaminidase; Provisional; Region: PRK05337 351745005777 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 351745005778 hypothetical protein; Provisional; Region: PRK04940 351745005779 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 351745005780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745005781 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 351745005782 Coenzyme A binding pocket [chemical binding]; other site 351745005783 Uncharacterized small protein (DUF2158); Region: DUF2158; pfam09926 351745005784 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 351745005785 Putative transposase; Region: Y2_Tnp; pfam04986 351745005786 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 351745005787 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 351745005788 Int/Topo IB signature motif; other site 351745005789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 351745005790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 351745005791 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 351745005792 acylphosphatase; Provisional; Region: PRK14429 351745005793 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 351745005794 transcription-repair coupling factor; Provisional; Region: PRK10689 351745005795 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 351745005796 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351745005797 ATP binding site [chemical binding]; other site 351745005798 putative Mg++ binding site [ion binding]; other site 351745005799 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745005800 nucleotide binding region [chemical binding]; other site 351745005801 ATP-binding site [chemical binding]; other site 351745005802 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 351745005803 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 351745005804 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 351745005805 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 351745005806 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 351745005807 Walker A/P-loop; other site 351745005808 ATP binding site [chemical binding]; other site 351745005809 Q-loop/lid; other site 351745005810 ABC transporter signature motif; other site 351745005811 Walker B; other site 351745005812 D-loop; other site 351745005813 H-loop/switch region; other site 351745005814 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 351745005815 FtsX-like permease family; Region: FtsX; pfam02687 351745005816 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 351745005817 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 351745005818 active site 351745005819 dimerization interface [polypeptide binding]; other site 351745005820 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 351745005821 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 351745005822 serine O-acetyltransferase; Region: cysE; TIGR01172 351745005823 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 351745005824 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 351745005825 trimer interface [polypeptide binding]; other site 351745005826 active site 351745005827 substrate binding site [chemical binding]; other site 351745005828 CoA binding site [chemical binding]; other site 351745005829 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 351745005830 Rrf2 family protein; Region: rrf2_super; TIGR00738 351745005831 cysteine desulfurase; Provisional; Region: PRK14012 351745005832 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 351745005833 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 351745005834 catalytic residue [active] 351745005835 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 351745005836 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 351745005837 trimerization site [polypeptide binding]; other site 351745005838 active site 351745005839 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 351745005840 co-chaperone HscB; Provisional; Region: hscB; PRK05014 351745005841 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 351745005842 HSP70 interaction site [polypeptide binding]; other site 351745005843 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 351745005844 chaperone protein HscA; Provisional; Region: hscA; PRK05183 351745005845 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 351745005846 nucleotide binding site [chemical binding]; other site 351745005847 putative NEF/HSP70 interaction site [polypeptide binding]; other site 351745005848 SBD interface [polypeptide binding]; other site 351745005849 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 351745005850 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 351745005851 catalytic loop [active] 351745005852 iron binding site [ion binding]; other site 351745005853 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 351745005854 ATP-grasp domain; Region: ATP-grasp_4; cl17255 351745005855 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 351745005856 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 351745005857 active site 351745005858 multimer interface [polypeptide binding]; other site 351745005859 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 351745005860 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 351745005861 putative dimer interface [polypeptide binding]; other site 351745005862 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 351745005863 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 351745005864 putative valine binding site [chemical binding]; other site 351745005865 dimer interface [polypeptide binding]; other site 351745005866 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 351745005867 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08979 351745005868 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 351745005869 PYR/PP interface [polypeptide binding]; other site 351745005870 dimer interface [polypeptide binding]; other site 351745005871 TPP binding site [chemical binding]; other site 351745005872 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 351745005873 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 351745005874 TPP-binding site [chemical binding]; other site 351745005875 dimer interface [polypeptide binding]; other site 351745005876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745005877 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 351745005878 putative substrate translocation pore; other site 351745005879 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 351745005880 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 351745005881 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 351745005882 DNA-binding site [nucleotide binding]; DNA binding site 351745005883 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 351745005884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745005885 homodimer interface [polypeptide binding]; other site 351745005886 catalytic residue [active] 351745005887 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 351745005888 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 351745005889 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 351745005890 Sulfate transporter family; Region: Sulfate_transp; pfam00916 351745005891 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 351745005892 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 351745005893 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 351745005894 active site residue [active] 351745005895 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 351745005896 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 351745005897 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 351745005898 Ligand binding site; other site 351745005899 oligomer interface; other site 351745005900 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 351745005901 active site clefts [active] 351745005902 zinc binding site [ion binding]; other site 351745005903 dimer interface [polypeptide binding]; other site 351745005904 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 351745005905 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 351745005906 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 351745005907 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 351745005908 metal binding site [ion binding]; metal-binding site 351745005909 dimer interface [polypeptide binding]; other site 351745005910 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 351745005911 ArsC family; Region: ArsC; pfam03960 351745005912 putative catalytic residues [active] 351745005913 Vibrio chemotaxis protein N terminus; Region: MCP_N; pfam05581 351745005914 Cache domain; Region: Cache_1; pfam02743 351745005915 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745005916 dimerization interface [polypeptide binding]; other site 351745005917 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745005918 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745005919 dimer interface [polypeptide binding]; other site 351745005920 putative CheW interface [polypeptide binding]; other site 351745005921 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 351745005922 Transposase [DNA replication, recombination, and repair]; Region: COG5421 351745005923 PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439 351745005924 HPr interaction site; other site 351745005925 glycerol kinase (GK) interaction site [polypeptide binding]; other site 351745005926 active site 351745005927 phosphorylation site [posttranslational modification] 351745005928 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 351745005929 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 351745005930 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 351745005931 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 351745005932 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 351745005933 dimerization domain swap beta strand [polypeptide binding]; other site 351745005934 regulatory protein interface [polypeptide binding]; other site 351745005935 active site 351745005936 regulatory phosphorylation site [posttranslational modification]; other site 351745005937 Uncharacterized conserved protein [Function unknown]; Region: COG3603 351745005938 Family description; Region: ACT_7; pfam13840 351745005939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 351745005940 Cache domain; Region: Cache_2; cl07034 351745005941 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745005942 dimerization interface [polypeptide binding]; other site 351745005943 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745005944 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745005945 dimer interface [polypeptide binding]; other site 351745005946 putative CheW interface [polypeptide binding]; other site 351745005947 Protein of unknown function (DUF3334); Region: DUF3334; pfam11813 351745005948 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 351745005949 active site 351745005950 catalytic site [active] 351745005951 substrate binding site [chemical binding]; other site 351745005952 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 351745005953 AAA domain; Region: AAA_30; pfam13604 351745005954 Family description; Region: UvrD_C_2; pfam13538 351745005955 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 351745005956 Part of AAA domain; Region: AAA_19; pfam13245 351745005957 Family description; Region: UvrD_C_2; pfam13538 351745005958 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 351745005959 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 351745005960 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 351745005961 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 351745005962 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 351745005963 Protein of unknown function DUF58; Region: DUF58; pfam01882 351745005964 MoxR-like ATPases [General function prediction only]; Region: COG0714 351745005965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745005966 Walker A motif; other site 351745005967 ATP binding site [chemical binding]; other site 351745005968 Walker B motif; other site 351745005969 arginine finger; other site 351745005970 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745005971 lytic murein transglycosylase; Provisional; Region: PRK11619 351745005972 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 351745005973 N-acetyl-D-glucosamine binding site [chemical binding]; other site 351745005974 catalytic residue [active] 351745005975 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 351745005976 DNA recombination protein RmuC; Provisional; Region: PRK10361 351745005977 RmuC family; Region: RmuC; pfam02646 351745005978 TMAO/DMSO reductase; Reviewed; Region: PRK05363 351745005979 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 351745005980 Moco binding site; other site 351745005981 metal coordination site [ion binding]; other site 351745005982 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 351745005983 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 351745005984 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 351745005985 dimer interface [polypeptide binding]; other site 351745005986 active site 351745005987 metal binding site [ion binding]; metal-binding site 351745005988 glutathione binding site [chemical binding]; other site 351745005989 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 351745005990 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 351745005991 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 351745005992 MarR family; Region: MarR; pfam01047 351745005993 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 351745005994 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 351745005995 putative metal dependent hydrolase; Provisional; Region: PRK11598 351745005996 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 351745005997 Sulfatase; Region: Sulfatase; pfam00884 351745005998 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745005999 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745006000 metal binding site [ion binding]; metal-binding site 351745006001 active site 351745006002 I-site; other site 351745006003 universal stress protein UspE; Provisional; Region: PRK11175 351745006004 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 351745006005 Ligand Binding Site [chemical binding]; other site 351745006006 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 351745006007 Ligand Binding Site [chemical binding]; other site 351745006008 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 351745006009 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 351745006010 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 351745006011 TrkA-N domain; Region: TrkA_N; pfam02254 351745006012 Acylphosphatase; Region: Acylphosphatase; pfam00708 351745006013 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 351745006014 HypF finger; Region: zf-HYPF; pfam07503 351745006015 HypF finger; Region: zf-HYPF; pfam07503 351745006016 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 351745006017 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 351745006018 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 351745006019 putative substrate-binding site; other site 351745006020 nickel binding site [ion binding]; other site 351745006021 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 351745006022 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 351745006023 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 351745006024 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 351745006025 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 351745006026 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 351745006027 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 351745006028 catalytic residues [active] 351745006029 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 351745006030 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 351745006031 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 351745006032 ApbE family; Region: ApbE; pfam02424 351745006033 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 351745006034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745006035 active site 351745006036 phosphorylation site [posttranslational modification] 351745006037 intermolecular recognition site; other site 351745006038 dimerization interface [polypeptide binding]; other site 351745006039 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745006040 DNA binding site [nucleotide binding] 351745006041 sensor protein QseC; Provisional; Region: PRK10337 351745006042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745006043 dimer interface [polypeptide binding]; other site 351745006044 phosphorylation site [posttranslational modification] 351745006045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745006046 ATP binding site [chemical binding]; other site 351745006047 Mg2+ binding site [ion binding]; other site 351745006048 G-X-G motif; other site 351745006049 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 351745006050 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 351745006051 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 351745006052 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 351745006053 Ligand binding site; other site 351745006054 DXD motif; other site 351745006055 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 351745006056 active site 351745006057 homodimer interface [polypeptide binding]; other site 351745006058 protease 4; Provisional; Region: PRK10949 351745006059 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 351745006060 tandem repeat interface [polypeptide binding]; other site 351745006061 oligomer interface [polypeptide binding]; other site 351745006062 active site residues [active] 351745006063 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 351745006064 tandem repeat interface [polypeptide binding]; other site 351745006065 oligomer interface [polypeptide binding]; other site 351745006066 active site residues [active] 351745006067 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 351745006068 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 351745006069 active site 351745006070 FMN binding site [chemical binding]; other site 351745006071 2,4-decadienoyl-CoA binding site; other site 351745006072 catalytic residue [active] 351745006073 4Fe-4S cluster binding site [ion binding]; other site 351745006074 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 351745006075 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 351745006076 YCII-related domain; Region: YCII; pfam03795 351745006077 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 351745006078 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 351745006079 catalytic loop [active] 351745006080 iron binding site [ion binding]; other site 351745006081 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 351745006082 dimer interface [polypeptide binding]; other site 351745006083 putative radical transfer pathway; other site 351745006084 diiron center [ion binding]; other site 351745006085 tyrosyl radical; other site 351745006086 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 351745006087 ATP cone domain; Region: ATP-cone; pfam03477 351745006088 Class I ribonucleotide reductase; Region: RNR_I; cd01679 351745006089 active site 351745006090 dimer interface [polypeptide binding]; other site 351745006091 catalytic residues [active] 351745006092 effector binding site; other site 351745006093 R2 peptide binding site; other site 351745006094 phosphoglycolate phosphatase; Provisional; Region: PRK13222 351745006095 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351745006096 active site 351745006097 motif I; other site 351745006098 motif II; other site 351745006099 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 351745006100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745006101 S-adenosylmethionine binding site [chemical binding]; other site 351745006102 DNA gyrase subunit A; Validated; Region: PRK05560 351745006103 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 351745006104 CAP-like domain; other site 351745006105 active site 351745006106 primary dimer interface [polypeptide binding]; other site 351745006107 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 351745006108 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 351745006109 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 351745006110 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 351745006111 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 351745006112 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 351745006113 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 351745006114 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 351745006115 catalytic residue [active] 351745006116 ribulokinase; Provisional; Region: PRK04123 351745006117 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 351745006118 N- and C-terminal domain interface [polypeptide binding]; other site 351745006119 active site 351745006120 MgATP binding site [chemical binding]; other site 351745006121 catalytic site [active] 351745006122 metal binding site [ion binding]; metal-binding site 351745006123 carbohydrate binding site [chemical binding]; other site 351745006124 homodimer interface [polypeptide binding]; other site 351745006125 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 351745006126 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 351745006127 intersubunit interface [polypeptide binding]; other site 351745006128 active site 351745006129 Zn2+ binding site [ion binding]; other site 351745006130 L-arabinose isomerase; Provisional; Region: PRK02929 351745006131 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 351745006132 hexamer (dimer of trimers) interface [polypeptide binding]; other site 351745006133 trimer interface [polypeptide binding]; other site 351745006134 substrate binding site [chemical binding]; other site 351745006135 Mn binding site [ion binding]; other site 351745006136 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 351745006137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351745006138 active site 351745006139 motif I; other site 351745006140 motif II; other site 351745006141 Transcriptional regulators [Transcription]; Region: FadR; COG2186 351745006142 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 351745006143 DNA-binding site [nucleotide binding]; DNA binding site 351745006144 FCD domain; Region: FCD; pfam07729 351745006145 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 351745006146 substrate binding site [chemical binding]; other site 351745006147 active site 351745006148 dihydroxy-acid dehydratase; Validated; Region: PRK06131 351745006149 short chain dehydrogenase; Provisional; Region: PRK12939 351745006150 classical (c) SDRs; Region: SDR_c; cd05233 351745006151 NAD(P) binding site [chemical binding]; other site 351745006152 active site 351745006153 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 351745006154 active site 351745006155 catalytic residues [active] 351745006156 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 351745006157 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 351745006158 putative ligand binding site [chemical binding]; other site 351745006159 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 351745006160 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 351745006161 Walker A/P-loop; other site 351745006162 ATP binding site [chemical binding]; other site 351745006163 Q-loop/lid; other site 351745006164 ABC transporter signature motif; other site 351745006165 Walker B; other site 351745006166 D-loop; other site 351745006167 H-loop/switch region; other site 351745006168 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 351745006169 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 351745006170 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 351745006171 TM-ABC transporter signature motif; other site 351745006172 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 351745006173 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 351745006174 TM-ABC transporter signature motif; other site 351745006175 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 351745006176 active site 351745006177 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 351745006178 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745006179 dimerization interface [polypeptide binding]; other site 351745006180 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745006181 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745006182 dimer interface [polypeptide binding]; other site 351745006183 putative CheW interface [polypeptide binding]; other site 351745006184 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 351745006185 active site 351745006186 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 351745006187 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 351745006188 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 351745006189 substrate binding site [chemical binding]; other site 351745006190 active site 351745006191 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 351745006192 active site 351745006193 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 351745006194 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 351745006195 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 351745006196 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 351745006197 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 351745006198 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 351745006199 substrate binding site [chemical binding]; other site 351745006200 active site 351745006201 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 351745006202 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 351745006203 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 351745006204 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 351745006205 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 351745006206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745006207 homodimer interface [polypeptide binding]; other site 351745006208 catalytic residue [active] 351745006209 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 351745006210 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 351745006211 hinge; other site 351745006212 active site 351745006213 cytidylate kinase; Provisional; Region: cmk; PRK00023 351745006214 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 351745006215 CMP-binding site; other site 351745006216 The sites determining sugar specificity; other site 351745006217 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 351745006218 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 351745006219 RNA binding site [nucleotide binding]; other site 351745006220 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 351745006221 RNA binding site [nucleotide binding]; other site 351745006222 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 351745006223 RNA binding site [nucleotide binding]; other site 351745006224 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 351745006225 RNA binding site [nucleotide binding]; other site 351745006226 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 351745006227 RNA binding site [nucleotide binding]; other site 351745006228 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 351745006229 RNA binding site [nucleotide binding]; other site 351745006230 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 351745006231 IHF dimer interface [polypeptide binding]; other site 351745006232 IHF - DNA interface [nucleotide binding]; other site 351745006233 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 351745006234 tetratricopeptide repeat protein; Provisional; Region: PRK11788 351745006235 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 351745006236 active site 351745006237 dimer interface [polypeptide binding]; other site 351745006238 short chain dehydrogenase; Provisional; Region: PRK07576 351745006239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 351745006240 NAD(P) binding site [chemical binding]; other site 351745006241 active site 351745006242 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 351745006243 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 351745006244 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 351745006245 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 351745006246 active site 351745006247 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 351745006248 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 351745006249 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 351745006250 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 351745006251 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 351745006252 domain interface [polypeptide binding]; other site 351745006253 putative active site [active] 351745006254 catalytic site [active] 351745006255 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 351745006256 domain interface [polypeptide binding]; other site 351745006257 putative active site [active] 351745006258 catalytic site [active] 351745006259 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 351745006260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745006261 putative substrate translocation pore; other site 351745006262 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 351745006263 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 351745006264 Uncharacterized conserved protein [Function unknown]; Region: COG3148 351745006265 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 351745006266 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 351745006267 DEAD-like helicases superfamily; Region: DEXDc; smart00487 351745006268 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351745006269 ATP binding site [chemical binding]; other site 351745006270 putative Mg++ binding site [ion binding]; other site 351745006271 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745006272 nucleotide binding region [chemical binding]; other site 351745006273 ATP-binding site [chemical binding]; other site 351745006274 ecotin; Provisional; Region: PRK03719 351745006275 secondary substrate binding site; other site 351745006276 primary substrate binding site; other site 351745006277 inhibition loop; other site 351745006278 dimerization interface [polypeptide binding]; other site 351745006279 multidrug efflux protein; Reviewed; Region: PRK01766 351745006280 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 351745006281 cation binding site [ion binding]; other site 351745006282 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 351745006283 Lumazine binding domain; Region: Lum_binding; pfam00677 351745006284 Lumazine binding domain; Region: Lum_binding; pfam00677 351745006285 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 351745006286 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 351745006287 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 351745006288 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 351745006289 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 351745006290 active site 351745006291 dimer interface [polypeptide binding]; other site 351745006292 motif 1; other site 351745006293 motif 2; other site 351745006294 motif 3; other site 351745006295 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 351745006296 anticodon binding site; other site 351745006297 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 351745006298 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 351745006299 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 351745006300 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 351745006301 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 351745006302 23S rRNA binding site [nucleotide binding]; other site 351745006303 L21 binding site [polypeptide binding]; other site 351745006304 L13 binding site [polypeptide binding]; other site 351745006305 thioredoxin reductase; Provisional; Region: PRK10262 351745006306 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 351745006307 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 351745006308 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 351745006309 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 351745006310 hexamer interface [polypeptide binding]; other site 351745006311 ligand binding site [chemical binding]; other site 351745006312 putative active site [active] 351745006313 NAD(P) binding site [chemical binding]; other site 351745006314 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 351745006315 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 351745006316 putative DNA binding site [nucleotide binding]; other site 351745006317 putative Zn2+ binding site [ion binding]; other site 351745006318 AsnC family; Region: AsnC_trans_reg; pfam01037 351745006319 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 351745006320 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 351745006321 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 351745006322 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 351745006323 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 351745006324 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 351745006325 recombination factor protein RarA; Reviewed; Region: PRK13342 351745006326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745006327 Walker A motif; other site 351745006328 ATP binding site [chemical binding]; other site 351745006329 Walker B motif; other site 351745006330 arginine finger; other site 351745006331 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 351745006332 camphor resistance protein CrcB; Provisional; Region: PRK14197 351745006333 seryl-tRNA synthetase; Provisional; Region: PRK05431 351745006334 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 351745006335 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 351745006336 dimer interface [polypeptide binding]; other site 351745006337 active site 351745006338 motif 1; other site 351745006339 motif 2; other site 351745006340 motif 3; other site 351745006341 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 351745006342 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 351745006343 sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011 351745006344 sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010 351745006345 sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012 351745006346 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 351745006347 YccA-like proteins; Region: YccA_like; cd10433 351745006348 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 351745006349 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745006350 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 351745006351 dimerization interface [polypeptide binding]; other site 351745006352 putative transporter; Provisional; Region: PRK11043 351745006353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745006354 putative substrate translocation pore; other site 351745006355 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 351745006356 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 351745006357 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 351745006358 DNA binding site [nucleotide binding] 351745006359 dimer interface [polypeptide binding]; other site 351745006360 active site 351745006361 Int/Topo IB signature motif; other site 351745006362 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 351745006363 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 351745006364 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 351745006365 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 351745006366 CoenzymeA binding site [chemical binding]; other site 351745006367 subunit interaction site [polypeptide binding]; other site 351745006368 PHB binding site; other site 351745006369 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 351745006370 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 351745006371 CoenzymeA binding site [chemical binding]; other site 351745006372 subunit interaction site [polypeptide binding]; other site 351745006373 PHB binding site; other site 351745006374 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 351745006375 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 351745006376 active site 351745006377 catalytic tetrad [active] 351745006378 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 351745006379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 351745006380 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 351745006381 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 351745006382 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 351745006383 putative C-terminal domain interface [polypeptide binding]; other site 351745006384 putative GSH binding site (G-site) [chemical binding]; other site 351745006385 putative dimer interface [polypeptide binding]; other site 351745006386 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 351745006387 N-terminal domain interface [polypeptide binding]; other site 351745006388 dimer interface [polypeptide binding]; other site 351745006389 substrate binding pocket (H-site) [chemical binding]; other site 351745006390 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 351745006391 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 351745006392 HTH-like domain; Region: HTH_21; pfam13276 351745006393 Integrase core domain; Region: rve; pfam00665 351745006394 Integrase core domain; Region: rve_3; pfam13683 351745006395 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 351745006396 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 351745006397 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 351745006398 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 351745006399 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745006400 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745006401 dimer interface [polypeptide binding]; other site 351745006402 putative CheW interface [polypeptide binding]; other site 351745006403 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 351745006404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 351745006405 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 351745006406 homotrimer interaction site [polypeptide binding]; other site 351745006407 putative active site [active] 351745006408 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 351745006409 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 351745006410 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 351745006411 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 351745006412 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 351745006413 Low-spin heme binding site [chemical binding]; other site 351745006414 Putative water exit pathway; other site 351745006415 Binuclear center (active site) [active] 351745006416 Putative proton exit pathway; other site 351745006417 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 351745006418 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 351745006419 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 351745006420 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 351745006421 Cytochrome c; Region: Cytochrom_C; pfam00034 351745006422 Cytochrome c; Region: Cytochrom_C; pfam00034 351745006423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 351745006424 FixH; Region: FixH; pfam05751 351745006425 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 351745006426 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 351745006427 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 351745006428 metal-binding site [ion binding] 351745006429 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 351745006430 Soluble P-type ATPase [General function prediction only]; Region: COG4087 351745006431 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 351745006432 Family description; Region: DsbD_2; pfam13386 351745006433 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 351745006434 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 351745006435 ligand binding site [chemical binding]; other site 351745006436 flexible hinge region; other site 351745006437 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 351745006438 putative switch regulator; other site 351745006439 non-specific DNA interactions [nucleotide binding]; other site 351745006440 DNA binding site [nucleotide binding] 351745006441 sequence specific DNA binding site [nucleotide binding]; other site 351745006442 putative cAMP binding site [chemical binding]; other site 351745006443 universal stress protein UspE; Provisional; Region: PRK11175 351745006444 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 351745006445 Ligand Binding Site [chemical binding]; other site 351745006446 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 351745006447 Ligand Binding Site [chemical binding]; other site 351745006448 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 351745006449 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 351745006450 Ligand Binding Site [chemical binding]; other site 351745006451 Protein of unknown function (DUF2987); Region: DUF2987; pfam11205 351745006452 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 351745006453 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 351745006454 phosphate binding site [ion binding]; other site 351745006455 putative substrate binding pocket [chemical binding]; other site 351745006456 dimer interface [polypeptide binding]; other site 351745006457 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 351745006458 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 351745006459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745006460 homodimer interface [polypeptide binding]; other site 351745006461 catalytic residue [active] 351745006462 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 351745006463 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 351745006464 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 351745006465 putative active site [active] 351745006466 Zn binding site [ion binding]; other site 351745006467 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 351745006468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745006469 active site 351745006470 phosphorylation site [posttranslational modification] 351745006471 intermolecular recognition site; other site 351745006472 dimerization interface [polypeptide binding]; other site 351745006473 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745006474 DNA binding site [nucleotide binding] 351745006475 Homeodomain-like domain; Region: HTH_32; pfam13565 351745006476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 351745006477 Integrase core domain; Region: rve; pfam00665 351745006478 Integrase core domain; Region: rve_3; pfam13683 351745006479 Transposase; Region: HTH_Tnp_1; cl17663 351745006480 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 351745006481 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745006482 N-terminal plug; other site 351745006483 ligand-binding site [chemical binding]; other site 351745006484 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 351745006485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745006486 Walker A motif; other site 351745006487 ATP binding site [chemical binding]; other site 351745006488 Walker B motif; other site 351745006489 arginine finger; other site 351745006490 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 351745006491 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 351745006492 RuvA N terminal domain; Region: RuvA_N; pfam01330 351745006493 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 351745006494 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 351745006495 active site 351745006496 putative DNA-binding cleft [nucleotide binding]; other site 351745006497 dimer interface [polypeptide binding]; other site 351745006498 hypothetical protein; Validated; Region: PRK00110 351745006499 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 351745006500 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 351745006501 dimer interface [polypeptide binding]; other site 351745006502 anticodon binding site; other site 351745006503 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 351745006504 homodimer interface [polypeptide binding]; other site 351745006505 motif 1; other site 351745006506 active site 351745006507 motif 2; other site 351745006508 GAD domain; Region: GAD; pfam02938 351745006509 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 351745006510 active site 351745006511 motif 3; other site 351745006512 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 351745006513 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 351745006514 substrate binding pocket [chemical binding]; other site 351745006515 membrane-bound complex binding site; other site 351745006516 hinge residues; other site 351745006517 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 351745006518 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 351745006519 substrate binding pocket [chemical binding]; other site 351745006520 membrane-bound complex binding site; other site 351745006521 hinge residues; other site 351745006522 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 351745006523 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 351745006524 substrate binding pocket [chemical binding]; other site 351745006525 membrane-bound complex binding site; other site 351745006526 hinge residues; other site 351745006527 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745006528 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745006529 metal binding site [ion binding]; metal-binding site 351745006530 active site 351745006531 I-site; other site 351745006532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745006533 S-adenosylmethionine binding site [chemical binding]; other site 351745006534 Methyltransferase domain; Region: Methyltransf_23; pfam13489 351745006535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745006536 S-adenosylmethionine binding site [chemical binding]; other site 351745006537 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 351745006538 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745006539 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745006540 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 351745006541 dimerization interface [polypeptide binding]; other site 351745006542 SprA-related family; Region: SprA-related; pfam12118 351745006543 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 351745006544 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351745006545 FeS/SAM binding site; other site 351745006546 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 351745006547 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 351745006548 ThiS interaction site; other site 351745006549 putative active site [active] 351745006550 tetramer interface [polypeptide binding]; other site 351745006551 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 351745006552 thiS-thiF/thiG interaction site; other site 351745006553 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 351745006554 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 351745006555 ATP binding site [chemical binding]; other site 351745006556 substrate interface [chemical binding]; other site 351745006557 Phosphomethylpyrimidine kinase; Region: Phos_pyr_kin; pfam08543 351745006558 ATP binding site [chemical binding]; other site 351745006559 substrate binding site [chemical binding]; other site 351745006560 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 351745006561 thiamine phosphate binding site [chemical binding]; other site 351745006562 active site 351745006563 pyrophosphate binding site [ion binding]; other site 351745006564 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 351745006565 ThiC-associated domain; Region: ThiC-associated; pfam13667 351745006566 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 351745006567 Haemolysin-III related; Region: HlyIII; cl03831 351745006568 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 351745006569 DTW domain; Region: DTW; cl01221 351745006570 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_27; cd04686 351745006571 nudix motif; other site 351745006572 PAS fold; Region: PAS_4; pfam08448 351745006573 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745006574 putative active site [active] 351745006575 heme pocket [chemical binding]; other site 351745006576 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745006577 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 351745006578 putative active site [active] 351745006579 heme pocket [chemical binding]; other site 351745006580 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745006581 putative active site [active] 351745006582 heme pocket [chemical binding]; other site 351745006583 