-- dump date 20140620_063244 -- class Genbank::misc_feature -- table misc_feature_note -- id note 693970000001 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 693970000002 Part of AAA domain; Region: AAA_19; pfam13245 693970000003 Type-1V conjugative transfer system mating pair stabilisation; Region: TraN; pfam06986 693970000004 TraU protein; Region: TraU; pfam06834 693970000005 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 693970000006 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 693970000007 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 693970000008 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 693970000009 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693970000010 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693970000011 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 693970000012 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 693970000013 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 693970000014 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693970000015 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 693970000016 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 693970000017 active site 693970000018 Zn binding site [ion binding]; other site 693970000019 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 693970000020 ParB-like nuclease domain; Region: ParB; smart00470 693970000021 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693970000022 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693970000023 P-loop; other site 693970000024 Magnesium ion binding site [ion binding]; other site 693970000025 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693970000026 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 693970000027 Initiator Replication protein; Region: Rep_3; pfam01051 693970000028 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 693970000029 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693970000030 dimer interface [polypeptide binding]; other site 693970000031 ssDNA binding site [nucleotide binding]; other site 693970000032 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693970000033 Peptidase M35 family; Region: M35_like; cl03449 693970000034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970000035 salt bridge; other site 693970000036 non-specific DNA binding site [nucleotide binding]; other site 693970000037 sequence-specific DNA binding site [nucleotide binding]; other site 693970000038 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 693970000039 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 693970000040 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 693970000041 TraE protein; Region: TraE; cl05060 693970000042 Domain of unknown function (DUF4400); Region: DUF4400; pfam14348 693970000043 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 693970000044 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 693970000045 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 693970000046 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 693970000047 PRTRC system protein D; Region: PRTRC_D; TIGR03739 693970000048 Mg binding site [ion binding]; other site 693970000049 nucleotide binding site [chemical binding]; other site 693970000050 putative protofilament interface [polypeptide binding]; other site 693970000051 F plasmid transfer operon protein; Region: TraF; pfam13728 693970000052 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 693970000053 catalytic residues [active] 693970000054 Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580 693970000055 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 693970000056 DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502 693970000057 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 693970000058 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693970000059 ligand binding site [chemical binding]; other site 693970000060 Domain of unknown function (DUF4165); Region: DUF4165; pfam13752 693970000061 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 693970000062 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 693970000063 Domain of unknown function (DUF4165); Region: DUF4165; pfam13752 693970000064 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 693970000065 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 693970000066 stationary phase growth adaptation protein; Provisional; Region: PRK09717 693970000067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970000068 S-adenosylmethionine binding site [chemical binding]; other site 693970000069 Methyltransferase domain; Region: Methyltransf_27; pfam13708 693970000070 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693970000071 active site 693970000072 DNA binding site [nucleotide binding] 693970000073 Int/Topo IB signature motif; other site 693970000074 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970000075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970000076 Walker A motif; other site 693970000077 ATP binding site [chemical binding]; other site 693970000078 Walker B motif; other site 693970000079 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 693970000080 ATP binding site [chemical binding]; other site 693970000081 Mg2+ binding site [ion binding]; other site 693970000082 G-X-G motif; other site 693970000083 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 693970000084 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 693970000085 H-NS histone family; Region: Histone_HNS; pfam00816 693970000086 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 693970000087 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 693970000088 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 693970000089 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693970000090 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 693970000091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693970000092 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 693970000093 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 693970000094 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970000095 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693970000096 Coenzyme A binding pocket [chemical binding]; other site 693970000097 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 693970000098 RecT family; Region: RecT; cl04285 693970000099 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693970000100 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693970000101 catalytic residue [active] 693970000102 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 693970000103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 693970000104 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 693970000105 active site 693970000106 metal binding site [ion binding]; metal-binding site 693970000107 interdomain interaction site; other site 693970000108 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 693970000109 metal ion-dependent adhesion site (MIDAS); other site 693970000110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970000111 Walker A motif; other site 693970000112 ATP binding site [chemical binding]; other site 693970000113 Walker B motif; other site 693970000114 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 693970000115 TraY domain; Region: TraY; cl17675 693970000116 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693970000117 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 693970000118 catalytic residues [active] 693970000119 catalytic nucleophile [active] 693970000120 Presynaptic Site I dimer interface [polypeptide binding]; other site 693970000121 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 693970000122 Synaptic Flat tetramer interface [polypeptide binding]; other site 693970000123 Synaptic Site I dimer interface [polypeptide binding]; other site 693970000124 DNA binding site [nucleotide binding] 693970000125 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 693970000126 DNA-binding interface [nucleotide binding]; DNA binding site 693970000127 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 693970000128 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 693970000129 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 693970000130 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 693970000131 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 693970000132 DNA topoisomerase III; Provisional; Region: PRK07726 693970000133 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 693970000134 active site 693970000135 putative interdomain interaction site [polypeptide binding]; other site 693970000136 putative metal-binding site [ion binding]; other site 693970000137 putative nucleotide binding site [chemical binding]; other site 693970000138 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 693970000139 domain I; other site 693970000140 DNA binding groove [nucleotide binding] 693970000141 phosphate binding site [ion binding]; other site 693970000142 domain II; other site 693970000143 domain III; other site 693970000144 nucleotide binding site [chemical binding]; other site 693970000145 catalytic site [active] 693970000146 domain IV; other site 693970000147 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693970000148 dimer interface [polypeptide binding]; other site 693970000149 ssDNA binding site [nucleotide binding]; other site 693970000150 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693970000151 Protein of unknown function, DUF417; Region: DUF417; cl01162 693970000152 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 693970000153 Homeodomain-like domain; Region: HTH_32; pfam13565 693970000154 threonine-tRNA ligase; Region: PLN02837 693970000155 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693970000156 active site 693970000157 catalytic residues [active] 693970000158 DNA binding site [nucleotide binding] 693970000159 Int/Topo IB signature motif; other site 693970000160 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 693970000161 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 693970000162 DNA binding domain, excisionase family; Region: excise; TIGR01764 693970000163 PIN domain; Region: PIN_3; pfam13470 693970000164 Transposase, Mutator family; Region: Transposase_mut; pfam00872 693970000165 MULE transposase domain; Region: MULE; pfam10551 693970000166 Scavenger mRNA decapping enzyme C-term binding; Region: DcpS_C; pfam11969 693970000167 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970000168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970000169 Walker A motif; other site 693970000170 ATP binding site [chemical binding]; other site 693970000171 Walker B motif; other site 693970000172 Transposase; Region: HTH_Tnp_1; cl17663 693970000173 Winged helix-turn helix; Region: HTH_29; pfam13551 693970000174 Homeodomain-like domain; Region: HTH_32; pfam13565 693970000175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970000176 Integrase core domain; Region: rve; pfam00665 693970000177 Integrase core domain; Region: rve_3; pfam13683 693970000178 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 693970000179 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970000180 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693970000181 dimerization interface [polypeptide binding]; other site 693970000182 Transposase; Region: HTH_Tnp_1; pfam01527 693970000183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970000184 putative transposase OrfB; Reviewed; Region: PHA02517 693970000185 HTH-like domain; Region: HTH_21; pfam13276 693970000186 Integrase core domain; Region: rve; pfam00665 693970000187 Integrase core domain; Region: rve_2; pfam13333 693970000188 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 693970000189 NADH(P)-binding; Region: NAD_binding_10; pfam13460 693970000190 NAD(P) binding site [chemical binding]; other site 693970000191 putative active site [active] 693970000192 multiple promoter invertase; Provisional; Region: mpi; PRK13413 693970000193 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 693970000194 catalytic residues [active] 693970000195 catalytic nucleophile [active] 693970000196 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 693970000197 HsdM N-terminal domain; Region: HsdM_N; pfam12161 693970000198 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 693970000199 Methyltransferase domain; Region: Methyltransf_26; pfam13659 693970000200 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 693970000201 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 693970000202 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 693970000203 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 693970000204 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 693970000205 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693970000206 ATP binding site [chemical binding]; other site 693970000207 putative Mg++ binding site [ion binding]; other site 693970000208 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 693970000209 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 693970000210 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 693970000211 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 693970000212 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 693970000213 putative active site [active] 693970000214 putative NTP binding site [chemical binding]; other site 693970000215 putative nucleic acid binding site [nucleotide binding]; other site 693970000216 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 693970000217 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 693970000218 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 693970000219 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693970000220 ligand binding site [chemical binding]; other site 693970000221 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693970000222 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 693970000223 catalytic residues [active] 693970000224 catalytic nucleophile [active] 693970000225 Abi-like protein; Region: Abi_2; pfam07751 693970000226 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 693970000227 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 693970000228 Integrase core domain; Region: rve; pfam00665 693970000229 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970000230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970000231 Walker A motif; other site 693970000232 ATP binding site [chemical binding]; other site 693970000233 Walker B motif; other site 693970000234 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693970000235 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693970000236 P-loop; other site 693970000237 Magnesium ion binding site [ion binding]; other site 693970000238 Hok/gef family; Region: HOK_GEF; pfam01848 693970000239 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693970000240 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970000241 non-specific DNA binding site [nucleotide binding]; other site 693970000242 salt bridge; other site 693970000243 sequence-specific DNA binding site [nucleotide binding]; other site 693970000244 Predicted transcriptional regulator [Transcription]; Region: COG2932 693970000245 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693970000246 Catalytic site [active] 693970000247 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 693970000248 DnaA N-terminal domain; Region: DnaA_N; pfam11638 693970000249 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 693970000250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970000251 Walker A motif; other site 693970000252 ATP binding site [chemical binding]; other site 693970000253 Walker B motif; other site 693970000254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 693970000255 arginine finger; other site 693970000256 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 693970000257 DnaA box-binding interface [nucleotide binding]; other site 693970000258 DNA polymerase III subunit beta; Validated; Region: PRK05643 693970000259 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 693970000260 putative DNA binding surface [nucleotide binding]; other site 693970000261 dimer interface [polypeptide binding]; other site 693970000262 beta-clamp/clamp loader binding surface; other site 693970000263 beta-clamp/translesion DNA polymerase binding surface; other site 693970000264 recombination protein F; Reviewed; Region: recF; PRK00064 693970000265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970000266 Walker A/P-loop; other site 693970000267 ATP binding site [chemical binding]; other site 693970000268 Q-loop/lid; other site 693970000269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970000270 ABC transporter signature motif; other site 693970000271 Walker B; other site 693970000272 D-loop; other site 693970000273 H-loop/switch region; other site 693970000274 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 693970000275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970000276 ATP binding site [chemical binding]; other site 693970000277 Mg2+ binding site [ion binding]; other site 693970000278 G-X-G motif; other site 693970000279 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 693970000280 anchoring element; other site 693970000281 dimer interface [polypeptide binding]; other site 693970000282 ATP binding site [chemical binding]; other site 693970000283 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 693970000284 active site 693970000285 putative metal-binding site [ion binding]; other site 693970000286 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 693970000287 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 693970000288 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693970000289 putative C-terminal domain interface [polypeptide binding]; other site 693970000290 putative GSH binding site (G-site) [chemical binding]; other site 693970000291 putative dimer interface [polypeptide binding]; other site 693970000292 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 693970000293 putative N-terminal domain interface [polypeptide binding]; other site 693970000294 putative dimer interface [polypeptide binding]; other site 693970000295 putative substrate binding pocket (H-site) [chemical binding]; other site 693970000296 Cytochrome c; Region: Cytochrom_C; cl11414 693970000297 sulfite oxidase; Provisional; Region: PLN00177 693970000298 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 693970000299 Moco binding site; other site 693970000300 metal coordination site [ion binding]; other site 693970000301 dimerization interface [polypeptide binding]; other site 693970000302 Cytochrome c; Region: Cytochrom_C; cl11414 693970000303 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 693970000304 HDOD domain; Region: HDOD; pfam08668 693970000305 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693970000306 Zn2+ binding site [ion binding]; other site 693970000307 Mg2+ binding site [ion binding]; other site 693970000308 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 693970000309 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 693970000310 dimer interface [polypeptide binding]; other site 693970000311 motif 1; other site 693970000312 active site 693970000313 motif 2; other site 693970000314 motif 3; other site 693970000315 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 693970000316 MOSC domain; Region: MOSC; pfam03473 693970000317 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 693970000318 CPxP motif; other site 693970000319 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 693970000320 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693970000321 dimer interface [polypeptide binding]; other site 693970000322 active site 693970000323 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 693970000324 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693970000325 substrate binding site [chemical binding]; other site 693970000326 oxyanion hole (OAH) forming residues; other site 693970000327 trimer interface [polypeptide binding]; other site 693970000328 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693970000329 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693970000330 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693970000331 proline dipeptidase; Provisional; Region: PRK13607 693970000332 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 693970000333 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 693970000334 active site 693970000335 Cation transport protein; Region: TrkH; cl17365 693970000336 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 693970000337 Flavodoxin domain; Region: Flavodoxin_5; cl17428 693970000338 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693970000339 dimerization interface [polypeptide binding]; other site 693970000340 putative DNA binding site [nucleotide binding]; other site 693970000341 putative Zn2+ binding site [ion binding]; other site 693970000342 Flavodoxin domain; Region: Flavodoxin_5; cl17428 693970000343 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 693970000344 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 693970000345 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 693970000346 TrkA-N domain; Region: TrkA_N; pfam02254 693970000347 TrkA-C domain; Region: TrkA_C; pfam02080 693970000348 TrkA-N domain; Region: TrkA_N; pfam02254 693970000349 TrkA-C domain; Region: TrkA_C; pfam02080 693970000350 16S rRNA methyltransferase B; Provisional; Region: PRK10901 693970000351 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 693970000352 putative RNA binding site [nucleotide binding]; other site 693970000353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970000354 S-adenosylmethionine binding site [chemical binding]; other site 693970000355 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 693970000356 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 693970000357 putative active site [active] 693970000358 substrate binding site [chemical binding]; other site 693970000359 putative cosubstrate binding site; other site 693970000360 catalytic site [active] 693970000361 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 693970000362 substrate binding site [chemical binding]; other site 693970000363 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 693970000364 active site 693970000365 catalytic residues [active] 693970000366 metal binding site [ion binding]; metal-binding site 693970000367 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693970000368 DNA protecting protein DprA; Region: dprA; TIGR00732 693970000369 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 693970000370 Protein of unknown function (DUF494); Region: DUF494; pfam04361 693970000371 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693970000372 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693970000373 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693970000374 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 693970000375 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 693970000376 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 693970000377 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 693970000378 apolar tunnel; other site 693970000379 heme binding site [chemical binding]; other site 693970000380 dimerization interface [polypeptide binding]; other site 693970000381 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 693970000382 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 693970000383 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 693970000384 shikimate binding site; other site 693970000385 NAD(P) binding site [chemical binding]; other site 693970000386 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 693970000387 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 693970000388 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 693970000389 trimer interface [polypeptide binding]; other site 693970000390 putative metal binding site [ion binding]; other site 693970000391 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970000392 PAS fold; Region: PAS_3; pfam08447 693970000393 putative active site [active] 693970000394 heme pocket [chemical binding]; other site 693970000395 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970000396 metal binding site [ion binding]; metal-binding site 693970000397 active site 693970000398 I-site; other site 693970000399 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970000400 lysophospholipase L2; Provisional; Region: PRK10749 693970000401 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693970000402 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 693970000403 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 693970000404 adenosine deaminase; Provisional; Region: PRK09358 693970000405 active site 693970000406 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 693970000407 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693970000408 FeS/SAM binding site; other site 693970000409 HemN C-terminal domain; Region: HemN_C; pfam06969 693970000410 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 693970000411 Der GTPase activator (YihI); Region: YihI; pfam04220 693970000412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693970000413 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693970000414 Cytochrome c553 [Energy production and conversion]; Region: COG2863 693970000415 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693970000416 Cytochrome c; Region: Cytochrom_C; cl11414 693970000417 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 693970000418 G1 box; other site 693970000419 GTP/Mg2+ binding site [chemical binding]; other site 693970000420 Switch I region; other site 693970000421 G2 box; other site 693970000422 G3 box; other site 693970000423 Switch II region; other site 693970000424 G4 box; other site 693970000425 G5 box; other site 693970000426 DNA polymerase I; Provisional; Region: PRK05755 693970000427 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 693970000428 active site 693970000429 metal binding site 1 [ion binding]; metal-binding site 693970000430 putative 5' ssDNA interaction site; other site 693970000431 metal binding site 3; metal-binding site 693970000432 metal binding site 2 [ion binding]; metal-binding site 693970000433 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 693970000434 putative DNA binding site [nucleotide binding]; other site 693970000435 putative metal binding site [ion binding]; other site 693970000436 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 693970000437 active site 693970000438 catalytic site [active] 693970000439 substrate binding site [chemical binding]; other site 693970000440 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 693970000441 active site 693970000442 DNA binding site [nucleotide binding] 693970000443 catalytic site [active] 693970000444 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 693970000445 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 693970000446 conserved cys residue [active] 693970000447 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 693970000448 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 693970000449 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 693970000450 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 693970000451 active site residue [active] 693970000452 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 693970000453 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 693970000454 NAD(P) binding site [chemical binding]; other site 693970000455 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 693970000456 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 693970000457 substrate-cofactor binding pocket; other site 693970000458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970000459 catalytic residue [active] 693970000460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693970000461 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693970000462 Bacterial transcriptional repressor; Region: TetR; pfam13972 693970000463 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 693970000464 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 693970000465 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 693970000466 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293 693970000467 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 693970000468 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 693970000469 putative active site [active] 693970000470 conserved hypothetical protein; Region: MJ1255; TIGR00661 693970000471 Beta-1,4-N-acetylgalactosaminyltransferase (CgtA); Region: CgtA; pfam06306 693970000472 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693970000473 active site 693970000474 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693970000475 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 693970000476 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 693970000477 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 693970000478 active site 693970000479 homodimer interface [polypeptide binding]; other site 693970000480 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 693970000481 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 693970000482 active site 693970000483 (T/H)XGH motif; other site 693970000484 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 693970000485 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693970000486 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 693970000487 putative NAD(P) binding site [chemical binding]; other site 693970000488 active site 693970000489 putative substrate binding site [chemical binding]; other site 693970000490 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 693970000491 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 693970000492 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 693970000493 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 693970000494 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 693970000495 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 693970000496 Ligand binding site; other site 693970000497 Putative Catalytic site; other site 693970000498 DXD motif; other site 693970000499 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 693970000500 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 693970000501 DNA binding site [nucleotide binding] 693970000502 catalytic residue [active] 693970000503 H2TH interface [polypeptide binding]; other site 693970000504 putative catalytic residues [active] 693970000505 turnover-facilitating residue; other site 693970000506 intercalation triad [nucleotide binding]; other site 693970000507 8OG recognition residue [nucleotide binding]; other site 693970000508 putative reading head residues; other site 693970000509 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 693970000510 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 693970000511 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 693970000512 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693970000513 FeS/SAM binding site; other site 693970000514 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 693970000515 putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional; Region: PRK14491 693970000516 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 693970000517 Walker A motif; other site 693970000518 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 693970000519 dimer interface [polypeptide binding]; other site 693970000520 putative functional site; other site 693970000521 putative MPT binding site; other site 693970000522 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 693970000523 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 693970000524 GTP binding site; other site 693970000525 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 693970000526 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970000527 Walker A/P-loop; other site 693970000528 ATP binding site [chemical binding]; other site 693970000529 Q-loop/lid; other site 693970000530 ABC transporter signature motif; other site 693970000531 Walker B; other site 693970000532 D-loop; other site 693970000533 H-loop/switch region; other site 693970000534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693970000535 dimer interface [polypeptide binding]; other site 693970000536 conserved gate region; other site 693970000537 putative PBP binding loops; other site 693970000538 ABC-ATPase subunit interface; other site 693970000539 PBP superfamily domain; Region: PBP_like_2; pfam12849 693970000540 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 693970000541 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 693970000542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970000543 active site 693970000544 phosphorylation site [posttranslational modification] 693970000545 intermolecular recognition site; other site 693970000546 dimerization interface [polypeptide binding]; other site 693970000547 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970000548 Walker A motif; other site 693970000549 ATP binding site [chemical binding]; other site 693970000550 Walker B motif; other site 693970000551 arginine finger; other site 693970000552 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693970000553 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693970000554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970000555 dimer interface [polypeptide binding]; other site 693970000556 phosphorylation site [posttranslational modification] 693970000557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970000558 ATP binding site [chemical binding]; other site 693970000559 G-X-G motif; other site 693970000560 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970000561 Coenzyme A binding pocket [chemical binding]; other site 693970000562 hypothetical protein; Provisional; Region: PRK11212 693970000563 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 693970000564 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 693970000565 chorismate binding enzyme; Region: Chorismate_bind; cl10555 693970000566 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970000567 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970000568 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 693970000569 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 693970000570 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 693970000571 Walker A/P-loop; other site 693970000572 ATP binding site [chemical binding]; other site 693970000573 Q-loop/lid; other site 693970000574 ABC transporter signature motif; other site 693970000575 Walker B; other site 693970000576 D-loop; other site 693970000577 H-loop/switch region; other site 693970000578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970000579 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 693970000580 Walker A/P-loop; other site 693970000581 ATP binding site [chemical binding]; other site 693970000582 Q-loop/lid; other site 693970000583 ABC transporter signature motif; other site 693970000584 Walker B; other site 693970000585 D-loop; other site 693970000586 H-loop/switch region; other site 693970000587 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 693970000588 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 693970000589 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 693970000590 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693970000591 Zn2+ binding site [ion binding]; other site 693970000592 Mg2+ binding site [ion binding]; other site 693970000593 Paraquat-inducible protein A; Region: PqiA; pfam04403 693970000594 Protein of unknown function (DUF3240); Region: DUF3240; pfam11582 693970000595 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 693970000596 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970000597 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693970000598 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 693970000599 DNA binding residues [nucleotide binding] 693970000600 dimerization interface [polypeptide binding]; other site 693970000601 Predicted membrane protein [Function unknown]; Region: COG2855 693970000602 malate synthase; Provisional; Region: PRK08951 693970000603 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693970000604 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970000605 non-specific DNA binding site [nucleotide binding]; other site 693970000606 salt bridge; other site 693970000607 sequence-specific DNA binding site [nucleotide binding]; other site 693970000608 Protein of unknown function (DUF3612); Region: DUF3612; pfam12268 693970000609 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 693970000610 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 693970000611 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 693970000612 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 693970000613 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693970000614 Protein export membrane protein; Region: SecD_SecF; cl14618 693970000615 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693970000616 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693970000617 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970000618 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 693970000619 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 693970000620 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693970000621 N-terminal plug; other site 693970000622 ligand-binding site [chemical binding]; other site 693970000623 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 693970000624 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 693970000625 putative catalytic cysteine [active] 693970000626 gamma-glutamyl kinase; Provisional; Region: PRK13402 693970000627 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 693970000628 nucleotide binding site [chemical binding]; other site 693970000629 homotetrameric interface [polypeptide binding]; other site 693970000630 putative phosphate binding site [ion binding]; other site 693970000631 putative allosteric binding site; other site 693970000632 PUA domain; Region: PUA; cl00607 693970000633 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 693970000634 Na binding site [ion binding]; other site 693970000635 Fusaric acid resistance protein family; Region: FUSC; pfam04632 693970000636 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 693970000637 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 693970000638 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693970000639 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970000640 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 693970000641 glutathione reductase; Validated; Region: PRK06116 693970000642 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693970000643 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693970000644 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 693970000645 oligopeptidase A; Provisional; Region: PRK10911 693970000646 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 693970000647 active site 693970000648 Zn binding site [ion binding]; other site 693970000649 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693970000650 active site 693970000651 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693970000652 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 693970000653 C-terminal domain interface [polypeptide binding]; other site 693970000654 GSH binding site (G-site) [chemical binding]; other site 693970000655 dimer interface [polypeptide binding]; other site 693970000656 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 693970000657 N-terminal domain interface [polypeptide binding]; other site 693970000658 dimer interface [polypeptide binding]; other site 693970000659 substrate binding pocket (H-site) [chemical binding]; other site 693970000660 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 693970000661 conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001 693970000662 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 693970000663 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693970000664 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970000665 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 693970000666 Protein export membrane protein; Region: SecD_SecF; cl14618 693970000667 AbgT putative transporter family; Region: ABG_transport; pfam03806 693970000668 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 693970000669 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 693970000670 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 693970000671 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 693970000672 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693970000673 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693970000674 catalytic residue [active] 693970000675 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 693970000676 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970000677 metal binding site [ion binding]; metal-binding site 693970000678 active site 693970000679 I-site; other site 693970000680 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970000681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970000682 S-adenosylmethionine binding site [chemical binding]; other site 693970000683 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 693970000684 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 693970000685 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 693970000686 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 693970000687 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 693970000688 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 693970000689 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 693970000690 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 693970000691 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 693970000692 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 693970000693 Secretin and TonB N terminus short domain; Region: STN; smart00965 693970000694 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 693970000695 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693970000696 N-terminal plug; other site 693970000697 ligand-binding site [chemical binding]; other site 693970000698 fec operon regulator FecR; Reviewed; Region: PRK09774 693970000699 FecR protein; Region: FecR; pfam04773 693970000700 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693970000701 RNA polymerase sigma factor; Provisional; Region: PRK12528 693970000702 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693970000703 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693970000704 DNA binding residues [nucleotide binding] 693970000705 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 693970000706 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693970000707 substrate binding pocket [chemical binding]; other site 693970000708 membrane-bound complex binding site; other site 693970000709 hinge residues; other site 693970000710 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 693970000711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970000712 Walker A/P-loop; other site 693970000713 ATP binding site [chemical binding]; other site 693970000714 Q-loop/lid; other site 693970000715 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693970000716 ABC transporter; Region: ABC_tran_2; pfam12848 693970000717 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693970000718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970000719 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693970000720 putative substrate translocation pore; other site 693970000721 Methyltransferase domain; Region: Methyltransf_12; pfam08242 693970000722 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 693970000723 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 693970000724 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 693970000725 trimer interface [polypeptide binding]; other site 693970000726 active site 693970000727 substrate binding site [chemical binding]; other site 693970000728 CoA binding site [chemical binding]; other site 693970000729 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970000730 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970000731 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 693970000732 putative effector binding pocket; other site 693970000733 putative dimerization interface [polypeptide binding]; other site 693970000734 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 693970000735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693970000736 NAD(P) binding site [chemical binding]; other site 693970000737 active site 693970000738 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 693970000739 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 693970000740 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 693970000741 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 693970000742 DsbD alpha interface [polypeptide binding]; other site 693970000743 catalytic residues [active] 693970000744 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 693970000745 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693970000746 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 693970000747 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693970000748 catalytic residues [active] 693970000749 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 693970000750 UbiA prenyltransferase family; Region: UbiA; pfam01040 693970000751 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 693970000752 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 693970000753 Subunit I/III interface [polypeptide binding]; other site 693970000754 Subunit III/IV interface [polypeptide binding]; other site 693970000755 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 693970000756 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 693970000757 D-pathway; other site 693970000758 Putative ubiquinol binding site [chemical binding]; other site 693970000759 Low-spin heme (heme b) binding site [chemical binding]; other site 693970000760 Putative water exit pathway; other site 693970000761 Binuclear center (heme o3/CuB) [ion binding]; other site 693970000762 K-pathway; other site 693970000763 Putative proton exit pathway; other site 693970000764 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 693970000765 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 693970000766 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 693970000767 MASE1; Region: MASE1; cl17823 693970000768 CHASE domain; Region: CHASE; pfam03924 693970000769 PAS domain S-box; Region: sensory_box; TIGR00229 693970000770 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970000771 putative active site [active] 693970000772 heme pocket [chemical binding]; other site 693970000773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970000774 PAS domain; Region: PAS_9; pfam13426 693970000775 putative active site [active] 693970000776 heme pocket [chemical binding]; other site 693970000777 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970000778 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970000779 metal binding site [ion binding]; metal-binding site 693970000780 active site 693970000781 I-site; other site 693970000782 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970000783 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 693970000784 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 693970000785 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 693970000786 dimer interface [polypeptide binding]; other site 693970000787 phosphorylation site [posttranslational modification] 693970000788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970000789 ATP binding site [chemical binding]; other site 693970000790 Mg2+ binding site [ion binding]; other site 693970000791 G-X-G motif; other site 693970000792 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693970000793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970000794 active site 693970000795 phosphorylation site [posttranslational modification] 693970000796 intermolecular recognition site; other site 693970000797 dimerization interface [polypeptide binding]; other site 693970000798 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693970000799 DNA binding site [nucleotide binding] 693970000800 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 693970000801 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 693970000802 catalytic triad [active] 693970000803 dimer interface [polypeptide binding]; other site 693970000804 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693970000805 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970000806 dimerization interface [polypeptide binding]; other site 693970000807 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970000808 dimer interface [polypeptide binding]; other site 693970000809 putative CheW interface [polypeptide binding]; other site 693970000810 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 693970000811 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970000812 dimerization interface [polypeptide binding]; other site 693970000813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970000814 dimer interface [polypeptide binding]; other site 693970000815 phosphorylation site [posttranslational modification] 693970000816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970000817 ATP binding site [chemical binding]; other site 693970000818 Mg2+ binding site [ion binding]; other site 693970000819 G-X-G motif; other site 693970000820 osmolarity response regulator; Provisional; Region: ompR; PRK09468 693970000821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970000822 active site 693970000823 phosphorylation site [posttranslational modification] 693970000824 intermolecular recognition site; other site 693970000825 dimerization interface [polypeptide binding]; other site 693970000826 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693970000827 DNA binding site [nucleotide binding] 693970000828 CHASE domain; Region: CHASE; pfam03924 693970000829 PAS domain S-box; Region: sensory_box; TIGR00229 693970000830 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970000831 putative active site [active] 693970000832 heme pocket [chemical binding]; other site 693970000833 PAS domain; Region: PAS_9; pfam13426 693970000834 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970000835 putative active site [active] 693970000836 heme pocket [chemical binding]; other site 693970000837 PAS domain; Region: PAS_9; pfam13426 693970000838 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970000839 putative active site [active] 693970000840 heme pocket [chemical binding]; other site 693970000841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970000842 PAS fold; Region: PAS_3; pfam08447 693970000843 putative active site [active] 693970000844 heme pocket [chemical binding]; other site 693970000845 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693970000846 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970000847 dimer interface [polypeptide binding]; other site 693970000848 phosphorylation site [posttranslational modification] 693970000849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970000850 ATP binding site [chemical binding]; other site 693970000851 Mg2+ binding site [ion binding]; other site 693970000852 G-X-G motif; other site 693970000853 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693970000854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970000855 active site 693970000856 phosphorylation site [posttranslational modification] 693970000857 intermolecular recognition site; other site 693970000858 dimerization interface [polypeptide binding]; other site 693970000859 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693970000860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970000861 active site 693970000862 phosphorylation site [posttranslational modification] 693970000863 intermolecular recognition site; other site 693970000864 dimerization interface [polypeptide binding]; other site 693970000865 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 693970000866 Response regulator receiver domain; Region: Response_reg; pfam00072 693970000867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970000868 active site 693970000869 phosphorylation site [posttranslational modification] 693970000870 intermolecular recognition site; other site 693970000871 dimerization interface [polypeptide binding]; other site 693970000872 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970000873 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970000874 metal binding site [ion binding]; metal-binding site 693970000875 active site 693970000876 I-site; other site 693970000877 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 693970000878 Protein kinase domain; Region: Pkinase; pfam00069 693970000879 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 693970000880 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693970000881 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693970000882 DNA binding site [nucleotide binding] 693970000883 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145 693970000884 Transposase; Region: HTH_Tnp_1; pfam01527 693970000885 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970000886 putative transposase OrfB; Reviewed; Region: PHA02517 693970000887 HTH-like domain; Region: HTH_21; pfam13276 693970000888 Integrase core domain; Region: rve; pfam00665 693970000889 Integrase core domain; Region: rve_2; pfam13333 693970000890 type III secretion system protein YscR; Provisional; Region: PRK12797 693970000891 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 693970000892 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 693970000893 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 693970000894 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 693970000895 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693970000896 Walker A motif; other site 693970000897 ATP binding site [chemical binding]; other site 693970000898 Walker B motif; other site 693970000899 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 693970000900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 693970000901 binding surface 693970000902 TPR motif; other site 693970000903 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693970000904 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 693970000905 FHIPEP family; Region: FHIPEP; pfam00771 693970000906 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 693970000907 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 693970000908 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693970000909 ligand binding site [chemical binding]; other site 693970000910 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 693970000911 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 693970000912 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693970000913 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693970000914 DNA binding site [nucleotide binding] 693970000915 Winged helix-turn helix; Region: HTH_29; pfam13551 693970000916 Homeodomain-like domain; Region: HTH_32; pfam13565 693970000917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970000918 Integrase core domain; Region: rve; pfam00665 693970000919 Integrase core domain; Region: rve_3; pfam13683 693970000920 Transposase; Region: HTH_Tnp_1; cl17663 693970000921 Integrase core domain; Region: rve; pfam00665 693970000922 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970000923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970000924 Walker A motif; other site 693970000925 ATP binding site [chemical binding]; other site 693970000926 Walker B motif; other site 693970000927 Transposase; Region: HTH_Tnp_1; pfam01527 693970000928 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970000929 putative transposase OrfB; Reviewed; Region: PHA02517 693970000930 HTH-like domain; Region: HTH_21; pfam13276 693970000931 Integrase core domain; Region: rve; pfam00665 693970000932 Integrase core domain; Region: rve_2; pfam13333 693970000933 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 693970000934 active site 693970000935 catalytic triad [active] 693970000936 oxyanion hole [active] 693970000937 Rho-activating domain of cytotoxic necrotizing factor; Region: CNF1; pfam05785 693970000938 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 693970000939 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 693970000940 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693970000941 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 693970000942 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 693970000943 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 693970000944 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 693970000945 RNA binding site [nucleotide binding]; other site 693970000946 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 693970000947 Sulfatase; Region: Sulfatase; pfam00884 693970000948 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 693970000949 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 693970000950 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 693970000951 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 693970000952 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 693970000953 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 693970000954 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693970000955 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 693970000956 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 693970000957 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973 693970000958 putative active site [active] 693970000959 putative metal binding site [ion binding]; other site 693970000960 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 693970000961 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 693970000962 Cu(I) binding site [ion binding]; other site 693970000963 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 693970000964 UbiA prenyltransferase family; Region: UbiA; pfam01040 693970000965 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 693970000966 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 693970000967 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 693970000968 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 693970000969 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 693970000970 Subunit III/VIIa interface [polypeptide binding]; other site 693970000971 Phospholipid binding site [chemical binding]; other site 693970000972 Subunit I/III interface [polypeptide binding]; other site 693970000973 Subunit III/VIb interface [polypeptide binding]; other site 693970000974 Subunit III/VIa interface; other site 693970000975 Subunit III/Vb interface [polypeptide binding]; other site 693970000976 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 693970000977 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 693970000978 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 693970000979 Subunit I/III interface [polypeptide binding]; other site 693970000980 D-pathway; other site 693970000981 Subunit I/VIIc interface [polypeptide binding]; other site 693970000982 Subunit I/IV interface [polypeptide binding]; other site 693970000983 Subunit I/II interface [polypeptide binding]; other site 693970000984 Low-spin heme (heme a) binding site [chemical binding]; other site 693970000985 Subunit I/VIIa interface [polypeptide binding]; other site 693970000986 Subunit I/VIa interface [polypeptide binding]; other site 693970000987 Dimer interface; other site 693970000988 Putative water exit pathway; other site 693970000989 Binuclear center (heme a3/CuB) [ion binding]; other site 693970000990 K-pathway; other site 693970000991 Subunit I/Vb interface [polypeptide binding]; other site 693970000992 Putative proton exit pathway; other site 693970000993 Subunit I/VIb interface; other site 693970000994 Subunit I/VIc interface [polypeptide binding]; other site 693970000995 Electron transfer pathway; other site 693970000996 Subunit I/VIIIb interface [polypeptide binding]; other site 693970000997 Subunit I/VIIb interface [polypeptide binding]; other site 693970000998 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 693970000999 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00038 693970001000 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 693970001001 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693970001002 Cytochrome c; Region: Cytochrom_C; pfam00034 693970001003 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693970001004 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 693970001005 Cell division inhibitor SulA; Region: SulA; cl01880 693970001006 LexA repressor; Validated; Region: PRK00215 693970001007 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 693970001008 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693970001009 Catalytic site [active] 693970001010 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 693970001011 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 693970001012 putative acyl-acceptor binding pocket; other site 693970001013 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 693970001014 aromatic amino acid transport protein; Region: araaP; TIGR00837 693970001015 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 693970001016 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 693970001017 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693970001018 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970001019 dimerization interface [polypeptide binding]; other site 693970001020 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693970001021 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970001022 dimer interface [polypeptide binding]; other site 693970001023 putative CheW interface [polypeptide binding]; other site 693970001024 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 693970001025 B1 nucleotide binding pocket [chemical binding]; other site 693970001026 B2 nucleotide binding pocket [chemical binding]; other site 693970001027 CAS motifs; other site 693970001028 active site 693970001029 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 693970001030 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693970001031 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970001032 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 693970001033 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 693970001034 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 693970001035 Protein of unknown function (DUF1145); Region: DUF1145; pfam06611 693970001036 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 693970001037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970001038 S-adenosylmethionine binding site [chemical binding]; other site 693970001039 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 693970001040 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 693970001041 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 693970001042 P loop; other site 693970001043 GTP binding site [chemical binding]; other site 693970001044 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 693970001045 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970001046 Walker A/P-loop; other site 693970001047 ATP binding site [chemical binding]; other site 693970001048 Q-loop/lid; other site 693970001049 ABC transporter signature motif; other site 693970001050 Walker B; other site 693970001051 D-loop; other site 693970001052 H-loop/switch region; other site 693970001053 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 693970001054 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 693970001055 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 693970001056 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693970001057 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693970001058 DNA binding residues [nucleotide binding] 693970001059 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 693970001060 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 693970001061 acyl-activating enzyme (AAE) consensus motif; other site 693970001062 putative AMP binding site [chemical binding]; other site 693970001063 putative active site [active] 693970001064 putative CoA binding site [chemical binding]; other site 693970001065 O-succinylbenzoate synthase; Provisional; Region: PRK05105 693970001066 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 693970001067 active site 693970001068 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 693970001069 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 693970001070 nucleophilic elbow; other site 693970001071 catalytic triad; other site 693970001072 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 693970001073 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 693970001074 dimer interface [polypeptide binding]; other site 693970001075 tetramer interface [polypeptide binding]; other site 693970001076 PYR/PP interface [polypeptide binding]; other site 693970001077 TPP binding site [chemical binding]; other site 693970001078 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693970001079 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 693970001080 TPP-binding site; other site 693970001081 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970001082 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970001083 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693970001084 dimerization interface [polypeptide binding]; other site 693970001085 radical SAM peptide maturase, FibroRumin system; Region: rSAM_FibroRumin; TIGR04136 693970001086 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 693970001087 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 693970001088 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 693970001089 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 693970001090 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 693970001091 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693970001092 dimerization interface [polypeptide binding]; other site 693970001093 putative Zn2+ binding site [ion binding]; other site 693970001094 putative DNA binding site [nucleotide binding]; other site 693970001095 AsnC family; Region: AsnC_trans_reg; pfam01037 693970001096 Spore germination protein; Region: Spore_permease; cl17796 693970001097 putative transporter; Provisional; Region: PRK11021 693970001098 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 693970001099 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 693970001100 HDOD domain; Region: HDOD; pfam08668 693970001101 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 693970001102 putative metal binding site [ion binding]; other site 693970001103 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 693970001104 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 693970001105 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693970001106 Sel1-like repeats; Region: SEL1; smart00671 693970001107 Cache domain; Region: Cache_1; pfam02743 693970001108 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970001109 dimerization interface [polypeptide binding]; other site 693970001110 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970001111 dimer interface [polypeptide binding]; other site 693970001112 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 693970001113 putative CheW interface [polypeptide binding]; other site 693970001114 Cache domain; Region: Cache_1; pfam02743 693970001115 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970001116 dimerization interface [polypeptide binding]; other site 693970001117 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970001118 dimer interface [polypeptide binding]; other site 693970001119 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 693970001120 putative CheW interface [polypeptide binding]; other site 693970001121 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 693970001122 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970001123 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 693970001124 substrate binding pocket [chemical binding]; other site 693970001125 dimerization interface [polypeptide binding]; other site 693970001126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970001127 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 693970001128 putative substrate translocation pore; other site 693970001129 DTW domain; Region: DTW; cl01221 693970001130 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970001131 PAS domain; Region: PAS_9; pfam13426 693970001132 putative active site [active] 693970001133 heme pocket [chemical binding]; other site 693970001134 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970001135 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970001136 metal binding site [ion binding]; metal-binding site 693970001137 active site 693970001138 I-site; other site 693970001139 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970001140 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693970001141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970001142 S-adenosylmethionine binding site [chemical binding]; other site 693970001143 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 693970001144 NIPSNAP; Region: NIPSNAP; pfam07978 693970001145 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693970001146 dimerization interface [polypeptide binding]; other site 693970001147 putative DNA binding site [nucleotide binding]; other site 693970001148 putative Zn2+ binding site [ion binding]; other site 693970001149 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 693970001150 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 693970001151 metal binding site [ion binding]; metal-binding site 693970001152 putative dimer interface [polypeptide binding]; other site 693970001153 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693970001154 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693970001155 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693970001156 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693970001157 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693970001158 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693970001159 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 693970001160 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693970001161 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693970001162 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 693970001163 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 693970001164 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 693970001165 substrate binding pocket [chemical binding]; other site 693970001166 membrane-bound complex binding site; other site 693970001167 hinge residues; other site 693970001168 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693970001169 EamA-like transporter family; Region: EamA; pfam00892 693970001170 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 693970001171 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970001172 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 693970001173 substrate binding pocket [chemical binding]; other site 693970001174 dimerization interface [polypeptide binding]; other site 693970001175 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 693970001176 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 693970001177 active site 693970001178 nucleophile elbow; other site 693970001179 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970001180 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970001181 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693970001182 putative effector binding pocket; other site 693970001183 dimerization interface [polypeptide binding]; other site 693970001184 enterobactin receptor protein; Provisional; Region: PRK13483 693970001185 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693970001186 N-terminal plug; other site 693970001187 ligand-binding site [chemical binding]; other site 693970001188 Sec63 Brl domain; Region: Sec63; pfam02889 693970001189 coproporphyrinogen III oxidase; Provisional; Region: PRK08629 693970001190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693970001191 FeS/SAM binding site; other site 693970001192 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 693970001193 Sodium Bile acid symporter family; Region: SBF; pfam01758 693970001194 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693970001195 Sel1-like repeats; Region: SEL1; smart00671 693970001196 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 693970001197 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 693970001198 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 693970001199 heme exporter protein CcmC; Region: ccmC; TIGR01191 693970001200 CcmB protein; Region: CcmB; pfam03379 693970001201 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 693970001202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970001203 Walker A/P-loop; other site 693970001204 ATP binding site [chemical binding]; other site 693970001205 Q-loop/lid; other site 693970001206 ABC transporter signature motif; other site 693970001207 Walker B; other site 693970001208 D-loop; other site 693970001209 H-loop/switch region; other site 693970001210 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 693970001211 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 693970001212 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 693970001213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970001214 TPR motif; other site 693970001215 binding surface 693970001216 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 693970001217 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 693970001218 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 693970001219 catalytic residues [active] 693970001220 central insert; other site 693970001221 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 693970001222 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 693970001223 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693970001224 catalytic residues [active] 693970001225 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 693970001226 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693970001227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970001228 Coenzyme A binding pocket [chemical binding]; other site 693970001229 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693970001230 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 693970001231 dimer interface [polypeptide binding]; other site 693970001232 phosphorylation site [posttranslational modification] 693970001233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970001234 ATP binding site [chemical binding]; other site 693970001235 Mg2+ binding site [ion binding]; other site 693970001236 G-X-G motif; other site 693970001237 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693970001238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970001239 active site 693970001240 phosphorylation site [posttranslational modification] 693970001241 intermolecular recognition site; other site 693970001242 dimerization interface [polypeptide binding]; other site 693970001243 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693970001244 DNA binding site [nucleotide binding] 693970001245 Predicted membrane protein [Function unknown]; Region: COG3212 693970001246 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 693970001247 Dihaem cytochrome c; Region: DHC; pfam09626 693970001248 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 693970001249 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 693970001250 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 693970001251 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970001252 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970001253 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 693970001254 putative effector binding pocket; other site 693970001255 putative dimerization interface [polypeptide binding]; other site 693970001256 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 693970001257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693970001258 NAD(P) binding site [chemical binding]; other site 693970001259 active site 693970001260 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 693970001261 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693970001262 NAD(P) binding site [chemical binding]; other site 693970001263 catalytic residues [active] 693970001264 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 693970001265 GAF domain; Region: GAF; pfam01590 693970001266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970001267 Walker A motif; other site 693970001268 ATP binding site [chemical binding]; other site 693970001269 Walker B motif; other site 693970001270 arginine finger; other site 693970001271 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693970001272 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 693970001273 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 693970001274 NADP binding site [chemical binding]; other site 693970001275 dimer interface [polypeptide binding]; other site 693970001276 Winged helix-turn helix; Region: HTH_29; pfam13551 693970001277 Homeodomain-like domain; Region: HTH_32; pfam13565 693970001278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970001279 Integrase core domain; Region: rve; pfam00665 693970001280 Integrase core domain; Region: rve_3; pfam13683 693970001281 Transposase; Region: HTH_Tnp_1; cl17663 693970001282 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 693970001283 heme-binding residues [chemical binding]; other site 693970001284 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970001285 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970001286 LysR substrate binding domain; Region: LysR_substrate; pfam03466 693970001287 dimerization interface [polypeptide binding]; other site 693970001288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693970001289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693970001290 two-component sensor protein; Provisional; Region: cpxA; PRK09470 693970001291 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970001292 dimerization interface [polypeptide binding]; other site 693970001293 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970001294 dimer interface [polypeptide binding]; other site 693970001295 phosphorylation site [posttranslational modification] 693970001296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970001297 ATP binding site [chemical binding]; other site 693970001298 Mg2+ binding site [ion binding]; other site 693970001299 G-X-G motif; other site 693970001300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970001301 active site 693970001302 phosphorylation site [posttranslational modification] 693970001303 intermolecular recognition site; other site 693970001304 dimerization interface [polypeptide binding]; other site 693970001305 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693970001306 DNA binding site [nucleotide binding] 693970001307 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 693970001308 dimer interface [polypeptide binding]; other site 693970001309 Cation efflux family; Region: Cation_efflux; cl00316 693970001310 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 693970001311 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 693970001312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970001313 active site 693970001314 phosphorylation site [posttranslational modification] 693970001315 intermolecular recognition site; other site 693970001316 dimerization interface [polypeptide binding]; other site 693970001317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970001318 Walker A motif; other site 693970001319 ATP binding site [chemical binding]; other site 693970001320 Walker B motif; other site 693970001321 arginine finger; other site 693970001322 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693970001323 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 693970001324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970001325 dimer interface [polypeptide binding]; other site 693970001326 phosphorylation site [posttranslational modification] 693970001327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970001328 ATP binding site [chemical binding]; other site 693970001329 Mg2+ binding site [ion binding]; other site 693970001330 G-X-G motif; other site 693970001331 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 693970001332 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693970001333 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 693970001334 putative C-terminal domain interface [polypeptide binding]; other site 693970001335 putative GSH binding site (G-site) [chemical binding]; other site 693970001336 putative dimer interface [polypeptide binding]; other site 693970001337 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 693970001338 N-terminal domain interface [polypeptide binding]; other site 693970001339 dimer interface [polypeptide binding]; other site 693970001340 substrate binding pocket (H-site) [chemical binding]; other site 693970001341 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 693970001342 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 693970001343 potential catalytic triad [active] 693970001344 conserved cys residue [active] 693970001345 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 693970001346 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 693970001347 dimer interface [polypeptide binding]; other site 693970001348 active site 693970001349 metal binding site [ion binding]; metal-binding site 693970001350 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693970001351 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693970001352 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 693970001353 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693970001354 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970001355 dimer interface [polypeptide binding]; other site 693970001356 putative CheW interface [polypeptide binding]; other site 693970001357 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 693970001358 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 693970001359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970001360 S-adenosylmethionine binding site [chemical binding]; other site 693970001361 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 693970001362 substrate binding site [chemical binding]; other site 693970001363 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693970001364 ATP binding site [chemical binding]; other site 693970001365 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970001366 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970001367 metal binding site [ion binding]; metal-binding site 693970001368 active site 693970001369 I-site; other site 693970001370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 693970001371 MOSC domain; Region: MOSC; pfam03473 693970001372 3-alpha domain; Region: 3-alpha; pfam03475 693970001373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 693970001374 Cache domain; Region: Cache_1; pfam02743 693970001375 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970001376 dimerization interface [polypeptide binding]; other site 693970001377 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693970001378 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970001379 dimer interface [polypeptide binding]; other site 693970001380 putative CheW interface [polypeptide binding]; other site 693970001381 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 693970001382 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693970001383 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 693970001384 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 693970001385 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 693970001386 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693970001387 FeS/SAM binding site; other site 693970001388 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 693970001389 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 693970001390 trimer interface [polypeptide binding]; other site 693970001391 dimer interface [polypeptide binding]; other site 693970001392 putative active site [active] 693970001393 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 693970001394 MoaE interaction surface [polypeptide binding]; other site 693970001395 MoeB interaction surface [polypeptide binding]; other site 693970001396 thiocarboxylated glycine; other site 693970001397 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 693970001398 MoaE homodimer interface [polypeptide binding]; other site 693970001399 MoaD interaction [polypeptide binding]; other site 693970001400 active site residues [active] 693970001401 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 693970001402 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693970001403 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 693970001404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693970001405 dimer interface [polypeptide binding]; other site 693970001406 conserved gate region; other site 693970001407 putative PBP binding loops; other site 693970001408 ABC-ATPase subunit interface; other site 693970001409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970001410 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693970001411 Walker A/P-loop; other site 693970001412 ATP binding site [chemical binding]; other site 693970001413 Q-loop/lid; other site 693970001414 ABC transporter signature motif; other site 693970001415 Walker B; other site 693970001416 D-loop; other site 693970001417 H-loop/switch region; other site 693970001418 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693970001419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970001420 active site 693970001421 phosphorylation site [posttranslational modification] 693970001422 intermolecular recognition site; other site 693970001423 dimerization interface [polypeptide binding]; other site 693970001424 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693970001425 DNA binding site [nucleotide binding] 693970001426 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693970001427 HAMP domain; Region: HAMP; pfam00672 693970001428 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970001429 dimer interface [polypeptide binding]; other site 693970001430 phosphorylation site [posttranslational modification] 693970001431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970001432 ATP binding site [chemical binding]; other site 693970001433 Mg2+ binding site [ion binding]; other site 693970001434 G-X-G motif; other site 693970001435 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693970001436 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693970001437 active site 693970001438 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970001439 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970001440 metal binding site [ion binding]; metal-binding site 693970001441 active site 693970001442 I-site; other site 693970001443 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 693970001444 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693970001445 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693970001446 N-terminal plug; other site 693970001447 ligand-binding site [chemical binding]; other site 693970001448 Protein of unknown function (DUF2986); Region: DUF2986; pfam11661 693970001449 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693970001450 Peptidase family M23; Region: Peptidase_M23; pfam01551 693970001451 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 693970001452 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 693970001453 Domain of unknown function (DUF1864); Region: DUF1864; pfam08933 693970001454 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 693970001455 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 693970001456 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693970001457 catalytic residue [active] 693970001458 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693970001459 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 693970001460 glutamine synthetase; Provisional; Region: glnA; PRK09469 693970001461 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 693970001462 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693970001463 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 693970001464 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 693970001465 G1 box; other site 693970001466 putative GEF interaction site [polypeptide binding]; other site 693970001467 GTP/Mg2+ binding site [chemical binding]; other site 693970001468 Switch I region; other site 693970001469 G2 box; other site 693970001470 G3 box; other site 693970001471 Switch II region; other site 693970001472 G4 box; other site 693970001473 G5 box; other site 693970001474 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 693970001475 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 693970001476 SnoaL-like domain; Region: SnoaL_3; pfam13474 693970001477 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970001478 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970001479 metal binding site [ion binding]; metal-binding site 693970001480 active site 693970001481 I-site; other site 693970001482 Sulfatase; Region: Sulfatase; cl17466 693970001483 4Fe-4S binding domain; Region: Fer4_5; pfam12801 693970001484 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 693970001485 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 693970001486 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 693970001487 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 693970001488 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 693970001489 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693970001490 homodimer interface [polypeptide binding]; other site 693970001491 substrate-cofactor binding pocket; other site 693970001492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970001493 catalytic residue [active] 693970001494 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 693970001495 hypothetical protein; Reviewed; Region: PRK01637 693970001496 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693970001497 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 693970001498 putative active site [active] 693970001499 dimerization interface [polypeptide binding]; other site 693970001500 putative tRNAtyr binding site [nucleotide binding]; other site 693970001501 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693970001502 CoenzymeA binding site [chemical binding]; other site 693970001503 subunit interaction site [polypeptide binding]; other site 693970001504 PHB binding site; other site 693970001505 azoreductase; Reviewed; Region: PRK00170 693970001506 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693970001507 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 693970001508 active site residue [active] 693970001509 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693970001510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970001511 non-specific DNA binding site [nucleotide binding]; other site 693970001512 salt bridge; other site 693970001513 sequence-specific DNA binding site [nucleotide binding]; other site 693970001514 Cupin domain; Region: Cupin_2; pfam07883 693970001515 Benzoate membrane transport protein; Region: BenE; pfam03594 693970001516 benzoate transporter; Region: benE; TIGR00843 693970001517 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693970001518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970001519 Coenzyme A binding pocket [chemical binding]; other site 693970001520 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 693970001521 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693970001522 dimer interface [polypeptide binding]; other site 693970001523 active site 693970001524 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 693970001525 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 693970001526 NAD(P) binding site [chemical binding]; other site 693970001527 homotetramer interface [polypeptide binding]; other site 693970001528 homodimer interface [polypeptide binding]; other site 693970001529 active site 693970001530 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 693970001531 putative active site 1 [active] 693970001532 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 693970001533 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693970001534 dimer interface [polypeptide binding]; other site 693970001535 active site 693970001536 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 693970001537 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 693970001538 Predicted exporter [General function prediction only]; Region: COG4258 693970001539 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693970001540 active site 693970001541 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 693970001542 active sites [active] 693970001543 tetramer interface [polypeptide binding]; other site 693970001544 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 693970001545 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 693970001546 Ligand binding site; other site 693970001547 Putative Catalytic site; other site 693970001548 DXD motif; other site 693970001549 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 693970001550 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 693970001551 putative acyl-acceptor binding pocket; other site 693970001552 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 693970001553 active site 2 [active] 693970001554 dimer interface [polypeptide binding]; other site 693970001555 active site 1 [active] 693970001556 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 693970001557 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693970001558 acyl-activating enzyme (AAE) consensus motif; other site 693970001559 AMP binding site [chemical binding]; other site 693970001560 active site 693970001561 CoA binding site [chemical binding]; other site 693970001562 Predicted membrane protein [Function unknown]; Region: COG4648 693970001563 acyl carrier protein; Provisional; Region: PRK05350 693970001564 Phosphopantetheine attachment site; Region: PP-binding; cl09936 693970001565 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 693970001566 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 693970001567 putative acyl-acceptor binding pocket; other site 693970001568 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 693970001569 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 693970001570 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 693970001571 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 693970001572 generic binding surface II; other site 693970001573 ssDNA binding site; other site 693970001574 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693970001575 ATP binding site [chemical binding]; other site 693970001576 putative Mg++ binding site [ion binding]; other site 693970001577 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970001578 nucleotide binding region [chemical binding]; other site 693970001579 ATP-binding site [chemical binding]; other site 693970001580 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693970001581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970001582 active site 693970001583 phosphorylation site [posttranslational modification] 693970001584 intermolecular recognition site; other site 693970001585 dimerization interface [polypeptide binding]; other site 693970001586 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693970001587 DNA binding residues [nucleotide binding] 693970001588 dimerization interface [polypeptide binding]; other site 693970001589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 693970001590 Histidine kinase; Region: HisKA_3; pfam07730 693970001591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970001592 ATP binding site [chemical binding]; other site 693970001593 Mg2+ binding site [ion binding]; other site 693970001594 G-X-G motif; other site 693970001595 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 693970001596 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 693970001597 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 693970001598 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 693970001599 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 693970001600 acyl-activating enzyme (AAE) consensus motif; other site 693970001601 putative AMP binding site [chemical binding]; other site 693970001602 putative active site [active] 693970001603 putative CoA binding site [chemical binding]; other site 693970001604 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693970001605 homotrimer interaction site [polypeptide binding]; other site 693970001606 putative active site [active] 693970001607 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 693970001608 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693970001609 Zn2+ binding site [ion binding]; other site 693970001610 Mg2+ binding site [ion binding]; other site 693970001611 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 693970001612 synthetase active site [active] 693970001613 NTP binding site [chemical binding]; other site 693970001614 metal binding site [ion binding]; metal-binding site 693970001615 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 693970001616 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 693970001617 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 693970001618 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 693970001619 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 693970001620 catalytic site [active] 693970001621 G-X2-G-X-G-K; other site 693970001622 ribonuclease E; Reviewed; Region: rne; PRK10811 693970001623 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693970001624 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 693970001625 active site 693970001626 Phosphotransferase enzyme family; Region: APH; pfam01636 693970001627 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 693970001628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970001629 putative substrate translocation pore; other site 693970001630 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693970001631 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 693970001632 Fic family protein [Function unknown]; Region: COG3177 693970001633 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 693970001634 Fic/DOC family; Region: Fic; pfam02661 693970001635 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 693970001636 PLD-like domain; Region: PLDc_2; pfam13091 693970001637 putative homodimer interface [polypeptide binding]; other site 693970001638 putative active site [active] 693970001639 catalytic site [active] 693970001640 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 693970001641 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693970001642 ATP binding site [chemical binding]; other site 693970001643 putative Mg++ binding site [ion binding]; other site 693970001644 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970001645 