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745006584 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745006585 metal binding site [ion binding]; metal-binding site 351745006586 active site 351745006587 I-site; other site 351745006588 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745006589 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 351745006590 Family of unknown function (DUF633); Region: DUF633; pfam04816 351745006591 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 351745006592 Ligand Binding Site [chemical binding]; other site 351745006593 Helix-turn-helix domain; Region: HTH_18; pfam12833 351745006594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 351745006595 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 351745006596 Uncharacterized conserved protein [Function unknown]; Region: COG2128 351745006597 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 351745006598 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 351745006599 putative RNA binding site [nucleotide binding]; other site 351745006600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 351745006601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 351745006602 Helix-turn-helix domain; Region: HTH_18; pfam12833 351745006603 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 351745006604 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 351745006605 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 351745006606 transmembrane helices; other site 351745006607 Uncharacterized conserved protein [Function unknown]; Region: COG2850 351745006608 Cupin-like domain; Region: Cupin_8; pfam13621 351745006609 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 351745006610 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 351745006611 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 351745006612 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 351745006613 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 351745006614 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 351745006615 [4Fe-4S] binding site [ion binding]; other site 351745006616 molybdopterin cofactor binding site; other site 351745006617 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 351745006618 molybdopterin cofactor binding site; other site 351745006619 NapD protein; Region: NapD; pfam03927 351745006620 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 351745006621 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 351745006622 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351745006623 ATP binding site [chemical binding]; other site 351745006624 putative Mg++ binding site [ion binding]; other site 351745006625 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745006626 nucleotide binding region [chemical binding]; other site 351745006627 ATP-binding site [chemical binding]; other site 351745006628 Helicase associated domain (HA2); Region: HA2; pfam04408 351745006629 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 351745006630 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 351745006631 FOG: CBS domain [General function prediction only]; Region: COG0517 351745006632 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 351745006633 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 351745006634 catalytic nucleophile [active] 351745006635 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 351745006636 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 351745006637 Surface antigen; Region: Bac_surface_Ag; pfam01103 351745006638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 351745006639 Family of unknown function (DUF490); Region: DUF490; pfam04357 351745006640 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 351745006641 5S rRNA interface [nucleotide binding]; other site 351745006642 CTC domain interface [polypeptide binding]; other site 351745006643 L16 interface [polypeptide binding]; other site 351745006644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 351745006645 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 351745006646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 351745006647 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 351745006648 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 351745006649 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 351745006650 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 351745006651 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 351745006652 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 351745006653 Protein of unknown function (DUF2989); Region: DUF2989; pfam11207 351745006654 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 351745006655 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 351745006656 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 351745006657 quinolinate synthetase; Provisional; Region: PRK09375 351745006658 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 351745006659 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 351745006660 E3 interaction surface; other site 351745006661 lipoyl attachment site [posttranslational modification]; other site 351745006662 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 351745006663 E3 interaction surface; other site 351745006664 lipoyl attachment site [posttranslational modification]; other site 351745006665 e3 binding domain; Region: E3_binding; pfam02817 351745006666 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 351745006667 3-methyl-2-oxobutanate dehydrogenase; Provisional; Region: PTZ00182 351745006668 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 351745006669 alpha subunit interface [polypeptide binding]; other site 351745006670 TPP binding site [chemical binding]; other site 351745006671 heterodimer interface [polypeptide binding]; other site 351745006672 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 351745006673 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 351745006674 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 351745006675 tetramer interface [polypeptide binding]; other site 351745006676 TPP-binding site [chemical binding]; other site 351745006677 heterodimer interface [polypeptide binding]; other site 351745006678 phosphorylation loop region [posttranslational modification] 351745006679 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 351745006680 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 351745006681 putative active site [active] 351745006682 Zn binding site [ion binding]; other site 351745006683 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 351745006684 phosphoglucomutase; Validated; Region: PRK07564 351745006685 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 351745006686 active site 351745006687 substrate binding site [chemical binding]; other site 351745006688 metal binding site [ion binding]; metal-binding site 351745006689 SeqA protein; Region: SeqA; pfam03925 351745006690 acyl-CoA esterase; Provisional; Region: PRK10673 351745006691 PGAP1-like protein; Region: PGAP1; pfam07819 351745006692 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 351745006693 LexA regulated protein; Provisional; Region: PRK11675 351745006694 flavodoxin FldA; Validated; Region: PRK09267 351745006695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 351745006696 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 351745006697 elongation factor P; Validated; Region: PRK00529 351745006698 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 351745006699 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 351745006700 RNA binding site [nucleotide binding]; other site 351745006701 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 351745006702 RNA binding site [nucleotide binding]; other site 351745006703 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 351745006704 aminotransferase AlaT; Validated; Region: PRK09265 351745006705 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 351745006706 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745006707 homodimer interface [polypeptide binding]; other site 351745006708 catalytic residue [active] 351745006709 5'-nucleotidase; Provisional; Region: PRK03826 351745006710 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 351745006711 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 351745006712 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 351745006713 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 351745006714 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 351745006715 active site 351745006716 intersubunit interface [polypeptide binding]; other site 351745006717 catalytic residue [active] 351745006718 phosphogluconate dehydratase; Validated; Region: PRK09054 351745006719 6-phosphogluconate dehydratase; Region: edd; TIGR01196 351745006720 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 351745006721 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 351745006722 putative active site [active] 351745006723 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 351745006724 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 351745006725 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 351745006726 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 351745006727 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 351745006728 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 351745006729 putative active site [active] 351745006730 pyruvate kinase; Provisional; Region: PRK05826 351745006731 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 351745006732 domain interfaces; other site 351745006733 active site 351745006734 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 351745006735 acyl-CoA dehydrogenase; Reviewed; Region: PRK13026 351745006736 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 351745006737 active site 351745006738 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 351745006739 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 351745006740 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 351745006741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 351745006742 Smr domain; Region: Smr; pfam01713 351745006743 SnoaL-like domain; Region: SnoaL_3; pfam13474 351745006744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 351745006745 SEC-C motif; Region: SEC-C; pfam02810 351745006746 SEC-C motif; Region: SEC-C; pfam02810 351745006747 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 351745006748 GAF domain; Region: GAF; pfam01590 351745006749 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745006750 PAS fold; Region: PAS_3; pfam08447 351745006751 putative active site [active] 351745006752 heme pocket [chemical binding]; other site 351745006753 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745006754 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745006755 metal binding site [ion binding]; metal-binding site 351745006756 active site 351745006757 I-site; other site 351745006758 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745006759 Protein of unknown function (DUF406); Region: DUF406; pfam04175 351745006760 Ribosomal S4P (gammaproteobacterial); Region: Ribosomal_S4Pg; pfam11993 351745006761 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 351745006762 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 351745006763 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 351745006764 Ligand Binding Site [chemical binding]; other site 351745006765 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 351745006766 excinuclease ABC subunit B; Provisional; Region: PRK05298 351745006767 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351745006768 ATP binding site [chemical binding]; other site 351745006769 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745006770 nucleotide binding region [chemical binding]; other site 351745006771 ATP-binding site [chemical binding]; other site 351745006772 Ultra-violet resistance protein B; Region: UvrB; pfam12344 351745006773 UvrB/uvrC motif; Region: UVR; pfam02151 351745006774 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745006775 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745006776 active site 351745006777 I-site; other site 351745006778 metal binding site [ion binding]; metal-binding site 351745006779 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745006780 electron transport complex protein RsxA; Provisional; Region: PRK05151 351745006781 ferredoxin; Provisional; Region: PRK08764 351745006782 Putative Fe-S cluster; Region: FeS; pfam04060 351745006783 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 351745006784 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 351745006785 SLBB domain; Region: SLBB; pfam10531 351745006786 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 351745006787 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 351745006788 electron transport complex protein RnfG; Validated; Region: PRK01908 351745006789 electron transport complex RsxE subunit; Provisional; Region: PRK12405 351745006790 endonuclease III; Provisional; Region: PRK10702 351745006791 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 351745006792 minor groove reading motif; other site 351745006793 helix-hairpin-helix signature motif; other site 351745006794 substrate binding pocket [chemical binding]; other site 351745006795 active site 351745006796 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 351745006797 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 351745006798 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 351745006799 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 351745006800 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 351745006801 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 351745006802 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745006803 N-terminal plug; other site 351745006804 ligand-binding site [chemical binding]; other site 351745006805 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 351745006806 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 351745006807 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 351745006808 ABC transporter; Region: ABC_tran_2; pfam12848 351745006809 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 351745006810 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 351745006811 CoA binding domain; Region: CoA_binding_2; pfam13380 351745006812 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 351745006813 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 351745006814 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 351745006815 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 351745006816 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 351745006817 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 351745006818 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 351745006819 dimerization interface [polypeptide binding]; other site 351745006820 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 351745006821 ATP binding site [chemical binding]; other site 351745006822 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 351745006823 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 351745006824 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 351745006825 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 351745006826 putative acyl-acceptor binding pocket; other site 351745006827 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 351745006828 IHF dimer interface [polypeptide binding]; other site 351745006829 IHF - DNA interface [nucleotide binding]; other site 351745006830 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 351745006831 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 351745006832 putative tRNA-binding site [nucleotide binding]; other site 351745006833 B3/4 domain; Region: B3_4; pfam03483 351745006834 tRNA synthetase B5 domain; Region: B5; smart00874 351745006835 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 351745006836 dimer interface [polypeptide binding]; other site 351745006837 motif 1; other site 351745006838 motif 3; other site 351745006839 motif 2; other site 351745006840 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 351745006841 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 351745006842 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 351745006843 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 351745006844 dimer interface [polypeptide binding]; other site 351745006845 motif 1; other site 351745006846 active site 351745006847 motif 2; other site 351745006848 motif 3; other site 351745006849 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745006850 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745006851 dimer interface [polypeptide binding]; other site 351745006852 putative CheW interface [polypeptide binding]; other site 351745006853 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 351745006854 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745006855 N-terminal plug; other site 351745006856 ligand-binding site [chemical binding]; other site 351745006857 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 351745006858 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 351745006859 DEAD/DEAH box helicase; Region: DEAD; pfam00270 351745006860 DEAD_2; Region: DEAD_2; pfam06733 351745006861 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 351745006862 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 351745006863 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 351745006864 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 351745006865 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 351745006866 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 351745006867 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 351745006868 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 351745006869 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 351745006870 Beta-lactamase; Region: Beta-lactamase; pfam00144 351745006871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745006872 Major Facilitator Superfamily; Region: MFS_1; pfam07690 351745006873 putative substrate translocation pore; other site 351745006874 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 351745006875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745006876 putative substrate translocation pore; other site 351745006877 Beta protein; Region: Beta_protein; pfam14350 351745006878 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 351745006879 Domain of unknown function (DUF955); Region: DUF955; pfam06114 351745006880 multiple promoter invertase; Provisional; Region: mpi; PRK13413 351745006881 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 351745006882 catalytic residues [active] 351745006883 catalytic nucleophile [active] 351745006884 Presynaptic Site I dimer interface [polypeptide binding]; other site 351745006885 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 351745006886 Synaptic Flat tetramer interface [polypeptide binding]; other site 351745006887 Synaptic Site I dimer interface [polypeptide binding]; other site 351745006888 DNA binding site [nucleotide binding] 351745006889 Protein of unknown function (DUF2787); Region: DUF2787; pfam10980 351745006890 hypothetical protein; Reviewed; Region: PRK00024 351745006891 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 351745006892 MPN+ (JAMM) motif; other site 351745006893 Zinc-binding site [ion binding]; other site 351745006894 putative DNA binding site [nucleotide binding]; other site 351745006895 Helix-turn-helix domain; Region: HTH_20; pfam12840 351745006896 putative Zn2+ binding site [ion binding]; other site 351745006897 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; pfam08273 351745006898 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 351745006899 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 351745006900 active site 351745006901 metal binding site [ion binding]; metal-binding site 351745006902 interdomain interaction site; other site 351745006903 hypothetical protein; Provisional; Region: PRK14709 351745006904 D5 N terminal like; Region: D5_N; smart00885 351745006905 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 351745006906 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 351745006907 active site 351745006908 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 351745006909 Catalytic domain of Protein Kinases; Region: PKc; cd00180 351745006910 active site 351745006911 ATP binding site [chemical binding]; other site 351745006912 substrate binding site [chemical binding]; other site 351745006913 activation loop (A-loop); other site 351745006914 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 351745006915 Catalytic domain of Protein Kinases; Region: PKc; cd00180 351745006916 active site 351745006917 ATP binding site [chemical binding]; other site 351745006918 substrate binding site [chemical binding]; other site 351745006919 activation loop (A-loop); other site 351745006920 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 351745006921 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 351745006922 active site 351745006923 DNA binding site [nucleotide binding] 351745006924 Int/Topo IB signature motif; other site 351745006925 Nitrate and nitrite sensing; Region: NIT; pfam08376 351745006926 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 351745006927 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745006928 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745006929 dimer interface [polypeptide binding]; other site 351745006930 putative CheW interface [polypeptide binding]; other site 351745006931 hypothetical protein; Provisional; Region: PRK11111 351745006932 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 351745006933 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 351745006934 putative catalytic cysteine [active] 351745006935 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 351745006936 putative active site [active] 351745006937 metal binding site [ion binding]; metal-binding site 351745006938 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 351745006939 putative active site [active] 351745006940 Zn binding site [ion binding]; other site 351745006941 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 351745006942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745006943 Coenzyme A binding pocket [chemical binding]; other site 351745006944 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 351745006945 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 351745006946 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 351745006947 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 351745006948 Fumarase C-terminus; Region: Fumerase_C; pfam05683 351745006949 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 351745006950 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 351745006951 chorismate binding enzyme; Region: Chorismate_bind; cl10555 351745006952 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 351745006953 putative active site [active] 351745006954 putative CoA binding site [chemical binding]; other site 351745006955 nudix motif; other site 351745006956 metal binding site [ion binding]; metal-binding site 351745006957 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 351745006958 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 351745006959 putative dimer interface [polypeptide binding]; other site 351745006960 putative anticodon binding site; other site 351745006961 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 351745006962 homodimer interface [polypeptide binding]; other site 351745006963 motif 1; other site 351745006964 motif 2; other site 351745006965 active site 351745006966 motif 3; other site 351745006967 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 351745006968 substrate binding pocket [chemical binding]; other site 351745006969 membrane-bound complex binding site; other site 351745006970 hinge residues; other site 351745006971 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 351745006972 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 351745006973 ATP-grasp domain; Region: ATP-grasp_4; cl17255 351745006974 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 351745006975 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 351745006976 PAS domain; Region: PAS_9; pfam13426 351745006977 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745006978 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745006979 metal binding site [ion binding]; metal-binding site 351745006980 active site 351745006981 I-site; other site 351745006982 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745006983 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 351745006984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745006985 S-adenosylmethionine binding site [chemical binding]; other site 351745006986 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 351745006987 rhombotail lipoprotein; Region: rhombo_lipo; TIGR04179 351745006988 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 351745006989 active site 351745006990 catalytic residues [active] 351745006991 metal binding site [ion binding]; metal-binding site 351745006992 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 351745006993 active site 351745006994 DNA binding site [nucleotide binding] 351745006995 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 351745006996 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 351745006997 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 351745006998 putative active site [active] 351745006999 putative dimer interface [polypeptide binding]; other site 351745007000 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 351745007001 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 351745007002 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 351745007003 active site 351745007004 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 351745007005 PRC-barrel domain; Region: PRC; pfam05239 351745007006 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 351745007007 BON domain; Region: BON; pfam04972 351745007008 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 351745007009 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 351745007010 ligand binding site [chemical binding]; other site 351745007011 flexible hinge region; other site 351745007012 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 351745007013 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 351745007014 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 351745007015 ligand binding site [chemical binding]; other site 351745007016 flexible hinge region; other site 351745007017 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 351745007018 outer membrane lipoprotein; Provisional; Region: PRK11023 351745007019 BON domain; Region: BON; pfam04972 351745007020 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 351745007021 BON domain; Region: BON; pfam04972 351745007022 BON domain; Region: BON; pfam04972 351745007023 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 351745007024 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 351745007025 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 351745007026 ligand binding site [chemical binding]; other site 351745007027 TIGR03503 family protein; Region: TIGR03503 351745007028 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 351745007029 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 351745007030 active site 351745007031 catalytic site [active] 351745007032 substrate binding site [chemical binding]; other site 351745007033 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 351745007034 RNA/DNA hybrid binding site [nucleotide binding]; other site 351745007035 active site 351745007036 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 351745007037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745007038 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 351745007039 putative dimerization interface [polypeptide binding]; other site 351745007040 Methyltransferase domain; Region: Methyltransf_11; pfam08241 351745007041 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 351745007042 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 351745007043 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 351745007044 N-acetyl-D-glucosamine binding site [chemical binding]; other site 351745007045 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 351745007046 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 351745007047 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 351745007048 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 351745007049 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 351745007050 ribonuclease activity regulator protein RraA; Reviewed; Region: PRK12487 351745007051 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 351745007052 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 351745007053 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 351745007054 ATP binding site [chemical binding]; other site 351745007055 Mg++ binding site [ion binding]; other site 351745007056 motif III; other site 351745007057 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745007058 nucleotide binding region [chemical binding]; other site 351745007059 ATP-binding site [chemical binding]; other site 351745007060 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 351745007061 substrate binding site [chemical binding]; other site 351745007062 hypothetical protein; Provisional; Region: PRK05170 351745007063 YcgL domain; Region: YcgL; pfam05166 351745007064 septum formation inhibitor; Reviewed; Region: minC; PRK04804 351745007065 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 351745007066 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 351745007067 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 351745007068 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 351745007069 Switch I; other site 351745007070 Switch II; other site 351745007071 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 351745007072 ribonuclease D; Region: rnd; TIGR01388 351745007073 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 351745007074 catalytic site [active] 351745007075 putative active site [active] 351745007076 putative substrate binding site [chemical binding]; other site 351745007077 HRDC domain; Region: HRDC; pfam00570 351745007078 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 351745007079 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 351745007080 acyl-activating enzyme (AAE) consensus motif; other site 351745007081 putative AMP binding site [chemical binding]; other site 351745007082 putative active site [active] 351745007083 putative CoA binding site [chemical binding]; other site 351745007084 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 351745007085 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 351745007086 PGAP1-like protein; Region: PGAP1; pfam07819 351745007087 Predicted methyltransferase [General function prediction only]; Region: COG4798 351745007088 Methyltransferase domain; Region: Methyltransf_23; pfam13489 351745007089 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 351745007090 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 351745007091 Glycoprotease family; Region: Peptidase_M22; pfam00814 351745007092 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 351745007093 dimer interface [polypeptide binding]; other site 351745007094 active site 351745007095 Schiff base residues; other site 351745007096 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 351745007097 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 351745007098 methionine sulfoxide reductase A; Provisional; Region: PRK14054 351745007099 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 351745007100 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 351745007101 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 351745007102 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 351745007103 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 351745007104 GTP/Mg2+ binding site [chemical binding]; other site 351745007105 G4 box; other site 351745007106 G5 box; other site 351745007107 G1 box; other site 351745007108 Switch I region; other site 351745007109 G2 box; other site 351745007110 G3 box; other site 351745007111 Switch II region; other site 351745007112 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 351745007113 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745007114 Coenzyme A binding pocket [chemical binding]; other site 351745007115 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 351745007116 Low molecular weight phosphatase family; Region: LMWPc; cd00115 351745007117 active site 351745007118 DNA ligase; Provisional; Region: PRK09125 351745007119 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 351745007120 DNA binding site [nucleotide binding] 351745007121 active site 351745007122 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 351745007123 DNA binding site [nucleotide binding] 351745007124 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 351745007125 transcriptional regulator HdfR; Provisional; Region: PRK03601 351745007126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745007127 LysR substrate binding domain; Region: LysR_substrate; pfam03466 351745007128 dimerization interface [polypeptide binding]; other site 351745007129 hypothetical protein; Provisional; Region: PRK11027 351745007130 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 351745007131 ATP-grasp domain; Region: ATP-grasp_4; cl17255 351745007132 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 351745007133 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 351745007134 PA/protease or protease-like domain interface [polypeptide binding]; other site 351745007135 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 351745007136 Peptidase family M28; Region: Peptidase_M28; pfam04389 351745007137 metal binding site [ion binding]; metal-binding site 351745007138 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745007139 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745007140 metal binding site [ion binding]; metal-binding site 351745007141 active site 351745007142 I-site; other site 351745007143 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 351745007144 active site 351745007145 catalytic site [active] 351745007146 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 351745007147 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 351745007148 vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461 351745007149 metal ion-dependent adhesion site (MIDAS); other site 351745007150 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 351745007151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745007152 active site 351745007153 phosphorylation site [posttranslational modification] 351745007154 intermolecular recognition site; other site 351745007155 dimerization interface [polypeptide binding]; other site 351745007156 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745007157 DNA binding site [nucleotide binding] 351745007158 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 351745007159 DOMON-like type 9 carbohydrate binding module at the N-terminus of bacterial sensor histidine kinases; Region: CBM9_like_HisKa; cd09622 351745007160 putative ligand binding site [chemical binding]; other site 351745007161 HAMP domain; Region: HAMP; pfam00672 351745007162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745007163 dimer interface [polypeptide binding]; other site 351745007164 phosphorylation site [posttranslational modification] 351745007165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745007166 ATP binding site [chemical binding]; other site 351745007167 Mg2+ binding site [ion binding]; other site 351745007168 G-X-G motif; other site 351745007169 cystathionine beta-lyase; Provisional; Region: PRK09028 351745007170 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 351745007171 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 351745007172 catalytic residue [active] 351745007173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 351745007174 CreA protein; Region: CreA; pfam05981 351745007175 putative chaperone; Provisional; Region: PRK11678 351745007176 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 351745007177 nucleotide binding site [chemical binding]; other site 351745007178 putative NEF/HSP70 interaction site [polypeptide binding]; other site 351745007179 SBD interface [polypeptide binding]; other site 351745007180 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 351745007181 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 351745007182 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 351745007183 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 351745007184 domain interface [polypeptide binding]; other site 351745007185 active site 351745007186 catalytic site [active] 351745007187 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 351745007188 domain interface [polypeptide binding]; other site 351745007189 active site 351745007190 catalytic site [active] 351745007191 exopolyphosphatase; Region: exo_poly_only; TIGR03706 351745007192 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 351745007193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745007194 Major Facilitator Superfamily; Region: MFS_1; pfam07690 351745007195 putative substrate translocation pore; other site 351745007196 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745007197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745007198 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 351745007199 dimerization interface [polypeptide binding]; other site 351745007200 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 351745007201 acyl-CoA thioesterase II; Provisional; Region: PRK10526 351745007202 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 351745007203 active site 351745007204 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 351745007205 catalytic triad [active] 351745007206 dimer interface [polypeptide binding]; other site 351745007207 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 351745007208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 351745007209 NAD(P) binding site [chemical binding]; other site 351745007210 active site 351745007211 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 351745007212 UbiA prenyltransferase family; Region: UbiA; pfam01040 351745007213 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 351745007214 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 351745007215 putative active site [active] 351745007216 metal binding site [ion binding]; metal-binding site 351745007217 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745007218 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745007219 LysR substrate binding domain; Region: LysR_substrate; pfam03466 351745007220 dimerization interface [polypeptide binding]; other site 351745007221 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 351745007222 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 351745007223 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 351745007224 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 351745007225 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 351745007226 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 351745007227 acyl-activating enzyme (AAE) consensus motif; other site 351745007228 AMP binding site [chemical binding]; other site 351745007229 active site 351745007230 CoA binding site [chemical binding]; other site 351745007231 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 351745007232 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 351745007233 DNA binding residues [nucleotide binding] 351745007234 putative dimer interface [polypeptide binding]; other site 351745007235 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 351745007236 isovaleryl-CoA dehydrogenase; Region: PLN02519 351745007237 substrate binding site [chemical binding]; other site 351745007238 FAD binding site [chemical binding]; other site 351745007239 catalytic base [active] 351745007240 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 351745007241 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 351745007242 enoyl-CoA hydratase; Provisional; Region: PRK05995 351745007243 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 351745007244 substrate binding site [chemical binding]; other site 351745007245 oxyanion hole (OAH) forming residues; other site 351745007246 trimer interface [polypeptide binding]; other site 351745007247 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 351745007248 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 351745007249 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 351745007250 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 351745007251 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 351745007252 carboxyltransferase (CT) interaction site; other site 351745007253 biotinylation site [posttranslational modification]; other site 351745007254 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 351745007255 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 351745007256 active site 351745007257 catalytic residues [active] 351745007258 metal binding site [ion binding]; metal-binding site 351745007259 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 351745007260 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 351745007261 Putative amidotransferase; Region: DUF4066; pfam13278 351745007262 conserved cys residue [active] 351745007263 Arginine repressor [Transcription]; Region: ArgR; COG1438 351745007264 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 351745007265 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 351745007266 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 351745007267 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 351745007268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745007269 Coenzyme A binding pocket [chemical binding]; other site 351745007270 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 351745007271 Protein export membrane protein; Region: SecD_SecF; cl14618 351745007272 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 351745007273 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 351745007274 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745007275 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 351745007276 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 351745007277 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 351745007278 dihydrodipicolinate synthase; Region: dapA; TIGR00674 351745007279 dimer interface [polypeptide binding]; other site 351745007280 active site 351745007281 catalytic residue [active] 351745007282 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 351745007283 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 351745007284 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 351745007285 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 351745007286 catalytic triad [active] 351745007287 Lysine efflux permease [General function prediction only]; Region: COG1279 351745007288 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 351745007289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745007290 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 351745007291 putative dimerization interface [polypeptide binding]; other site 351745007292 Domain of unknown function DUF20; Region: UPF0118; pfam01594 351745007293 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 351745007294 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 351745007295 CPxP motif; other site 351745007296 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 351745007297 Peptidase family M48; Region: Peptidase_M48; cl12018 351745007298 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 351745007299 binding surface 351745007300 TPR motif; other site 351745007301 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 351745007302 ArsC family; Region: ArsC; pfam03960 351745007303 catalytic residues [active] 351745007304 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 351745007305 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 351745007306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745007307 Walker A motif; other site 351745007308 ATP binding site [chemical binding]; other site 351745007309 Walker B motif; other site 351745007310 arginine finger; other site 351745007311 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 351745007312 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 351745007313 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 351745007314 putative GSH binding site [chemical binding]; other site 351745007315 catalytic residues [active] 351745007316 superoxide dismutase; Provisional; Region: PRK10543 351745007317 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 351745007318 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 351745007319 PrkA family serine protein kinase; Provisional; Region: PRK15455 351745007320 AAA ATPase domain; Region: AAA_16; pfam13191 351745007321 Walker A motif; other site 351745007322 ATP binding site [chemical binding]; other site 351745007323 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 351745007324 hypothetical protein; Provisional; Region: PRK05325 351745007325 SpoVR family protein; Provisional; Region: PRK11767 351745007326 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 351745007327 fatty acid metabolism regulator; Provisional; Region: PRK04984 351745007328 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 351745007329 DNA-binding site [nucleotide binding]; DNA binding site 351745007330 FadR C-terminal domain; Region: FadR_C; pfam07840 351745007331 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 351745007332 disulfide bond formation protein B; Provisional; Region: PRK01749 351745007333 Cache domain; Region: Cache_1; pfam02743 351745007334 PAS fold; Region: PAS_4; pfam08448 351745007335 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745007336 putative active site [active] 351745007337 heme pocket [chemical binding]; other site 351745007338 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 351745007339 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 351745007340 Mg2+ binding site [ion binding]; other site 351745007341 G-X-G motif; other site 351745007342 AMP-binding domain protein; Validated; Region: PRK08315 351745007343 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 351745007344 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 351745007345 acyl-activating enzyme (AAE) consensus motif; other site 351745007346 putative AMP binding site [chemical binding]; other site 351745007347 putative active site [active] 351745007348 putative CoA binding site [chemical binding]; other site 351745007349 Uncharacterized conserved protein [Function unknown]; Region: COG2947 351745007350 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 351745007351 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 351745007352 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 351745007353 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 351745007354 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 351745007355 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 351745007356 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745007357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745007358 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 351745007359 dimerization interface [polypeptide binding]; other site 351745007360 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 351745007361 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 351745007362 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 351745007363 dimer interface [polypeptide binding]; other site 351745007364 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 351745007365 active site 351745007366 Fe binding site [ion binding]; other site 351745007367 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 351745007368 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 351745007369 Protein of unknown function, DUF482; Region: DUF482; pfam04339 351745007370 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 351745007371 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 351745007372 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 351745007373 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 351745007374 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 351745007375 putative FMN binding site [chemical binding]; other site 351745007376 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 351745007377 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 351745007378 Phosphotransferase enzyme family; Region: APH; pfam01636 351745007379 active site 351745007380 ATP binding site [chemical binding]; other site 351745007381 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 351745007382 substrate binding site [chemical binding]; other site 351745007383 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 351745007384 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 351745007385 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745007386 N-terminal plug; other site 351745007387 ligand-binding site [chemical binding]; other site 351745007388 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 351745007389 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 351745007390 ligand binding site [chemical binding]; other site 351745007391 flexible hinge region; other site 351745007392 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 351745007393 putative transporter; Provisional; Region: PRK03699 351745007394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745007395 putative substrate translocation pore; other site 351745007396 purine nucleoside phosphorylase; Provisional; Region: PRK13374 351745007397 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 351745007398 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 351745007399 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 351745007400 putative dimer interface [polypeptide binding]; other site 351745007401 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 351745007402 CoenzymeA binding site [chemical binding]; other site 351745007403 subunit interaction site [polypeptide binding]; other site 351745007404 PHB binding site; other site 351745007405 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 351745007406 CoenzymeA binding site [chemical binding]; other site 351745007407 subunit interaction site [polypeptide binding]; other site 351745007408 PHB binding site; other site 351745007409 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 351745007410 nucleotide binding site/active site [active] 351745007411 HIT family signature motif; other site 351745007412 catalytic residue [active] 351745007413 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 351745007414 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 351745007415 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 351745007416 Protein of unknown function (DUF3802); Region: DUF3802; pfam12290 351745007417 YceI-like domain; Region: YceI; pfam04264 351745007418 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 351745007419 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 351745007420 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 351745007421 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 351745007422 Adenosylmethionine decarboxylase; Region: SAM_decarbox; cl03253 351745007423 arginine decarboxylase; Provisional; Region: PRK05354 351745007424 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 351745007425 dimer interface [polypeptide binding]; other site 351745007426 active site 351745007427 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 351745007428 catalytic residues [active] 351745007429 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 351745007430 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 351745007431 S1 domain; Region: S1_2; pfam13509 351745007432 hypothetical protein; Provisional; Region: PRK11239 351745007433 Protein of unknown function, DUF480; Region: DUF480; pfam04337 351745007434 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 351745007435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745007436 Walker A/P-loop; other site 351745007437 ATP binding site [chemical binding]; other site 351745007438 Q-loop/lid; other site 351745007439 ABC transporter signature motif; other site 351745007440 Walker B; other site 351745007441 D-loop; other site 351745007442 H-loop/switch region; other site 351745007443 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 351745007444 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 351745007445 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 351745007446 GIY-YIG motif/motif A; other site 351745007447 active site 351745007448 catalytic site [active] 351745007449 putative DNA binding site [nucleotide binding]; other site 351745007450 metal binding site [ion binding]; metal-binding site 351745007451 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 351745007452 response regulator; Provisional; Region: PRK09483 351745007453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745007454 active site 351745007455 phosphorylation site [posttranslational modification] 351745007456 intermolecular recognition site; other site 351745007457 dimerization interface [polypeptide binding]; other site 351745007458 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 351745007459 DNA binding residues [nucleotide binding] 351745007460 dimerization interface [polypeptide binding]; other site 351745007461 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 351745007462 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 351745007463 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 351745007464 active site 1 [active] 351745007465 dimer interface [polypeptide binding]; other site 351745007466 active site 2 [active] 351745007467 ribosome modulation factor; Provisional; Region: PRK14563 351745007468 Protein of unknown function (DUF3466); Region: DUF3466; pfam11949 351745007469 ABC transporter ATPase component; Reviewed; Region: PRK11147 351745007470 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 351745007471 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 351745007472 ABC transporter; Region: ABC_tran_2; pfam12848 351745007473 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 351745007474 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 351745007475 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 351745007476 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 351745007477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745007478 S-adenosylmethionine binding site [chemical binding]; other site 351745007479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745007480 S-adenosylmethionine binding site [chemical binding]; other site 351745007481 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 351745007482 HSP70 interaction site [polypeptide binding]; other site 351745007483 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 351745007484 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 351745007485 putative active site [active] 351745007486 putative NTP binding site [chemical binding]; other site 351745007487 putative nucleic acid binding site [nucleotide binding]; other site 351745007488 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 351745007489 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 351745007490 generic binding surface II; other site 351745007491 generic binding surface I; other site 351745007492 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 351745007493 putative active site [active] 351745007494 putative catalytic site [active] 351745007495 putative Mg binding site IVb [ion binding]; other site 351745007496 putative phosphate binding site [ion binding]; other site 351745007497 putative DNA binding site [nucleotide binding]; other site 351745007498 putative Mg binding site IVa [ion binding]; other site 351745007499 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 351745007500 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 351745007501 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 351745007502 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 351745007503 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 351745007504 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 351745007505 substrate binding pocket [chemical binding]; other site 351745007506 membrane-bound complex binding site; other site 351745007507 hinge residues; other site 351745007508 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745007509 Coenzyme A binding pocket [chemical binding]; other site 351745007510 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 351745007511 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 351745007512 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 351745007513 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 351745007514 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 351745007515 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 351745007516 active site 351745007517 Zn binding site [ion binding]; other site 351745007518 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 351745007519 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 351745007520 active site 351745007521 metal binding site [ion binding]; metal-binding site 351745007522 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 351745007523 hypothetical protein; Provisional; Region: PRK03641 351745007524 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829 351745007525 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 351745007526 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 351745007527 binding surface 351745007528 TPR motif; other site 351745007529 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 351745007530 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 351745007531 ligand binding site [chemical binding]; other site 351745007532 translocation protein TolB; Provisional; Region: tolB; PRK04792 351745007533 TolB amino-terminal domain; Region: TolB_N; pfam04052 351745007534 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 351745007535 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 351745007536 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 351745007537 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 351745007538 TolA protein; Region: tolA_full; TIGR02794 351745007539 TolA C-terminal; Region: TolA; pfam06519 351745007540 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 351745007541 TolR protein; Region: tolR; TIGR02801 351745007542 TolQ protein; Region: tolQ; TIGR02796 351745007543 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 351745007544 active site 351745007545 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 351745007546 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 351745007547 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 351745007548 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 351745007549 ligand binding site [chemical binding]; other site 351745007550 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 351745007551 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 351745007552 dimer interface [polypeptide binding]; other site 351745007553 catalytic site [active] 351745007554 putative active site [active] 351745007555 putative substrate binding site [chemical binding]; other site 351745007556 peroxidase; Provisional; Region: PRK15000 351745007557 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 351745007558 dimer interface [polypeptide binding]; other site 351745007559 decamer (pentamer of dimers) interface [polypeptide binding]; other site 351745007560 catalytic triad [active] 351745007561 peroxidatic and resolving cysteines [active] 351745007562 Predicted permease [General function prediction only]; Region: COG2056 351745007563 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 351745007564 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 351745007565 active site 351745007566 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 351745007567 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 351745007568 dimerization interface [polypeptide binding]; other site 351745007569 putative ATP binding site [chemical binding]; other site 351745007570 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 351745007571 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 351745007572 active site 351745007573 substrate binding site [chemical binding]; other site 351745007574 cosubstrate binding site; other site 351745007575 catalytic site [active] 351745007576 UMP phosphatase; Provisional; Region: PRK10444 351745007577 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351745007578 active site 351745007579 motif I; other site 351745007580 motif II; other site 351745007581 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351745007582 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 351745007583 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 351745007584 PA/protease or protease-like domain interface [polypeptide binding]; other site 351745007585 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 351745007586 Peptidase family M28; Region: Peptidase_M28; pfam04389 351745007587 metal binding site [ion binding]; metal-binding site 351745007588 asparagine synthetase B; Provisional; Region: asnB; PRK09431 351745007589 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 351745007590 active site 351745007591 dimer interface [polypeptide binding]; other site 351745007592 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 351745007593 Ligand Binding Site [chemical binding]; other site 351745007594 Molecular Tunnel; other site 351745007595 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 351745007596 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 351745007597 active site 351745007598 nucleophile elbow; other site 351745007599 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 351745007600 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745007601 N-terminal plug; other site 351745007602 ligand-binding site [chemical binding]; other site 351745007603 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 351745007604 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 351745007605 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 351745007606 active site 351745007607 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 351745007608 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 351745007609 active site 351745007610 phosphate binding residues; other site 351745007611 catalytic residues [active] 351745007612 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 351745007613 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 351745007614 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 351745007615 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 351745007616 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 351745007617 dimer interface [polypeptide binding]; other site 351745007618 active site 351745007619 acyl carrier protein; Provisional; Region: acpP; PRK00982 351745007620 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 351745007621 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 351745007622 NAD(P) binding site [chemical binding]; other site 351745007623 homotetramer interface [polypeptide binding]; other site 351745007624 homodimer interface [polypeptide binding]; other site 351745007625 active site 351745007626 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 351745007627 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 351745007628 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 351745007629 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 351745007630 dimer interface [polypeptide binding]; other site 351745007631 active site 351745007632 CoA binding pocket [chemical binding]; other site 351745007633 putative phosphate acyltransferase; Provisional; Region: PRK05331 351745007634 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 351745007635 hypothetical protein; Provisional; Region: PRK11193 351745007636 Maf-like protein; Region: Maf; pfam02545 351745007637 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 351745007638 active site 351745007639 dimer interface [polypeptide binding]; other site 351745007640 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 351745007641 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351745007642 motif II; other site 351745007643 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 351745007644 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 351745007645 RNA binding surface [nucleotide binding]; other site 351745007646 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 351745007647 active site 351745007648 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 351745007649 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 351745007650 homodimer interface [polypeptide binding]; other site 351745007651 oligonucleotide binding site [chemical binding]; other site 351745007652 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 351745007653 DNA-binding site [nucleotide binding]; DNA binding site 351745007654 RNA-binding motif; other site 351745007655 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 351745007656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745007657 S-adenosylmethionine binding site [chemical binding]; other site 351745007658 Phage-related protein, tail component [Function unknown]; Region: COG4733 351745007659 Putative phage tail protein; Region: Phage-tail_3; pfam13550 351745007660 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 351745007661 Interdomain contacts; other site 351745007662 Cytokine receptor motif; other site 351745007663 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 351745007664 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 351745007665 Phage-related protein, tail component [Function unknown]; Region: COG4723 351745007666 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 351745007667 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 351745007668 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 351745007669 Arc-like DNA binding domain; Region: Arc; pfam03869 351745007670 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 351745007671 MPN+ (JAMM) motif; other site 351745007672 Zinc-binding site [ion binding]; other site 351745007673 NlpC/P60 family; Region: NLPC_P60; cl17555 351745007674 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 351745007675 Phage-related protein [Function unknown]; Region: gp18; COG4672 351745007676 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 351745007677 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 351745007678 putative active site [active] 351745007679 putative NTP binding site [chemical binding]; other site 351745007680 putative nucleic acid binding site [nucleotide binding]; other site 351745007681 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 351745007682 four helix bundle protein; Region: TIGR02436 351745007683 Uncharacterized conserved protein [Function unknown]; Region: COG1262 351745007684 Phage minor tail protein; Region: Phage_min_tail; pfam05939 351745007685 Phage-related minor tail protein [Function unknown]; Region: COG5281 351745007686 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 351745007687 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 351745007688 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 351745007689 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 351745007690 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 351745007691 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 351745007692 oligomerization interface [polypeptide binding]; other site 351745007693 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 351745007694 Phage capsid family; Region: Phage_capsid; pfam05065 351745007695 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 351745007696 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 351745007697 oligomer interface [polypeptide binding]; other site 351745007698 active site residues [active] 351745007699 Phage portal protein; Region: Phage_portal; pfam04860 351745007700 Phage-related protein [Function unknown]; Region: COG4695 351745007701 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 351745007702 Phage terminase, small subunit; Region: Terminase_4; pfam05119 351745007703 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 351745007704 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 351745007705 active site 351745007706 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 351745007707 catalytic residue [active] 351745007708 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 351745007709 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 351745007710 active site 351745007711 Int/Topo IB signature motif; other site 351745007712 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 351745007713 uncharacterized phage protein; Region: phage_xxxx; TIGR02642 351745007714 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 351745007715 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 351745007716 non-specific DNA binding site [nucleotide binding]; other site 351745007717 salt bridge; other site 351745007718 sequence-specific DNA binding site [nucleotide binding]; other site 351745007719 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 351745007720 non-specific DNA binding site [nucleotide binding]; other site 351745007721 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 351745007722 salt bridge; other site 351745007723 sequence-specific DNA binding site [nucleotide binding]; other site 351745007724 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 351745007725 Catalytic site [active] 351745007726 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 351745007727 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 351745007728 active site 351745007729 catalytic site [active] 351745007730 substrate binding site [chemical binding]; other site 351745007731 BRCA1 C Terminus (BRCT) domain; Region: BRCT; pfam00533 351745007732 Phage-related protein, tail component [Function unknown]; Region: COG4723 351745007733 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 351745007734 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 351745007735 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 351745007736 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 351745007737 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 351745007738 cofactor binding site; other site 351745007739 DNA binding site [nucleotide binding] 351745007740 substrate interaction site [chemical binding]; other site 351745007741 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 351745007742 HNH endonuclease; Region: HNH_3; pfam13392 351745007743 integrase; Provisional; Region: PRK09692 351745007744 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 351745007745 active site 351745007746 Int/Topo IB signature motif; other site 351745007747 exonuclease I; Provisional; Region: sbcB; PRK11779 351745007748 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 351745007749 active site 351745007750 catalytic site [active] 351745007751 substrate binding site [chemical binding]; other site 351745007752 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 351745007753 cytidine deaminase; Provisional; Region: PRK09027 351745007754 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 351745007755 active site 351745007756 catalytic motif [active] 351745007757 Zn binding site [ion binding]; other site 351745007758 Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211 351745007759 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 351745007760 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 351745007761 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 351745007762 Protein of unknown function (DUF445); Region: DUF445; pfam04286 351745007763 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 351745007764 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 351745007765 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 351745007766 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 351745007767 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 351745007768 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 351745007769 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 351745007770 Predicted membrane protein [Function unknown]; Region: COG3235 351745007771 Uncharacterized conserved protein [Function unknown]; Region: COG2835 351745007772 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 351745007773 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 351745007774 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 351745007775 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 351745007776 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 351745007777 Walker A/P-loop; other site 351745007778 ATP binding site [chemical binding]; other site 351745007779 Q-loop/lid; other site 351745007780 ABC transporter signature motif; other site 351745007781 Walker B; other site 351745007782 D-loop; other site 351745007783 H-loop/switch region; other site 351745007784 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 351745007785 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 351745007786 Competence protein; Region: Competence; pfam03772 351745007787 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 351745007788 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 351745007789 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 351745007790 PilZ domain; Region: PilZ; pfam07238 351745007791 ParA-like protein; Provisional; Region: PHA02518 351745007792 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 351745007793 P-loop; other site 351745007794 Magnesium ion binding site [ion binding]; other site 351745007795 Protein of unknown function (DUF2492); Region: DUF2492; pfam10678 351745007796 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 351745007797 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 351745007798 GAF domain; Region: GAF; pfam01590 351745007799 Histidine kinase; Region: His_kinase; pfam06580 351745007800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745007801 ATP binding site [chemical binding]; other site 351745007802 Mg2+ binding site [ion binding]; other site 351745007803 G-X-G motif; other site 351745007804 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 351745007805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745007806 active site 351745007807 phosphorylation site [posttranslational modification] 351745007808 intermolecular recognition site; other site 351745007809 dimerization interface [polypeptide binding]; other site 351745007810 LytTr DNA-binding domain; Region: LytTR; smart00850 351745007811 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 351745007812 Carbon starvation protein CstA; Region: CstA; pfam02554 351745007813 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 351745007814 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 351745007815 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 351745007816 dimerization interface [polypeptide binding]; other site 351745007817 active site 351745007818 hypothetical protein; Provisional; Region: PRK11020 351745007819 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121 351745007820 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 351745007821 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 351745007822 ATP cone domain; Region: ATP-cone; pfam03477 351745007823 Class III ribonucleotide reductase; Region: RNR_III; cd01675 351745007824 effector binding site; other site 351745007825 active site 351745007826 Zn binding site [ion binding]; other site 351745007827 glycine loop; other site 351745007828 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 351745007829 active site 351745007830 nucleophile elbow; other site 351745007831 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 351745007832 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 351745007833 ATP binding site [chemical binding]; other site 351745007834 Mg++ binding site [ion binding]; other site 351745007835 motif III; other site 351745007836 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745007837 nucleotide binding region [chemical binding]; other site 351745007838 ATP-binding site [chemical binding]; other site 351745007839 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 351745007840 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 351745007841 putative peptidase; Provisional; Region: PRK11649 351745007842 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 351745007843 Peptidase family M23; Region: Peptidase_M23; pfam01551 351745007844 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 351745007845 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 351745007846 Walker A/P-loop; other site 351745007847 ATP binding site [chemical binding]; other site 351745007848 Q-loop/lid; other site 351745007849 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 351745007850 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 351745007851 ABC transporter signature motif; other site 351745007852 Walker B; other site 351745007853 D-loop; other site 351745007854 H-loop/switch region; other site 351745007855 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 351745007856 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 351745007857 active site 351745007858 metal binding site [ion binding]; metal-binding site 351745007859 DNA binding site [nucleotide binding] 351745007860 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 351745007861 hypothetical protein; Provisional; Region: PRK10621 351745007862 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 351745007863 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 351745007864 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745007865 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 351745007866 dimerization interface [polypeptide binding]; other site 351745007867 substrate binding pocket [chemical binding]; other site 351745007868 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 351745007869 Transposase [DNA replication, recombination, and repair]; Region: COG5421 351745007870 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 351745007871 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 351745007872 RNA binding surface [nucleotide binding]; other site 351745007873 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 351745007874 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 351745007875 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 351745007876 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 351745007877 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745007878 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745007879 metal binding site [ion binding]; metal-binding site 351745007880 active site 351745007881 I-site; other site 351745007882 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 351745007883 TPR motif; other site 351745007884 binding surface 351745007885 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 351745007886 binding surface 351745007887 TPR motif; other site 351745007888 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 351745007889 TPR motif; other site 351745007890 binding surface 351745007891 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 351745007892 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 351745007893 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 351745007894 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 351745007895 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 351745007896 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 351745007897 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 351745007898 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 351745007899 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 351745007900 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 351745007901 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 351745007902 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 351745007903 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 351745007904 trimer interface [polypeptide binding]; other site 351745007905 eyelet of channel; other site 351745007906 DNA polymerase II; Reviewed; Region: PRK05762 351745007907 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 351745007908 active site 351745007909 catalytic site [active] 351745007910 substrate binding site [chemical binding]; other site 351745007911 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 351745007912 active site 351745007913 metal-binding site 351745007914 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 351745007915 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 351745007916 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 351745007917 hypothetical protein; Provisional; Region: PRK10621 351745007918 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 351745007919 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 351745007920 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829 351745007921 Late competence development protein ComFB; Region: ComFB; pfam10719 351745007922 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 351745007923 Helix-hairpin-helix motif; Region: HHH; pfam00633 351745007924 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 351745007925 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 351745007926 homodimer interface [polypeptide binding]; other site 351745007927 substrate-cofactor binding pocket; other site 351745007928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745007929 catalytic residue [active] 351745007930 hypothetical protein; Provisional; Region: PRK05415 351745007931 Domain of unknown function (DUF697); Region: DUF697; pfam05128 351745007932 YcjX-like family, DUF463; Region: DUF463; pfam04317 351745007933 phage shock protein C; Region: phageshock_pspC; TIGR02978 351745007934 PspC domain; Region: PspC; cl00864 351745007935 phage shock protein B; Provisional; Region: pspB; PRK09458 351745007936 phage shock protein A; Region: phageshock_pspA; TIGR02977 351745007937 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 351745007938 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745007939 Walker A motif; other site 351745007940 ATP binding site [chemical binding]; other site 351745007941 Walker B motif; other site 351745007942 arginine finger; other site 351745007943 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 351745007944 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 351745007945 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 351745007946 peptide binding site [polypeptide binding]; other site 351745007947 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 351745007948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351745007949 dimer interface [polypeptide binding]; other site 351745007950 conserved gate region; other site 351745007951 putative PBP binding loops; other site 351745007952 ABC-ATPase subunit interface; other site 351745007953 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 351745007954 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 351745007955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351745007956 dimer interface [polypeptide binding]; other site 351745007957 conserved gate region; other site 351745007958 putative PBP binding loops; other site 351745007959 ABC-ATPase subunit interface; other site 351745007960 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170 351745007961 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 351745007962 Walker A/P-loop; other site 351745007963 ATP binding site [chemical binding]; other site 351745007964 Q-loop/lid; other site 351745007965 ABC transporter signature motif; other site 351745007966 Walker B; other site 351745007967 D-loop; other site 351745007968 H-loop/switch region; other site 351745007969 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 351745007970 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167 351745007971 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 351745007972 Walker A/P-loop; other site 351745007973 ATP binding site [chemical binding]; other site 351745007974 Q-loop/lid; other site 351745007975 ABC transporter signature motif; other site 351745007976 Walker B; other site 351745007977 D-loop; other site 351745007978 H-loop/switch region; other site 351745007979 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 351745007980 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 351745007981 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 351745007982 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 351745007983 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 351745007984 periplasmic folding chaperone; Provisional; Region: PRK10788 351745007985 SurA N-terminal domain; Region: SurA_N_3; cl07813 351745007986 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 351745007987 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 351745007988 IHF dimer interface [polypeptide binding]; other site 351745007989 IHF - DNA interface [nucleotide binding]; other site 351745007990 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 351745007991 Found in ATP-dependent protease La (LON); Region: LON; smart00464 351745007992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745007993 Walker A motif; other site 351745007994 ATP binding site [chemical binding]; other site 351745007995 Walker B motif; other site 351745007996 arginine finger; other site 351745007997 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 351745007998 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 351745007999 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 351745008000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745008001 Walker A motif; other site 351745008002 ATP binding site [chemical binding]; other site 351745008003 Walker B motif; other site 351745008004 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 351745008005 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 351745008006 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 351745008007 oligomer interface [polypeptide binding]; other site 351745008008 active site residues [active] 351745008009 trigger factor; Provisional; Region: tig; PRK01490 351745008010 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 351745008011 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 351745008012 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 351745008013 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 351745008014 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 351745008015 homodimer interface [polypeptide binding]; other site 351745008016 NADP binding site [chemical binding]; other site 351745008017 substrate binding site [chemical binding]; other site 351745008018 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 351745008019 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 351745008020 active site 351745008021 HIGH motif; other site 351745008022 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 351745008023 KMSKS motif; other site 351745008024 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 351745008025 tRNA binding surface [nucleotide binding]; other site 351745008026 anticodon binding site; other site 351745008027 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 351745008028 substrate binding site [chemical binding]; other site 351745008029 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 351745008030 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 351745008031 putative active site [active] 351745008032 putative metal binding site [ion binding]; other site 351745008033 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 351745008034 active site 351745008035 dinuclear metal binding site [ion binding]; other site 351745008036 dimerization interface [polypeptide binding]; other site 351745008037 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 351745008038 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 351745008039 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 351745008040 active site 351745008041 HIGH motif; other site 351745008042 nucleotide binding site [chemical binding]; other site 351745008043 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 351745008044 KMSKS motif; other site 351745008045 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 351745008046 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 351745008047 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 351745008048 G1 box; other site 351745008049 GTP/Mg2+ binding site [chemical binding]; other site 351745008050 Switch I region; other site 351745008051 G2 box; other site 351745008052 G3 box; other site 351745008053 Switch II region; other site 351745008054 G4 box; other site 351745008055 G5 box; other site 351745008056 Nucleoside recognition; Region: Gate; pfam07670 351745008057 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 351745008058 Nucleoside recognition; Region: Gate; pfam07670 351745008059 Nucleoside recognition; Region: Gate; pfam07670 351745008060 FeoA domain; Region: FeoA; pfam04023 351745008061 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 351745008062 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 351745008063 heme-binding residues [chemical binding]; other site 351745008064 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 351745008065 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 351745008066 heme-binding residues [chemical binding]; other site 351745008067 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 351745008068 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 351745008069 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 351745008070 Protein of unknown function (DUF3374); Region: DUF3374; pfam11854 351745008071 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 351745008072 putative uracil binding site [chemical binding]; other site 351745008073 putative active site [active] 351745008074 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 351745008075 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 351745008076 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 351745008077 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 351745008078 putative heme binding pocket [chemical binding]; other site 351745008079 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 351745008080 fructuronate transporter; Provisional; Region: PRK10034; cl15264 351745008081 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 351745008082 putative pyridoxal-dependent aspartate 1-decarboxylase; Region: NOD_PanD_pyr; TIGR03799 351745008083 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 351745008084 catalytic residue [active] 351745008085 Transposase, Mutator family; Region: Transposase_mut; pfam00872 351745008086 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 351745008087 Transposase; Region: DEDD_Tnp_IS110; pfam01548 351745008088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 351745008089 Transposase; Region: DEDD_Tnp_IS110; pfam01548 351745008090 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 351745008091 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 351745008092 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 351745008093 trimer interface [polypeptide binding]; other site 351745008094 active site 351745008095 substrate binding site [chemical binding]; other site 351745008096 CoA binding site [chemical binding]; other site 351745008097 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 351745008098 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 351745008099 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 351745008100 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 351745008101 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 351745008102 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 351745008103 Predicted transcriptional regulator [Transcription]; Region: COG2378 351745008104 HTH domain; Region: HTH_11; pfam08279 351745008105 WYL domain; Region: WYL; pfam13280 351745008106 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 351745008107 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 351745008108 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 351745008109 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 351745008110 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 351745008111 active site 351745008112 substrate binding site [chemical binding]; other site 351745008113 metal binding site [ion binding]; metal-binding site 351745008114 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 351745008115 Protein of unknown function (DUF3624); Region: DUF3624; pfam12292 351745008116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 351745008117 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 351745008118 NAD(P) binding site [chemical binding]; other site 351745008119 active site 351745008120 peptide synthase; Provisional; Region: PRK09274 351745008121 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 351745008122 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 351745008123 acyl-activating enzyme (AAE) consensus motif; other site 351745008124 putative AMP binding site [chemical binding]; other site 351745008125 putative active site [active] 351745008126 putative CoA binding site [chemical binding]; other site 351745008127 haloalkane dehalogenase; Provisional; Region: PRK03592 351745008128 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 351745008129 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 351745008130 dimer interface [polypeptide binding]; other site 351745008131 active site 351745008132 CoA binding pocket [chemical binding]; other site 351745008133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745008134 S-adenosylmethionine binding site [chemical binding]; other site 351745008135 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 351745008136 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 351745008137 active site 351745008138 BCCT family transporter; Region: BCCT; pfam02028 351745008139 Protein of unknown function (DUF502); Region: DUF502; pfam04367 351745008140 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 351745008141 dimer interface [polypeptide binding]; other site 351745008142 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 351745008143 metal binding site [ion binding]; metal-binding site 351745008144 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 351745008145 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 351745008146 HAMP domain; Region: HAMP; pfam00672 351745008147 dimerization interface [polypeptide binding]; other site 351745008148 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745008149 dimer interface [polypeptide binding]; other site 351745008150 putative CheW interface [polypeptide binding]; other site 351745008151 transcriptional regulator PhoU; Provisional; Region: PRK11115 351745008152 PhoU domain; Region: PhoU; pfam01895 351745008153 PhoU domain; Region: PhoU; pfam01895 351745008154 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 351745008155 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 351745008156 Walker A/P-loop; other site 351745008157 ATP binding site [chemical binding]; other site 351745008158 Q-loop/lid; other site 351745008159 ABC transporter signature motif; other site 351745008160 Walker B; other site 351745008161 D-loop; other site 351745008162 H-loop/switch region; other site 351745008163 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 351745008164 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 351745008165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351745008166 dimer interface [polypeptide binding]; other site 351745008167 conserved gate region; other site 351745008168 putative PBP binding loops; other site 351745008169 ABC-ATPase subunit interface; other site 351745008170 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 351745008171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351745008172 conserved gate region; other site 351745008173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351745008174 ABC-ATPase subunit interface; other site 351745008175 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 351745008176 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 351745008177 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 351745008178 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 351745008179 Histone chaperone Rttp106-like; Region: Rtt106; pfam08512 351745008180 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 351745008181 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 351745008182 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 351745008183 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 351745008184 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745008185 dimerization interface [polypeptide binding]; other site 351745008186 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745008187 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745008188 dimer interface [polypeptide binding]; other site 351745008189 putative CheW interface [polypeptide binding]; other site 351745008190 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 351745008191 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 351745008192 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 351745008193 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 351745008194 