nucleotide binding region [chemical binding]; other site 693970001646 ATP-binding site [chemical binding]; other site 693970001647 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 693970001648 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970001649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970001650 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693970001651 putative effector binding pocket; other site 693970001652 dimerization interface [polypeptide binding]; other site 693970001653 dUMP phosphatase; Provisional; Region: PRK09449 693970001654 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693970001655 motif II; other site 693970001656 ERCC4 domain; Region: ERCC4; smart00891 693970001657 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693970001658 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970001659 non-specific DNA binding site [nucleotide binding]; other site 693970001660 salt bridge; other site 693970001661 sequence-specific DNA binding site [nucleotide binding]; other site 693970001662 hypothetical protein; Provisional; Region: PRK11820 693970001663 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 693970001664 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 693970001665 ribonuclease PH; Reviewed; Region: rph; PRK00173 693970001666 Ribonuclease PH; Region: RNase_PH_bact; cd11362 693970001667 hexamer interface [polypeptide binding]; other site 693970001668 active site 693970001669 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693970001670 active site 693970001671 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 693970001672 GTP cyclohydrolase I; Provisional; Region: PLN03044 693970001673 active site 693970001674 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 693970001675 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693970001676 division inhibitor protein; Provisional; Region: slmA; PRK09480 693970001677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693970001678 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 693970001679 trimer interface [polypeptide binding]; other site 693970001680 active site 693970001681 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 693970001682 Flavoprotein; Region: Flavoprotein; pfam02441 693970001683 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 693970001684 hypothetical protein; Reviewed; Region: PRK00024 693970001685 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 693970001686 MPN+ (JAMM) motif; other site 693970001687 Zinc-binding site [ion binding]; other site 693970001688 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 693970001689 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 693970001690 N-acetylglutamate synthase; Validated; Region: PRK05279 693970001691 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 693970001692 putative feedback inhibition sensing region; other site 693970001693 putative nucleotide binding site [chemical binding]; other site 693970001694 putative substrate binding site [chemical binding]; other site 693970001695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970001696 Coenzyme A binding pocket [chemical binding]; other site 693970001697 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 693970001698 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693970001699 CoenzymeA binding site [chemical binding]; other site 693970001700 subunit interaction site [polypeptide binding]; other site 693970001701 PHB binding site; other site 693970001702 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 693970001703 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693970001704 ATP binding site [chemical binding]; other site 693970001705 putative Mg++ binding site [ion binding]; other site 693970001706 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970001707 nucleotide binding region [chemical binding]; other site 693970001708 ATP-binding site [chemical binding]; other site 693970001709 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 693970001710 HRDC domain; Region: HRDC; pfam00570 693970001711 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970001712 I-site; other site 693970001713 active site 693970001714 metal binding site [ion binding]; metal-binding site 693970001715 2-isopropylmalate synthase; Validated; Region: PRK00915 693970001716 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 693970001717 active site 693970001718 catalytic residues [active] 693970001719 metal binding site [ion binding]; metal-binding site 693970001720 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 693970001721 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 693970001722 tartrate dehydrogenase; Region: TTC; TIGR02089 693970001723 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 693970001724 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 693970001725 substrate binding site [chemical binding]; other site 693970001726 ligand binding site [chemical binding]; other site 693970001727 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 693970001728 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 693970001729 substrate binding site [chemical binding]; other site 693970001730 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 693970001731 glycerol kinase; Provisional; Region: glpK; PRK00047 693970001732 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 693970001733 N- and C-terminal domain interface [polypeptide binding]; other site 693970001734 active site 693970001735 MgATP binding site [chemical binding]; other site 693970001736 catalytic site [active] 693970001737 metal binding site [ion binding]; metal-binding site 693970001738 glycerol binding site [chemical binding]; other site 693970001739 homotetramer interface [polypeptide binding]; other site 693970001740 homodimer interface [polypeptide binding]; other site 693970001741 FBP binding site [chemical binding]; other site 693970001742 protein IIAGlc interface [polypeptide binding]; other site 693970001743 cell division protein MraZ; Reviewed; Region: PRK00326 693970001744 MraZ protein; Region: MraZ; pfam02381 693970001745 MraZ protein; Region: MraZ; pfam02381 693970001746 MraW methylase family; Region: Methyltransf_5; pfam01795 693970001747 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 693970001748 Cell division protein FtsL; Region: FtsL; pfam04999 693970001749 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 693970001750 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 693970001751 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 693970001752 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 693970001753 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693970001754 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693970001755 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693970001756 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 693970001757 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693970001758 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693970001759 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693970001760 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 693970001761 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 693970001762 Mg++ binding site [ion binding]; other site 693970001763 putative catalytic motif [active] 693970001764 putative substrate binding site [chemical binding]; other site 693970001765 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 693970001766 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693970001767 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693970001768 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 693970001769 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 693970001770 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 693970001771 active site 693970001772 homodimer interface [polypeptide binding]; other site 693970001773 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 693970001774 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693970001775 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693970001776 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693970001777 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 693970001778 Cell division protein FtsQ; Region: FtsQ; pfam03799 693970001779 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 693970001780 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693970001781 nucleotide binding site [chemical binding]; other site 693970001782 Cell division protein FtsA; Region: FtsA; pfam14450 693970001783 cell division protein FtsZ; Validated; Region: PRK09330 693970001784 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 693970001785 nucleotide binding site [chemical binding]; other site 693970001786 SulA interaction site; other site 693970001787 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 693970001788 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 693970001789 Protein of unknown function (DUF721); Region: DUF721; cl02324 693970001790 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693970001791 Peptidase family M23; Region: Peptidase_M23; pfam01551 693970001792 preprotein translocase subunit SecA; Reviewed; Region: PRK13107 693970001793 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 693970001794 SEC-C motif; Region: SEC-C; pfam02810 693970001795 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 693970001796 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 693970001797 substrate binding site [chemical binding]; other site 693970001798 active site 693970001799 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 693970001800 short chain dehydrogenase; Provisional; Region: PRK06181 693970001801 NADP binding site [chemical binding]; other site 693970001802 homodimer interface [polypeptide binding]; other site 693970001803 substrate binding site [chemical binding]; other site 693970001804 active site 693970001805 Peptidase M60-like family; Region: M60-like; pfam13402 693970001806 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 693970001807 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 693970001808 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 693970001809 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 693970001810 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 693970001811 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 693970001812 purine monophosphate binding site [chemical binding]; other site 693970001813 dimer interface [polypeptide binding]; other site 693970001814 putative catalytic residues [active] 693970001815 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 693970001816 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 693970001817 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 693970001818 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 693970001819 DNA binding residues [nucleotide binding] 693970001820 dimer interface [polypeptide binding]; other site 693970001821 metal binding site [ion binding]; metal-binding site 693970001822 Predicted permease; Region: DUF318; cl17795 693970001823 Predicted permease; Region: DUF318; cl17795 693970001824 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 693970001825 SPFH domain / Band 7 family; Region: Band_7; pfam01145 693970001826 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 693970001827 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693970001828 RNA binding surface [nucleotide binding]; other site 693970001829 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 693970001830 active site 693970001831 uracil binding [chemical binding]; other site 693970001832 putative MFS family transporter protein; Provisional; Region: PRK03633 693970001833 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 693970001834 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 693970001835 transmembrane helices; other site 693970001836 thioredoxin 2; Provisional; Region: PRK10996 693970001837 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 693970001838 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693970001839 catalytic residues [active] 693970001840 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693970001841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970001842 putative active site [active] 693970001843 PAS fold; Region: PAS_3; pfam08447 693970001844 heme pocket [chemical binding]; other site 693970001845 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970001846 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970001847 metal binding site [ion binding]; metal-binding site 693970001848 active site 693970001849 I-site; other site 693970001850 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 693970001851 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 693970001852 DctM-like transporters; Region: DctM; pfam06808 693970001853 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 693970001854 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 693970001855 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 693970001856 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 693970001857 conjugal transfer protein TraV; Provisional; Region: PRK13733 693970001858 Poxvirus P35 protein; Region: Pox_P35; pfam03213 693970001859 Predicted metalloprotease [General function prediction only]; Region: COG2321 693970001860 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 693970001861 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 693970001862 nudix motif; other site 693970001863 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693970001864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970001865 S-adenosylmethionine binding site [chemical binding]; other site 693970001866 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 693970001867 Part of AAA domain; Region: AAA_19; pfam13245 693970001868 Family description; Region: UvrD_C_2; pfam13538 693970001869 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 693970001870 UbiA prenyltransferase family; Region: UbiA; pfam01040 693970001871 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 693970001872 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693970001873 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 693970001874 putative dimer interface [polypeptide binding]; other site 693970001875 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693970001876 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 693970001877 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 693970001878 FMN binding site [chemical binding]; other site 693970001879 substrate binding site [chemical binding]; other site 693970001880 putative catalytic residue [active] 693970001881 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 693970001882 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693970001883 catalytic residues [active] 693970001884 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693970001885 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693970001886 catalytic residues [active] 693970001887 Domain of unknown function DUF20; Region: UPF0118; pfam01594 693970001888 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 693970001889 Pathogenicity locus; Region: Cdd1; pfam11731 693970001890 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 693970001891 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 693970001892 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 693970001893 active site 693970001894 Zn binding site [ion binding]; other site 693970001895 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 693970001896 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 693970001897 Transposase; Region: HTH_Tnp_1; cl17663 693970001898 Winged helix-turn helix; Region: HTH_29; pfam13551 693970001899 Homeodomain-like domain; Region: HTH_32; pfam13565 693970001900 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970001901 Integrase core domain; Region: rve; pfam00665 693970001902 Integrase core domain; Region: rve_3; pfam13683 693970001903 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 693970001904 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693970001905 FMN reductase; Validated; Region: fre; PRK08051 693970001906 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 693970001907 FAD binding pocket [chemical binding]; other site 693970001908 FAD binding motif [chemical binding]; other site 693970001909 phosphate binding motif [ion binding]; other site 693970001910 beta-alpha-beta structure motif; other site 693970001911 NAD binding pocket [chemical binding]; other site 693970001912 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 693970001913 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693970001914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970001915 putative substrate translocation pore; other site 693970001916 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693970001917 NAD(P) binding site [chemical binding]; other site 693970001918 active site 693970001919 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 693970001920 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693970001921 carboxyltransferase (CT) interaction site; other site 693970001922 biotinylation site [posttranslational modification]; other site 693970001923 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 693970001924 Dehydroquinase class II; Region: DHquinase_II; pfam01220 693970001925 active site 693970001926 trimer interface [polypeptide binding]; other site 693970001927 dimer interface [polypeptide binding]; other site 693970001928 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 693970001929 hypothetical protein; Provisional; Region: PRK09256 693970001930 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 693970001931 Protein of unknown function (DUF3012); Region: DUF3012; pfam11216 693970001932 Outer membrane efflux protein; Region: OEP; pfam02321 693970001933 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693970001934 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693970001935 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970001936 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 693970001937 Protein export membrane protein; Region: SecD_SecF; cl14618 693970001938 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 693970001939 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 693970001940 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 693970001941 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970001942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970001943 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693970001944 putative effector binding pocket; other site 693970001945 dimerization interface [polypeptide binding]; other site 693970001946 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 693970001947 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693970001948 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970001949 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 693970001950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970001951 putative substrate translocation pore; other site 693970001952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970001953 putative substrate translocation pore; other site 693970001954 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693970001955 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970001956 Coenzyme A binding pocket [chemical binding]; other site 693970001957 Uncharacterized conserved protein [Function unknown]; Region: COG1359 693970001958 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693970001959 Radical SAM superfamily; Region: Radical_SAM; pfam04055 693970001960 FeS/SAM binding site; other site 693970001961 Isochorismatase family; Region: Isochorismatase; pfam00857 693970001962 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 693970001963 catalytic triad [active] 693970001964 conserved cis-peptide bond; other site 693970001965 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 693970001966 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 693970001967 conserved cys residue [active] 693970001968 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693970001969 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693970001970 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 693970001971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970001972 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693970001973 dimerization interface [polypeptide binding]; other site 693970001974 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693970001975 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693970001976 dimerization interface [polypeptide binding]; other site 693970001977 putative DNA binding site [nucleotide binding]; other site 693970001978 putative Zn2+ binding site [ion binding]; other site 693970001979 Predicted permeases [General function prediction only]; Region: COG0701 693970001980 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693970001981 catalytic residues [active] 693970001982 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 693970001983 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 693970001984 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 693970001985 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693970001986 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 693970001987 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693970001988 amino acid carrier protein; Region: agcS; TIGR00835 693970001989 conserved hypothetical protein; Region: QEGLA; TIGR02421 693970001990 CHASE domain; Region: CHASE; pfam03924 693970001991 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 693970001992 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970001993 putative active site [active] 693970001994 heme pocket [chemical binding]; other site 693970001995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970001996 dimer interface [polypeptide binding]; other site 693970001997 phosphorylation site [posttranslational modification] 693970001998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970001999 ATP binding site [chemical binding]; other site 693970002000 Mg2+ binding site [ion binding]; other site 693970002001 G-X-G motif; other site 693970002002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970002003 active site 693970002004 phosphorylation site [posttranslational modification] 693970002005 intermolecular recognition site; other site 693970002006 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693970002007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970002008 active site 693970002009 phosphorylation site [posttranslational modification] 693970002010 intermolecular recognition site; other site 693970002011 dimerization interface [polypeptide binding]; other site 693970002012 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970002013 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970002014 metal binding site [ion binding]; metal-binding site 693970002015 active site 693970002016 I-site; other site 693970002017 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970002018 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 693970002019 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693970002020 conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001 693970002021 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693970002022 IHF dimer interface [polypeptide binding]; other site 693970002023 IHF - DNA interface [nucleotide binding]; other site 693970002024 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693970002025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970002026 active site 693970002027 phosphorylation site [posttranslational modification] 693970002028 intermolecular recognition site; other site 693970002029 dimerization interface [polypeptide binding]; other site 693970002030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970002031 Response regulator receiver domain; Region: Response_reg; pfam00072 693970002032 active site 693970002033 phosphorylation site [posttranslational modification] 693970002034 intermolecular recognition site; other site 693970002035 dimerization interface [polypeptide binding]; other site 693970002036 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 693970002037 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 693970002038 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970002039 FOG: CBS domain [General function prediction only]; Region: COG0517 693970002040 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 693970002041 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970002042 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970002043 metal binding site [ion binding]; metal-binding site 693970002044 active site 693970002045 I-site; other site 693970002046 TraB family; Region: TraB; pfam01963 693970002047 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 693970002048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970002049 S-adenosylmethionine binding site [chemical binding]; other site 693970002050 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 693970002051 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 693970002052 active site 2 [active] 693970002053 active site 1 [active] 693970002054 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693970002055 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693970002056 active site 693970002057 catalytic tetrad [active] 693970002058 formate--tetrahydrofolate ligase; Provisional; Region: PRK13506 693970002059 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 693970002060 Potassium binding sites [ion binding]; other site 693970002061 Cesium cation binding sites [ion binding]; other site 693970002062 Periplasmic binding protein TroA_c. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_c; cd01145 693970002063 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 693970002064 putative ligand binding site [chemical binding]; other site 693970002065 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 693970002066 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 693970002067 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 693970002068 putative acyl-acceptor binding pocket; other site 693970002069 RNase E inhibitor protein; Provisional; Region: PRK11191 693970002070 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 693970002071 PAS domain; Region: PAS_9; pfam13426 693970002072 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970002073 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970002074 metal binding site [ion binding]; metal-binding site 693970002075 active site 693970002076 I-site; other site 693970002077 Response regulator receiver domain; Region: Response_reg; pfam00072 693970002078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970002079 active site 693970002080 phosphorylation site [posttranslational modification] 693970002081 intermolecular recognition site; other site 693970002082 dimerization interface [polypeptide binding]; other site 693970002083 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 693970002084 enoyl-CoA hydratase; Provisional; Region: PRK07509 693970002085 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693970002086 substrate binding site [chemical binding]; other site 693970002087 oxyanion hole (OAH) forming residues; other site 693970002088 trimer interface [polypeptide binding]; other site 693970002089 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 693970002090 ATP-dependent helicase HepA; Validated; Region: PRK04914 693970002091 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693970002092 ATP binding site [chemical binding]; other site 693970002093 putative Mg++ binding site [ion binding]; other site 693970002094 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970002095 nucleotide binding region [chemical binding]; other site 693970002096 ATP-binding site [chemical binding]; other site 693970002097 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 693970002098 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 693970002099 putative active site [active] 693970002100 PhoH-like protein; Region: PhoH; pfam02562 693970002101 Cache domain; Region: Cache_1; pfam02743 693970002102 PAS fold; Region: PAS_4; pfam08448 693970002103 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970002104 putative active site [active] 693970002105 heme pocket [chemical binding]; other site 693970002106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970002107 PAS fold; Region: PAS_3; pfam08447 693970002108 putative active site [active] 693970002109 heme pocket [chemical binding]; other site 693970002110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970002111 dimer interface [polypeptide binding]; other site 693970002112 phosphorylation site [posttranslational modification] 693970002113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970002114 ATP binding site [chemical binding]; other site 693970002115 Mg2+ binding site [ion binding]; other site 693970002116 G-X-G motif; other site 693970002117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970002118 Response regulator receiver domain; Region: Response_reg; pfam00072 693970002119 active site 693970002120 phosphorylation site [posttranslational modification] 693970002121 intermolecular recognition site; other site 693970002122 dimerization interface [polypeptide binding]; other site 693970002123 Response regulator receiver domain; Region: Response_reg; pfam00072 693970002124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970002125 active site 693970002126 phosphorylation site [posttranslational modification] 693970002127 intermolecular recognition site; other site 693970002128 dimerization interface [polypeptide binding]; other site 693970002129 Protein kinase domain; Region: Pkinase; pfam00069 693970002130 Catalytic domain of Protein Kinases; Region: PKc; cd00180 693970002131 active site 693970002132 ATP binding site [chemical binding]; other site 693970002133 substrate binding site [chemical binding]; other site 693970002134 activation loop (A-loop); other site 693970002135 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 693970002136 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 693970002137 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970002138 PAS fold; Region: PAS_3; pfam08447 693970002139 putative active site [active] 693970002140 heme pocket [chemical binding]; other site 693970002141 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693970002142 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970002143 dimer interface [polypeptide binding]; other site 693970002144 putative CheW interface [polypeptide binding]; other site 693970002145 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 693970002146 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 693970002147 NAD binding site [chemical binding]; other site 693970002148 ligand binding site [chemical binding]; other site 693970002149 catalytic site [active] 693970002150 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 693970002151 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 693970002152 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 693970002153 active site 693970002154 catalytic site [active] 693970002155 putative mechanosensitive channel protein; Provisional; Region: PRK10929 693970002156 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 693970002157 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693970002158 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693970002159 EamA-like transporter family; Region: EamA; pfam00892 693970002160 EamA-like transporter family; Region: EamA; pfam00892 693970002161 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 693970002162 GTPase RsgA; Reviewed; Region: PRK12288 693970002163 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 693970002164 RNA binding site [nucleotide binding]; other site 693970002165 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 693970002166 GTPase/Zn-binding domain interface [polypeptide binding]; other site 693970002167 GTP/Mg2+ binding site [chemical binding]; other site 693970002168 G4 box; other site 693970002169 G5 box; other site 693970002170 G1 box; other site 693970002171 Switch I region; other site 693970002172 G2 box; other site 693970002173 G3 box; other site 693970002174 Switch II region; other site 693970002175 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 693970002176 catalytic site [active] 693970002177 putative active site [active] 693970002178 putative substrate binding site [chemical binding]; other site 693970002179 dimer interface [polypeptide binding]; other site 693970002180 putative carbohydrate kinase; Provisional; Region: PRK10565 693970002181 Uncharacterized conserved protein [Function unknown]; Region: COG0062 693970002182 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 693970002183 putative substrate binding site [chemical binding]; other site 693970002184 putative ATP binding site [chemical binding]; other site 693970002185 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 693970002186 AMIN domain; Region: AMIN; pfam11741 693970002187 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 693970002188 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 693970002189 active site 693970002190 metal binding site [ion binding]; metal-binding site 693970002191 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 693970002192 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693970002193 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 693970002194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970002195 ATP binding site [chemical binding]; other site 693970002196 Mg2+ binding site [ion binding]; other site 693970002197 G-X-G motif; other site 693970002198 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 693970002199 ATP binding site [chemical binding]; other site 693970002200 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 693970002201 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 693970002202 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 693970002203 active site 693970002204 bacterial Hfq-like; Region: Hfq; cd01716 693970002205 hexamer interface [polypeptide binding]; other site 693970002206 Sm1 motif; other site 693970002207 RNA binding site [nucleotide binding]; other site 693970002208 Sm2 motif; other site 693970002209 GTPase HflX; Provisional; Region: PRK11058 693970002210 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 693970002211 HflX GTPase family; Region: HflX; cd01878 693970002212 G1 box; other site 693970002213 GTP/Mg2+ binding site [chemical binding]; other site 693970002214 Switch I region; other site 693970002215 G2 box; other site 693970002216 G3 box; other site 693970002217 Switch II region; other site 693970002218 G4 box; other site 693970002219 G5 box; other site 693970002220 FtsH protease regulator HflK; Provisional; Region: PRK10930 693970002221 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 693970002222 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 693970002223 FtsH protease regulator HflC; Provisional; Region: PRK11029 693970002224 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 693970002225 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 693970002226 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 693970002227 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 693970002228 [2Fe-2S] cluster binding site [ion binding]; other site 693970002229 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 693970002230 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 693970002231 Qi binding site; other site 693970002232 intrachain domain interface; other site 693970002233 interchain domain interface [polypeptide binding]; other site 693970002234 heme bH binding site [chemical binding]; other site 693970002235 heme bL binding site [chemical binding]; other site 693970002236 Qo binding site; other site 693970002237 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 693970002238 interchain domain interface [polypeptide binding]; other site 693970002239 intrachain domain interface; other site 693970002240 Qi binding site; other site 693970002241 Qo binding site; other site 693970002242 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 693970002243 stringent starvation protein A; Provisional; Region: sspA; PRK09481 693970002244 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 693970002245 C-terminal domain interface [polypeptide binding]; other site 693970002246 putative GSH binding site (G-site) [chemical binding]; other site 693970002247 dimer interface [polypeptide binding]; other site 693970002248 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 693970002249 dimer interface [polypeptide binding]; other site 693970002250 N-terminal domain interface [polypeptide binding]; other site 693970002251 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 693970002252 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 693970002253 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 693970002254 glutamine binding [chemical binding]; other site 693970002255 catalytic triad [active] 693970002256 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 693970002257 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693970002258 HDOD domain; Region: HDOD; pfam08668 693970002259 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 693970002260 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 693970002261 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 693970002262 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693970002263 inhibitor-cofactor binding pocket; inhibition site 693970002264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970002265 catalytic residue [active] 693970002266 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 693970002267 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 693970002268 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 693970002269 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 693970002270 NAD(P) binding site [chemical binding]; other site 693970002271 catalytic residues [active] 693970002272 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 693970002273 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693970002274 HAMP domain; Region: HAMP; pfam00672 693970002275 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 693970002276 dimer interface [polypeptide binding]; other site 693970002277 phosphorylation site [posttranslational modification] 693970002278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970002279 ATP binding site [chemical binding]; other site 693970002280 Mg2+ binding site [ion binding]; other site 693970002281 G-X-G motif; other site 693970002282 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693970002283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970002284 active site 693970002285 phosphorylation site [posttranslational modification] 693970002286 intermolecular recognition site; other site 693970002287 dimerization interface [polypeptide binding]; other site 693970002288 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693970002289 DNA binding site [nucleotide binding] 693970002290 Predicted membrane protein [Function unknown]; Region: COG3212 693970002291 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 693970002292 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693970002293 ligand binding site [chemical binding]; other site 693970002294 flexible hinge region; other site 693970002295 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 693970002296 putative switch regulator; other site 693970002297 non-specific DNA interactions [nucleotide binding]; other site 693970002298 DNA binding site [nucleotide binding] 693970002299 sequence specific DNA binding site [nucleotide binding]; other site 693970002300 putative cAMP binding site [chemical binding]; other site 693970002301 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693970002302 Sel1-like repeats; Region: SEL1; smart00671 693970002303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970002304 TPR motif; other site 693970002305 binding surface 693970002306 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 693970002307 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 693970002308 GAF domain; Region: GAF; cl17456 693970002309 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970002310 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970002311 metal binding site [ion binding]; metal-binding site 693970002312 active site 693970002313 I-site; other site 693970002314 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970002315 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 693970002316 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693970002317 ATP binding site [chemical binding]; other site 693970002318 putative Mg++ binding site [ion binding]; other site 693970002319 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970002320 nucleotide binding region [chemical binding]; other site 693970002321 ATP-binding site [chemical binding]; other site 693970002322 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 693970002323 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 693970002324 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 693970002325 Transglycosylase; Region: Transgly; pfam00912 693970002326 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 693970002327 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 693970002328 Protein of unknown function (DUF3581); Region: DUF3581; pfam12119 693970002329 PAS domain; Region: PAS_9; pfam13426 693970002330 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970002331 putative active site [active] 693970002332 heme pocket [chemical binding]; other site 693970002333 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970002334 PAS domain; Region: PAS_9; pfam13426 693970002335 putative active site [active] 693970002336 heme pocket [chemical binding]; other site 693970002337 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970002338 dimer interface [polypeptide binding]; other site 693970002339 putative CheW interface [polypeptide binding]; other site 693970002340 tetrathionate reductase subunit A; Provisional; Region: PRK14991 693970002341 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693970002342 molybdopterin cofactor binding site; other site 693970002343 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693970002344 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 693970002345 putative molybdopterin cofactor binding site; other site 693970002346 tetrathionate reductase subunit C; Provisional; Region: PRK14992 693970002347 tetrathionate reductase subunit B; Provisional; Region: PRK14993 693970002348 4Fe-4S binding domain; Region: Fer4; pfam00037 693970002349 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 693970002350 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 693970002351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970002352 dimer interface [polypeptide binding]; other site 693970002353 phosphorylation site [posttranslational modification] 693970002354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970002355 ATP binding site [chemical binding]; other site 693970002356 Mg2+ binding site [ion binding]; other site 693970002357 G-X-G motif; other site 693970002358 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 693970002359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970002360 active site 693970002361 phosphorylation site [posttranslational modification] 693970002362 intermolecular recognition site; other site 693970002363 dimerization interface [polypeptide binding]; other site 693970002364 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693970002365 DNA binding residues [nucleotide binding] 693970002366 dimerization interface [polypeptide binding]; other site 693970002367 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 693970002368 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 693970002369 active site 693970002370 metal binding site [ion binding]; metal-binding site 693970002371 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970002372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970002373 Walker A motif; other site 693970002374 ATP binding site [chemical binding]; other site 693970002375 Walker B motif; other site 693970002376 Integrase core domain; Region: rve; pfam00665 693970002377 hypothetical protein; Provisional; Region: PRK05208 693970002378 fructose-1,6-bisphosphatase family protein; Region: PLN02628 693970002379 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 693970002380 AMP binding site [chemical binding]; other site 693970002381 metal binding site [ion binding]; metal-binding site 693970002382 active site 693970002383 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 693970002384 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 693970002385 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693970002386 two-component response regulator; Provisional; Region: PRK11173 693970002387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970002388 active site 693970002389 phosphorylation site [posttranslational modification] 693970002390 intermolecular recognition site; other site 693970002391 dimerization interface [polypeptide binding]; other site 693970002392 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693970002393 DNA binding site [nucleotide binding] 693970002394 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 693970002395 aspartate kinase III; Validated; Region: PRK09084 693970002396 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 693970002397 nucleotide binding site [chemical binding]; other site 693970002398 substrate binding site [chemical binding]; other site 693970002399 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 693970002400 dimer interface [polypeptide binding]; other site 693970002401 allosteric regulatory binding pocket; other site 693970002402 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 693970002403 dimer interface [polypeptide binding]; other site 693970002404 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 693970002405 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 693970002406 active site 693970002407 Zn binding site [ion binding]; other site 693970002408 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 693970002409 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 693970002410 Cl binding site [ion binding]; other site 693970002411 oligomer interface [polypeptide binding]; other site 693970002412 Uncharacterized protein family (UPF0231); Region: UPF0231; pfam06062 693970002413 transcriptional regulator NarL; Provisional; Region: PRK10651 693970002414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970002415 active site 693970002416 phosphorylation site [posttranslational modification] 693970002417 intermolecular recognition site; other site 693970002418 dimerization interface [polypeptide binding]; other site 693970002419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693970002420 DNA binding residues [nucleotide binding] 693970002421 dimerization interface [polypeptide binding]; other site 693970002422 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 693970002423 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 693970002424 HAMP domain; Region: HAMP; pfam00672 693970002425 Histidine kinase; Region: HisKA_3; pfam07730 693970002426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970002427 ATP binding site [chemical binding]; other site 693970002428 Mg2+ binding site [ion binding]; other site 693970002429 G-X-G motif; other site 693970002430 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 693970002431 Isochorismatase family; Region: Isochorismatase; pfam00857 693970002432 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 693970002433 catalytic triad [active] 693970002434 dimer interface [polypeptide binding]; other site 693970002435 conserved cis-peptide bond; other site 693970002436 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 693970002437 Nitrogen regulatory protein P-II; Region: P-II; smart00938 693970002438 probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644 693970002439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970002440 binding surface 693970002441 TPR motif; other site 693970002442 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693970002443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970002444 binding surface 693970002445 TPR motif; other site 693970002446 TPR repeat; Region: TPR_11; pfam13414 693970002447 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 693970002448 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 693970002449 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693970002450 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 693970002451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970002452 Walker A/P-loop; other site 693970002453 ATP binding site [chemical binding]; other site 693970002454 Q-loop/lid; other site 693970002455 ABC transporter signature motif; other site 693970002456 Walker B; other site 693970002457 D-loop; other site 693970002458 H-loop/switch region; other site 693970002459 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 693970002460 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 693970002461 active site 693970002462 FMN binding site [chemical binding]; other site 693970002463 substrate binding site [chemical binding]; other site 693970002464 3Fe-4S cluster binding site [ion binding]; other site 693970002465 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 693970002466 catalytic core [active] 693970002467 ferredoxin-NADP reductase; Provisional; Region: PRK10926 693970002468 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 693970002469 FAD binding pocket [chemical binding]; other site 693970002470 FAD binding motif [chemical binding]; other site 693970002471 phosphate binding motif [ion binding]; other site 693970002472 beta-alpha-beta structure motif; other site 693970002473 NAD binding pocket [chemical binding]; other site 693970002474 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 693970002475 putative C-terminal domain interface [polypeptide binding]; other site 693970002476 putative GSH binding site (G-site) [chemical binding]; other site 693970002477 putative dimer interface [polypeptide binding]; other site 693970002478 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 693970002479 dimer interface [polypeptide binding]; other site 693970002480 N-terminal domain interface [polypeptide binding]; other site 693970002481 substrate binding pocket (H-site) [chemical binding]; other site 693970002482 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970002483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970002484 Walker A motif; other site 693970002485 ATP binding site [chemical binding]; other site 693970002486 Walker B motif; other site 693970002487 Integrase core domain; Region: rve; pfam00665 693970002488 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 693970002489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693970002490 dimer interface [polypeptide binding]; other site 693970002491 conserved gate region; other site 693970002492 putative PBP binding loops; other site 693970002493 ABC-ATPase subunit interface; other site 693970002494 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 693970002495 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693970002496 Walker A/P-loop; other site 693970002497 ATP binding site [chemical binding]; other site 693970002498 Q-loop/lid; other site 693970002499 ABC transporter signature motif; other site 693970002500 Walker B; other site 693970002501 D-loop; other site 693970002502 H-loop/switch region; other site 693970002503 TOBE domain; Region: TOBE_2; pfam08402 693970002504 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 693970002505 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 693970002506 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 693970002507 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970002508 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970002509 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693970002510 putative effector binding pocket; other site 693970002511 dimerization interface [polypeptide binding]; other site 693970002512 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 693970002513 NADH(P)-binding; Region: NAD_binding_10; pfam13460 693970002514 NAD binding site [chemical binding]; other site 693970002515 substrate binding site [chemical binding]; other site 693970002516 putative active site [active] 693970002517 arginine repressor; Provisional; Region: PRK05066 693970002518 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 693970002519 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 693970002520 malate dehydrogenase; Provisional; Region: PRK05086 693970002521 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 693970002522 NAD binding site [chemical binding]; other site 693970002523 dimerization interface [polypeptide binding]; other site 693970002524 Substrate binding site [chemical binding]; other site 693970002525 Protein of unknown function, DUF393; Region: DUF393; pfam04134 693970002526 dihydromonapterin reductase; Provisional; Region: PRK06483 693970002527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693970002528 NAD(P) binding site [chemical binding]; other site 693970002529 active site 693970002530 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 693970002531 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 693970002532 Cell division protein ZapA; Region: ZapA; pfam05164 693970002533 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 693970002534 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 693970002535 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 693970002536 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 693970002537 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 693970002538 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 693970002539 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 693970002540 glycine cleavage system protein H; Provisional; Region: PRK13380 693970002541 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 693970002542 lipoyl attachment site [posttranslational modification]; other site 693970002543 glycine dehydrogenase; Provisional; Region: PRK05367 693970002544 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 693970002545 tetramer interface [polypeptide binding]; other site 693970002546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970002547 catalytic residue [active] 693970002548 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 693970002549 tetramer interface [polypeptide binding]; other site 693970002550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970002551 catalytic residue [active] 693970002552 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693970002553 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693970002554 Uncharacterized conserved protein [Function unknown]; Region: COG0398 693970002555 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 693970002556 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 693970002557 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 693970002558 NADH(P)-binding; Region: NAD_binding_10; pfam13460 693970002559 NAD(P) binding site [chemical binding]; other site 693970002560 putative active site [active] 693970002561 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 693970002562 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 693970002563 NAD binding site [chemical binding]; other site 693970002564 active site 693970002565 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 693970002566 putative hydrophobic ligand binding site [chemical binding]; other site 693970002567 protein interface [polypeptide binding]; other site 693970002568 gate; other site 693970002569 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 693970002570 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693970002571 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 693970002572 FMN binding site [chemical binding]; other site 693970002573 active site 693970002574 substrate binding site [chemical binding]; other site 693970002575 catalytic residue [active] 693970002576 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 693970002577 active site 693970002578 dimer interface [polypeptide binding]; other site 693970002579 motif 1; other site 693970002580 motif 2; other site 693970002581 motif 3; other site 693970002582 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 693970002583 anticodon binding site; other site 693970002584 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970002585 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970002586 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 693970002587 putative effector binding pocket; other site 693970002588 putative dimerization interface [polypeptide binding]; other site 693970002589 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693970002590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970002591 putative substrate translocation pore; other site 693970002592 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 693970002593 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 693970002594 putative NAD(P) binding site [chemical binding]; other site 693970002595 putative substrate binding site [chemical binding]; other site 693970002596 catalytic Zn binding site [ion binding]; other site 693970002597 structural Zn binding site [ion binding]; other site 693970002598 dimer interface [polypeptide binding]; other site 693970002599 Uncharacterized conserved protein [Function unknown]; Region: COG4925 693970002600 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 693970002601 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970002602 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970002603 metal binding site [ion binding]; metal-binding site 693970002604 active site 693970002605 I-site; other site 693970002606 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 693970002607 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 693970002608 Ribosome recycling factor; Region: RRF_GI; pfam12614 693970002609 Cache domain; Region: Cache_2; pfam08269 693970002610 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970002611 dimerization interface [polypeptide binding]; other site 693970002612 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693970002613 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970002614 dimer interface [polypeptide binding]; other site 693970002615 putative CheW interface [polypeptide binding]; other site 693970002616 YcaO domain protein; Region: TIGR03549 693970002617 OsmC-like protein; Region: OsmC; pfam02566 693970002618 YcaO-like family; Region: YcaO; pfam02624 693970002619 Mannan-binding protein; Region: MVL; pfam12151 693970002620 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970002621 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970002622 metal binding site [ion binding]; metal-binding site 693970002623 active site 693970002624 I-site; other site 693970002625 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 693970002626 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 693970002627 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 693970002628 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 693970002629 substrate binding pocket [chemical binding]; other site 693970002630 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 693970002631 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693970002632 FOG: CBS domain [General function prediction only]; Region: COG0517 693970002633 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 693970002634 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 693970002635 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 693970002636 putative active site [active] 693970002637 putative metal binding site [ion binding]; other site 693970002638 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 693970002639 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693970002640 active site 693970002641 Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560 693970002642 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 693970002643 putative active site [active] 693970002644 catalytic site [active] 693970002645 putative metal binding site [ion binding]; other site 693970002646 Protein of unknown function (DUF3622); Region: DUF3622; pfam12286 693970002647 Transposase; Region: HTH_Tnp_1; pfam01527 693970002648 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970002649 putative transposase OrfB; Reviewed; Region: PHA02517 693970002650 HTH-like domain; Region: HTH_21; pfam13276 693970002651 Integrase core domain; Region: rve; pfam00665 693970002652 Integrase core domain; Region: rve_2; pfam13333 693970002653 Protein of unknown function (DUF3103); Region: DUF3103; pfam11301 693970002654 azurin; Region: azurin; TIGR02695 693970002655 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693970002656 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 693970002657 substrate binding site [chemical binding]; other site 693970002658 dimer interface [polypeptide binding]; other site 693970002659 ATP binding site [chemical binding]; other site 693970002660 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 693970002661 active site 693970002662 tetramer interface [polypeptide binding]; other site 693970002663 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 693970002664 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 693970002665 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693970002666 N-terminal plug; other site 693970002667 ligand-binding site [chemical binding]; other site 693970002668 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 693970002669 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 693970002670 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693970002671 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 693970002672 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970002673 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970002674 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 693970002675 putative dimerization interface [polypeptide binding]; other site 693970002676 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 693970002677 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 693970002678 THF binding site; other site 693970002679 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 693970002680 substrate binding site [chemical binding]; other site 693970002681 THF binding site; other site 693970002682 zinc-binding site [ion binding]; other site 693970002683 Inclusion body protein; Region: PixA; pfam12306 693970002684 epoxyqueuosine reductase; Region: TIGR00276 693970002685 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 693970002686 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970002687 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970002688 Integrase core domain; Region: rve; pfam00665 693970002689 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 693970002690 active site 693970002691 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 693970002692 Protein of unknown function (DUF3069); Region: DUF3069; pfam11269 693970002693 malate dehydrogenase; Provisional; Region: PRK13529 693970002694 Malic enzyme, N-terminal domain; Region: malic; pfam00390 693970002695 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 693970002696 NAD(P) binding site [chemical binding]; other site 693970002697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 693970002698 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 693970002699 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 693970002700 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 693970002701 Bacterial PH domain; Region: DUF304; pfam03703 693970002702 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693970002703 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693970002704 N-terminal plug; other site 693970002705 ligand-binding site [chemical binding]; other site 693970002706 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693970002707 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 693970002708 putative C-terminal domain interface [polypeptide binding]; other site 693970002709 putative GSH binding site (G-site) [chemical binding]; other site 693970002710 putative dimer interface [polypeptide binding]; other site 693970002711 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 693970002712 dimer interface [polypeptide binding]; other site 693970002713 N-terminal domain interface [polypeptide binding]; other site 693970002714 substrate binding pocket (H-site) [chemical binding]; other site 693970002715 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 693970002716 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 693970002717 synthetase active site [active] 693970002718 NTP binding site [chemical binding]; other site 693970002719 metal binding site [ion binding]; metal-binding site 693970002720 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 693970002721 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 693970002722 active site 693970002723 Zn binding site [ion binding]; other site 693970002724 maltose O-acetyltransferase; Provisional; Region: PRK10092 693970002725 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 693970002726 trimer interface [polypeptide binding]; other site 693970002727 active site 693970002728 substrate binding site [chemical binding]; other site 693970002729 CoA binding site [chemical binding]; other site 693970002730 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693970002731 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 693970002732 RNA binding surface [nucleotide binding]; other site 693970002733 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 693970002734 active site 693970002735 uracil binding [chemical binding]; other site 693970002736 Uncharacterized conserved protein [Function unknown]; Region: COG3595 693970002737 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 693970002738 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 693970002739 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 693970002740 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693970002741 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693970002742 DNA binding residues [nucleotide binding] 693970002743 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693970002744 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970002745 dimerization interface [polypeptide binding]; other site 693970002746 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970002747 dimer interface [polypeptide binding]; other site 693970002748 putative CheW interface [polypeptide binding]; other site 693970002749 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 693970002750 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 693970002751 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693970002752 active site 693970002753 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 693970002754 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 693970002755 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 693970002756 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 693970002757 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 693970002758 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 693970002759 tRNA; other site 693970002760 putative tRNA binding site [nucleotide binding]; other site 693970002761 putative NADP binding site [chemical binding]; other site 693970002762 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 693970002763 peptide chain release factor 1; Validated; Region: prfA; PRK00591 693970002764 This domain is found in peptide chain release factors; Region: PCRF; smart00937 693970002765 RF-1 domain; Region: RF-1; pfam00472 693970002766 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 693970002767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970002768 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 693970002769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970002770 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693970002771 Coenzyme A binding pocket [chemical binding]; other site 693970002772 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 693970002773 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 693970002774 Tetratricopeptide repeat; Region: TPR_9; pfam13371 693970002775 Protein of unknown function (DUF819); Region: DUF819; cl02317 693970002776 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 693970002777 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 693970002778 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 693970002779 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 693970002780 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970002781 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 693970002782 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 693970002783 Nitrogen regulatory protein P-II; Region: P-II; smart00938 693970002784 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 693970002785 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 693970002786 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 693970002787 Predicted integral membrane protein [Function unknown]; Region: COG5652 693970002788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 693970002789 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 693970002790 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 693970002791 muropeptide transporter; Reviewed; Region: ampG; PRK11902 693970002792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970002793 putative substrate translocation pore; other site 693970002794 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 693970002795 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 693970002796 substrate binding site [chemical binding]; other site 693970002797 hypothetical protein; Provisional; Region: PRK11627 693970002798 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 693970002799 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 693970002800 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 693970002801 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 693970002802 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 693970002803 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 693970002804 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693970002805 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693970002806 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693970002807 aromatic acid decarboxylase; Validated; Region: PRK05920 693970002808 Flavoprotein; Region: Flavoprotein; pfam02441 693970002809 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693970002810 active site 693970002811 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693970002812 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693970002813 Walker A/P-loop; other site 693970002814 ATP binding site [chemical binding]; other site 693970002815 Q-loop/lid; other site 693970002816 ABC transporter signature motif; other site 693970002817 Walker B; other site 693970002818 D-loop; other site 693970002819 H-loop/switch region; other site 693970002820 inner membrane transport permease; Provisional; Region: PRK15066 693970002821 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 693970002822 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970002823 Transposase; Region: HTH_Tnp_1; pfam01527 693970002824 putative transposase OrfB; Reviewed; Region: PHA02517 693970002825 HTH-like domain; Region: HTH_21; pfam13276 693970002826 Integrase core domain; Region: rve; pfam00665 693970002827 Integrase core domain; Region: rve_3; pfam13683 693970002828 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 693970002829 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 693970002830 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 693970002831 active site 693970002832 catalytic residues [active] 693970002833 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 693970002834 PA/protease or protease-like domain interface [polypeptide binding]; other site 693970002835 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 693970002836 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 693970002837 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 693970002838 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 693970002839 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693970002840 putative DNA binding site [nucleotide binding]; other site 693970002841 putative Zn2+ binding site [ion binding]; other site 693970002842 AsnC family; Region: AsnC_trans_reg; pfam01037 693970002843 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693970002844 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693970002845 active site 693970002846 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 693970002847 Peptidase family U32; Region: Peptidase_U32; pfam01136 693970002848 Collagenase; Region: DUF3656; pfam12392 693970002849 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 693970002850 pentamer interface [polypeptide binding]; other site 693970002851 dodecaamer interface [polypeptide binding]; other site 693970002852 CAAX protease self-immunity; Region: Abi; pfam02517 693970002853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693970002854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693970002855 Predicted ATPase [General function prediction only]; Region: COG4637 693970002856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970002857 Walker A/P-loop; other site 693970002858 ATP binding site [chemical binding]; other site 693970002859 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693970002860 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 693970002861 active site 693970002862 Fe-S metabolism associated domain; Region: SufE; cl00951 693970002863 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 693970002864 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 693970002865 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693970002866 catalytic residue [active] 693970002867 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970002868 dimerization interface [polypeptide binding]; other site 693970002869 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693970002870 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970002871 dimer interface [polypeptide binding]; other site 693970002872 putative CheW interface [polypeptide binding]; other site 693970002873 Cna protein B-type domain; Region: Cna_B_2; pfam13715 693970002874 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693970002875 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970002876 MltA-interacting protein MipA; Region: MipA; cl01504 693970002877 Protein of unknown function (DUF3019); Region: DUF3019; pfam11456 693970002878 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693970002879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970002880 active site 693970002881 phosphorylation site [posttranslational modification] 693970002882 intermolecular recognition site; other site 693970002883 dimerization interface [polypeptide binding]; other site 693970002884 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693970002885 DNA binding site [nucleotide binding] 693970002886 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693970002887 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970002888 dimerization interface [polypeptide binding]; other site 693970002889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970002890 dimer interface [polypeptide binding]; other site 693970002891 phosphorylation site [posttranslational modification] 693970002892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970002893 ATP binding site [chemical binding]; other site 693970002894 Mg2+ binding site [ion binding]; other site 693970002895 G-X-G motif; other site 693970002896 MltA-interacting protein MipA; Region: MipA; cl01504 693970002897 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693970002898 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693970002899 active site 693970002900 catalytic tetrad [active] 693970002901 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 693970002902 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 693970002903 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 693970002904 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 693970002905 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 693970002906 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 693970002907 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 693970002908 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 693970002909 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693970002910 catalytic loop [active] 693970002911 iron binding site [ion binding]; other site 693970002912 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 693970002913 FAD binding pocket [chemical binding]; other site 693970002914 FAD binding motif [chemical binding]; other site 693970002915 phosphate binding motif [ion binding]; other site 693970002916 beta-alpha-beta structure motif; other site 693970002917 NAD binding pocket [chemical binding]; other site 693970002918 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 693970002919 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 693970002920 active site 693970002921 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 693970002922 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 693970002923 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 693970002924 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 693970002925 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 693970002926 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 693970002927 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693970002928 MarR family; Region: MarR; pfam01047 693970002929 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693970002930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970002931 Coenzyme A binding pocket [chemical binding]; other site 693970002932 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 693970002933 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 693970002934 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 693970002935 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 693970002936 active site 693970002937 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 693970002938 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 693970002939 serine transporter; Region: stp; TIGR00814 693970002940 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693970002941 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970002942 Coenzyme A binding pocket [chemical binding]; other site 693970002943 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 693970002944 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693970002945 META domain; Region: META; pfam03724 693970002946 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970002947 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970002948 metal binding site [ion binding]; metal-binding site 693970002949 active site 693970002950 I-site; other site 693970002951 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970002952 Coenzyme A binding pocket [chemical binding]; other site 693970002953 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 693970002954 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 693970002955 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693970002956 ATP binding site [chemical binding]; other site 693970002957 putative Mg++ binding site [ion binding]; other site 693970002958 AAA domain; Region: AAA_13; pfam13166 693970002959 AAA domain; Region: AAA_13; pfam13166 693970002960 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 693970002961 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 693970002962 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 693970002963 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 693970002964 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 693970002965 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 693970002966 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 693970002967 HsdM N-terminal domain; Region: HsdM_N; pfam12161 693970002968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970002969 S-adenosylmethionine binding site [chemical binding]; other site 693970002970 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 693970002971 putative active site [active] 693970002972 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693970002973 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970002974 non-specific DNA binding site [nucleotide binding]; other site 693970002975 salt bridge; other site 693970002976 sequence-specific DNA binding site [nucleotide binding]; other site 693970002977 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 693970002978 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693970002979 active site 693970002980 catalytic residues [active] 693970002981 DNA binding site [nucleotide binding] 693970002982 Int/Topo IB signature motif; other site 693970002983 S-adenosylmethionine synthetase; Validated; Region: PRK05250 693970002984 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 693970002985 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 693970002986 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 693970002987 transketolase; Reviewed; Region: PRK12753 693970002988 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 693970002989 TPP-binding site [chemical binding]; other site 693970002990 dimer interface [polypeptide binding]; other site 693970002991 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693970002992 PYR/PP interface [polypeptide binding]; other site 693970002993 dimer interface [polypeptide binding]; other site 693970002994 TPP binding site [chemical binding]; other site 693970002995 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693970002996 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 693970002997 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 693970002998 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 693970002999 Phosphoglycerate kinase; Region: PGK; pfam00162 693970003000 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 693970003001 substrate binding site [chemical binding]; other site 693970003002 hinge regions; other site 693970003003 ADP binding site [chemical binding]; other site 693970003004 catalytic site [active] 693970003005 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 693970003006 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 693970003007 intersubunit interface [polypeptide binding]; other site 693970003008 active site 693970003009 zinc binding site [ion binding]; other site 693970003010 Na+ binding site [ion binding]; other site 693970003011 Protein of unknown function, DUF481; Region: DUF481; pfam04338 693970003012 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 693970003013 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 693970003014 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 693970003015 DNA binding site [nucleotide binding] 693970003016 PAS domain; Region: PAS_9; pfam13426 693970003017 PAS domain; Region: PAS_9; pfam13426 693970003018 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970003019 I-site; other site 693970003020 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 693970003021 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693970003022 FeS/SAM binding site; other site 693970003023 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693970003024 Protein export membrane protein; Region: SecD_SecF; cl14618 693970003025 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693970003026 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970003027 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693970003028 DEAD-like helicases superfamily; Region: DEXDc; smart00487 693970003029 ATP binding site [chemical binding]; other site 693970003030 Mg++ binding site [ion binding]; other site 693970003031 motif III; other site 693970003032 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970003033 nucleotide binding region [chemical binding]; other site 693970003034 ATP-binding site [chemical binding]; other site 693970003035 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 693970003036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970003037 S-adenosylmethionine binding site [chemical binding]; other site 693970003038 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 693970003039 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 693970003040 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 693970003041 active site 693970003042 Int/Topo IB signature motif; other site 693970003043 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 693970003044 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 693970003045 dimerization domain [polypeptide binding]; other site 693970003046 dimer interface [polypeptide binding]; other site 693970003047 catalytic residues [active] 693970003048 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 693970003049 DHH family; Region: DHH; pfam01368 693970003050 DHHA1 domain; Region: DHHA1; pfam02272 693970003051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970003052 Coenzyme A binding pocket [chemical binding]; other site 693970003053 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 693970003054 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 693970003055 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 693970003056 catalytic residue [active] 693970003057 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 693970003058 catalytic residues [active] 693970003059 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693970003060 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693970003061 peroxiredoxin; Region: AhpC; TIGR03137 693970003062 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 693970003063 dimer interface [polypeptide binding]; other site 693970003064 decamer (pentamer of dimers) interface [polypeptide binding]; other site 693970003065 catalytic triad [active] 693970003066 peroxidatic and resolving cysteines [active] 693970003067 multifunctional aminopeptidase A; Provisional; Region: PRK00913 693970003068 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 693970003069 interface (dimer of trimers) [polypeptide binding]; other site 693970003070 Substrate-binding/catalytic site; other site 693970003071 Zn-binding sites [ion binding]; other site 693970003072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970003073 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 693970003074 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693970003075 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 693970003076 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 693970003077 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970003078 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970003079 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693970003080 Domain of unknown function (DU1801); Region: DUF1801; cl17490 693970003081 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 693970003082 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 693970003083 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 693970003084 putative ligand binding site [chemical binding]; other site 693970003085 putative NAD binding site [chemical binding]; other site 693970003086 catalytic site [active] 693970003087 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 693970003088 heme-binding residues [chemical binding]; other site 693970003089 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 693970003090 L-aspartate oxidase; Provisional; Region: PRK06175 693970003091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970003092 S-adenosylmethionine binding site [chemical binding]; other site 693970003093 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 693970003094 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 693970003095 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 693970003096 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693970003097 MarR family; Region: MarR; pfam01047 693970003098 FAD dependent oxidoreductase; Region: DAO; pfam01266 693970003099 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 693970003100 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 693970003101 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 693970003102 Chromate transporter; Region: Chromate_transp; pfam02417 693970003103 Cache domain; Region: Cache_2; pfam08269 693970003104 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693970003105 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970003106 dimerization interface [polypeptide binding]; other site 693970003107 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970003108 dimer interface [polypeptide binding]; other site 693970003109 putative CheW interface [polypeptide binding]; other site 693970003110 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 693970003111 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 693970003112 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693970003113 4Fe-4S binding domain; Region: Fer4_6; pfam12837 693970003114 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 693970003115 4Fe-4S binding domain; Region: Fer4; pfam00037 693970003116 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 693970003117 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 693970003118 [4Fe-4S] binding site [ion binding]; other site 693970003119 molybdopterin cofactor binding site; other site 693970003120 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 693970003121 molybdopterin cofactor binding site; other site 693970003122 peptide chain release factor 2; Validated; Region: prfB; PRK00578 693970003123 This domain is found in peptide chain release factors; Region: PCRF; smart00937 693970003124 RF-1 domain; Region: RF-1; pfam00472 693970003125 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 693970003126 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 693970003127 dimer interface [polypeptide binding]; other site 693970003128 putative anticodon binding site; other site 693970003129 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 693970003130 motif 1; other site 693970003131 active site 693970003132 motif 2; other site 693970003133 motif 3; other site 693970003134 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 693970003135 Carbon starvation protein CstA; Region: CstA; pfam02554 693970003136 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 693970003137 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 693970003138 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 693970003139 dimer interface [polypeptide binding]; other site 693970003140 active site 693970003141 heme binding site [chemical binding]; other site 693970003142 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 693970003143 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693970003144 CoenzymeA binding site [chemical binding]; other site 693970003145 subunit interaction site [polypeptide binding]; other site 693970003146 PHB binding site; other site 693970003147 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 693970003148 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 693970003149 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 693970003150 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 693970003151 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 693970003152 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 693970003153 tetramer interface [polypeptide binding]; other site 693970003154 active site 693970003155 Mg2+/Mn2+ binding site [ion binding]; other site 693970003156 Protein of unknown function DUF72; Region: DUF72; cl00777 693970003157 PAS domain S-box; Region: sensory_box; TIGR00229 693970003158 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970003159 putative active site [active] 693970003160 heme pocket [chemical binding]; other site 693970003161 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693970003162 GAF domain; Region: GAF; pfam01590 693970003163 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970003164 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970003165 metal binding site [ion binding]; metal-binding site 693970003166 active site 693970003167 I-site; other site 693970003168 Cache domain; Region: Cache_1; pfam02743 693970003169 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970003170 dimerization interface [polypeptide binding]; other site 693970003171 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693970003172 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970003173 dimer interface [polypeptide binding]; other site 693970003174 putative CheW interface [polypeptide binding]; other site 693970003175 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 693970003176 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 693970003177 Zn binding site [ion binding]; other site 693970003178 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 693970003179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 693970003180 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 693970003181 active site 693970003182 catalytic residues [active] 693970003183 metal binding site [ion binding]; metal-binding site 693970003184 SlyX; Region: SlyX; pfam04102 693970003185 FOG: WD40 repeat [General function prediction only]; Region: COG2319 693970003186 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 693970003187 structural tetrad; other site 693970003188 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 693970003189 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 693970003190 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693970003191 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 693970003192 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 693970003193 generic binding surface II; other site 693970003194 generic binding surface I; other site 693970003195 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 693970003196 putative catalytic site [active] 693970003197 putative metal binding site [ion binding]; other site 693970003198 putative phosphate binding site [ion binding]; other site 693970003199 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693970003200 CoenzymeA binding site [chemical binding]; other site 693970003201 subunit interaction site [polypeptide binding]; other site 693970003202 PHB binding site; other site 693970003203 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 693970003204 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 693970003205 tetramer interface [polypeptide binding]; other site 693970003206 heme binding pocket [chemical binding]; other site 693970003207 NADPH binding site [chemical binding]; other site 693970003208 Predicted membrane protein [Function unknown]; Region: COG2119 693970003209 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 693970003210 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 693970003211 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 693970003212 Chitin binding domain; Region: Chitin_bind_3; pfam03067 693970003213 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 693970003214 aromatic amino acid transport protein; Region: araaP; TIGR00837 693970003215 Peptidase S46; Region: Peptidase_S46; pfam10459 693970003216 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 693970003217 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 693970003218 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 693970003219 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693970003220 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693970003221 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 693970003222 ligand binding site [chemical binding]; other site 693970003223 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 693970003224 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693970003225 RNA binding surface [nucleotide binding]; other site 693970003226 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 693970003227 probable active site [active] 693970003228 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 693970003229 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 693970003230 FMN-binding domain; Region: FMN_bind; pfam04205 693970003231 ApbE family; Region: ApbE; pfam02424 693970003232 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970003233 dimerization interface [polypeptide binding]; other site 693970003234 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693970003235 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970003236 dimer interface [polypeptide binding]; other site 693970003237 putative CheW interface [polypeptide binding]; other site 693970003238 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693970003239 EamA-like transporter family; Region: EamA; pfam00892 693970003240 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693970003241 Helix-turn-helix domain; Region: HTH_18; pfam12833 693970003242 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693970003243 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970003244 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970003245 Integrase core domain; Region: rve; pfam00665 693970003246 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 693970003247 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 693970003248 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 693970003249 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 693970003250 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693970003251 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693970003252 DNA-binding site [nucleotide binding]; DNA binding site 693970003253 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693970003254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970003255 homodimer interface [polypeptide binding]; other site 693970003256 catalytic residue [active] 693970003257 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 693970003258 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693970003259 homodimer interface [polypeptide binding]; other site 693970003260 substrate-cofactor binding pocket; other site 693970003261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970003262 catalytic residue [active] 693970003263 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 693970003264 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 693970003265 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 693970003266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970003267 S-adenosylmethionine binding site [chemical binding]; other site 693970003268 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 693970003269 BolA-like protein; Region: BolA; cl00386 693970003270 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 693970003271 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 693970003272 S-ribosylhomocysteinase; Provisional; Region: PRK02260 693970003273 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693970003274 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970003275 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 693970003276 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 693970003277 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 693970003278 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 693970003279 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 693970003280 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 693970003281 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 693970003282 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 693970003283 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 693970003284 FAD binding pocket [chemical binding]; other site 693970003285 FAD binding motif [chemical binding]; other site 693970003286 phosphate binding motif [ion binding]; other site 693970003287 beta-alpha-beta structure motif; other site 693970003288 NAD binding pocket [chemical binding]; other site 693970003289 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 693970003290 ApbE family; Region: ApbE; pfam02424 693970003291 Protein of unknown function (DUF539); Region: DUF539; cl01129 693970003292 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 693970003293 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 693970003294 heme binding site [chemical binding]; other site 693970003295 ferroxidase pore; other site 693970003296 ferroxidase diiron center [ion binding]; other site 693970003297 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 693970003298 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 693970003299 heme binding site [chemical binding]; other site 693970003300 ferroxidase pore; other site 693970003301 ferroxidase diiron center [ion binding]; other site 693970003302 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970003303 dimerization interface [polypeptide binding]; other site 693970003304 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970003305 dimer interface [polypeptide binding]; other site 693970003306 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 693970003307 putative CheW interface [polypeptide binding]; other site 693970003308 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 693970003309 active site 693970003310 DNA polymerase IV; Validated; Region: PRK02406 693970003311 DNA binding site [nucleotide binding] 693970003312 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693970003313 EamA-like transporter family; Region: EamA; pfam00892 693970003314 EamA-like transporter family; Region: EamA; pfam00892 693970003315 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 693970003316 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693970003317 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970003318 dimerization interface [polypeptide binding]; other site 693970003319 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970003320 dimer interface [polypeptide binding]; other site 693970003321 putative CheW interface [polypeptide binding]; other site 693970003322 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 693970003323 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 693970003324 metal binding site [ion binding]; metal-binding site 693970003325 dimer interface [polypeptide binding]; other site 693970003326 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 693970003327 interface (dimer of trimers) [polypeptide binding]; other site 693970003328 Substrate-binding/catalytic site; other site 693970003329 Zn-binding sites [ion binding]; other site 693970003330 Protein of unknown function (DUF2956); Region: DUF2956; pfam11169 693970003331 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 693970003332 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693970003333 Walker A/P-loop; other site 693970003334 ATP binding site [chemical binding]; other site 693970003335 Q-loop/lid; other site 693970003336 ABC transporter signature motif; other site 693970003337 Walker B; other site 693970003338 D-loop; other site 693970003339 H-loop/switch region; other site 693970003340 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 693970003341 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693970003342 ABC-ATPase subunit interface; other site 693970003343 dimer interface [polypeptide binding]; other site 693970003344 putative PBP binding regions; other site 693970003345 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 693970003346 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 693970003347 putative hemin binding site; other site 693970003348 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 693970003349 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 693970003350 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 693970003351 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 693970003352 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 693970003353 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693970003354 N-terminal plug; other site 693970003355 ligand-binding site [chemical binding]; other site 693970003356 Haem utilisation ChuX/HutX; Region: ChuX_HutX; pfam06228 693970003357 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 693970003358 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 693970003359 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 693970003360 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693970003361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970003362 Walker A/P-loop; other site 693970003363 ATP binding site [chemical binding]; other site 693970003364 Q-loop/lid; other site 693970003365 ABC transporter signature motif; other site 693970003366 Walker B; other site 693970003367 D-loop; other site 693970003368 H-loop/switch region; other site 693970003369 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 693970003370 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 693970003371 acyl-activating enzyme (AAE) consensus motif; other site 693970003372 putative AMP binding site [chemical binding]; other site 693970003373 putative active site [active] 693970003374 putative CoA binding site [chemical binding]; other site 693970003375 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 693970003376 4Fe-4S binding domain; Region: Fer4_5; pfam12801 693970003377 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 693970003378 PAS domain S-box; Region: sensory_box; TIGR00229 693970003379 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970003380 putative active site [active] 693970003381 heme pocket [chemical binding]; other site 693970003382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970003383 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 693970003384 Walker A motif; other site 693970003385 ATP binding site [chemical binding]; other site 693970003386 Walker B motif; other site 693970003387 arginine finger; other site 693970003388 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693970003389 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693970003390 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970003391 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970003392 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 693970003393 DsbD alpha interface [polypeptide binding]; other site 693970003394 catalytic residues [active] 693970003395 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 693970003396 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 693970003397 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693970003398 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 693970003399 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 693970003400 ligand binding site [chemical binding]; other site 693970003401 active site 693970003402 UGI interface [polypeptide binding]; other site 693970003403 catalytic site [active] 693970003404 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 693970003405 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 693970003406 substrate binding pocket [chemical binding]; other site 693970003407 chain length determination region; other site 693970003408 substrate-Mg2+ binding site; other site 693970003409 catalytic residues [active] 693970003410 aspartate-rich region 1; other site 693970003411 active site lid residues [active] 693970003412 aspartate-rich region 2; other site 693970003413 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 693970003414 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 693970003415 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 693970003416 GTPase CgtA; Reviewed; Region: obgE; PRK12298 693970003417 GTP1/OBG; Region: GTP1_OBG; pfam01018 693970003418 Obg GTPase; Region: Obg; cd01898 693970003419 G1 box; other site 693970003420 GTP/Mg2+ binding site [chemical binding]; other site 693970003421 Switch I region; other site 693970003422 G2 box; other site 693970003423 G3 box; other site 693970003424 Switch II region; other site 693970003425 G4 box; other site 693970003426 G5 box; other site 693970003427 Uncharacterized conserved protein [Function unknown]; Region: COG2966 693970003428 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 693970003429 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 693970003430 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 693970003431 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 693970003432 NADP+ binding site [chemical binding]; other site 693970003433 folate binding site [chemical binding]; other site 693970003434 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 693970003435 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970003436 dimerization interface [polypeptide binding]; other site 693970003437 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693970003438 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970003439 dimer interface [polypeptide binding]; other site 693970003440 putative CheW interface [polypeptide binding]; other site 693970003441 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 693970003442 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 693970003443 active site 693970003444 metal binding site [ion binding]; metal-binding site 693970003445 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 693970003446 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 693970003447 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 693970003448 S-adenosylmethionine binding site [chemical binding]; other site 693970003449 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 693970003450 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 693970003451 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 693970003452 SurA N-terminal domain; Region: SurA_N; pfam09312 693970003453 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 693970003454 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 693970003455 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 693970003456 OstA-like protein; Region: OstA; cl00844 693970003457 Organic solvent tolerance protein; Region: OstA_C; pfam04453 693970003458 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 693970003459 Phosphotransferase enzyme family; Region: APH; pfam01636 693970003460 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 693970003461 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 693970003462 Substrate binding site; other site 693970003463 metal-binding site 693970003464 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 693970003465 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 693970003466 putative metal binding site [ion binding]; other site 693970003467 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693970003468 HSP70 interaction site [polypeptide binding]; other site 693970003469 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 693970003470 glycerate dehydrogenase; Provisional; Region: PRK06487 693970003471 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 693970003472 putative ligand binding site [chemical binding]; other site 693970003473 putative NAD binding site [chemical binding]; other site 693970003474 catalytic site [active] 693970003475 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 693970003476 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693970003477 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693970003478 active site 693970003479 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 693970003480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693970003481 ATP-grasp domain; Region: ATP-grasp; pfam02222 693970003482 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 693970003483 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 693970003484 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693970003485 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970003486 Ycf46; Provisional; Region: ycf46; CHL00195 693970003487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970003488 Walker A motif; other site 693970003489 ATP binding site [chemical binding]; other site 693970003490 Walker B motif; other site 693970003491 arginine finger; other site 693970003492 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 693970003493 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 693970003494 Walker A/P-loop; other site 693970003495 ATP binding site [chemical binding]; other site 693970003496 Q-loop/lid; other site 693970003497 ABC transporter signature motif; other site 693970003498 Walker B; other site 693970003499 D-loop; other site 693970003500 H-loop/switch region; other site 693970003501 TOBE-like domain; Region: TOBE_3; pfam12857 693970003502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693970003503 dimer interface [polypeptide binding]; other site 693970003504 conserved gate region; other site 693970003505 putative PBP binding loops; other site 693970003506 ABC-ATPase subunit interface; other site 693970003507 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 693970003508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693970003509 dimer interface [polypeptide binding]; other site 693970003510 conserved gate region; other site 693970003511 putative PBP binding loops; other site 693970003512 ABC-ATPase subunit interface; other site 693970003513 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CysP; COG4150 693970003514 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 693970003515 cysteine synthase B; Region: cysM; TIGR01138 693970003516 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 693970003517 dimer interface [polypeptide binding]; other site 693970003518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970003519 catalytic residue [active] 693970003520 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 693970003521 Predicted Fe-S protein [General function prediction only]; Region: COG3313 693970003522 sensor protein RstB; Provisional; Region: PRK10604 693970003523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970003524 dimer interface [polypeptide binding]; other site 693970003525 phosphorylation site [posttranslational modification] 693970003526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970003527 ATP binding site [chemical binding]; other site 693970003528 Mg2+ binding site [ion binding]; other site 693970003529 G-X-G motif; other site 693970003530 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 693970003531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970003532 active site 693970003533 phosphorylation site [posttranslational modification] 693970003534 intermolecular recognition site; other site 693970003535 dimerization interface [polypeptide binding]; other site 693970003536 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693970003537 DNA binding site [nucleotide binding] 693970003538 Protein of unknown function (DUF3019); Region: DUF3019; pfam11456 693970003539 MltA-interacting protein MipA; Region: MipA; cl01504 693970003540 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 693970003541 YcxB-like protein; Region: YcxB; pfam14317 693970003542 Domain of unknown function (DUF1971); Region: DUF1971; pfam09313 693970003543 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970003544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970003545 Walker A motif; other site 693970003546 ATP binding site [chemical binding]; other site 693970003547 Walker B motif; other site 693970003548 Integrase core domain; Region: rve; pfam00665 693970003549 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693970003550 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 693970003551 active site 693970003552 metal binding site [ion binding]; metal-binding site 693970003553 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693970003554 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 693970003555 Predicted transcriptional regulator [Transcription]; Region: COG2345 693970003556 Transcriptional regulator PadR-like family; Region: PadR; cl17335 693970003557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970003558 TPR motif; other site 693970003559 TPR repeat; Region: TPR_11; pfam13414 693970003560 binding surface 693970003561 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 693970003562 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693970003563 RNA binding surface [nucleotide binding]; other site 693970003564 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 693970003565 active site 693970003566 uracil binding [chemical binding]; other site 693970003567 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 693970003568 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 693970003569 heme-binding site [chemical binding]; other site 693970003570 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 693970003571 FAD binding pocket [chemical binding]; other site 693970003572 FAD binding motif [chemical binding]; other site 693970003573 phosphate binding motif [ion binding]; other site 693970003574 beta-alpha-beta structure motif; other site 693970003575 NAD binding pocket [chemical binding]; other site 693970003576 Heme binding pocket [chemical binding]; other site 693970003577 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 693970003578 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693970003579 HAMP domain; Region: HAMP; pfam00672 693970003580 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970003581 dimer interface [polypeptide binding]; other site 693970003582 putative CheW interface [polypeptide binding]; other site 693970003583 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 693970003584 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693970003585 RNA binding surface [nucleotide binding]; other site 693970003586 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693970003587 active site 693970003588 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 693970003589 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 693970003590 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 693970003591 Clp amino terminal domain; Region: Clp_N; pfam02861 693970003592 Clp amino terminal domain; Region: Clp_N; pfam02861 693970003593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970003594 Walker A motif; other site 693970003595 ATP binding site [chemical binding]; other site 693970003596 Walker B motif; other site 693970003597 arginine finger; other site 693970003598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970003599 Walker A motif; other site 693970003600 ATP binding site [chemical binding]; other site 693970003601 Walker B motif; other site 693970003602 arginine finger; other site 693970003603 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 693970003604 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 693970003605 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 693970003606 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 693970003607 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970003608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970003609 Walker A motif; other site 693970003610 ATP binding site [chemical binding]; other site 693970003611 Walker B motif; other site 693970003612 Integrase core domain; Region: rve; pfam00665 693970003613 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 693970003614 oxaloacetate decarboxylase; Provisional; Region: PRK14040 693970003615 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 693970003616 active site 693970003617 catalytic residues [active] 693970003618 metal binding site [ion binding]; metal-binding site 693970003619 homodimer binding site [polypeptide binding]; other site 693970003620 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693970003621 carboxyltransferase (CT) interaction site; other site 693970003622 biotinylation site [posttranslational modification]; other site 693970003623 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 693970003624 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693970003625 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 693970003626 Predicted membrane protein [Function unknown]; Region: COG1238 693970003627 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693970003628 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693970003629 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693970003630 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693970003631 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693970003632 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693970003633 glutamate--cysteine ligase; Provisional; Region: PRK02107 693970003634 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693970003635 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693970003636 catalytic residue [active] 693970003637 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693970003638 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 693970003639 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970003640 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970003641 metal binding site [ion binding]; metal-binding site 693970003642 active site 693970003643 I-site; other site 693970003644 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 693970003645 ATP-grasp domain; Region: ATP-grasp; pfam02222 693970003646 AIR carboxylase; Region: AIRC; pfam00731 693970003647 putative transporter; Provisional; Region: PRK11660 693970003648 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 693970003649 Sulfate transporter family; Region: Sulfate_transp; pfam00916 693970003650 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 693970003651 von Willebrand factor; Region: vWF_A; pfam12450 693970003652 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 693970003653 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 693970003654 metal ion-dependent adhesion site (MIDAS); other site 693970003655 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 693970003656 RNA polymerase sigma factor; Provisional; Region: PRK12513 693970003657 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693970003658 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 693970003659 DNA binding residues [nucleotide binding] 693970003660 Hemerythrin-like domain; Region: Hr-like; cd12108 693970003661 Fe binding site [ion binding]; other site 693970003662 Protein of unknown function (DUF3545); Region: DUF3545; pfam12065 693970003663 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 693970003664 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 693970003665 active site 693970003666 dimer interface [polypeptide binding]; other site 693970003667 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 693970003668 dimer interface [polypeptide binding]; other site 693970003669 active site 693970003670 transaldolase-like protein; Provisional; Region: PTZ00411 693970003671 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 693970003672 active site 693970003673 dimer interface [polypeptide binding]; other site 693970003674 catalytic residue [active] 693970003675 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 693970003676 outer membrane protein A; Reviewed; Region: PRK10808 693970003677 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693970003678 ligand binding site [chemical binding]; other site 693970003679 putative phosphoketolase; Provisional; Region: PRK05261 693970003680 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 693970003681 TPP-binding site; other site 693970003682 XFP C-terminal domain; Region: XFP_C; pfam09363 693970003683 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693970003684 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 693970003685 hypothetical protein; Validated; Region: PRK02101 693970003686 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 693970003687 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 693970003688 PA/protease or protease-like domain interface [polypeptide binding]; other site 693970003689 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 693970003690 Peptidase family M28; Region: Peptidase_M28; pfam04389 693970003691 metal binding site [ion binding]; metal-binding site 693970003692 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693970003693 dimerization interface [polypeptide binding]; other site 693970003694 putative DNA binding site [nucleotide binding]; other site 693970003695 putative Zn2+ binding site [ion binding]; other site 693970003696 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 693970003697 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 693970003698 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 693970003699 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 693970003700 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 693970003701 active site 693970003702 Riboflavin kinase; Region: Flavokinase; smart00904 693970003703 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 693970003704 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 693970003705 HIGH motif; other site 693970003706 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 693970003707 active site 693970003708 KMSKS motif; other site 693970003709 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 693970003710 tRNA binding surface [nucleotide binding]; other site 693970003711 anticodon binding site; other site 693970003712 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 693970003713 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 693970003714 lipoprotein signal peptidase; Provisional; Region: PRK14787 693970003715 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 693970003716 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693970003717 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 693970003718 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 693970003719 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 693970003720 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 693970003721 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 693970003722 PilX N-terminal; Region: PilX_N; pfam14341 693970003723 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 693970003724 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 693970003725 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 693970003726 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 693970003727 Type II transport protein GspH; Region: GspH; pfam12019 693970003728 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970003729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970003730 Walker A motif; other site 693970003731 ATP binding site [chemical binding]; other site 693970003732 Walker B motif; other site 693970003733 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 693970003734 Nitrogen regulatory protein P-II; Region: P-II; smart00938 693970003735 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 693970003736 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693970003737 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693970003738 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693970003739 DNA binding site [nucleotide binding] 693970003740 domain linker motif; other site 693970003741 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 693970003742 putative ligand binding site [chemical binding]; other site 693970003743 putative dimerization interface [polypeptide binding]; other site 693970003744 Transposase; Region: HTH_Tnp_1; pfam01527 693970003745 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970003746 putative transposase OrfB; Reviewed; Region: PHA02517 693970003747 HTH-like domain; Region: HTH_21; pfam13276 693970003748 Integrase core domain; Region: rve; pfam00665 693970003749 Integrase core domain; Region: rve_2; pfam13333 693970003750 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970003751 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970003752 Integrase core domain; Region: rve; pfam00665 693970003753 SapC; Region: SapC; pfam07277 693970003754 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 693970003755 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 693970003756 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693970003757 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 693970003758 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693970003759 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970003760 dimerization interface [polypeptide binding]; other site 693970003761 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693970003762 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970003763 dimer interface [polypeptide binding]; other site 693970003764 putative CheW interface [polypeptide binding]; other site 693970003765 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 693970003766 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 693970003767 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 693970003768 dimer interface [polypeptide binding]; other site 693970003769 active site 693970003770 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 693970003771 dimer interface [polypeptide binding]; other site 693970003772 active site 693970003773 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 693970003774 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 693970003775 active site 693970003776 dimer interface [polypeptide binding]; other site 693970003777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 693970003778 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 693970003779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970003780 putative substrate translocation pore; other site 693970003781 conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001 693970003782 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 693970003783 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 693970003784 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 693970003785 tetrameric interface [polypeptide binding]; other site 693970003786 NAD binding site [chemical binding]; other site 693970003787 catalytic residues [active] 693970003788 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 693970003789 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693970003790 inhibitor-cofactor binding pocket; inhibition site 693970003791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970003792 catalytic residue [active] 693970003793 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 693970003794 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 693970003795 NAD(P) binding site [chemical binding]; other site 693970003796 catalytic residues [active] 693970003797 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 693970003798 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693970003799 Transposase; Region: HTH_Tnp_1; cl17663 693970003800 Winged helix-turn helix; Region: HTH_29; pfam13551 693970003801 Homeodomain-like domain; Region: HTH_32; pfam13565 693970003802 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970003803 Integrase core domain; Region: rve; pfam00665 693970003804 Integrase core domain; Region: rve_3; pfam13683 693970003805 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 693970003806 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 693970003807 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 693970003808 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 693970003809 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693970003810 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 693970003811 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970003812 non-specific DNA binding site [nucleotide binding]; other site 693970003813 salt bridge; other site 693970003814 sequence-specific DNA binding site [nucleotide binding]; other site 693970003815 Cupin domain; Region: Cupin_2; pfam07883 693970003816 Peptidase C26; Region: Peptidase_C26; pfam07722 693970003817 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 693970003818 catalytic triad [active] 693970003819 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 693970003820 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693970003821 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 693970003822 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693970003823 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 693970003824 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970003825 Walker A/P-loop; other site 693970003826 ATP binding site [chemical binding]; other site 693970003827 Q-loop/lid; other site 693970003828 ABC transporter signature motif; other site 693970003829 Walker B; other site 693970003830 D-loop; other site 693970003831 H-loop/switch region; other site 693970003832 TOBE domain; Region: TOBE_2; pfam08402 693970003833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693970003834 dimer interface [polypeptide binding]; other site 693970003835 conserved gate region; other site 693970003836 putative PBP binding loops; other site 693970003837 ABC-ATPase subunit interface; other site 693970003838 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693970003839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693970003840 dimer interface [polypeptide binding]; other site 693970003841 conserved gate region; other site 693970003842 putative PBP binding loops; other site 693970003843 ABC-ATPase subunit interface; other site 693970003844 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 693970003845 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693970003846 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 693970003847 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 693970003848 tetramerization interface [polypeptide binding]; other site 693970003849 NAD(P) binding site [chemical binding]; other site 693970003850 catalytic residues [active] 693970003851 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 693970003852 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693970003853 inhibitor-cofactor binding pocket; inhibition site 693970003854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970003855 catalytic residue [active] 693970003856 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 693970003857 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 693970003858 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 693970003859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970003860 putative substrate translocation pore; other site 693970003861 Transposase; Region: HTH_Tnp_1; pfam01527 693970003862 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970003863 putative transposase OrfB; Reviewed; Region: PHA02517 693970003864 HTH-like domain; Region: HTH_21; pfam13276 693970003865 Integrase core domain; Region: rve; pfam00665 693970003866 Integrase core domain; Region: rve_2; pfam13333 693970003867 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 693970003868 Cupin-like domain; Region: Cupin_8; pfam13621 693970003869 SapC; Region: SapC; pfam07277 693970003870 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 693970003871 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 693970003872 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970003873 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970003874 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970003875 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693970003876 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693970003877 DNA binding site [nucleotide binding] 693970003878 domain linker motif; other site 693970003879 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 693970003880 dimerization interface (closed form) [polypeptide binding]; other site 693970003881 ligand binding site [chemical binding]; other site 693970003882 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 693970003883 putative symporter YagG; Provisional; Region: PRK09669 693970003884 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 693970003885 beta-galactosidase; Region: BGL; TIGR03356 693970003886 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 693970003887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970003888 putative substrate translocation pore; other site 693970003889 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 693970003890 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 693970003891 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 693970003892 fructokinase; Reviewed; Region: PRK09557 693970003893 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693970003894 nucleotide binding site [chemical binding]; other site 693970003895 Acetokinase family; Region: Acetate_kinase; cl17229 693970003896 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 693970003897 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693970003898 active site 693970003899 DNA binding site [nucleotide binding] 693970003900 Int/Topo IB signature motif; other site 693970003901 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970003902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970003903 Walker A motif; other site 693970003904 ATP binding site [chemical binding]; other site 693970003905 Walker B motif; other site 693970003906 Integrase core domain; Region: rve; pfam00665 693970003907 Transposase; Region: HTH_Tnp_1; cl17663 693970003908 Winged helix-turn helix; Region: HTH_29; pfam13551 693970003909 Homeodomain-like domain; Region: HTH_32; pfam13565 693970003910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970003911 Integrase core domain; Region: rve; pfam00665 693970003912 Integrase core domain; Region: rve_3; pfam13683 693970003913 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 693970003914 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 693970003915 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 693970003916 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 693970003917 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693970003918 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693970003919 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693970003920 DNA binding residues [nucleotide binding] 693970003921 DNA primase; Validated; Region: dnaG; PRK05667 693970003922 CHC2 zinc finger; Region: zf-CHC2; pfam01807 693970003923 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 693970003924 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 693970003925 active site 693970003926 metal binding site [ion binding]; metal-binding site 693970003927 interdomain interaction site; other site 693970003928 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 693970003929 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 693970003930 Yqey-like protein; Region: YqeY; pfam09424 693970003931 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 693970003932 UGMP family protein; Validated; Region: PRK09604 693970003933 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 693970003934 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 693970003935 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 693970003936 homooctamer interface [polypeptide binding]; other site 693970003937 active site 693970003938 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 693970003939 catalytic center binding site [active] 693970003940 ATP binding site [chemical binding]; other site 693970003941 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 693970003942 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 693970003943 Methyltransferase domain; Region: Methyltransf_11; pfam08241 693970003944 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 693970003945 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 693970003946 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 693970003947 active site 693970003948 NTP binding site [chemical binding]; other site 693970003949 metal binding triad [ion binding]; metal-binding site 693970003950 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 693970003951 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693970003952 Zn2+ binding site [ion binding]; other site 693970003953 Mg2+ binding site [ion binding]; other site 693970003954 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 693970003955 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970003956 Walker A motif; other site 693970003957 ATP binding site [chemical binding]; other site 693970003958 Walker B motif; other site 693970003959 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693970003960 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 693970003961 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 693970003962 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 693970003963 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693970003964 inhibitor-cofactor binding pocket; inhibition site 693970003965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970003966 catalytic residue [active] 693970003967 aspartate carbamoyltransferase; Provisional; Region: PRK08192 693970003968 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 693970003969 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 693970003970 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 693970003971 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 693970003972 Cl- selectivity filter; other site 693970003973 Cl- binding residues [ion binding]; other site 693970003974 pore gating glutamate residue; other site 693970003975 dimer interface [polypeptide binding]; other site 693970003976 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 693970003977 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 693970003978 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693970003979 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 693970003980 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 693970003981 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 693970003982 amphipathic channel; other site 693970003983 Asn-Pro-Ala signature motifs; other site 693970003984 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 693970003985 putative peptidase; Provisional; Region: PRK11649 693970003986 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 693970003987 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 693970003988 Peptidase family M23; Region: Peptidase_M23; pfam01551 693970003989 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 693970003990 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 693970003991 active site 693970003992 HIGH motif; other site 693970003993 dimer interface [polypeptide binding]; other site 693970003994 KMSKS motif; other site 693970003995 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693970003996 RNA binding surface [nucleotide binding]; other site 693970003997 SnoaL-like domain; Region: SnoaL_2; pfam12680 693970003998 hypothetical protein; Provisional; Region: PRK10578 693970003999 UPF0126 domain; Region: UPF0126; pfam03458 693970004000 UPF0126 domain; Region: UPF0126; pfam03458 693970004001 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 693970004002 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 693970004003 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 693970004004 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 693970004005 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693970004006 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693970004007 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693970004008 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 693970004009 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 693970004010 active site 693970004011 dimer interface [polypeptide binding]; other site 693970004012 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 693970004013 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 693970004014 active site 693970004015 FMN binding site [chemical binding]; other site 693970004016 substrate binding site [chemical binding]; other site 693970004017 3Fe-4S cluster binding site [ion binding]; other site 693970004018 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 693970004019 domain interface; other site 693970004020 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 693970004021 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693970004022 FeS/SAM binding site; other site 693970004023 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693970004024 putative binding surface; other site 693970004025 active site 693970004026 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970004027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970004028 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 693970004029 dimerization interface [polypeptide binding]; other site 693970004030 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693970004031 cyclase homology domain; Region: CHD; cd07302 693970004032 nucleotidyl binding site; other site 693970004033 metal binding site [ion binding]; metal-binding site 693970004034 dimer interface [polypeptide binding]; other site 693970004035 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 693970004036 putative DNA-binding cleft [nucleotide binding]; other site 693970004037 putative DNA clevage site; other site 693970004038 molecular lever; other site 693970004039 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 693970004040 putative active site [active] 693970004041 Ap4A binding site [chemical binding]; other site 693970004042 nudix motif; other site 693970004043 putative metal binding site [ion binding]; other site 693970004044 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 693970004045 GAF domain; Region: GAF; pfam01590 693970004046 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 693970004047 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693970004048 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693970004049 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693970004050 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 693970004051 thymidylate synthase; Reviewed; Region: thyA; PRK01827 693970004052 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 693970004053 dimerization interface [polypeptide binding]; other site 693970004054 active site 693970004055 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 693970004056 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 693970004057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970004058 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693970004059 dimerization interface [polypeptide binding]; other site 693970004060 Uncharacterized conserved protein [Function unknown]; Region: COG2938 693970004061 L-aspartate oxidase; Provisional; Region: PRK09077 693970004062 L-aspartate oxidase; Provisional; Region: PRK06175 693970004063 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 693970004064 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 693970004065 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693970004066 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693970004067 DNA binding residues [nucleotide binding] 693970004068 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 693970004069 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 693970004070 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 693970004071 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 693970004072 anti-sigma E factor; Provisional; Region: rseB; PRK09455 693970004073 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 693970004074 GTP-binding protein LepA; Provisional; Region: PRK05433 693970004075 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 693970004076 G1 box; other site 693970004077 putative GEF interaction site [polypeptide binding]; other site 693970004078 GTP/Mg2+ binding site [chemical binding]; other site 693970004079 Switch I region; other site 693970004080 G2 box; other site 693970004081 G3 box; other site 693970004082 Switch II region; other site 693970004083 G4 box; other site 693970004084 G5 box; other site 693970004085 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 693970004086 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 693970004087 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 693970004088 signal peptidase I; Provisional; Region: PRK10861 693970004089 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693970004090 Catalytic site [active] 693970004091 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693970004092 ribonuclease III; Reviewed; Region: rnc; PRK00102 693970004093 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 693970004094 dimerization interface [polypeptide binding]; other site 693970004095 active site 693970004096 metal binding site [ion binding]; metal-binding site 693970004097 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 693970004098 dsRNA binding site [nucleotide binding]; other site 693970004099 GTPase Era; Reviewed; Region: era; PRK00089 693970004100 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 693970004101 G1 box; other site 693970004102 GTP/Mg2+ binding site [chemical binding]; other site 693970004103 Switch I region; other site 693970004104 G2 box; other site 693970004105 Switch II region; other site 693970004106 G3 box; other site 693970004107 G4 box; other site 693970004108 G5 box; other site 693970004109 KH domain; Region: KH_2; pfam07650 693970004110 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 693970004111 Recombination protein O N terminal; Region: RecO_N; pfam11967 693970004112 Recombination protein O C terminal; Region: RecO_C; pfam02565 693970004113 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 693970004114 active site 693970004115 hydrophilic channel; other site 693970004116 dimerization interface [polypeptide binding]; other site 693970004117 catalytic residues [active] 693970004118 active site lid [active] 693970004119 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 693970004120 Protein of unknown function (DUF962); Region: DUF962; cl01879 693970004121 Domain of unknown function DUF21; Region: DUF21; pfam01595 693970004122 hypothetical protein; Provisional; Region: PRK11573 693970004123 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693970004124 Transporter associated domain; Region: CorC_HlyC; smart01091 693970004125 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 693970004126 signal recognition particle protein; Provisional; Region: PRK10867 693970004127 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 693970004128 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 693970004129 P loop; other site 693970004130 GTP binding site [chemical binding]; other site 693970004131 Signal peptide binding domain; Region: SRP_SPB; pfam02978 693970004132 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 693970004133 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 693970004134 RimM N-terminal domain; Region: RimM; pfam01782 693970004135 PRC-barrel domain; Region: PRC; pfam05239 693970004136 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 693970004137 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 693970004138 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 693970004139 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 693970004140 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 693970004141 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 693970004142 prephenate dehydrogenase; Validated; Region: PRK08507 693970004143 hybrid cluster protein; Provisional; Region: PRK05290 693970004144 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693970004145 ACS interaction site; other site 693970004146 CODH interaction site; other site 693970004147 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 693970004148 hybrid metal cluster; other site 693970004149 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 693970004150 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 693970004151 FAD binding pocket [chemical binding]; other site 693970004152 FAD binding motif [chemical binding]; other site 693970004153 phosphate binding motif [ion binding]; other site 693970004154 beta-alpha-beta structure motif; other site 693970004155 NAD binding pocket [chemical binding]; other site 693970004156 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693970004157 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 693970004158 catalytic loop [active] 693970004159 iron binding site [ion binding]; other site 693970004160 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 693970004161 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 693970004162 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 693970004163 Prephenate dehydratase; Region: PDT; pfam00800 693970004164 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 693970004165 putative L-Phe binding site [chemical binding]; other site 693970004166 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 693970004167 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 693970004168 30S subunit binding site; other site 693970004169 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 693970004170 Cytochrome C' Region: Cytochrom_C_2; pfam01322 693970004171 Trp repressor protein; Region: Trp_repressor; pfam01371 693970004172 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 693970004173 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693970004174 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 693970004175 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 693970004176 putative catalytic residues [active] 693970004177 putative nucleotide binding site [chemical binding]; other site 693970004178 putative aspartate binding site [chemical binding]; other site 693970004179 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 693970004180 dimer interface [polypeptide binding]; other site 693970004181 putative threonine allosteric regulatory site; other site 693970004182 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 693970004183 putative threonine allosteric regulatory site; other site 693970004184 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 693970004185 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 693970004186 homoserine kinase; Provisional; Region: PRK01212 693970004187 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 693970004188 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 693970004189 threonine synthase; Validated; Region: PRK09225 693970004190 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 693970004191 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693970004192 catalytic residue [active] 693970004193 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693970004194 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693970004195 substrate binding pocket [chemical binding]; other site 693970004196 membrane-bound complex binding site; other site 693970004197 hinge residues; other site 693970004198 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 693970004199 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693970004200 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693970004201 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 693970004202 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 693970004203 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 693970004204 protein binding site [polypeptide binding]; other site 693970004205 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 693970004206 Domain interface; other site 693970004207 Peptide binding site; other site 693970004208 Active site tetrad [active] 693970004209 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 693970004210 OsmC-like protein; Region: OsmC; cl00767 693970004211 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 693970004212 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 693970004213 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 693970004214 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 693970004215 PAS domain; Region: PAS_9; pfam13426 693970004216 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970004217 putative active site [active] 693970004218 heme pocket [chemical binding]; other site 693970004219 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693970004220 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970004221 dimer interface [polypeptide binding]; other site 693970004222 putative CheW interface [polypeptide binding]; other site 693970004223 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 693970004224 30S subunit binding site; other site 693970004225 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693970004226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970004227 active site 693970004228 phosphorylation site [posttranslational modification] 693970004229 intermolecular recognition site; other site 693970004230 dimerization interface [polypeptide binding]; other site 693970004231 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693970004232 dimerization interface [polypeptide binding]; other site 693970004233 DNA binding residues [nucleotide binding] 693970004234 Histidine kinase; Region: HisKA_3; pfam07730 693970004235 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 693970004236 Mg2+ binding site [ion binding]; other site 693970004237 G-X-G motif; other site 693970004238 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 693970004239 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 693970004240 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 693970004241 hypothetical protein; Provisional; Region: PRK12378 693970004242 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693970004243 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970004244 dimer interface [polypeptide binding]; other site 693970004245 putative CheW interface [polypeptide binding]; other site 693970004246 Protein of unknown function (DUF2375); Region: DUF2375; pfam09558 693970004247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693970004248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693970004249 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693970004250 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 693970004251 FMN binding site [chemical binding]; other site 693970004252 active site 693970004253 substrate binding site [chemical binding]; other site 693970004254 catalytic residue [active] 693970004255 AAA domain; Region: AAA_32; pfam13654 693970004256 ATP-dependent protease Lon; Provisional; Region: PRK13765 693970004257 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 693970004258 PAS fold; Region: PAS; pfam00989 693970004259 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970004260 PAS domain; Region: PAS_9; pfam13426 693970004261 putative active site [active] 693970004262 heme pocket [chemical binding]; other site 693970004263 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970004264 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970004265 metal binding site [ion binding]; metal-binding site 693970004266 active site 693970004267 I-site; other site 693970004268 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970004269 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693970004270 DEAD-like helicases superfamily; Region: DEXDc; smart00487 693970004271 ATP binding site [chemical binding]; other site 693970004272 Mg++ binding site [ion binding]; other site 693970004273 motif III; other site 693970004274 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970004275 nucleotide binding region [chemical binding]; other site 693970004276 ATP-binding site [chemical binding]; other site 693970004277 Integrase core domain; Region: rve; pfam00665 693970004278 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970004279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970004280 Walker A motif; other site 693970004281 ATP binding site [chemical binding]; other site 693970004282 Walker B motif; other site 693970004283 Transposase; Region: HTH_Tnp_1; cl17663 693970004284 Winged helix-turn helix; Region: HTH_29; pfam13551 693970004285 Homeodomain-like domain; Region: HTH_32; pfam13565 693970004286 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970004287 Integrase core domain; Region: rve; pfam00665 693970004288 Integrase core domain; Region: rve_3; pfam13683 693970004289 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 693970004290 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 693970004291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970004292 non-specific DNA binding site [nucleotide binding]; other site 693970004293 salt bridge; other site 693970004294 sequence-specific DNA binding site [nucleotide binding]; other site 693970004295 Winged helix-turn helix; Region: HTH_29; pfam13551 693970004296 Homeodomain-like domain; Region: HTH_32; pfam13565 693970004297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970004298 Integrase core domain; Region: rve; pfam00665 693970004299 Integrase core domain; Region: rve_3; pfam13683 693970004300 Transposase; Region: HTH_Tnp_1; cl17663 693970004301 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 693970004302 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970004303 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970004304 Integrase core domain; Region: rve; pfam00665 693970004305 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970004306 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970004307 Integrase core domain; Region: rve; pfam00665 693970004308 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 693970004309 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 693970004310 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 693970004311 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 693970004312 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 693970004313 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 693970004314 Phage-related protein [Function unknown]; Region: COG4695; cl01923 693970004315 Phage portal protein; Region: Phage_portal; pfam04860 693970004316 terminase ATPase subunit; Provisional; Region: P; PHA02535 693970004317 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 693970004318 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 693970004319 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 693970004320 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 693970004321 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 693970004322 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 693970004323 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 693970004324 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 693970004325 Protein of unknown function (DUF2597); Region: DUF2597; pfam10772 693970004326 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 693970004327 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 693970004328 catalytic residues [active] 693970004329 Protein of unknown function (DUF2765); Region: DUF2765; pfam10963 693970004330 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 693970004331 Protein of unknown function (DUF2590); Region: DUF2590; pfam10761 693970004332 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 693970004333 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 693970004334 SmpB-tmRNA interface; other site 693970004335 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 693970004336 putative coenzyme Q binding site [chemical binding]; other site 693970004337 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 693970004338 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 693970004339 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 693970004340 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 693970004341 active site 693970004342 SAM binding site [chemical binding]; other site 693970004343 homodimer interface [polypeptide binding]; other site 693970004344 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 693970004345 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970004346 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970004347 metal binding site [ion binding]; metal-binding site 693970004348 active site 693970004349 I-site; other site 693970004350 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 693970004351 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 693970004352 TrkA-N domain; Region: TrkA_N; pfam02254 693970004353 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693970004354 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970004355 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970004356 malate synthase A; Region: malate_syn_A; TIGR01344 693970004357 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 693970004358 active site 693970004359 isocitrate lyase; Provisional; Region: PRK15063 693970004360 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 693970004361 tetramer interface [polypeptide binding]; other site 693970004362 active site 693970004363 Mg2+/Mn2+ binding site [ion binding]; other site 693970004364 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 693970004365 putative alcohol dehydrogenase; Provisional; Region: PRK09860 693970004366 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 693970004367 dimer interface [polypeptide binding]; other site 693970004368 active site 693970004369 metal binding site [ion binding]; metal-binding site 693970004370 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970004371 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970004372 Integrase core domain; Region: rve; pfam00665 693970004373 transcriptional regulator BetI; Validated; Region: PRK00767 693970004374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693970004375 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 693970004376 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 693970004377 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 693970004378 NAD(P) binding site [chemical binding]; other site 693970004379 catalytic residues [active] 693970004380 choline dehydrogenase; Validated; Region: PRK02106 693970004381 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 693970004382 BCCT family transporter; Region: BCCT; cl00569 693970004383 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 693970004384 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693970004385 MarR family; Region: MarR; pfam01047 693970004386 MarR family; Region: MarR_2; cl17246 693970004387 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 693970004388 active site 693970004389 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 693970004390 glycogen branching enzyme; Provisional; Region: PRK05402 693970004391 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 693970004392 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 693970004393 active site 693970004394 catalytic site [active] 693970004395 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 693970004396 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 693970004397 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 693970004398 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 693970004399 active site 693970004400 catalytic site [active] 693970004401 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 693970004402 homodimer interface [polypeptide binding]; other site 693970004403 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 693970004404 active site pocket [active] 693970004405 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 693970004406 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 693970004407 ligand binding site; other site 693970004408 oligomer interface; other site 693970004409 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 693970004410 dimer interface [polypeptide binding]; other site 693970004411 N-terminal domain interface [polypeptide binding]; other site 693970004412 sulfate 1 binding site; other site 693970004413 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 693970004414 glycogen synthase; Provisional; Region: glgA; PRK00654 693970004415 ADP-binding pocket [chemical binding]; other site 693970004416 homodimer interface [polypeptide binding]; other site 693970004417 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 693970004418 PAS domain S-box; Region: sensory_box; TIGR00229 693970004419 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970004420 putative active site [active] 693970004421 heme pocket [chemical binding]; other site 693970004422 PAS fold; Region: PAS_3; pfam08447 693970004423 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970004424 PAS domain; Region: PAS_9; pfam13426 693970004425 putative active site [active] 693970004426 heme pocket [chemical binding]; other site 693970004427 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970004428 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970004429 metal binding site [ion binding]; metal-binding site 693970004430 active site 693970004431 I-site; other site 693970004432 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970004433 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 693970004434 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693970004435 ATP binding site [chemical binding]; other site 693970004436 Mg++ binding site [ion binding]; other site 693970004437 motif III; other site 693970004438 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970004439 nucleotide binding region [chemical binding]; other site 693970004440 ATP-binding site [chemical binding]; other site 693970004441 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 693970004442 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 693970004443 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 693970004444 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693970004445 substrate binding pocket [chemical binding]; other site 693970004446 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693970004447 membrane-bound complex binding site; other site 693970004448 hinge residues; other site 693970004449 Protein of unknown function (DUF3087); Region: DUF3087; pfam11286 693970004450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970004451 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693970004452 putative substrate translocation pore; other site 693970004453 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 693970004454 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 693970004455 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 693970004456 dimer interface [polypeptide binding]; other site 693970004457 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693970004458 ligand binding site [chemical binding]; other site 693970004459 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970004460 Transposase; Region: HTH_Tnp_1; pfam01527 693970004461 putative transposase OrfB; Reviewed; Region: PHA02517 693970004462 HTH-like domain; Region: HTH_21; pfam13276 693970004463 Integrase core domain; Region: rve; pfam00665 693970004464 Integrase core domain; Region: rve_3; pfam13683 693970004465 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 693970004466 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 693970004467 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 693970004468 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693970004469 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 693970004470 Cysteine-rich domain; Region: CCG; pfam02754 693970004471 Cysteine-rich domain; Region: CCG; pfam02754 693970004472 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 693970004473 FAD binding domain; Region: FAD_binding_4; pfam01565 693970004474 4Fe-4S binding domain; Region: Fer4; pfam00037 693970004475 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 693970004476 L-lactate permease; Region: Lactate_perm; cl00701 693970004477 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 693970004478 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 693970004479 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 693970004480 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 693970004481 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 693970004482 dimer interface [polypeptide binding]; other site 693970004483 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 693970004484 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 693970004485 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 693970004486 TPP-binding site; other site 693970004487 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693970004488 PYR/PP interface [polypeptide binding]; other site 693970004489 dimer interface [polypeptide binding]; other site 693970004490 TPP binding site [chemical binding]; other site 693970004491 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693970004492 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 693970004493 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 693970004494 substrate binding pocket [chemical binding]; other site 693970004495 chain length determination region; other site 693970004496 substrate-Mg2+ binding site; other site 693970004497 catalytic residues [active] 693970004498 aspartate-rich region 1; other site 693970004499 active site lid residues [active] 693970004500 aspartate-rich region 2; other site 693970004501 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 693970004502 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 693970004503 flagellar motor protein PomA; Reviewed; Region: PRK08990 693970004504 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 693970004505 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 693970004506 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693970004507 ligand binding site [chemical binding]; other site 693970004508 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 693970004509 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 693970004510 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 693970004511 Ligand Binding Site [chemical binding]; other site 693970004512 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 693970004513 active site residue [active] 693970004514 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693970004515 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970004516 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 693970004517 dimerization interface [polypeptide binding]; other site 693970004518 substrate binding pocket [chemical binding]; other site 693970004519 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 693970004520 Protein of unknown function (DUF423); Region: DUF423; pfam04241 693970004521 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 693970004522 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 693970004523 isocitrate dehydrogenase; Provisional; Region: PRK08997 693970004524 tartrate dehydrogenase; Region: TTC; TIGR02089 693970004525 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 693970004526 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693970004527 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 693970004528 flap endonuclease-like protein; Provisional; Region: PRK09482 693970004529 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 693970004530 active site 693970004531 metal binding site 1 [ion binding]; metal-binding site 693970004532 putative 5' ssDNA interaction site; other site 693970004533 metal binding site 3; metal-binding site 693970004534 metal binding site 2 [ion binding]; metal-binding site 693970004535 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 693970004536 putative DNA binding site [nucleotide binding]; other site 693970004537 putative metal binding site [ion binding]; other site 693970004538 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 693970004539 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 693970004540 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970004541 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970004542 metal binding site [ion binding]; metal-binding site 693970004543 active site 693970004544 I-site; other site 693970004545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970004546 TPR motif; other site 693970004547 binding surface 693970004548 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693970004549 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693970004550 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 693970004551 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 693970004552 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 693970004553 protein binding site [polypeptide binding]; other site 693970004554 recombination associated protein; Reviewed; Region: rdgC; PRK00321 693970004555 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693970004556 trimer interface [polypeptide binding]; other site 693970004557 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693970004558 eyelet of channel; other site 693970004559 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 693970004560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970004561 active site 693970004562 phosphorylation site [posttranslational modification] 693970004563 intermolecular recognition site; other site 693970004564 dimerization interface [polypeptide binding]; other site 693970004565 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693970004566 DNA binding site [nucleotide binding] 693970004567 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 693970004568 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 693970004569 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970004570 putative active site [active] 693970004571 heme pocket [chemical binding]; other site 693970004572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970004573 dimer interface [polypeptide binding]; other site 693970004574 phosphorylation site [posttranslational modification] 693970004575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970004576 ATP binding site [chemical binding]; other site 693970004577 Mg2+ binding site [ion binding]; other site 693970004578 G-X-G motif; other site 693970004579 PBP superfamily domain; Region: PBP_like_2; cl17296 693970004580 putative transposase OrfB; Reviewed; Region: PHA02517 693970004581 Integrase core domain; Region: rve; pfam00665 693970004582 Integrase core domain; Region: rve_3; pfam13683 693970004583 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 693970004584 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 693970004585 active site 693970004586 Zn binding site [ion binding]; other site 693970004587 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 693970004588 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 693970004589 catalytic residues [active] 693970004590 dimer interface [polypeptide binding]; other site 693970004591 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 693970004592 MgtE intracellular N domain; Region: MgtE_N; smart00924 693970004593 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 693970004594 Divalent cation transporter; Region: MgtE; cl00786 693970004595 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693970004596 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970004597 Coenzyme A binding pocket [chemical binding]; other site 693970004598 YfaZ precursor; Region: YfaZ; pfam07437 693970004599 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 693970004600 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693970004601 EamA-like transporter family; Region: EamA; pfam00892 693970004602 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 693970004603 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 693970004604 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970004605 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970004606 metal binding site [ion binding]; metal-binding site 693970004607 active site 693970004608 I-site; other site 693970004609 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 693970004610 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693970004611 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 693970004612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970004613 S-adenosylmethionine binding site [chemical binding]; other site 693970004614 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 693970004615 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 693970004616 C-terminal domain interface [polypeptide binding]; other site 693970004617 GSH binding site (G-site) [chemical binding]; other site 693970004618 dimer interface [polypeptide binding]; other site 693970004619 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 693970004620 N-terminal domain interface [polypeptide binding]; other site 693970004621 putative dimer interface [polypeptide binding]; other site 693970004622 active site 693970004623 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693970004624 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 693970004625 putative C-terminal domain interface [polypeptide binding]; other site 693970004626 putative GSH binding site (G-site) [chemical binding]; other site 693970004627 putative dimer interface [polypeptide binding]; other site 693970004628 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 693970004629 putative N-terminal domain interface [polypeptide binding]; other site 693970004630 putative dimer interface [polypeptide binding]; other site 693970004631 putative substrate binding pocket (H-site) [chemical binding]; other site 693970004632 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693970004633 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693970004634 TIGR02453 family protein; Region: TIGR02453 693970004635 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 693970004636 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693970004637 N-terminal plug; other site 693970004638 ligand-binding site [chemical binding]; other site 693970004639 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 693970004640 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 693970004641 PhnA protein; Region: PhnA; pfam03831 693970004642 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 693970004643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970004644 putative substrate translocation pore; other site 693970004645 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693970004646 MarR family; Region: MarR; pfam01047 693970004647 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 693970004648 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 693970004649 putative active site [active] 693970004650 Zn binding site [ion binding]; other site 693970004651 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970004652 dimerization interface [polypeptide binding]; other site 693970004653 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693970004654 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970004655 dimer interface [polypeptide binding]; other site 693970004656 putative CheW interface [polypeptide binding]; other site 693970004657 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 693970004658 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 693970004659 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 693970004660 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 693970004661 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 693970004662 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 693970004663 active site 693970004664 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 693970004665 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693970004666 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693970004667 nucleotide binding site [chemical binding]; other site 693970004668 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 693970004669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970004670 putative substrate translocation pore; other site 693970004671 L-fucose transporter; Provisional; Region: PRK10133; cl17665 693970004672 Helix-turn-helix domain; Region: HTH_18; pfam12833 693970004673 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 693970004674 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 693970004675 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970004676 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693970004677 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 693970004678 Putative catalytic NodB homology domain of uncharacterized Mll8295 protein encoded from Rhizobium loti and its bacterial homologs; Region: CE4_Mll8295_like; cd10946 693970004679 NodB motif; other site 693970004680 putative active site [active] 693970004681 putative catalytic site [active] 693970004682 putative Zn binding site [ion binding]; other site 693970004683 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 693970004684 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 693970004685 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 693970004686 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693970004687 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 693970004688 BON domain; Region: BON; pfam04972 693970004689 BON domain; Region: BON; pfam04972 693970004690 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 693970004691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970004692 Walker A motif; other site 693970004693 ATP binding site [chemical binding]; other site 693970004694 Walker B motif; other site 693970004695 arginine finger; other site 693970004696 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693970004697 Major royal jelly protein; Region: MRJP; pfam03022 693970004698 hypothetical protein; Provisional; Region: PRK12361 693970004699 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 693970004700 active site 693970004701 catalytic residues [active] 693970004702 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 693970004703 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 693970004704 FMN binding site [chemical binding]; other site 693970004705 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 693970004706 substrate binding site [chemical binding]; other site 693970004707 putative catalytic residue [active] 693970004708 3-oxoacyl-[acyl-carrier-protein] synthase; Region: PLN02836 693970004709 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 693970004710 active site 693970004711 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 693970004712 active site 693970004713 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 693970004714 active site 2 [active] 693970004715 dimer interface [polypeptide binding]; other site 693970004716 active site 1 [active] 693970004717 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 693970004718 active site 1 [active] 693970004719 dimer interface [polypeptide binding]; other site 693970004720 active site 2 [active] 693970004721 Acyl transferase domain; Region: Acyl_transf_1; cl08282 693970004722 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 693970004723 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 693970004724 active site 693970004725 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 693970004726 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 693970004727 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 693970004728 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 693970004729 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 693970004730 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 693970004731 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 693970004732 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 693970004733 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 693970004734 putative NADP binding site [chemical binding]; other site 693970004735 active site 693970004736 Winged helix-turn helix; Region: HTH_29; pfam13551 693970004737 Helix-turn-helix domain; Region: HTH_17; pfam12728 693970004738 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 693970004739 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 693970004740 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 693970004741 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693970004742 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 693970004743 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970004744 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 693970004745 putative substrate binding pocket [chemical binding]; other site 693970004746 putative dimerization interface [polypeptide binding]; other site 693970004747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 693970004748 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 693970004749 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 693970004750 SecY interacting protein Syd; Provisional; Region: PRK04968 693970004751 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; pfam10071 693970004752 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 693970004753 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 693970004754 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 693970004755 Coenzyme A binding pocket [chemical binding]; other site 693970004756 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 693970004757 Protein of unknown function (DUF3549); Region: DUF3549; pfam12069 693970004758 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 693970004759 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693970004760 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 693970004761 probable active site [active] 693970004762 flavodoxin; Provisional; Region: PRK08105 693970004763 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 693970004764 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693970004765 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693970004766 active site turn [active] 693970004767 phosphorylation site [posttranslational modification] 693970004768 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 693970004769 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 693970004770 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 693970004771 putative active site [active] 693970004772 putative substrate binding site [chemical binding]; other site 693970004773 putative cosubstrate binding site; other site 693970004774 catalytic site [active] 693970004775 PAS domain; Region: PAS_9; pfam13426 693970004776 GAF domain; Region: GAF_2; pfam13185 693970004777 GAF domain; Region: GAF; pfam01590 693970004778 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 693970004779 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693970004780 Zn2+ binding site [ion binding]; other site 693970004781 Mg2+ binding site [ion binding]; other site 693970004782 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 693970004783 FOG: CBS domain [General function prediction only]; Region: COG0517 693970004784 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 693970004785 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 693970004786 trimer interface [polypeptide binding]; other site 693970004787 active site 693970004788 substrate binding site [chemical binding]; other site 693970004789 CoA binding site [chemical binding]; other site 693970004790 PII uridylyl-transferase; Provisional; Region: PRK05007 693970004791 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 693970004792 metal binding triad; other site 693970004793 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 693970004794 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 693970004795 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 693970004796 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 693970004797 active site 693970004798 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 693970004799 rRNA interaction site [nucleotide binding]; other site 693970004800 S8 interaction site; other site 693970004801 putative laminin-1 binding site; other site 693970004802 elongation factor Ts; Provisional; Region: tsf; PRK09377 693970004803 UBA/TS-N domain; Region: UBA; pfam00627 693970004804 Elongation factor TS; Region: EF_TS; pfam00889 693970004805 Elongation factor TS; Region: EF_TS; pfam00889 693970004806 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 693970004807 putative nucleotide binding site [chemical binding]; other site 693970004808 uridine monophosphate binding site [chemical binding]; other site 693970004809 homohexameric interface [polypeptide binding]; other site 693970004810 ribosome recycling factor; Reviewed; Region: frr; PRK00083 693970004811 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 693970004812 hinge region; other site 693970004813 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 693970004814 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 693970004815 catalytic residue [active] 693970004816 putative FPP diphosphate binding site; other site 693970004817 putative FPP binding hydrophobic cleft; other site 693970004818 dimer interface [polypeptide binding]; other site 693970004819 putative IPP diphosphate binding site; other site 693970004820 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 693970004821 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 693970004822 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 693970004823 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 693970004824 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 693970004825 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 693970004826 zinc metallopeptidase RseP; Provisional; Region: PRK10779 693970004827 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 693970004828 active site 693970004829 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 693970004830 protein binding site [polypeptide binding]; other site 693970004831 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 693970004832 protein binding site [polypeptide binding]; other site 693970004833 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 693970004834 putative substrate binding region [chemical binding]; other site 693970004835 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 693970004836 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693970004837 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693970004838 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693970004839 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693970004840 Surface antigen; Region: Bac_surface_Ag; pfam01103 693970004841 periplasmic chaperone; Provisional; Region: PRK10780 693970004842 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 693970004843 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 693970004844 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 693970004845 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 693970004846 trimer interface [polypeptide binding]; other site 693970004847 active site 693970004848 UDP-GlcNAc binding site [chemical binding]; other site 693970004849 lipid binding site [chemical binding]; lipid-binding site 693970004850 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 693970004851 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 693970004852 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 693970004853 active site 693970004854 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 693970004855 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 693970004856 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 693970004857 RNA/DNA hybrid binding site [nucleotide binding]; other site 693970004858 active site 693970004859 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 693970004860 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 693970004861 putative active site [active] 693970004862 putative PHP Thumb interface [polypeptide binding]; other site 693970004863 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 693970004864 generic binding surface II; other site 693970004865 generic binding surface I; other site 693970004866 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 693970004867 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 693970004868 Ligand Binding Site [chemical binding]; other site 693970004869 TilS substrate binding domain; Region: TilS; pfam09179 693970004870 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 693970004871 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970004872 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970004873 metal binding site [ion binding]; metal-binding site 693970004874 active site 693970004875 I-site; other site 693970004876 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 693970004877 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 693970004878 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 693970004879 TrkA-N domain; Region: TrkA_N; pfam02254 693970004880 TrkA-C domain; Region: TrkA_C; pfam02080 693970004881 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693970004882 DNA-binding site [nucleotide binding]; DNA binding site 693970004883 RNA-binding motif; other site 693970004884 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 693970004885 SWIM zinc finger; Region: SWIM; pfam04434 693970004886 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 693970004887 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693970004888 ATP binding site [chemical binding]; other site 693970004889 putative Mg++ binding site [ion binding]; other site 693970004890 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970004891 nucleotide binding region [chemical binding]; other site 693970004892 ATP-binding site [chemical binding]; other site 693970004893 putative hydrolase; Validated; Region: PRK09248 693970004894 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 693970004895 active site 693970004896 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 693970004897 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 693970004898 NADP binding site [chemical binding]; other site 693970004899 active site 693970004900 putative substrate binding site [chemical binding]; other site 693970004901 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 693970004902 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 693970004903 active site 693970004904 fructokinase; Reviewed; Region: PRK09557 693970004905 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693970004906 nucleotide binding site [chemical binding]; other site 693970004907 Uncharacterized conserved protein [Function unknown]; Region: COG1434 693970004908 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 693970004909 putative active site [active] 693970004910 Protein of unknown function (DUF2982); Region: DUF2982; pfam11201 693970004911 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 693970004912 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970004913 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970004914 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693970004915 dimerization