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 351745008195 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 351745008196 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 351745008197 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 351745008198 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 351745008199 Walker A/P-loop; other site 351745008200 ATP binding site [chemical binding]; other site 351745008201 Q-loop/lid; other site 351745008202 ABC transporter signature motif; other site 351745008203 Walker B; other site 351745008204 D-loop; other site 351745008205 H-loop/switch region; other site 351745008206 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 351745008207 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 351745008208 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745008209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 351745008210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 351745008211 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745008212 DNA binding site [nucleotide binding] 351745008213 AAA ATPase domain; Region: AAA_16; pfam13191 351745008214 Domain of unknown function (DUF1888); Region: DUF1888; pfam08985 351745008215 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 351745008216 Transposase; Region: DEDD_Tnp_IS110; pfam01548 351745008217 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 351745008218 PAS domain S-box; Region: sensory_box; TIGR00229 351745008219 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745008220 putative active site [active] 351745008221 heme pocket [chemical binding]; other site 351745008222 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745008223 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745008224 metal binding site [ion binding]; metal-binding site 351745008225 active site 351745008226 I-site; other site 351745008227 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 351745008228 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 351745008229 FAD binding domain; Region: FAD_binding_4; pfam01565 351745008230 Berberine and berberine like; Region: BBE; pfam08031 351745008231 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 351745008232 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 351745008233 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 351745008234 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745008235 Walker A/P-loop; other site 351745008236 ATP binding site [chemical binding]; other site 351745008237 Q-loop/lid; other site 351745008238 ABC transporter signature motif; other site 351745008239 Walker B; other site 351745008240 D-loop; other site 351745008241 H-loop/switch region; other site 351745008242 ABC transporter; Region: ABC_tran_2; pfam12848 351745008243 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 351745008244 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 351745008245 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 351745008246 metal-binding site [ion binding] 351745008247 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 351745008248 Soluble P-type ATPase [General function prediction only]; Region: COG4087 351745008249 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 351745008250 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 351745008251 DNA binding residues [nucleotide binding] 351745008252 dimer interface [polypeptide binding]; other site 351745008253 copper binding site [ion binding]; other site 351745008254 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 351745008255 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 351745008256 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 351745008257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 351745008258 NAD(P) binding site [chemical binding]; other site 351745008259 active site 351745008260 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 351745008261 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 351745008262 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 351745008263 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 351745008264 substrate binding site [chemical binding]; other site 351745008265 oxyanion hole (OAH) forming residues; other site 351745008266 trimer interface [polypeptide binding]; other site 351745008267 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 351745008268 enoyl-CoA hydratase; Provisional; Region: PRK09076 351745008269 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 351745008270 substrate binding site [chemical binding]; other site 351745008271 oxyanion hole (OAH) forming residues; other site 351745008272 trimer interface [polypeptide binding]; other site 351745008273 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 351745008274 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 351745008275 active site 351745008276 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 351745008277 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 351745008278 tetrameric interface [polypeptide binding]; other site 351745008279 NAD binding site [chemical binding]; other site 351745008280 catalytic residues [active] 351745008281 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 351745008282 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 351745008283 dimer interface [polypeptide binding]; other site 351745008284 active site 351745008285 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 351745008286 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 351745008287 HAMP domain; Region: HAMP; pfam00672 351745008288 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745008289 dimer interface [polypeptide binding]; other site 351745008290 putative CheW interface [polypeptide binding]; other site 351745008291 homoserine O-succinyltransferase; Provisional; Region: PRK05368 351745008292 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 351745008293 proposed active site lysine [active] 351745008294 conserved cys residue [active] 351745008295 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 351745008296 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 351745008297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 351745008298 NAD(P) binding site [chemical binding]; other site 351745008299 active site 351745008300 outer membrane protein W; Provisional; Region: PRK10959 351745008301 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 351745008302 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 351745008303 maleylacetoacetate isomerase; Region: maiA; TIGR01262 351745008304 C-terminal domain interface [polypeptide binding]; other site 351745008305 GSH binding site (G-site) [chemical binding]; other site 351745008306 putative dimer interface [polypeptide binding]; other site 351745008307 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 351745008308 dimer interface [polypeptide binding]; other site 351745008309 N-terminal domain interface [polypeptide binding]; other site 351745008310 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 351745008311 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 351745008312 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 351745008313 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 351745008314 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 351745008315 putative aromatic amino acid binding site; other site 351745008316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745008317 Walker A motif; other site 351745008318 ATP binding site [chemical binding]; other site 351745008319 Walker B motif; other site 351745008320 arginine finger; other site 351745008321 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 351745008322 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 351745008323 aromatic arch; other site 351745008324 DCoH dimer interaction site [polypeptide binding]; other site 351745008325 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 351745008326 DCoH tetramer interaction site [polypeptide binding]; other site 351745008327 substrate binding site [chemical binding]; other site 351745008328 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 351745008329 cofactor binding site; other site 351745008330 metal binding site [ion binding]; metal-binding site 351745008331 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 351745008332 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 351745008333 active site 351745008334 tetramer interface; other site 351745008335 UDP-glucose 4-epimerase; Region: PLN02240 351745008336 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 351745008337 NAD binding site [chemical binding]; other site 351745008338 homodimer interface [polypeptide binding]; other site 351745008339 active site 351745008340 substrate binding site [chemical binding]; other site 351745008341 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 351745008342 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 351745008343 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 351745008344 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745008345 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745008346 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 351745008347 dimerization interface [polypeptide binding]; other site 351745008348 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 351745008349 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 351745008350 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 351745008351 Family description; Region: VCBS; pfam13517 351745008352 Family description; Region: VCBS; pfam13517 351745008353 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 351745008354 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 351745008355 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 351745008356 active site 351745008357 catalytic residues [active] 351745008358 DNA binding site [nucleotide binding] 351745008359 Int/Topo IB signature motif; other site 351745008360 Protein of unknown function (DUF2982); Region: DUF2982; pfam11201 351745008361 Uncharacterized conserved protein [Function unknown]; Region: COG1434 351745008362 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 351745008363 putative active site [active] 351745008364 fructokinase; Reviewed; Region: PRK09557 351745008365 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 351745008366 nucleotide binding site [chemical binding]; other site 351745008367 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 351745008368 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 351745008369 active site 351745008370 putative hydrolase; Validated; Region: PRK09248 351745008371 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 351745008372 active site 351745008373 SWIM zinc finger; Region: SWIM; pfam04434 351745008374 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 351745008375 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351745008376 ATP binding site [chemical binding]; other site 351745008377 putative Mg++ binding site [ion binding]; other site 351745008378 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745008379 nucleotide binding region [chemical binding]; other site 351745008380 ATP-binding site [chemical binding]; other site 351745008381 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 351745008382 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 351745008383 DNA-binding site [nucleotide binding]; DNA binding site 351745008384 RNA-binding motif; other site 351745008385 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745008386 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745008387 metal binding site [ion binding]; metal-binding site 351745008388 active site 351745008389 I-site; other site 351745008390 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 351745008391 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 351745008392 Ligand Binding Site [chemical binding]; other site 351745008393 TilS substrate binding domain; Region: TilS; pfam09179 351745008394 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 351745008395 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 351745008396 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 351745008397 putative active site [active] 351745008398 putative PHP Thumb interface [polypeptide binding]; other site 351745008399 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 351745008400 generic binding surface II; other site 351745008401 generic binding surface I; other site 351745008402 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 351745008403 RNA/DNA hybrid binding site [nucleotide binding]; other site 351745008404 active site 351745008405 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 351745008406 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 351745008407 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 351745008408 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 351745008409 active site 351745008410 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 351745008411 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 351745008412 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 351745008413 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 351745008414 trimer interface [polypeptide binding]; other site 351745008415 active site 351745008416 UDP-GlcNAc binding site [chemical binding]; other site 351745008417 lipid binding site [chemical binding]; lipid-binding site 351745008418 periplasmic chaperone; Provisional; Region: PRK10780 351745008419 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 351745008420 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 351745008421 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 351745008422 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 351745008423 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 351745008424 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 351745008425 Surface antigen; Region: Bac_surface_Ag; pfam01103 351745008426 zinc metallopeptidase RseP; Provisional; Region: PRK10779 351745008427 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 351745008428 active site 351745008429 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 351745008430 protein binding site [polypeptide binding]; other site 351745008431 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 351745008432 protein binding site [polypeptide binding]; other site 351745008433 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 351745008434 putative substrate binding region [chemical binding]; other site 351745008435 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 351745008436 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 351745008437 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 351745008438 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 351745008439 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 351745008440 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 351745008441 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 351745008442 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 351745008443 catalytic residue [active] 351745008444 putative FPP diphosphate binding site; other site 351745008445 putative FPP binding hydrophobic cleft; other site 351745008446 dimer interface [polypeptide binding]; other site 351745008447 putative IPP diphosphate binding site; other site 351745008448 ribosome recycling factor; Reviewed; Region: frr; PRK00083 351745008449 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 351745008450 hinge region; other site 351745008451 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 351745008452 putative nucleotide binding site [chemical binding]; other site 351745008453 uridine monophosphate binding site [chemical binding]; other site 351745008454 homohexameric interface [polypeptide binding]; other site 351745008455 elongation factor Ts; Provisional; Region: tsf; PRK09377 351745008456 UBA/TS-N domain; Region: UBA; pfam00627 351745008457 Elongation factor TS; Region: EF_TS; pfam00889 351745008458 Elongation factor TS; Region: EF_TS; pfam00889 351745008459 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 351745008460 rRNA interaction site [nucleotide binding]; other site 351745008461 S8 interaction site; other site 351745008462 putative laminin-1 binding site; other site 351745008463 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 351745008464 active site 351745008465 PII uridylyl-transferase; Provisional; Region: PRK05007 351745008466 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 351745008467 metal binding triad; other site 351745008468 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 351745008469 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 351745008470 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 351745008471 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 351745008472 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 351745008473 trimer interface [polypeptide binding]; other site 351745008474 active site 351745008475 substrate binding site [chemical binding]; other site 351745008476 CoA binding site [chemical binding]; other site 351745008477 PAS domain; Region: PAS_9; pfam13426 351745008478 GAF domain; Region: GAF_2; pfam13185 351745008479 GAF domain; Region: GAF; pfam01590 351745008480 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 351745008481 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 351745008482 Zn2+ binding site [ion binding]; other site 351745008483 Mg2+ binding site [ion binding]; other site 351745008484 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 351745008485 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 351745008486 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 351745008487 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 351745008488 putative active site [active] 351745008489 putative substrate binding site [chemical binding]; other site 351745008490 putative cosubstrate binding site; other site 351745008491 catalytic site [active] 351745008492 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 351745008493 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 351745008494 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 351745008495 active site turn [active] 351745008496 phosphorylation site [posttranslational modification] 351745008497 flavodoxin; Provisional; Region: PRK08105 351745008498 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 351745008499 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 351745008500 probable active site [active] 351745008501 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 351745008502 Protein of unknown function (DUF3549); Region: DUF3549; pfam12069 351745008503 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 351745008504 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 351745008505 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 351745008506 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 351745008507 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; pfam10071 351745008508 SecY interacting protein Syd; Provisional; Region: PRK04968 351745008509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 351745008510 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 351745008511 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 351745008512 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 351745008513 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 351745008514 Winged helix-turn helix; Region: HTH_29; pfam13551 351745008515 Homeodomain-like domain; Region: HTH_23; pfam13384 351745008516 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 351745008517 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 351745008518 active site 351745008519 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 351745008520 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 351745008521 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 351745008522 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 351745008523 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 351745008524 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 351745008525 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 351745008526 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 351745008527 putative NADP binding site [chemical binding]; other site 351745008528 active site 351745008529 Acyl transferase domain; Region: Acyl_transf_1; cl08282 351745008530 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 351745008531 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 351745008532 active site 351745008533 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 351745008534 active site 351745008535 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 351745008536 active site 2 [active] 351745008537 dimer interface [polypeptide binding]; other site 351745008538 active site 1 [active] 351745008539 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 351745008540 active site 1 [active] 351745008541 dimer interface [polypeptide binding]; other site 351745008542 active site 2 [active] 351745008543 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 351745008544 FMN binding site [chemical binding]; other site 351745008545 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 351745008546 substrate binding site [chemical binding]; other site 351745008547 putative catalytic residue [active] 351745008548 hypothetical protein; Provisional; Region: PRK12361 351745008549 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 351745008550 active site 351745008551 catalytic residues [active] 351745008552 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 351745008553 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 351745008554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745008555 Walker A motif; other site 351745008556 ATP binding site [chemical binding]; other site 351745008557 Walker B motif; other site 351745008558 arginine finger; other site 351745008559 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 351745008560 BON domain; Region: BON; pfam04972 351745008561 BON domain; Region: BON; pfam04972 351745008562 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 351745008563 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 351745008564 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745008565 dimerization interface [polypeptide binding]; other site 351745008566 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745008567 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745008568 dimer interface [polypeptide binding]; other site 351745008569 putative CheW interface [polypeptide binding]; other site 351745008570 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 351745008571 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 351745008572 putative active site [active] 351745008573 Zn binding site [ion binding]; other site 351745008574 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 351745008575 MarR family; Region: MarR; pfam01047 351745008576 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 351745008577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745008578 putative substrate translocation pore; other site 351745008579 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 351745008580 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 351745008581 PhnA protein; Region: PhnA; pfam03831 351745008582 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 351745008583 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745008584 N-terminal plug; other site 351745008585 ligand-binding site [chemical binding]; other site 351745008586 TIGR02453 family protein; Region: TIGR02453 351745008587 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 351745008588 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 351745008589 C-terminal domain interface [polypeptide binding]; other site 351745008590 GSH binding site (G-site) [chemical binding]; other site 351745008591 dimer interface [polypeptide binding]; other site 351745008592 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 351745008593 N-terminal domain interface [polypeptide binding]; other site 351745008594 putative dimer interface [polypeptide binding]; other site 351745008595 active site 351745008596 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 351745008597 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 351745008598 YfaZ precursor; Region: YfaZ; pfam07437 351745008599 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 351745008600 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 351745008601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745008602 Coenzyme A binding pocket [chemical binding]; other site 351745008603 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 351745008604 MgtE intracellular N domain; Region: MgtE_N; smart00924 351745008605 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 351745008606 Divalent cation transporter; Region: MgtE; cl00786 351745008607 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 351745008608 catalytic residues [active] 351745008609 dimer interface [polypeptide binding]; other site 351745008610 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 351745008611 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 351745008612 active site 351745008613 Zn binding site [ion binding]; other site 351745008614 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 351745008615 PBP superfamily domain; Region: PBP_like_2; cl17296 351745008616 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 351745008617 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 351745008618 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745008619 putative active site [active] 351745008620 heme pocket [chemical binding]; other site 351745008621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745008622 dimer interface [polypeptide binding]; other site 351745008623 phosphorylation site [posttranslational modification] 351745008624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745008625 ATP binding site [chemical binding]; other site 351745008626 Mg2+ binding site [ion binding]; other site 351745008627 G-X-G motif; other site 351745008628 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 351745008629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745008630 active site 351745008631 phosphorylation site [posttranslational modification] 351745008632 intermolecular recognition site; other site 351745008633 dimerization interface [polypeptide binding]; other site 351745008634 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745008635 DNA binding site [nucleotide binding] 351745008636 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 351745008637 trimer interface [polypeptide binding]; other site 351745008638 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 351745008639 eyelet of channel; other site 351745008640 recombination associated protein; Reviewed; Region: rdgC; PRK00321 351745008641 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 351745008642 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 351745008643 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 351745008644 protein binding site [polypeptide binding]; other site 351745008645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 351745008646 binding surface 351745008647 TPR motif; other site 351745008648 Tetratricopeptide repeat; Region: TPR_12; pfam13424 351745008649 Tetratricopeptide repeat; Region: TPR_12; pfam13424 351745008650 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745008651 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745008652 metal binding site [ion binding]; metal-binding site 351745008653 active site 351745008654 I-site; other site 351745008655 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 351745008656 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 351745008657 flap endonuclease-like protein; Provisional; Region: PRK09482 351745008658 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 351745008659 active site 351745008660 metal binding site 1 [ion binding]; metal-binding site 351745008661 putative 5' ssDNA interaction site; other site 351745008662 metal binding site 3; metal-binding site 351745008663 metal binding site 2 [ion binding]; metal-binding site 351745008664 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 351745008665 putative DNA binding site [nucleotide binding]; other site 351745008666 putative metal binding site [ion binding]; other site 351745008667 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 351745008668 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 351745008669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 351745008670 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 351745008671 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 351745008672 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 351745008673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 351745008674 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 351745008675 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 351745008676 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 351745008677 isocitrate dehydrogenase; Provisional; Region: PRK08997 351745008678 tartrate dehydrogenase; Region: TTC; TIGR02089 351745008679 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 351745008680 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 351745008681 Protein of unknown function (DUF423); Region: DUF423; pfam04241 351745008682 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 351745008683 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 351745008684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745008685 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 351745008686 dimerization interface [polypeptide binding]; other site 351745008687 substrate binding pocket [chemical binding]; other site 351745008688 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 351745008689 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 351745008690 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 351745008691 Ligand Binding Site [chemical binding]; other site 351745008692 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 351745008693 active site residue [active] 351745008694 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 351745008695 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 351745008696 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 351745008697 ligand binding site [chemical binding]; other site 351745008698 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 351745008699 flagellar motor protein PomA; Reviewed; Region: PRK08990 351745008700 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 351745008701 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 351745008702 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 351745008703 substrate binding pocket [chemical binding]; other site 351745008704 chain length determination region; other site 351745008705 substrate-Mg2+ binding site; other site 351745008706 catalytic residues [active] 351745008707 aspartate-rich region 1; other site 351745008708 active site lid residues [active] 351745008709 aspartate-rich region 2; other site 351745008710 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 351745008711 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 351745008712 TPP-binding site; other site 351745008713 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 351745008714 PYR/PP interface [polypeptide binding]; other site 351745008715 dimer interface [polypeptide binding]; other site 351745008716 TPP binding site [chemical binding]; other site 351745008717 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 351745008718 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 351745008719 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 351745008720 dimer interface [polypeptide binding]; other site 351745008721 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 351745008722 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 351745008723 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 351745008724 L-lactate permease; Region: Lactate_perm; cl00701 351745008725 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 351745008726 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 351745008727 FAD binding domain; Region: FAD_binding_4; pfam01565 351745008728 4Fe-4S binding domain; Region: Fer4; pfam00037 351745008729 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 351745008730 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 351745008731 Cysteine-rich domain; Region: CCG; pfam02754 351745008732 Cysteine-rich domain; Region: CCG; pfam02754 351745008733 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 351745008734 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 351745008735 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 351745008736 This domain is found at the N terminal of the mitochondrial ATPase BSC1. It encodes the import and intramitochondrial sorting for the protein; Region: BCS1_N; smart01024 351745008737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 351745008738 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 351745008739 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 351745008740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745008741 Major Facilitator Superfamily; Region: MFS_1; pfam07690 351745008742 putative substrate translocation pore; other site 351745008743 Protein of unknown function (DUF3087); Region: DUF3087; pfam11286 351745008744 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 351745008745 substrate binding pocket [chemical binding]; other site 351745008746 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 351745008747 membrane-bound complex binding site; other site 351745008748 hinge residues; other site 351745008749 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 351745008750 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 351745008751 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 351745008752 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 351745008753 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 351745008754 ATP binding site [chemical binding]; other site 351745008755 Mg++ binding site [ion binding]; other site 351745008756 motif III; other site 351745008757 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745008758 nucleotide binding region [chemical binding]; other site 351745008759 ATP-binding site [chemical binding]; other site 351745008760 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 351745008761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745008762 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 351745008763 putative active site [active] 351745008764 heme pocket [chemical binding]; other site 351745008765 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745008766 PAS domain; Region: PAS_9; pfam13426 351745008767 putative active site [active] 351745008768 heme pocket [chemical binding]; other site 351745008769 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745008770 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745008771 metal binding site [ion binding]; metal-binding site 351745008772 active site 351745008773 I-site; other site 351745008774 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745008775 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 351745008776 glycogen/starch synthase, ADP-glucose type; Region: glgA; TIGR02095 351745008777 ADP-binding pocket [chemical binding]; other site 351745008778 homodimer interface [polypeptide binding]; other site 351745008779 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 351745008780 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 351745008781 ligand binding site; other site 351745008782 oligomer interface; other site 351745008783 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 351745008784 dimer interface [polypeptide binding]; other site 351745008785 N-terminal domain interface [polypeptide binding]; other site 351745008786 sulfate 1 binding site; other site 351745008787 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 351745008788 homodimer interface [polypeptide binding]; other site 351745008789 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 351745008790 active site pocket [active] 351745008791 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 351745008792 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 351745008793 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 351745008794 active site 351745008795 catalytic site [active] 351745008796 glycogen branching enzyme; Provisional; Region: PRK05402 351745008797 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 351745008798 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 351745008799 active site 351745008800 catalytic site [active] 351745008801 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 351745008802 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 351745008803 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 351745008804 active site 351745008805 Transcriptional regulators [Transcription]; Region: MarR; COG1846 351745008806 MarR family; Region: MarR; pfam01047 351745008807 MarR family; Region: MarR_2; cl17246 351745008808 putative alcohol dehydrogenase; Provisional; Region: PRK09860 351745008809 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 351745008810 dimer interface [polypeptide binding]; other site 351745008811 active site 351745008812 metal binding site [ion binding]; metal-binding site 351745008813 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 351745008814 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 351745008815 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 351745008816 isocitrate lyase; Provisional; Region: PRK15063 351745008817 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 351745008818 tetramer interface [polypeptide binding]; other site 351745008819 active site 351745008820 Mg2+/Mn2+ binding site [ion binding]; other site 351745008821 malate synthase A; Region: malate_syn_A; TIGR01344 351745008822 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 351745008823 active site 351745008824 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 351745008825 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745008826 N-terminal plug; other site 351745008827 ligand-binding site [chemical binding]; other site 351745008828 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 351745008829 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 351745008830 TrkA-N domain; Region: TrkA_N; pfam02254 351745008831 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 351745008832 Transposase [DNA replication, recombination, and repair]; Region: COG5421 351745008833 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745008834 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745008835 metal binding site [ion binding]; metal-binding site 351745008836 active site 351745008837 I-site; other site 351745008838 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 351745008839 active site 351745008840 SAM binding site [chemical binding]; other site 351745008841 homodimer interface [polypeptide binding]; other site 351745008842 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 351745008843 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 351745008844 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 351745008845 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 351745008846 putative coenzyme Q binding site [chemical binding]; other site 351745008847 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 351745008848 SmpB-tmRNA interface; other site 351745008849 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 351745008850 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 351745008851 Baseplate J-like protein; Region: Baseplate_J; cl01294 351745008852 Protein of unknown function (DUF2590); Region: DUF2590; pfam10761 351745008853 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 351745008854 Protein of unknown function (DUF2765); Region: DUF2765; pfam10963 351745008855 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 351745008856 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 351745008857 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 351745008858 Protein of unknown function (DUF2597); Region: DUF2597; pfam10772 351745008859 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 351745008860 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 351745008861 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 351745008862 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 351745008863 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 351745008864 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 351745008865 terminase ATPase subunit; Provisional; Region: P; PHA02535 351745008866 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 351745008867 Phage-related protein [Function unknown]; Region: COG4695; cl01923 351745008868 Phage portal protein; Region: Phage_portal; pfam04860 351745008869 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 351745008870 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 351745008871 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 351745008872 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 351745008873 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 351745008874 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 351745008875 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 351745008876 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 351745008877 integrase; Provisional; Region: int; PHA02601 351745008878 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 351745008879 active site 351745008880 DNA binding site [nucleotide binding] 351745008881 Int/Topo IB signature motif; other site 351745008882 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 351745008883 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 351745008884 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 351745008885 Ligand Binding Site [chemical binding]; other site 351745008886 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 351745008887 Ligand Binding Site [chemical binding]; other site 351745008888 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 351745008889 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 351745008890 Sulfate transporter family; Region: Sulfate_transp; pfam00916 351745008891 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 351745008892 Major Facilitator Superfamily; Region: MFS_1; pfam07690 351745008893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745008894 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 351745008895 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 351745008896 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 351745008897 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 351745008898 Predicted permeases [General function prediction only]; Region: COG0701 351745008899 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 351745008900 dimerization interface [polypeptide binding]; other site 351745008901 putative DNA binding site [nucleotide binding]; other site 351745008902 putative Zn2+ binding site [ion binding]; other site 351745008903 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 351745008904 Low molecular weight phosphatase family; Region: LMWPc; cd00115 351745008905 active site 351745008906 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 351745008907 dimerization interface [polypeptide binding]; other site 351745008908 putative DNA binding site [nucleotide binding]; other site 351745008909 putative Zn2+ binding site [ion binding]; other site 351745008910 Predicted permeases [General function prediction only]; Region: COG0701 351745008911 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 351745008912 sequence-specific DNA binding site [nucleotide binding]; other site 351745008913 salt bridge; other site 351745008914 Predicted transcriptional regulator [Transcription]; Region: COG2932 351745008915 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 351745008916 Catalytic site [active] 351745008917 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 351745008918 Helix-turn-helix domain; Region: HTH_17; cl17695 351745008919 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 351745008920 Integrase core domain; Region: rve; pfam00665 351745008921 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 351745008922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 351745008923 AAA domain; Region: AAA_22; pfam13401 351745008924 Walker A motif; other site 351745008925 ATP binding site [chemical binding]; other site 351745008926 Walker B motif; other site 351745008927 arginine finger; other site 351745008928 non-specific DNA binding site [nucleotide binding]; other site 351745008929 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 351745008930 salt bridge; other site 351745008931 sequence-specific DNA binding site [nucleotide binding]; other site 351745008932 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 351745008933 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; pfam10124 351745008934 Mor transcription activator family; Region: Mor; cl02360 351745008935 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 351745008936 Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily; Region: eu-GS; cl00170 351745008937 glutathione (GSH) binding pocket [chemical binding]; other site 351745008938 active site residues [active] 351745008939 ATP binding pocket [chemical binding]; other site 351745008940 magnesium binding site [ion binding]; other site 351745008941 glycine rich loop; other site 351745008942 alanine rich loop; other site 351745008943 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 351745008944 4Fe-4S binding domain; Region: Fer4; pfam00037 351745008945 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 351745008946 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 351745008947 molybdopterin cofactor binding site; other site 351745008948 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 351745008949 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 351745008950 putative molybdopterin cofactor binding site; other site 351745008951 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 351745008952 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 351745008953 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 351745008954 P loop; other site 351745008955 Nucleotide binding site [chemical binding]; other site 351745008956 DTAP/Switch II; other site 351745008957 Switch I; other site 351745008958 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 351745008959 P loop; other site 351745008960 Nucleotide binding site [chemical binding]; other site 351745008961 DTAP/Switch II; other site 351745008962 Switch I; other site 351745008963 arsenical pump membrane protein; Provisional; Region: PRK15445 351745008964 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 351745008965 transmembrane helices; other site 351745008966 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 351745008967 ArsC family; Region: ArsC; pfam03960 351745008968 catalytic residues [active] 351745008969 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 351745008970 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 351745008971 dimerization interface [polypeptide binding]; other site 351745008972 putative DNA binding site [nucleotide binding]; other site 351745008973 putative Zn2+ binding site [ion binding]; other site 351745008974 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 351745008975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 351745008976 YheO-like PAS domain; Region: PAS_6; pfam08348 351745008977 HTH domain; Region: HTH_22; pfam13309 351745008978 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 351745008979 Domain of unknown function (DUF368); Region: DUF368; pfam04018 351745008980 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 351745008981 CoenzymeA binding site [chemical binding]; other site 351745008982 subunit interaction site [polypeptide binding]; other site 351745008983 PHB binding site; other site 351745008984 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 351745008985 nucleoside/Zn binding site; other site 351745008986 dimer interface [polypeptide binding]; other site 351745008987 catalytic motif [active] 351745008988 Predicted membrane protein [Function unknown]; Region: COG2311 351745008989 Protein of unknown function (DUF418); Region: DUF418; cl12135 351745008990 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 351745008991 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 351745008992 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 351745008993 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 351745008994 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 351745008995 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 351745008996 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 351745008997 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 351745008998 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 351745008999 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 351745009000 active site 351745009001 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745009002 PAS fold; Region: PAS_3; pfam08447 351745009003 putative active site [active] 351745009004 heme pocket [chemical binding]; other site 351745009005 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 351745009006 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745009007 dimer interface [polypeptide binding]; other site 351745009008 putative CheW interface [polypeptide binding]; other site 351745009009 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 351745009010 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 351745009011 ATP binding site [chemical binding]; other site 351745009012 Mg++ binding site [ion binding]; other site 351745009013 motif III; other site 351745009014 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745009015 nucleotide binding region [chemical binding]; other site 351745009016 ATP-binding site [chemical binding]; other site 351745009017 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 351745009018 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 351745009019 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 351745009020 intracellular protease, PfpI family; Region: PfpI; TIGR01382 351745009021 conserved cys residue [active] 351745009022 hypothetical protein; Provisional; Region: PRK09947 351745009023 putative oxidoreductase; Provisional; Region: PRK09849 351745009024 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 351745009025 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 351745009026 hypothetical protein; Provisional; Region: PRK09898 351745009027 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 351745009028 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 351745009029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 351745009030 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 351745009031 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 351745009032 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 351745009033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745009034 Coenzyme A binding pocket [chemical binding]; other site 351745009035 Protein of unknown function, DUF486; Region: DUF486; pfam04342 351745009036 Protein of unknown function (DUF2960); Region: DUF2960; pfam11173 351745009037 RDD family; Region: RDD; pfam06271 351745009038 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 351745009039 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 351745009040 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 351745009041 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 351745009042 multifunctional aminopeptidase A; Provisional; Region: PRK00913 351745009043 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 351745009044 interface (dimer of trimers) [polypeptide binding]; other site 351745009045 Substrate-binding/catalytic site; other site 351745009046 Zn-binding sites [ion binding]; other site 351745009047 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 351745009048 Chorismate mutase type II; Region: CM_2; cl00693 351745009049 Prephenate dehydratase; Region: PDT; pfam00800 351745009050 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 351745009051 putative L-Phe binding site [chemical binding]; other site 351745009052 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 351745009053 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 351745009054 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 351745009055 FAD binding pocket [chemical binding]; other site 351745009056 FAD binding motif [chemical binding]; other site 351745009057 phosphate binding motif [ion binding]; other site 351745009058 beta-alpha-beta structure motif; other site 351745009059 NAD binding pocket [chemical binding]; other site 351745009060 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 351745009061 catalytic loop [active] 351745009062 iron binding site [ion binding]; other site 351745009063 hybrid cluster protein; Provisional; Region: PRK05290 351745009064 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 351745009065 ACS interaction site; other site 351745009066 CODH interaction site; other site 351745009067 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 351745009068 ACS interaction site; other site 351745009069 CODH interaction site; other site 351745009070 metal cluster binding site [ion binding]; other site 351745009071 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 351745009072 Chorismate mutase type II; Region: CM_2; cl00693 351745009073 prephenate dehydrogenase; Validated; Region: PRK08507 351745009074 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 351745009075 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 351745009076 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 351745009077 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 351745009078 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 351745009079 RimM N-terminal domain; Region: RimM; pfam01782 351745009080 PRC-barrel domain; Region: PRC; pfam05239 351745009081 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 351745009082 signal recognition particle protein; Provisional; Region: PRK10867 351745009083 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 351745009084 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 351745009085 P loop; other site 351745009086 GTP binding site [chemical binding]; other site 351745009087 Signal peptide binding domain; Region: SRP_SPB; pfam02978 351745009088 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 351745009089 Domain of unknown function DUF21; Region: DUF21; pfam01595 351745009090 hypothetical protein; Provisional; Region: PRK11573 351745009091 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 351745009092 Transporter associated domain; Region: CorC_HlyC; smart01091 351745009093 Protein of unknown function (DUF962); Region: DUF962; cl01879 351745009094 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 351745009095 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 351745009096 active site 351745009097 hydrophilic channel; other site 351745009098 dimerization interface [polypeptide binding]; other site 351745009099 catalytic residues [active] 351745009100 active site lid [active] 351745009101 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 351745009102 Recombination protein O N terminal; Region: RecO_N; pfam11967 351745009103 Recombination protein O C terminal; Region: RecO_C; pfam02565 351745009104 GTPase Era; Reviewed; Region: era; PRK00089 351745009105 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 351745009106 G1 box; other site 351745009107 GTP/Mg2+ binding site [chemical binding]; other site 351745009108 Switch I region; other site 351745009109 G2 box; other site 351745009110 Switch II region; other site 351745009111 G3 box; other site 351745009112 G4 box; other site 351745009113 G5 box; other site 351745009114 KH domain; Region: KH_2; pfam07650 351745009115 ribonuclease III; Reviewed; Region: rnc; PRK00102 351745009116 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 351745009117 dimerization interface [polypeptide binding]; other site 351745009118 active site 351745009119 metal binding site [ion binding]; metal-binding site 351745009120 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 351745009121 dsRNA binding site [nucleotide binding]; other site 351745009122 signal peptidase I; Provisional; Region: PRK10861 351745009123 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 351745009124 Catalytic site [active] 351745009125 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 351745009126 GTP-binding protein LepA; Provisional; Region: PRK05433 351745009127 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 351745009128 G1 box; other site 351745009129 putative GEF interaction site [polypeptide binding]; other site 351745009130 GTP/Mg2+ binding site [chemical binding]; other site 351745009131 Switch I region; other site 351745009132 G2 box; other site 351745009133 G3 box; other site 351745009134 Switch II region; other site 351745009135 G4 box; other site 351745009136 G5 box; other site 351745009137 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 351745009138 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 351745009139 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 351745009140 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 351745009141 anti-sigma E factor; Provisional; Region: rseB; PRK09455 351745009142 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 351745009143 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 351745009144 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 351745009145 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 351745009146 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 351745009147 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 351745009148 DNA binding residues [nucleotide binding] 351745009149 L-aspartate oxidase; Provisional; Region: PRK09077 351745009150 L-aspartate oxidase; Provisional; Region: PRK06175 351745009151 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 351745009152 Uncharacterized conserved protein [Function unknown]; Region: COG2938 351745009153 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 351745009154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745009155 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 351745009156 dimerization interface [polypeptide binding]; other site 351745009157 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 351745009158 thymidylate synthase; Reviewed; Region: thyA; PRK01827 351745009159 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 351745009160 dimerization interface [polypeptide binding]; other site 351745009161 active site 351745009162 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 351745009163 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 351745009164 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 351745009165 GAF domain; Region: GAF; pfam01590 351745009166 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 351745009167 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 351745009168 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 351745009169 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 351745009170 putative active site [active] 351745009171 Ap4A binding site [chemical binding]; other site 351745009172 nudix motif; other site 351745009173 putative metal binding site [ion binding]; other site 351745009174 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 351745009175 putative DNA-binding cleft [nucleotide binding]; other site 351745009176 putative DNA clevage site; other site 351745009177 molecular lever; other site 351745009178 cyclase homology domain; Region: CHD; cd07302 351745009179 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 351745009180 nucleotidyl binding site; other site 351745009181 metal binding site [ion binding]; metal-binding site 351745009182 dimer interface [polypeptide binding]; other site 351745009183 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745009184 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745009185 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 351745009186 dimerization interface [polypeptide binding]; other site 351745009187 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 351745009188 putative binding surface; other site 351745009189 active site 351745009190 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 351745009191 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351745009192 FeS/SAM binding site; other site 351745009193 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 351745009194 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 351745009195 active site 351745009196 dimer interface [polypeptide binding]; other site 351745009197 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 351745009198 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 351745009199 active site 351745009200 FMN binding site [chemical binding]; other site 351745009201 substrate binding site [chemical binding]; other site 351745009202 3Fe-4S cluster binding site [ion binding]; other site 351745009203 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 351745009204 domain interface; other site 351745009205 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 351745009206 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 351745009207 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 351745009208 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 351745009209 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 351745009210 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 351745009211 Cobalamin biosynthesis protein CobD/CbiB [Coenzyme metabolism]; Region: CbiB; COG1270 351745009212 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 351745009213 hypothetical protein; Provisional; Region: PRK10578 351745009214 UPF0126 domain; Region: UPF0126; pfam03458 351745009215 UPF0126 domain; Region: UPF0126; pfam03458 351745009216 SnoaL-like domain; Region: SnoaL_2; pfam12680 351745009217 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 351745009218 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 351745009219 active site 351745009220 HIGH motif; other site 351745009221 dimer interface [polypeptide binding]; other site 351745009222 KMSKS motif; other site 351745009223 S4 RNA-binding domain; Region: S4; smart00363 351745009224 putative peptidase; Provisional; Region: PRK11649 351745009225 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 351745009226 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 351745009227 Peptidase family M23; Region: Peptidase_M23; pfam01551 351745009228 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 351745009229 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 351745009230 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 351745009231 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 351745009232 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 351745009233 Cl- selectivity filter; other site 351745009234 Cl- binding residues [ion binding]; other site 351745009235 pore gating glutamate residue; other site 351745009236 dimer interface [polypeptide binding]; other site 351745009237 aspartate carbamoyltransferase; Provisional; Region: PRK08192 351745009238 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 351745009239 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 351745009240 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 351745009241 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 351745009242 inhibitor-cofactor binding pocket; inhibition site 351745009243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745009244 catalytic residue [active] 351745009245 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 351745009246 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 351745009247 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 351745009248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745009249 Walker A motif; other site 351745009250 ATP binding site [chemical binding]; other site 351745009251 Walker B motif; other site 351745009252 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 351745009253 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 351745009254 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 351745009255 active site 351745009256 NTP binding site [chemical binding]; other site 351745009257 metal binding triad [ion binding]; metal-binding site 351745009258 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 351745009259 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 351745009260 Zn2+ binding site [ion binding]; other site 351745009261 Mg2+ binding site [ion binding]; other site 351745009262 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 351745009263 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 351745009264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 351745009265 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 351745009266 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 351745009267 catalytic center binding site [active] 351745009268 ATP binding site [chemical binding]; other site 351745009269 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 351745009270 homooctamer interface [polypeptide binding]; other site 351745009271 active site 351745009272 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 351745009273 UGMP family protein; Validated; Region: PRK09604 351745009274 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 351745009275 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 351745009276 Yqey-like protein; Region: YqeY; pfam09424 351745009277 DNA primase; Validated; Region: dnaG; PRK05667 351745009278 CHC2 zinc finger; Region: zf-CHC2; pfam01807 351745009279 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 351745009280 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 351745009281 active site 351745009282 metal binding site [ion binding]; metal-binding site 351745009283 interdomain interaction site; other site 351745009284 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 351745009285 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 351745009286 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 351745009287 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 351745009288 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 351745009289 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 351745009290 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 351745009291 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 351745009292 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 351745009293 DNA binding residues [nucleotide binding] 351745009294 Cache domain; Region: Cache_1; pfam02743 351745009295 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 351745009296 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745009297 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745009298 dimer interface [polypeptide binding]; other site 351745009299 putative CheW interface [polypeptide binding]; other site 351745009300 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 351745009301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745009302 putative substrate translocation pore; other site 351745009303 POT family; Region: PTR2; cl17359 351745009304 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 351745009305 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 351745009306 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 351745009307 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 351745009308 inhibitor-cofactor binding pocket; inhibition site 351745009309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745009310 catalytic residue [active] 351745009311 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 351745009312 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 351745009313 tetramerization interface [polypeptide binding]; other site 351745009314 NAD(P) binding site [chemical binding]; other site 351745009315 catalytic residues [active] 351745009316 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 351745009317 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 351745009318 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 351745009319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351745009320 dimer interface [polypeptide binding]; other site 351745009321 conserved gate region; other site 351745009322 putative PBP binding loops; other site 351745009323 ABC-ATPase subunit interface; other site 351745009324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351745009325 dimer interface [polypeptide binding]; other site 351745009326 conserved gate region; other site 351745009327 putative PBP binding loops; other site 351745009328 ABC-ATPase subunit interface; other site 351745009329 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 351745009330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745009331 Walker A/P-loop; other site 351745009332 ATP binding site [chemical binding]; other site 351745009333 Q-loop/lid; other site 351745009334 ABC transporter signature motif; other site 351745009335 Walker B; other site 351745009336 D-loop; other site 351745009337 H-loop/switch region; other site 351745009338 TOBE domain; Region: TOBE_2; pfam08402 351745009339 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 351745009340 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 351745009341 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 351745009342 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 351745009343 Peptidase C26; Region: Peptidase_C26; pfam07722 351745009344 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 351745009345 catalytic triad [active] 351745009346 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 351745009347 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 351745009348 non-specific DNA binding site [nucleotide binding]; other site 351745009349 salt bridge; other site 351745009350 sequence-specific DNA binding site [nucleotide binding]; other site 351745009351 Cupin domain; Region: Cupin_2; pfam07883 351745009352 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 351745009353 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 351745009354 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 351745009355 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 351745009356 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 351745009357 active site residue [active] 351745009358 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 351745009359 active site 351745009360 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 351745009361 active site residue [active] 351745009362 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 351745009363 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 351745009364 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 351745009365 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 351745009366 NAD(P) binding site [chemical binding]; other site 351745009367 catalytic residues [active] 351745009368 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 351745009369 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 351745009370 inhibitor-cofactor binding pocket; inhibition site 351745009371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745009372 catalytic residue [active] 351745009373 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 351745009374 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 351745009375 tetrameric interface [polypeptide binding]; other site 351745009376 NAD binding site [chemical binding]; other site 351745009377 catalytic residues [active] 351745009378 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 351745009379 conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001 351745009380 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 351745009381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745009382 putative substrate translocation pore; other site 351745009383 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 351745009384 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 351745009385 active site 351745009386 dimer interface [polypeptide binding]; other site 351745009387 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 351745009388 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 351745009389 dimer interface [polypeptide binding]; other site 351745009390 active site 351745009391 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 351745009392 dimer interface [polypeptide binding]; other site 351745009393 active site 351745009394 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 351745009395 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 351745009396 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 351745009397 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 351745009398 active site 351745009399 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 351745009400 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 351745009401 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 351745009402 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 351745009403 Transcriptional regulators [Transcription]; Region: PurR; COG1609 351745009404 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 351745009405 DNA binding site [nucleotide binding] 351745009406 domain linker motif; other site 351745009407 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 351745009408 putative ligand binding site [chemical binding]; other site 351745009409 putative dimerization interface [polypeptide binding]; other site 351745009410 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 351745009411 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 351745009412 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 351745009413 Nitrogen regulatory protein P-II; Region: P-II; smart00938 351745009414 Type II transport protein GspH; Region: GspH; pfam12019 351745009415 Type II transport protein GspH; Region: GspH; pfam12019 351745009416 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 351745009417 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 351745009418 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 351745009419 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 351745009420 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 351745009421 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 351745009422 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 351745009423 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 351745009424 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 351745009425 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 351745009426 lipoprotein signal peptidase; Provisional; Region: PRK14787 351745009427 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 351745009428 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 351745009429 HIGH motif; other site 351745009430 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 351745009431 active site 351745009432 KMSKS motif; other site 351745009433 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 351745009434 tRNA binding surface [nucleotide binding]; other site 351745009435 anticodon binding site; other site 351745009436 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 351745009437 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 351745009438 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 351745009439 active site 351745009440 Riboflavin kinase; Region: Flavokinase; smart00904 351745009441 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 351745009442 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 351745009443 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 351745009444 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 351745009445 dimerization interface [polypeptide binding]; other site 351745009446 putative DNA binding site [nucleotide binding]; other site 351745009447 putative Zn2+ binding site [ion binding]; other site 351745009448 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 351745009449 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 351745009450 PA/protease or protease-like domain interface [polypeptide binding]; other site 351745009451 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 351745009452 Peptidase family M28; Region: Peptidase_M28; pfam04389 351745009453 metal binding site [ion binding]; metal-binding site 351745009454 hypothetical protein; Validated; Region: PRK02101 351745009455 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 351745009456 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 351745009457 putative phosphoketolase; Provisional; Region: PRK05261 351745009458 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 351745009459 TPP-binding site; other site 351745009460 XFP C-terminal domain; Region: XFP_C; pfam09363 351745009461 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 351745009462 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 351745009463 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 351745009464 ligand binding site [chemical binding]; other site 351745009465 transaldolase-like protein; Provisional; Region: PTZ00411 351745009466 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 351745009467 active site 351745009468 dimer interface [polypeptide binding]; other site 351745009469 catalytic residue [active] 351745009470 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 351745009471 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 351745009472 active site 351745009473 dimer interface [polypeptide binding]; other site 351745009474 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 351745009475 dimer interface [polypeptide binding]; other site 351745009476 active site 351745009477 Protein of unknown function (DUF3545); Region: DUF3545; pfam12065 351745009478 Hemerythrin-like domain; Region: Hr-like; cd12108 351745009479 Fe binding site [ion binding]; other site 351745009480 RNA polymerase sigma factor; Provisional; Region: PRK12513 351745009481 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 351745009482 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 351745009483 DNA binding residues [nucleotide binding] 351745009484 von Willebrand factor; Region: vWF_A; pfam12450 351745009485 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 351745009486 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 351745009487 metal ion-dependent adhesion site (MIDAS); other site 351745009488 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 351745009489 putative transporter; Provisional; Region: PRK11660 351745009490 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 351745009491 Sulfate transporter family; Region: Sulfate_transp; pfam00916 351745009492 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 351745009493 AIR carboxylase; Region: AIRC; pfam00731 351745009494 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 351745009495 ATP-grasp domain; Region: ATP-grasp; pfam02222 351745009496 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 351745009497 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 351745009498 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745009499 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745009500 metal binding site [ion binding]; metal-binding site 351745009501 active site 351745009502 I-site; other site 351745009503 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 351745009504 N-acetyl-D-glucosamine binding site [chemical binding]; other site 351745009505 catalytic residue [active] 351745009506 glutamate--cysteine ligase; Provisional; Region: PRK02107 351745009507 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 351745009508 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 351745009509 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 351745009510 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 351745009511 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 351745009512 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 351745009513 Predicted membrane protein [Function unknown]; Region: COG1238 351745009514 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 351745009515 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 351745009516 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 351745009517 oxaloacetate decarboxylase; Provisional; Region: PRK14040 351745009518 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 351745009519 active site 351745009520 catalytic residues [active] 351745009521 metal binding site [ion binding]; metal-binding site 351745009522 homodimer binding site [polypeptide binding]; other site 351745009523 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 351745009524 carboxyltransferase (CT) interaction site; other site 351745009525 biotinylation site [posttranslational modification]; other site 351745009526 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 351745009527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 351745009528 DDE superfamily endonuclease; Region: DDE_3; pfam13358 351745009529 Winged helix-turn helix; Region: HTH_33; pfam13592 351745009530 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 351745009531 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 351745009532 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 351745009533 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 351745009534 Clp amino terminal domain; Region: Clp_N; pfam02861 351745009535 Clp amino terminal domain; Region: Clp_N; pfam02861 351745009536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745009537 Walker A motif; other site 351745009538 ATP binding site [chemical binding]; other site 351745009539 Walker B motif; other site 351745009540 arginine finger; other site 351745009541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745009542 Walker A motif; other site 351745009543 ATP binding site [chemical binding]; other site 351745009544 Walker B motif; other site 351745009545 arginine finger; other site 351745009546 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 351745009547 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 351745009548 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 351745009549 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 351745009550 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 351745009551 RNA binding surface [nucleotide binding]; other site 351745009552 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 351745009553 active site 351745009554 Outer membrane lipoprotein; Region: YfiO; pfam13525 351745009555 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 351745009556 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745009557 dimer interface [polypeptide binding]; other site 351745009558 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 351745009559 putative CheW interface [polypeptide binding]; other site 351745009560 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 351745009561 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 351745009562 RNA binding surface [nucleotide binding]; other site 351745009563 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 351745009564 active site 351745009565 uracil binding [chemical binding]; other site 351745009566 Predicted transcriptional regulator [Transcription]; Region: COG2345 351745009567 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 351745009568 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 351745009569 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 351745009570 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 351745009571 active site 351745009572 metal binding site [ion binding]; metal-binding site 351745009573 YcxB-like protein; Region: YcxB; pfam14317 351745009574 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 351745009575 MltA-interacting protein MipA; Region: MipA; cl01504 351745009576 Protein of unknown function (DUF3019); Region: DUF3019; pfam11456 351745009577 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 351745009578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745009579 active site 351745009580 phosphorylation site [posttranslational modification] 351745009581 intermolecular recognition site; other site 351745009582 dimerization interface [polypeptide binding]; other site 351745009583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745009584 DNA binding site [nucleotide binding] 351745009585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 351745009586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745009587 dimer interface [polypeptide binding]; other site 351745009588 phosphorylation site [posttranslational modification] 351745009589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745009590 ATP binding site [chemical binding]; other site 351745009591 Mg2+ binding site [ion binding]; other site 351745009592 G-X-G motif; other site 351745009593 Predicted Fe-S protein [General function prediction only]; Region: COG3313 351745009594 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 351745009595 cysteine synthase B; Region: cysM; TIGR01138 351745009596 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 351745009597 dimer interface [polypeptide binding]; other site 351745009598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745009599 catalytic residue [active] 351745009600 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CysP; COG4150 351745009601 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 351745009602 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 351745009603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351745009604 dimer interface [polypeptide binding]; other site 351745009605 conserved gate region; other site 351745009606 putative PBP binding loops; other site 351745009607 ABC-ATPase subunit interface; other site 351745009608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351745009609 dimer interface [polypeptide binding]; other site 351745009610 conserved gate region; other site 351745009611 putative PBP binding loops; other site 351745009612 ABC-ATPase subunit interface; other site 351745009613 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 351745009614 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 351745009615 Walker A/P-loop; other site 351745009616 ATP binding site [chemical binding]; other site 351745009617 Q-loop/lid; other site 351745009618 ABC transporter signature motif; other site 351745009619 Walker B; other site 351745009620 D-loop; other site 351745009621 H-loop/switch region; other site 351745009622 TOBE-like domain; Region: TOBE_3; pfam12857 351745009623 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 351745009624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 351745009625 ATP-grasp domain; Region: ATP-grasp; pfam02222 351745009626 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 351745009627 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 351745009628 active site 351745009629 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 351745009630 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 351745009631 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 351745009632 binding surface 351745009633 TPR motif; other site 351745009634 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 351745009635 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 351745009636 putative ligand binding site [chemical binding]; other site 351745009637 putative NAD binding site [chemical binding]; other site 351745009638 catalytic site [active] 351745009639 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 351745009640 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 351745009641 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 351745009642 putative metal binding site [ion binding]; other site 351745009643 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 351745009644 HSP70 interaction site [polypeptide binding]; other site 351745009645 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 351745009646 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 351745009647 Substrate binding site; other site 351745009648 metal-binding site 351745009649 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 351745009650 Phosphotransferase enzyme family; Region: APH; pfam01636 351745009651 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 351745009652 OstA-like protein; Region: OstA; cl00844 351745009653 Organic solvent tolerance protein; Region: OstA_C; pfam04453 351745009654 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 351745009655 SurA N-terminal domain; Region: SurA_N; pfam09312 351745009656 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 351745009657 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 351745009658 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 351745009659 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 351745009660 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 351745009661 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 351745009662 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 351745009663 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 351745009664 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 351745009665 active site 351745009666 metal binding site [ion binding]; metal-binding site 351745009667 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745009668 dimerization interface [polypeptide binding]; other site 351745009669 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745009670 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745009671 dimer interface [polypeptide binding]; other site 351745009672 putative CheW interface [polypeptide binding]; other site 351745009673 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 351745009674 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 351745009675 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 351745009676 NADP+ binding site [chemical binding]; other site 351745009677 folate binding site [chemical binding]; other site 351745009678 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 351745009679 Uncharacterized conserved protein [Function unknown]; Region: COG2966 351745009680 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 351745009681 GTPase CgtA; Reviewed; Region: obgE; PRK12298 351745009682 GTP1/OBG; Region: GTP1_OBG; pfam01018 351745009683 Obg GTPase; Region: Obg; cd01898 351745009684 G1 box; other site 351745009685 GTP/Mg2+ binding site [chemical binding]; other site 351745009686 Switch I region; other site 351745009687 G2 box; other site 351745009688 G3 box; other site 351745009689 Switch II region; other site 351745009690 G4 box; other site 351745009691 G5 box; other site 351745009692 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 351745009693 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 351745009694 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 351745009695 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 351745009696 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 351745009697 substrate binding pocket [chemical binding]; other site 351745009698 chain length determination region; other site 351745009699 substrate-Mg2+ binding site; other site 351745009700 catalytic residues [active] 351745009701 aspartate-rich region 1; other site 351745009702 active site lid residues [active] 351745009703 aspartate-rich region 2; other site 351745009704 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 351745009705 ligand binding site [chemical binding]; other site 351745009706 active site 351745009707 UGI interface [polypeptide binding]; other site 351745009708 catalytic site [active] 351745009709 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 351745009710 LysE type translocator; Region: LysE; cl00565 351745009711 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 351745009712 DsbD alpha interface [polypeptide binding]; other site 351745009713 catalytic residues [active] 351745009714 PAS domain S-box; Region: sensory_box; TIGR00229 351745009715 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745009716 putative active site [active] 351745009717 heme pocket [chemical binding]; other site 351745009718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745009719 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 351745009720 Walker A motif; other site 351745009721 ATP binding site [chemical binding]; other site 351745009722 Walker B motif; other site 351745009723 arginine finger; other site 351745009724 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 351745009725 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 351745009726 4Fe-4S binding domain; Region: Fer4_5; pfam12801 351745009727 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 351745009728 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 351745009729 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 351745009730 acyl-activating enzyme (AAE) consensus motif; other site 351745009731 putative AMP binding site [chemical binding]; other site 351745009732 putative active site [active] 351745009733 putative CoA binding site [chemical binding]; other site 351745009734 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 351745009735 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 351745009736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745009737 Walker A/P-loop; other site 351745009738 ATP binding site [chemical binding]; other site 351745009739 Q-loop/lid; other site 351745009740 ABC transporter signature motif; other site 351745009741 Walker B; other site 351745009742 D-loop; other site 351745009743 H-loop/switch region; other site 351745009744 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 351745009745 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 351745009746 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 351745009747 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 351745009748 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745009749 N-terminal plug; other site 351745009750 ligand-binding site [chemical binding]; other site 351745009751 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 351745009752 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 351745009753 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 351745009754 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 351745009755 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 351745009756 DNA binding residues [nucleotide binding] 351745009757 dimer interface [polypeptide binding]; other site 351745009758 mercury binding site [ion binding]; other site 351745009759 MerT mercuric transport protein; Region: MerT; pfam02411 351745009760 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 351745009761 metal-binding site [ion binding] 351745009762 putative mercuric reductase; Provisional; Region: PRK13748 351745009763 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 351745009764 metal-binding site [ion binding] 351745009765 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 351745009766 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 351745009767 multiple promoter invertase; Provisional; Region: mpi; PRK13413 351745009768 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 351745009769 catalytic residues [active] 351745009770 catalytic nucleophile [active] 351745009771 Presynaptic Site I dimer interface [polypeptide binding]; other site 351745009772 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 351745009773 Synaptic Flat tetramer interface [polypeptide binding]; other site 351745009774 Synaptic Site I dimer interface [polypeptide binding]; other site 351745009775 DNA binding site [nucleotide binding] 351745009776 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 351745009777 DNA-binding interface [nucleotide binding]; DNA binding site 351745009778 Integrase core domain; Region: rve; pfam00665 351745009779 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 351745009780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745009781 Walker A motif; other site 351745009782 ATP binding site [chemical binding]; other site 351745009783 Walker B motif; other site 351745009784 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 351745009785 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 351745009786 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 351745009787 putative hemin binding site; other site 351745009788 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 351745009789 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 351745009790 ABC-ATPase subunit interface; other site 351745009791 dimer interface [polypeptide binding]; other site 351745009792 putative PBP binding regions; other site 351745009793 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 351745009794 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 351745009795 Walker A/P-loop; other site 351745009796 ATP binding site [chemical binding]; other site 351745009797 Q-loop/lid; other site 351745009798 ABC transporter signature motif; other site 351745009799 Walker B; other site 351745009800 D-loop; other site 351745009801 H-loop/switch region; other site 351745009802 Protein of unknown function (DUF2956); Region: DUF2956; pfam11169 351745009803 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294 351745009804 interface (dimer of trimers) [polypeptide binding]; other site 351745009805 Substrate-binding/catalytic site; other site 351745009806 Zn-binding sites [ion binding]; other site 351745009807 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 351745009808 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 351745009809 metal binding site [ion binding]; metal-binding