interface [polypeptide binding]; other site 693970004916 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 693970004917 ferredoxin-type protein; Provisional; Region: PRK10194 693970004918 4Fe-4S binding domain; Region: Fer4; cl02805 693970004919 UDP-glucose 4-epimerase; Region: PLN02240 693970004920 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 693970004921 NAD binding site [chemical binding]; other site 693970004922 homodimer interface [polypeptide binding]; other site 693970004923 active site 693970004924 substrate binding site [chemical binding]; other site 693970004925 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 693970004926 active site 693970004927 tetramer interface; other site 693970004928 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 693970004929 cofactor binding site; other site 693970004930 metal binding site [ion binding]; metal-binding site 693970004931 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 693970004932 aromatic arch; other site 693970004933 DCoH dimer interaction site [polypeptide binding]; other site 693970004934 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 693970004935 DCoH tetramer interaction site [polypeptide binding]; other site 693970004936 substrate binding site [chemical binding]; other site 693970004937 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 693970004938 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 693970004939 putative aromatic amino acid binding site; other site 693970004940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970004941 Walker A motif; other site 693970004942 ATP binding site [chemical binding]; other site 693970004943 Walker B motif; other site 693970004944 arginine finger; other site 693970004945 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 693970004946 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 693970004947 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 693970004948 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 693970004949 maleylacetoacetate isomerase; Region: maiA; TIGR01262 693970004950 C-terminal domain interface [polypeptide binding]; other site 693970004951 GSH binding site (G-site) [chemical binding]; other site 693970004952 putative dimer interface [polypeptide binding]; other site 693970004953 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 693970004954 dimer interface [polypeptide binding]; other site 693970004955 N-terminal domain interface [polypeptide binding]; other site 693970004956 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 693970004957 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 693970004958 outer membrane protein W; Provisional; Region: PRK10959 693970004959 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 693970004960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693970004961 NAD(P) binding site [chemical binding]; other site 693970004962 active site 693970004963 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 693970004964 homoserine O-succinyltransferase; Provisional; Region: PRK05368 693970004965 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 693970004966 proposed active site lysine [active] 693970004967 conserved cys residue [active] 693970004968 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 693970004969 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693970004970 HAMP domain; Region: HAMP; pfam00672 693970004971 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970004972 dimer interface [polypeptide binding]; other site 693970004973 putative CheW interface [polypeptide binding]; other site 693970004974 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 693970004975 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693970004976 dimer interface [polypeptide binding]; other site 693970004977 active site 693970004978 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 693970004979 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 693970004980 tetrameric interface [polypeptide binding]; other site 693970004981 NAD binding site [chemical binding]; other site 693970004982 catalytic residues [active] 693970004983 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693970004984 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693970004985 active site 693970004986 enoyl-CoA hydratase; Provisional; Region: PRK09076 693970004987 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693970004988 substrate binding site [chemical binding]; other site 693970004989 oxyanion hole (OAH) forming residues; other site 693970004990 trimer interface [polypeptide binding]; other site 693970004991 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 693970004992 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693970004993 substrate binding site [chemical binding]; other site 693970004994 oxyanion hole (OAH) forming residues; other site 693970004995 trimer interface [polypeptide binding]; other site 693970004996 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 693970004997 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 693970004998 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 693970004999 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 693970005000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693970005001 NAD(P) binding site [chemical binding]; other site 693970005002 active site 693970005003 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 693970005004 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693970005005 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 693970005006 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 693970005007 DNA binding residues [nucleotide binding] 693970005008 dimer interface [polypeptide binding]; other site 693970005009 copper binding site [ion binding]; other site 693970005010 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 693970005011 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693970005012 metal-binding site [ion binding] 693970005013 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693970005014 Soluble P-type ATPase [General function prediction only]; Region: COG4087 693970005015 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 693970005016 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693970005017 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693970005018 ABC transporter; Region: ABC_tran_2; pfam12848 693970005019 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693970005020 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 693970005021 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 693970005022 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970005023 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970005024 Integrase core domain; Region: rve; pfam00665 693970005025 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 693970005026 PAS domain; Region: PAS_9; pfam13426 693970005027 putative active site [active] 693970005028 heme pocket [chemical binding]; other site 693970005029 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970005030 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970005031 metal binding site [ion binding]; metal-binding site 693970005032 active site 693970005033 I-site; other site 693970005034 Domain of unknown function (DUF1888); Region: DUF1888; pfam08985 693970005035 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693970005036 DNA binding site [nucleotide binding] 693970005037 AAA ATPase domain; Region: AAA_16; pfam13191 693970005038 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693970005039 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693970005040 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693970005041 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 693970005042 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970005043 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693970005044 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693970005045 Walker A/P-loop; other site 693970005046 ATP binding site [chemical binding]; other site 693970005047 Q-loop/lid; other site 693970005048 ABC transporter signature motif; other site 693970005049 Walker B; other site 693970005050 D-loop; other site 693970005051 H-loop/switch region; other site 693970005052 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 693970005053 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 693970005054 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 693970005055 signal peptidase I; Provisional; Region: PRK10861 693970005056 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693970005057 Catalytic site [active] 693970005058 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693970005059 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 693970005060 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 693970005061 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 693970005062 SseB protein; Region: SseB; cl06279 693970005063 Beta-lactamase; Region: Beta-lactamase; pfam00144 693970005064 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 693970005065 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970005066 Coenzyme A binding pocket [chemical binding]; other site 693970005067 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 693970005068 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693970005069 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 693970005070 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 693970005071 EamA-like transporter family; Region: EamA; pfam00892 693970005072 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693970005073 EamA-like transporter family; Region: EamA; pfam00892 693970005074 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 693970005075 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 693970005076 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 693970005077 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 693970005078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693970005079 conserved gate region; other site 693970005080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693970005081 ABC-ATPase subunit interface; other site 693970005082 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 693970005083 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 693970005084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693970005085 dimer interface [polypeptide binding]; other site 693970005086 conserved gate region; other site 693970005087 putative PBP binding loops; other site 693970005088 ABC-ATPase subunit interface; other site 693970005089 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 693970005090 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 693970005091 Walker A/P-loop; other site 693970005092 ATP binding site [chemical binding]; other site 693970005093 Q-loop/lid; other site 693970005094 ABC transporter signature motif; other site 693970005095 Walker B; other site 693970005096 D-loop; other site 693970005097 H-loop/switch region; other site 693970005098 transcriptional regulator PhoU; Provisional; Region: PRK11115 693970005099 PhoU domain; Region: PhoU; pfam01895 693970005100 PhoU domain; Region: PhoU; pfam01895 693970005101 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 693970005102 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 693970005103 dimer interface [polypeptide binding]; other site 693970005104 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693970005105 metal binding site [ion binding]; metal-binding site 693970005106 Protein of unknown function (DUF502); Region: DUF502; pfam04367 693970005107 BCCT family transporter; Region: BCCT; pfam02028 693970005108 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 693970005109 active site 693970005110 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 693970005111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970005112 S-adenosylmethionine binding site [chemical binding]; other site 693970005113 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 693970005114 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 693970005115 dimer interface [polypeptide binding]; other site 693970005116 active site 693970005117 CoA binding pocket [chemical binding]; other site 693970005118 haloalkane dehalogenase; Provisional; Region: PRK03592 693970005119 peptide synthase; Provisional; Region: PRK09274 693970005120 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693970005121 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 693970005122 acyl-activating enzyme (AAE) consensus motif; other site 693970005123 putative AMP binding site [chemical binding]; other site 693970005124 putative active site [active] 693970005125 putative CoA binding site [chemical binding]; other site 693970005126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693970005127 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 693970005128 NAD(P) binding site [chemical binding]; other site 693970005129 active site 693970005130 Protein of unknown function (DUF3624); Region: DUF3624; pfam12292 693970005131 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 693970005132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970005133 putative substrate translocation pore; other site 693970005134 POT family; Region: PTR2; cl17359 693970005135 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 693970005136 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 693970005137 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 693970005138 Walker A/P-loop; other site 693970005139 ATP binding site [chemical binding]; other site 693970005140 Q-loop/lid; other site 693970005141 ABC transporter signature motif; other site 693970005142 Walker B; other site 693970005143 D-loop; other site 693970005144 H-loop/switch region; other site 693970005145 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 693970005146 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 693970005147 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 693970005148 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 693970005149 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 693970005150 Zn binding site [ion binding]; other site 693970005151 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 693970005152 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 693970005153 active site 693970005154 substrate binding site [chemical binding]; other site 693970005155 metal binding site [ion binding]; metal-binding site 693970005156 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 693970005157 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693970005158 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 693970005159 Predicted transcriptional regulator [Transcription]; Region: COG2378 693970005160 HTH domain; Region: HTH_11; pfam08279 693970005161 WYL domain; Region: WYL; pfam13280 693970005162 Aerolysin toxin; Region: Aerolysin; smart00999 693970005163 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 693970005164 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 693970005165 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693970005166 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693970005167 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693970005168 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693970005169 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 693970005170 trimer interface [polypeptide binding]; other site 693970005171 active site 693970005172 substrate binding site [chemical binding]; other site 693970005173 CoA binding site [chemical binding]; other site 693970005174 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970005175 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970005176 Integrase core domain; Region: rve; pfam00665 693970005177 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 693970005178 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 693970005179 putative pyridoxal-dependent aspartate 1-decarboxylase; Region: NOD_PanD_pyr; TIGR03799 693970005180 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693970005181 catalytic residue [active] 693970005182 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 693970005183 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 693970005184 fructuronate transporter; Provisional; Region: PRK10034; cl15264 693970005185 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 693970005186 putative heme binding pocket [chemical binding]; other site 693970005187 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970005188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970005189 Walker A motif; other site 693970005190 ATP binding site [chemical binding]; other site 693970005191 Walker B motif; other site 693970005192 Integrase core domain; Region: rve; pfam00665 693970005193 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 693970005194 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 693970005195 DNA methylase; Region: N6_N4_Mtase; pfam01555 693970005196 DNA methylase; Region: N6_N4_Mtase; pfam01555 693970005197 mobile mystery protein B; Region: mob_myst_B; TIGR02613 693970005198 Fic/DOC family; Region: Fic; pfam02661 693970005199 mobile mystery protein A; Region: mob_myst_A; TIGR02612 693970005200 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970005201 non-specific DNA binding site [nucleotide binding]; other site 693970005202 salt bridge; other site 693970005203 sequence-specific DNA binding site [nucleotide binding]; other site 693970005204 Integrase core domain; Region: rve; pfam00665 693970005205 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970005206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970005207 Walker A motif; other site 693970005208 ATP binding site [chemical binding]; other site 693970005209 Walker B motif; other site 693970005210 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693970005211 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 693970005212 active site 693970005213 DNA binding site [nucleotide binding] 693970005214 Int/Topo IB signature motif; other site 693970005215 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 693970005216 ligand binding site [chemical binding]; other site 693970005217 active site 693970005218 Protein of unknown function (DUF3374); Region: DUF3374; pfam11854 693970005219 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 693970005220 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 693970005221 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 693970005222 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 693970005223 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 693970005224 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 693970005225 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 693970005226 heme-binding residues [chemical binding]; other site 693970005227 Protein of unknown function (DUF3374); Region: DUF3374; pfam11854 693970005228 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 693970005229 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 693970005230 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 693970005231 FeoA domain; Region: FeoA; pfam04023 693970005232 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 693970005233 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 693970005234 G1 box; other site 693970005235 GTP/Mg2+ binding site [chemical binding]; other site 693970005236 Switch I region; other site 693970005237 G2 box; other site 693970005238 G3 box; other site 693970005239 Switch II region; other site 693970005240 G4 box; other site 693970005241 G5 box; other site 693970005242 Nucleoside recognition; Region: Gate; pfam07670 693970005243 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 693970005244 Nucleoside recognition; Region: Gate; pfam07670 693970005245 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 693970005246 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693970005247 active site 693970005248 HIGH motif; other site 693970005249 nucleotide binding site [chemical binding]; other site 693970005250 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 693970005251 KMSKS motif; other site 693970005252 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 693970005253 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 693970005254 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 693970005255 active site 693970005256 dinuclear metal binding site [ion binding]; other site 693970005257 dimerization interface [polypeptide binding]; other site 693970005258 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693970005259 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 693970005260 putative active site [active] 693970005261 putative metal binding site [ion binding]; other site 693970005262 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 693970005263 substrate binding site [chemical binding]; other site 693970005264 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 693970005265 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 693970005266 active site 693970005267 HIGH motif; other site 693970005268 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 693970005269 KMSKS motif; other site 693970005270 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 693970005271 tRNA binding surface [nucleotide binding]; other site 693970005272 anticodon binding site; other site 693970005273 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 693970005274 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 693970005275 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 693970005276 homodimer interface [polypeptide binding]; other site 693970005277 NADP binding site [chemical binding]; other site 693970005278 substrate binding site [chemical binding]; other site 693970005279 trigger factor; Provisional; Region: tig; PRK01490 693970005280 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693970005281 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 693970005282 Clp protease; Region: CLP_protease; pfam00574 693970005283 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 693970005284 oligomer interface [polypeptide binding]; other site 693970005285 active site residues [active] 693970005286 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 693970005287 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 693970005288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970005289 Walker A motif; other site 693970005290 ATP binding site [chemical binding]; other site 693970005291 Walker B motif; other site 693970005292 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 693970005293 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 693970005294 Found in ATP-dependent protease La (LON); Region: LON; smart00464 693970005295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970005296 Walker A motif; other site 693970005297 ATP binding site [chemical binding]; other site 693970005298 Walker B motif; other site 693970005299 arginine finger; other site 693970005300 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 693970005301 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693970005302 IHF dimer interface [polypeptide binding]; other site 693970005303 IHF - DNA interface [nucleotide binding]; other site 693970005304 periplasmic folding chaperone; Provisional; Region: PRK10788 693970005305 SurA N-terminal domain; Region: SurA_N_3; cl07813 693970005306 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 693970005307 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 693970005308 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 693970005309 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 693970005310 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 693970005311 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 693970005312 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167 693970005313 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693970005314 Walker A/P-loop; other site 693970005315 ATP binding site [chemical binding]; other site 693970005316 Q-loop/lid; other site 693970005317 ABC transporter signature motif; other site 693970005318 Walker B; other site 693970005319 D-loop; other site 693970005320 H-loop/switch region; other site 693970005321 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693970005322 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170 693970005323 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693970005324 Walker A/P-loop; other site 693970005325 ATP binding site [chemical binding]; other site 693970005326 Q-loop/lid; other site 693970005327 ABC transporter signature motif; other site 693970005328 Walker B; other site 693970005329 D-loop; other site 693970005330 H-loop/switch region; other site 693970005331 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 693970005332 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 693970005333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693970005334 dimer interface [polypeptide binding]; other site 693970005335 conserved gate region; other site 693970005336 putative PBP binding loops; other site 693970005337 ABC-ATPase subunit interface; other site 693970005338 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693970005339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693970005340 dimer interface [polypeptide binding]; other site 693970005341 conserved gate region; other site 693970005342 putative PBP binding loops; other site 693970005343 ABC-ATPase subunit interface; other site 693970005344 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693970005345 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 693970005346 peptide binding site [polypeptide binding]; other site 693970005347 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 693970005348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970005349 Walker A motif; other site 693970005350 ATP binding site [chemical binding]; other site 693970005351 Walker B motif; other site 693970005352 arginine finger; other site 693970005353 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693970005354 phage shock protein A; Region: phageshock_pspA; TIGR02977 693970005355 phage shock protein B; Provisional; Region: pspB; PRK09458 693970005356 phage shock protein C; Region: phageshock_pspC; TIGR02978 693970005357 PspC domain; Region: PspC; cl00864 693970005358 YcjX-like family, DUF463; Region: DUF463; pfam04317 693970005359 hypothetical protein; Provisional; Region: PRK05415 693970005360 Domain of unknown function (DUF697); Region: DUF697; pfam05128 693970005361 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 693970005362 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693970005363 homodimer interface [polypeptide binding]; other site 693970005364 substrate-cofactor binding pocket; other site 693970005365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970005366 catalytic residue [active] 693970005367 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 693970005368 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 693970005369 Late competence development protein ComFB; Region: ComFB; pfam10719 693970005370 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 693970005371 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 693970005372 putative active site [active] 693970005373 Zn binding site [ion binding]; other site 693970005374 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829 693970005375 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 693970005376 hypothetical protein; Provisional; Region: PRK10621 693970005377 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693970005378 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 693970005379 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 693970005380 Protein of unknown function (DUF570); Region: DUF570; pfam04489 693970005381 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 693970005382 DNA polymerase II; Reviewed; Region: PRK05762 693970005383 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 693970005384 active site 693970005385 catalytic site [active] 693970005386 substrate binding site [chemical binding]; other site 693970005387 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 693970005388 active site 693970005389 metal-binding site 693970005390 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693970005391 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693970005392 trimer interface [polypeptide binding]; other site 693970005393 eyelet of channel; other site 693970005394 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 693970005395 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970005396 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693970005397 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970005398 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970005399 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970005400 Integrase core domain; Region: rve; pfam00665 693970005401 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693970005402 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970005403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970005404 Walker A motif; other site 693970005405 ATP binding site [chemical binding]; other site 693970005406 Walker B motif; other site 693970005407 Integrase core domain; Region: rve; pfam00665 693970005408 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 693970005409 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 693970005410 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 693970005411 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 693970005412 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 693970005413 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 693970005414 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 693970005415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970005416 TPR motif; other site 693970005417 binding surface 693970005418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970005419 binding surface 693970005420 TPR motif; other site 693970005421 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970005422 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970005423 metal binding site [ion binding]; metal-binding site 693970005424 active site 693970005425 I-site; other site 693970005426 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 693970005427 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 693970005428 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693970005429 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693970005430 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693970005431 RNA binding surface [nucleotide binding]; other site 693970005432 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 693970005433 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693970005434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970005435 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 693970005436 dimerization interface [polypeptide binding]; other site 693970005437 substrate binding pocket [chemical binding]; other site 693970005438 hypothetical protein; Provisional; Region: PRK10621 693970005439 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693970005440 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 693970005441 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693970005442 active site 693970005443 metal binding site [ion binding]; metal-binding site 693970005444 DNA binding site [nucleotide binding] 693970005445 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 693970005446 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 693970005447 AAA domain; Region: AAA_23; pfam13476 693970005448 Walker A/P-loop; other site 693970005449 ATP binding site [chemical binding]; other site 693970005450 Q-loop/lid; other site 693970005451 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 693970005452 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 693970005453 ABC transporter signature motif; other site 693970005454 Walker B; other site 693970005455 D-loop; other site 693970005456 H-loop/switch region; other site 693970005457 putative peptidase; Provisional; Region: PRK11649 693970005458 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 693970005459 Peptidase family M23; Region: Peptidase_M23; pfam01551 693970005460 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 693970005461 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 693970005462 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 693970005463 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693970005464 ATP binding site [chemical binding]; other site 693970005465 Mg++ binding site [ion binding]; other site 693970005466 motif III; other site 693970005467 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970005468 nucleotide binding region [chemical binding]; other site 693970005469 ATP-binding site [chemical binding]; other site 693970005470 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 693970005471 active site 693970005472 nucleophile elbow; other site 693970005473 Prostaglandin dehydrogenases; Region: PGDH; cd05288 693970005474 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 693970005475 NAD(P) binding site [chemical binding]; other site 693970005476 substrate binding site [chemical binding]; other site 693970005477 dimer interface [polypeptide binding]; other site 693970005478 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693970005479 MarR family; Region: MarR; pfam01047 693970005480 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 693970005481 ATP cone domain; Region: ATP-cone; pfam03477 693970005482 Class III ribonucleotide reductase; Region: RNR_III; cd01675 693970005483 effector binding site; other site 693970005484 active site 693970005485 Zn binding site [ion binding]; other site 693970005486 glycine loop; other site 693970005487 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121 693970005488 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 693970005489 hypothetical protein; Provisional; Region: PRK11020 693970005490 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 693970005491 dimerization interface [polypeptide binding]; other site 693970005492 active site 693970005493 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 693970005494 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 693970005495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970005496 active site 693970005497 phosphorylation site [posttranslational modification] 693970005498 intermolecular recognition site; other site 693970005499 dimerization interface [polypeptide binding]; other site 693970005500 LytTr DNA-binding domain; Region: LytTR; pfam04397 693970005501 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 693970005502 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 693970005503 GAF domain; Region: GAF_3; pfam13492 693970005504 Histidine kinase; Region: His_kinase; pfam06580 693970005505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970005506 ATP binding site [chemical binding]; other site 693970005507 Mg2+ binding site [ion binding]; other site 693970005508 G-X-G motif; other site 693970005509 Protein of unknown function (DUF2492); Region: DUF2492; pfam10678 693970005510 ParA-like protein; Provisional; Region: PHA02518 693970005511 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693970005512 P-loop; other site 693970005513 Magnesium ion binding site [ion binding]; other site 693970005514 PilZ domain; Region: PilZ; pfam07238 693970005515 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 693970005516 NnrS protein; Region: NnrS; pfam05940 693970005517 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 693970005518 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 693970005519 ComEC family competence protein; Provisional; Region: PRK11539 693970005520 Competence protein; Region: Competence; pfam03772 693970005521 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 693970005522 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 693970005523 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693970005524 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 693970005525 Walker A/P-loop; other site 693970005526 ATP binding site [chemical binding]; other site 693970005527 Q-loop/lid; other site 693970005528 ABC transporter signature motif; other site 693970005529 Walker B; other site 693970005530 D-loop; other site 693970005531 H-loop/switch region; other site 693970005532 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 693970005533 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 693970005534 Uncharacterized conserved protein [Function unknown]; Region: COG2835 693970005535 Predicted membrane protein [Function unknown]; Region: COG3235 693970005536 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 693970005537 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693970005538 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 693970005539 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 693970005540 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 693970005541 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 693970005542 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 693970005543 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693970005544 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 693970005545 cytidine deaminase; Provisional; Region: PRK09027 693970005546 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 693970005547 active site 693970005548 catalytic motif [active] 693970005549 Zn binding site [ion binding]; other site 693970005550 Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211 693970005551 exonuclease I; Provisional; Region: sbcB; PRK11779 693970005552 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 693970005553 active site 693970005554 catalytic site [active] 693970005555 substrate binding site [chemical binding]; other site 693970005556 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 693970005557 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 693970005558 dimer interface [polypeptide binding]; other site 693970005559 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693970005560 ligand binding site [chemical binding]; other site 693970005561 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 693970005562 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693970005563 Omptin family; Region: Omptin; cl01886 693970005564 DinB family; Region: DinB; cl17821 693970005565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970005566 putative substrate translocation pore; other site 693970005567 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693970005568 Predicted transcriptional regulators [Transcription]; Region: COG1733 693970005569 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 693970005570 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 693970005571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970005572 S-adenosylmethionine binding site [chemical binding]; other site 693970005573 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693970005574 DNA-binding site [nucleotide binding]; DNA binding site 693970005575 RNA-binding motif; other site 693970005576 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 693970005577 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 693970005578 Sulfate transporter family; Region: Sulfate_transp; pfam00916 693970005579 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 693970005580 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 693970005581 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 693970005582 homodimer interface [polypeptide binding]; other site 693970005583 oligonucleotide binding site [chemical binding]; other site 693970005584 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 693970005585 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693970005586 RNA binding surface [nucleotide binding]; other site 693970005587 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693970005588 active site 693970005589 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 693970005590 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693970005591 motif II; other site 693970005592 Maf-like protein; Region: Maf; pfam02545 693970005593 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 693970005594 active site 693970005595 dimer interface [polypeptide binding]; other site 693970005596 hypothetical protein; Provisional; Region: PRK11193 693970005597 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 693970005598 putative phosphate acyltransferase; Provisional; Region: PRK05331 693970005599 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 693970005600 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 693970005601 dimer interface [polypeptide binding]; other site 693970005602 active site 693970005603 CoA binding pocket [chemical binding]; other site 693970005604 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 693970005605 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 693970005606 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 693970005607 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 693970005608 NAD(P) binding site [chemical binding]; other site 693970005609 homotetramer interface [polypeptide binding]; other site 693970005610 homodimer interface [polypeptide binding]; other site 693970005611 active site 693970005612 acyl carrier protein; Provisional; Region: acpP; PRK00982 693970005613 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 693970005614 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693970005615 dimer interface [polypeptide binding]; other site 693970005616 active site 693970005617 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 693970005618 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 693970005619 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 693970005620 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 693970005621 active site 693970005622 phosphate binding residues; other site 693970005623 catalytic residues [active] 693970005624 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 693970005625 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 693970005626 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693970005627 active site 693970005628 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 693970005629 Transposase; Region: HTH_Tnp_1; pfam01527 693970005630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970005631 putative transposase OrfB; Reviewed; Region: PHA02517 693970005632 HTH-like domain; Region: HTH_21; pfam13276 693970005633 Integrase core domain; Region: rve; pfam00665 693970005634 Integrase core domain; Region: rve_2; pfam13333 693970005635 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 693970005636 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693970005637 N-terminal plug; other site 693970005638 ligand-binding site [chemical binding]; other site 693970005639 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 693970005640 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 693970005641 active site 693970005642 nucleophile elbow; other site 693970005643 asparagine synthetase B; Provisional; Region: asnB; PRK09431 693970005644 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 693970005645 active site 693970005646 dimer interface [polypeptide binding]; other site 693970005647 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 693970005648 Ligand Binding Site [chemical binding]; other site 693970005649 Molecular Tunnel; other site 693970005650 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 693970005651 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 693970005652 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 693970005653 PA/protease or protease-like domain interface [polypeptide binding]; other site 693970005654 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 693970005655 metal binding site [ion binding]; metal-binding site 693970005656 UMP phosphatase; Provisional; Region: PRK10444 693970005657 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693970005658 active site 693970005659 motif I; other site 693970005660 motif II; other site 693970005661 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693970005662 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 693970005663 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 693970005664 active site 693970005665 substrate binding site [chemical binding]; other site 693970005666 cosubstrate binding site; other site 693970005667 catalytic site [active] 693970005668 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 693970005669 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 693970005670 dimerization interface [polypeptide binding]; other site 693970005671 putative ATP binding site [chemical binding]; other site 693970005672 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693970005673 active site 693970005674 Predicted permease [General function prediction only]; Region: COG2056 693970005675 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 693970005676 peroxidase; Provisional; Region: PRK15000 693970005677 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 693970005678 dimer interface [polypeptide binding]; other site 693970005679 decamer (pentamer of dimers) interface [polypeptide binding]; other site 693970005680 catalytic triad [active] 693970005681 peroxidatic and resolving cysteines [active] 693970005682 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 693970005683 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 693970005684 dimer interface [polypeptide binding]; other site 693970005685 catalytic site [active] 693970005686 putative active site [active] 693970005687 putative substrate binding site [chemical binding]; other site 693970005688 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 693970005689 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693970005690 ligand binding site [chemical binding]; other site 693970005691 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 693970005692 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693970005693 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693970005694 active site 693970005695 TolQ protein; Region: tolQ; TIGR02796 693970005696 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 693970005697 TolR protein; Region: tolR; TIGR02801 693970005698 TolA protein; Region: tolA_full; TIGR02794 693970005699 TolA C-terminal; Region: TolA; pfam06519 693970005700 translocation protein TolB; Provisional; Region: tolB; PRK04792 693970005701 TolB amino-terminal domain; Region: TolB_N; pfam04052 693970005702 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693970005703 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693970005704 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693970005705 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 693970005706 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693970005707 ligand binding site [chemical binding]; other site 693970005708 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 693970005709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970005710 binding surface 693970005711 TPR motif; other site 693970005712 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 693970005713 GSH binding site [chemical binding]; other site 693970005714 catalytic residues [active] 693970005715 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 693970005716 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693970005717 ATP binding site [chemical binding]; other site 693970005718 putative Mg++ binding site [ion binding]; other site 693970005719 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970005720 nucleotide binding region [chemical binding]; other site 693970005721 ATP-binding site [chemical binding]; other site 693970005722 Double zinc ribbon; Region: DZR; pfam12773 693970005723 acetyl-CoA synthetase; Provisional; Region: PRK00174 693970005724 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 693970005725 active site 693970005726 CoA binding site [chemical binding]; other site 693970005727 acyl-activating enzyme (AAE) consensus motif; other site 693970005728 AMP binding site [chemical binding]; other site 693970005729 acetate binding site [chemical binding]; other site 693970005730 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 693970005731 Na binding site [ion binding]; other site 693970005732 PAS domain; Region: PAS; smart00091 693970005733 PAS fold; Region: PAS_7; pfam12860 693970005734 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693970005735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970005736 dimer interface [polypeptide binding]; other site 693970005737 phosphorylation site [posttranslational modification] 693970005738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970005739 ATP binding site [chemical binding]; other site 693970005740 Mg2+ binding site [ion binding]; other site 693970005741 G-X-G motif; other site 693970005742 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693970005743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970005744 active site 693970005745 phosphorylation site [posttranslational modification] 693970005746 intermolecular recognition site; other site 693970005747 dimerization interface [polypeptide binding]; other site 693970005748 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693970005749 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 693970005750 inhibitor-cofactor binding pocket; inhibition site 693970005751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970005752 catalytic residue [active] 693970005753 biotin synthase; Provisional; Region: PRK15108 693970005754 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693970005755 FeS/SAM binding site; other site 693970005756 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 693970005757 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 693970005758 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 693970005759 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693970005760 catalytic residue [active] 693970005761 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 693970005762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970005763 S-adenosylmethionine binding site [chemical binding]; other site 693970005764 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 693970005765 AAA domain; Region: AAA_26; pfam13500 693970005766 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693970005767 IHF - DNA interface [nucleotide binding]; other site 693970005768 IHF dimer interface [polypeptide binding]; other site 693970005769 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693970005770 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970005771 Walker A/P-loop; other site 693970005772 ATP binding site [chemical binding]; other site 693970005773 Q-loop/lid; other site 693970005774 ABC transporter signature motif; other site 693970005775 Walker B; other site 693970005776 D-loop; other site 693970005777 H-loop/switch region; other site 693970005778 hypothetical protein; Provisional; Region: PRK11239 693970005779 Protein of unknown function, DUF480; Region: DUF480; pfam04337 693970005780 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 693970005781 S1 domain; Region: S1_2; pfam13509 693970005782 arginine decarboxylase; Provisional; Region: PRK05354 693970005783 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 693970005784 dimer interface [polypeptide binding]; other site 693970005785 active site 693970005786 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693970005787 catalytic residues [active] 693970005788 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 693970005789 Adenosylmethionine decarboxylase; Region: SAM_decarbox; cl03253 693970005790 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 693970005791 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 693970005792 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 693970005793 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 693970005794 YceI-like domain; Region: YceI; pfam04264 693970005795 Protein of unknown function (DUF3802); Region: DUF3802; pfam12290 693970005796 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 693970005797 Cache domain; Region: Cache_1; pfam02743 693970005798 PAS fold; Region: PAS_4; pfam08448 693970005799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693970005800 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 693970005801 Mg2+ binding site [ion binding]; other site 693970005802 G-X-G motif; other site 693970005803 disulfide bond formation protein B; Provisional; Region: PRK01749 693970005804 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 693970005805 fatty acid metabolism regulator; Provisional; Region: PRK04984 693970005806 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693970005807 DNA-binding site [nucleotide binding]; DNA binding site 693970005808 FadR C-terminal domain; Region: FadR_C; pfam07840 693970005809 SpoVR family protein; Provisional; Region: PRK11767 693970005810 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 693970005811 hypothetical protein; Provisional; Region: PRK05325 693970005812 PrkA family serine protein kinase; Provisional; Region: PRK15455 693970005813 AAA ATPase domain; Region: AAA_16; pfam13191 693970005814 Walker A motif; other site 693970005815 ATP binding site [chemical binding]; other site 693970005816 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 693970005817 superoxide dismutase; Provisional; Region: PRK10543 693970005818 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 693970005819 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 693970005820 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 693970005821 putative GSH binding site [chemical binding]; other site 693970005822 catalytic residues [active] 693970005823 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 693970005824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3249 693970005825 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 693970005826 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 693970005827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970005828 Walker A motif; other site 693970005829 ATP binding site [chemical binding]; other site 693970005830 Walker B motif; other site 693970005831 arginine finger; other site 693970005832 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 693970005833 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 693970005834 ArsC family; Region: ArsC; pfam03960 693970005835 catalytic residues [active] 693970005836 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 693970005837 Peptidase family M48; Region: Peptidase_M48; cl12018 693970005838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970005839 binding surface 693970005840 TPR motif; other site 693970005841 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 693970005842 CPxP motif; other site 693970005843 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 693970005844 Domain of unknown function DUF20; Region: UPF0118; pfam01594 693970005845 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693970005846 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970005847 binding surface 693970005848 TPR motif; other site 693970005849 TPR repeat; Region: TPR_11; pfam13414 693970005850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970005851 binding surface 693970005852 TPR motif; other site 693970005853 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 693970005854 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 693970005855 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693970005856 DNA binding residues [nucleotide binding] 693970005857 dimerization interface [polypeptide binding]; other site 693970005858 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 693970005859 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 693970005860 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693970005861 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 693970005862 nucleotide binding site/active site [active] 693970005863 HIT family signature motif; other site 693970005864 catalytic residue [active] 693970005865 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693970005866 CoenzymeA binding site [chemical binding]; other site 693970005867 subunit interaction site [polypeptide binding]; other site 693970005868 PHB binding site; other site 693970005869 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693970005870 CoenzymeA binding site [chemical binding]; other site 693970005871 subunit interaction site [polypeptide binding]; other site 693970005872 PHB binding site; other site 693970005873 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 693970005874 putative dimer interface [polypeptide binding]; other site 693970005875 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 693970005876 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693970005877 N-terminal plug; other site 693970005878 ligand-binding site [chemical binding]; other site 693970005879 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 693970005880 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 693970005881 Phosphotransferase enzyme family; Region: APH; pfam01636 693970005882 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 693970005883 substrate binding site [chemical binding]; other site 693970005884 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 693970005885 DoxX; Region: DoxX; pfam07681 693970005886 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 693970005887 putative FMN binding site [chemical binding]; other site 693970005888 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693970005889 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693970005890 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 693970005891 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 693970005892 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693970005893 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693970005894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693970005895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970005896 Coenzyme A binding pocket [chemical binding]; other site 693970005897 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693970005898 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693970005899 substrate binding pocket [chemical binding]; other site 693970005900 membrane-bound complex binding site; other site 693970005901 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 693970005902 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 693970005903 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 693970005904 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 693970005905 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 693970005906 generic binding surface II; other site 693970005907 generic binding surface I; other site 693970005908 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 693970005909 putative catalytic site [active] 693970005910 putative metal binding site [ion binding]; other site 693970005911 putative phosphate binding site [ion binding]; other site 693970005912 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 693970005913 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 693970005914 Integrase core domain; Region: rve; pfam00665 693970005915 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970005916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970005917 Walker A motif; other site 693970005918 ATP binding site [chemical binding]; other site 693970005919 Walker B motif; other site 693970005920 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693970005921 HSP70 interaction site [polypeptide binding]; other site 693970005922 exopolyphosphatase; Region: exo_poly_only; TIGR03706 693970005923 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 693970005924 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 693970005925 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 693970005926 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 693970005927 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 693970005928 domain interface [polypeptide binding]; other site 693970005929 active site 693970005930 catalytic site [active] 693970005931 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 693970005932 domain interface [polypeptide binding]; other site 693970005933 active site 693970005934 catalytic site [active] 693970005935 putative chaperone; Provisional; Region: PRK11678 693970005936 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 693970005937 nucleotide binding site [chemical binding]; other site 693970005938 putative NEF/HSP70 interaction site [polypeptide binding]; other site 693970005939 SBD interface [polypeptide binding]; other site 693970005940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 693970005941 CreA protein; Region: CreA; pfam05981 693970005942 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 693970005943 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693970005944 cystathionine beta-lyase; Provisional; Region: PRK09028 693970005945 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 693970005946 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693970005947 catalytic residue [active] 693970005948 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 693970005949 DOMON-like type 9 carbohydrate binding module at the N-terminus of bacterial sensor histidine kinases; Region: CBM9_like_HisKa; cd09622 693970005950 putative ligand binding site [chemical binding]; other site 693970005951 HAMP domain; Region: HAMP; pfam00672 693970005952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970005953 dimer interface [polypeptide binding]; other site 693970005954 phosphorylation site [posttranslational modification] 693970005955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970005956 ATP binding site [chemical binding]; other site 693970005957 Mg2+ binding site [ion binding]; other site 693970005958 G-X-G motif; other site 693970005959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970005960 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 693970005961 active site 693970005962 phosphorylation site [posttranslational modification] 693970005963 intermolecular recognition site; other site 693970005964 dimerization interface [polypeptide binding]; other site 693970005965 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693970005966 DNA binding site [nucleotide binding] 693970005967 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 693970005968 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 693970005969 putative active site [active] 693970005970 putative NTP binding site [chemical binding]; other site 693970005971 putative nucleic acid binding site [nucleotide binding]; other site 693970005972 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 693970005973 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 693970005974 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693970005975 ligand binding site [chemical binding]; other site 693970005976 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 693970005977 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 693970005978 vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461 693970005979 metal ion-dependent adhesion site (MIDAS); other site 693970005980 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 693970005981 active site 693970005982 catalytic site [active] 693970005983 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970005984 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970005985 metal binding site [ion binding]; metal-binding site 693970005986 active site 693970005987 I-site; other site 693970005988 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 693970005989 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 693970005990 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 693970005991 PA/protease or protease-like domain interface [polypeptide binding]; other site 693970005992 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 693970005993 metal binding site [ion binding]; metal-binding site 693970005994 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 693970005995 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693970005996 hypothetical protein; Provisional; Region: PRK11027 693970005997 transcriptional regulator HdfR; Provisional; Region: PRK03601 693970005998 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970005999 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693970006000 dimerization interface [polypeptide binding]; other site 693970006001 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 693970006002 DNA ligase; Provisional; Region: PRK09125 693970006003 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 693970006004 DNA binding site [nucleotide binding] 693970006005 active site 693970006006 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 693970006007 DNA binding site [nucleotide binding] 693970006008 Uncharacterized conserved protein [Function unknown]; Region: COG4748 693970006009 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 693970006010 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 693970006011 Low molecular weight phosphatase family; Region: LMWPc; cd00115 693970006012 active site 693970006013 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 693970006014 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 693970006015 GTP/Mg2+ binding site [chemical binding]; other site 693970006016 G4 box; other site 693970006017 G5 box; other site 693970006018 G1 box; other site 693970006019 Switch I region; other site 693970006020 G2 box; other site 693970006021 G3 box; other site 693970006022 Switch II region; other site 693970006023 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 693970006024 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 693970006025 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 693970006026 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 693970006027 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 693970006028 methionine sulfoxide reductase A; Provisional; Region: PRK14054 693970006029 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 693970006030 dimer interface [polypeptide binding]; other site 693970006031 active site 693970006032 Schiff base residues; other site 693970006033 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 693970006034 Glycoprotease family; Region: Peptidase_M22; pfam00814 693970006035 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 693970006036 Predicted methyltransferase [General function prediction only]; Region: COG4798 693970006037 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693970006038 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693970006039 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693970006040 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 693970006041 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 693970006042 acyl-activating enzyme (AAE) consensus motif; other site 693970006043 putative AMP binding site [chemical binding]; other site 693970006044 putative active site [active] 693970006045 putative CoA binding site [chemical binding]; other site 693970006046 ribonuclease D; Region: rnd; TIGR01388 693970006047 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 693970006048 catalytic site [active] 693970006049 putative active site [active] 693970006050 putative substrate binding site [chemical binding]; other site 693970006051 HRDC domain; Region: HRDC; pfam00570 693970006052 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 693970006053 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 693970006054 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 693970006055 Switch I; other site 693970006056 Switch II; other site 693970006057 septum formation inhibitor; Reviewed; Region: minC; PRK04804 693970006058 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 693970006059 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 693970006060 YcgL domain; Region: YcgL; pfam05166 693970006061 Transglycosylase SLT domain; Region: SLT_2; pfam13406 693970006062 murein hydrolase B; Provisional; Region: PRK10760; cl17906 693970006063 hypothetical protein; Provisional; Region: PRK05170 693970006064 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693970006065 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970006066 dimer interface [polypeptide binding]; other site 693970006067 putative CheW interface [polypeptide binding]; other site 693970006068 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 693970006069 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 693970006070 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 693970006071 dimer interface [polypeptide binding]; other site 693970006072 motif 1; other site 693970006073 active site 693970006074 motif 2; other site 693970006075 motif 3; other site 693970006076 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 693970006077 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 693970006078 putative tRNA-binding site [nucleotide binding]; other site 693970006079 B3/4 domain; Region: B3_4; pfam03483 693970006080 tRNA synthetase B5 domain; Region: B5; smart00874 693970006081 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 693970006082 dimer interface [polypeptide binding]; other site 693970006083 motif 1; other site 693970006084 motif 3; other site 693970006085 motif 2; other site 693970006086 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 693970006087 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693970006088 IHF dimer interface [polypeptide binding]; other site 693970006089 IHF - DNA interface [nucleotide binding]; other site 693970006090 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 693970006091 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 693970006092 putative acyl-acceptor binding pocket; other site 693970006093 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 693970006094 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693970006095 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 693970006096 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 693970006097 dimerization interface [polypeptide binding]; other site 693970006098 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 693970006099 ATP binding site [chemical binding]; other site 693970006100 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 693970006101 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 693970006102 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 693970006103 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693970006104 Acylphosphatase; Region: Acylphosphatase; pfam00708 693970006105 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 693970006106 HypF finger; Region: zf-HYPF; pfam07503 693970006107 HypF finger; Region: zf-HYPF; pfam07503 693970006108 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 693970006109 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 693970006110 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 693970006111 putative substrate-binding site; other site 693970006112 nickel binding site [ion binding]; other site 693970006113 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 693970006114 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 693970006115 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 693970006116 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 693970006117 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 693970006118 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 693970006119 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693970006120 catalytic residues [active] 693970006121 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 693970006122 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 693970006123 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 693970006124 ApbE family; Region: ApbE; pfam02424 693970006125 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693970006126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970006127 active site 693970006128 phosphorylation site [posttranslational modification] 693970006129 intermolecular recognition site; other site 693970006130 dimerization interface [polypeptide binding]; other site 693970006131 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693970006132 DNA binding site [nucleotide binding] 693970006133 sensor protein QseC; Provisional; Region: PRK10337 693970006134 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970006135 dimer interface [polypeptide binding]; other site 693970006136 phosphorylation site [posttranslational modification] 693970006137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970006138 ATP binding site [chemical binding]; other site 693970006139 Mg2+ binding site [ion binding]; other site 693970006140 G-X-G motif; other site 693970006141 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 693970006142 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 693970006143 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 693970006144 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 693970006145 Ligand binding site; other site 693970006146 DXD motif; other site 693970006147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 693970006148 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693970006149 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693970006150 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693970006151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 693970006152 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 693970006153 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 693970006154 5S rRNA interface [nucleotide binding]; other site 693970006155 CTC domain interface [polypeptide binding]; other site 693970006156 L16 interface [polypeptide binding]; other site 693970006157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 693970006158 Family of unknown function (DUF490); Region: DUF490; pfam04357 693970006159 Family of unknown function (DUF490); Region: DUF490; pfam04357 693970006160 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 693970006161 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693970006162 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693970006163 Surface antigen; Region: Bac_surface_Ag; pfam01103 693970006164 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 693970006165 catalytic nucleophile [active] 693970006166 Predicted membrane protein [Function unknown]; Region: COG4325 693970006167 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 693970006168 FOG: CBS domain [General function prediction only]; Region: COG0517 693970006169 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 693970006170 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 693970006171 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693970006172 ATP binding site [chemical binding]; other site 693970006173 putative Mg++ binding site [ion binding]; other site 693970006174 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970006175 nucleotide binding region [chemical binding]; other site 693970006176 ATP-binding site [chemical binding]; other site 693970006177 Helicase associated domain (HA2); Region: HA2; pfam04408 693970006178 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 693970006179 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 693970006180 Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848 693970006181 NapD protein; Region: NapD; pfam03927 693970006182 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 693970006183 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 693970006184 [4Fe-4S] binding site [ion binding]; other site 693970006185 molybdopterin cofactor binding site; other site 693970006186 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 693970006187 molybdopterin cofactor binding site; other site 693970006188 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 693970006189 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 693970006190 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 693970006191 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 693970006192 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 693970006193 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 693970006194 putative dimer interface [polypeptide binding]; other site 693970006195 putative anticodon binding site; other site 693970006196 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 693970006197 homodimer interface [polypeptide binding]; other site 693970006198 motif 1; other site 693970006199 motif 2; other site 693970006200 active site 693970006201 motif 3; other site 693970006202 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 693970006203 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 693970006204 putative active site [active] 693970006205 putative CoA binding site [chemical binding]; other site 693970006206 nudix motif; other site 693970006207 metal binding site [ion binding]; metal-binding site 693970006208 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 693970006209 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 693970006210 chorismate binding enzyme; Region: Chorismate_bind; cl10555 693970006211 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 693970006212 Fumarase C-terminus; Region: Fumerase_C; pfam05683 693970006213 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 693970006214 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693970006215 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693970006216 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970006217 Coenzyme A binding pocket [chemical binding]; other site 693970006218 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 693970006219 putative active site [active] 693970006220 Zn binding site [ion binding]; other site 693970006221 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 693970006222 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 693970006223 putative catalytic cysteine [active] 693970006224 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 693970006225 putative active site [active] 693970006226 metal binding site [ion binding]; metal-binding site 693970006227 hypothetical protein; Provisional; Region: PRK11111 693970006228 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693970006229 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 693970006230 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693970006231 active site 693970006232 DNA binding site [nucleotide binding] 693970006233 Int/Topo IB signature motif; other site 693970006234 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 693970006235 Transposase; Region: HTH_Tnp_1; pfam01527 693970006236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970006237 putative transposase OrfB; Reviewed; Region: PHA02517 693970006238 HTH-like domain; Region: HTH_21; pfam13276 693970006239 Integrase core domain; Region: rve; pfam00665 693970006240 Integrase core domain; Region: rve_2; pfam13333 693970006241 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693970006242 Transposase; Region: HTH_Tnp_1; cl17663 693970006243 Winged helix-turn helix; Region: HTH_29; pfam13551 693970006244 Homeodomain-like domain; Region: HTH_32; pfam13565 693970006245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970006246 Integrase core domain; Region: rve; pfam00665 693970006247 Integrase core domain; Region: rve_3; pfam13683 693970006248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970006249 Transposase; Region: HTH_Tnp_1; pfam01527 693970006250 putative transposase OrfB; Reviewed; Region: PHA02517 693970006251 HTH-like domain; Region: HTH_21; pfam13276 693970006252 Integrase core domain; Region: rve; pfam00665 693970006253 Integrase core domain; Region: rve_3; pfam13683 693970006254 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693970006255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693970006256 DNA-binding site [nucleotide binding]; DNA binding site 693970006257 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693970006258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970006259 homodimer interface [polypeptide binding]; other site 693970006260 catalytic residue [active] 693970006261 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 693970006262 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 693970006263 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693970006264 EamA-like transporter family; Region: EamA; pfam00892 693970006265 EamA-like transporter family; Region: EamA; pfam00892 693970006266 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693970006267 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 693970006268 two component system sensor kinase SsrB; Provisional; Region: PRK15369 693970006269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970006270 active site 693970006271 phosphorylation site [posttranslational modification] 693970006272 intermolecular recognition site; other site 693970006273 dimerization interface [polypeptide binding]; other site 693970006274 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693970006275 DNA binding residues [nucleotide binding] 693970006276 dimerization interface [polypeptide binding]; other site 693970006277 two component system sensor kinase SsrA; Provisional; Region: PRK15347 693970006278 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970006279 dimerization interface [polypeptide binding]; other site 693970006280 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970006281 dimer interface [polypeptide binding]; other site 693970006282 phosphorylation site [posttranslational modification] 693970006283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970006284 ATP binding site [chemical binding]; other site 693970006285 Mg2+ binding site [ion binding]; other site 693970006286 G-X-G motif; other site 693970006287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970006288 active site 693970006289 phosphorylation site [posttranslational modification] 693970006290 intermolecular recognition site; other site 693970006291 dimerization interface [polypeptide binding]; other site 693970006292 pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368 693970006293 outer membrane secretin SsaC; Provisional; Region: PRK15346 693970006294 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 693970006295 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 693970006296 type III secretion system protein SsaD; Provisional; Region: PRK15367 693970006297 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 693970006298 EspA-like secreted protein; Region: EspA; pfam03433 693970006299 EspA-like secreted protein; Region: EspA; pfam03433 693970006300 pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363 693970006301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970006302 binding surface 693970006303 TPR motif; other site 693970006304 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 693970006305 pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361 693970006306 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 693970006307 Salmonella outer protein D; Region: SopD; cl14701 693970006308 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 693970006309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970006310 binding surface 693970006311 TPR motif; other site 693970006312 pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358 693970006313 Helix-turn-helix domain; Region: HTH_18; pfam12833 693970006314 Type III secretion needle MxiH like; Region: MxiH; cl09641 693970006315 Protein of unknown function (DUF1039); Region: DUF1039; pfam06287 693970006316 Type III secretion needle MxiH like; Region: MxiH; cl09641 693970006317 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 693970006318 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 693970006319 type III secretion system protein SsaK; Provisional; Region: PRK15354 693970006320 HrpJ-like domain; Region: HrpJ; cl15454 693970006321 TyeA; Region: TyeA; cl07611 693970006322 chaperone protein SicP; Provisional; Region: PRK15329 693970006323 SicP binding; Region: SicP-binding; pfam09119 693970006324 type III secretion system protein SsaM; Provisional; Region: PRK15353 693970006325 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 693970006326 FHIPEP family; Region: FHIPEP; pfam00771 693970006327 type III secretion system ATPase; Validated; Region: PRK06820 693970006328 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 693970006329 Walker A motif/ATP binding site; other site 693970006330 Walker B motif; other site 693970006331 type III secretion system protein SsaQ; Validated; Region: PRK08035 693970006332 type III secretion system protein YscR; Provisional; Region: PRK12797 693970006333 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 693970006334 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 693970006335 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 693970006336 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 693970006337 Cupin domain; Region: Cupin_2; cl17218 693970006338 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 693970006339 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 693970006340 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693970006341 EamA-like transporter family; Region: EamA; pfam00892 693970006342 isoaspartyl dipeptidase; Provisional; Region: PRK10657 693970006343 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693970006344 active site 693970006345 hypothetical protein; Provisional; Region: PRK11588 693970006346 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 693970006347 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693970006348 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 693970006349 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693970006350 ligand-binding site [chemical binding]; other site 693970006351 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 693970006352 proposed catalytic triad [active] 693970006353 active site nucleophile [active] 693970006354 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 693970006355 substrate binding site [chemical binding]; other site 693970006356 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 693970006357 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693970006358 ATP binding site [chemical binding]; other site 693970006359 Mg++ binding site [ion binding]; other site 693970006360 motif III; other site 693970006361 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970006362 nucleotide binding region [chemical binding]; other site 693970006363 ATP-binding site [chemical binding]; other site 693970006364 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 693970006365 ribonuclease activity regulator protein RraA; Reviewed; Region: PRK12487 693970006366 AsmA family; Region: AsmA; pfam05170 693970006367 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 693970006368 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 693970006369 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 693970006370 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693970006371 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693970006372 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693970006373 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693970006374 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 693970006375 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693970006376 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 693970006377 Methyltransferase domain; Region: Methyltransf_11; pfam08241 693970006378 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 693970006379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970006380 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 693970006381 putative dimerization interface [polypeptide binding]; other site 693970006382 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 693970006383 RNA/DNA hybrid binding site [nucleotide binding]; other site 693970006384 active site 693970006385 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 693970006386 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 693970006387 active site 693970006388 catalytic site [active] 693970006389 substrate binding site [chemical binding]; other site 693970006390 TIGR03503 family protein; Region: TIGR03503 693970006391 DDE superfamily endonuclease; Region: DDE_3; pfam13358 693970006392 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 693970006393 Transposase; Region: HTH_Tnp_1; pfam01527 693970006394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970006395 putative transposase OrfB; Reviewed; Region: PHA02517 693970006396 HTH-like domain; Region: HTH_21; pfam13276 693970006397 Integrase core domain; Region: rve; pfam00665 693970006398 Integrase core domain; Region: rve_2; pfam13333 693970006399 Transposase; Region: HTH_Tnp_1; pfam01527 693970006400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970006401 putative transposase OrfB; Reviewed; Region: PHA02517 693970006402 HTH-like domain; Region: HTH_21; pfam13276 693970006403 Integrase core domain; Region: rve; pfam00665 693970006404 Integrase core domain; Region: rve_2; pfam13333 693970006405 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693970006406 GAF domain; Region: GAF; pfam01590 693970006407 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970006408 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970006409 metal binding site [ion binding]; metal-binding site 693970006410 active site 693970006411 I-site; other site 693970006412 Response regulator receiver domain; Region: Response_reg; pfam00072 693970006413 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 693970006414 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693970006415 Zn2+ binding site [ion binding]; other site 693970006416 Mg2+ binding site [ion binding]; other site 693970006417 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693970006418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970006419 ATP binding site [chemical binding]; other site 693970006420 Mg2+ binding site [ion binding]; other site 693970006421 G-X-G motif; other site 693970006422 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970006423 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 693970006424 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 693970006425 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970006426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970006427 Walker A motif; other site 693970006428 ATP binding site [chemical binding]; other site 693970006429 Walker B motif; other site 693970006430 Integrase core domain; Region: rve; pfam00665 693970006431 Winged helix-turn helix; Region: HTH_29; pfam13551 693970006432 Homeodomain-like domain; Region: HTH_32; pfam13565 693970006433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970006434 Integrase core domain; Region: rve; pfam00665 693970006435 Transposase; Region: HTH_Tnp_1; cl17663 693970006436 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693970006437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970006438 active site 693970006439 phosphorylation site [posttranslational modification] 693970006440 intermolecular recognition site; other site 693970006441 dimerization interface [polypeptide binding]; other site 693970006442 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693970006443 DNA binding site [nucleotide binding] 693970006444 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 693970006445 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 693970006446 putative active site [active] 693970006447 Zn binding site [ion binding]; other site 693970006448 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 693970006449 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 693970006450 active site 693970006451 homodimer interface [polypeptide binding]; other site 693970006452 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 693970006453 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 693970006454 tandem repeat interface [polypeptide binding]; other site 693970006455 oligomer interface [polypeptide binding]; other site 693970006456 active site residues [active] 693970006457 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 693970006458 tandem repeat interface [polypeptide binding]; other site 693970006459 oligomer interface [polypeptide binding]; other site 693970006460 active site residues [active] 693970006461 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693970006462 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 693970006463 active site 693970006464 FMN binding site [chemical binding]; other site 693970006465 2,4-decadienoyl-CoA binding site; other site 693970006466 catalytic residue [active] 693970006467 4Fe-4S cluster binding site [ion binding]; other site 693970006468 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 693970006469 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693970006470 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 693970006471 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693970006472 catalytic loop [active] 693970006473 iron binding site [ion binding]; other site 693970006474 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 693970006475 dimer interface [polypeptide binding]; other site 693970006476 putative radical transfer pathway; other site 693970006477 diiron center [ion binding]; other site 693970006478 tyrosyl radical; other site 693970006479 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 693970006480 ATP cone domain; Region: ATP-cone; pfam03477 693970006481 Class I ribonucleotide reductase; Region: RNR_I; cd01679 693970006482 active site 693970006483 dimer interface [polypeptide binding]; other site 693970006484 catalytic residues [active] 693970006485 effector binding site; other site 693970006486 R2 peptide binding site; other site 693970006487 phosphoglycolate phosphatase; Provisional; Region: PRK13222 693970006488 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693970006489 motif II; other site 693970006490 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 693970006491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970006492 S-adenosylmethionine binding site [chemical binding]; other site 693970006493 DNA gyrase subunit A; Validated; Region: PRK05560 693970006494 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 693970006495 CAP-like domain; other site 693970006496 active site 693970006497 primary dimer interface [polypeptide binding]; other site 693970006498 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693970006499 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693970006500 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693970006501 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693970006502 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693970006503 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693970006504 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 693970006505 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693970006506 catalytic residue [active] 693970006507 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970006508 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970006509 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 693970006510 substrate binding pocket [chemical binding]; other site 693970006511 dimerization interface [polypeptide binding]; other site 693970006512 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 693970006513 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 693970006514 hypothetical protein; Provisional; Region: PRK10977 693970006515 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 693970006516 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693970006517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970006518 homodimer interface [polypeptide binding]; other site 693970006519 catalytic residue [active] 693970006520 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 693970006521 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 693970006522 hinge; other site 693970006523 active site 693970006524 cytidylate kinase; Provisional; Region: cmk; PRK00023 693970006525 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 693970006526 CMP-binding site; other site 693970006527 The sites determining sugar specificity; other site 693970006528 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 693970006529 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 693970006530 RNA binding site [nucleotide binding]; other site 693970006531 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 693970006532 RNA binding site [nucleotide binding]; other site 693970006533 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 693970006534 RNA binding site [nucleotide binding]; other site 693970006535 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 693970006536 RNA binding site [nucleotide binding]; other site 693970006537 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 693970006538 RNA binding site [nucleotide binding]; other site 693970006539 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 693970006540 RNA binding site [nucleotide binding]; other site 693970006541 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693970006542 IHF dimer interface [polypeptide binding]; other site 693970006543 IHF - DNA interface [nucleotide binding]; other site 693970006544 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 693970006545 tetratricopeptide repeat protein; Provisional; Region: PRK11788 693970006546 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 693970006547 active site 693970006548 dimer interface [polypeptide binding]; other site 693970006549 short chain dehydrogenase; Provisional; Region: PRK07576 693970006550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693970006551 NAD(P) binding site [chemical binding]; other site 693970006552 active site 693970006553 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 693970006554 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 693970006555 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 693970006556 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693970006557 active site 693970006558 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 693970006559 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 693970006560 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 693970006561 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 693970006562 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 693970006563 domain interface [polypeptide binding]; other site 693970006564 putative active site [active] 693970006565 catalytic site [active] 693970006566 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 693970006567 domain interface [polypeptide binding]; other site 693970006568 putative active site [active] 693970006569 catalytic site [active] 693970006570 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 693970006571 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 693970006572 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693970006573 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 693970006574 catalytic residues [active] 693970006575 catalytic nucleophile [active] 693970006576 