site 351745009810 dimer interface [polypeptide binding]; other site 351745009811 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 351745009812 EamA-like transporter family; Region: EamA; pfam00892 351745009813 EamA-like transporter family; Region: EamA; pfam00892 351745009814 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745009815 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745009816 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 351745009817 putative effector binding pocket; other site 351745009818 dimerization interface [polypeptide binding]; other site 351745009819 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 351745009820 active site 351745009821 DNA polymerase IV; Validated; Region: PRK02406 351745009822 DNA binding site [nucleotide binding] 351745009823 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 351745009824 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745009825 dimerization interface [polypeptide binding]; other site 351745009826 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745009827 dimer interface [polypeptide binding]; other site 351745009828 putative CheW interface [polypeptide binding]; other site 351745009829 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 351745009830 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 351745009831 heme binding site [chemical binding]; other site 351745009832 ferroxidase pore; other site 351745009833 ferroxidase diiron center [ion binding]; other site 351745009834 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 351745009835 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 351745009836 heme binding site [chemical binding]; other site 351745009837 ferroxidase pore; other site 351745009838 ferroxidase diiron center [ion binding]; other site 351745009839 Protein of unknown function (DUF539); Region: DUF539; cl01129 351745009840 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 351745009841 ApbE family; Region: ApbE; pfam02424 351745009842 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 351745009843 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 351745009844 FAD binding pocket [chemical binding]; other site 351745009845 FAD binding motif [chemical binding]; other site 351745009846 phosphate binding motif [ion binding]; other site 351745009847 beta-alpha-beta structure motif; other site 351745009848 NAD binding pocket [chemical binding]; other site 351745009849 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 351745009850 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 351745009851 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 351745009852 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 351745009853 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 351745009854 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 351745009855 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 351745009856 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 351745009857 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 351745009858 S-ribosylhomocysteinase; Provisional; Region: PRK02260 351745009859 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 351745009860 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 351745009861 BolA-like protein; Region: BolA; cl00386 351745009862 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 351745009863 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 351745009864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745009865 S-adenosylmethionine binding site [chemical binding]; other site 351745009866 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 351745009867 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 351745009868 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 351745009869 homodimer interface [polypeptide binding]; other site 351745009870 substrate-cofactor binding pocket; other site 351745009871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745009872 catalytic residue [active] 351745009873 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 351745009874 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 351745009875 DNA-binding site [nucleotide binding]; DNA binding site 351745009876 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 351745009877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745009878 homodimer interface [polypeptide binding]; other site 351745009879 catalytic residue [active] 351745009880 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 351745009881 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 351745009882 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 351745009883 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 351745009884 Helix-turn-helix domain; Region: HTH_18; pfam12833 351745009885 EamA-like transporter family; Region: EamA; pfam00892 351745009886 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 351745009887 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 351745009888 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745009889 dimerization interface [polypeptide binding]; other site 351745009890 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745009891 dimer interface [polypeptide binding]; other site 351745009892 putative CheW interface [polypeptide binding]; other site 351745009893 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 351745009894 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 351745009895 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 351745009896 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 351745009897 RNA binding surface [nucleotide binding]; other site 351745009898 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 351745009899 probable active site [active] 351745009900 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 351745009901 Peptidase S46; Region: Peptidase_S46; pfam10459 351745009902 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 351745009903 yybP-ykoY element as predicted by Rfam (RF00080), score 63.83; riboswitch of unknown function 351745009904 Predicted membrane protein [Function unknown]; Region: COG2119 351745009905 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 351745009906 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 351745009907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 351745009908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 351745009909 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 351745009910 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 351745009911 Rhomboid family; Region: Rhomboid; pfam01694 351745009912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745009913 S-adenosylmethionine binding site [chemical binding]; other site 351745009914 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 351745009915 heme-binding residues [chemical binding]; other site 351745009916 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 351745009917 L-aspartate oxidase; Provisional; Region: PRK06175 351745009918 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 351745009919 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 351745009920 putative ligand binding site [chemical binding]; other site 351745009921 putative NAD binding site [chemical binding]; other site 351745009922 catalytic site [active] 351745009923 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 351745009924 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 351745009925 Mechanosensitive ion channel; Region: MS_channel; pfam00924 351745009926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745009927 multifunctional aminopeptidase A; Provisional; Region: PRK00913 351745009928 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 351745009929 interface (dimer of trimers) [polypeptide binding]; other site 351745009930 Substrate-binding/catalytic site; other site 351745009931 Zn-binding sites [ion binding]; other site 351745009932 peroxiredoxin; Region: AhpC; TIGR03137 351745009933 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 351745009934 dimer interface [polypeptide binding]; other site 351745009935 decamer (pentamer of dimers) interface [polypeptide binding]; other site 351745009936 catalytic triad [active] 351745009937 peroxidatic and resolving cysteines [active] 351745009938 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 351745009939 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 351745009940 catalytic residue [active] 351745009941 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 351745009942 catalytic residues [active] 351745009943 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 351745009944 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 351745009945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745009946 Coenzyme A binding pocket [chemical binding]; other site 351745009947 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 351745009948 DHH family; Region: DHH; pfam01368 351745009949 DHHA1 domain; Region: DHHA1; pfam02272 351745009950 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 351745009951 dimerization domain [polypeptide binding]; other site 351745009952 dimer interface [polypeptide binding]; other site 351745009953 catalytic residues [active] 351745009954 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 351745009955 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 351745009956 active site 351745009957 Int/Topo IB signature motif; other site 351745009958 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 351745009959 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 351745009960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745009961 S-adenosylmethionine binding site [chemical binding]; other site 351745009962 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 351745009963 DEAD-like helicases superfamily; Region: DEXDc; smart00487 351745009964 ATP binding site [chemical binding]; other site 351745009965 Mg++ binding site [ion binding]; other site 351745009966 motif III; other site 351745009967 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745009968 nucleotide binding region [chemical binding]; other site 351745009969 ATP-binding site [chemical binding]; other site 351745009970 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 351745009971 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745009972 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 351745009973 Protein export membrane protein; Region: SecD_SecF; cl14618 351745009974 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 351745009975 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351745009976 FeS/SAM binding site; other site 351745009977 PAS domain; Region: PAS_9; pfam13426 351745009978 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745009979 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 351745009980 DNA binding site [nucleotide binding] 351745009981 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 351745009982 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 351745009983 Protein of unknown function, DUF481; Region: DUF481; pfam04338 351745009984 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 351745009985 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 351745009986 intersubunit interface [polypeptide binding]; other site 351745009987 active site 351745009988 zinc binding site [ion binding]; other site 351745009989 Na+ binding site [ion binding]; other site 351745009990 Phosphoglycerate kinase; Region: PGK; pfam00162 351745009991 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 351745009992 substrate binding site [chemical binding]; other site 351745009993 hinge regions; other site 351745009994 ADP binding site [chemical binding]; other site 351745009995 catalytic site [active] 351745009996 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 351745009997 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 351745009998 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 351745009999 transketolase; Reviewed; Region: PRK12753 351745010000 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 351745010001 TPP-binding site [chemical binding]; other site 351745010002 dimer interface [polypeptide binding]; other site 351745010003 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 351745010004 PYR/PP interface [polypeptide binding]; other site 351745010005 dimer interface [polypeptide binding]; other site 351745010006 TPP binding site [chemical binding]; other site 351745010007 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 351745010008 S-adenosylmethionine synthetase; Validated; Region: PRK05250 351745010009 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 351745010010 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 351745010011 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 351745010012 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 351745010013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 351745010014 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 351745010015 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 351745010016 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 351745010017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 351745010018 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 351745010019 META domain; Region: META; pfam03724 351745010020 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 351745010021 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 351745010022 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 351745010023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745010024 Coenzyme A binding pocket [chemical binding]; other site 351745010025 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 351745010026 serine transporter; Region: stp; TIGR00814 351745010027 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 351745010028 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 351745010029 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 351745010030 active site 351745010031 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 351745010032 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 351745010033 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 351745010034 MarR family; Region: MarR; pfam01047 351745010035 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 351745010036 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745010037 Coenzyme A binding pocket [chemical binding]; other site 351745010038 AAA ATPase domain; Region: AAA_16; pfam13191 351745010039 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 351745010040 Walker A motif; other site 351745010041 ATP binding site [chemical binding]; other site 351745010042 Walker B motif; other site 351745010043 arginine finger; other site 351745010044 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 351745010045 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 351745010046 catalytic loop [active] 351745010047 iron binding site [ion binding]; other site 351745010048 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 351745010049 FAD binding pocket [chemical binding]; other site 351745010050 FAD binding motif [chemical binding]; other site 351745010051 phosphate binding motif [ion binding]; other site 351745010052 beta-alpha-beta structure motif; other site 351745010053 NAD binding pocket [chemical binding]; other site 351745010054 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 351745010055 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 351745010056 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 351745010057 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 351745010058 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 351745010059 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 351745010060 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 351745010061 E3 interaction surface; other site 351745010062 lipoyl attachment site [posttranslational modification]; other site 351745010063 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 351745010064 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 351745010065 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 351745010066 active site 351745010067 catalytic tetrad [active] 351745010068 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 351745010069 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 351745010070 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745010071 dimerization interface [polypeptide binding]; other site 351745010072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745010073 dimer interface [polypeptide binding]; other site 351745010074 phosphorylation site [posttranslational modification] 351745010075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745010076 ATP binding site [chemical binding]; other site 351745010077 Mg2+ binding site [ion binding]; other site 351745010078 G-X-G motif; other site 351745010079 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 351745010080 DNA binding site [nucleotide binding] 351745010081 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 351745010082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745010083 active site 351745010084 phosphorylation site [posttranslational modification] 351745010085 intermolecular recognition site; other site 351745010086 dimerization interface [polypeptide binding]; other site 351745010087 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745010088 DNA binding site [nucleotide binding] 351745010089 Protein of unknown function (DUF3019); Region: DUF3019; pfam11456 351745010090 MltA-interacting protein MipA; Region: MipA; cl01504 351745010091 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 351745010092 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 351745010093 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 351745010094 catalytic residue [active] 351745010095 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 351745010096 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 351745010097 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 351745010098 active site 351745010099 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 351745010100 Cupin domain; Region: Cupin_2; pfam07883 351745010101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 351745010102 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 351745010103 Peptidase family U32; Region: Peptidase_U32; pfam01136 351745010104 Collagenase; Region: DUF3656; pfam12392 351745010105 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 351745010106 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 351745010107 active site 351745010108 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 351745010109 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 351745010110 putative DNA binding site [nucleotide binding]; other site 351745010111 putative Zn2+ binding site [ion binding]; other site 351745010112 AsnC family; Region: AsnC_trans_reg; pfam01037 351745010113 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 351745010114 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 351745010115 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 351745010116 catalytic residues [active] 351745010117 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 351745010118 PA/protease or protease-like domain interface [polypeptide binding]; other site 351745010119 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 351745010120 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 351745010121 inner membrane transport permease; Provisional; Region: PRK15066 351745010122 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 351745010123 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 351745010124 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 351745010125 Walker A/P-loop; other site 351745010126 ATP binding site [chemical binding]; other site 351745010127 Q-loop/lid; other site 351745010128 ABC transporter signature motif; other site 351745010129 Walker B; other site 351745010130 D-loop; other site 351745010131 H-loop/switch region; other site 351745010132 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 351745010133 active site 351745010134 aromatic acid decarboxylase; Validated; Region: PRK05920 351745010135 Flavoprotein; Region: Flavoprotein; pfam02441 351745010136 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 351745010137 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 351745010138 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 351745010139 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 351745010140 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 351745010141 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 351745010142 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 351745010143 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 351745010144 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 351745010145 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 351745010146 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 351745010147 substrate binding site [chemical binding]; other site 351745010148 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 351745010149 muropeptide transporter; Reviewed; Region: ampG; PRK11902 351745010150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745010151 putative substrate translocation pore; other site 351745010152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 351745010153 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 351745010154 Predicted integral membrane protein [Function unknown]; Region: COG5652 351745010155 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 351745010156 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 351745010157 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 351745010158 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 351745010159 Nitrogen regulatory protein P-II; Region: P-II; smart00938 351745010160 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 351745010161 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745010162 Protein of unknown function (DUF819); Region: DUF819; cl02317 351745010163 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 351745010164 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745010165 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 351745010166 dimerization interface [polypeptide binding]; other site 351745010167 Gram-negative porin; Region: Porin_4; pfam13609 351745010168 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 351745010169 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 351745010170 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 351745010171 Protein of unknown function (DUF819); Region: DUF819; cl02317 351745010172 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 351745010173 Tetratricopeptide repeat; Region: TPR_9; pfam13371 351745010174 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 351745010175 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 351745010176 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 351745010177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745010178 peptide chain release factor 1; Validated; Region: prfA; PRK00591 351745010179 This domain is found in peptide chain release factors; Region: PCRF; smart00937 351745010180 RF-1 domain; Region: RF-1; pfam00472 351745010181 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 351745010182 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 351745010183 tRNA; other site 351745010184 putative tRNA binding site [nucleotide binding]; other site 351745010185 putative NADP binding site [chemical binding]; other site 351745010186 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 351745010187 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 351745010188 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 351745010189 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 351745010190 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 351745010191 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 351745010192 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 351745010193 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 351745010194 active site 351745010195 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 351745010196 dimerization interface [polypeptide binding]; other site 351745010197 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745010198 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745010199 dimer interface [polypeptide binding]; other site 351745010200 putative CheW interface [polypeptide binding]; other site 351745010201 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 351745010202 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 351745010203 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 351745010204 DNA binding residues [nucleotide binding] 351745010205 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 351745010206 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 351745010207 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 351745010208 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 351745010209 RNA binding surface [nucleotide binding]; other site 351745010210 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 351745010211 active site 351745010212 uracil binding [chemical binding]; other site 351745010213 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 351745010214 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 351745010215 active site 351745010216 Zn binding site [ion binding]; other site 351745010217 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 351745010218 synthetase active site [active] 351745010219 NTP binding site [chemical binding]; other site 351745010220 metal binding site [ion binding]; metal-binding site 351745010221 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 351745010222 Bacterial PH domain; Region: DUF304; pfam03703 351745010223 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 351745010224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 351745010225 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 351745010226 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 351745010227 malate dehydrogenase; Provisional; Region: PRK13529 351745010228 Malic enzyme, N-terminal domain; Region: malic; pfam00390 351745010229 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 351745010230 NAD(P) binding site [chemical binding]; other site 351745010231 Protein of unknown function (DUF3069); Region: DUF3069; pfam11269 351745010232 epoxyqueuosine reductase; Region: TIGR00276 351745010233 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 351745010234 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 351745010235 eyelet of channel; other site 351745010236 trimer interface [polypeptide binding]; other site 351745010237 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 351745010238 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 351745010239 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 351745010240 putative ATP binding site [chemical binding]; other site 351745010241 putative substrate interface [chemical binding]; other site 351745010242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745010243 ATP binding site [chemical binding]; other site 351745010244 Mg2+ binding site [ion binding]; other site 351745010245 G-X-G motif; other site 351745010246 Superinfection exclusion protein B; Region: SieB; pfam14163 351745010247 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 351745010248 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745010249 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745010250 dimer interface [polypeptide binding]; other site 351745010251 putative CheW interface [polypeptide binding]; other site 351745010252 Hemerythrin; Region: Hemerythrin; cd12107 351745010253 Fe binding site [ion binding]; other site 351745010254 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 351745010255 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 351745010256 CAP-like domain; other site 351745010257 active site 351745010258 primary dimer interface [polypeptide binding]; other site 351745010259 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 351745010260 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 351745010261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745010262 ATP binding site [chemical binding]; other site 351745010263 Mg2+ binding site [ion binding]; other site 351745010264 G-X-G motif; other site 351745010265 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 351745010266 anchoring element; other site 351745010267 dimer interface [polypeptide binding]; other site 351745010268 ATP binding site [chemical binding]; other site 351745010269 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 351745010270 active site 351745010271 metal binding site [ion binding]; metal-binding site 351745010272 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 351745010273 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 351745010274 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 351745010275 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 351745010276 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 351745010277 active site 351745010278 metal binding site [ion binding]; metal-binding site 351745010279 hexamer interface [polypeptide binding]; other site 351745010280 Protein of unknown function (DUF1249); Region: DUF1249; pfam06853 351745010281 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 351745010282 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 351745010283 dimer interface [polypeptide binding]; other site 351745010284 ADP-ribose binding site [chemical binding]; other site 351745010285 active site 351745010286 nudix motif; other site 351745010287 metal binding site [ion binding]; metal-binding site 351745010288 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 351745010289 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 351745010290 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 351745010291 Protein of unknown function (DUF461); Region: DUF461; pfam04314 351745010292 enoyl-CoA hydratase; Provisional; Region: PRK06688 351745010293 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 351745010294 substrate binding site [chemical binding]; other site 351745010295 oxyanion hole (OAH) forming residues; other site 351745010296 trimer interface [polypeptide binding]; other site 351745010297 PspC domain; Region: PspC; pfam04024 351745010298 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 351745010299 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 351745010300 FMN binding site [chemical binding]; other site 351745010301 active site 351745010302 catalytic residues [active] 351745010303 substrate binding site [chemical binding]; other site 351745010304 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 351745010305 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 351745010306 alanine racemase; Reviewed; Region: alr; PRK00053 351745010307 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 351745010308 active site 351745010309 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 351745010310 substrate binding site [chemical binding]; other site 351745010311 catalytic residues [active] 351745010312 dimer interface [polypeptide binding]; other site 351745010313 replicative DNA helicase; Provisional; Region: PRK08006 351745010314 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 351745010315 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 351745010316 Walker A motif; other site 351745010317 ATP binding site [chemical binding]; other site 351745010318 Walker B motif; other site 351745010319 DNA binding loops [nucleotide binding] 351745010320 Peptidase S46; Region: Peptidase_S46; pfam10459 351745010321 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 351745010322 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 351745010323 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 351745010324 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 351745010325 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 351745010326 primosomal replication protein N; Provisional; Region: PRK02801 351745010327 generic binding surface II; other site 351745010328 generic binding surface I; other site 351745010329 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 351745010330 Protein of unknown function, DUF481; Region: DUF481; pfam04338 351745010331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745010332 Major Facilitator Superfamily; Region: MFS_1; pfam07690 351745010333 putative substrate translocation pore; other site 351745010334 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 351745010335 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 351745010336 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 351745010337 exoribonuclease R; Provisional; Region: PRK11642 351745010338 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 351745010339 RNB domain; Region: RNB; pfam00773 351745010340 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 351745010341 RNA binding site [nucleotide binding]; other site 351745010342 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 351745010343 Sel1-like repeats; Region: SEL1; smart00671 351745010344 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 351745010345 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 351745010346 GDP-binding site [chemical binding]; other site 351745010347 ACT binding site; other site 351745010348 IMP binding site; other site 351745010349 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 351745010350 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 351745010351 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 351745010352 23S rRNA interface [nucleotide binding]; other site 351745010353 L3 interface [polypeptide binding]; other site 351745010354 Predicted ATPase [General function prediction only]; Region: COG1485 351745010355 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 351745010356 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 351745010357 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 351745010358 protein binding site [polypeptide binding]; other site 351745010359 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 351745010360 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 351745010361 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 351745010362 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 351745010363 protein binding site [polypeptide binding]; other site 351745010364 His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977 351745010365 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351745010366 FeS/SAM binding site; other site 351745010367 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 351745010368 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351745010369 FeS/SAM binding site; other site 351745010370 HSF-type DNA-binding; Region: HSF_DNA-bind; cl12113 351745010371 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 351745010372 His-Xaa-Ser system protein HsxD; Region: chp_LLNDYxLRE; TIGR03976 351745010373 Serine hydrolase; Region: Ser_hydrolase; pfam06821 351745010374 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 351745010375 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 351745010376 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 351745010377 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 351745010378 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 351745010379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351745010380 dimer interface [polypeptide binding]; other site 351745010381 conserved gate region; other site 351745010382 putative PBP binding loops; other site 351745010383 ABC-ATPase subunit interface; other site 351745010384 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 351745010385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351745010386 dimer interface [polypeptide binding]; other site 351745010387 conserved gate region; other site 351745010388 putative PBP binding loops; other site 351745010389 ABC-ATPase subunit interface; other site 351745010390 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 351745010391 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 351745010392 Walker A/P-loop; other site 351745010393 ATP binding site [chemical binding]; other site 351745010394 Q-loop/lid; other site 351745010395 ABC transporter signature motif; other site 351745010396 Walker B; other site 351745010397 D-loop; other site 351745010398 H-loop/switch region; other site 351745010399 TOBE-like domain; Region: TOBE_3; pfam12857 351745010400 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 351745010401 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 351745010402 homodimer interface [polypeptide binding]; other site 351745010403 substrate-cofactor binding pocket; other site 351745010404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745010405 catalytic residue [active] 351745010406 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 351745010407 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 351745010408 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 351745010409 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 351745010410 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 351745010411 hinge; other site 351745010412 active site 351745010413 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 351745010414 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 351745010415 anti sigma factor interaction site; other site 351745010416 regulatory phosphorylation site [posttranslational modification]; other site 351745010417 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 351745010418 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 351745010419 mce related protein; Region: MCE; pfam02470 351745010420 Permease; Region: Permease; cl00510 351745010421 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 351745010422 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 351745010423 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 351745010424 Walker A/P-loop; other site 351745010425 ATP binding site [chemical binding]; other site 351745010426 Q-loop/lid; other site 351745010427 ABC transporter signature motif; other site 351745010428 Walker B; other site 351745010429 D-loop; other site 351745010430 H-loop/switch region; other site 351745010431 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 351745010432 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 351745010433 putative active site [active] 351745010434 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 351745010435 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 351745010436 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351745010437 active site 351745010438 motif I; other site 351745010439 motif II; other site 351745010440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 351745010441 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 351745010442 OstA-like protein; Region: OstA; cl00844 351745010443 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 351745010444 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 351745010445 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 351745010446 Walker A/P-loop; other site 351745010447 ATP binding site [chemical binding]; other site 351745010448 Q-loop/lid; other site 351745010449 ABC transporter signature motif; other site 351745010450 Walker B; other site 351745010451 D-loop; other site 351745010452 H-loop/switch region; other site 351745010453 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 351745010454 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 351745010455 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 351745010456 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 351745010457 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 351745010458 30S subunit binding site; other site 351745010459 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 351745010460 active site 351745010461 phosphorylation site [posttranslational modification] 351745010462 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 351745010463 AAA domain; Region: AAA_18; pfam13238 351745010464 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 351745010465 dimerization domain swap beta strand [polypeptide binding]; other site 351745010466 regulatory protein interface [polypeptide binding]; other site 351745010467 active site 351745010468 regulatory phosphorylation site [posttranslational modification]; other site 351745010469 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 351745010470 MgtE intracellular N domain; Region: MgtE_N; smart00924 351745010471 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 351745010472 Divalent cation transporter; Region: MgtE; pfam01769 351745010473 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 351745010474 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 351745010475 putative outer membrane lipoprotein; Provisional; Region: PRK10510 351745010476 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 351745010477 ligand binding site [chemical binding]; other site 351745010478 Transposase; Region: HTH_Tnp_1; cl17663 351745010479 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 351745010480 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 351745010481 ATP binding site [chemical binding]; other site 351745010482 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 351745010483 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 351745010484 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 351745010485 ring oligomerisation interface [polypeptide binding]; other site 351745010486 ATP/Mg binding site [chemical binding]; other site 351745010487 stacking interactions; other site 351745010488 hinge regions; other site 351745010489 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 351745010490 oligomerisation interface [polypeptide binding]; other site 351745010491 mobile loop; other site 351745010492 roof hairpin; other site 351745010493 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 351745010494 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 351745010495 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745010496 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745010497 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 351745010498 putative effector binding pocket; other site 351745010499 dimerization interface [polypeptide binding]; other site 351745010500 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 351745010501 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745010502 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 351745010503 SnoaL-like domain; Region: SnoaL_2; pfam12680 351745010504 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 351745010505 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 351745010506 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 351745010507 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 351745010508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 351745010509 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 351745010510 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 351745010511 Predicted transcriptional regulators [Transcription]; Region: COG1695 351745010512 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 351745010513 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 351745010514 catalytic residues [active] 351745010515 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 351745010516 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 351745010517 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 351745010518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745010519 Q-loop/lid; other site 351745010520 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745010521 ABC transporter signature motif; other site 351745010522 ABC transporter signature motif; other site 351745010523 Walker B; other site 351745010524 Walker B; other site 351745010525 D-loop; other site 351745010526 D-loop; other site 351745010527 H-loop/switch region; other site 351745010528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745010529 Walker A/P-loop; other site 351745010530 ATP binding site [chemical binding]; other site 351745010531 Q-loop/lid; other site 351745010532 ABC transporter signature motif; other site 351745010533 Walker B; other site 351745010534 D-loop; other site 351745010535 H-loop/switch region; other site 351745010536 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 351745010537 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 351745010538 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 351745010539 HAMP domain; Region: HAMP; pfam00672 351745010540 Histidine kinase; Region: HisKA_3; pfam07730 351745010541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745010542 ATP binding site [chemical binding]; other site 351745010543 Mg2+ binding site [ion binding]; other site 351745010544 G-X-G motif; other site 351745010545 transcriptional regulator NarL; Provisional; Region: PRK10651 351745010546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745010547 active site 351745010548 phosphorylation site [posttranslational modification] 351745010549 intermolecular recognition site; other site 351745010550 dimerization interface [polypeptide binding]; other site 351745010551 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 351745010552 DNA binding residues [nucleotide binding] 351745010553 dimerization interface [polypeptide binding]; other site 351745010554 Uncharacterized protein family (UPF0231); Region: UPF0231; pfam06062 351745010555 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 351745010556 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 351745010557 Cl binding site [ion binding]; other site 351745010558 oligomer interface [polypeptide binding]; other site 351745010559 aspartate kinase III; Validated; Region: PRK09084 351745010560 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 351745010561 nucleotide binding site [chemical binding]; other site 351745010562 substrate binding site [chemical binding]; other site 351745010563 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 351745010564 dimer interface [polypeptide binding]; other site 351745010565 allosteric regulatory binding pocket; other site 351745010566 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 351745010567 dimer interface [polypeptide binding]; other site 351745010568 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 351745010569 two-component response regulator; Provisional; Region: PRK11173 351745010570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745010571 active site 351745010572 phosphorylation site [posttranslational modification] 351745010573 intermolecular recognition site; other site 351745010574 dimerization interface [polypeptide binding]; other site 351745010575 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745010576 DNA binding site [nucleotide binding] 351745010577 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 351745010578 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 351745010579 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 351745010580 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 351745010581 AMP binding site [chemical binding]; other site 351745010582 metal binding site [ion binding]; metal-binding site 351745010583 active site 351745010584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 351745010585 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 351745010586 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 351745010587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 351745010588 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 351745010589 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 351745010590 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 351745010591 hypothetical protein; Provisional; Region: PRK01184 351745010592 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 351745010593 catalytic motif [active] 351745010594 Zn binding site [ion binding]; other site 351745010595 BON domain; Region: BON; pfam04972 351745010596 hypothetical protein; Provisional; Region: PRK05208 351745010597 Cache domain; Region: Cache_2; pfam08269 351745010598 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745010599 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745010600 dimer interface [polypeptide binding]; other site 351745010601 putative CheW interface [polypeptide binding]; other site 351745010602 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 351745010603 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 351745010604 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 351745010605 active site 351745010606 metal binding site [ion binding]; metal-binding site 351745010607 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 351745010608 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 351745010609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745010610 active site 351745010611 phosphorylation site [posttranslational modification] 351745010612 intermolecular recognition site; other site 351745010613 dimerization interface [polypeptide binding]; other site 351745010614 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 351745010615 DNA binding residues [nucleotide binding] 351745010616 dimerization interface [polypeptide binding]; other site 351745010617 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 351745010618 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 351745010619 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 351745010620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745010621 dimer interface [polypeptide binding]; other site 351745010622 phosphorylation site [posttranslational modification] 351745010623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745010624 ATP binding site [chemical binding]; other site 351745010625 Mg2+ binding site [ion binding]; other site 351745010626 G-X-G motif; other site 351745010627 tetrathionate reductase subunit B; Provisional; Region: PRK14993 351745010628 4Fe-4S binding domain; Region: Fer4; pfam00037 351745010629 tetrathionate reductase subunit C; Provisional; Region: PRK14992 351745010630 tetrathionate reductase subunit A; Provisional; Region: PRK14991 351745010631 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 351745010632 molybdopterin cofactor binding site; other site 351745010633 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 351745010634 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 351745010635 putative molybdopterin cofactor binding site; other site 351745010636 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745010637 PAS domain; Region: PAS_9; pfam13426 351745010638 putative active site [active] 351745010639 heme pocket [chemical binding]; other site 351745010640 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745010641 PAS domain; Region: PAS_9; pfam13426 351745010642 putative active site [active] 351745010643 heme pocket [chemical binding]; other site 351745010644 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745010645 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745010646 dimer interface [polypeptide binding]; other site 351745010647 putative CheW interface [polypeptide binding]; other site 351745010648 Protein of unknown function (DUF3581); Region: DUF3581; pfam12119 351745010649 Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935 351745010650 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 351745010651 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 351745010652 Transglycosylase; Region: Transgly; pfam00912 351745010653 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 351745010654 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 351745010655 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351745010656 ATP binding site [chemical binding]; other site 351745010657 putative Mg++ binding site [ion binding]; other site 351745010658 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745010659 nucleotide binding region [chemical binding]; other site 351745010660 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 351745010661 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 351745010662 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745010663 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745010664 metal binding site [ion binding]; metal-binding site 351745010665 active site 351745010666 I-site; other site 351745010667 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745010668 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 351745010669 Sel1-like repeats; Region: SEL1; smart00671 351745010670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 351745010671 binding surface 351745010672 TPR motif; other site 351745010673 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 351745010674 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 351745010675 ligand binding site [chemical binding]; other site 351745010676 flexible hinge region; other site 351745010677 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 351745010678 putative switch regulator; other site 351745010679 non-specific DNA interactions [nucleotide binding]; other site 351745010680 DNA binding site [nucleotide binding] 351745010681 sequence specific DNA binding site [nucleotide binding]; other site 351745010682 putative cAMP binding site [chemical binding]; other site 351745010683 Predicted membrane protein [Function unknown]; Region: COG3212 351745010684 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 351745010685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745010686 active site 351745010687 phosphorylation site [posttranslational modification] 351745010688 intermolecular recognition site; other site 351745010689 dimerization interface [polypeptide binding]; other site 351745010690 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745010691 DNA binding site [nucleotide binding] 351745010692 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 351745010693 HAMP domain; Region: HAMP; pfam00672 351745010694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 351745010695 dimer interface [polypeptide binding]; other site 351745010696 phosphorylation site [posttranslational modification] 351745010697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745010698 ATP binding site [chemical binding]; other site 351745010699 Mg2+ binding site [ion binding]; other site 351745010700 G-X-G motif; other site 351745010701 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 351745010702 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 351745010703 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 351745010704 NAD(P) binding site [chemical binding]; other site 351745010705 catalytic residues [active] 351745010706 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 351745010707 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 351745010708 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 351745010709 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 351745010710 inhibitor-cofactor binding pocket; inhibition site 351745010711 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745010712 catalytic residue [active] 351745010713 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 351745010714 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 351745010715 HDOD domain; Region: HDOD; pfam08668 351745010716 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 351745010717 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 351745010718 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 351745010719 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 351745010720 glutamine binding [chemical binding]; other site 351745010721 catalytic triad [active] 351745010722 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 351745010723 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 351745010724 dimer interface [polypeptide binding]; other site 351745010725 ssDNA binding site [nucleotide binding]; other site 351745010726 tetramer (dimer of dimers) interface [polypeptide binding]; other site 351745010727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745010728 Major Facilitator Superfamily; Region: MFS_1; pfam07690 351745010729 putative substrate translocation pore; other site 351745010730 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 351745010731 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 351745010732 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 351745010733 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 351745010734 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 351745010735 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 351745010736 ATP binding site [chemical binding]; other site 351745010737 Mg++ binding site [ion binding]; other site 351745010738 motif III; other site 351745010739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351745010740 nucleotide binding region [chemical binding]; other site 351745010741 ATP-binding site [chemical binding]; other site 351745010742 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 351745010743 putative RNA binding site [nucleotide binding]; other site 351745010744 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 351745010745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351745010746 active site 351745010747 motif I; other site 351745010748 motif II; other site 351745010749 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 351745010750 EamA-like transporter family; Region: EamA; pfam00892 351745010751 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 351745010752 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 351745010753 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 351745010754 Cytochrome c [Energy production and conversion]; Region: COG3258 351745010755 Cytochrome c; Region: Cytochrom_C; pfam00034 351745010756 Cytochrome c; Region: Cytochrom_C; cl11414 351745010757 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 351745010758 Cytochrome c; Region: Cytochrom_C; cl11414 351745010759 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 351745010760 Ethanolamine utilisation protein, EutH; Region: EutH; cl01248 351745010761 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 351745010762 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 351745010763 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745010764 transcriptional regulator SlyA; Provisional; Region: PRK03573 351745010765 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 351745010766 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745010767 dimerization interface [polypeptide binding]; other site 351745010768 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745010769 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745010770 dimer interface [polypeptide binding]; other site 351745010771 putative CheW interface [polypeptide binding]; other site 351745010772 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 351745010773 FAD binding site [chemical binding]; other site 351745010774 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 351745010775 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 351745010776 nucleotide binding site [chemical binding]; other site 351745010777 substrate binding site [chemical binding]; other site 351745010778 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 351745010779 O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080 351745010780 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 351745010781 homodimer interface [polypeptide binding]; other site 351745010782 substrate-cofactor binding pocket; other site 351745010783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745010784 catalytic residue [active] 351745010785 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 351745010786 dimerization interface [polypeptide binding]; other site 351745010787 DNA binding site [nucleotide binding] 351745010788 corepressor binding sites; other site 351745010789 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 351745010790 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 351745010791 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 351745010792 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 351745010793 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 351745010794 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 351745010795 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 351745010796 ATP binding site [chemical binding]; other site 351745010797 active site 351745010798 substrate binding site [chemical binding]; other site 351745010799 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 351745010800 EAL domain; Region: EAL; pfam00563 351745010801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 351745010802 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 351745010803 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 351745010804 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 351745010805 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745010806 N-terminal plug; other site 351745010807 ligand-binding site [chemical binding]; other site 351745010808 Methyltransferase domain; Region: Methyltransf_23; pfam13489 351745010809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745010810 S-adenosylmethionine binding site [chemical binding]; other site 351745010811 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745010812 Uncharacterized conserved protein [Function unknown]; Region: COG2968 351745010813 oxidative stress defense protein; Provisional; Region: PRK11087 351745010814 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 351745010815 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 351745010816 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351745010817 FeS/SAM binding site; other site 351745010818 fumarate hydratase; Reviewed; Region: fumC; PRK00485 351745010819 Class II fumarases; Region: Fumarase_classII; cd01362 351745010820 active site 351745010821 tetramer interface [polypeptide binding]; other site 351745010822 Domain of unknown function; Region: DUF331; pfam03889 351745010823 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 351745010824 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 351745010825 substrate binding pocket [chemical binding]; other site 351745010826 membrane-bound complex binding site; other site 351745010827 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 351745010828 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 351745010829 peptidase PmbA; Provisional; Region: PRK11040 351745010830 hypothetical protein; Provisional; Region: PRK05255 351745010831 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 351745010832 MgtC family; Region: MgtC; pfam02308 351745010833 hydroperoxidase II; Provisional; Region: katE; PRK11249 351745010834 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 351745010835 tetramer interface [polypeptide binding]; other site 351745010836 heme binding pocket [chemical binding]; other site 351745010837 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 351745010838 domain interactions; other site 351745010839 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 351745010840 Ion transport protein; Region: Ion_trans; pfam00520 351745010841 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 351745010842 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 351745010843 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 351745010844 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 351745010845 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 351745010846 ABC-2 type transporter; Region: ABC2_membrane; cl17235 351745010847 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 351745010848 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 351745010849 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745010850 Outer membrane efflux protein; Region: OEP; pfam02321 351745010851 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 351745010852 protease TldD; Provisional; Region: tldD; PRK10735 351745010853 nitrilase; Region: PLN02798 351745010854 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 351745010855 putative active site [active] 351745010856 catalytic triad [active] 351745010857 dimer interface [polypeptide binding]; other site 351745010858 TIGR02099 family protein; Region: TIGR02099 351745010859 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 351745010860 ribonuclease G; Provisional; Region: PRK11712 351745010861 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 351745010862 homodimer interface [polypeptide binding]; other site 351745010863 oligonucleotide binding site [chemical binding]; other site 351745010864 Maf-like protein; Region: Maf; pfam02545 351745010865 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 351745010866 active site 351745010867 dimer interface [polypeptide binding]; other site 351745010868 rod shape-determining protein MreD; Region: MreD; cl01087 351745010869 rod shape-determining protein MreC; Region: mreC; TIGR00219 351745010870 rod shape-determining protein MreC; Region: MreC; pfam04085 351745010871 rod shape-determining protein MreB; Provisional; Region: PRK13927 351745010872 MreB and similar proteins; Region: MreB_like; cd10225 351745010873 nucleotide binding site [chemical binding]; other site 351745010874 Mg binding site [ion binding]; other site 351745010875 putative protofilament interaction site [polypeptide binding]; other site 351745010876 RodZ interaction site [polypeptide binding]; other site 351745010877 legume lectins; Region: lectin_L-type; cl14058 351745010878 homotetramer interaction site [polypeptide binding]; other site 351745010879 homodimer interaction site [polypeptide binding]; other site 351745010880 carbohydrate binding site [chemical binding]; other site 351745010881 metal binding site [ion binding]; metal-binding site 351745010882 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 351745010883 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 351745010884 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 351745010885 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 351745010886 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 351745010887 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 351745010888 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 351745010889 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 351745010890 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 351745010891 Walker A motif; other site 351745010892 ATP binding site [chemical binding]; other site 351745010893 Walker B motif; other site 351745010894 TPR repeat; Region: TPR_11; pfam13414 351745010895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 351745010896 TPR motif; other site 351745010897 binding surface 351745010898 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 351745010899 binding surface 351745010900 TPR motif; other site 351745010901 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 351745010902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745010903 Walker A motif; other site 351745010904 ATP binding site [chemical binding]; other site 351745010905 Walker B motif; other site 351745010906 arginine finger; other site 351745010907 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 351745010908 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 351745010909 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 351745010910 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 351745010911 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 351745010912 regulatory protein CsrD; Provisional; Region: PRK11059 351745010913 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745010914 metal binding site [ion binding]; metal-binding site 351745010915 active site 351745010916 I-site; other site 351745010917 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745010918 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 351745010919 Malic enzyme, N-terminal domain; Region: malic; pfam00390 351745010920 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 351745010921 putative NAD(P) binding site [chemical binding]; other site 351745010922 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 351745010923 FimV N-terminal domain; Region: FimV_core; TIGR03505 351745010924 primosome assembly protein PriA; Validated; Region: PRK05580 351745010925 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351745010926 ATP binding site [chemical binding]; other site 351745010927 putative Mg++ binding site [ion binding]; other site 351745010928 helicase superfamily c-terminal domain; Region: HELICc; smart00490 351745010929 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 351745010930 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 351745010931 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 351745010932 active site 351745010933 HIGH motif; other site 351745010934 KMSK motif region; other site 351745010935 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 351745010936 tRNA binding surface [nucleotide binding]; other site 351745010937 anticodon binding site; other site 351745010938 Sporulation related domain; Region: SPOR; pfam05036 351745010939 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 351745010940 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 351745010941 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 351745010942 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 351745010943 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 351745010944 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 351745010945 uridine phosphorylase; Provisional; Region: PRK11178 351745010946 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 351745010947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 351745010948 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 351745010949 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 351745010950 dimer interface [polypeptide binding]; other site 351745010951 active site 351745010952 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 351745010953 catalytic residues [active] 351745010954 substrate binding site [chemical binding]; other site 351745010955 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 351745010956 Mechanosensitive ion channel; Region: MS_channel; pfam00924 351745010957 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 351745010958 Sel1-like repeats; Region: SEL1; smart00671 351745010959 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 351745010960 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 351745010961 substrate binding pocket [chemical binding]; other site 351745010962 membrane-bound complex binding site; other site 351745010963 hinge residues; other site 351745010964 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 351745010965 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 351745010966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745010967 ATP binding site [chemical binding]; other site 351745010968 Mg2+ binding site [ion binding]; other site 351745010969 G-X-G motif; other site 351745010970 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 351745010971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745010972 active site 351745010973 phosphorylation site [posttranslational modification] 351745010974 intermolecular recognition site; other site 351745010975 dimerization interface [polypeptide binding]; other site 351745010976 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 351745010977 DNA binding residues [nucleotide binding] 351745010978 dimerization interface [polypeptide binding]; other site 351745010979 RibD C-terminal domain; Region: RibD_C; cl17279 351745010980 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 351745010981 active site 351745010982 HslU subunit interaction site [polypeptide binding]; other site 351745010983 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 351745010984 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745010985 Walker A motif; other site 351745010986 ATP binding site [chemical binding]; other site 351745010987 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 351745010988 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 351745010989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 351745010990 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 351745010991 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 351745010992 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 351745010993 C factor cell-cell signaling protein; Provisional; Region: PRK09009 351745010994 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 351745010995 NADP binding site [chemical binding]; other site 351745010996 homodimer interface [polypeptide binding]; other site 351745010997 active site 351745010998 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 351745010999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745011000 active site 351745011001 phosphorylation site [posttranslational modification] 351745011002 intermolecular recognition site; other site 351745011003 dimerization interface [polypeptide binding]; other site 351745011004 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 351745011005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745011006 ATP binding site [chemical binding]; other site 351745011007 Mg2+ binding site [ion binding]; other site 351745011008 G-X-G motif; other site 351745011009 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 351745011010 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 351745011011 probable active site [active] 351745011012 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 351745011013 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 351745011014 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745011015 N-terminal plug; other site 351745011016 ligand-binding site [chemical binding]; other site 351745011017 Domain of unknown function (DUF386); Region: DUF386; cl01047 351745011018 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 351745011019 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 351745011020 DHHA2 domain; Region: DHHA2; pfam02833 351745011021 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 351745011022 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 351745011023 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 351745011024 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 351745011025 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745011026 dimer interface [polypeptide binding]; other site 351745011027 putative CheW interface [polypeptide binding]; other site 351745011028 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 351745011029 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 351745011030 PAP2 superfamily; Region: PAP2; pfam01569 351745011031 active site 351745011032 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 351745011033 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 351745011034 putative active site [active] 351745011035 putative metal binding site [ion binding]; other site 351745011036 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 351745011037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745011038 S-adenosylmethionine binding site [chemical binding]; other site 351745011039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 351745011040 SCP-2 sterol transfer family; Region: SCP2; pfam02036 351745011041 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 351745011042 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 351745011043 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 351745011044 sec-independent translocase; Provisional; Region: PRK01770 351745011045 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 351745011046 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 351745011047 active site 351745011048 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 351745011049 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 351745011050 hypothetical protein; Region: PHA02277 351745011051 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745011052 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745011053 metal binding site [ion binding]; metal-binding site 351745011054 active site 351745011055 I-site; other site 351745011056 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 351745011057 dimer interface [polypeptide binding]; other site 351745011058 allosteric magnesium binding site [ion binding]; other site 351745011059 active site 351745011060 aspartate-rich active site metal binding site; other site 351745011061 Schiff base residues; other site 351745011062 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 351745011063 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 351745011064 glutamate racemase; Provisional; Region: PRK00865 351745011065 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 351745011066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745011067 S-adenosylmethionine binding site [chemical binding]; other site 351745011068 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 351745011069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 351745011070 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 351745011071 Fatty acid desaturase; Region: FA_desaturase; pfam00487 351745011072 Di-iron ligands [ion binding]; other site 351745011073 selenophosphate synthetase; Provisional; Region: PRK00943 351745011074 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 351745011075 dimerization interface [polypeptide binding]; other site 351745011076 putative ATP binding site [chemical binding]; other site 351745011077 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 351745011078 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 351745011079 active site residue [active] 351745011080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745011081 putative substrate translocation pore; other site 351745011082 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 351745011083 putative acyl-acceptor binding pocket; other site 351745011084 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 351745011085 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 351745011086 WHG domain; Region: WHG; pfam13305 351745011087 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 351745011088 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 351745011089 Coenzyme A binding pocket [chemical binding]; other site 351745011090 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 351745011091 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 351745011092 active site 351745011093 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 351745011094 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 351745011095 dimer interface [polypeptide binding]; other site 351745011096 ADP-ribose binding site [chemical binding]; other site 351745011097 active site 351745011098 nudix motif; other site 351745011099 metal binding site [ion binding]; metal-binding site 351745011100 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 351745011101 Interdomain contacts; other site 351745011102 Cytokine receptor motif; other site 351745011103 Cadherin repeat-like domain; Region: CA_like; cl15786 351745011104 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 351745011105 Ca2+ binding site [ion binding]; other site 351745011106 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 351745011107 Cadherin repeat-like domain; Region: CA_like; cl15786 351745011108 Ca2+ binding site [ion binding]; other site 351745011109 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 351745011110 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 351745011111 Phage Tail Collar Domain; Region: Collar; pfam07484 351745011112 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 351745011113 Coenzyme A binding pocket [chemical binding]; other site 351745011114 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 351745011115 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 351745011116 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 351745011117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351745011118 motif II; other site 351745011119 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 351745011120 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 351745011121 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 351745011122 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 351745011123 GspL periplasmic domain; Region: GspL_C; pfam12693 351745011124 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 351745011125 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 351745011126 type II secretion system protein J; Region: gspJ; TIGR01711 351745011127 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 351745011128 type II secretion system protein I; Region: gspI; TIGR01707 351745011129 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 351745011130 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 351745011131 Type II transport protein GspH; Region: GspH; pfam12019 351745011132 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 351745011133 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 351745011134 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 351745011135 type II secretion system protein F; Region: GspF; TIGR02120 351745011136 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 351745011137 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 351745011138 type II secretion system protein E; Region: type_II_gspE; TIGR02533 351745011139 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 351745011140 Walker A motif; other site 351745011141 ATP binding site [chemical binding]; other site 351745011142 Walker B motif; other site 351745011143 type II secretion system protein D; Region: type_II_gspD; TIGR02517 351745011144 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 351745011145 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 351745011146 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 351745011147 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 351745011148 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 351745011149 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 351745011150 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 351745011151 RNA binding surface [nucleotide binding]; other site 351745011152 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 351745011153 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 351745011154 dimerization interface [polypeptide binding]; other site 351745011155 domain crossover interface; other site 351745011156 redox-dependent activation switch; other site 351745011157 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 351745011158 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 351745011159 active site 351745011160 substrate-binding site [chemical binding]; other site 351745011161 metal-binding site [ion binding] 351745011162 ATP binding site [chemical binding]; other site 351745011163 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 351745011164 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 351745011165 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 351745011166 Hemerythrin-like domain; Region: Hr-like; cd12108 351745011167 Divergent AAA domain; Region: AAA_4; pfam04326 351745011168 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 351745011169 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 351745011170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351745011171 motif II; other site 351745011172 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 351745011173 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 351745011174 active site 351745011175 Int/Topo IB signature motif; other site 351745011176 Protein of unknown function, DUF484; Region: DUF484; cl17449 351745011177 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 351745011178 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 351745011179 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 351745011180 diaminopimelate decarboxylase; Region: lysA; TIGR01048 351745011181 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 351745011182 active site 351745011183 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 351745011184 substrate binding site [chemical binding]; other site 351745011185 catalytic residues [active] 351745011186 dimer interface [polypeptide binding]; other site 351745011187 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 351745011188 putative iron binding site [ion binding]; other site 351745011189 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 351745011190 adenylate cyclase; Provisional; Region: cyaA; PRK09450 351745011191 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 351745011192 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 351745011193 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 351745011194 domain interfaces; other site 351745011195 active site 351745011196 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 351745011197 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 351745011198 active site 351745011199 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 351745011200 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 351745011201 HemY protein N-terminus; Region: HemY_N; pfam07219 351745011202 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 351745011203 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 351745011204 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 351745011205 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 351745011206 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 351745011207 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745011208 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 351745011209 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 351745011210 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 351745011211 ligand binding site [chemical binding]; other site 351745011212 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 351745011213 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745011214 dimerization interface [polypeptide binding]; other site 351745011215 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745011216 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745011217 metal binding site [ion binding]; metal-binding site 351745011218 active site 351745011219 I-site; other site 351745011220 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745011221 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 351745011222 GAF domain; Region: GAF; pfam01590 351745011223 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 351745011224 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 351745011225 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745011226 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745011227 metal binding site [ion binding]; metal-binding site 351745011228 active site 351745011229 I-site; other site 351745011230 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745011231 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 351745011232 Part of AAA domain; Region: AAA_19; pfam13245 351745011233 Family description; Region: UvrD_C_2; pfam13538 351745011234 Membrane fusogenic activity; Region: BMFP; pfam04380 351745011235 NnrS protein; Region: NnrS; pfam05940 351745011236 Cytochrome c552; Region: Cytochrom_C552; pfam02335 351745011237 inner membrane protein; Provisional; Region: PRK11715 351745011238 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 351745011239 active site 351745011240 Tim44-like domain; Region: Tim44; pfam04280 351745011241 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 351745011242 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 351745011243 homodimer interface [polypeptide binding]; other site 351745011244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745011245 catalytic residue [active] 351745011246 threonine dehydratase; Reviewed; Region: PRK09224 351745011247 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 351745011248 tetramer interface [polypeptide binding]; other site 351745011249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745011250 catalytic residue [active] 351745011251 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 351745011252 putative Ile/Val binding site [chemical binding]; other site 351745011253 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 351745011254 putative Ile/Val binding site [chemical binding]; other site 351745011255 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 351745011256 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 351745011257 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 351745011258 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 351745011259 PYR/PP interface [polypeptide binding]; other site 351745011260 dimer interface [polypeptide binding]; other site 351745011261 TPP binding site [chemical binding]; other site 351745011262 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 351745011263 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 351745011264 TPP-binding site [chemical binding]; other site 351745011265 dimer interface [polypeptide binding]; other site 351745011266 ketol-acid reductoisomerase; Validated; Region: PRK05225 351745011267 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 351745011268 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 351745011269 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 351745011270 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745011271 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 351745011272 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 351745011273 putative dimerization interface [polypeptide binding]; other site 351745011274 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 351745011275 Domain of unknown function DUF21; Region: DUF21; pfam01595 351745011276 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 351745011277 Transporter associated domain; Region: CorC_HlyC; smart01091 351745011278 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 351745011279 ERCC4 domain; Region: ERCC4; smart00891 351745011280 dUMP phosphatase; Provisional; Region: PRK09449 351745011281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351745011282 motif II; other site 351745011283 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745011284 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745011285 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 351745011286 putative effector binding pocket; other site 351745011287 dimerization interface [polypeptide binding]; other site 351745011288 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 351745011289 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 351745011290 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 351745011291 non-specific DNA binding site [nucleotide binding]; other site 351745011292 salt bridge; other site 351745011293 sequence-specific DNA binding site [nucleotide binding]; other site 351745011294 Fic family protein [Function unknown]; Region: COG3177 351745011295 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 351745011296 Fic/DOC family; Region: Fic; pfam02661 351745011297 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 351745011298 Phosphotransferase enzyme family; Region: APH; pfam01636 351745011299 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 351745011300 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 351745011301 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 351745011302 active site 351745011303 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 351745011304 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 351745011305 catalytic site [active] 351745011306 G-X2-G-X-G-K; other site 351745011307 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 351745011308 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 351745011309 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 351745011310 Zn2+ binding site [ion binding]; other site 351745011311 Mg2+ binding site [ion binding]; other site 351745011312 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 351745011313 synthetase active site [active] 351745011314 NTP binding site [chemical binding]; other site 351745011315 metal binding site [ion binding]; metal-binding site 351745011316 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 351745011317 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 351745011318 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 351745011319 homotrimer interaction site [polypeptide binding]; other site 351745011320 putative active site [active] 351745011321 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 351745011322 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 351745011323 acyl-activating enzyme (AAE) consensus motif; other site 351745011324 putative AMP binding site [chemical binding]; other site 351745011325 putative active site [active] 351745011326 putative CoA binding site [chemical binding]; other site 351745011327 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 351745011328 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 351745011329 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 351745011330 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 351745011331 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745011332 N-terminal plug; other site 351745011333 ligand-binding site [chemical binding]; other site 351745011334 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 351745011335 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 351745011336 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 351745011337 E-class dimer interface [polypeptide binding]; other site 351745011338 P-class dimer interface [polypeptide binding]; other site 351745011339 active site 351745011340 Cu2+ binding site [ion binding]; other site 351745011341 Zn2+ binding site [ion binding]; other site 351745011342 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 351745011343 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 351745011344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351745011345 Walker A motif; other site 351745011346 ATP binding site [chemical binding]; other site 351745011347 Walker B motif; other site 351745011348 arginine finger; other site 351745011349 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 351745011350 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 351745011351 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 351745011352 putative acyl-acceptor binding pocket; other site 351745011353 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 351745011354 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 351745011355 putative acyl-acceptor binding pocket; other site 351745011356 Uncharacterized conserved protein [Function unknown]; Region: COG1683 351745011357 Transcriptional regulators [Transcription]; Region: GntR; COG1802 351745011358 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 351745011359 DNA-binding site [nucleotide binding]; DNA binding site 351745011360 FCD domain; Region: FCD; pfam07729 351745011361 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 351745011362 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 351745011363 tetramer interface [polypeptide binding]; other site 351745011364 active site 351745011365 Mg2+/Mn2+ binding site [ion binding]; other site 351745011366 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 351745011367 dimer interface [polypeptide binding]; other site 351745011368 Citrate synthase; Region: Citrate_synt; pfam00285 351745011369 active site 351745011370 citrylCoA binding site [chemical binding]; other site 351745011371 oxalacetate/citrate binding site [chemical binding]; other site 351745011372 coenzyme A binding site [chemical binding]; other site 351745011373 catalytic triad [active] 351745011374 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 351745011375 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 351745011376 substrate binding site [chemical binding]; other site 351745011377 ligand binding site [chemical binding]; other site 351745011378 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 351745011379 substrate binding site [chemical binding]; other site 351745011380 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 351745011381 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 351745011382 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 351745011383 tetramer interface [polypeptide binding]; other site 351745011384 active site 351745011385 Mg2+/Mn2+ binding site [ion binding]; other site 351745011386 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 351745011387 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 351745011388 PAS fold; Region: PAS_3; pfam08447 351745011389 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745011390 PAS domain; Region: PAS_9; pfam13426 351745011391 putative active site [active] 351745011392 heme pocket [chemical binding]; other site 351745011393 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745011394 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745011395 metal binding site [ion binding]; metal-binding site 351745011396 active site 351745011397 I-site; other site 351745011398 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745011399 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 351745011400 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 351745011401 homodimer interface [polypeptide binding]; other site 351745011402 substrate-cofactor binding pocket; other site 351745011403 catalytic residue [active] 351745011404 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; pfam07073 351745011405 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 