Presynaptic Site I dimer interface [polypeptide binding]; other site 693970006577 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 693970006578 Synaptic Flat tetramer interface [polypeptide binding]; other site 693970006579 Synaptic Site I dimer interface [polypeptide binding]; other site 693970006580 DNA binding site [nucleotide binding] 693970006581 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 693970006582 DNA-binding interface [nucleotide binding]; DNA binding site 693970006583 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 693970006584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970006585 putative substrate translocation pore; other site 693970006586 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 693970006587 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 693970006588 Uncharacterized conserved protein [Function unknown]; Region: COG3148 693970006589 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 693970006590 Transposase; Region: HTH_Tnp_1; cl17663 693970006591 Winged helix-turn helix; Region: HTH_29; pfam13551 693970006592 Homeodomain-like domain; Region: HTH_32; pfam13565 693970006593 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970006594 Integrase core domain; Region: rve; pfam00665 693970006595 Integrase core domain; Region: rve_3; pfam13683 693970006596 Integrase core domain; Region: rve; pfam00665 693970006597 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970006598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970006599 Walker A motif; other site 693970006600 ATP binding site [chemical binding]; other site 693970006601 Walker B motif; other site 693970006602 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 693970006603 DEAD-like helicases superfamily; Region: DEXDc; smart00487 693970006604 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693970006605 ATP binding site [chemical binding]; other site 693970006606 putative Mg++ binding site [ion binding]; other site 693970006607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970006608 nucleotide binding region [chemical binding]; other site 693970006609 ATP-binding site [chemical binding]; other site 693970006610 ecotin; Provisional; Region: PRK03719 693970006611 secondary substrate binding site; other site 693970006612 primary substrate binding site; other site 693970006613 inhibition loop; other site 693970006614 dimerization interface [polypeptide binding]; other site 693970006615 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693970006616 MarR family; Region: MarR; pfam01047 693970006617 putative metal dependent hydrolase; Provisional; Region: PRK11598 693970006618 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 693970006619 Sulfatase; Region: Sulfatase; pfam00884 693970006620 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970006621 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970006622 metal binding site [ion binding]; metal-binding site 693970006623 active site 693970006624 I-site; other site 693970006625 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 693970006626 CoA binding domain; Region: CoA_binding_2; pfam13380 693970006627 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 693970006628 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 693970006629 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693970006630 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970006631 dimer interface [polypeptide binding]; other site 693970006632 putative CheW interface [polypeptide binding]; other site 693970006633 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 693970006634 anti sigma factor interaction site; other site 693970006635 regulatory phosphorylation site [posttranslational modification]; other site 693970006636 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970006637 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970006638 Integrase core domain; Region: rve; pfam00665 693970006639 Response regulator receiver domain; Region: Response_reg; pfam00072 693970006640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970006641 active site 693970006642 phosphorylation site [posttranslational modification] 693970006643 intermolecular recognition site; other site 693970006644 dimerization interface [polypeptide binding]; other site 693970006645 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693970006646 putative binding surface; other site 693970006647 active site 693970006648 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 693970006649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970006650 ATP binding site [chemical binding]; other site 693970006651 Mg2+ binding site [ion binding]; other site 693970006652 G-X-G motif; other site 693970006653 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 693970006654 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 693970006655 putative CheA interaction surface; other site 693970006656 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693970006657 PAS domain; Region: PAS; smart00091 693970006658 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970006659 dimer interface [polypeptide binding]; other site 693970006660 putative CheW interface [polypeptide binding]; other site 693970006661 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 693970006662 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 693970006663 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 693970006664 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487 693970006665 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 693970006666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970006667 active site 693970006668 phosphorylation site [posttranslational modification] 693970006669 intermolecular recognition site; other site 693970006670 dimerization interface [polypeptide binding]; other site 693970006671 CheB methylesterase; Region: CheB_methylest; pfam01339 693970006672 Hpt domain; Region: Hpt; pfam01627 693970006673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970006674 active site 693970006675 phosphorylation site [posttranslational modification] 693970006676 intermolecular recognition site; other site 693970006677 dimerization interface [polypeptide binding]; other site 693970006678 Response regulator receiver domain; Region: Response_reg; pfam00072 693970006679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970006680 active site 693970006681 phosphorylation site [posttranslational modification] 693970006682 intermolecular recognition site; other site 693970006683 dimerization interface [polypeptide binding]; other site 693970006684 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970006685 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970006686 metal binding site [ion binding]; metal-binding site 693970006687 active site 693970006688 I-site; other site 693970006689 Methyltransferase domain; Region: Methyltransf_25; pfam13649 693970006690 S-adenosylmethionine binding site [chemical binding]; other site 693970006691 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 693970006692 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 693970006693 active site 693970006694 Nuclease-related domain; Region: NERD; pfam08378 693970006695 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 693970006696 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693970006697 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693970006698 ABC transporter; Region: ABC_tran_2; pfam12848 693970006699 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693970006700 Uncharacterized conserved protein [Function unknown]; Region: COG4628 693970006701 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693970006702 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693970006703 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693970006704 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970006705 non-specific DNA binding site [nucleotide binding]; other site 693970006706 salt bridge; other site 693970006707 sequence-specific DNA binding site [nucleotide binding]; other site 693970006708 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693970006709 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970006710 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693970006711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970006712 dimer interface [polypeptide binding]; other site 693970006713 phosphorylation site [posttranslational modification] 693970006714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970006715 ATP binding site [chemical binding]; other site 693970006716 Mg2+ binding site [ion binding]; other site 693970006717 G-X-G motif; other site 693970006718 Response regulator receiver domain; Region: Response_reg; pfam00072 693970006719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970006720 active site 693970006721 phosphorylation site [posttranslational modification] 693970006722 intermolecular recognition site; other site 693970006723 dimerization interface [polypeptide binding]; other site 693970006724 PAS fold; Region: PAS_7; pfam12860 693970006725 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970006726 putative active site [active] 693970006727 heme pocket [chemical binding]; other site 693970006728 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970006729 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970006730 metal binding site [ion binding]; metal-binding site 693970006731 active site 693970006732 I-site; other site 693970006733 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 693970006734 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 693970006735 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 693970006736 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 693970006737 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693970006738 N-terminal plug; other site 693970006739 ligand-binding site [chemical binding]; other site 693970006740 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970006741 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970006742 Integrase core domain; Region: rve; pfam00665 693970006743 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 693970006744 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970006745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970006746 Walker A motif; other site 693970006747 ATP binding site [chemical binding]; other site 693970006748 Walker B motif; other site 693970006749 Integrase core domain; Region: rve; pfam00665 693970006750 Phosphomethylpyrimidine kinase; Region: Phos_pyr_kin; pfam08543 693970006751 ATP binding site [chemical binding]; other site 693970006752 substrate binding site [chemical binding]; other site 693970006753 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 693970006754 thiamine phosphate binding site [chemical binding]; other site 693970006755 active site 693970006756 pyrophosphate binding site [ion binding]; other site 693970006757 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 693970006758 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 693970006759 ATP binding site [chemical binding]; other site 693970006760 substrate interface [chemical binding]; other site 693970006761 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 693970006762 thiS-thiF/thiG interaction site; other site 693970006763 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 693970006764 ThiS interaction site; other site 693970006765 putative active site [active] 693970006766 tetramer interface [polypeptide binding]; other site 693970006767 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 693970006768 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693970006769 FeS/SAM binding site; other site 693970006770 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 693970006771 SprA-related family; Region: SprA-related; pfam12118 693970006772 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970006773 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970006774 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693970006775 dimerization interface [polypeptide binding]; other site 693970006776 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 693970006777 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 693970006778 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 693970006779 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 693970006780 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 693970006781 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693970006782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970006783 S-adenosylmethionine binding site [chemical binding]; other site 693970006784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970006785 S-adenosylmethionine binding site [chemical binding]; other site 693970006786 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693970006787 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693970006788 substrate binding pocket [chemical binding]; other site 693970006789 membrane-bound complex binding site; other site 693970006790 hinge residues; other site 693970006791 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 693970006792 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693970006793 substrate binding pocket [chemical binding]; other site 693970006794 membrane-bound complex binding site; other site 693970006795 hinge residues; other site 693970006796 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693970006797 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693970006798 substrate binding pocket [chemical binding]; other site 693970006799 membrane-bound complex binding site; other site 693970006800 hinge residues; other site 693970006801 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970006802 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970006803 metal binding site [ion binding]; metal-binding site 693970006804 active site 693970006805 I-site; other site 693970006806 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 693970006807 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 693970006808 dimer interface [polypeptide binding]; other site 693970006809 anticodon binding site; other site 693970006810 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 693970006811 homodimer interface [polypeptide binding]; other site 693970006812 motif 1; other site 693970006813 active site 693970006814 motif 2; other site 693970006815 GAD domain; Region: GAD; pfam02938 693970006816 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 693970006817 active site 693970006818 motif 3; other site 693970006819 hypothetical protein; Validated; Region: PRK00110 693970006820 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 693970006821 active site 693970006822 putative DNA-binding cleft [nucleotide binding]; other site 693970006823 dimer interface [polypeptide binding]; other site 693970006824 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 693970006825 RuvA N terminal domain; Region: RuvA_N; pfam01330 693970006826 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 693970006827 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 693970006828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970006829 Walker A motif; other site 693970006830 ATP binding site [chemical binding]; other site 693970006831 Walker B motif; other site 693970006832 arginine finger; other site 693970006833 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 693970006834 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970006835 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970006836 Integrase core domain; Region: rve; pfam00665 693970006837 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970006838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970006839 Walker A motif; other site 693970006840 ATP binding site [chemical binding]; other site 693970006841 Walker B motif; other site 693970006842 Integrase core domain; Region: rve; pfam00665 693970006843 multidrug efflux protein; Reviewed; Region: PRK01766 693970006844 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 693970006845 cation binding site [ion binding]; other site 693970006846 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 693970006847 Lumazine binding domain; Region: Lum_binding; pfam00677 693970006848 Lumazine binding domain; Region: Lum_binding; pfam00677 693970006849 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 693970006850 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 693970006851 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 693970006852 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 693970006853 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 693970006854 active site 693970006855 dimer interface [polypeptide binding]; other site 693970006856 motif 1; other site 693970006857 motif 2; other site 693970006858 motif 3; other site 693970006859 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 693970006860 anticodon binding site; other site 693970006861 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 693970006862 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 693970006863 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 693970006864 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 693970006865 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 693970006866 23S rRNA binding site [nucleotide binding]; other site 693970006867 L21 binding site [polypeptide binding]; other site 693970006868 L13 binding site [polypeptide binding]; other site 693970006869 thioredoxin reductase; Provisional; Region: PRK10262 693970006870 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693970006871 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693970006872 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970006873 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970006874 Integrase core domain; Region: rve; pfam00665 693970006875 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 693970006876 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 693970006877 hexamer interface [polypeptide binding]; other site 693970006878 ligand binding site [chemical binding]; other site 693970006879 putative active site [active] 693970006880 NAD(P) binding site [chemical binding]; other site 693970006881 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 693970006882 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693970006883 putative DNA binding site [nucleotide binding]; other site 693970006884 putative Zn2+ binding site [ion binding]; other site 693970006885 AsnC family; Region: AsnC_trans_reg; pfam01037 693970006886 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 693970006887 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 693970006888 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 693970006889 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 693970006890 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 693970006891 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 693970006892 recombination factor protein RarA; Reviewed; Region: PRK13342 693970006893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970006894 Walker A motif; other site 693970006895 ATP binding site [chemical binding]; other site 693970006896 Walker B motif; other site 693970006897 arginine finger; other site 693970006898 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 693970006899 camphor resistance protein CrcB; Provisional; Region: PRK14197 693970006900 seryl-tRNA synthetase; Provisional; Region: PRK05431 693970006901 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 693970006902 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 693970006903 dimer interface [polypeptide binding]; other site 693970006904 active site 693970006905 motif 1; other site 693970006906 motif 2; other site 693970006907 motif 3; other site 693970006908 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 693970006909 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 693970006910 sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011 693970006911 sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010 693970006912 sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012 693970006913 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 693970006914 YccA-like proteins; Region: YccA_like; cd10433 693970006915 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 693970006916 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970006917 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693970006918 dimerization interface [polypeptide binding]; other site 693970006919 putative transporter; Provisional; Region: PRK11043 693970006920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970006921 putative substrate translocation pore; other site 693970006922 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 693970006923 putative efflux protein, MATE family; Region: matE; TIGR00797 693970006924 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693970006925 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693970006926 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 693970006927 catalytic residues [active] 693970006928 catalytic nucleophile [active] 693970006929 Presynaptic Site I dimer interface [polypeptide binding]; other site 693970006930 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 693970006931 Synaptic Flat tetramer interface [polypeptide binding]; other site 693970006932 Synaptic Site I dimer interface [polypeptide binding]; other site 693970006933 DNA binding site [nucleotide binding] 693970006934 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 693970006935 DNA-binding interface [nucleotide binding]; DNA binding site 693970006936 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 693970006937 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 693970006938 Phage X family; Region: Phage_X; cl11585 693970006939 Helix-destabilising protein; Region: Phage_DNA_bind; pfam02303 693970006940 hypothetical protein; Region: PHA01080 693970006941 putative major coat protein; Region: PHA00979 693970006942 Protein of unknown function (DUF2523); Region: DUF2523; cl10291 693970006943 putative assembly protein; Region: PHA00350 693970006944 Zonular occludens toxin (Zot); Region: Zot; cl17485 693970006945 replication initiation protein; Region: II; PHA00360 693970006946 Phage replication protein CRI; Region: Phage_CRI; pfam05144 693970006947 Phage X family; Region: Phage_X; pfam05155 693970006948 hypothetical protein; Region: PHA01159 693970006949 putative assembly protein; Region: PHA00350 693970006950 Zonular occludens toxin (Zot); Region: Zot; cl17485 693970006951 replication initiation protein; Region: II; PHA00360 693970006952 Phage replication protein CRI; Region: Phage_CRI; pfam05144 693970006953 Phage X family; Region: Phage_X; pfam05155 693970006954 hypothetical protein; Region: PHA01159 693970006955 putative assembly protein; Region: PHA00350 693970006956 Zonular occludens toxin (Zot); Region: Zot; cl17485 693970006957 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 693970006958 Int/Topo IB signature motif; other site 693970006959 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693970006960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 693970006961 active site 693970006962 phosphorylation site [posttranslational modification] 693970006963 intermolecular recognition site; other site 693970006964 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 693970006965 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693970006966 Zn2+ binding site [ion binding]; other site 693970006967 Mg2+ binding site [ion binding]; other site 693970006968 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 693970006969 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 693970006970 Low-spin heme binding site [chemical binding]; other site 693970006971 Putative water exit pathway; other site 693970006972 Binuclear center (active site) [active] 693970006973 Putative proton exit pathway; other site 693970006974 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 693970006975 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 693970006976 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 693970006977 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 693970006978 Cytochrome c; Region: Cytochrom_C; pfam00034 693970006979 Cytochrome c; Region: Cytochrom_C; pfam00034 693970006980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 693970006981 FixH; Region: FixH; pfam05751 693970006982 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 693970006983 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 693970006984 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693970006985 metal-binding site [ion binding] 693970006986 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693970006987 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 693970006988 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 693970006989 Family description; Region: DsbD_2; pfam13386 693970006990 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 693970006991 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693970006992 ligand binding site [chemical binding]; other site 693970006993 flexible hinge region; other site 693970006994 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 693970006995 putative switch regulator; other site 693970006996 non-specific DNA interactions [nucleotide binding]; other site 693970006997 DNA binding site [nucleotide binding] 693970006998 sequence specific DNA binding site [nucleotide binding]; other site 693970006999 putative cAMP binding site [chemical binding]; other site 693970007000 universal stress protein UspE; Provisional; Region: PRK11175 693970007001 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693970007002 Ligand Binding Site [chemical binding]; other site 693970007003 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693970007004 Ligand Binding Site [chemical binding]; other site 693970007005 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 693970007006 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 693970007007 Ligand Binding Site [chemical binding]; other site 693970007008 Protein of unknown function (DUF2987); Region: DUF2987; pfam11205 693970007009 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 693970007010 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 693970007011 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 693970007012 phosphate binding site [ion binding]; other site 693970007013 putative substrate binding pocket [chemical binding]; other site 693970007014 dimer interface [polypeptide binding]; other site 693970007015 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 693970007016 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693970007017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970007018 homodimer interface [polypeptide binding]; other site 693970007019 catalytic residue [active] 693970007020 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 693970007021 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 693970007022 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 693970007023 Protein of unknown function (DUF2989); Region: DUF2989; pfam11207 693970007024 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 693970007025 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 693970007026 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 693970007027 quinolinate synthetase; Provisional; Region: PRK09375 693970007028 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 693970007029 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693970007030 E3 interaction surface; other site 693970007031 lipoyl attachment site [posttranslational modification]; other site 693970007032 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693970007033 E3 interaction surface; other site 693970007034 lipoyl attachment site [posttranslational modification]; other site 693970007035 e3 binding domain; Region: E3_binding; pfam02817 693970007036 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693970007037 3-methyl-2-oxobutanate dehydrogenase; Provisional; Region: PTZ00182 693970007038 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 693970007039 alpha subunit interface [polypeptide binding]; other site 693970007040 TPP binding site [chemical binding]; other site 693970007041 heterodimer interface [polypeptide binding]; other site 693970007042 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693970007043 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 693970007044 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 693970007045 tetramer interface [polypeptide binding]; other site 693970007046 TPP-binding site [chemical binding]; other site 693970007047 heterodimer interface [polypeptide binding]; other site 693970007048 phosphorylation loop region [posttranslational modification] 693970007049 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 693970007050 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 693970007051 putative active site [active] 693970007052 Zn binding site [ion binding]; other site 693970007053 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 693970007054 phosphoglucomutase; Validated; Region: PRK07564 693970007055 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 693970007056 active site 693970007057 substrate binding site [chemical binding]; other site 693970007058 metal binding site [ion binding]; metal-binding site 693970007059 replication initiation regulator SeqA; Provisional; Region: PRK11187 693970007060 PGAP1-like protein; Region: PGAP1; pfam07819 693970007061 acyl-CoA esterase; Provisional; Region: PRK10673 693970007062 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 693970007063 LexA regulated protein; Provisional; Region: PRK11675 693970007064 flavodoxin FldA; Validated; Region: PRK09267 693970007065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 693970007066 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 693970007067 elongation factor P; Validated; Region: PRK00529 693970007068 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 693970007069 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 693970007070 RNA binding site [nucleotide binding]; other site 693970007071 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 693970007072 RNA binding site [nucleotide binding]; other site 693970007073 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 693970007074 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693970007075 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 693970007076 Short chain fatty acid transporter; Region: SCFA_trans; cl17380 693970007077 aminotransferase AlaT; Validated; Region: PRK09265 693970007078 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693970007079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970007080 homodimer interface [polypeptide binding]; other site 693970007081 catalytic residue [active] 693970007082 5'-nucleotidase; Provisional; Region: PRK03826 693970007083 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 693970007084 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 693970007085 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 693970007086 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 693970007087 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 693970007088 active site 693970007089 intersubunit interface [polypeptide binding]; other site 693970007090 catalytic residue [active] 693970007091 phosphogluconate dehydratase; Validated; Region: PRK09054 693970007092 6-phosphogluconate dehydratase; Region: edd; TIGR01196 693970007093 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 693970007094 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 693970007095 putative active site [active] 693970007096 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 693970007097 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 693970007098 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 693970007099 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 693970007100 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693970007101 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693970007102 putative active site [active] 693970007103 pyruvate kinase; Provisional; Region: PRK05826 693970007104 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 693970007105 domain interfaces; other site 693970007106 active site 693970007107 acyl-CoA dehydrogenase; Reviewed; Region: PRK13026 693970007108 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693970007109 active site 693970007110 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 693970007111 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693970007112 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693970007113 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 693970007114 active site 693970007115 Zn binding site [ion binding]; other site 693970007116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 693970007117 Smr domain; Region: Smr; pfam01713 693970007118 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 693970007119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 693970007120 SEC-C motif; Region: SEC-C; pfam02810 693970007121 SEC-C motif; Region: SEC-C; pfam02810 693970007122 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693970007123 GAF domain; Region: GAF; pfam01590 693970007124 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970007125 PAS domain; Region: PAS_9; pfam13426 693970007126 putative active site [active] 693970007127 heme pocket [chemical binding]; other site 693970007128 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970007129 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970007130 metal binding site [ion binding]; metal-binding site 693970007131 active site 693970007132 I-site; other site 693970007133 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970007134 Protein of unknown function (DUF406); Region: DUF406; pfam04175 693970007135 Ribosomal S4P (gammaproteobacterial); Region: Ribosomal_S4Pg; pfam11993 693970007136 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 693970007137 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 693970007138 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693970007139 catalytic residue [active] 693970007140 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 693970007141 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 693970007142 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 693970007143 Ligand Binding Site [chemical binding]; other site 693970007144 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 693970007145 excinuclease ABC subunit B; Provisional; Region: PRK05298 693970007146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693970007147 ATP binding site [chemical binding]; other site 693970007148 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970007149 nucleotide binding region [chemical binding]; other site 693970007150 ATP-binding site [chemical binding]; other site 693970007151 Ultra-violet resistance protein B; Region: UvrB; pfam12344 693970007152 UvrB/uvrC motif; Region: UVR; pfam02151 693970007153 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970007154 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970007155 active site 693970007156 I-site; other site 693970007157 metal binding site [ion binding]; metal-binding site 693970007158 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970007159 electron transport complex protein RsxA; Provisional; Region: PRK05151 693970007160 ferredoxin; Provisional; Region: PRK08764 693970007161 Putative Fe-S cluster; Region: FeS; pfam04060 693970007162 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 693970007163 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 693970007164 SLBB domain; Region: SLBB; pfam10531 693970007165 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693970007166 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 693970007167 electron transport complex protein RnfG; Validated; Region: PRK01908 693970007168 electron transport complex RsxE subunit; Provisional; Region: PRK12405 693970007169 endonuclease III; Provisional; Region: PRK10702 693970007170 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693970007171 minor groove reading motif; other site 693970007172 helix-hairpin-helix signature motif; other site 693970007173 substrate binding pocket [chemical binding]; other site 693970007174 active site 693970007175 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 693970007176 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693970007177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970007178 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 693970007179 dimerization interface [polypeptide binding]; other site 693970007180 substrate binding pocket [chemical binding]; other site 693970007181 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 693970007182 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693970007183 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 693970007184 dimer interface [polypeptide binding]; other site 693970007185 active site 693970007186 metal binding site [ion binding]; metal-binding site 693970007187 glutathione binding site [chemical binding]; other site 693970007188 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 693970007189 TMAO/DMSO reductase; Reviewed; Region: PRK05363 693970007190 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 693970007191 Moco binding site; other site 693970007192 metal coordination site [ion binding]; other site 693970007193 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 693970007194 RmuC family; Region: RmuC; pfam02646 693970007195 lytic murein transglycosylase; Provisional; Region: PRK11619 693970007196 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693970007197 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693970007198 catalytic residue [active] 693970007199 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970007200 MoxR-like ATPases [General function prediction only]; Region: COG0714 693970007201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970007202 Walker A motif; other site 693970007203 ATP binding site [chemical binding]; other site 693970007204 Walker B motif; other site 693970007205 arginine finger; other site 693970007206 Protein of unknown function DUF58; Region: DUF58; pfam01882 693970007207 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 693970007208 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 693970007209 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 693970007210 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 693970007211 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 693970007212 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 693970007213 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 693970007214 Part of AAA domain; Region: AAA_19; pfam13245 693970007215 Family description; Region: UvrD_C_2; pfam13538 693970007216 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 693970007217 AAA domain; Region: AAA_30; pfam13604 693970007218 Family description; Region: UvrD_C_2; pfam13538 693970007219 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693970007220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970007221 Coenzyme A binding pocket [chemical binding]; other site 693970007222 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970007223 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970007224 metal binding site [ion binding]; metal-binding site 693970007225 active site 693970007226 I-site; other site 693970007227 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 693970007228 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 693970007229 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693970007230 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693970007231 GAF domain; Region: GAF; pfam01590 693970007232 PAS domain; Region: PAS_9; pfam13426 693970007233 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970007234 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970007235 metal binding site [ion binding]; metal-binding site 693970007236 active site 693970007237 I-site; other site 693970007238 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970007239 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 693970007240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970007241 S-adenosylmethionine binding site [chemical binding]; other site 693970007242 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 693970007243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970007244 putative substrate translocation pore; other site 693970007245 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 693970007246 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 693970007247 active site 693970007248 catalytic site [active] 693970007249 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 693970007250 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970007251 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970007252 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 693970007253 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 693970007254 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 693970007255 Ca binding site [ion binding]; other site 693970007256 active site 693970007257 homodimer interface [polypeptide binding]; other site 693970007258 catalytic site [active] 693970007259 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 693970007260 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349 693970007261 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 693970007262 active site 693970007263 catalytic site [active] 693970007264 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 693970007265 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693970007266 putative metal binding site [ion binding]; other site 693970007267 pyruvate dehydrogenase; Provisional; Region: PRK06546 693970007268 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 693970007269 PYR/PP interface [polypeptide binding]; other site 693970007270 dimer interface [polypeptide binding]; other site 693970007271 tetramer interface [polypeptide binding]; other site 693970007272 TPP binding site [chemical binding]; other site 693970007273 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693970007274 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 693970007275 TPP-binding site [chemical binding]; other site 693970007276 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693970007277 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 693970007278 PRC-barrel domain; Region: PRC; pfam05239 693970007279 PRC-barrel domain; Region: PRC; pfam05239 693970007280 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 693970007281 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 693970007282 Walker A/P-loop; other site 693970007283 ATP binding site [chemical binding]; other site 693970007284 Q-loop/lid; other site 693970007285 ABC transporter signature motif; other site 693970007286 Walker B; other site 693970007287 D-loop; other site 693970007288 H-loop/switch region; other site 693970007289 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 693970007290 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 693970007291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693970007292 dimer interface [polypeptide binding]; other site 693970007293 conserved gate region; other site 693970007294 ABC-ATPase subunit interface; other site 693970007295 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 693970007296 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 693970007297 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693970007298 rhombotail lipoprotein; Region: rhombo_lipo; TIGR04179 693970007299 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 693970007300 active site 693970007301 catalytic residues [active] 693970007302 metal binding site [ion binding]; metal-binding site 693970007303 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 693970007304 active site 693970007305 DNA binding site [nucleotide binding] 693970007306 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 693970007307 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 693970007308 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 693970007309 putative active site [active] 693970007310 putative dimer interface [polypeptide binding]; other site 693970007311 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 693970007312 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 693970007313 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 693970007314 active site 693970007315 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 693970007316 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 693970007317 TrkA-N domain; Region: TrkA_N; pfam02254 693970007318 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693970007319 active site 693970007320 Int/Topo IB signature motif; other site 693970007321 catalytic residues [active] 693970007322 DNA binding site [nucleotide binding] 693970007323 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693970007324 Zn2+ binding site [ion binding]; other site 693970007325 Mg2+ binding site [ion binding]; other site 693970007326 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 693970007327 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 693970007328 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693970007329 active site 693970007330 DNA binding site [nucleotide binding] 693970007331 Int/Topo IB signature motif; other site 693970007332 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 693970007333 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 693970007334 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 693970007335 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 693970007336 putative active site [active] 693970007337 putative NTP binding site [chemical binding]; other site 693970007338 putative nucleic acid binding site [nucleotide binding]; other site 693970007339 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 693970007340 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 693970007341 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693970007342 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 693970007343 active site 693970007344 nucleotide binding site [chemical binding]; other site 693970007345 HIGH motif; other site 693970007346 KMSKS motif; other site 693970007347 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970007348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970007349 Walker A motif; other site 693970007350 ATP binding site [chemical binding]; other site 693970007351 Walker B motif; other site 693970007352 Integrase core domain; Region: rve; pfam00665 693970007353 Haemolysin-III related; Region: HlyIII; cl03831 693970007354 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 693970007355 DTW domain; Region: DTW; cl01221 693970007356 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_27; cd04686 693970007357 nudix motif; other site 693970007358 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 693970007359 Family of unknown function (DUF633); Region: DUF633; pfam04816 693970007360 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 693970007361 Helix-turn-helix domain; Region: HTH_18; pfam12833 693970007362 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 693970007363 Uncharacterized conserved protein [Function unknown]; Region: COG2128 693970007364 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 693970007365 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 693970007366 putative RNA binding site [nucleotide binding]; other site 693970007367 Transposase; Region: HTH_Tnp_1; cl17663 693970007368 Winged helix-turn helix; Region: HTH_29; pfam13551 693970007369 Homeodomain-like domain; Region: HTH_32; pfam13565 693970007370 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970007371 Integrase core domain; Region: rve; pfam00665 693970007372 Integrase core domain; Region: rve_3; pfam13683 693970007373 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 693970007374 Catalytic domain of Protein Kinases; Region: PKc; cd00180 693970007375 active site 693970007376 ATP binding site [chemical binding]; other site 693970007377 substrate binding site [chemical binding]; other site 693970007378 activation loop (A-loop); other site 693970007379 glycogen synthase; Provisional; Region: glgA; PRK00654 693970007380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970007381 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693970007382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970007383 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693970007384 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693970007385 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693970007386 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693970007387 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693970007388 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 693970007389 Citrate transporter; Region: CitMHS; pfam03600 693970007390 transmembrane helices; other site 693970007391 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 693970007392 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693970007393 Catalytic site [active] 693970007394 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 693970007395 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 693970007396 active site 693970007397 DNA binding site [nucleotide binding] 693970007398 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 693970007399 Uncharacterized conserved protein [Function unknown]; Region: COG2850 693970007400 Cupin-like domain; Region: Cupin_8; pfam13621 693970007401 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 693970007402 active site 693970007403 catalytic site [active] 693970007404 substrate binding site [chemical binding]; other site 693970007405 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693970007406 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693970007407 DNA binding site [nucleotide binding] 693970007408 domain linker motif; other site 693970007409 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 693970007410 putative dimerization interface [polypeptide binding]; other site 693970007411 putative ligand binding site [chemical binding]; other site 693970007412 Protein of unknown function (DUF3334); Region: DUF3334; pfam11813 693970007413 Cache domain; Region: Cache_2; pfam08269 693970007414 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693970007415 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970007416 dimerization interface [polypeptide binding]; other site 693970007417 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970007418 dimer interface [polypeptide binding]; other site 693970007419 putative CheW interface [polypeptide binding]; other site 693970007420 Uncharacterized conserved protein [Function unknown]; Region: COG3603 693970007421 Family description; Region: ACT_7; pfam13840 693970007422 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 693970007423 dimerization domain swap beta strand [polypeptide binding]; other site 693970007424 regulatory protein interface [polypeptide binding]; other site 693970007425 active site 693970007426 regulatory phosphorylation site [posttranslational modification]; other site 693970007427 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 693970007428 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 693970007429 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693970007430 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693970007431 PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439 693970007432 HPr interaction site; other site 693970007433 glycerol kinase (GK) interaction site [polypeptide binding]; other site 693970007434 active site 693970007435 phosphorylation site [posttranslational modification] 693970007436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970007437 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693970007438 putative substrate translocation pore; other site 693970007439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970007440 Vibrio chemotaxis protein N terminus; Region: MCP_N; pfam05581 693970007441 Cache domain; Region: Cache_1; pfam02743 693970007442 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693970007443 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970007444 dimerization interface [polypeptide binding]; other site 693970007445 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970007446 dimer interface [polypeptide binding]; other site 693970007447 putative CheW interface [polypeptide binding]; other site 693970007448 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693970007449 trimer interface [polypeptide binding]; other site 693970007450 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693970007451 eyelet of channel; other site 693970007452 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 693970007453 ArsC family; Region: ArsC; pfam03960 693970007454 putative catalytic residues [active] 693970007455 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 693970007456 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 693970007457 metal binding site [ion binding]; metal-binding site 693970007458 dimer interface [polypeptide binding]; other site 693970007459 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 693970007460 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 693970007461 PBP superfamily domain; Region: PBP_like_2; cl17296 693970007462 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 693970007463 active site clefts [active] 693970007464 zinc binding site [ion binding]; other site 693970007465 dimer interface [polypeptide binding]; other site 693970007466 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 693970007467 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 693970007468 inhibitor-cofactor binding pocket; inhibition site 693970007469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970007470 catalytic residue [active] 693970007471 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 693970007472 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 693970007473 active site 693970007474 NAD binding site [chemical binding]; other site 693970007475 metal binding site [ion binding]; metal-binding site 693970007476 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 693970007477 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 693970007478 Ligand binding site; other site 693970007479 oligomer interface; other site 693970007480 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 693970007481 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 693970007482 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 693970007483 active site residue [active] 693970007484 GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060 693970007485 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693970007486 putative GSH binding site (G-site) [chemical binding]; other site 693970007487 active site cysteine [active] 693970007488 putative C-terminal domain interface [polypeptide binding]; other site 693970007489 putative dimer interface [polypeptide binding]; other site 693970007490 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 693970007491 putative N-terminal domain interface [polypeptide binding]; other site 693970007492 putative dimer interface [polypeptide binding]; other site 693970007493 putative substrate binding pocket (H-site) [chemical binding]; other site 693970007494 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 693970007495 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 693970007496 Sulfate transporter family; Region: Sulfate_transp; pfam00916 693970007497 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 693970007498 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693970007499 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693970007500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693970007501 DNA-binding site [nucleotide binding]; DNA binding site 693970007502 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693970007503 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970007504 homodimer interface [polypeptide binding]; other site 693970007505 catalytic residue [active] 693970007506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970007507 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 693970007508 putative substrate translocation pore; other site 693970007509 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08979 693970007510 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693970007511 PYR/PP interface [polypeptide binding]; other site 693970007512 dimer interface [polypeptide binding]; other site 693970007513 TPP binding site [chemical binding]; other site 693970007514 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693970007515 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 693970007516 TPP-binding site [chemical binding]; other site 693970007517 dimer interface [polypeptide binding]; other site 693970007518 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 693970007519 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 693970007520 putative valine binding site [chemical binding]; other site 693970007521 dimer interface [polypeptide binding]; other site 693970007522 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 693970007523 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 693970007524 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 693970007525 putative dimer interface [polypeptide binding]; other site 693970007526 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 693970007527 active site 693970007528 multimer interface [polypeptide binding]; other site 693970007529 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 693970007530 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 693970007531 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693970007532 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 693970007533 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693970007534 catalytic loop [active] 693970007535 iron binding site [ion binding]; other site 693970007536 chaperone protein HscA; Provisional; Region: hscA; PRK05183 693970007537 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 693970007538 nucleotide binding site [chemical binding]; other site 693970007539 putative NEF/HSP70 interaction site [polypeptide binding]; other site 693970007540 SBD interface [polypeptide binding]; other site 693970007541 co-chaperone HscB; Provisional; Region: hscB; PRK05014 693970007542 DnaJ domain; Region: DnaJ; pfam00226 693970007543 HSP70 interaction site [polypeptide binding]; other site 693970007544 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 693970007545 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 693970007546 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 693970007547 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 693970007548 trimerization site [polypeptide binding]; other site 693970007549 active site 693970007550 cysteine desulfurase; Provisional; Region: PRK14012 693970007551 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 693970007552 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693970007553 catalytic residue [active] 693970007554 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 693970007555 Rrf2 family protein; Region: rrf2_super; TIGR00738 693970007556 serine O-acetyltransferase; Region: cysE; TIGR01172 693970007557 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 693970007558 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 693970007559 trimer interface [polypeptide binding]; other site 693970007560 active site 693970007561 substrate binding site [chemical binding]; other site 693970007562 CoA binding site [chemical binding]; other site 693970007563 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 693970007564 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 693970007565 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 693970007566 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 693970007567 active site 693970007568 dimerization interface [polypeptide binding]; other site 693970007569 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 693970007570 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693970007571 FtsX-like permease family; Region: FtsX; pfam02687 693970007572 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 693970007573 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693970007574 Walker A/P-loop; other site 693970007575 ATP binding site [chemical binding]; other site 693970007576 Q-loop/lid; other site 693970007577 ABC transporter signature motif; other site 693970007578 Walker B; other site 693970007579 D-loop; other site 693970007580 H-loop/switch region; other site 693970007581 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 693970007582 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693970007583 transcription-repair coupling factor; Provisional; Region: PRK10689 693970007584 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 693970007585 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693970007586 ATP binding site [chemical binding]; other site 693970007587 putative Mg++ binding site [ion binding]; other site 693970007588 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970007589 nucleotide binding region [chemical binding]; other site 693970007590 ATP-binding site [chemical binding]; other site 693970007591 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 693970007592 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 693970007593 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 693970007594 acylphosphatase; Provisional; Region: PRK14429 693970007595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693970007596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693970007597 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 693970007598 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 693970007599 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 693970007600 putative active site [active] 693970007601 putative NTP binding site [chemical binding]; other site 693970007602 putative nucleic acid binding site [nucleotide binding]; other site 693970007603 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 693970007604 hypothetical protein; Provisional; Region: PRK04940 693970007605 beta-hexosaminidase; Provisional; Region: PRK05337 693970007606 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 693970007607 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 693970007608 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 693970007609 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 693970007610 S-formylglutathione hydrolase; Region: PLN02442 693970007611 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 693970007612 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 693970007613 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 693970007614 substrate binding site [chemical binding]; other site 693970007615 catalytic Zn binding site [ion binding]; other site 693970007616 NAD binding site [chemical binding]; other site 693970007617 structural Zn binding site [ion binding]; other site 693970007618 dimer interface [polypeptide binding]; other site 693970007619 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970007620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970007621 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 693970007622 putative effector binding pocket; other site 693970007623 putative dimerization interface [polypeptide binding]; other site 693970007624 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 693970007625 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693970007626 Protein of unknown function (DUF938); Region: DUF938; pfam06080 693970007627 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 693970007628 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693970007629 N-terminal plug; other site 693970007630 ligand-binding site [chemical binding]; other site 693970007631 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 693970007632 DEAD/DEAH box helicase; Region: DEAD; pfam00270 693970007633 DEAD_2; Region: DEAD_2; pfam06733 693970007634 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 693970007635 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 693970007636 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 693970007637 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 693970007638 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 693970007639 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 693970007640 NAD binding site [chemical binding]; other site 693970007641 dimerization interface [polypeptide binding]; other site 693970007642 product binding site; other site 693970007643 substrate binding site [chemical binding]; other site 693970007644 zinc binding site [ion binding]; other site 693970007645 catalytic residues [active] 693970007646 histidinol-phosphate aminotransferase; Provisional; Region: PRK04635 693970007647 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693970007648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970007649 homodimer interface [polypeptide binding]; other site 693970007650 catalytic residue [active] 693970007651 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 693970007652 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693970007653 active site 693970007654 motif I; other site 693970007655 motif II; other site 693970007656 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 693970007657 putative active site pocket [active] 693970007658 4-fold oligomerization interface [polypeptide binding]; other site 693970007659 metal binding residues [ion binding]; metal-binding site 693970007660 3-fold/trimer interface [polypeptide binding]; other site 693970007661 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 693970007662 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 693970007663 putative active site [active] 693970007664 oxyanion strand; other site 693970007665 catalytic triad [active] 693970007666 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 693970007667 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 693970007668 catalytic residues [active] 693970007669 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 693970007670 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 693970007671 substrate binding site [chemical binding]; other site 693970007672 glutamase interaction surface [polypeptide binding]; other site 693970007673 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 693970007674 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 693970007675 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 693970007676 metal binding site [ion binding]; metal-binding site 693970007677 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 693970007678 aromatic amino acid transport protein; Region: araaP; TIGR00837 693970007679 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 693970007680 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 693970007681 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 693970007682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970007683 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693970007684 Coenzyme A binding pocket [chemical binding]; other site 693970007685 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 693970007686 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 693970007687 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 693970007688 quinone interaction residues [chemical binding]; other site 693970007689 active site 693970007690 catalytic residues [active] 693970007691 FMN binding site [chemical binding]; other site 693970007692 substrate binding site [chemical binding]; other site 693970007693 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 693970007694 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 693970007695 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 693970007696 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 693970007697 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 693970007698 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 693970007699 aminopeptidase N; Provisional; Region: pepN; PRK14015 693970007700 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 693970007701 active site 693970007702 Zn binding site [ion binding]; other site 693970007703 carboxy-terminal protease; Provisional; Region: PRK11186 693970007704 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 693970007705 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 693970007706 protein binding site [polypeptide binding]; other site 693970007707 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 693970007708 Catalytic dyad [active] 693970007709 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 693970007710 ProP expression regulator; Provisional; Region: PRK04950 693970007711 ProQ/FINO family; Region: ProQ; smart00945 693970007712 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 693970007713 GAF domain; Region: GAF_2; pfam13185 693970007714 YebG protein; Region: YebG; pfam07130 693970007715 Paraquat-inducible protein A; Region: PqiA; pfam04403 693970007716 Paraquat-inducible protein A; Region: PqiA; pfam04403 693970007717 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 693970007718 mce related protein; Region: MCE; pfam02470 693970007719 mce related protein; Region: MCE; pfam02470 693970007720 mce related protein; Region: MCE; pfam02470 693970007721 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 693970007722 mce related protein; Region: MCE; pfam02470 693970007723 mce related protein; Region: MCE; pfam02470 693970007724 mce related protein; Region: MCE; pfam02470 693970007725 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 693970007726 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 693970007727 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 693970007728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970007729 S-adenosylmethionine binding site [chemical binding]; other site 693970007730 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 693970007731 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 693970007732 active site 693970007733 PilZ domain; Region: PilZ; cl01260 693970007734 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 693970007735 DNA polymerase III subunit delta'; Validated; Region: PRK08485 693970007736 thymidylate kinase; Validated; Region: tmk; PRK00698 693970007737 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 693970007738 TMP-binding site; other site 693970007739 ATP-binding site [chemical binding]; other site 693970007740 YceG-like family; Region: YceG; pfam02618 693970007741 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 693970007742 dimerization interface [polypeptide binding]; other site 693970007743 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 693970007744 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 693970007745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970007746 catalytic residue [active] 693970007747 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 693970007748 trimer interface [polypeptide binding]; other site 693970007749 active site 693970007750 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 693970007751 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 693970007752 Sugar specificity; other site 693970007753 Pyrimidine base specificity; other site 693970007754 ATP-binding site [chemical binding]; other site 693970007755 antiporter inner membrane protein; Provisional; Region: PRK11670 693970007756 Domain of unknown function DUF59; Region: DUF59; cl00941 693970007757 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 693970007758 Walker A motif; other site 693970007759 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693970007760 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 693970007761 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 693970007762 active site 693970007763 HIGH motif; other site 693970007764 KMSKS motif; other site 693970007765 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 693970007766 tRNA binding surface [nucleotide binding]; other site 693970007767 anticodon binding site; other site 693970007768 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 693970007769 dimer interface [polypeptide binding]; other site 693970007770 putative tRNA-binding site [nucleotide binding]; other site 693970007771 Predicted permeases [General function prediction only]; Region: COG0679 693970007772 Uncharacterized conserved protein [Function unknown]; Region: COG0327 693970007773 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 693970007774 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 693970007775 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 693970007776 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 693970007777 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 693970007778 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 693970007779 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 693970007780 rRNA binding site [nucleotide binding]; other site 693970007781 predicted 30S ribosome binding site; other site 693970007782 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 693970007783 Clp amino terminal domain; Region: Clp_N; pfam02861 693970007784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970007785 Walker A motif; other site 693970007786 ATP binding site [chemical binding]; other site 693970007787 Walker B motif; other site 693970007788 arginine finger; other site 693970007789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970007790 Walker A motif; other site 693970007791 ATP binding site [chemical binding]; other site 693970007792 Walker B motif; other site 693970007793 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 693970007794 Uncharacterized conserved protein [Function unknown]; Region: COG2127 693970007795 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693970007796 DNA-binding site [nucleotide binding]; DNA binding site 693970007797 RNA-binding motif; other site 693970007798 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 693970007799 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 693970007800 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 693970007801 pseudouridine synthase; Region: TIGR00093 693970007802 probable active site [active] 693970007803 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 693970007804 nudix motif; other site 693970007805 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 693970007806 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 693970007807 putative lysogenization regulator; Reviewed; Region: PRK00218 693970007808 adenylosuccinate lyase; Provisional; Region: PRK09285 693970007809 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 693970007810 tetramer interface [polypeptide binding]; other site 693970007811 active site 693970007812 Cupin superfamily protein; Region: Cupin_4; pfam08007 693970007813 Cupin-like domain; Region: Cupin_8; pfam13621 693970007814 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 693970007815 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 693970007816 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 693970007817 NAD binding site [chemical binding]; other site 693970007818 Phe binding site; other site 693970007819 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693970007820 MarR family; Region: MarR; pfam01047 693970007821 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 693970007822 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 693970007823 FAD binding domain; Region: FAD_binding_4; pfam01565 693970007824 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693970007825 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 693970007826 phosphoenolpyruvate synthase; Validated; Region: PRK06464 693970007827 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 693970007828 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693970007829 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693970007830 PEP synthetase regulatory protein; Provisional; Region: PRK05339 693970007831 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 693970007832 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 693970007833 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 693970007834 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 693970007835 aromatic chitin/cellulose binding site residues [chemical binding]; other site 693970007836 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 693970007837 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 693970007838 active site 693970007839 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 693970007840 Chitinase C; Region: ChiC; pfam06483 693970007841 Cellulose-binding domain, chitinase and related proteins; Region: CBD_like; cd12204 693970007842 aromatic chitin/cellulose binding site residues [chemical binding]; other site 693970007843 ligand binding site [chemical binding]; other site 693970007844 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 693970007845 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693970007846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970007847 active site 693970007848 phosphorylation site [posttranslational modification] 693970007849 intermolecular recognition site; other site 693970007850 dimerization interface [polypeptide binding]; other site 693970007851 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693970007852 DNA binding residues [nucleotide binding] 693970007853 dimerization interface [polypeptide binding]; other site 693970007854 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 693970007855 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970007856 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 693970007857 substrate binding site [chemical binding]; other site 693970007858 dimerization interface [polypeptide binding]; other site 693970007859 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 693970007860 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 693970007861 active site 693970007862 interdomain interaction site; other site 693970007863 putative metal-binding site [ion binding]; other site 693970007864 nucleotide binding site [chemical binding]; other site 693970007865 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 693970007866 domain I; other site 693970007867 DNA binding groove [nucleotide binding] 693970007868 phosphate binding site [ion binding]; other site 693970007869 domain II; other site 693970007870 domain III; other site 693970007871 nucleotide binding site [chemical binding]; other site 693970007872 catalytic site [active] 693970007873 domain IV; other site 693970007874 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693970007875 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693970007876 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 693970007877 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 693970007878 succinylarginine dihydrolase; Provisional; Region: PRK13281 693970007879 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 693970007880 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693970007881 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 693970007882 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 693970007883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970007884 active site 693970007885 phosphorylation site [posttranslational modification] 693970007886 intermolecular recognition site; other site 693970007887 dimerization interface [polypeptide binding]; other site 693970007888 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693970007889 DNA binding site [nucleotide binding] 693970007890 sensor protein PhoQ; Provisional; Region: PRK10815 693970007891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970007892 ATP binding site [chemical binding]; other site 693970007893 Mg2+ binding site [ion binding]; other site 693970007894 G-X-G motif; other site 693970007895 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 693970007896 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 693970007897 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693970007898 Zn2+ binding site [ion binding]; other site 693970007899 Mg2+ binding site [ion binding]; other site 693970007900 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 693970007901 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 693970007902 Cl binding site [ion binding]; other site 693970007903 oligomer interface [polypeptide binding]; other site 693970007904 AAA domain; Region: AAA_33; pfam13671 693970007905 NAD-dependent deacetylase; Provisional; Region: PRK00481 693970007906 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 693970007907 NAD+ binding site [chemical binding]; other site 693970007908 substrate binding site [chemical binding]; other site 693970007909 Zn binding site [ion binding]; other site 693970007910 ferric uptake regulator; Provisional; Region: fur; PRK09462 693970007911 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 693970007912 metal binding site 2 [ion binding]; metal-binding site 693970007913 putative DNA binding helix; other site 693970007914 metal binding site 1 [ion binding]; metal-binding site 693970007915 dimer interface [polypeptide binding]; other site 693970007916 structural Zn2+ binding site [ion binding]; other site 693970007917 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693970007918 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693970007919 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 693970007920 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693970007921 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 693970007922 CoA binding domain; Region: CoA_binding; pfam02629 693970007923 CoA-ligase; Region: Ligase_CoA; pfam00549 693970007924 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 693970007925 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 693970007926 CoA-ligase; Region: Ligase_CoA; pfam00549 693970007927 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 693970007928 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693970007929 E3 interaction surface; other site 693970007930 lipoyl attachment site [posttranslational modification]; other site 693970007931 e3 binding domain; Region: E3_binding; pfam02817 693970007932 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693970007933 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 693970007934 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 693970007935 TPP-binding site [chemical binding]; other site 693970007936 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 693970007937 PYR/PP interface [polypeptide binding]; other site 693970007938 dimer interface [polypeptide binding]; other site 693970007939 TPP binding site [chemical binding]; other site 693970007940 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 693970007941 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 693970007942 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 693970007943 L-aspartate oxidase; Provisional; Region: PRK06175 693970007944 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 693970007945 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 693970007946 SdhC subunit interface [polypeptide binding]; other site 693970007947 proximal heme binding site [chemical binding]; other site 693970007948 cardiolipin binding site; other site 693970007949 Iron-sulfur protein interface; other site 693970007950 proximal quinone binding site [chemical binding]; other site 693970007951 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 693970007952 Iron-sulfur protein interface; other site 693970007953 proximal quinone binding site [chemical binding]; other site 693970007954 SdhD (CybS) interface [polypeptide binding]; other site 693970007955 proximal heme binding site [chemical binding]; other site 693970007956 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 693970007957 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 693970007958 dimer interface [polypeptide binding]; other site 693970007959 active site 693970007960 citrylCoA binding site [chemical binding]; other site 693970007961 NADH binding [chemical binding]; other site 693970007962 cationic pore residues; other site 693970007963 oxalacetate/citrate binding site [chemical binding]; other site 693970007964 coenzyme A binding site [chemical binding]; other site 693970007965 catalytic triad [active] 693970007966 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693970007967 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693970007968 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970007969 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693970007970 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693970007971 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 693970007972 Protein of unknown function (DUF2986); Region: DUF2986; pfam11661 693970007973 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693970007974 putative efflux protein, MATE family; Region: matE; TIGR00797 693970007975 Ion transport protein; Region: Ion_trans; pfam00520 693970007976 Ion channel; Region: Ion_trans_2; pfam07885 693970007977 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693970007978 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 693970007979 putative metal binding site [ion binding]; other site 693970007980 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693970007981 Peptidase family M23; Region: Peptidase_M23; pfam01551 693970007982 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 693970007983 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 693970007984 Nucleoid-associated protein [General function prediction only]; Region: COG3081 693970007985 nucleoid-associated protein NdpA; Validated; Region: PRK00378 693970007986 hypothetical protein; Provisional; Region: PRK13689 693970007987 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 693970007988 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 693970007989 Sulfatase; Region: Sulfatase; cl17466 693970007990 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693970007991 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 693970007992 active site 693970007993 FMN binding site [chemical binding]; other site 693970007994 substrate binding site [chemical binding]; other site 693970007995 homotetramer interface [polypeptide binding]; other site 693970007996 catalytic residue [active] 693970007997 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970007998 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970007999 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693970008000 dimerization interface [polypeptide binding]; other site 693970008001 hypothetical protein; Provisional; Region: PRK02135 693970008002 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 693970008003 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970008004 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970008005 metal binding site [ion binding]; metal-binding site 693970008006 active site 693970008007 I-site; other site 693970008008 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693970008009 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 693970008010 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 693970008011 homodimer interface [polypeptide binding]; other site 693970008012 NAD binding pocket [chemical binding]; other site 693970008013 ATP binding pocket [chemical binding]; other site 693970008014 Mg binding site [ion binding]; other site 693970008015 active-site loop [active] 693970008016 inosine/guanosine kinase; Provisional; Region: PRK15074 693970008017 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693970008018 substrate binding site [chemical binding]; other site 693970008019 ATP binding site [chemical binding]; other site 693970008020 ferrochelatase; Reviewed; Region: hemH; PRK00035 693970008021 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 693970008022 C-terminal domain interface [polypeptide binding]; other site 693970008023 active site 693970008024 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 693970008025 active site 693970008026 N-terminal domain interface [polypeptide binding]; other site 693970008027 adenylate kinase; Reviewed; Region: adk; PRK00279 693970008028 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 693970008029 AMP-binding site [chemical binding]; other site 693970008030 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 693970008031 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 693970008032 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 693970008033 heat shock protein 90; Provisional; Region: PRK05218 693970008034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970008035 ATP binding site [chemical binding]; other site 693970008036 Mg2+ binding site [ion binding]; other site 693970008037 G-X-G motif; other site 693970008038 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693970008039 Protein export membrane protein; Region: SecD_SecF; cl14618 693970008040 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693970008041 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693970008042 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970008043 lipoprotein; Provisional; Region: PRK11679 693970008044 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 693970008045 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 693970008046 dihydrodipicolinate synthase; Region: dapA; TIGR00674 693970008047 dimer interface [polypeptide binding]; other site 693970008048 active site 693970008049 catalytic residue [active] 693970008050 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 693970008051 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 693970008052 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 693970008053 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 693970008054 catalytic triad [active] 693970008055 Lysine efflux permease [General function prediction only]; Region: COG1279 693970008056 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 693970008057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970008058 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 693970008059 putative dimerization interface [polypeptide binding]; other site 693970008060 heat shock protein HtpX; Provisional; Region: PRK05457 693970008061 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 693970008062 active site pocket [active] 693970008063 oxyanion hole [active] 693970008064 catalytic triad [active] 693970008065 active site nucleophile [active] 693970008066 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 693970008067 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 693970008068 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 693970008069 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 693970008070 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 693970008071 GIY-YIG motif/motif A; other site 693970008072 active site 693970008073 catalytic site [active] 693970008074 putative DNA binding site [nucleotide binding]; other site 693970008075 metal binding site [ion binding]; metal-binding site 693970008076 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 693970008077 Cache domain; Region: Cache_1; pfam02743 693970008078 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 693970008079 dimerization interface [polypeptide binding]; other site 693970008080 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693970008081 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970008082 dimer interface [polypeptide binding]; other site 693970008083 putative CheW interface [polypeptide binding]; other site 693970008084 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 693970008085 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 693970008086 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 693970008087 active site 1 [active] 693970008088 dimer interface [polypeptide binding]; other site 693970008089 active site 2 [active] 693970008090 ribosome modulation factor; Provisional; Region: PRK14563 693970008091 Protein of unknown function (DUF3466); Region: DUF3466; pfam11949 693970008092 ABC transporter ATPase component; Reviewed; Region: PRK11147 693970008093 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693970008094 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693970008095 ABC transporter; Region: ABC_tran_2; pfam12848 693970008096 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693970008097 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 693970008098 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 693970008099 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 693970008100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970008101 S-adenosylmethionine binding site [chemical binding]; other site 693970008102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970008103 S-adenosylmethionine binding site [chemical binding]; other site 693970008104 putative acetyltransferase YhhY; Provisional; Region: PRK10140 693970008105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970008106 Coenzyme A binding pocket [chemical binding]; other site 693970008107 recombination protein RecR; Reviewed; Region: recR; PRK00076 693970008108 RecR protein; Region: RecR; pfam02132 693970008109 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 693970008110 putative active site [active] 693970008111 putative metal-binding site [ion binding]; other site 693970008112 tetramer interface [polypeptide binding]; other site 693970008113 hypothetical protein; Validated; Region: PRK00153 693970008114 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14949 693970008115 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970008116 Walker A motif; other site 693970008117 ATP binding site [chemical binding]; other site 693970008118 Walker B motif; other site 693970008119 DNA polymerase III subunit delta'; Validated; Region: PRK08485 693970008120 arginine finger; other site 693970008121 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 693970008122 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 693970008123 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693970008124 active site 693970008125 hypothetical protein; Provisional; Region: PRK10527 693970008126 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 693970008127 hypothetical protein; Provisional; Region: PRK05409 693970008128 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 693970008129 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 693970008130 FMN binding site [chemical binding]; other site 693970008131 active site 693970008132 catalytic residues [active] 693970008133 substrate binding site [chemical binding]; other site 693970008134 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 693970008135 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 693970008136 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 693970008137 active site 693970008138 metal binding site [ion binding]; metal-binding site 693970008139 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 693970008140 Transposase; Region: HTH_Tnp_1; cl17663 693970008141 Winged helix-turn helix; Region: HTH_29; pfam13551 693970008142 Homeodomain-like domain; Region: HTH_32; pfam13565 693970008143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970008144 Integrase core domain; Region: rve; pfam00665 693970008145 Integrase core domain; Region: rve_3; pfam13683 693970008146 Protein of unknown function (DUF3389); Region: DUF3389; pfam11869 693970008147 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 693970008148 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 693970008149 active site 693970008150 Zn binding site [ion binding]; other site 693970008151 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 693970008152 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 693970008153 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693970008154 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 693970008155 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 693970008156 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693970008157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970008158 active site 693970008159 phosphorylation site [posttranslational modification] 693970008160 intermolecular recognition site; other site 693970008161 dimerization interface [polypeptide binding]; other site 693970008162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970008163 S-adenosylmethionine binding site [chemical binding]; other site 693970008164 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 693970008165 RNA polymerase sigma factor; Provisional; Region: PRK11924 693970008166 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693970008167 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693970008168 DNA binding residues [nucleotide binding] 693970008169 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 693970008170 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 693970008171 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 693970008172 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 693970008173 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693970008174 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862 693970008175 putative active site [active] 693970008176 Zn binding site [ion binding]; other site 693970008177 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693970008178 membrane-bound complex binding site; other site 693970008179 hinge residues; other site 693970008180 AMP-binding domain protein; Validated; Region: PRK08315 693970008181 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693970008182 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 693970008183 acyl-activating enzyme (AAE) consensus motif; other site 693970008184 putative AMP binding site [chemical binding]; other site 693970008185 putative active site [active] 693970008186 putative CoA binding site [chemical binding]; other site 693970008187 Uncharacterized conserved protein [Function unknown]; Region: COG2947 693970008188 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 693970008189 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693970008190 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 693970008191 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693970008192 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 693970008193 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970008194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970008195 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693970008196 dimerization interface [polypeptide binding]; other site 693970008197 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 693970008198 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 693970008199 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 693970008200 dimer interface [polypeptide binding]; other site 693970008201 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 693970008202 active site 693970008203 Fe binding site [ion binding]; other site 693970008204 maltose O-acetyltransferase; Provisional; Region: PRK10092 693970008205 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 693970008206 active site 693970008207 substrate binding site [chemical binding]; other site 693970008208 trimer interface [polypeptide binding]; other site 693970008209 CoA binding site [chemical binding]; other site 693970008210 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693970008211 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 693970008212 Protein of unknown function, DUF482; Region: DUF482; pfam04339 693970008213 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 693970008214 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 693970008215 Winged helix-turn helix; Region: HTH_29; pfam13551 693970008216 Homeodomain-like domain; Region: HTH_32; pfam13565 693970008217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970008218 Integrase core domain; Region: rve; pfam00665 693970008219 Integrase core domain; Region: rve_3; pfam13683 693970008220 Transposase; Region: HTH_Tnp_1; cl17663 693970008221 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 693970008222 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 693970008223 active site 693970008224 Zn binding site [ion binding]; other site 693970008225 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693970008226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970008227 Coenzyme A binding pocket [chemical binding]; other site 693970008228 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 693970008229 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 693970008230 active site 693970008231 Zn binding site [ion binding]; other site 693970008232 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 693970008233 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 693970008234 active site 693970008235 metal binding site [ion binding]; metal-binding site 693970008236 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 693970008237 hypothetical protein; Provisional; Region: PRK03641 693970008238 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829 693970008239 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 693970008240 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693970008241 active site 693970008242 motif I; other site 693970008243 motif II; other site 693970008244 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693970008245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693970008246 DNA-binding site [nucleotide binding]; DNA binding site 693970008247 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693970008248 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 693970008249 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 693970008250 dimer interface [polypeptide binding]; other site 693970008251 active site 693970008252 CoA binding pocket [chemical binding]; other site 693970008253 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 693970008254 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 693970008255 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 693970008256 active site 693970008257 catalytic site [active] 693970008258 substrate binding site [chemical binding]; other site 693970008259 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 693970008260 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 693970008261 ligand binding site [chemical binding]; other site 693970008262 flexible hinge region; other site 693970008263 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 693970008264 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 693970008265 metal binding triad; other site 693970008266 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 693970008267 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 693970008268 Na binding site [ion binding]; other site 693970008269 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 693970008270 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 693970008271 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 693970008272 catalytic residues [active] 693970008273 hinge region; other site 693970008274 alpha helical domain; other site 693970008275 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 693970008276 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693970008277 putative NAD(P) binding site [chemical binding]; other site 693970008278 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 693970008279 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693970008280 Zn2+ binding site [ion binding]; other site 693970008281 Mg2+ binding site [ion binding]; other site 693970008282 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 693970008283 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 693970008284 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970008285 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970008286 Integrase core domain; Region: rve; pfam00665 693970008287 Transposase; Region: HTH_Tnp_1; pfam01527 693970008288 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970008289 putative transposase OrfB; Reviewed; Region: PHA02517 693970008290 HTH-like domain; Region: HTH_21; pfam13276 693970008291 Integrase core domain; Region: rve; pfam00665 693970008292 Integrase core domain; Region: rve_2; pfam13333 693970008293 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 693970008294 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 693970008295 nucleotide binding pocket [chemical binding]; other site 693970008296 K-X-D-G motif; other site 693970008297 catalytic site [active] 693970008298 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 693970008299 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 693970008300 Dimer interface [polypeptide binding]; other site 693970008301 BRCT sequence motif; other site 693970008302 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 693970008303 K-X-D-G motif; other site 693970008304 catalytic site [active] 693970008305 cell division protein ZipA; Provisional; Region: PRK03427 693970008306 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 693970008307 FtsZ protein binding site [polypeptide binding]; other site 693970008308 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 693970008309 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 693970008310 Walker A/P-loop; other site 693970008311 ATP binding site [chemical binding]; other site 693970008312 Q-loop/lid; other site 693970008313 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 693970008314 ABC transporter signature motif; other site 693970008315 Walker B; other site 693970008316 D-loop; other site 693970008317 H-loop/switch region; other site 693970008318 putative sulfate transport protein CysZ; Validated; Region: PRK04949 693970008319 Transposase; Region: HTH_Tnp_1; pfam01527 693970008320 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970008321 putative transposase OrfB; Reviewed; Region: PHA02517 693970008322 HTH-like domain; Region: HTH_21; pfam13276 693970008323 Integrase core domain; Region: rve; pfam00665 693970008324 Integrase core domain; Region: rve_2; pfam13333 693970008325 RDD family; Region: RDD; pfam06271 693970008326 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 693970008327 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 693970008328 dimer interface [polypeptide binding]; other site 693970008329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970008330 catalytic residue [active] 693970008331 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 693970008332 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 693970008333 gating phenylalanine in ion channel; other site 693970008334 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970008335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970008336 Walker A motif; other site 693970008337 ATP binding site [chemical binding]; other site 693970008338 Walker B motif; other site 693970008339 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 693970008340 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693970008341 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 693970008342 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 693970008343 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 693970008344 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693970008345 formate transporter FocA; Region: formate_focA; TIGR04060 693970008346 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 693970008347 Pyruvate formate lyase 1; Region: PFL1; cd01678 693970008348 coenzyme A binding site [chemical binding]; other site 693970008349 active site 693970008350 catalytic residues [active] 693970008351 glycine loop; other site 693970008352 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 693970008353 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693970008354 FeS/SAM binding site; other site 693970008355 Protein of unknown function, DUF412; Region: DUF412; pfam04217 693970008356 propionate/acetate kinase; Provisional; Region: PRK12379 693970008357 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693970008358 nucleotide binding site [chemical binding]; other site 693970008359 butyrate kinase; Provisional; Region: PRK03011 693970008360 phosphate acetyltransferase; Reviewed; Region: PRK05632 693970008361 DRTGG domain; Region: DRTGG; pfam07085 693970008362 phosphate acetyltransferase; Region: pta; TIGR00651 693970008363 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 693970008364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970008365 S-adenosylmethionine binding site [chemical binding]; other site 693970008366 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 693970008367 Domain of unknown function DUF20; Region: UPF0118; pfam01594 693970008368 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 693970008369 homooctamer interface [polypeptide binding]; other site 693970008370 active site 693970008371 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 693970008372 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 693970008373 putative NAD(P) binding site [chemical binding]; other site 693970008374 putative active site [active] 693970008375 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 693970008376 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 693970008377 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693970008378 Catalytic site [active] 693970008379 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693970008380 FtsX-like permease family; Region: FtsX; pfam02687 693970008381 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 693970008382 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693970008383 Walker A/P-loop; other site 693970008384 ATP binding site [chemical binding]; other site 693970008385 Q-loop/lid; other site 693970008386 ABC transporter signature motif; other site 693970008387 Walker B; other site 693970008388 D-loop; other site 693970008389 H-loop/switch region; other site 693970008390 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 693970008391 active site 693970008392 catalytic triad [active] 693970008393 oxyanion hole [active] 693970008394 switch loop; other site 693970008395 Protein of unknown function (DUF3083); Region: DUF3083; pfam11281 693970008396 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 693970008397 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693970008398 Predicted integral membrane protein [Function unknown]; Region: COG0392 693970008399 Uncharacterized conserved protein [Function unknown]; Region: COG2898 693970008400 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 693970008401 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 693970008402 putative inner membrane peptidase; Provisional; Region: PRK11778 693970008403 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 693970008404 tandem repeat interface [polypeptide binding]; other site 693970008405 oligomer interface [polypeptide binding]; other site 693970008406 active site residues [active] 693970008407 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 693970008408 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 693970008409 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 693970008410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693970008411 NAD(P) binding site [chemical binding]; other site 693970008412 active site 693970008413 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 693970008414 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693970008415 RNA binding surface [nucleotide binding]; other site 693970008416 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 693970008417 probable active site [active] 693970008418 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 693970008419 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 693970008420 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 693970008421 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 693970008422 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 693970008423 active site 693970008424 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 693970008425 anthranilate synthase component I; Provisional; Region: PRK13564 693970008426 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 693970008427 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 693970008428 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 693970008429 glutamine binding [chemical binding]; other site 693970008430 catalytic triad [active] 693970008431 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 693970008432 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 693970008433 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 693970008434 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 693970008435 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 693970008436 active site 693970008437 ribulose/triose binding site [chemical binding]; other site 693970008438 phosphate binding site [ion binding]; other site 693970008439 substrate (anthranilate) binding pocket [chemical binding]; other site 693970008440 product (indole) binding pocket [chemical binding]; other site 693970008441 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 693970008442 active site 693970008443 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 693970008444 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 693970008445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970008446 catalytic residue [active] 693970008447 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 693970008448 substrate binding site [chemical binding]; other site 693970008449 active site 693970008450 catalytic residues [active] 693970008451 heterodimer interface [polypeptide binding]; other site 693970008452 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 693970008453 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 693970008454 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693970008455 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 693970008456 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 693970008457 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 693970008458 IucA / IucC family; Region: IucA_IucC; pfam04183 693970008459 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 693970008460 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 693970008461 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693970008462 N-terminal plug; other site 693970008463 ligand-binding site [chemical binding]; other site 693970008464 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 693970008465 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 693970008466 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 693970008467 intracellular septation protein A; Reviewed; Region: PRK00259 693970008468 YciI-like protein; Reviewed; Region: PRK11370 693970008469 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 693970008470 putative catalytic site [active] 693970008471 putative phosphate binding site [ion binding]; other site 693970008472 active site 693970008473 metal binding site A [ion binding]; metal-binding site 693970008474 DNA binding site [nucleotide binding] 693970008475 putative AP binding site [nucleotide binding]; other site 693970008476 putative metal binding site B [ion binding]; other site 693970008477 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 693970008478 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693970008479 Integrase core domain; Region: rve; pfam00665 693970008480 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970008481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970008482 Walker A motif; other site 693970008483 ATP binding site [chemical binding]; other site 693970008484 Walker B motif; other site 693970008485 PRC-barrel domain; Region: PRC; pfam05239 693970008486 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693970008487 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693970008488 ligand binding site [chemical binding]; other site 693970008489 flexible hinge region; other site 693970008490 non-specific DNA interactions [nucleotide binding]; other site 693970008491 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 693970008492 DNA binding site [nucleotide binding] 693970008493 sequence specific DNA binding site [nucleotide binding]; other site 693970008494 putative cAMP binding site [chemical binding]; other site 693970008495 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 693970008496 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693970008497 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 693970008498 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693970008499 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970008500 dimer interface [polypeptide binding]; other site 693970008501 putative CheW interface [polypeptide binding]; other site 693970008502 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693970008503 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693970008504 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693970008505 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693970008506 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693970008507 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 693970008508 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693970008509 catalytic loop [active] 693970008510 iron binding site [ion binding]; other site 693970008511 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693970008512 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 693970008513 Ligand binding site; other site 693970008514 metal-binding site 693970008515 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 693970008516 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 693970008517 XdhC Rossmann domain; Region: XdhC_C; pfam13478 693970008518 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693970008519 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 693970008520 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970008521 dimer interface [polypeptide binding]; other site 693970008522 putative CheW interface [polypeptide binding]; other site 693970008523 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 693970008524 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 693970008525 DNA topoisomerase III; Provisional; Region: PRK07726 693970008526 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 693970008527 active site 693970008528 putative interdomain interaction site [polypeptide binding]; other site 693970008529 putative metal-binding site [ion binding]; other site 693970008530 putative nucleotide binding site [chemical binding]; other site 693970008531 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 693970008532 domain I; other site 693970008533 DNA binding groove [nucleotide binding] 693970008534 phosphate binding site [ion binding]; other site 693970008535 domain II; other site 693970008536 domain III; other site 693970008537 nucleotide binding site [chemical binding]; other site 693970008538 catalytic site [active] 693970008539 domain IV; other site 693970008540 amidophosphoribosyltransferase; Provisional; Region: PRK09246 693970008541 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 693970008542 active site 693970008543 tetramer interface [polypeptide binding]; other site 693970008544 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693970008545 active site 693970008546 Colicin V production protein; Region: Colicin_V; cl00567 693970008547 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 693970008548 Sporulation related domain; Region: SPOR; pfam05036 693970008549 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 693970008550 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693970008551 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693970008552 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 693970008553 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 693970008554 dimerization interface 3.5A [polypeptide binding]; other site 693970008555 active site 693970008556 FimV N-terminal domain; Region: FimV_core; TIGR03505 693970008557 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 693970008558 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 693970008559 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 693970008560 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 693970008561 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 693970008562 ligand binding site [chemical binding]; other site 693970008563 NAD binding site [chemical binding]; other site 693970008564 catalytic site [active] 693970008565 homodimer interface [polypeptide binding]; other site 693970008566 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 693970008567 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693970008568 dimer interface [polypeptide binding]; other site 693970008569 active site 693970008570 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 693970008571 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 693970008572 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 693970008573 YfcL protein; Region: YfcL; pfam08891 693970008574 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 693970008575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970008576 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 693970008577 putative substrate translocation pore; other site 693970008578 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 693970008579 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 693970008580 Tetramer interface [polypeptide binding]; other site 693970008581 active site 693970008582 FMN-binding site [chemical binding]; other site 693970008583 HemK family putative methylases; Region: hemK_fam; TIGR00536 693970008584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970008585 S-adenosylmethionine binding site [chemical binding]; other site 693970008586 hypothetical protein; Provisional; Region: PRK04946 693970008587 Smr domain; Region: Smr; pfam01713 693970008588 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693970008589 catalytic core [active] 693970008590 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 693970008591 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693970008592 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693970008593 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693970008594 Two component regulator propeller; Region: Reg_prop; pfam07494 693970008595 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 693970008596 PAS fold; Region: PAS_3; pfam08447 693970008597 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970008598 PAS domain; Region: PAS_9; pfam13426 693970008599 putative active site [active] 693970008600 heme pocket [chemical binding]; other site 693970008601 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970008602 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970008603 metal binding site [ion binding]; metal-binding site 693970008604 active site 693970008605 I-site; other site 693970008606 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970008607 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970008608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970008609 Walker A motif; other site 693970008610 ATP binding site [chemical binding]; other site 693970008611 Walker B motif; other site 693970008612 Integrase core domain; Region: rve; pfam00665 693970008613 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 693970008614 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693970008615 substrate binding site [chemical binding]; other site 693970008616 oxyanion hole (OAH) forming residues; other site 693970008617 trimer interface [polypeptide binding]; other site 693970008618 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693970008619 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693970008620 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693970008621 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 693970008622 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693970008623 dimer interface [polypeptide binding]; other site 693970008624 active site 693970008625 MoxR-like ATPases [General function prediction only]; Region: COG0714 693970008626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970008627 Walker A motif; other site 693970008628 ATP binding site [chemical binding]; other site 693970008629 Walker B motif; other site 693970008630 arginine finger; other site 693970008631 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 693970008632 Protein of unknown function DUF58; Region: DUF58; pfam01882 693970008633 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 693970008634 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 693970008635 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 693970008636 metal ion-dependent adhesion site (MIDAS); other site 693970008637 von Willebrand factor type A domain; Region: VWA_2; pfam13519 693970008638 metal ion-dependent adhesion site (MIDAS); other site 693970008639 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 693970008640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970008641 binding surface 693970008642 TPR motif; other site 693970008643 Oxygen tolerance; Region: BatD; pfam13584 693970008644 RNA polymerase sigma factor; Provisional; Region: PRK12517 693970008645 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693970008646 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693970008647 DNA binding residues [nucleotide binding] 693970008648 Protein of unknown function (DUF3379); Region: DUF3379; pfam11859 693970008649 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 693970008650 Na binding site [ion binding]; other site 693970008651 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 693970008652 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 693970008653 active site 693970008654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 693970008655 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693970008656 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693970008657 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970008658 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693970008659 Protein export membrane protein; Region: SecD_SecF; cl14618 693970008660 Protein export membrane protein; Region: SecD_SecF; cl14618 693970008661 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 693970008662 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 693970008663 active site residue [active] 693970008664 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693970008665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970008666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693970008667 Coenzyme A binding pocket [chemical binding]; other site 693970008668 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 693970008669 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 693970008670 active site 693970008671 catalytic residues [active] 693970008672 PA_VapT_like: Protease-associated domain containing proteins like VapT from Vibrio metschnikovii strain RH530. This group contains various PA domain-containing proteins similar to V. metschnikovii VapT, including the serine alkaline protease SapSh from...; Region: PA_VapT_like; cd04817 693970008673 PA/subtilisin-like domain interface [polypeptide binding]; other site 693970008674 Subtilase family; Region: Peptidase_S8; pfam00082 693970008675 catalytic residues [active] 693970008676 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693970008677 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 693970008678 YaeQ protein; Region: YaeQ; pfam07152 693970008679 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 693970008680 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 693970008681 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 693970008682 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 693970008683 active site residue [active] 693970008684 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 693970008685 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 693970008686 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 693970008687 Protein export membrane protein; Region: SecD_SecF; pfam02355 693970008688 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 693970008689 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 693970008690 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 693970008691 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 693970008692 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 693970008693 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 693970008694 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 693970008695 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 693970008696 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 693970008697 Protein of unknown function, DUF479; Region: DUF479; pfam04336 693970008698 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693970008699 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693970008700 active site 693970008701 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693970008702 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 693970008703 serine/threonine transporter SstT; Provisional; Region: PRK13628 693970008704 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693970008705 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 693970008706 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693970008707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970008708 active site 693970008709 phosphorylation site [posttranslational modification] 693970008710 intermolecular recognition site; other site 693970008711 dimerization interface [polypeptide binding]; other site 693970008712 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 693970008713 active site 693970008714 catalytic residues [active] 693970008715 helicase 45; Provisional; Region: PTZ00424 693970008716 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693970008717 ATP binding site [chemical binding]; other site 693970008718 Mg++ binding site [ion binding]; other site 693970008719 motif III; other site 693970008720 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970008721 nucleotide binding region [chemical binding]; other site 693970008722 ATP-binding site [chemical binding]; other site 693970008723 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 693970008724 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 693970008725 DNA binding site [nucleotide binding] 693970008726 active site 693970008727 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 693970008728 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 693970008729 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693970008730 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693970008731 AlkA N-terminal domain; Region: AlkA_N; pfam06029 693970008732 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 693970008733 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693970008734 minor groove reading motif; other site 693970008735 helix-hairpin-helix signature motif; other site 693970008736 substrate binding pocket [chemical binding]; other site 693970008737 active site 693970008738 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693970008739 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693970008740 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 693970008741 Walker A/P-loop; other site 693970008742 ATP binding site [chemical binding]; other site 693970008743 Q-loop/lid; other site 693970008744 ABC transporter signature motif; other site 693970008745 Walker B; other site 693970008746 D-loop; other site 693970008747 H-loop/switch region; other site 693970008748 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 693970008749 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 693970008750 active site 693970008751 HIGH motif; other site 693970008752 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 693970008753 active site 693970008754 KMSKS motif; other site 693970008755 Integrase core domain; Region: rve; pfam00665 693970008756 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970008757 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970008758 Walker A motif; other site 693970008759 ATP binding site [chemical binding]; other site 693970008760 Walker B motif; other site 693970008761 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 693970008762 DctM-like transporters; Region: DctM; pfam06808 693970008763 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693970008764 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 693970008765 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970008766 dimer interface [polypeptide binding]; other site 693970008767 phosphorylation site [posttranslational modification] 693970008768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970008769 ATP binding site [chemical binding]; other site 693970008770 Mg2+ binding site [ion binding]; other site 693970008771 G-X-G motif; other site 693970008772 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 693970008773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970008774 active site 693970008775 phosphorylation site [posttranslational modification] 693970008776 intermolecular recognition site; other site 693970008777 dimerization interface [polypeptide binding]; other site 693970008778 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970008779 Walker A motif; other site 693970008780 ATP binding site [chemical binding]; other site 693970008781 Walker B motif; other site 693970008782 arginine finger; other site 693970008783 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693970008784 Protein of unknown function, DUF606; Region: DUF606; pfam04657 693970008785 Protein of unknown function, DUF606; Region: DUF606; pfam04657 693970008786 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970008787 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970008788 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693970008789 putative effector binding pocket; other site 693970008790 dimerization interface [polypeptide binding]; other site 693970008791 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693970008792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970008793 putative substrate translocation pore; other site 693970008794 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970008795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970008796 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693970008797 dimerization interface [polypeptide binding]; other site 693970008798 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 693970008799 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 693970008800 active site 693970008801 catalytic triad [active] 693970008802 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 693970008803 PA/protease or protease-like domain interface [polypeptide binding]; other site 693970008804 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 693970008805 catalytic residues [active] 693970008806 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693970008807 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 693970008808 acyl-CoA thioesterase II; Provisional; Region: PRK10526 693970008809 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 693970008810 active site 693970008811 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 693970008812 catalytic triad [active] 693970008813 dimer interface [polypeptide binding]; other site 693970008814 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 693970008815 classical (c) SDRs; Region: SDR_c; cd05233 693970008816 NAD(P) binding site [chemical binding]; other site 693970008817 active site 693970008818 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 693970008819 UbiA prenyltransferase family; Region: UbiA; pfam01040 693970008820 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 693970008821 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 693970008822 putative active site [active] 693970008823 metal binding site [ion binding]; metal-binding site 693970008824 DoxX-like family; Region: DoxX_2; pfam13564 693970008825 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970008826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970008827 LysR substrate binding domain; Region: LysR_substrate; pfam03466 693970008828 dimerization interface [polypeptide binding]; other site 693970008829 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 693970008830 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 693970008831 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 693970008832 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 693970008833 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 693970008834 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693970008835 acyl-activating enzyme (AAE) consensus motif; other site 693970008836 AMP binding site [chemical binding]; other site 693970008837 active site 693970008838 CoA binding site [chemical binding]; other site 693970008839 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693970008840 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 693970008841 DNA binding residues [nucleotide binding] 693970008842 putative dimer interface [polypeptide binding]; other site 693970008843 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 693970008844 isovaleryl-CoA dehydrogenase; Region: PLN02519 693970008845 substrate binding site [chemical binding]; other site 693970008846 FAD binding site [chemical binding]; other site 693970008847 catalytic base [active] 693970008848 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 693970008849 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 693970008850 enoyl-CoA hydratase; Provisional; Region: PRK05995 693970008851 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693970008852 substrate binding site [chemical binding]; other site 693970008853 oxyanion hole (OAH) forming residues; other site 693970008854 trimer interface [polypeptide binding]; other site 693970008855 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 693970008856 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693970008857 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 693970008858 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 693970008859 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693970008860 carboxyltransferase (CT) interaction site; other site 693970008861 biotinylation site [posttranslational modification]; other site 693970008862 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 693970008863 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 693970008864 active site 693970008865 catalytic residues [active] 693970008866 metal binding site [ion binding]; metal-binding site 693970008867 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 693970008868 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 693970008869 Putative amidotransferase; Region: DUF4066; pfam13278 693970008870 conserved cys residue [active] 693970008871 hypothetical protein; Provisional; Region: PRK10621 693970008872 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693970008873 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 693970008874 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 693970008875 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 693970008876 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 693970008877 Transglycosylase; Region: Transgly; cl17702 693970008878 thymidine kinase; Provisional; Region: PRK04296 693970008879 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 693970008880 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 693970008881 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 693970008882 active site 693970008883 Zn binding site [ion binding]; other site 693970008884 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 693970008885 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 693970008886 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 693970008887 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 693970008888 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 693970008889 Ligand binding site [chemical binding]; other site 693970008890 Electron transfer flavoprotein domain; Region: ETF; pfam01012 693970008891 H-NS histone family; Region: Histone_HNS; pfam00816 693970008892 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 693970008893 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970008894 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970008895 Integrase core domain; Region: rve; pfam00665 693970008896 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 693970008897 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 693970008898 homodimer interaction site [polypeptide binding]; other site 693970008899 cofactor binding site; other site 693970008900 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 693970008901 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 693970008902 putative CoA binding site [chemical binding]; other site 693970008903 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 693970008904 trimer interface [polypeptide binding]; other site 693970008905 active site 693970008906 substrate binding site [chemical binding]; other site 693970008907 CoA binding site [chemical binding]; other site 693970008908 prolyl-tRNA synthetase; Provisional; Region: PRK09194 693970008909 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 693970008910 dimer interface [polypeptide binding]; other site 693970008911 motif 1; other site 693970008912 active site 693970008913 motif 2; other site 693970008914 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 693970008915 putative deacylase active site [active] 693970008916 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 693970008917 active site 693970008918 motif 3; other site 693970008919 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 693970008920 anticodon binding site; other site 693970008921 Cupin domain; Region: Cupin_2; cl17218 693970008922 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693970008923 Helix-turn-helix domain; Region: HTH_18; pfam12833 693970008924 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 693970008925 active site 693970008926 oligomerization interface [polypeptide binding]; other site 693970008927 metal binding site [ion binding]; metal-binding site 693970008928 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 693970008929 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 693970008930 nucleophile elbow; other site 693970008931 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 693970008932 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 693970008933 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 693970008934 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693970008935 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 693970008936 active site 693970008937 FMN binding site [chemical binding]; other site 693970008938 substrate binding site [chemical binding]; other site 693970008939 homotetramer interface [polypeptide binding]; other site 693970008940 catalytic residue [active] 693970008941 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 693970008942 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 693970008943 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 693970008944 substrate binding site; other site 693970008945 tetramer interface; other site 693970008946 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693970008947 GAF domain; Region: GAF; pfam01590 693970008948 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693970008949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970008950 ATP binding site [chemical binding]; other site 693970008951 Mg2+ binding site [ion binding]; other site 693970008952 G-X-G motif; other site 693970008953 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693970008954 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 693970008955 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 693970008956 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693970008957 Zn2+ binding site [ion binding]; other site 693970008958 Mg2+ binding site [ion binding]; other site 693970008959 NlpE N-terminal domain; Region: NlpE; pfam04170 693970008960 HutD; Region: HutD; pfam05962 693970008961 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970008962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970008963 Walker A motif; other site 693970008964 ATP binding site [chemical binding]; other site 693970008965 Walker B motif; other site 693970008966 Integrase core domain; Region: rve; pfam00665 693970008967 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 693970008968 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 693970008969 active site 693970008970 substrate binding site [chemical binding]; other site 693970008971 metal binding site [ion binding]; metal-binding site 693970008972 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 693970008973 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 693970008974 NAD(P) binding site [chemical binding]; other site 693970008975 homodimer interface [polypeptide binding]; other site 693970008976 substrate binding site [chemical binding]; other site 693970008977 active site 693970008978 Bacterial sugar transferase; Region: Bac_transf; pfam02397 693970008979 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693970008980 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 693970008981 putative NAD(P) binding site [chemical binding]; other site 693970008982 active site 693970008983 putative substrate binding site [chemical binding]; other site 693970008984 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 693970008985 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693970008986 active site 693970008987 putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ; Provisional; Region: PRK09677 693970008988 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 693970008989 trimer interface [polypeptide binding]; other site 693970008990 active site 693970008991 substrate binding site [chemical binding]; other site 693970008992 CoA binding site [chemical binding]; other site 693970008993 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693970008994 active site 693970008995 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693970008996 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 693970008997 putative ADP-binding pocket [chemical binding]; other site 693970008998 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 693970008999 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 693970009000 Probable Catalytic site; other site 693970009001 metal-binding site 693970009002 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693970009003 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693970009004 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693970009005 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 693970009006 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 693970009007 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 693970009008 NADP binding site [chemical binding]; other site 693970009009 active site 693970009010 putative substrate binding site [chemical binding]; other site 693970009011 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 693970009012 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 693970009013 substrate binding site; other site 693970009014 tetramer interface; other site 693970009015 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 693970009016 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 693970009017 NAD binding site [chemical binding]; other site 693970009018 substrate binding site [chemical binding]; other site 693970009019 homodimer interface [polypeptide binding]; other site 693970009020 active site 693970009021 Chain length determinant protein; Region: Wzz; pfam02706 693970009022 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 693970009023 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 693970009024 SLBB domain; Region: SLBB; pfam10531 693970009025 SLBB domain; Region: SLBB; pfam10531 693970009026 SLBB domain; Region: SLBB; pfam10531 693970009027 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 693970009028 SLBB domain; Region: SLBB; pfam10531 693970009029 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 693970009030 transcriptional activator RfaH; Region: RfaH; TIGR01955 693970009031 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 693970009032 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 693970009033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970009034 putative substrate translocation pore; other site 693970009035 Response regulator receiver domain; Region: Response_reg; pfam00072 693970009036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970009037 active site 693970009038 phosphorylation site [posttranslational modification] 693970009039 intermolecular recognition site; other site 693970009040 dimerization interface [polypeptide binding]; other site 693970009041 VacJ like lipoprotein; Region: VacJ; cl01073 693970009042 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 693970009043 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 693970009044 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 693970009045 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 693970009046 putative CheA interaction surface; other site 693970009047 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 693970009048 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693970009049 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693970009050 P-loop; other site 693970009051 Magnesium ion binding site [ion binding]; other site 693970009052 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693970009053 Magnesium ion binding site [ion binding]; other site 693970009054 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 693970009055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970009056 active site 693970009057 phosphorylation site [posttranslational modification] 693970009058 intermolecular recognition site; other site 693970009059 CheB methylesterase; Region: CheB_methylest; pfam01339 693970009060 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693970009061 putative binding surface; other site 693970009062 active site 693970009063 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 693970009064 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 693970009065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970009066 ATP binding site [chemical binding]; other site 693970009067 Mg2+ binding site [ion binding]; other site 693970009068 G-X-G motif; other site 693970009069 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 693970009070 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 693970009071 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 693970009072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970009073 active site 693970009074 phosphorylation site [posttranslational modification] 693970009075 intermolecular recognition site; other site 693970009076 dimerization interface [polypeptide binding]; other site 693970009077 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 693970009078 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693970009079 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693970009080 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693970009081 DNA binding residues [nucleotide binding] 693970009082 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693970009083 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 693970009084 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 693970009085 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 693970009086 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693970009087 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 693970009088 FHIPEP family; Region: FHIPEP; pfam00771 693970009089 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 693970009090 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 693970009091 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 693970009092 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 693970009093 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 693970009094 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 693970009095 flagellar motor switch protein; Validated; Region: fliN; PRK08983 693970009096 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 693970009097 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 693970009098 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696 693970009099 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 693970009100 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 693970009101 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 693970009102 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08972 693970009103 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 693970009104 Walker A motif/ATP binding site; other site 693970009105 Walker B motif; other site 693970009106 flagellar assembly protein H; Validated; Region: fliH; PRK05687 693970009107 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 693970009108 Flagellar assembly protein FliH; Region: FliH; pfam02108 693970009109 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 693970009110 MgtE intracellular N domain; Region: MgtE_N; smart00924 693970009111 FliG C-terminal domain; Region: FliG_C; pfam01706 693970009112 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 693970009113 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 693970009114 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 693970009115 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 693970009116 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 693970009117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970009118 active site 693970009119 phosphorylation site [posttranslational modification] 693970009120 intermolecular recognition site; other site 693970009121 dimerization interface [polypeptide binding]; other site 693970009122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970009123 Walker A motif; other site 693970009124 ATP binding site [chemical binding]; other site 693970009125 Walker B motif; other site 693970009126 arginine finger; other site 693970009127 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693970009128 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 693970009129 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970009130 putative active site [active] 693970009131 heme pocket [chemical binding]; other site 693970009132 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970009133 dimer interface [polypeptide binding]; other site 693970009134 phosphorylation site [posttranslational modification] 693970009135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970009136 ATP binding site [chemical binding]; other site 693970009137 Mg2+ binding site [ion binding]; other site 693970009138 G-X-G motif; other site 693970009139 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 693970009140 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 693970009141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970009142 Walker A motif; other site 693970009143 ATP binding site [chemical binding]; other site 693970009144 Walker B motif; other site 693970009145 arginine finger; other site 693970009146 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693970009147 flagellar protein FliS; Validated; Region: fliS; PRK05685 693970009148 flagellar capping protein; Reviewed; Region: fliD; PRK08032 693970009149 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 693970009150 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 693970009151 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 693970009152 FlaG protein; Region: FlaG; pfam03646 693970009153 flagellin; Provisional; Region: PRK12802 693970009154 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693970009155 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693970009156 flagellin; Provisional; Region: PRK12802 693970009157 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693970009158 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693970009159 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 693970009160 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693970009161 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08871 693970009162 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693970009163 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693970009164 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 693970009165 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 693970009166 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 693970009167 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 693970009168 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 693970009169 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 693970009170 Flagellar L-ring protein; Region: FlgH; pfam02107 693970009171 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 693970009172 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693970009173 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693970009174 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 693970009175 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 693970009176 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 693970009177 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 693970009178 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693970009179 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 693970009180 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 693970009181 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 693970009182 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12631 693970009183 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693970009184 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693970009185 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12625 693970009186 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 693970009187 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 693970009188 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 693970009189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970009190 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 693970009191 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693970009192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970009193 active site 693970009194 phosphorylation site [posttranslational modification] 693970009195 intermolecular recognition site; other site 693970009196 dimerization interface [polypeptide binding]; other site 693970009197 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 693970009198 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 693970009199 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 693970009200 FlgN protein; Region: FlgN; pfam05130 693970009201 LPP20 lipoprotein; Region: LPP20; pfam02169 693970009202 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 693970009203 NeuB family; Region: NeuB; pfam03102 693970009204 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 693970009205 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 693970009206 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 693970009207 classical (c) SDRs; Region: SDR_c; cd05233 693970009208 NAD(P) binding site [chemical binding]; other site 693970009209 active site 693970009210 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 693970009211 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 693970009212 TPP-binding site; other site 693970009213 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693970009214 PYR/PP interface [polypeptide binding]; other site 693970009215 dimer interface [polypeptide binding]; other site 693970009216 TPP binding site [chemical binding]; other site 693970009217 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693970009218 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693970009219 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693970009220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970009221 S-adenosylmethionine binding site [chemical binding]; other site 693970009222 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693970009223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970009224 S-adenosylmethionine binding site [chemical binding]; other site 693970009225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 693970009226 N-terminal catalytic domain of alpha-galactosidase; glycoside hydrolase family 57 (GH57); Region: GH57N_PfGalA_like; cd10794 693970009227 putative active site [active] 693970009228 catalytic site [active] 693970009229 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693970009230 active site 693970009231 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 693970009232 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 693970009233 inhibitor-cofactor binding pocket; inhibition site 693970009234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970009235 catalytic residue [active] 693970009236 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 693970009237 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 693970009238 NAD(P) binding site [chemical binding]; other site 693970009239 homodimer interface [polypeptide binding]; other site 693970009240 substrate binding site [chemical binding]; other site 693970009241 active site 693970009242 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 693970009243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 693970009244 binding surface 693970009245 TPR motif; other site 693970009246 Protein of unknown function (DUF2947); Region: DUF2947; pfam11163 693970009247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693970009248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693970009249 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693970009250 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693970009251 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970009252 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693970009253 Protein of unknown function (DUF465); Region: DUF465; pfam04325 693970009254 Cache domain; Region: Cache_1; pfam02743 693970009255 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970009256 dimerization interface [polypeptide binding]; other site 693970009257 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693970009258 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970009259 dimer interface [polypeptide binding]; other site 693970009260 putative CheW interface [polypeptide binding]; other site 693970009261 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 693970009262 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 693970009263 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 693970009264 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 693970009265 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 693970009266 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 693970009267 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 693970009268 dimerization interface [polypeptide binding]; other site 693970009269 ATP binding site [chemical binding]; other site 693970009270 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 693970009271 dimerization interface [polypeptide binding]; other site 693970009272 ATP binding site [chemical binding]; other site 693970009273 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 693970009274 putative active site [active] 693970009275 catalytic triad [active] 693970009276 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 693970009277 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693970009278 substrate binding pocket [chemical binding]; other site 693970009279 membrane-bound complex binding site; other site 693970009280 hinge residues; other site 693970009281 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693970009282 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693970009283 catalytic residue [active] 693970009284 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 693970009285 nucleoside/Zn binding site; other site 693970009286 dimer interface [polypeptide binding]; other site 693970009287 catalytic motif [active] 693970009288 GMP synthase; Reviewed; Region: guaA; PRK00074 693970009289 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 693970009290 AMP/PPi binding site [chemical binding]; other site 693970009291 candidate oxyanion hole; other site 693970009292 catalytic triad [active] 693970009293 potential glutamine specificity residues [chemical binding]; other site 693970009294 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 693970009295 ATP Binding subdomain [chemical binding]; other site 693970009296 Ligand Binding sites [chemical binding]; other site 693970009297 Dimerization subdomain; other site 693970009298 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 693970009299 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 693970009300 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 693970009301 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 693970009302 active site 693970009303 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 693970009304 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 693970009305 generic binding surface II; other site 693970009306 generic binding surface I; other site 693970009307 GTP-binding protein Der; Reviewed; Region: PRK00093 693970009308 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 693970009309 G1 box; other site 693970009310 GTP/Mg2+ binding site [chemical binding]; other site 693970009311 Switch I region; other site 693970009312 G2 box; other site 693970009313 Switch II region; other site 693970009314 G3 box; other site 693970009315 G4 box; other site 693970009316 G5 box; other site 693970009317 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 693970009318 G1 box; other site 693970009319 GTP/Mg2+ binding site [chemical binding]; other site 693970009320 Switch I region; other site 693970009321 G2 box; other site 693970009322 G3 box; other site 693970009323 Switch II region; other site 693970009324 G4 box; other site 693970009325 G5 box; other site 693970009326 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 693970009327 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 693970009328 Trp docking motif [polypeptide binding]; other site 693970009329 active site 693970009330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 693970009331 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 693970009332 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 693970009333 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 693970009334 dimer interface [polypeptide binding]; other site 693970009335 motif 1; other site 693970009336 active site 693970009337 motif 2; other site 693970009338 motif 3; other site 693970009339 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 693970009340 anticodon binding site; other site 693970009341 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 693970009342 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 693970009343 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 693970009344 cytoskeletal protein RodZ; Provisional; Region: PRK10856 693970009345 Helix-turn-helix domain; Region: HTH_25; pfam13413 693970009346 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 693970009347 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 693970009348 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970009349 TPR motif; other site 693970009350 binding surface 693970009351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970009352 binding surface 693970009353 TPR motif; other site 693970009354 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 693970009355 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693970009356 FeS/SAM binding site; other site 693970009357 Domain of unknown function DUF21; Region: DUF21; pfam01595 693970009358 FOG: CBS domain [General function prediction only]; Region: COG0517 693970009359 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693970009360 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 693970009361 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 693970009362 active site 693970009363 metal binding site [ion binding]; metal-binding site 693970009364 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 693970009365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970009366 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 693970009367 The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which regulates expression of the heme uptake receptor HupA; contains the type 2 periplasmic binding fold; Region: PBP2_HupR; cd08431 693970009368 putative dimerization interface [polypeptide binding]; other site 693970009369 DoxX; Region: DoxX; pfam07681 693970009370 Pirin-related protein [General function prediction only]; Region: COG1741 693970009371 Pirin; Region: Pirin; pfam02678 693970009372 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693970009373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970009374 Coenzyme A binding pocket [chemical binding]; other site 693970009375 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693970009376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970009377 Coenzyme A binding pocket [chemical binding]; other site 693970009378 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 693970009379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693970009380 Coenzyme A binding pocket [chemical binding]; other site 693970009381 ParA-like protein; Provisional; Region: PHA02518 693970009382 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693970009383 P-loop; other site 693970009384 Magnesium ion binding site [ion binding]; other site 693970009385 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693970009386 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 693970009387 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970009388 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970009389 metal binding site [ion binding]; metal-binding site 693970009390 active site 693970009391 I-site; other site 693970009392 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 693970009393 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 693970009394 SnoaL-like domain; Region: SnoaL_3; pfam13474 693970009395 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 693970009396 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 693970009397 tetramer interface [polypeptide binding]; other site 693970009398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970009399 catalytic residue [active] 693970009400 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 693970009401 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693970009402 ligand binding site [chemical binding]; other site 693970009403 Conserved TM helix; Region: TM_helix; pfam05552 693970009404 mechanosensitive channel MscS; Provisional; Region: PRK10334 693970009405 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693970009406 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 693970009407 dimer interface [polypeptide binding]; other site 693970009408 catalytic triad [active] 693970009409 peroxidatic and resolving cysteines [active] 693970009410 Predicted membrane protein [Function unknown]; Region: COG2860 693970009411 UPF0126 domain; Region: UPF0126; pfam03458 693970009412 UPF0126 domain; Region: UPF0126; pfam03458 693970009413 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 693970009414 translation initiation factor Sui1; Validated; Region: PRK06824 693970009415 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 693970009416 putative rRNA binding site [nucleotide binding]; other site 693970009417 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 693970009418 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 693970009419 ferrochelatase; Reviewed; Region: hemH; PRK00035 693970009420 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 693970009421 C-terminal domain interface [polypeptide binding]; other site 693970009422 active site 693970009423 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 693970009424 active site 693970009425 N-terminal domain interface [polypeptide binding]; other site 693970009426 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 693970009427 catalytic residues [active] 693970009428 dimer interface [polypeptide binding]; other site 693970009429 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 693970009430 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693970009431 Walker A motif; other site 693970009432 ATP binding site [chemical binding]; other site 693970009433 Walker B motif; other site 693970009434 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 693970009435 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 693970009436 Walker A motif; other site 693970009437 ATP binding site [chemical binding]; other site 693970009438 Walker B motif; other site 693970009439 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 693970009440 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693970009441 catalytic residue [active] 693970009442 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 693970009443 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 693970009444 YGGT family; Region: YGGT; pfam02325 693970009445 YGGT family; Region: YGGT; pfam02325 693970009446 hypothetical protein; Validated; Region: PRK05090 693970009447 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 693970009448 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 693970009449 active site 693970009450 dimerization interface [polypeptide binding]; other site 693970009451 HemN family oxidoreductase; Provisional; Region: PRK05660 693970009452 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693970009453 FeS/SAM binding site; other site 693970009454 HemN C-terminal domain; Region: HemN_C; pfam06969 693970009455 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 693970009456 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 693970009457 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693970009458 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970009459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970009460 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693970009461 putative effector binding pocket; other site 693970009462 dimerization interface [polypeptide binding]; other site 693970009463 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 693970009464 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 693970009465 glutaminase; Provisional; Region: PRK00971 693970009466 hypothetical protein; Provisional; Region: PRK11702 693970009467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970009468 S-adenosylmethionine binding site [chemical binding]; other site 693970009469 adenine DNA glycosylase; Provisional; Region: PRK10880 693970009470 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693970009471 minor groove reading motif; other site 693970009472 helix-hairpin-helix signature motif; other site 693970009473 substrate binding pocket [chemical binding]; other site 693970009474 active site 693970009475 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 693970009476 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 693970009477 DNA binding and oxoG recognition site [nucleotide binding] 693970009478 oxidative damage protection protein; Provisional; Region: PRK05408 693970009479 hypothetical protein; Provisional; Region: PRK03757 693970009480 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 693970009481 Protein of unknown function (DUF3634); Region: DUF3634; pfam12321 693970009482 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 693970009483 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 693970009484 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 693970009485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970009486 S-adenosylmethionine binding site [chemical binding]; other site 693970009487 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 693970009488 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 693970009489 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693970009490 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693970009491 short chain dehydrogenase; Provisional; Region: PRK06101 693970009492 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693970009493 NAD(P) binding site [chemical binding]; other site 693970009494 active site 693970009495 SnoaL-like domain; Region: SnoaL_2; pfam12680 693970009496 DNA photolyase; Region: DNA_photolyase; pfam00875 693970009497 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 693970009498 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693970009499 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 693970009500 DNA binding residues [nucleotide binding] 693970009501 Protein of unknown function (DUF523); Region: DUF523; pfam04463 693970009502 Uncharacterized conserved protein [Function unknown]; Region: COG3272 693970009503 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 693970009504 Adenylosuccinate lyase C-terminus; Region: ADSL_C; cl17237 693970009505 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693970009506 metal-binding site [ion binding] 693970009507 MerT mercuric transport protein; Region: MerT; cl03578 693970009508 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 693970009509 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 693970009510 Transposase; Region: HTH_Tnp_1; cl17663 693970009511 Winged helix-turn helix; Region: HTH_29; pfam13551 693970009512 Homeodomain-like domain; Region: HTH_32; pfam13565 693970009513 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970009514 Integrase core domain; Region: rve; pfam00665 693970009515 Integrase core domain; Region: rve_3; pfam13683 693970009516 Transposase; Region: HTH_Tnp_1; pfam01527 693970009517 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970009518 putative transposase OrfB; Reviewed; Region: PHA02517 693970009519 HTH-like domain; Region: HTH_21; pfam13276 693970009520 Integrase core domain; Region: rve; pfam00665 693970009521 Integrase core domain; Region: rve_2; pfam13333 693970009522 PBP superfamily domain; Region: PBP_like_2; cl17296 693970009523 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693970009524 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 693970009525 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970009526 dimer interface [polypeptide binding]; other site 693970009527 putative CheW interface [polypeptide binding]; other site 693970009528 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 693970009529 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 693970009530 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693970009531 homotrimer interaction site [polypeptide binding]; other site 693970009532 putative active site [active] 693970009533 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 693970009534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 693970009535 YheO-like PAS domain; Region: PAS_6; pfam08348 693970009536 HTH domain; Region: HTH_22; pfam13309 693970009537 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 693970009538 Domain of unknown function (DUF368); Region: DUF368; pfam04018 693970009539 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693970009540 CoenzymeA binding site [chemical binding]; other site 693970009541 subunit interaction site [polypeptide binding]; other site 693970009542 PHB binding site; other site 693970009543 purine nucleoside phosphorylase; Provisional; Region: PRK08202 693970009544 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 693970009545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970009546 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 693970009547 putative dimerization interface [polypeptide binding]; other site 693970009548 putative substrate binding pocket [chemical binding]; other site 693970009549 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 693970009550 nucleoside/Zn binding site; other site 693970009551 dimer interface [polypeptide binding]; other site 693970009552 catalytic motif [active] 693970009553 Predicted membrane protein [Function unknown]; Region: COG2311 693970009554 Protein of unknown function (DUF418); Region: DUF418; cl12135 693970009555 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 693970009556 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 693970009557 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 693970009558 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 693970009559 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693970009560 N-terminal Early set domain associated with the catalytic domain of chitinase; Region: E_set_Chitinase_N; cd02848 693970009561 Glyco_18 domain; Region: Glyco_18; smart00636 693970009562 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 693970009563 active site 693970009564 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 693970009565 aromatic chitin/cellulose binding site residues [chemical binding]; other site 693970009566 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 693970009567 aromatic chitin/cellulose binding site residues [chemical binding]; other site 693970009568 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693970009569 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693970009570 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 693970009571 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 693970009572 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 693970009573 active site 693970009574 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693970009575 Zn2+ binding site [ion binding]; other site 693970009576 Mg2+ binding site [ion binding]; other site 693970009577 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970009578 PAS fold; Region: PAS_3; pfam08447 693970009579 putative active site [active] 693970009580 heme pocket [chemical binding]; other site 693970009581 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693970009582 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970009583 dimer interface [polypeptide binding]; other site 693970009584 putative CheW interface [polypeptide binding]; other site 693970009585 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 693970009586 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693970009587 ATP binding site [chemical binding]; other site 693970009588 Mg++ binding site [ion binding]; other site 693970009589 motif III; other site 693970009590 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970009591 nucleotide binding region [chemical binding]; other site 693970009592 ATP-binding site [chemical binding]; other site 693970009593 putrescine transporter; Provisional; Region: potE; PRK10655 693970009594 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 693970009595 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 693970009596 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 693970009597 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 693970009598 putative catalytic residues [active] 693970009599 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 693970009600 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693970009601 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693970009602 membrane-bound complex binding site; other site 693970009603 hinge residues; other site 693970009604 hypothetical protein; Provisional; Region: PRK09947 693970009605 putative oxidoreductase; Provisional; Region: PRK09849 693970009606 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 693970009607 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 693970009608 hypothetical protein; Provisional; Region: PRK09898 693970009609 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 693970009610 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 693970009611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 693970009612 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 693970009613 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 693970009614 DsrE/DsrF-like family; Region: DrsE; pfam02635 693970009615 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 693970009616 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 693970009617 active site 693970009618 Zn binding site [ion binding]; other site 693970009619 Protein of unknown function, DUF486; Region: DUF486; pfam04342 693970009620 Protein of unknown function (DUF2960); Region: DUF2960; pfam11173 693970009621 RDD family; Region: RDD; pfam06271 693970009622 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 693970009623 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 693970009624 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 693970009625 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 693970009626 multifunctional aminopeptidase A; Provisional; Region: PRK00913 693970009627 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 693970009628 interface (dimer of trimers) [polypeptide binding]; other site 693970009629 Substrate-binding/catalytic site; other site 693970009630 Zn-binding sites [ion binding]; other site 693970009631 PAS domain S-box; Region: sensory_box; TIGR00229 693970009632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970009633 putative active site [active] 693970009634 heme pocket [chemical binding]; other site 693970009635 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970009636 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970009637 metal binding site [ion binding]; metal-binding site 693970009638 active site 693970009639 I-site; other site 693970009640 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 693970009641 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 693970009642 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 693970009643 HIGH motif; other site 693970009644 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 693970009645 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 693970009646 active site 693970009647 KMSKS motif; other site 693970009648 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 693970009649 tRNA binding surface [nucleotide binding]; other site 693970009650 anticodon binding site; other site 693970009651 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 693970009652 carbon storage regulator; Provisional; Region: PRK01712 693970009653 aspartate kinase; Reviewed; Region: PRK06635 693970009654 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 693970009655 putative nucleotide binding site [chemical binding]; other site 693970009656 putative catalytic residues [active] 693970009657 putative Mg ion binding site [ion binding]; other site 693970009658 putative aspartate binding site [chemical binding]; other site 693970009659 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 693970009660 putative allosteric regulatory residue; other site 693970009661 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 693970009662 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 693970009663 motif 1; other site 693970009664 active site 693970009665 motif 2; other site 693970009666 motif 3; other site 693970009667 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 693970009668 DHHA1 domain; Region: DHHA1; pfam02272 693970009669 RecX family; Region: RecX; pfam02631 693970009670 recombinase A; Provisional; Region: recA; PRK09354 693970009671 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 693970009672 hexamer interface [polypeptide binding]; other site 693970009673 Walker A motif; other site 693970009674 ATP binding site [chemical binding]; other site 693970009675 Walker B motif; other site 693970009676 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 693970009677 MutS domain I; Region: MutS_I; pfam01624 693970009678 MutS domain II; Region: MutS_II; pfam05188 693970009679 MutS domain III; Region: MutS_III; pfam05192 693970009680 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 693970009681 Walker A/P-loop; other site 693970009682 ATP binding site [chemical binding]; other site 693970009683 Q-loop/lid; other site 693970009684 ABC transporter signature motif; other site 693970009685 Walker B; other site 693970009686 D-loop; other site 693970009687 H-loop/switch region; other site 693970009688 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 693970009689 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 693970009690 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693970009691 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693970009692 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693970009693 DNA binding residues [nucleotide binding] 693970009694 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 693970009695 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693970009696 Peptidase family M23; Region: Peptidase_M23; pfam01551 693970009697 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 693970009698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970009699 S-adenosylmethionine binding site [chemical binding]; other site 693970009700 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 693970009701 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 693970009702 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 693970009703 Permutation of conserved domain; other site 693970009704 active site 693970009705 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 693970009706 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 693970009707 homotrimer interaction site [polypeptide binding]; other site 693970009708 zinc binding site [ion binding]; other site 693970009709 CDP-binding sites; other site 693970009710 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 693970009711 substrate binding site; other site 693970009712 dimer interface; other site 693970009713 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 693970009714 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 693970009715 enolase; Provisional; Region: eno; PRK00077 693970009716 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 693970009717 dimer interface [polypeptide binding]; other site 693970009718 metal binding site [ion binding]; metal-binding site 693970009719 substrate binding pocket [chemical binding]; other site 693970009720 CTP synthetase; Validated; Region: pyrG; PRK05380 693970009721 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 693970009722 Catalytic site [active] 693970009723 active site 693970009724 UTP binding site [chemical binding]; other site 693970009725 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 693970009726 active site 693970009727 putative oxyanion hole; other site 693970009728 catalytic triad [active] 693970009729 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 693970009730 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 693970009731 homodimer interface [polypeptide binding]; other site 693970009732 metal binding site [ion binding]; metal-binding site 693970009733 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 693970009734 homodimer interface [polypeptide binding]; other site 693970009735 active site 693970009736 putative chemical substrate binding site [chemical binding]; other site 693970009737 metal binding site [ion binding]; metal-binding site 693970009738 agmatine deiminase; Provisional; Region: PRK13551 693970009739 agmatine deiminase; Region: agmatine_aguA; TIGR03380 693970009740 amidase; Validated; Region: PRK06565 693970009741 Amidase; Region: Amidase; cl11426 693970009742 Amidase; Region: Amidase; cl11426 693970009743 methionine synthase; Provisional; Region: PRK01207 693970009744 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 693970009745 substrate binding site [chemical binding]; other site 693970009746 THF binding site; other site 693970009747 zinc-binding site [ion binding]; other site 693970009748 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 693970009749 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 693970009750 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970009751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970009752 Walker A motif; other site 693970009753 ATP binding site [chemical binding]; other site 693970009754 Walker B motif; other site 693970009755 Integrase core domain; Region: rve; pfam00665 693970009756 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 693970009757 HD domain; Region: HD_4; pfam13328 693970009758 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 693970009759 synthetase active site [active] 693970009760 NTP binding site [chemical binding]; other site 693970009761 metal binding site [ion binding]; metal-binding site 693970009762 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 693970009763 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 693970009764 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 693970009765 TRAM domain; Region: TRAM; pfam01938 693970009766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970009767 S-adenosylmethionine binding site [chemical binding]; other site 693970009768 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 693970009769 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 693970009770 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970009771 dimerization interface [polypeptide binding]; other site 693970009772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970009773 dimer interface [polypeptide binding]; other site 693970009774 phosphorylation site [posttranslational modification] 693970009775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970009776 ATP binding site [chemical binding]; other site 693970009777 Mg2+ binding site [ion binding]; other site 693970009778 G-X-G motif; other site 693970009779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970009780 active site 693970009781 phosphorylation site [posttranslational modification] 693970009782 intermolecular recognition site; other site 693970009783 dimerization interface [polypeptide binding]; other site 693970009784 Hpt domain; Region: Hpt; pfam01627 693970009785 Protein of unknown function (DUF416); Region: DUF416; pfam04222 693970009786 Protein of unknown function (DUF3319); Region: DUF3319; pfam11782 693970009787 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970009788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970009789 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693970009790 putative effector binding pocket; other site 693970009791 dimerization interface [polypeptide binding]; other site 693970009792 Membrane transport protein; Region: Mem_trans; cl09117 693970009793 recombination and repair protein; Provisional; Region: PRK10869 693970009794 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 693970009795 Walker A/P-loop; other site 693970009796 ATP binding site [chemical binding]; other site 693970009797 Q-loop/lid; other site 693970009798 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 693970009799 ABC transporter signature motif; other site 693970009800 Walker B; other site 693970009801 D-loop; other site 693970009802 H-loop/switch region; other site 693970009803 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 693970009804 tetramer interfaces [polypeptide binding]; other site 693970009805 binuclear metal-binding site [ion binding]; other site 693970009806 thiamine monophosphate kinase; Provisional; Region: PRK05731 693970009807 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 693970009808 ATP binding site [chemical binding]; other site 693970009809 dimerization interface [polypeptide binding]; other site 693970009810 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 693970009811 putative RNA binding site [nucleotide binding]; other site 693970009812 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 693970009813 homopentamer interface [polypeptide binding]; other site 693970009814 active site 693970009815 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 693970009816 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 693970009817 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 693970009818 dimerization interface [polypeptide binding]; other site 693970009819 active site 693970009820 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 693970009821 Lumazine binding domain; Region: Lum_binding; pfam00677 693970009822 Lumazine binding domain; Region: Lum_binding; pfam00677 693970009823 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 693970009824 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 693970009825 catalytic motif [active] 693970009826 Zn binding site [ion binding]; other site 693970009827 RibD C-terminal domain; Region: RibD_C; cl17279 693970009828 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 693970009829 ATP cone domain; Region: ATP-cone; pfam03477 693970009830 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 693970009831 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 693970009832 dimer interface [polypeptide binding]; other site 693970009833 active site 693970009834 glycine-pyridoxal phosphate binding site [chemical binding]; other site 693970009835 folate binding site [chemical binding]; other site 693970009836 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 693970009837 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693970009838 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693970009839 ABC transporter; Region: ABC_tran_2; pfam12848 693970009840 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693970009841 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970009842 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970009843 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693970009844 putative effector binding pocket; other site 693970009845 dimerization interface [polypeptide binding]; other site 693970009846 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 693970009847 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 693970009848 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 693970009849 catalytic residues [active] 693970009850 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 693970009851 Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425 693970009852 active site 693970009853 metal binding site [ion binding]; metal-binding site 693970009854 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693970009855 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693970009856 