351745011406 homotrimer interaction site [polypeptide binding]; other site 351745011407 putative active site [active] 351745011408 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 351745011409 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 351745011410 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 351745011411 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 351745011412 catalytic residues [active] 351745011413 hinge region; other site 351745011414 alpha helical domain; other site 351745011415 serine/threonine protein kinase; Provisional; Region: PRK11768 351745011416 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 351745011417 Protein of unknown function (DUF3630); Region: DUF3630; pfam12305 351745011418 Uncharacterized conserved protein [Function unknown]; Region: COG0397 351745011419 hypothetical protein; Validated; Region: PRK00029 351745011420 ribonuclease E; Reviewed; Region: rne; PRK10811 351745011421 DsrE/DsrF-like family; Region: DrsE; cl00672 351745011422 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 351745011423 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 351745011424 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 351745011425 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 351745011426 putative ligand binding residues [chemical binding]; other site 351745011427 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 351745011428 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 351745011429 Walker A/P-loop; other site 351745011430 ATP binding site [chemical binding]; other site 351745011431 Q-loop/lid; other site 351745011432 ABC transporter signature motif; other site 351745011433 Walker B; other site 351745011434 D-loop; other site 351745011435 H-loop/switch region; other site 351745011436 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 351745011437 ABC-ATPase subunit interface; other site 351745011438 dimer interface [polypeptide binding]; other site 351745011439 putative PBP binding regions; other site 351745011440 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 351745011441 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 351745011442 ABC-ATPase subunit interface; other site 351745011443 dimer interface [polypeptide binding]; other site 351745011444 putative PBP binding regions; other site 351745011445 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 351745011446 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745011447 N-terminal plug; other site 351745011448 ligand-binding site [chemical binding]; other site 351745011449 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 351745011450 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 351745011451 Walker A/P-loop; other site 351745011452 ATP binding site [chemical binding]; other site 351745011453 Q-loop/lid; other site 351745011454 ABC transporter signature motif; other site 351745011455 Walker B; other site 351745011456 D-loop; other site 351745011457 H-loop/switch region; other site 351745011458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745011459 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 351745011460 Walker A/P-loop; other site 351745011461 ATP binding site [chemical binding]; other site 351745011462 Q-loop/lid; other site 351745011463 ABC transporter signature motif; other site 351745011464 Walker B; other site 351745011465 D-loop; other site 351745011466 H-loop/switch region; other site 351745011467 Acyltransferase family; Region: Acyl_transf_3; pfam01757 351745011468 Uncharacterized conserved protein [Function unknown]; Region: COG3339 351745011469 Protein of unknown function (DUF2618); Region: DUF2618; pfam10940 351745011470 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 351745011471 Transposase [DNA replication, recombination, and repair]; Region: COG5421 351745011472 ornithine decarboxylase; Provisional; Region: PRK13578 351745011473 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 351745011474 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 351745011475 homodimer interface [polypeptide binding]; other site 351745011476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351745011477 catalytic residue [active] 351745011478 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 351745011479 putrescine transporter; Provisional; Region: potE; PRK10655 351745011480 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 351745011481 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 351745011482 trimer interface [polypeptide binding]; other site 351745011483 eyelet of channel; other site 351745011484 hypothetical protein; Provisional; Region: PRK01254 351745011485 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 351745011486 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 351745011487 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 351745011488 MAPEG family; Region: MAPEG; cl09190 351745011489 Uncharacterized conserved protein [Function unknown]; Region: COG2966 351745011490 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 351745011491 Uncharacterized conserved protein [Function unknown]; Region: COG3610 351745011492 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 351745011493 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 351745011494 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 351745011495 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 351745011496 conserved cys residue [active] 351745011497 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 351745011498 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 351745011499 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 351745011500 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 351745011501 putative SAM binding site [chemical binding]; other site 351745011502 putative homodimer interface [polypeptide binding]; other site 351745011503 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 351745011504 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 351745011505 putative ligand binding site [chemical binding]; other site 351745011506 hypothetical protein; Reviewed; Region: PRK12497 351745011507 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 351745011508 dimer interface [polypeptide binding]; other site 351745011509 active site 351745011510 BON domain; Region: BON; pfam04972 351745011511 BON domain; Region: BON; pfam04972 351745011512 EamA-like transporter family; Region: EamA; pfam00892 351745011513 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 351745011514 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 351745011515 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745011516 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 351745011517 dimerization interface [polypeptide binding]; other site 351745011518 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 351745011519 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 351745011520 active site 351745011521 HIGH motif; other site 351745011522 dimer interface [polypeptide binding]; other site 351745011523 KMSKS motif; other site 351745011524 phosphoglycolate phosphatase; Provisional; Region: PRK13222 351745011525 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351745011526 motif II; other site 351745011527 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 351745011528 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 351745011529 substrate binding site [chemical binding]; other site 351745011530 hexamer interface [polypeptide binding]; other site 351745011531 metal binding site [ion binding]; metal-binding site 351745011532 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 351745011533 AAA ATPase domain; Region: AAA_16; pfam13191 351745011534 AAA domain; Region: AAA_22; pfam13401 351745011535 Walker A motif; other site 351745011536 ATP binding site [chemical binding]; other site 351745011537 Walker B motif; other site 351745011538 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 351745011539 active site 351745011540 dimer interface [polypeptide binding]; other site 351745011541 metal binding site [ion binding]; metal-binding site 351745011542 shikimate kinase; Reviewed; Region: aroK; PRK00131 351745011543 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 351745011544 ADP binding site [chemical binding]; other site 351745011545 magnesium binding site [ion binding]; other site 351745011546 putative shikimate binding site; other site 351745011547 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 351745011548 Secretin and TonB N terminus short domain; Region: STN; smart00965 351745011549 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 351745011550 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 351745011551 Pilus assembly protein, PilP; Region: PilP; pfam04351 351745011552 Pilus assembly protein, PilO; Region: PilO; pfam04350 351745011553 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 351745011554 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 351745011555 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 351745011556 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 351745011557 Competence protein A; Region: Competence_A; pfam11104 351745011558 nucleotide binding site [chemical binding]; other site 351745011559 Cell division protein FtsA; Region: FtsA; pfam14450 351745011560 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 351745011561 Transglycosylase; Region: Transgly; pfam00912 351745011562 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 351745011563 argininosuccinate lyase; Provisional; Region: PRK04833 351745011564 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 351745011565 active sites [active] 351745011566 tetramer interface [polypeptide binding]; other site 351745011567 argininosuccinate synthase; Provisional; Region: PRK13820 351745011568 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 351745011569 ANP binding site [chemical binding]; other site 351745011570 Substrate Binding Site II [chemical binding]; other site 351745011571 Substrate Binding Site I [chemical binding]; other site 351745011572 ornithine carbamoyltransferase; Provisional; Region: PRK14805 351745011573 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 351745011574 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 351745011575 acetylglutamate kinase; Provisional; Region: PRK00942 351745011576 nucleotide binding site [chemical binding]; other site 351745011577 substrate binding site [chemical binding]; other site 351745011578 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 351745011579 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 351745011580 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 351745011581 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 351745011582 Protein of unknown function (DUF1439); Region: DUF1439; pfam07273 351745011583 competence damage-inducible protein A; Provisional; Region: PRK00549 351745011584 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 351745011585 putative MPT binding site; other site 351745011586 Competence-damaged protein; Region: CinA; pfam02464 351745011587 Helix-turn-helix domain; Region: HTH_17; pfam12728 351745011588 PBP superfamily domain; Region: PBP_like; pfam12727 351745011589 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 351745011590 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 351745011591 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 351745011592 Ferredoxin [Energy production and conversion]; Region: COG1146 351745011593 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 351745011594 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 351745011595 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 351745011596 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 351745011597 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 351745011598 [4Fe-4S] binding site [ion binding]; other site 351745011599 molybdopterin cofactor binding site; other site 351745011600 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 351745011601 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 351745011602 molybdopterin cofactor binding site; other site 351745011603 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 351745011604 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 351745011605 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 351745011606 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 351745011607 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 351745011608 [4Fe-4S] binding site [ion binding]; other site 351745011609 molybdopterin cofactor binding site; other site 351745011610 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 351745011611 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 351745011612 molybdopterin cofactor binding site; other site 351745011613 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 351745011614 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 351745011615 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 351745011616 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 351745011617 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745011618 N-terminal plug; other site 351745011619 ligand-binding site [chemical binding]; other site 351745011620 Methyltransferase domain; Region: Methyltransf_23; pfam13489 351745011621 Methyltransferase domain; Region: Methyltransf_11; pfam08241 351745011622 PAS domain S-box; Region: sensory_box; TIGR00229 351745011623 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745011624 putative active site [active] 351745011625 heme pocket [chemical binding]; other site 351745011626 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745011627 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745011628 metal binding site [ion binding]; metal-binding site 351745011629 active site 351745011630 I-site; other site 351745011631 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745011632 DTW domain; Region: DTW; cl01221 351745011633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745011634 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 351745011635 putative substrate translocation pore; other site 351745011636 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 351745011637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745011638 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 351745011639 substrate binding pocket [chemical binding]; other site 351745011640 dimerization interface [polypeptide binding]; other site 351745011641 Cache domain; Region: Cache_1; pfam02743 351745011642 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 351745011643 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 351745011644 dimerization interface [polypeptide binding]; other site 351745011645 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 351745011646 dimer interface [polypeptide binding]; other site 351745011647 putative CheW interface [polypeptide binding]; other site 351745011648 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 351745011649 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 351745011650 Sel1-like repeats; Region: SEL1; smart00671 351745011651 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 351745011652 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 351745011653 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 351745011654 putative metal binding site [ion binding]; other site 351745011655 Spore germination protein; Region: Spore_permease; cl17796 351745011656 putative transporter; Provisional; Region: PRK11021 351745011657 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 351745011658 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 351745011659 dimerization interface [polypeptide binding]; other site 351745011660 putative Zn2+ binding site [ion binding]; other site 351745011661 putative DNA binding site [nucleotide binding]; other site 351745011662 AsnC family; Region: AsnC_trans_reg; pfam01037 351745011663 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 351745011664 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 351745011665 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 351745011666 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 351745011667 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 351745011668 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351745011669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351745011670 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 351745011671 dimerization interface [polypeptide binding]; other site 351745011672 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 351745011673 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 351745011674 dimer interface [polypeptide binding]; other site 351745011675 tetramer interface [polypeptide binding]; other site 351745011676 PYR/PP interface [polypeptide binding]; other site 351745011677 TPP binding site [chemical binding]; other site 351745011678 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 351745011679 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 351745011680 TPP-binding site; other site 351745011681 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 351745011682 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 351745011683 nucleophilic elbow; other site 351745011684 catalytic triad; other site 351745011685 O-succinylbenzoate synthase; Provisional; Region: PRK05105 351745011686 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 351745011687 active site 351745011688 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 351745011689 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 351745011690 acyl-activating enzyme (AAE) consensus motif; other site 351745011691 putative AMP binding site [chemical binding]; other site 351745011692 putative active site [active] 351745011693 putative CoA binding site [chemical binding]; other site 351745011694 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 351745011695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745011696 active site 351745011697 phosphorylation site [posttranslational modification] 351745011698 intermolecular recognition site; other site 351745011699 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745011700 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 351745011701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745011702 active site 351745011703 phosphorylation site [posttranslational modification] 351745011704 intermolecular recognition site; other site 351745011705 dimerization interface [polypeptide binding]; other site 351745011706 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 351745011707 DNA binding residues [nucleotide binding] 351745011708 dimerization interface [polypeptide binding]; other site 351745011709 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 351745011710 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 351745011711 substrate binding pocket [chemical binding]; other site 351745011712 membrane-bound complex binding site; other site 351745011713 hinge residues; other site 351745011714 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 351745011715 substrate binding pocket [chemical binding]; other site 351745011716 membrane-bound complex binding site; other site 351745011717 hinge residues; other site 351745011718 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745011719 dimer interface [polypeptide binding]; other site 351745011720 phosphorylation site [posttranslational modification] 351745011721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745011722 ATP binding site [chemical binding]; other site 351745011723 Mg2+ binding site [ion binding]; other site 351745011724 G-X-G motif; other site 351745011725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745011726 active site 351745011727 phosphorylation site [posttranslational modification] 351745011728 intermolecular recognition site; other site 351745011729 dimerization interface [polypeptide binding]; other site 351745011730 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 351745011731 putative binding surface; other site 351745011732 active site 351745011733 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 351745011734 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 351745011735 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 351745011736 Fimbrial protein; Region: Fimbrial; cl01416 351745011737 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 351745011738 PapC N-terminal domain; Region: PapC_N; pfam13954 351745011739 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 351745011740 PapC C-terminal domain; Region: PapC_C; pfam13953 351745011741 putative chaperone protein EcpD; Provisional; Region: PRK09926 351745011742 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 351745011743 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 351745011744 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 351745011745 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 351745011746 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 351745011747 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 351745011748 DNA binding residues [nucleotide binding] 351745011749 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 351745011750 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 351745011751 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 351745011752 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745011753 Walker A/P-loop; other site 351745011754 ATP binding site [chemical binding]; other site 351745011755 Q-loop/lid; other site 351745011756 ABC transporter signature motif; other site 351745011757 Walker B; other site 351745011758 D-loop; other site 351745011759 H-loop/switch region; other site 351745011760 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 351745011761 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 351745011762 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 351745011763 P loop; other site 351745011764 GTP binding site [chemical binding]; other site 351745011765 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 351745011766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745011767 S-adenosylmethionine binding site [chemical binding]; other site 351745011768 Protein of unknown function (DUF1145); Region: DUF1145; cl11481 351745011769 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 351745011770 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 351745011771 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 351745011772 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745011773 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 351745011774 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 351745011775 active site 351745011776 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 351745011777 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 351745011778 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 351745011779 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 351745011780 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 351745011781 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 351745011782 putative active site [active] 351745011783 Zn binding site [ion binding]; other site 351745011784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745011785 S-adenosylmethionine binding site [chemical binding]; other site 351745011786 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 351745011787 Transposase [DNA replication, recombination, and repair]; Region: COG5421 351745011788 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 351745011789 Coenzyme A binding pocket [chemical binding]; other site 351745011790 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 351745011791 Transglycosylase; Region: Transgly; pfam00912 351745011792 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 351745011793 GIY-YIG motif/motif A; other site 351745011794 putative active site [active] 351745011795 putative metal binding site [ion binding]; other site 351745011796 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 351745011797 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 351745011798 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 351745011799 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 351745011800 Nitrate and nitrite sensing; Region: NIT; pfam08376 351745011801 HAMP domain; Region: HAMP; pfam00672 351745011802 dimerization interface [polypeptide binding]; other site 351745011803 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 351745011804 PAS domain; Region: PAS_9; pfam13426 351745011805 putative active site [active] 351745011806 heme pocket [chemical binding]; other site 351745011807 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 351745011808 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745011809 metal binding site [ion binding]; metal-binding site 351745011810 active site 351745011811 I-site; other site 351745011812 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745011813 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 351745011814 Ferritin-like domain; Region: Ferritin; pfam00210 351745011815 ferroxidase diiron center [ion binding]; other site 351745011816 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 351745011817 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 351745011818 dimer interface [polypeptide binding]; other site 351745011819 putative functional site; other site 351745011820 putative MPT binding site; other site 351745011821 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 351745011822 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 351745011823 ATP binding site [chemical binding]; other site 351745011824 substrate interface [chemical binding]; other site 351745011825 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 351745011826 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 351745011827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745011828 S-adenosylmethionine binding site [chemical binding]; other site 351745011829 flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697 351745011830 Chorismate lyase; Region: Chor_lyase; cl01230 351745011831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 351745011832 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 351745011833 putative antibiotic transporter; Provisional; Region: PRK10739 351745011834 Glycogen synthase [Carbohydrate transport and metabolism]; Region: GlgA; COG0297 351745011835 NRDE protein; Region: NRDE; cl01315 351745011836 SnoaL-like domain; Region: SnoaL_3; pfam13474 351745011837 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 351745011838 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 351745011839 putative acyl-acceptor binding pocket; other site 351745011840 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 351745011841 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 351745011842 Mechanosensitive ion channel; Region: MS_channel; pfam00924 351745011843 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 351745011844 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 351745011845 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 351745011846 catalytic residues [active] 351745011847 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 351745011848 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 351745011849 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 351745011850 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 351745011851 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 351745011852 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 351745011853 DsbD alpha interface [polypeptide binding]; other site 351745011854 catalytic residues [active] 351745011855 Protein of unknown function (DUF3157); Region: DUF3157; pfam11355 351745011856 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 351745011857 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 351745011858 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 351745011859 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 351745011860 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 351745011861 Peptidase family M48; Region: Peptidase_M48; cl12018 351745011862 Pilin (bacterial filament); Region: Pilin; pfam00114 351745011863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745011864 S-adenosylmethionine binding site [chemical binding]; other site 351745011865 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 351745011866 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 351745011867 metal binding site [ion binding]; metal-binding site 351745011868 active site 351745011869 I-site; other site 351745011870 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 351745011871 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 351745011872 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 351745011873 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 351745011874 N-acetyl-D-glucosamine binding site [chemical binding]; other site 351745011875 catalytic residue [active] 351745011876 LemA family; Region: LemA; cl00742 351745011877 AbgT putative transporter family; Region: ABG_transport; pfam03806 351745011878 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 351745011879 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 351745011880 Protein export membrane protein; Region: SecD_SecF; cl14618 351745011881 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 351745011882 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 351745011883 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745011884 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 351745011885 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 351745011886 C-terminal domain interface [polypeptide binding]; other site 351745011887 GSH binding site (G-site) [chemical binding]; other site 351745011888 dimer interface [polypeptide binding]; other site 351745011889 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 351745011890 N-terminal domain interface [polypeptide binding]; other site 351745011891 dimer interface [polypeptide binding]; other site 351745011892 substrate binding pocket (H-site) [chemical binding]; other site 351745011893 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 351745011894 active site 351745011895 oligopeptidase A; Provisional; Region: PRK10911 351745011896 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 351745011897 active site 351745011898 Zn binding site [ion binding]; other site 351745011899 glutathione reductase; Validated; Region: PRK06116 351745011900 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 351745011901 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 351745011902 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 351745011903 AAA domain; Region: AAA_14; pfam13173 351745011904 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 351745011905 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 351745011906 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 351745011907 active site 351745011908 catalytic residues [active] 351745011909 DNA binding site [nucleotide binding] 351745011910 Int/Topo IB signature motif; other site 351745011911 hypothetical protein; Provisional; Region: PRK06153 351745011912 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 351745011913 ATP binding site [chemical binding]; other site 351745011914 substrate interface [chemical binding]; other site 351745011915 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 351745011916 putative DNA binding site [nucleotide binding]; other site 351745011917 putative Zn2+ binding site [ion binding]; other site 351745011918 Transcription initiation factor IIE; Region: TFIIE; smart00531 351745011919 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 351745011920 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 351745011921 Na binding site [ion binding]; other site 351745011922 gamma-glutamyl kinase; Provisional; Region: PRK13402 351745011923 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 351745011924 nucleotide binding site [chemical binding]; other site 351745011925 homotetrameric interface [polypeptide binding]; other site 351745011926 putative phosphate binding site [ion binding]; other site 351745011927 putative allosteric binding site; other site 351745011928 PUA domain; Region: PUA; cl00607 351745011929 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 351745011930 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 351745011931 putative catalytic cysteine [active] 351745011932 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 351745011933 active sites [active] 351745011934 tetramer interface [polypeptide binding]; other site 351745011935 urocanate hydratase; Provisional; Region: PRK05414 351745011936 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 351745011937 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 351745011938 DNA-binding site [nucleotide binding]; DNA binding site 351745011939 UTRA domain; Region: UTRA; pfam07702 351745011940 imidazolonepropionase; Validated; Region: PRK09356 351745011941 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 351745011942 active site 351745011943 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 351745011944 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 351745011945 FAD binding pocket [chemical binding]; other site 351745011946 FAD binding motif [chemical binding]; other site 351745011947 phosphate binding motif [ion binding]; other site 351745011948 NAD binding pocket [chemical binding]; other site 351745011949 Transcriptional regulators [Transcription]; Region: MarR; COG1846 351745011950 MarR family; Region: MarR_2; pfam12802 351745011951 MarR family; Region: MarR_2; cl17246 351745011952 Putative phosphatase (DUF442); Region: DUF442; cl17385 351745011953 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 351745011954 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 351745011955 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 351745011956 putative active site [active] 351745011957 catalytic site [active] 351745011958 putative metal binding site [ion binding]; other site 351745011959 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 351745011960 Uncharacterized conserved protein [Function unknown]; Region: COG3791 351745011961 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 351745011962 active site 351745011963 Predicted acetyltransferase [General function prediction only]; Region: COG2388 351745011964 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 351745011965 active site 351745011966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 351745011967 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 351745011968 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 351745011969 acyl-activating enzyme (AAE) consensus motif; other site 351745011970 putative AMP binding site [chemical binding]; other site 351745011971 putative active site [active] 351745011972 putative CoA binding site [chemical binding]; other site 351745011973 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 351745011974 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 351745011975 Walker A/P-loop; other site 351745011976 ATP binding site [chemical binding]; other site 351745011977 Q-loop/lid; other site 351745011978 ABC transporter signature motif; other site 351745011979 Walker B; other site 351745011980 D-loop; other site 351745011981 H-loop/switch region; other site 351745011982 Predicted transcriptional regulators [Transcription]; Region: COG1725 351745011983 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 351745011984 DNA-binding site [nucleotide binding]; DNA binding site 351745011985 TAP-like protein; Region: Abhydrolase_4; pfam08386 351745011986 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 351745011987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351745011988 Walker A/P-loop; other site 351745011989 ATP binding site [chemical binding]; other site 351745011990 Q-loop/lid; other site 351745011991 ABC transporter signature motif; other site 351745011992 Walker B; other site 351745011993 D-loop; other site 351745011994 H-loop/switch region; other site 351745011995 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 351745011996 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 351745011997 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 351745011998 MPT binding site; other site 351745011999 trimer interface [polypeptide binding]; other site 351745012000 NlpC/P60 family; Region: NLPC_P60; pfam00877 351745012001 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 351745012002 Pirin-related protein [General function prediction only]; Region: COG1741 351745012003 Pirin; Region: Pirin; pfam02678 351745012004 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 351745012005 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 351745012006 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745012007 dimer interface [polypeptide binding]; other site 351745012008 phosphorylation site [posttranslational modification] 351745012009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745012010 ATP binding site [chemical binding]; other site 351745012011 Mg2+ binding site [ion binding]; other site 351745012012 G-X-G motif; other site 351745012013 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 351745012014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745012015 active site 351745012016 phosphorylation site [posttranslational modification] 351745012017 intermolecular recognition site; other site 351745012018 dimerization interface [polypeptide binding]; other site 351745012019 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745012020 DNA binding site [nucleotide binding] 351745012021 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 351745012022 TrkA-N domain; Region: TrkA_N; pfam02254 351745012023 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 351745012024 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 351745012025 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 351745012026 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 351745012027 HI0933-like protein; Region: HI0933_like; pfam03486 351745012028 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 351745012029 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 351745012030 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 351745012031 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 351745012032 SecA binding site; other site 351745012033 Preprotein binding site; other site 351745012034 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 351745012035 active site residue [active] 351745012036 phosphoglyceromutase; Provisional; Region: PRK05434 351745012037 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 351745012038 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 351745012039 Peptidase family M23; Region: Peptidase_M23; pfam01551 351745012040 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 351745012041 C-terminal peptidase (prc); Region: prc; TIGR00225 351745012042 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 351745012043 protein binding site [polypeptide binding]; other site 351745012044 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 351745012045 Catalytic dyad [active] 351745012046 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 351745012047 NodB motif; other site 351745012048 putative active site [active] 351745012049 putative catalytic site [active] 351745012050 Zn binding site [ion binding]; other site 351745012051 Transcriptional regulator; Region: Rrf2; cl17282 351745012052 Rrf2 family protein; Region: rrf2_super; TIGR00738 351745012053 Flagellin N-methylase; Region: FliB; cl00497 351745012054 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 351745012055 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 351745012056 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 351745012057 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 351745012058 substrate binding site [chemical binding]; other site 351745012059 oxyanion hole (OAH) forming residues; other site 351745012060 trimer interface [polypeptide binding]; other site 351745012061 Predicted membrane protein (DUF2061); Region: DUF2061; cl01257 351745012062 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 351745012063 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 351745012064 glutaminase active site [active] 351745012065 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 351745012066 dimer interface [polypeptide binding]; other site 351745012067 active site 351745012068 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 351745012069 dimer interface [polypeptide binding]; other site 351745012070 active site 351745012071 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 351745012072 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 351745012073 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 351745012074 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 351745012075 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 351745012076 N-terminal plug; other site 351745012077 ligand-binding site [chemical binding]; other site 351745012078 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 351745012079 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 351745012080 Substrate binding site; other site 351745012081 Mg++ binding site; other site 351745012082 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 351745012083 active site 351745012084 substrate binding site [chemical binding]; other site 351745012085 CoA binding site [chemical binding]; other site 351745012086 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 351745012087 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 351745012088 gamma subunit interface [polypeptide binding]; other site 351745012089 epsilon subunit interface [polypeptide binding]; other site 351745012090 LBP interface [polypeptide binding]; other site 351745012091 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 351745012092 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 351745012093 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 351745012094 alpha subunit interaction interface [polypeptide binding]; other site 351745012095 Walker A motif; other site 351745012096 ATP binding site [chemical binding]; other site 351745012097 Walker B motif; other site 351745012098 inhibitor binding site; inhibition site 351745012099 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 351745012100 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 351745012101 core domain interface [polypeptide binding]; other site 351745012102 delta subunit interface [polypeptide binding]; other site 351745012103 epsilon subunit interface [polypeptide binding]; other site 351745012104 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 351745012105 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 351745012106 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 351745012107 beta subunit interaction interface [polypeptide binding]; other site 351745012108 Walker A motif; other site 351745012109 ATP binding site [chemical binding]; other site 351745012110 Walker B motif; other site 351745012111 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 351745012112 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 351745012113 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 351745012114 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 351745012115 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 351745012116 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 351745012117 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 351745012118 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 351745012119 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 351745012120 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 351745012121 ParB-like nuclease domain; Region: ParBc; pfam02195 351745012122 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 351745012123 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 351745012124 P-loop; other site 351745012125 Magnesium ion binding site [ion binding]; other site 351745012126 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 351745012127 Magnesium ion binding site [ion binding]; other site 351745012128 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 351745012129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351745012130 S-adenosylmethionine binding site [chemical binding]; other site 351745012131 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 351745012132 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 351745012133 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 351745012134 FMN-binding protein MioC; Provisional; Region: PRK09004 351745012135 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 351745012136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351745012137 POT family; Region: PTR2; cl17359 351745012138 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 351745012139 Protein export membrane protein; Region: SecD_SecF; cl14618 351745012140 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 351745012141 HlyD family secretion protein; Region: HlyD_3; pfam13437 351745012142 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 351745012143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351745012144 active site 351745012145 phosphorylation site [posttranslational modification] 351745012146 intermolecular recognition site; other site 351745012147 dimerization interface [polypeptide binding]; other site 351745012148 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351745012149 DNA binding site [nucleotide binding] 351745012150 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 351745012151 HAMP domain; Region: HAMP; pfam00672 351745012152 dimerization interface [polypeptide binding]; other site 351745012153 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351745012154 dimer interface [polypeptide binding]; other site 351745012155 phosphorylation site [posttranslational modification] 351745012156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351745012157 ATP binding site [chemical binding]; other site 351745012158 Mg2+ binding site [ion binding]; other site 351745012159 G-X-G motif; other site 351745012160 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 351745012161 multiple promoter invertase; Provisional; Region: mpi; PRK13413 351745012162 catalytic residues [active] 351745012163 catalytic nucleophile [active] 351745012164 Presynaptic Site I dimer interface [polypeptide binding]; other site 351745012165 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 351745012166 Synaptic Flat tetramer interface [polypeptide binding]; other site 351745012167 Synaptic Site I dimer interface [polypeptide binding]; other site 351745012168 DNA binding site [nucleotide binding] 351745012169 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 351745012170 DNA-binding interface [nucleotide binding]; DNA binding site 351745012171 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 351745012172 Methyltransferase domain; Region: Methyltransf_26; pfam13659 351745012173 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 351745012174 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 351745012175 Integrase; Region: Integrase_1; pfam12835 351745012176 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 351745012177 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 351745012178 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 351745012179 conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14876 351745012180 Helix-turn-helix domain; Region: HTH_17; pfam12728 351745012181 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 351745012182 putative metalloprotease; Provisional; Region: PHA03081 351745012183 Helix-turn-helix domain; Region: HTH_17; pfam12728 351745012184 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 351745012185 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 351745012186 Int/Topo IB signature motif; other site 351745012187 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 351745012188 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 351745012189 trmE is a tRNA modification GTPase; Region: trmE; cd04164 351745012190 G1 box; other site 351745012191 GTP/Mg2+ binding site [chemical binding]; other site 351745012192 Switch I region; other site 351745012193 G2 box; other site 351745012194 Switch II region; other site 351745012195 G3 box; other site 351745012196 G4 box; other site 351745012197 G5 box; other site 351745012198 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 351745012199 membrane protein insertase; Provisional; Region: PRK01318 351745012200 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 351745012201 Haemolytic domain; Region: Haemolytic; pfam01809 351745012202 ribonuclease P; Reviewed; Region: rnpA; PRK01732 351745012203 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399