substrate binding pocket [chemical binding]; other site 693970009857 membrane-bound complex binding site; other site 693970009858 hinge residues; other site 693970009859 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693970009860 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693970009861 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970009862 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693970009863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970009864 putative substrate translocation pore; other site 693970009865 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693970009866 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693970009867 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693970009868 EamA-like transporter family; Region: EamA; pfam00892 693970009869 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693970009870 EamA-like transporter family; Region: EamA; pfam00892 693970009871 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693970009872 Uncharacterized conserved protein [Function unknown]; Region: COG1432 693970009873 LabA_like proteins; Region: LabA_like/DUF88; cl10034 693970009874 putative metal binding site [ion binding]; other site 693970009875 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 693970009876 apolar tunnel; other site 693970009877 heme binding site [chemical binding]; other site 693970009878 dimerization interface [polypeptide binding]; other site 693970009879 Protein of unknown function (DUF3034); Region: DUF3034; pfam11231 693970009880 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970009881 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970009882 metal binding site [ion binding]; metal-binding site 693970009883 active site 693970009884 I-site; other site 693970009885 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970009886 Cna protein B-type domain; Region: Cna_B; pfam05738 693970009887 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 693970009888 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693970009889 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693970009890 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970009891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693970009892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693970009893 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970009894 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970009895 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693970009896 dimerization interface [polypeptide binding]; other site 693970009897 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970009898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970009899 Walker A motif; other site 693970009900 ATP binding site [chemical binding]; other site 693970009901 Walker B motif; other site 693970009902 Integrase core domain; Region: rve; pfam00665 693970009903 Transposase; Region: HTH_Tnp_1; pfam01527 693970009904 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970009905 putative transposase OrfB; Reviewed; Region: PHA02517 693970009906 HTH-like domain; Region: HTH_21; pfam13276 693970009907 Integrase core domain; Region: rve; pfam00665 693970009908 Integrase core domain; Region: rve_2; pfam13333 693970009909 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693970009910 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 693970009911 substrate binding pocket [chemical binding]; other site 693970009912 membrane-bound complex binding site; other site 693970009913 hinge residues; other site 693970009914 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970009915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970009916 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693970009917 dimerization interface [polypeptide binding]; other site 693970009918 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 693970009919 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 693970009920 GDP-binding site [chemical binding]; other site 693970009921 ACT binding site; other site 693970009922 IMP binding site; other site 693970009923 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 693970009924 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693970009925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970009926 active site 693970009927 phosphorylation site [posttranslational modification] 693970009928 intermolecular recognition site; other site 693970009929 dimerization interface [polypeptide binding]; other site 693970009930 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693970009931 active site 693970009932 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970009933 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970009934 metal binding site [ion binding]; metal-binding site 693970009935 active site 693970009936 I-site; other site 693970009937 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970009938 HDOD domain; Region: HDOD; pfam08668 693970009939 putative protease; Provisional; Region: PRK15452 693970009940 Peptidase family U32; Region: Peptidase_U32; pfam01136 693970009941 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 693970009942 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 693970009943 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 693970009944 calcium binding site 2 [ion binding]; other site 693970009945 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 693970009946 active site 693970009947 catalytic triad [active] 693970009948 calcium binding site 1 [ion binding]; other site 693970009949 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693970009950 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693970009951 SCP-2 sterol transfer family; Region: SCP2; cl01225 693970009952 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 693970009953 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 693970009954 Peptidase family U32; Region: Peptidase_U32; pfam01136 693970009955 putative protease; Provisional; Region: PRK15447 693970009956 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 693970009957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 693970009958 Nucleoside recognition; Region: Gate; pfam07670 693970009959 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 693970009960 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693970009961 putative active site [active] 693970009962 putative metal binding site [ion binding]; other site 693970009963 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 693970009964 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 693970009965 putative acyl-acceptor binding pocket; other site 693970009966 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 693970009967 FOG: CBS domain [General function prediction only]; Region: COG0517 693970009968 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_24; cd04637 693970009969 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 693970009970 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 693970009971 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 693970009972 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 693970009973 chaperone protein TorD; Validated; Region: torD; PRK04976 693970009974 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 693970009975 HAMP domain; Region: HAMP; pfam00672 693970009976 dimerization interface [polypeptide binding]; other site 693970009977 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970009978 dimer interface [polypeptide binding]; other site 693970009979 phosphorylation site [posttranslational modification] 693970009980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970009981 ATP binding site [chemical binding]; other site 693970009982 Mg2+ binding site [ion binding]; other site 693970009983 G-X-G motif; other site 693970009984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970009985 active site 693970009986 phosphorylation site [posttranslational modification] 693970009987 intermolecular recognition site; other site 693970009988 dimerization interface [polypeptide binding]; other site 693970009989 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 693970009990 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 693970009991 putative ligand binding site [chemical binding]; other site 693970009992 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 693970009993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970009994 active site 693970009995 phosphorylation site [posttranslational modification] 693970009996 intermolecular recognition site; other site 693970009997 dimerization interface [polypeptide binding]; other site 693970009998 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693970009999 DNA binding site [nucleotide binding] 693970010000 PilZ domain; Region: PilZ; pfam07238 693970010001 DNA repair protein RadA; Provisional; Region: PRK11823 693970010002 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 693970010003 Walker A motif/ATP binding site; other site 693970010004 ATP binding site [chemical binding]; other site 693970010005 Walker B motif; other site 693970010006 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 693970010007 PilZ domain; Region: PilZ; pfam07238 693970010008 PilZ domain; Region: PilZ; pfam07238 693970010009 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 693970010010 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693970010011 phosphoserine phosphatase SerB; Region: serB; TIGR00338 693970010012 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693970010013 motif II; other site 693970010014 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 693970010015 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 693970010016 phosphopentomutase; Provisional; Region: PRK05362 693970010017 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 693970010018 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 693970010019 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 693970010020 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 693970010021 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 693970010022 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 693970010023 intersubunit interface [polypeptide binding]; other site 693970010024 active site 693970010025 catalytic residue [active] 693970010026 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 693970010027 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 693970010028 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 693970010029 Nucleoside recognition; Region: Gate; pfam07670 693970010030 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 693970010031 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 693970010032 active site 693970010033 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 693970010034 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 693970010035 G1 box; other site 693970010036 putative GEF interaction site [polypeptide binding]; other site 693970010037 GTP/Mg2+ binding site [chemical binding]; other site 693970010038 Switch I region; other site 693970010039 G2 box; other site 693970010040 G3 box; other site 693970010041 Switch II region; other site 693970010042 G4 box; other site 693970010043 G5 box; other site 693970010044 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 693970010045 lipoprotein NlpI; Provisional; Region: PRK11189 693970010046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970010047 binding surface 693970010048 TPR motif; other site 693970010049 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 693970010050 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 693970010051 RNase E interface [polypeptide binding]; other site 693970010052 trimer interface [polypeptide binding]; other site 693970010053 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 693970010054 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 693970010055 RNase E interface [polypeptide binding]; other site 693970010056 trimer interface [polypeptide binding]; other site 693970010057 active site 693970010058 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 693970010059 putative nucleic acid binding region [nucleotide binding]; other site 693970010060 G-X-X-G motif; other site 693970010061 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 693970010062 RNA binding site [nucleotide binding]; other site 693970010063 domain interface; other site 693970010064 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970010065 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970010066 metal binding site [ion binding]; metal-binding site 693970010067 active site 693970010068 I-site; other site 693970010069 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970010070 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 693970010071 16S/18S rRNA binding site [nucleotide binding]; other site 693970010072 S13e-L30e interaction site [polypeptide binding]; other site 693970010073 25S rRNA binding site [nucleotide binding]; other site 693970010074 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 693970010075 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 693970010076 RNA binding site [nucleotide binding]; other site 693970010077 active site 693970010078 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 693970010079 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 693970010080 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 693970010081 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 693970010082 translation initiation factor IF-2; Region: IF-2; TIGR00487 693970010083 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 693970010084 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 693970010085 G1 box; other site 693970010086 putative GEF interaction site [polypeptide binding]; other site 693970010087 GTP/Mg2+ binding site [chemical binding]; other site 693970010088 Switch I region; other site 693970010089 G2 box; other site 693970010090 G3 box; other site 693970010091 Switch II region; other site 693970010092 G4 box; other site 693970010093 G5 box; other site 693970010094 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 693970010095 Translation-initiation factor 2; Region: IF-2; pfam11987 693970010096 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 693970010097 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 693970010098 NusA N-terminal domain; Region: NusA_N; pfam08529 693970010099 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 693970010100 RNA binding site [nucleotide binding]; other site 693970010101 homodimer interface [polypeptide binding]; other site 693970010102 NusA-like KH domain; Region: KH_5; pfam13184 693970010103 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 693970010104 G-X-X-G motif; other site 693970010105 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 693970010106 ribosome maturation protein RimP; Reviewed; Region: PRK00092 693970010107 Sm and related proteins; Region: Sm_like; cl00259 693970010108 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 693970010109 putative oligomer interface [polypeptide binding]; other site 693970010110 putative RNA binding site [nucleotide binding]; other site 693970010111 Preprotein translocase SecG subunit; Region: SecG; pfam03840 693970010112 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 693970010113 triosephosphate isomerase; Provisional; Region: PRK14567 693970010114 substrate binding site [chemical binding]; other site 693970010115 dimer interface [polypeptide binding]; other site 693970010116 catalytic triad [active] 693970010117 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 693970010118 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 693970010119 active site 693970010120 substrate binding site [chemical binding]; other site 693970010121 metal binding site [ion binding]; metal-binding site 693970010122 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 693970010123 dihydropteroate synthase; Region: DHPS; TIGR01496 693970010124 substrate binding pocket [chemical binding]; other site 693970010125 dimer interface [polypeptide binding]; other site 693970010126 inhibitor binding site; inhibition site 693970010127 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 693970010128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970010129 Walker A motif; other site 693970010130 ATP binding site [chemical binding]; other site 693970010131 Walker B motif; other site 693970010132 arginine finger; other site 693970010133 Peptidase family M41; Region: Peptidase_M41; pfam01434 693970010134 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 693970010135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970010136 S-adenosylmethionine binding site [chemical binding]; other site 693970010137 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 693970010138 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13021 693970010139 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 693970010140 Protein export membrane protein; Region: SecD_SecF; pfam02355 693970010141 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK12933 693970010142 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 693970010143 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 693970010144 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 693970010145 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 693970010146 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693970010147 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 693970010148 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 693970010149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 693970010150 GTP-binding protein YchF; Reviewed; Region: PRK09601 693970010151 YchF GTPase; Region: YchF; cd01900 693970010152 G1 box; other site 693970010153 GTP/Mg2+ binding site [chemical binding]; other site 693970010154 Switch I region; other site 693970010155 G2 box; other site 693970010156 Switch II region; other site 693970010157 G3 box; other site 693970010158 G4 box; other site 693970010159 G5 box; other site 693970010160 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 693970010161 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 693970010162 putative active site [active] 693970010163 catalytic residue [active] 693970010164 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK08849 693970010165 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 693970010166 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 693970010167 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 693970010168 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693970010169 FeS/SAM binding site; other site 693970010170 TRAM domain; Region: TRAM; pfam01938 693970010171 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 693970010172 PhoH-like protein; Region: PhoH; pfam02562 693970010173 metal-binding heat shock protein; Provisional; Region: PRK00016 693970010174 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 693970010175 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693970010176 Transporter associated domain; Region: CorC_HlyC; smart01091 693970010177 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 693970010178 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 693970010179 putative active site [active] 693970010180 catalytic triad [active] 693970010181 putative dimer interface [polypeptide binding]; other site 693970010182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970010183 S-adenosylmethionine binding site [chemical binding]; other site 693970010184 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 693970010185 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 693970010186 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 693970010187 HIGH motif; other site 693970010188 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 693970010189 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693970010190 active site 693970010191 KMSKS motif; other site 693970010192 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 693970010193 tRNA binding surface [nucleotide binding]; other site 693970010194 Lipopolysaccharide-assembly; Region: LptE; cl01125 693970010195 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 693970010196 DNA polymerase III, delta subunit; Region: holA; TIGR01128 693970010197 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 693970010198 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 693970010199 active site 693970010200 (T/H)XGH motif; other site 693970010201 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 693970010202 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 693970010203 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 693970010204 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 693970010205 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 693970010206 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 693970010207 Transglycosylase SLT domain; Region: SLT_2; pfam13406 693970010208 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693970010209 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693970010210 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 693970010211 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 693970010212 Sporulation related domain; Region: SPOR; pfam05036 693970010213 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 693970010214 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 693970010215 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 693970010216 hypothetical protein; Provisional; Region: PRK04998 693970010217 lipoate-protein ligase B; Provisional; Region: PRK14342 693970010218 lipoyl synthase; Provisional; Region: PRK05481 693970010219 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693970010220 FeS/SAM binding site; other site 693970010221 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 693970010222 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693970010223 DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436 693970010224 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 693970010225 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 693970010226 dimerization interface [polypeptide binding]; other site 693970010227 DPS ferroxidase diiron center [ion binding]; other site 693970010228 ion pore; other site 693970010229 Predicted membrane protein [Function unknown]; Region: COG3503 693970010230 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 693970010231 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693970010232 N-terminal plug; other site 693970010233 ligand-binding site [chemical binding]; other site 693970010234 SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102 693970010235 SEC-C motif; Region: SEC-C; pfam02810 693970010236 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 693970010237 catalytic site [active] 693970010238 putative active site [active] 693970010239 putative substrate binding site [chemical binding]; other site 693970010240 Protein of unknown function (DUF808); Region: DUF808; pfam05661 693970010241 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 693970010242 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693970010243 active site 693970010244 dimer interface [polypeptide binding]; other site 693970010245 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 693970010246 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 693970010247 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 693970010248 putative RNA binding site [nucleotide binding]; other site 693970010249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970010250 S-adenosylmethionine binding site [chemical binding]; other site 693970010251 Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366 693970010252 Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366 693970010253 hypothetical protein; Provisional; Region: PRK05409 693970010254 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 693970010255 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 693970010256 putative metal binding site [ion binding]; other site 693970010257 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 693970010258 putative catalytic site [active] 693970010259 putative phosphate binding site [ion binding]; other site 693970010260 putative metal binding site [ion binding]; other site 693970010261 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 693970010262 MgtE intracellular N domain; Region: MgtE_N; pfam03448 693970010263 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 693970010264 Divalent cation transporter; Region: MgtE; pfam01769 693970010265 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970010266 dimer interface [polypeptide binding]; other site 693970010267 putative CheW interface [polypeptide binding]; other site 693970010268 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 693970010269 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693970010270 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693970010271 substrate binding pocket [chemical binding]; other site 693970010272 membrane-bound complex binding site; other site 693970010273 hinge residues; other site 693970010274 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693970010275 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693970010276 active site 693970010277 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 693970010278 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693970010279 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 693970010280 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 693970010281 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693970010282 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693970010283 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 693970010284 IMP binding site; other site 693970010285 dimer interface [polypeptide binding]; other site 693970010286 interdomain contacts; other site 693970010287 partial ornithine binding site; other site 693970010288 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 693970010289 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 693970010290 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 693970010291 catalytic site [active] 693970010292 subunit interface [polypeptide binding]; other site 693970010293 dihydrodipicolinate reductase; Provisional; Region: PRK00048 693970010294 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 693970010295 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 693970010296 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 693970010297 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 693970010298 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693970010299 Peptidase family M48; Region: Peptidase_M48; pfam01435 693970010300 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693970010301 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693970010302 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 693970010303 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 693970010304 ATP binding site [chemical binding]; other site 693970010305 putative Mg++ binding site [ion binding]; other site 693970010306 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970010307 nucleotide binding region [chemical binding]; other site 693970010308 ATP-binding site [chemical binding]; other site 693970010309 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970010310 Transposase; Region: HTH_Tnp_1; pfam01527 693970010311 putative transposase OrfB; Reviewed; Region: PHA02517 693970010312 HTH-like domain; Region: HTH_21; pfam13276 693970010313 Integrase core domain; Region: rve; pfam00665 693970010314 Integrase core domain; Region: rve_3; pfam13683 693970010315 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 693970010316 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 693970010317 chaperone protein DnaJ; Provisional; Region: PRK10767 693970010318 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693970010319 HSP70 interaction site [polypeptide binding]; other site 693970010320 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 693970010321 substrate binding site [polypeptide binding]; other site 693970010322 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 693970010323 Zn binding sites [ion binding]; other site 693970010324 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 693970010325 dimer interface [polypeptide binding]; other site 693970010326 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 693970010327 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693970010328 nucleotide binding site [chemical binding]; other site 693970010329 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693970010330 EamA-like transporter family; Region: EamA; pfam00892 693970010331 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 693970010332 putative deacylase active site [active] 693970010333 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 693970010334 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 693970010335 putative catalytic cysteine [active] 693970010336 gamma-glutamyl kinase; Provisional; Region: PRK05429 693970010337 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 693970010338 nucleotide binding site [chemical binding]; other site 693970010339 homotetrameric interface [polypeptide binding]; other site 693970010340 putative phosphate binding site [ion binding]; other site 693970010341 putative allosteric binding site; other site 693970010342 PUA domain; Region: PUA; pfam01472 693970010343 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 693970010344 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; pfam09904 693970010345 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 693970010346 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693970010347 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693970010348 membrane-bound complex binding site; other site 693970010349 hinge residues; other site 693970010350 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693970010351 Ligand Binding Site [chemical binding]; other site 693970010352 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693970010353 Ligand Binding Site [chemical binding]; other site 693970010354 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 693970010355 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 693970010356 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 693970010357 NAD(P) binding site [chemical binding]; other site 693970010358 catalytic residues [active] 693970010359 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693970010360 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693970010361 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 693970010362 Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082 693970010363 Curli assembly protein CsgE; Region: CsgE; pfam10627 693970010364 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 693970010365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970010366 ATP binding site [chemical binding]; other site 693970010367 Mg2+ binding site [ion binding]; other site 693970010368 G-X-G motif; other site 693970010369 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 693970010370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970010371 active site 693970010372 phosphorylation site [posttranslational modification] 693970010373 intermolecular recognition site; other site 693970010374 dimerization interface [polypeptide binding]; other site 693970010375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970010376 Walker A motif; other site 693970010377 ATP binding site [chemical binding]; other site 693970010378 Walker B motif; other site 693970010379 arginine finger; other site 693970010380 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693970010381 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693970010382 FtsX-like permease family; Region: FtsX; pfam02687 693970010383 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693970010384 FtsX-like permease family; Region: FtsX; pfam02687 693970010385 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 693970010386 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693970010387 Walker A/P-loop; other site 693970010388 ATP binding site [chemical binding]; other site 693970010389 Q-loop/lid; other site 693970010390 ABC transporter signature motif; other site 693970010391 Walker B; other site 693970010392 D-loop; other site 693970010393 H-loop/switch region; other site 693970010394 anthranilate synthase; Provisional; Region: PRK13566 693970010395 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693970010396 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693970010397 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970010398 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 693970010399 active site 693970010400 substrate binding pocket [chemical binding]; other site 693970010401 dimer interface [polypeptide binding]; other site 693970010402 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 693970010403 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970010404 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970010405 Integrase core domain; Region: rve; pfam00665 693970010406 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693970010407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970010408 Coenzyme A binding pocket [chemical binding]; other site 693970010409 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693970010410 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693970010411 DNA-binding site [nucleotide binding]; DNA binding site 693970010412 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693970010413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970010414 homodimer interface [polypeptide binding]; other site 693970010415 catalytic residue [active] 693970010416 MAPEG family; Region: MAPEG; cl09190 693970010417 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970010418 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693970010419 Coenzyme A binding pocket [chemical binding]; other site 693970010420 AAA domain; Region: AAA_33; pfam13671 693970010421 AAA domain; Region: AAA_17; pfam13207 693970010422 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 693970010423 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 693970010424 dimer interface [polypeptide binding]; other site 693970010425 active site 693970010426 metal binding site [ion binding]; metal-binding site 693970010427 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693970010428 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 693970010429 NAD(P) binding site [chemical binding]; other site 693970010430 catalytic residues [active] 693970010431 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 693970010432 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 693970010433 cobalamin binding residues [chemical binding]; other site 693970010434 putative BtuC binding residues; other site 693970010435 dimer interface [polypeptide binding]; other site 693970010436 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 693970010437 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 693970010438 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 693970010439 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 693970010440 homodimer interface [polypeptide binding]; other site 693970010441 Walker A motif; other site 693970010442 ATP binding site [chemical binding]; other site 693970010443 hydroxycobalamin binding site [chemical binding]; other site 693970010444 Walker B motif; other site 693970010445 cobyric acid synthase; Provisional; Region: PRK00784 693970010446 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 693970010447 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 693970010448 catalytic triad [active] 693970010449 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 693970010450 homotrimer interface [polypeptide binding]; other site 693970010451 Walker A motif; other site 693970010452 GTP binding site [chemical binding]; other site 693970010453 Walker B motif; other site 693970010454 cobalamin synthase; Reviewed; Region: cobS; PRK00235 693970010455 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 693970010456 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 693970010457 putative dimer interface [polypeptide binding]; other site 693970010458 active site pocket [active] 693970010459 putative cataytic base [active] 693970010460 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 693970010461 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693970010462 ABC-ATPase subunit interface; other site 693970010463 dimer interface [polypeptide binding]; other site 693970010464 putative PBP binding regions; other site 693970010465 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 693970010466 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693970010467 Walker A/P-loop; other site 693970010468 ATP binding site [chemical binding]; other site 693970010469 Q-loop/lid; other site 693970010470 ABC transporter signature motif; other site 693970010471 Walker B; other site 693970010472 D-loop; other site 693970010473 H-loop/switch region; other site 693970010474 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693970010475 catalytic core [active] 693970010476 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 693970010477 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 693970010478 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 693970010479 substrate binding pocket [chemical binding]; other site 693970010480 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 693970010481 B12 binding site [chemical binding]; other site 693970010482 cobalt ligand [ion binding]; other site 693970010483 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 693970010484 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970010485 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970010486 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693970010487 putative effector binding pocket; other site 693970010488 dimerization interface [polypeptide binding]; other site 693970010489 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 693970010490 classical (c) SDRs; Region: SDR_c; cd05233 693970010491 NAD(P) binding site [chemical binding]; other site 693970010492 active site 693970010493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970010494 PAS domain; Region: PAS_9; pfam13426 693970010495 putative active site [active] 693970010496 heme pocket [chemical binding]; other site 693970010497 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970010498 PAS domain; Region: PAS_9; pfam13426 693970010499 putative active site [active] 693970010500 heme pocket [chemical binding]; other site 693970010501 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970010502 dimer interface [polypeptide binding]; other site 693970010503 putative CheW interface [polypeptide binding]; other site 693970010504 Uncharacterized conserved protein [Function unknown]; Region: COG1479 693970010505 Protein of unknown function DUF262; Region: DUF262; pfam03235 693970010506 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693970010507 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693970010508 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693970010509 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693970010510 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 693970010511 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 693970010512 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693970010513 Cytochrome c; Region: Cytochrom_C; pfam00034 693970010514 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693970010515 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693970010516 Cytochrome c; Region: Cytochrom_C; pfam00034 693970010517 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970010518 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693970010519 putative active site [active] 693970010520 heme pocket [chemical binding]; other site 693970010521 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970010522 putative active site [active] 693970010523 heme pocket [chemical binding]; other site 693970010524 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970010525 dimer interface [polypeptide binding]; other site 693970010526 putative CheW interface [polypeptide binding]; other site 693970010527 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 693970010528 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693970010529 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970010530 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970010531 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693970010532 putative effector binding pocket; other site 693970010533 dimerization interface [polypeptide binding]; other site 693970010534 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 693970010535 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 693970010536 Nucleoside recognition; Region: Gate; pfam07670 693970010537 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 693970010538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693970010539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693970010540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693970010541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693970010542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693970010543 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 693970010544 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 693970010545 Rhomboid family; Region: Rhomboid; pfam01694 693970010546 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 693970010547 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 693970010548 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693970010549 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693970010550 LrgB-like family; Region: LrgB; pfam04172 693970010551 LrgA family; Region: LrgA; cl00608 693970010552 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970010553 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970010554 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 693970010555 putative dimerization interface [polypeptide binding]; other site 693970010556 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693970010557 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693970010558 substrate binding pocket [chemical binding]; other site 693970010559 membrane-bound complex binding site; other site 693970010560 hinge residues; other site 693970010561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693970010562 dimer interface [polypeptide binding]; other site 693970010563 conserved gate region; other site 693970010564 putative PBP binding loops; other site 693970010565 ABC-ATPase subunit interface; other site 693970010566 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693970010567 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693970010568 Walker A/P-loop; other site 693970010569 ATP binding site [chemical binding]; other site 693970010570 Q-loop/lid; other site 693970010571 ABC transporter signature motif; other site 693970010572 Walker B; other site 693970010573 D-loop; other site 693970010574 H-loop/switch region; other site 693970010575 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 693970010576 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 693970010577 FMN binding site [chemical binding]; other site 693970010578 dimer interface [polypeptide binding]; other site 693970010579 DNA-J related protein; Region: DNAJ_related; pfam12339 693970010580 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693970010581 HSP70 interaction site [polypeptide binding]; other site 693970010582 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 693970010583 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 693970010584 catalytic residues [active] 693970010585 hinge region; other site 693970010586 alpha helical domain; other site 693970010587 GlyGly-CTERM domain; Region: GlyGly_CTERM; TIGR03501 693970010588 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 693970010589 Flavodoxin domain; Region: Flavodoxin_5; cl17428 693970010590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970010591 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693970010592 putative substrate translocation pore; other site 693970010593 TIGR03899 family protein; Region: TIGR03899 693970010594 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693970010595 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 693970010596 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970010597 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970010598 metal binding site [ion binding]; metal-binding site 693970010599 active site 693970010600 I-site; other site 693970010601 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970010602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693970010603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970010604 ATP binding site [chemical binding]; other site 693970010605 Mg2+ binding site [ion binding]; other site 693970010606 G-X-G motif; other site 693970010607 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 693970010608 ligand-binding site [chemical binding]; other site 693970010609 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 693970010610 TrkA-C domain; Region: TrkA_C; pfam02080 693970010611 TrkA-C domain; Region: TrkA_C; pfam02080 693970010612 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 693970010613 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 693970010614 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 693970010615 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 693970010616 CysD dimerization site [polypeptide binding]; other site 693970010617 G1 box; other site 693970010618 putative GEF interaction site [polypeptide binding]; other site 693970010619 GTP/Mg2+ binding site [chemical binding]; other site 693970010620 Switch I region; other site 693970010621 G2 box; other site 693970010622 G3 box; other site 693970010623 Switch II region; other site 693970010624 G4 box; other site 693970010625 G5 box; other site 693970010626 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 693970010627 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 693970010628 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 693970010629 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 693970010630 Active Sites [active] 693970010631 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 693970010632 active site 693970010633 SAM binding site [chemical binding]; other site 693970010634 homodimer interface [polypeptide binding]; other site 693970010635 Phage endonuclease I; Region: Phage_endo_I; cl11622 693970010636 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 693970010637 dimerization interface [polypeptide binding]; other site 693970010638 substrate binding site [chemical binding]; other site 693970010639 active site 693970010640 calcium binding site [ion binding]; other site 693970010641 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 693970010642 Active site serine [active] 693970010643 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 693970010644 Transglycosylase; Region: Transgly; cl17702 693970010645 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 693970010646 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 693970010647 Active Sites [active] 693970010648 sulfite reductase subunit beta; Provisional; Region: PRK13504 693970010649 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 693970010650 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 693970010651 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 693970010652 Flavodoxin; Region: Flavodoxin_1; pfam00258 693970010653 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 693970010654 FAD binding pocket [chemical binding]; other site 693970010655 FAD binding motif [chemical binding]; other site 693970010656 catalytic residues [active] 693970010657 NAD binding pocket [chemical binding]; other site 693970010658 phosphate binding motif [ion binding]; other site 693970010659 beta-alpha-beta structure motif; other site 693970010660 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 693970010661 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 693970010662 ligand binding site [chemical binding]; other site 693970010663 homodimer interface [polypeptide binding]; other site 693970010664 NAD(P) binding site [chemical binding]; other site 693970010665 trimer interface B [polypeptide binding]; other site 693970010666 trimer interface A [polypeptide binding]; other site 693970010667 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 693970010668 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 693970010669 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 693970010670 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693970010671 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 693970010672 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 693970010673 putative ribose interaction site [chemical binding]; other site 693970010674 putative ADP binding site [chemical binding]; other site 693970010675 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 693970010676 active site 693970010677 HIGH motif; other site 693970010678 nucleotide binding site [chemical binding]; other site 693970010679 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 693970010680 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 693970010681 putative acyl-acceptor binding pocket; other site 693970010682 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 693970010683 potassium/proton antiporter; Reviewed; Region: PRK05326 693970010684 TrkA-C domain; Region: TrkA_C; pfam02080 693970010685 Transporter associated domain; Region: CorC_HlyC; smart01091 693970010686 L,D-transpeptidase; Provisional; Region: PRK10260 693970010687 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693970010688 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693970010689 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 693970010690 putative active site [active] 693970010691 Zn binding site [ion binding]; other site 693970010692 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693970010693 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693970010694 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693970010695 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693970010696 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 693970010697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970010698 active site 693970010699 phosphorylation site [posttranslational modification] 693970010700 intermolecular recognition site; other site 693970010701 dimerization interface [polypeptide binding]; other site 693970010702 Transcriptional regulator; Region: CitT; pfam12431 693970010703 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 693970010704 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 693970010705 PAS domain; Region: PAS; smart00091 693970010706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970010707 ATP binding site [chemical binding]; other site 693970010708 Mg2+ binding site [ion binding]; other site 693970010709 G-X-G motif; other site 693970010710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 693970010711 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 693970010712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 693970010713 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 693970010714 Predicted ATPase [General function prediction only]; Region: COG1485 693970010715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970010716 Walker A/P-loop; other site 693970010717 ATP binding site [chemical binding]; other site 693970010718 ABC transporter signature motif; other site 693970010719 Walker B; other site 693970010720 D-loop; other site 693970010721 H-loop/switch region; other site 693970010722 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970010723 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970010724 Integrase core domain; Region: rve; pfam00665 693970010725 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 693970010726 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693970010727 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970010728 dimerization interface [polypeptide binding]; other site 693970010729 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970010730 dimer interface [polypeptide binding]; other site 693970010731 putative CheW interface [polypeptide binding]; other site 693970010732 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970010733 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970010734 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693970010735 dimerization interface [polypeptide binding]; other site 693970010736 Domain of unknown function (DUF897); Region: DUF897; pfam05982 693970010737 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693970010738 GAF domain; Region: GAF; pfam01590 693970010739 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970010740 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970010741 metal binding site [ion binding]; metal-binding site 693970010742 active site 693970010743 I-site; other site 693970010744 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 693970010745 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 693970010746 metal binding triad; other site 693970010747 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 693970010748 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 693970010749 metal binding triad; other site 693970010750 spermidine synthase; Provisional; Region: PRK03612 693970010751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693970010752 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938 693970010753 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 693970010754 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 693970010755 Ion channel; Region: Ion_trans_2; pfam07885 693970010756 Uncharacterized conserved protein [Function unknown]; Region: COG3025 693970010757 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 693970010758 putative active site [active] 693970010759 putative metal binding residues [ion binding]; other site 693970010760 signature motif; other site 693970010761 putative triphosphate binding site [ion binding]; other site 693970010762 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 693970010763 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 693970010764 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 693970010765 Bacterial SH3 domain homologues; Region: SH3b; smart00287 693970010766 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 693970010767 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 693970010768 Proline dehydrogenase; Region: Pro_dh; pfam01619 693970010769 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 693970010770 Glutamate binding site [chemical binding]; other site 693970010771 NAD binding site [chemical binding]; other site 693970010772 catalytic residues [active] 693970010773 Protein of unknown function, DUF599; Region: DUF599; pfam04654 693970010774 Helix-turn-helix domain; Region: HTH_17; pfam12728 693970010775 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 693970010776 putative active site [active] 693970010777 putative metal binding residues [ion binding]; other site 693970010778 signature motif; other site 693970010779 putative triphosphate binding site [ion binding]; other site 693970010780 dimer interface [polypeptide binding]; other site 693970010781 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 693970010782 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693970010783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970010784 Walker A/P-loop; other site 693970010785 ATP binding site [chemical binding]; other site 693970010786 Q-loop/lid; other site 693970010787 ABC transporter signature motif; other site 693970010788 Walker B; other site 693970010789 D-loop; other site 693970010790 H-loop/switch region; other site 693970010791 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 693970010792 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693970010793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970010794 Walker A/P-loop; other site 693970010795 ATP binding site [chemical binding]; other site 693970010796 Q-loop/lid; other site 693970010797 ABC transporter signature motif; other site 693970010798 Walker B; other site 693970010799 D-loop; other site 693970010800 H-loop/switch region; other site 693970010801 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 693970010802 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 693970010803 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693970010804 ATP binding site [chemical binding]; other site 693970010805 Mg++ binding site [ion binding]; other site 693970010806 motif III; other site 693970010807 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970010808 nucleotide binding region [chemical binding]; other site 693970010809 ATP-binding site [chemical binding]; other site 693970010810 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 693970010811 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693970010812 ATP binding site [chemical binding]; other site 693970010813 Mg++ binding site [ion binding]; other site 693970010814 motif III; other site 693970010815 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970010816 nucleotide binding region [chemical binding]; other site 693970010817 ATP-binding site [chemical binding]; other site 693970010818 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 693970010819 putative RNA binding site [nucleotide binding]; other site 693970010820 Pirin-related protein [General function prediction only]; Region: COG1741 693970010821 Pirin; Region: Pirin; pfam02678 693970010822 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 693970010823 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693970010824 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693970010825 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 693970010826 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 693970010827 DNA binding site [nucleotide binding] 693970010828 active site 693970010829 short chain dehydrogenase; Provisional; Region: PRK07478 693970010830 classical (c) SDRs; Region: SDR_c; cd05233 693970010831 NAD(P) binding site [chemical binding]; other site 693970010832 active site 693970010833 SnoaL-like domain; Region: SnoaL_2; pfam12680 693970010834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693970010835 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 693970010836 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 693970010837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970010838 Walker A/P-loop; other site 693970010839 ATP binding site [chemical binding]; other site 693970010840 Q-loop/lid; other site 693970010841 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693970010842 ABC transporter; Region: ABC_tran_2; pfam12848 693970010843 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693970010844 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 693970010845 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693970010846 Predicted transcriptional regulators [Transcription]; Region: COG1733 693970010847 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 693970010848 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 693970010849 classical (c) SDRs; Region: SDR_c; cd05233 693970010850 NAD(P) binding site [chemical binding]; other site 693970010851 active site 693970010852 Transcriptional activator [Transcription]; Region: ChrR; COG3806 693970010853 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 693970010854 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 693970010855 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 693970010856 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 693970010857 putative hydrolase; Provisional; Region: PRK10985 693970010858 Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180 693970010859 phosphoribulokinase; Provisional; Region: PRK15453 693970010860 active site 693970010861 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693970010862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970010863 Coenzyme A binding pocket [chemical binding]; other site 693970010864 aminopeptidase B; Provisional; Region: PRK05015 693970010865 Peptidase; Region: DUF3663; pfam12404 693970010866 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 693970010867 interface (dimer of trimers) [polypeptide binding]; other site 693970010868 Substrate-binding/catalytic site; other site 693970010869 Zn-binding sites [ion binding]; other site 693970010870 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 693970010871 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 693970010872 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 693970010873 active site 693970010874 nucleotide binding site [chemical binding]; other site 693970010875 HIGH motif; other site 693970010876 KMSKS motif; other site 693970010877 poly(A) polymerase; Region: pcnB; TIGR01942 693970010878 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 693970010879 active site 693970010880 NTP binding site [chemical binding]; other site 693970010881 metal binding triad [ion binding]; metal-binding site 693970010882 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 693970010883 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 693970010884 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 693970010885 catalytic center binding site [active] 693970010886 ATP binding site [chemical binding]; other site 693970010887 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 693970010888 oligomerization interface [polypeptide binding]; other site 693970010889 active site 693970010890 metal binding site [ion binding]; metal-binding site 693970010891 Pantoate-beta-alanine ligase; Region: PanC; cd00560 693970010892 pantoate--beta-alanine ligase; Region: panC; TIGR00018 693970010893 active site 693970010894 ATP-binding site [chemical binding]; other site 693970010895 pantoate-binding site; other site 693970010896 HXXH motif; other site 693970010897 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 693970010898 Curlin associated repeat; Region: Curlin_rpt; pfam07012 693970010899 Curlin associated repeat; Region: Curlin_rpt; pfam07012 693970010900 major curlin subunit; Provisional; Region: csgA; PRK10051 693970010901 Curlin associated repeat; Region: Curlin_rpt; pfam07012 693970010902 Curlin associated repeat; Region: Curlin_rpt; pfam07012 693970010903 Curlin associated repeat; Region: Curlin_rpt; pfam07012 693970010904 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693970010905 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693970010906 DNA binding residues [nucleotide binding] 693970010907 dimerization interface [polypeptide binding]; other site 693970010908 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 693970010909 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 693970010910 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 693970010911 ligand binding site [chemical binding]; other site 693970010912 NAD binding site [chemical binding]; other site 693970010913 tetramer interface [polypeptide binding]; other site 693970010914 catalytic site [active] 693970010915 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 693970010916 L-serine binding site [chemical binding]; other site 693970010917 ACT domain interface; other site 693970010918 putative global regulator; Reviewed; Region: PRK09559 693970010919 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 693970010920 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 693970010921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970010922 active site 693970010923 phosphorylation site [posttranslational modification] 693970010924 intermolecular recognition site; other site 693970010925 dimerization interface [polypeptide binding]; other site 693970010926 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693970010927 Zn2+ binding site [ion binding]; other site 693970010928 Mg2+ binding site [ion binding]; other site 693970010929 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 693970010930 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693970010931 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970010932 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693970010933 putative active site [active] 693970010934 heme pocket [chemical binding]; other site 693970010935 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693970010936 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970010937 putative active site [active] 693970010938 heme pocket [chemical binding]; other site 693970010939 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693970010940 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970010941 putative active site [active] 693970010942 heme pocket [chemical binding]; other site 693970010943 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970010944 putative active site [active] 693970010945 heme pocket [chemical binding]; other site 693970010946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970010947 dimer interface [polypeptide binding]; other site 693970010948 phosphorylation site [posttranslational modification] 693970010949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970010950 ATP binding site [chemical binding]; other site 693970010951 Mg2+ binding site [ion binding]; other site 693970010952 G-X-G motif; other site 693970010953 Response regulator receiver domain; Region: Response_reg; pfam00072 693970010954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970010955 active site 693970010956 phosphorylation site [posttranslational modification] 693970010957 intermolecular recognition site; other site 693970010958 dimerization interface [polypeptide binding]; other site 693970010959 Response regulator receiver domain; Region: Response_reg; pfam00072 693970010960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970010961 active site 693970010962 phosphorylation site [posttranslational modification] 693970010963 intermolecular recognition site; other site 693970010964 dimerization interface [polypeptide binding]; other site 693970010965 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 693970010966 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693970010967 amino acid carrier protein; Region: agcS; TIGR00835 693970010968 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 693970010969 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693970010970 Walker A/P-loop; other site 693970010971 ATP binding site [chemical binding]; other site 693970010972 Q-loop/lid; other site 693970010973 ABC transporter signature motif; other site 693970010974 Walker B; other site 693970010975 D-loop; other site 693970010976 H-loop/switch region; other site 693970010977 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 693970010978 FtsX-like permease family; Region: FtsX; pfam02687 693970010979 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 693970010980 NapD protein; Region: NapD; pfam03927 693970010981 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 693970010982 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 693970010983 [4Fe-4S] binding site [ion binding]; other site 693970010984 molybdopterin cofactor binding site; other site 693970010985 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 693970010986 molybdopterin cofactor binding site; other site 693970010987 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 693970010988 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970010989 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970010990 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 693970010991 putative dimerization interface [polypeptide binding]; other site 693970010992 elongation factor G; Reviewed; Region: PRK00007 693970010993 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 693970010994 G1 box; other site 693970010995 putative GEF interaction site [polypeptide binding]; other site 693970010996 GTP/Mg2+ binding site [chemical binding]; other site 693970010997 Switch I region; other site 693970010998 G2 box; other site 693970010999 G3 box; other site 693970011000 Switch II region; other site 693970011001 G4 box; other site 693970011002 G5 box; other site 693970011003 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 693970011004 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 693970011005 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 693970011006 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970011007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970011008 Walker A motif; other site 693970011009 ATP binding site [chemical binding]; other site 693970011010 Walker B motif; other site 693970011011 Integrase core domain; Region: rve; pfam00665 693970011012 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 693970011013 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 693970011014 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693970011015 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693970011016 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 693970011017 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693970011018 carboxyltransferase (CT) interaction site; other site 693970011019 biotinylation site [posttranslational modification]; other site 693970011020 LysR family transcriptional regulator; Provisional; Region: PRK14997 693970011021 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970011022 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 693970011023 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693970011024 putative effector binding pocket; other site 693970011025 dimerization interface [polypeptide binding]; other site 693970011026 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 693970011027 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 693970011028 putative substrate binding pocket [chemical binding]; other site 693970011029 AC domain interface; other site 693970011030 catalytic triad [active] 693970011031 AB domain interface; other site 693970011032 hypothetical protein; Provisional; Region: PRK04860 693970011033 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 693970011034 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 693970011035 RNA methyltransferase, RsmE family; Region: TIGR00046 693970011036 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 693970011037 glutathione synthetase; Provisional; Region: PRK05246 693970011038 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 693970011039 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 693970011040 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 693970011041 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693970011042 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 693970011043 dimer interface [polypeptide binding]; other site 693970011044 Alkaline phosphatase homologues; Region: alkPPc; smart00098 693970011045 active site 693970011046 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 693970011047 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 693970011048 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 693970011049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970011050 S-adenosylmethionine binding site [chemical binding]; other site 693970011051 Protein of unknown function (DUF342); Region: DUF342; pfam03961 693970011052 protein structure with unknown function; Region: DUF4144; pfam13642 693970011053 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 693970011054 Peptidase family M50; Region: Peptidase_M50; pfam02163 693970011055 active site 693970011056 putative substrate binding region [chemical binding]; other site 693970011057 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 693970011058 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 693970011059 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693970011060 Walker A/P-loop; other site 693970011061 ATP binding site [chemical binding]; other site 693970011062 Q-loop/lid; other site 693970011063 ABC transporter signature motif; other site 693970011064 Walker B; other site 693970011065 D-loop; other site 693970011066 H-loop/switch region; other site 693970011067 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693970011068 FtsX-like permease family; Region: FtsX; pfam02687 693970011069 macrolide transporter subunit MacA; Provisional; Region: PRK11578 693970011070 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693970011071 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970011072 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 693970011073 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 693970011074 TOBE domain; Region: TOBE; cl01440 693970011075 TOBE domain; Region: TOBE; cl01440 693970011076 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 693970011077 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693970011078 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 693970011079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693970011080 dimer interface [polypeptide binding]; other site 693970011081 conserved gate region; other site 693970011082 putative PBP binding loops; other site 693970011083 ABC-ATPase subunit interface; other site 693970011084 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 693970011085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970011086 Walker A/P-loop; other site 693970011087 ATP binding site [chemical binding]; other site 693970011088 Q-loop/lid; other site 693970011089 ABC transporter signature motif; other site 693970011090 Walker B; other site 693970011091 D-loop; other site 693970011092 H-loop/switch region; other site 693970011093 TOBE domain; Region: TOBE; cl01440 693970011094 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693970011095 active site 693970011096 catalytic residues [active] 693970011097 DNA binding site [nucleotide binding] 693970011098 Int/Topo IB signature motif; other site 693970011099 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970011100 non-specific DNA binding site [nucleotide binding]; other site 693970011101 salt bridge; other site 693970011102 sequence-specific DNA binding site [nucleotide binding]; other site 693970011103 Transposase; Region: HTH_Tnp_1; cl17663 693970011104 Integrase core domain; Region: rve; pfam00665 693970011105 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970011106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970011107 Walker A motif; other site 693970011108 ATP binding site [chemical binding]; other site 693970011109 Walker B motif; other site 693970011110 Transposase; Region: HTH_Tnp_1; pfam01527 693970011111 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970011112 putative transposase OrfB; Reviewed; Region: PHA02517 693970011113 HTH-like domain; Region: HTH_21; pfam13276 693970011114 Integrase core domain; Region: rve; pfam00665 693970011115 Integrase core domain; Region: rve_2; pfam13333 693970011116 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 693970011117 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 693970011118 active site 693970011119 DNA binding site [nucleotide binding] 693970011120 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 693970011121 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693970011122 Catalytic site [active] 693970011123 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970011124 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970011125 Integrase core domain; Region: rve; pfam00665 693970011126 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693970011127 active site 693970011128 catalytic residues [active] 693970011129 DNA binding site [nucleotide binding] 693970011130 Int/Topo IB signature motif; other site 693970011131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970011132 Walker A motif; other site 693970011133 ATP binding site [chemical binding]; other site 693970011134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970011135 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 693970011136 Walker A motif; other site 693970011137 ATP binding site [chemical binding]; other site 693970011138 Walker B motif; other site 693970011139 arginine finger; other site 693970011140 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 693970011141 MPN+ (JAMM) motif; other site 693970011142 Zinc-binding site [ion binding]; other site 693970011143 Protein of unknown function (DUF2787); Region: DUF2787; pfam10980 693970011144 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 693970011145 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 693970011146 HAMP domain; Region: HAMP; pfam00672 693970011147 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693970011148 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970011149 dimer interface [polypeptide binding]; other site 693970011150 putative CheW interface [polypeptide binding]; other site 693970011151 Hemerythrin; Region: Hemerythrin; cd12107 693970011152 Fe binding site [ion binding]; other site 693970011153 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 693970011154 Superinfection exclusion protein B; Region: SieB; pfam14163 693970011155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 693970011156 dimer interface [polypeptide binding]; other site 693970011157 phosphorylation site [posttranslational modification] 693970011158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970011159 ATP binding site [chemical binding]; other site 693970011160 Mg2+ binding site [ion binding]; other site 693970011161 G-X-G motif; other site 693970011162 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 693970011163 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 693970011164 putative ATP binding site [chemical binding]; other site 693970011165 putative substrate interface [chemical binding]; other site 693970011166 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693970011167 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693970011168 eyelet of channel; other site 693970011169 trimer interface [polypeptide binding]; other site 693970011170 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693970011171 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693970011172 eyelet of channel; other site 693970011173 trimer interface [polypeptide binding]; other site 693970011174 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 693970011175 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 693970011176 CAP-like domain; other site 693970011177 active site 693970011178 primary dimer interface [polypeptide binding]; other site 693970011179 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 693970011180 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 693970011181 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 693970011182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970011183 ATP binding site [chemical binding]; other site 693970011184 Mg2+ binding site [ion binding]; other site 693970011185 G-X-G motif; other site 693970011186 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 693970011187 anchoring element; other site 693970011188 dimer interface [polypeptide binding]; other site 693970011189 ATP binding site [chemical binding]; other site 693970011190 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 693970011191 active site 693970011192 metal binding site [ion binding]; metal-binding site 693970011193 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 693970011194 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 693970011195 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693970011196 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 693970011197 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693970011198 active site 693970011199 metal binding site [ion binding]; metal-binding site 693970011200 hexamer interface [polypeptide binding]; other site 693970011201 Protein of unknown function (DUF1249); Region: DUF1249; pfam06853 693970011202 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 693970011203 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 693970011204 dimer interface [polypeptide binding]; other site 693970011205 ADP-ribose binding site [chemical binding]; other site 693970011206 active site 693970011207 nudix motif; other site 693970011208 metal binding site [ion binding]; metal-binding site 693970011209 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 693970011210 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 693970011211 Protein of unknown function (DUF461); Region: DUF461; pfam04314 693970011212 enoyl-CoA hydratase; Provisional; Region: PRK06688 693970011213 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693970011214 substrate binding site [chemical binding]; other site 693970011215 oxyanion hole (OAH) forming residues; other site 693970011216 trimer interface [polypeptide binding]; other site 693970011217 PspC domain; Region: PspC; pfam04024 693970011218 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 693970011219 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 693970011220 FMN binding site [chemical binding]; other site 693970011221 active site 693970011222 catalytic residues [active] 693970011223 substrate binding site [chemical binding]; other site 693970011224 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 693970011225 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693970011226 active site 693970011227 DNA binding site [nucleotide binding] 693970011228 Int/Topo IB signature motif; other site 693970011229 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 693970011230 Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956 693970011231 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 693970011232 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 693970011233 oligomer interface [polypeptide binding]; other site 693970011234 active site residues [active] 693970011235 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 693970011236 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 693970011237 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 693970011238 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 693970011239 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 693970011240 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 693970011241 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 693970011242 catalytic site [active] 693970011243 putative active site [active] 693970011244 putative substrate binding site [chemical binding]; other site 693970011245 dimer interface [polypeptide binding]; other site 693970011246 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970011247 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693970011248 non-specific DNA binding site [nucleotide binding]; other site 693970011249 salt bridge; other site 693970011250 sequence-specific DNA binding site [nucleotide binding]; other site 693970011251 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693970011252 active site 693970011253 DNA binding site [nucleotide binding] 693970011254 Int/Topo IB signature motif; other site 693970011255 Replication protein P; Region: Phage_lambda_P; pfam06992 693970011256 Helix-turn-helix domain; Region: HTH_36; pfam13730 693970011257 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693970011258 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 693970011259 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970011260 non-specific DNA binding site [nucleotide binding]; other site 693970011261 salt bridge; other site 693970011262 sequence-specific DNA binding site [nucleotide binding]; other site 693970011263 Predicted transcriptional regulator [Transcription]; Region: COG2932 693970011264 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693970011265 Catalytic site [active] 693970011266 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970011267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970011268 Walker A motif; other site 693970011269 ATP binding site [chemical binding]; other site 693970011270 Walker B motif; other site 693970011271 Integrase core domain; Region: rve; pfam00665 693970011272 Transposase; Region: HTH_Tnp_1; pfam01527 693970011273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970011274 putative transposase OrfB; Reviewed; Region: PHA02517 693970011275 HTH-like domain; Region: HTH_21; pfam13276 693970011276 Integrase core domain; Region: rve; pfam00665 693970011277 Integrase core domain; Region: rve_2; pfam13333 693970011278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970011279 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 693970011280 Walker A motif; other site 693970011281 ATP binding site [chemical binding]; other site 693970011282 Walker B motif; other site 693970011283 arginine finger; other site 693970011284 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 693970011285 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 693970011286 Transposase; Region: HTH_Tnp_1; cl17663 693970011287 Winged helix-turn helix; Region: HTH_29; pfam13551 693970011288 Homeodomain-like domain; Region: HTH_32; pfam13565 693970011289 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970011290 Integrase core domain; Region: rve; pfam00665 693970011291 Integrase core domain; Region: rve_3; pfam13683 693970011292 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693970011293 Coenzyme A binding pocket [chemical binding]; other site 693970011294 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 693970011295 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 693970011296 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 693970011297 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693970011298 N-terminal plug; other site 693970011299 ligand-binding site [chemical binding]; other site 693970011300 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 693970011301 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 693970011302 alanine racemase; Reviewed; Region: alr; PRK00053 693970011303 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 693970011304 active site 693970011305 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693970011306 substrate binding site [chemical binding]; other site 693970011307 catalytic residues [active] 693970011308 dimer interface [polypeptide binding]; other site 693970011309 replicative DNA helicase; Provisional; Region: PRK08006 693970011310 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 693970011311 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 693970011312 Walker A motif; other site 693970011313 ATP binding site [chemical binding]; other site 693970011314 Walker B motif; other site 693970011315 DNA binding loops [nucleotide binding] 693970011316 Peptidase S46; Region: Peptidase_S46; pfam10459 693970011317 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693970011318 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 693970011319 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 693970011320 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 693970011321 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 693970011322 primosomal replication protein N; Provisional; Region: PRK02801 693970011323 generic binding surface II; other site 693970011324 generic binding surface I; other site 693970011325 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 693970011326 Protein of unknown function, DUF481; Region: DUF481; pfam04338 693970011327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970011328 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693970011329 putative substrate translocation pore; other site 693970011330 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 693970011331 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 693970011332 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 693970011333 exoribonuclease R; Provisional; Region: PRK11642 693970011334 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 693970011335 RNB domain; Region: RNB; pfam00773 693970011336 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 693970011337 RNA binding site [nucleotide binding]; other site 693970011338 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693970011339 Sel1 repeat; Region: Sel1; cl02723 693970011340 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 693970011341 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 693970011342 GDP-binding site [chemical binding]; other site 693970011343 ACT binding site; other site 693970011344 IMP binding site; other site 693970011345 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 693970011346 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 693970011347 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 693970011348 23S rRNA interface [nucleotide binding]; other site 693970011349 L3 interface [polypeptide binding]; other site 693970011350 Predicted ATPase [General function prediction only]; Region: COG1485 693970011351 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 693970011352 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693970011353 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693970011354 protein binding site [polypeptide binding]; other site 693970011355 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693970011356 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 693970011357 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693970011358 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693970011359 protein binding site [polypeptide binding]; other site 693970011360 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 693970011361 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 693970011362 hinge; other site 693970011363 active site 693970011364 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 693970011365 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 693970011366 anti sigma factor interaction site; other site 693970011367 regulatory phosphorylation site [posttranslational modification]; other site 693970011368 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 693970011369 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 693970011370 mce related protein; Region: MCE; pfam02470 693970011371 conserved hypothetical integral membrane protein; Region: TIGR00056 693970011372 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 693970011373 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 693970011374 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 693970011375 Walker A/P-loop; other site 693970011376 ATP binding site [chemical binding]; other site 693970011377 Q-loop/lid; other site 693970011378 ABC transporter signature motif; other site 693970011379 Walker B; other site 693970011380 D-loop; other site 693970011381 H-loop/switch region; other site 693970011382 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 693970011383 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 693970011384 putative active site [active] 693970011385 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 693970011386 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 693970011387 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693970011388 active site 693970011389 motif I; other site 693970011390 motif II; other site 693970011391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 693970011392 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 693970011393 OstA-like protein; Region: OstA; cl00844 693970011394 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 693970011395 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 693970011396 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 693970011397 Walker A/P-loop; other site 693970011398 ATP binding site [chemical binding]; other site 693970011399 Q-loop/lid; other site 693970011400 ABC transporter signature motif; other site 693970011401 Walker B; other site 693970011402 D-loop; other site 693970011403 H-loop/switch region; other site 693970011404 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 693970011405 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 693970011406 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 693970011407 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 693970011408 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 693970011409 30S subunit binding site; other site 693970011410 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693970011411 active site 693970011412 phosphorylation site [posttranslational modification] 693970011413 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 693970011414 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 693970011415 dimerization domain swap beta strand [polypeptide binding]; other site 693970011416 regulatory protein interface [polypeptide binding]; other site 693970011417 active site 693970011418 regulatory phosphorylation site [posttranslational modification]; other site 693970011419 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 693970011420 MgtE intracellular N domain; Region: MgtE_N; smart00924 693970011421 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 693970011422 Divalent cation transporter; Region: MgtE; pfam01769 693970011423 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 693970011424 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 693970011425 putative outer membrane lipoprotein; Provisional; Region: PRK10510 693970011426 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693970011427 ligand binding site [chemical binding]; other site 693970011428 Transposase; Region: HTH_Tnp_1; cl17663 693970011429 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 693970011430 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 693970011431 ATP binding site [chemical binding]; other site 693970011432 lipoprotein; Provisional; Region: PRK11443 693970011433 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 693970011434 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 693970011435 active site 693970011436 GAF domain; Region: GAF; pfam01590 693970011437 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970011438 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970011439 metal binding site [ion binding]; metal-binding site 693970011440 active site 693970011441 I-site; other site 693970011442 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970011443 Transposase; Region: HTH_Tnp_1; cl17663 693970011444 Winged helix-turn helix; Region: HTH_29; pfam13551 693970011445 Homeodomain-like domain; Region: HTH_32; pfam13565 693970011446 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970011447 Integrase core domain; Region: rve; pfam00665 693970011448 Integrase core domain; Region: rve_3; pfam13683 693970011449 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970011450 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970011451 Integrase core domain; Region: rve; pfam00665 693970011452 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970011453 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970011454 Integrase core domain; Region: rve; pfam00665 693970011455 LysE type translocator; Region: LysE; cl00565 693970011456 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693970011457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693970011458 Helix-turn-helix domain; Region: HTH_18; pfam12833 693970011459 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693970011460 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 693970011461 dimer interface [polypeptide binding]; other site 693970011462 Alkaline phosphatase homologues; Region: alkPPc; smart00098 693970011463 active site 693970011464 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 693970011465 dimer interface [polypeptide binding]; other site 693970011466 Alkaline phosphatase homologues; Region: alkPPc; smart00098 693970011467 active site 693970011468 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693970011469 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 693970011470 putative active site [active] 693970011471 heme pocket [chemical binding]; other site 693970011472 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970011473 PAS domain; Region: PAS_9; pfam13426 693970011474 putative active site [active] 693970011475 heme pocket [chemical binding]; other site 693970011476 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970011477 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970011478 metal binding site [ion binding]; metal-binding site 693970011479 active site 693970011480 I-site; other site 693970011481 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 693970011482 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693970011483 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 693970011484 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 693970011485 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 693970011486 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 693970011487 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693970011488 DNA-binding site [nucleotide binding]; DNA binding site 693970011489 RNA-binding motif; other site 693970011490 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 693970011491 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 693970011492 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 693970011493 DNA binding residues [nucleotide binding] 693970011494 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 693970011495 Zn binding site [ion binding]; other site 693970011496 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 693970011497 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970011498 ATP binding site [chemical binding]; other site 693970011499 Q-loop/lid; other site 693970011500 ABC transporter signature motif; other site 693970011501 Walker B; other site 693970011502 D-loop; other site 693970011503 H-loop/switch region; other site 693970011504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970011505 Walker A/P-loop; other site 693970011506 ATP binding site [chemical binding]; other site 693970011507 Q-loop/lid; other site 693970011508 ABC transporter signature motif; other site 693970011509 Walker B; other site 693970011510 D-loop; other site 693970011511 H-loop/switch region; other site 693970011512 Protein of unknown function (DUF2999); Region: DUF2999; pfam11212 693970011513 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 693970011514 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970011515 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970011516 metal binding site [ion binding]; metal-binding site 693970011517 active site 693970011518 I-site; other site 693970011519 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 693970011520 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970011521 AAA domain; Region: AAA_23; pfam13476 693970011522 Walker A/P-loop; other site 693970011523 ATP binding site [chemical binding]; other site 693970011524 AAA domain; Region: AAA_21; pfam13304 693970011525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970011526 ABC transporter signature motif; other site 693970011527 Walker B; other site 693970011528 D-loop; other site 693970011529 H-loop/switch region; other site 693970011530 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 693970011531 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 693970011532 ring oligomerisation interface [polypeptide binding]; other site 693970011533 ATP/Mg binding site [chemical binding]; other site 693970011534 stacking interactions; other site 693970011535 hinge regions; other site 693970011536 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 693970011537 oligomerisation interface [polypeptide binding]; other site 693970011538 mobile loop; other site 693970011539 roof hairpin; other site 693970011540 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693970011541 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693970011542 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970011543 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970011544 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693970011545 putative effector binding pocket; other site 693970011546 dimerization interface [polypeptide binding]; other site 693970011547 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693970011548 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970011549 Integrase core domain; Region: rve; pfam00665 693970011550 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970011551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970011552 Walker A motif; other site 693970011553 ATP binding site [chemical binding]; other site 693970011554 Walker B motif; other site 693970011555 HsdM N-terminal domain; Region: HsdM_N; pfam12161 693970011556 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 693970011557 Methyltransferase domain; Region: Methyltransf_26; pfam13659 693970011558 AAA domain; Region: AAA_13; pfam13166 693970011559 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 693970011560 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 693970011561 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 693970011562 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 693970011563 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 693970011564 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 693970011565 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 693970011566 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693970011567 ATP binding site [chemical binding]; other site 693970011568 putative Mg++ binding site [ion binding]; other site 693970011569 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 693970011570 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 693970011571 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693970011572 active site 693970011573 catalytic residues [active] 693970011574 DNA binding site [nucleotide binding] 693970011575 Int/Topo IB signature motif; other site 693970011576 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693970011577 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 693970011578 active site 693970011579 DNA binding site [nucleotide binding] 693970011580 Int/Topo IB signature motif; other site 693970011581 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693970011582 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 693970011583 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 693970011584 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 693970011585 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 693970011586 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 693970011587 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 693970011588 DsbD alpha interface [polypeptide binding]; other site 693970011589 catalytic residues [active] 693970011590 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 693970011591 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 693970011592 TrkA-N domain; Region: TrkA_N; pfam02254 693970011593 galactokinase; Provisional; Region: PRK05101 693970011594 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 693970011595 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 693970011596 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 693970011597 active site 693970011598 catalytic residues [active] 693970011599 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 693970011600 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 693970011601 NAD(P) binding site [chemical binding]; other site 693970011602 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 693970011603 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 693970011604 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693970011605 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693970011606 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693970011607 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693970011608 Sel1-like repeats; Region: SEL1; smart00671 693970011609 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693970011610 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693970011611 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970011612 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 693970011613 Leucine rich repeat; Region: LRR_8; pfam13855 693970011614 Substrate binding site [chemical binding]; other site 693970011615 Leucine rich repeat; Region: LRR_8; pfam13855 693970011616 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 693970011617 active site 693970011618 ATP binding site [chemical binding]; other site 693970011619 substrate binding site [chemical binding]; other site 693970011620 activation loop (A-loop); other site 693970011621 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 693970011622 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693970011623 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693970011624 catalytic residue [active] 693970011625 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693970011626 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693970011627 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970011628 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970011629 Integrase core domain; Region: rve; pfam00665 693970011630 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 693970011631 Part of AAA domain; Region: AAA_19; pfam13245 693970011632 AAA domain; Region: AAA_12; pfam13087 693970011633 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693970011634 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693970011635 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693970011636 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693970011637 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693970011638 Chorismate mutase type II; Region: CM_2; cl00693 693970011639 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 693970011640 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693970011641 substrate binding pocket [chemical binding]; other site 693970011642 membrane-bound complex binding site; other site 693970011643 hinge residues; other site 693970011644 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 693970011645 active site 693970011646 homodimer interface [polypeptide binding]; other site 693970011647 homotetramer interface [polypeptide binding]; other site 693970011648 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970011649 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970011650 Integrase core domain; Region: rve; pfam00665 693970011651 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 693970011652 Aspartase; Region: Aspartase; cd01357 693970011653 active sites [active] 693970011654 tetramer interface [polypeptide binding]; other site 693970011655 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 693970011656 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 693970011657 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13554 693970011658 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 693970011659 Iron-sulfur protein interface; other site 693970011660 proximal heme binding site [chemical binding]; other site 693970011661 distal heme binding site [chemical binding]; other site 693970011662 dimer interface [polypeptide binding]; other site 693970011663 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 693970011664 L-aspartate oxidase; Provisional; Region: PRK06175 693970011665 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 693970011666 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 693970011667 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 693970011668 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693970011669 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693970011670 eyelet of channel; other site 693970011671 trimer interface [polypeptide binding]; other site 693970011672 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 693970011673 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693970011674 dimer interface [polypeptide binding]; other site 693970011675 ssDNA binding site [nucleotide binding]; other site 693970011676 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693970011677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970011678 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693970011679 putative substrate translocation pore; other site 693970011680 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 693970011681 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 693970011682 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 693970011683 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 693970011684 M28 Zn-Peptidases; Region: M28_like_2; cd05662 693970011685 Peptidase family M28; Region: Peptidase_M28; pfam04389 693970011686 metal binding site [ion binding]; metal-binding site 693970011687 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 693970011688 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693970011689 ATP binding site [chemical binding]; other site 693970011690 Mg++ binding site [ion binding]; other site 693970011691 motif III; other site 693970011692 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970011693 nucleotide binding region [chemical binding]; other site 693970011694 ATP-binding site [chemical binding]; other site 693970011695 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 693970011696 putative RNA binding site [nucleotide binding]; other site 693970011697 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 693970011698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693970011699 active site 693970011700 motif I; other site 693970011701 motif II; other site 693970011702 rarD protein; Region: rarD; TIGR00688 693970011703 EamA-like transporter family; Region: EamA; pfam00892 693970011704 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 693970011705 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 693970011706 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970011707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970011708 Walker A motif; other site 693970011709 ATP binding site [chemical binding]; other site 693970011710 Walker B motif; other site 693970011711 Integrase core domain; Region: rve; pfam00665 693970011712 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 693970011713 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 693970011714 Cytochrome c; Region: Cytochrom_C; cl11414 693970011715 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693970011716 Cytochrome c; Region: Cytochrom_C; pfam00034 693970011717 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 693970011718 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 693970011719 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693970011720 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970011721 transcriptional regulator SlyA; Provisional; Region: PRK03573 693970011722 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 693970011723 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693970011724 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970011725 dimerization interface [polypeptide binding]; other site 693970011726 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693970011727 dimer interface [polypeptide binding]; other site 693970011728 putative CheW interface [polypeptide binding]; other site 693970011729 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 693970011730 FAD binding site [chemical binding]; other site 693970011731 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 693970011732 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 693970011733 nucleotide binding site [chemical binding]; other site 693970011734 substrate binding site [chemical binding]; other site 693970011735 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 693970011736 O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080 693970011737 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693970011738 homodimer interface [polypeptide binding]; other site 693970011739 substrate-cofactor binding pocket; other site 693970011740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970011741 catalytic residue [active] 693970011742 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 693970011743 dimerization interface [polypeptide binding]; other site 693970011744 DNA binding site [nucleotide binding] 693970011745 corepressor binding sites; other site 693970011746 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693970011747 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 693970011748 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 693970011749 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 693970011750 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693970011751 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 693970011752 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 693970011753 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 693970011754 putative hydrophobic ligand binding site [chemical binding]; other site 693970011755 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 693970011756 ATP binding site [chemical binding]; other site 693970011757 active site 693970011758 substrate binding site [chemical binding]; other site 693970011759 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 693970011760 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693970011761 Zn2+ binding site [ion binding]; other site 693970011762 Mg2+ binding site [ion binding]; other site 693970011763 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693970011764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970011765 ATP binding site [chemical binding]; other site 693970011766 Mg2+ binding site [ion binding]; other site 693970011767 G-X-G motif; other site 693970011768 Integrase core domain; Region: rve; pfam00665 693970011769 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970011770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970011771 Walker A motif; other site 693970011772 ATP binding site [chemical binding]; other site 693970011773 Walker B motif; other site 693970011774 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 693970011775 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693970011776 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693970011777 ligand binding site [chemical binding]; other site 693970011778 flexible hinge region; other site 693970011779 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 693970011780 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 693970011781 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 693970011782 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693970011783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970011784 S-adenosylmethionine binding site [chemical binding]; other site 693970011785 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970011786 Uncharacterized conserved protein [Function unknown]; Region: COG2968 693970011787 oxidative stress defense protein; Provisional; Region: PRK11087 693970011788 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 693970011789 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 693970011790 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693970011791 FeS/SAM binding site; other site 693970011792 fumarate hydratase; Reviewed; Region: fumC; PRK00485 693970011793 Class II fumarases; Region: Fumarase_classII; cd01362 693970011794 active site 693970011795 tetramer interface [polypeptide binding]; other site 693970011796 Domain of unknown function; Region: DUF331; pfam03889 693970011797 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693970011798 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693970011799 substrate binding pocket [chemical binding]; other site 693970011800 membrane-bound complex binding site; other site 693970011801 hinge residues; other site 693970011802 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 693970011803 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970011804 peptidase PmbA; Provisional; Region: PRK11040 693970011805 hypothetical protein; Provisional; Region: PRK05255 693970011806 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 693970011807 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693970011808 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 693970011809 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 693970011810 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 693970011811 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 693970011812 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 693970011813 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 693970011814 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 693970011815 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 693970011816 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 693970011817 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693970011818 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970011819 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 693970011820 protease TldD; Provisional; Region: tldD; PRK10735 693970011821 nitrilase; Region: PLN02798 693970011822 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 693970011823 putative active site [active] 693970011824 catalytic triad [active] 693970011825 dimer interface [polypeptide binding]; other site 693970011826 TIGR02099 family protein; Region: TIGR02099 693970011827 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 693970011828 ribonuclease G; Provisional; Region: PRK11712 693970011829 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 693970011830 homodimer interface [polypeptide binding]; other site 693970011831 oligonucleotide binding site [chemical binding]; other site 693970011832 Maf-like protein; Region: Maf; pfam02545 693970011833 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 693970011834 active site 693970011835 dimer interface [polypeptide binding]; other site 693970011836 rod shape-determining protein MreD; Region: MreD; cl01087 693970011837 rod shape-determining protein MreC; Region: mreC; TIGR00219 693970011838 rod shape-determining protein MreC; Region: MreC; pfam04085 693970011839 rod shape-determining protein MreB; Provisional; Region: PRK13927 693970011840 MreB and similar proteins; Region: MreB_like; cd10225 693970011841 nucleotide binding site [chemical binding]; other site 693970011842 Mg binding site [ion binding]; other site 693970011843 putative protofilament interaction site [polypeptide binding]; other site 693970011844 RodZ interaction site [polypeptide binding]; other site 693970011845 VcfQ bacterial pilus biogenesis protein, lectin domain; Region: lectin_VcfQ; cd06900 693970011846 putative metal binding site [ion binding]; other site 693970011847 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 693970011848 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 693970011849 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 693970011850 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693970011851 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693970011852 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 693970011853 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 693970011854 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 693970011855 Walker A motif; other site 693970011856 ATP binding site [chemical binding]; other site 693970011857 Walker B motif; other site 693970011858 Tetratricopeptide repeat; Region: TPR_16; pfam13432 693970011859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970011860 TPR motif; other site 693970011861 binding surface 693970011862 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693970011863 binding surface 693970011864 TPR motif; other site 693970011865 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 693970011866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970011867 Walker A motif; other site 693970011868 ATP binding site [chemical binding]; other site 693970011869 Walker B motif; other site 693970011870 arginine finger; other site 693970011871 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 693970011872 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 693970011873 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 693970011874 regulatory protein CsrD; Provisional; Region: PRK11059 693970011875 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970011876 metal binding site [ion binding]; metal-binding site 693970011877 active site 693970011878 I-site; other site 693970011879 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970011880 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 693970011881 Malic enzyme, N-terminal domain; Region: malic; pfam00390 693970011882 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 693970011883 putative NAD(P) binding site [chemical binding]; other site 693970011884 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 693970011885 FimV N-terminal domain; Region: FimV_core; TIGR03505 693970011886 primosome assembly protein PriA; Validated; Region: PRK05580 693970011887 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693970011888 ATP binding site [chemical binding]; other site 693970011889 putative Mg++ binding site [ion binding]; other site 693970011890 helicase superfamily c-terminal domain; Region: HELICc; smart00490 693970011891 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 693970011892 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 693970011893 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 693970011894 active site 693970011895 HIGH motif; other site 693970011896 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 693970011897 KMSK motif region; other site 693970011898 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 693970011899 tRNA binding surface [nucleotide binding]; other site 693970011900 anticodon binding site; other site 693970011901 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 693970011902 Sporulation related domain; Region: SPOR; pfam05036 693970011903 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 693970011904 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 693970011905 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 693970011906 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 693970011907 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 693970011908 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 693970011909 uridine phosphorylase; Provisional; Region: PRK11178 693970011910 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 693970011911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 693970011912 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 693970011913 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 693970011914 dimer interface [polypeptide binding]; other site 693970011915 active site 693970011916 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693970011917 catalytic residues [active] 693970011918 substrate binding site [chemical binding]; other site 693970011919 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 693970011920 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693970011921 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693970011922 Sel1-like repeats; Region: SEL1; smart00671 693970011923 Sel1-like repeats; Region: SEL1; smart00671 693970011924 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693970011925 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 693970011926 substrate binding pocket [chemical binding]; other site 693970011927 membrane-bound complex binding site; other site 693970011928 hinge residues; other site 693970011929 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 693970011930 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 693970011931 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 693970011932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970011933 ATP binding site [chemical binding]; other site 693970011934 Mg2+ binding site [ion binding]; other site 693970011935 G-X-G motif; other site 693970011936 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 693970011937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970011938 active site 693970011939 phosphorylation site [posttranslational modification] 693970011940 intermolecular recognition site; other site 693970011941 dimerization interface [polypeptide binding]; other site 693970011942 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693970011943 DNA binding residues [nucleotide binding] 693970011944 dimerization interface [polypeptide binding]; other site 693970011945 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 693970011946 RibD C-terminal domain; Region: RibD_C; cl17279 693970011947 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 693970011948 active site 693970011949 HslU subunit interaction site [polypeptide binding]; other site 693970011950 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 693970011951 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970011952 Walker A motif; other site 693970011953 ATP binding site [chemical binding]; other site 693970011954 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 693970011955 Walker B motif; other site 693970011956 arginine finger; other site 693970011957 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 693970011958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 693970011959 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970011960 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970011961 Integrase core domain; Region: rve; pfam00665 693970011962 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 693970011963 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 693970011964 C factor cell-cell signaling protein; Provisional; Region: PRK09009 693970011965 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 693970011966 NADP binding site [chemical binding]; other site 693970011967 homodimer interface [polypeptide binding]; other site 693970011968 active site 693970011969 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 693970011970 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 693970011971 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 693970011972 active site 693970011973 Zn binding site [ion binding]; other site 693970011974 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693970011975 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 693970011976 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 693970011977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970011978 active site 693970011979 phosphorylation site [posttranslational modification] 693970011980 intermolecular recognition site; other site 693970011981 dimerization interface [polypeptide binding]; other site 693970011982 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693970011983 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693970011984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970011985 ATP binding site [chemical binding]; other site 693970011986 Mg2+ binding site [ion binding]; other site 693970011987 G-X-G motif; other site 693970011988 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 693970011989 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 693970011990 NADP binding site [chemical binding]; other site 693970011991 active site 693970011992 putative substrate binding site [chemical binding]; other site 693970011993 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 693970011994 metal binding site [ion binding]; metal-binding site 693970011995 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 693970011996 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 693970011997 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693970011998 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 693970011999 probable active site [active] 693970012000 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 693970012001 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693970012002 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693970012003 N-terminal plug; other site 693970012004 ligand-binding site [chemical binding]; other site 693970012005 Domain of unknown function (DUF386); Region: DUF386; cl01047 693970012006 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 693970012007 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 693970012008 DHHA2 domain; Region: DHHA2; pfam02833 693970012009 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 693970012010 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 693970012011 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 693970012012 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 693970012013 nucleophilic elbow; other site 693970012014 catalytic triad; other site 693970012015 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 693970012016 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693970012017 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 693970012018 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 693970012019 active site 693970012020 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 693970012021 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 693970012022 putative active site [active] 693970012023 putative metal binding site [ion binding]; other site 693970012024 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 693970012025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970012026 S-adenosylmethionine binding site [chemical binding]; other site 693970012027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 693970012028 SCP-2 sterol transfer family; Region: SCP2; pfam02036 693970012029 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 693970012030 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 693970012031 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 693970012032 sec-independent translocase; Provisional; Region: PRK01770 693970012033 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 693970012034 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 693970012035 active site 693970012036 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 693970012037 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 693970012038 hypothetical protein; Region: PHA02277 693970012039 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970012040 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970012041 metal binding site [ion binding]; metal-binding site 693970012042 active site 693970012043 I-site; other site 693970012044 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 693970012045 dimer interface [polypeptide binding]; other site 693970012046 allosteric magnesium binding site [ion binding]; other site 693970012047 active site 693970012048 aspartate-rich active site metal binding site; other site 693970012049 Schiff base residues; other site 693970012050 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 693970012051 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 693970012052 substrate binding site [chemical binding]; other site 693970012053 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 693970012054 substrate binding site [chemical binding]; other site 693970012055 ligand binding site [chemical binding]; other site 693970012056 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 693970012057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693970012058 motif II; other site 693970012059 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 693970012060 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 693970012061 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 693970012062 active site 693970012063 Zn binding site [ion binding]; other site 693970012064 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 693970012065 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 693970012066 active site 693970012067 nucleophile elbow; other site 693970012068 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693970012069 Surface antigen; Region: Bac_surface_Ag; pfam01103 693970012070 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 693970012071 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970012072 heme pocket [chemical binding]; other site 693970012073 putative active site [active] 693970012074 PAS fold; Region: PAS_3; pfam08447 693970012075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970012076 PAS domain; Region: PAS_9; pfam13426 693970012077 putative active site [active] 693970012078 heme pocket [chemical binding]; other site 693970012079 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970012080 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970012081 metal binding site [ion binding]; metal-binding site 693970012082 active site 693970012083 I-site; other site 693970012084 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970012085 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 693970012086 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693970012087 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693970012088 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 693970012089 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 693970012090 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693970012091 E3 interaction surface; other site 693970012092 lipoyl attachment site [posttranslational modification]; other site 693970012093 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693970012094 E3 interaction surface; other site 693970012095 lipoyl attachment site [posttranslational modification]; other site 693970012096 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693970012097 E3 interaction surface; other site 693970012098 lipoyl attachment site [posttranslational modification]; other site 693970012099 e3 binding domain; Region: E3_binding; pfam02817 693970012100 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693970012101 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 693970012102 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 693970012103 dimer interface [polypeptide binding]; other site 693970012104 TPP-binding site [chemical binding]; other site 693970012105 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 693970012106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693970012107 DNA-binding site [nucleotide binding]; DNA binding site 693970012108 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693970012109 regulatory protein AmpE; Provisional; Region: PRK10987 693970012110 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 693970012111 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 693970012112 amidase catalytic site [active] 693970012113 Zn binding residues [ion binding]; other site 693970012114 substrate binding site [chemical binding]; other site 693970012115 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 693970012116 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 693970012117 dimerization interface [polypeptide binding]; other site 693970012118 active site 693970012119 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 693970012120 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 693970012121 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 693970012122 Walker A motif; other site 693970012123 ATP binding site [chemical binding]; other site 693970012124 Walker B motif; other site 693970012125 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 693970012126 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693970012127 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693970012128 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 693970012129 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 693970012130 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 693970012131 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 693970012132 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 693970012133 CoA-binding site [chemical binding]; other site 693970012134 ATP-binding [chemical binding]; other site 693970012135 hypothetical protein; Provisional; Region: PRK05287 693970012136 Domain of unknown function (DUF329); Region: DUF329; pfam03884 693970012137 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 693970012138 active site 693970012139 8-oxo-dGMP binding site [chemical binding]; other site 693970012140 nudix motif; other site 693970012141 metal binding site [ion binding]; metal-binding site 693970012142 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693970012143 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693970012144 catalytic residues [active] 693970012145 exopolyphosphatase; Region: exo_poly_only; TIGR03706 693970012146 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 693970012147 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 693970012148 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693970012149 ATP binding site [chemical binding]; other site 693970012150 Mg++ binding site [ion binding]; other site 693970012151 motif III; other site 693970012152 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970012153 nucleotide binding region [chemical binding]; other site 693970012154 ATP-binding site [chemical binding]; other site 693970012155 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693970012156 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693970012157 catalytic residues [active] 693970012158 transcription termination factor Rho; Provisional; Region: rho; PRK09376 693970012159 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 693970012160 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 693970012161 RNA binding site [nucleotide binding]; other site 693970012162 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 693970012163 multimer interface [polypeptide binding]; other site 693970012164 Walker A motif; other site 693970012165 ATP binding site [chemical binding]; other site 693970012166 Walker B motif; other site 693970012167 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693970012168 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970012169 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693970012170 putative effector binding pocket; other site 693970012171 dimerization interface [polypeptide binding]; other site 693970012172 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 693970012173 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 693970012174 putative NAD(P) binding site [chemical binding]; other site 693970012175 dimer interface [polypeptide binding]; other site 693970012176 Uncharacterized conserved protein [Function unknown]; Region: COG1359 693970012177 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 693970012178 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 693970012179 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 693970012180 L-aspartate oxidase; Provisional; Region: PRK06175 693970012181 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 693970012182 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 693970012183 Iron-sulfur protein interface; other site 693970012184 proximal heme binding site [chemical binding]; other site 693970012185 distal heme binding site [chemical binding]; other site 693970012186 dimer interface [polypeptide binding]; other site 693970012187 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13554 693970012188 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 693970012189 Iron-sulfur protein interface; other site 693970012190 proximal heme binding site [chemical binding]; other site 693970012191 distal heme binding site [chemical binding]; other site 693970012192 dimer interface [polypeptide binding]; other site 693970012193 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 693970012194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970012195 S-adenosylmethionine binding site [chemical binding]; other site 693970012196 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 693970012197 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 693970012198 FMN binding site [chemical binding]; other site 693970012199 active site 693970012200 catalytic residues [active] 693970012201 substrate binding site [chemical binding]; other site 693970012202 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 693970012203 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 693970012204 Part of AAA domain; Region: AAA_19; pfam13245 693970012205 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693970012206 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693970012207 Integrase core domain; Region: rve; pfam00665 693970012208 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970012209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970012210 Walker A motif; other site 693970012211 ATP binding site [chemical binding]; other site 693970012212 Walker B motif; other site 693970012213 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 693970012214 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 693970012215 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 693970012216 ligand binding site [chemical binding]; other site 693970012217 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970012218 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970012219 Integrase core domain; Region: rve; pfam00665 693970012220 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 693970012221 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693970012222 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693970012223 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693970012224 DNA binding residues [nucleotide binding] 693970012225 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 693970012226 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 693970012227 Flagellar protein FliS; Region: FliS; cl00654 693970012228 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 693970012229 flagellar capping protein; Reviewed; Region: fliD; PRK08032 693970012230 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 693970012231 flagellin; Provisional; Region: PRK12802 693970012232 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693970012233 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693970012234 flagellin; Provisional; Region: PRK12802 693970012235 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693970012236 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693970012237 flagellin; Provisional; Region: PRK12802 693970012238 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693970012239 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693970012240 flagellin; Provisional; Region: PRK12802 693970012241 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693970012242 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693970012243 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 693970012244 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693970012245 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 693970012246 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693970012247 peptidoglycan hydrolase; Reviewed; Region: flgJ; PRK12708 693970012248 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 693970012249 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 693970012250 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 693970012251 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 693970012252 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 693970012253 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693970012254 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693970012255 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 693970012256 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693970012257 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 693970012258 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 693970012259 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693970012260 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 693970012261 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693970012262 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 693970012263 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 693970012264 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 693970012265 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693970012266 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 693970012267 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 693970012268 SAF-like; Region: SAF_2; pfam13144 693970012269 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 693970012270 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 693970012271 FlgN protein; Region: FlgN; pfam05130 693970012272 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 693970012273 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 693970012274 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693970012275 Walker A motif; other site 693970012276 ATP binding site [chemical binding]; other site 693970012277 Walker B motif; other site 693970012278 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 693970012279 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 693970012280 Flagellar assembly protein FliH; Region: FliH; pfam02108 693970012281 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 693970012282 FliG C-terminal domain; Region: FliG_C; pfam01706 693970012283 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 693970012284 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 693970012285 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 693970012286 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 693970012287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 693970012288 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 693970012289 active site 693970012290 dimerization interface [polypeptide binding]; other site 693970012291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970012292 Walker A motif; other site 693970012293 ATP binding site [chemical binding]; other site 693970012294 Walker B motif; other site 693970012295 arginine finger; other site 693970012296 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693970012297 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 693970012298 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 693970012299 flagellar motor switch protein FliN; Region: fliN; TIGR02480 693970012300 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 693970012301 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 693970012302 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 693970012303 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 693970012304 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 693970012305 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 693970012306 FHIPEP family; Region: FHIPEP; pfam00771 693970012307 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 693970012308 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 693970012309 Hemerythrin-like domain; Region: Hr-like; cd12108 693970012310 Divergent AAA domain; Region: AAA_4; pfam04326 693970012311 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 693970012312 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 693970012313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693970012314 motif II; other site 693970012315 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 693970012316 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 693970012317 active site 693970012318 Int/Topo IB signature motif; other site 693970012319 Protein of unknown function, DUF484; Region: DUF484; cl17449 693970012320 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 693970012321 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 693970012322 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 693970012323 diaminopimelate decarboxylase; Region: lysA; TIGR01048 693970012324 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 693970012325 active site 693970012326 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693970012327 substrate binding site [chemical binding]; other site 693970012328 catalytic residues [active] 693970012329 dimer interface [polypeptide binding]; other site 693970012330 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 693970012331 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 693970012332 putative iron binding site [ion binding]; other site 693970012333 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 693970012334 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 693970012335 domain interfaces; other site 693970012336 active site 693970012337 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 693970012338 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 693970012339 active site 693970012340 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 693970012341 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 693970012342 HemY protein N-terminus; Region: HemY_N; pfam07219 693970012343 VCBS repeat; Region: VCBS_repeat; TIGR01965 693970012344 VCBS repeat; Region: VCBS_repeat; TIGR01965 693970012345 VCBS repeat; Region: VCBS_repeat; TIGR01965 693970012346 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 693970012347 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 693970012348 metal ion-dependent adhesion site (MIDAS); other site 693970012349 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 693970012350 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 693970012351 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 693970012352 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 693970012353 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693970012354 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 693970012355 Walker A/P-loop; other site 693970012356 ATP binding site [chemical binding]; other site 693970012357 Q-loop/lid; other site 693970012358 ABC transporter signature motif; other site 693970012359 Walker B; other site 693970012360 D-loop; other site 693970012361 H-loop/switch region; other site 693970012362 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 693970012363 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693970012364 HlyD family secretion protein; Region: HlyD_3; pfam13437 693970012365 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 693970012366 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 693970012367 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693970012368 ligand binding site [chemical binding]; other site 693970012369 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 693970012370 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693970012371 dimerization interface [polypeptide binding]; other site 693970012372 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970012373 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970012374 metal binding site [ion binding]; metal-binding site 693970012375 active site 693970012376 I-site; other site 693970012377 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970012378 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 693970012379 Part of AAA domain; Region: AAA_19; pfam13245 693970012380 Family description; Region: UvrD_C_2; pfam13538 693970012381 Membrane fusogenic activity; Region: BMFP; pfam04380 693970012382 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 693970012383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 693970012384 inner membrane protein; Provisional; Region: PRK11715 693970012385 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 693970012386 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 693970012387 active site 693970012388 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693970012389 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693970012390 substrate binding pocket [chemical binding]; other site 693970012391 membrane-bound complex binding site; other site 693970012392 hinge residues; other site 693970012393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693970012394 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693970012395 putative DNA binding site [nucleotide binding]; other site 693970012396 putative Zn2+ binding site [ion binding]; other site 693970012397 AsnC family; Region: AsnC_trans_reg; pfam01037 693970012398 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 693970012399 Na2 binding site [ion binding]; other site 693970012400 putative substrate binding site 1 [chemical binding]; other site 693970012401 Na binding site 1 [ion binding]; other site 693970012402 putative substrate binding site 2 [chemical binding]; other site 693970012403 Tim44-like domain; Region: Tim44; pfam04280 693970012404 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 693970012405 homodimer interface [polypeptide binding]; other site 693970012406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970012407 catalytic residue [active] 693970012408 threonine dehydratase; Reviewed; Region: PRK09224 693970012409 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 693970012410 tetramer interface [polypeptide binding]; other site 693970012411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970012412 catalytic residue [active] 693970012413 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 693970012414 putative Ile/Val binding site [chemical binding]; other site 693970012415 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 693970012416 putative Ile/Val binding site [chemical binding]; other site 693970012417 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 693970012418 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 693970012419 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 693970012420 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693970012421 PYR/PP interface [polypeptide binding]; other site 693970012422 dimer interface [polypeptide binding]; other site 693970012423 TPP binding site [chemical binding]; other site 693970012424 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693970012425 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 693970012426 TPP-binding site [chemical binding]; other site 693970012427 dimer interface [polypeptide binding]; other site 693970012428 ketol-acid reductoisomerase; Validated; Region: PRK05225 693970012429 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 693970012430 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 693970012431 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 693970012432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970012433 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 693970012434 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 693970012435 putative dimerization interface [polypeptide binding]; other site 693970012436 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 693970012437 Domain of unknown function DUF21; Region: DUF21; pfam01595 693970012438 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693970012439 Transporter associated domain; Region: CorC_HlyC; smart01091 693970012440 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 693970012441 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693970012442 substrate binding pocket [chemical binding]; other site 693970012443 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693970012444 GAF domain; Region: GAF; pfam01590 693970012445 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970012446 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970012447 metal binding site [ion binding]; metal-binding site 693970012448 active site 693970012449 I-site; other site 693970012450 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693970012451 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693970012452 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970012453 Transposase; Region: HTH_Tnp_1; pfam01527 693970012454 putative transposase OrfB; Reviewed; Region: PHA02517 693970012455 HTH-like domain; Region: HTH_21; pfam13276 693970012456 Integrase core domain; Region: rve; pfam00665 693970012457 Integrase core domain; Region: rve_3; pfam13683 693970012458 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693970012459 Helix-turn-helix domain; Region: HTH_38; pfam13936 693970012460 Integrase core domain; Region: rve; pfam00665 693970012461 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 693970012462 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 693970012463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970012464 Walker A motif; other site 693970012465 ATP binding site [chemical binding]; other site 693970012466 Walker B motif; other site 693970012467 arginine finger; other site 693970012468 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 693970012469 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 693970012470 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 693970012471 putative acyl-acceptor binding pocket; other site 693970012472 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 693970012473 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 693970012474 putative acyl-acceptor binding pocket; other site 693970012475 Uncharacterized conserved protein [Function unknown]; Region: COG1683 693970012476 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693970012477 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693970012478 DNA-binding site [nucleotide binding]; DNA binding site 693970012479 FCD domain; Region: FCD; pfam07729 693970012480 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 693970012481 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 693970012482 tetramer interface [polypeptide binding]; other site 693970012483 active site 693970012484 Mg2+/Mn2+ binding site [ion binding]; other site 693970012485 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 693970012486 dimer interface [polypeptide binding]; other site 693970012487 Citrate synthase; Region: Citrate_synt; pfam00285 693970012488 active site 693970012489 citrylCoA binding site [chemical binding]; other site 693970012490 oxalacetate/citrate binding site [chemical binding]; other site 693970012491 coenzyme A binding site [chemical binding]; other site 693970012492 catalytic triad [active] 693970012493 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 693970012494 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 693970012495 substrate binding site [chemical binding]; other site 693970012496 ligand binding site [chemical binding]; other site 693970012497 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 693970012498 substrate binding site [chemical binding]; other site 693970012499 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 693970012500 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 693970012501 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 693970012502 tetramer interface [polypeptide binding]; other site 693970012503 active site 693970012504 Mg2+/Mn2+ binding site [ion binding]; other site 693970012505 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 693970012506 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 693970012507 PAS fold; Region: PAS_3; pfam08447 693970012508 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970012509 PAS domain; Region: PAS_9; pfam13426 693970012510 putative active site [active] 693970012511 heme pocket [chemical binding]; other site 693970012512 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970012513 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970012514 metal binding site [ion binding]; metal-binding site 693970012515 active site 693970012516 I-site; other site 693970012517 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970012518 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 693970012519 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 693970012520 homodimer interface [polypeptide binding]; other site 693970012521 substrate-cofactor binding pocket; other site 693970012522 catalytic residue [active] 693970012523 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; pfam07073 693970012524 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 693970012525 homotrimer interaction site [polypeptide binding]; other site 693970012526 putative active site [active] 693970012527 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 693970012528 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 693970012529 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 693970012530 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 693970012531 catalytic residues [active] 693970012532 hinge region; other site 693970012533 alpha helical domain; other site 693970012534 serine/threonine protein kinase; Provisional; Region: PRK11768 693970012535 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 693970012536 Protein of unknown function (DUF3630); Region: DUF3630; pfam12305 693970012537 Uncharacterized conserved protein [Function unknown]; Region: COG0397 693970012538 hypothetical protein; Validated; Region: PRK00029 693970012539 DsrE/DsrF-like family; Region: DrsE; cl00672 693970012540 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 693970012541 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 693970012542 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 693970012543 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693970012544 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693970012545 DNA-binding site [nucleotide binding]; DNA binding site 693970012546 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693970012547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970012548 homodimer interface [polypeptide binding]; other site 693970012549 catalytic residue [active] 693970012550 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 693970012551 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693970012552 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 693970012553 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693970012554 catalytic residues [active] 693970012555 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 693970012556 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693970012557 catalytic residues [active] 693970012558 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 693970012559 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 693970012560 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 693970012561 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 693970012562 DsbD alpha interface [polypeptide binding]; other site 693970012563 catalytic residues [active] 693970012564 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970012565 Coenzyme A binding pocket [chemical binding]; other site 693970012566 Acyltransferase family; Region: Acyl_transf_3; pfam01757 693970012567 Uncharacterized conserved protein [Function unknown]; Region: COG3339 693970012568 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693970012569 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693970012570 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 693970012571 substrate binding site [chemical binding]; other site 693970012572 Protein of unknown function (DUF2618); Region: DUF2618; pfam10940 693970012573 ornithine decarboxylase; Provisional; Region: PRK13578 693970012574 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 693970012575 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 693970012576 homodimer interface [polypeptide binding]; other site 693970012577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970012578 catalytic residue [active] 693970012579 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 693970012580 putrescine transporter; Provisional; Region: potE; PRK10655 693970012581 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693970012582 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693970012583 trimer interface [polypeptide binding]; other site 693970012584 eyelet of channel; other site 693970012585 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 693970012586 Shikimate kinase; Region: SKI; pfam01202 693970012587 ATP-binding site [chemical binding]; other site 693970012588 Gluconate-6-phosphate binding site [chemical binding]; other site 693970012589 low affinity gluconate transporter; Provisional; Region: PRK10472 693970012590 GntP family permease; Region: GntP_permease; pfam02447 693970012591 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 693970012592 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693970012593 DNA binding site [nucleotide binding] 693970012594 domain linker motif; other site 693970012595 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 693970012596 putative ligand binding site [chemical binding]; other site 693970012597 putative dimerization interface [polypeptide binding]; other site 693970012598 hypothetical protein; Provisional; Region: PRK01254 693970012599 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 693970012600 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 693970012601 MAPEG family; Region: MAPEG; cl09190 693970012602 Uncharacterized conserved protein [Function unknown]; Region: COG2966 693970012603 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 693970012604 Uncharacterized conserved protein [Function unknown]; Region: COG3610 693970012605 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 693970012606 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 693970012607 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 693970012608 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 693970012609 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 693970012610 putative SAM binding site [chemical binding]; other site 693970012611 putative homodimer interface [polypeptide binding]; other site 693970012612 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 693970012613 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 693970012614 putative ligand binding site [chemical binding]; other site 693970012615 hypothetical protein; Reviewed; Region: PRK12497 693970012616 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 693970012617 dimer interface [polypeptide binding]; other site 693970012618 active site 693970012619 outer membrane lipoprotein; Provisional; Region: PRK11023 693970012620 BON domain; Region: BON; pfam04972 693970012621 BON domain; Region: BON; pfam04972 693970012622 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693970012623 EamA-like transporter family; Region: EamA; pfam00892 693970012624 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693970012625 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693970012626 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693970012627 dimerization interface [polypeptide binding]; other site 693970012628 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 693970012629 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 693970012630 active site 693970012631 HIGH motif; other site 693970012632 dimer interface [polypeptide binding]; other site 693970012633 KMSKS motif; other site 693970012634 phosphoglycolate phosphatase; Provisional; Region: PRK13222 693970012635 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 693970012636 motif I; other site 693970012637 active site 693970012638 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693970012639 motif II; other site 693970012640 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 693970012641 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 693970012642 substrate binding site [chemical binding]; other site 693970012643 hexamer interface [polypeptide binding]; other site 693970012644 metal binding site [ion binding]; metal-binding site 693970012645 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 693970012646 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 693970012647 AAA ATPase domain; Region: AAA_16; pfam13191 693970012648 AAA domain; Region: AAA_22; pfam13401 693970012649 Walker A motif; other site 693970012650 ATP binding site [chemical binding]; other site 693970012651 Walker B motif; other site 693970012652 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 693970012653 active site 693970012654 dimer interface [polypeptide binding]; other site 693970012655 metal binding site [ion binding]; metal-binding site 693970012656 shikimate kinase; Reviewed; Region: aroK; PRK00131 693970012657 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 693970012658 ADP binding site [chemical binding]; other site 693970012659 magnesium binding site [ion binding]; other site 693970012660 putative shikimate binding site; other site 693970012661 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 693970012662 Secretin and TonB N terminus short domain; Region: STN; smart00965 693970012663 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 693970012664 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 693970012665 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 693970012666 Pilus assembly protein, PilP; Region: PilP; pfam04351 693970012667 Pilus assembly protein, PilO; Region: PilO; pfam04350 693970012668 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 693970012669 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 693970012670 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693970012671 Competence protein A; Region: Competence_A; pfam11104 693970012672 nucleotide binding site [chemical binding]; other site 693970012673 Cell division protein FtsA; Region: FtsA; pfam14450 693970012674 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 693970012675 Transglycosylase; Region: Transgly; pfam00912 693970012676 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 693970012677 argininosuccinate lyase; Provisional; Region: PRK04833 693970012678 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 693970012679 active sites [active] 693970012680 tetramer interface [polypeptide binding]; other site 693970012681 argininosuccinate synthase; Provisional; Region: PRK13820 693970012682 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 693970012683 ANP binding site [chemical binding]; other site 693970012684 Substrate Binding Site II [chemical binding]; other site 693970012685 Substrate Binding Site I [chemical binding]; other site 693970012686 ornithine carbamoyltransferase; Provisional; Region: PRK14805 693970012687 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 693970012688 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 693970012689 acetylglutamate kinase; Provisional; Region: PRK00942 693970012690 nucleotide binding site [chemical binding]; other site 693970012691 substrate binding site [chemical binding]; other site 693970012692 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 693970012693 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 693970012694 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 693970012695 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 693970012696 Protein of unknown function (DUF1439); Region: DUF1439; pfam07273 693970012697 competence damage-inducible protein A; Provisional; Region: PRK00549 693970012698 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 693970012699 putative MPT binding site; other site 693970012700 Competence-damaged protein; Region: CinA; pfam02464 693970012701 putative acetyltransferase; Provisional; Region: PRK03624 693970012702 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970012703 Coenzyme A binding pocket [chemical binding]; other site 693970012704 Helix-turn-helix domain; Region: HTH_17; pfam12728 693970012705 PBP superfamily domain; Region: PBP_like; pfam12727 693970012706 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 693970012707 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 693970012708 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 693970012709 Ferredoxin [Energy production and conversion]; Region: COG1146 693970012710 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 693970012711 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693970012712 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 693970012713 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 693970012714 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 693970012715 [4Fe-4S] binding site [ion binding]; other site 693970012716 molybdopterin cofactor binding site; other site 693970012717 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693970012718 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 693970012719 molybdopterin cofactor binding site; other site 693970012720 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 693970012721 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 693970012722 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 693970012723 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 693970012724 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 693970012725 [4Fe-4S] binding site [ion binding]; other site 693970012726 molybdopterin cofactor binding site; other site 693970012727 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693970012728 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 693970012729 molybdopterin cofactor binding site; other site 693970012730 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 693970012731 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 693970012732 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 693970012733 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693970012734 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693970012735 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 693970012736 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 693970012737 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 693970012738 alphaNTD homodimer interface [polypeptide binding]; other site 693970012739 alphaNTD - beta interaction site [polypeptide binding]; other site 693970012740 alphaNTD - beta' interaction site [polypeptide binding]; other site 693970012741 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 693970012742 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 693970012743 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 693970012744 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693970012745 RNA binding surface [nucleotide binding]; other site 693970012746 30S ribosomal protein S11; Validated; Region: PRK05309 693970012747 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 693970012748 30S ribosomal protein S13; Region: bact_S13; TIGR03631 693970012749 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 693970012750 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 693970012751 SecY translocase; Region: SecY; pfam00344 693970012752 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 693970012753 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 693970012754 23S rRNA binding site [nucleotide binding]; other site 693970012755 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 693970012756 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 693970012757 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 693970012758 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 693970012759 23S rRNA interface [nucleotide binding]; other site 693970012760 L21e interface [polypeptide binding]; other site 693970012761 5S rRNA interface [nucleotide binding]; other site 693970012762 L27 interface [polypeptide binding]; other site 693970012763 L5 interface [polypeptide binding]; other site 693970012764 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 693970012765 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 693970012766 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 693970012767 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 693970012768 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 693970012769 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 693970012770 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 693970012771 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 693970012772 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 693970012773 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 693970012774 RNA binding site [nucleotide binding]; other site 693970012775 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 693970012776 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 693970012777 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 693970012778 23S rRNA interface [nucleotide binding]; other site 693970012779 putative translocon interaction site; other site 693970012780 signal recognition particle (SRP54) interaction site; other site 693970012781 L23 interface [polypeptide binding]; other site 693970012782 trigger factor interaction site; other site 693970012783 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 693970012784 23S rRNA interface [nucleotide binding]; other site 693970012785 5S rRNA interface [nucleotide binding]; other site 693970012786 putative antibiotic binding site [chemical binding]; other site 693970012787 L25 interface [polypeptide binding]; other site 693970012788 L27 interface [polypeptide binding]; other site 693970012789 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 693970012790 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 693970012791 G-X-X-G motif; other site 693970012792 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 693970012793 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 693970012794 putative translocon binding site; other site 693970012795 protein-rRNA interface [nucleotide binding]; other site 693970012796 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 693970012797 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 693970012798 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 693970012799 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 693970012800 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 693970012801 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 693970012802 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 693970012803 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 693970012804 elongation factor Tu; Reviewed; Region: PRK00049 693970012805 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 693970012806 G1 box; other site 693970012807 GEF interaction site [polypeptide binding]; other site 693970012808 GTP/Mg2+ binding site [chemical binding]; other site 693970012809 Switch I region; other site 693970012810 G2 box; other site 693970012811 G3 box; other site 693970012812 Switch II region; other site 693970012813 G4 box; other site 693970012814 G5 box; other site 693970012815 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 693970012816 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 693970012817 Antibiotic Binding Site [chemical binding]; other site 693970012818 elongation factor G; Reviewed; Region: PRK00007 693970012819 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 693970012820 G1 box; other site 693970012821 putative GEF interaction site [polypeptide binding]; other site 693970012822 GTP/Mg2+ binding site [chemical binding]; other site 693970012823 Switch I region; other site 693970012824 G2 box; other site 693970012825 G3 box; other site 693970012826 Switch II region; other site 693970012827 G4 box; other site 693970012828 G5 box; other site 693970012829 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 693970012830 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 693970012831 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 693970012832 30S ribosomal protein S7; Validated; Region: PRK05302 693970012833 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 693970012834 S17 interaction site [polypeptide binding]; other site 693970012835 S8 interaction site; other site 693970012836 16S rRNA interaction site [nucleotide binding]; other site 693970012837 streptomycin interaction site [chemical binding]; other site 693970012838 23S rRNA interaction site [nucleotide binding]; other site 693970012839 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 693970012840 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 693970012841 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 693970012842 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 693970012843 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 693970012844 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 693970012845 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 693970012846 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 693970012847 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 693970012848 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 693970012849 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 693970012850 DNA binding site [nucleotide binding] 693970012851 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 693970012852 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 693970012853 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 693970012854 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 693970012855 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 693970012856 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 693970012857 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 693970012858 RPB3 interaction site [polypeptide binding]; other site 693970012859 RPB1 interaction site [polypeptide binding]; other site 693970012860 RPB11 interaction site [polypeptide binding]; other site 693970012861 RPB10 interaction site [polypeptide binding]; other site 693970012862 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 693970012863 core dimer interface [polypeptide binding]; other site 693970012864 peripheral dimer interface [polypeptide binding]; other site 693970012865 L10 interface [polypeptide binding]; other site 693970012866 L11 interface [polypeptide binding]; other site 693970012867 putative EF-Tu interaction site [polypeptide binding]; other site 693970012868 putative EF-G interaction site [polypeptide binding]; other site 693970012869 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 693970012870 23S rRNA interface [nucleotide binding]; other site 693970012871 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 693970012872 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 693970012873 mRNA/rRNA interface [nucleotide binding]; other site 693970012874 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 693970012875 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 693970012876 23S rRNA interface [nucleotide binding]; other site 693970012877 L7/L12 interface [polypeptide binding]; other site 693970012878 putative thiostrepton binding site; other site 693970012879 L25 interface [polypeptide binding]; other site 693970012880 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 693970012881 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 693970012882 putative homodimer interface [polypeptide binding]; other site 693970012883 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 693970012884 heterodimer interface [polypeptide binding]; other site 693970012885 homodimer interface [polypeptide binding]; other site 693970012886 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 693970012887 elongation factor Tu; Reviewed; Region: PRK00049 693970012888 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 693970012889 G1 box; other site 693970012890 GEF interaction site [polypeptide binding]; other site 693970012891 GTP/Mg2+ binding site [chemical binding]; other site 693970012892 Switch I region; other site 693970012893 G2 box; other site 693970012894 G3 box; other site 693970012895 Switch II region; other site 693970012896 G4 box; other site 693970012897 G5 box; other site 693970012898 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 693970012899 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 693970012900 Antibiotic Binding Site [chemical binding]; other site 693970012901 pantothenate kinase; Provisional; Region: PRK05439 693970012902 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 693970012903 ATP-binding site [chemical binding]; other site 693970012904 CoA-binding site [chemical binding]; other site 693970012905 Mg2+-binding site [ion binding]; other site 693970012906 Biotin operon repressor [Transcription]; Region: BirA; COG1654 693970012907 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 693970012908 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 693970012909 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 693970012910 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 693970012911 FAD binding domain; Region: FAD_binding_4; pfam01565 693970012912 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 693970012913 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 693970012914 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 693970012915 glutamate racemase; Provisional; Region: PRK00865 693970012916 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 693970012917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970012918 S-adenosylmethionine binding site [chemical binding]; other site 693970012919 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 693970012920 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693970012921 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 693970012922 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 693970012923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693970012924 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 693970012925 Fatty acid desaturase; Region: FA_desaturase; pfam00487 693970012926 Di-iron ligands [ion binding]; other site 693970012927 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 693970012928 selenophosphate synthetase; Provisional; Region: PRK00943 693970012929 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 693970012930 dimerization interface [polypeptide binding]; other site 693970012931 putative ATP binding site [chemical binding]; other site 693970012932 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 693970012933 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 693970012934 active site residue [active] 693970012935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970012936 putative substrate translocation pore; other site 693970012937 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 693970012938 putative acyl-acceptor binding pocket; other site 693970012939 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693970012940 WHG domain; Region: WHG; pfam13305 693970012941 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693970012942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970012943 Coenzyme A binding pocket [chemical binding]; other site 693970012944 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 693970012945 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 693970012946 active site 693970012947 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 693970012948 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 693970012949 dimer interface [polypeptide binding]; other site 693970012950 ADP-ribose binding site [chemical binding]; other site 693970012951 active site 693970012952 nudix motif; other site 693970012953 metal binding site [ion binding]; metal-binding site 693970012954 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 693970012955 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 693970012956 Interdomain contacts; other site 693970012957 Cytokine receptor motif; other site 693970012958 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 693970012959 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 693970012960 Cadherin repeat-like domain; Region: CA_like; cl15786 693970012961 Ca2+ binding site [ion binding]; other site 693970012962 Cadherin repeat-like domain; Region: CA_like; cl15786 693970012963 Ca2+ binding site [ion binding]; other site 693970012964 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 693970012965 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 693970012966 Phage Tail Collar Domain; Region: Collar; pfam07484 693970012967 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693970012968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693970012969 Coenzyme A binding pocket [chemical binding]; other site 693970012970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970012971 S-adenosylmethionine binding site [chemical binding]; other site 693970012972 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 693970012973 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 693970012974 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 693970012975 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693970012976 motif II; other site 693970012977 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 693970012978 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 693970012979 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 693970012980 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 693970012981 GspL periplasmic domain; Region: GspL_C; pfam12693 693970012982 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 693970012983 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 693970012984 type II secretion system protein J; Region: gspJ; TIGR01711 693970012985 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 693970012986 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 693970012987 type II secretion system protein I; Region: gspI; TIGR01707 693970012988 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 693970012989 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 693970012990 Type II transport protein GspH; Region: GspH; pfam12019 693970012991 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 693970012992 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 693970012993 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 693970012994 type II secretion system protein F; Region: GspF; TIGR02120 693970012995 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693970012996 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693970012997 type II secretion system protein E; Region: type_II_gspE; TIGR02533 693970012998 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 693970012999 Walker A motif; other site 693970013000 ATP binding site [chemical binding]; other site 693970013001 Walker B motif; other site 693970013002 type II secretion system protein D; Region: type_II_gspD; TIGR02517 693970013003 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 693970013004 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 693970013005 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 693970013006 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 693970013007 putative type II secretion protein GspC; Provisional; Region: PRK09681 693970013008 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 693970013009 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 693970013010 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693970013011 RNA binding surface [nucleotide binding]; other site 693970013012 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 693970013013 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 693970013014 dimerization interface [polypeptide binding]; other site 693970013015 domain crossover interface; other site 693970013016 redox-dependent activation switch; other site 693970013017 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 693970013018 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 693970013019 active site 693970013020 substrate-binding site [chemical binding]; other site 693970013021 metal-binding site [ion binding] 693970013022 ATP binding site [chemical binding]; other site 693970013023 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693970013024 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 693970013025 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 693970013026 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 693970013027 putative active site [active] 693970013028 Zn binding site [ion binding]; other site 693970013029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970013030 S-adenosylmethionine binding site [chemical binding]; other site 693970013031 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 693970013032 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 693970013033 GIY-YIG motif/motif A; other site 693970013034 putative active site [active] 693970013035 putative metal binding site [ion binding]; other site 693970013036 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 693970013037 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 693970013038 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693970013039 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 693970013040 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 693970013041 Nitrate and nitrite sensing; Region: NIT; pfam08376 693970013042 HAMP domain; Region: HAMP; pfam00672 693970013043 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693970013044 PAS domain; Region: PAS_9; pfam13426 693970013045 putative active site [active] 693970013046 heme pocket [chemical binding]; other site 693970013047 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693970013048 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693970013049 metal binding site [ion binding]; metal-binding site 693970013050 active site 693970013051 I-site; other site 693970013052 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693970013053 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 693970013054 Ferritin-like domain; Region: Ferritin; pfam00210 693970013055 ferroxidase diiron center [ion binding]; other site 693970013056 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 693970013057 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 693970013058 dimer interface [polypeptide binding]; other site 693970013059 putative functional site; other site 693970013060 putative MPT binding site; other site 693970013061 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 693970013062 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 693970013063 ATP binding site [chemical binding]; other site 693970013064 substrate interface [chemical binding]; other site 693970013065 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 693970013066 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 693970013067 Domain of unknown function (DUF333); Region: DUF333; pfam03891 693970013068 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 693970013069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970013070 S-adenosylmethionine binding site [chemical binding]; other site 693970013071 flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697 693970013072 Chorismate lyase; Region: Chor_lyase; cl01230 693970013073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 693970013074 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 693970013075 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 693970013076 putative antibiotic transporter; Provisional; Region: PRK10739 693970013077 NRDE protein; Region: NRDE; cl01315 693970013078 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 693970013079 SnoaL-like domain; Region: SnoaL_3; pfam13474 693970013080 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 693970013081 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 693970013082 putative acyl-acceptor binding pocket; other site 693970013083 LysE type translocator; Region: LysE; cl00565 693970013084 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 693970013085 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693970013086 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 693970013087 Protein of unknown function (DUF3157); Region: DUF3157; pfam11355 693970013088 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693970013089 Peptidase family M23; Region: Peptidase_M23; pfam01551 693970013090 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693970013091 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 693970013092 Peptidase family M48; Region: Peptidase_M48; cl12018 693970013093 Pilin (bacterial filament); Region: Pilin; pfam00114 693970013094 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 693970013095 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693970013096 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693970013097 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693970013098 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693970013099 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 693970013100 AzlC protein; Region: AzlC; cl00570 693970013101 transaminase; Validated; Region: PRK07324 693970013102 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693970013103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693970013104 homodimer interface [polypeptide binding]; other site 693970013105 catalytic residue [active] 693970013106 Biofilm formation and stress response factor; Region: BsmA; pfam10014 693970013107 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 693970013108 active sites [active] 693970013109 tetramer interface [polypeptide binding]; other site 693970013110 urocanate hydratase; Provisional; Region: PRK05414 693970013111 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 693970013112 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693970013113 DNA-binding site [nucleotide binding]; DNA binding site 693970013114 UTRA domain; Region: UTRA; pfam07702 693970013115 imidazolonepropionase; Validated; Region: PRK09356 693970013116 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 693970013117 active site 693970013118 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 693970013119 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 693970013120 FAD binding pocket [chemical binding]; other site 693970013121 FAD binding motif [chemical binding]; other site 693970013122 phosphate binding motif [ion binding]; other site 693970013123 NAD binding pocket [chemical binding]; other site 693970013124 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693970013125 MarR family; Region: MarR_2; pfam12802 693970013126 MarR family; Region: MarR_2; cl17246 693970013127 Lamin Tail Domain; Region: LTD; pfam00932 693970013128 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693970013129 Endonuclease I; Region: Endonuclease_1; pfam04231 693970013130 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 693970013131 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 693970013132 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 693970013133 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 693970013134 putative active site [active] 693970013135 catalytic site [active] 693970013136 putative metal binding site [ion binding]; other site 693970013137 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 693970013138 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 693970013139 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 693970013140 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 693970013141 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693970013142 DNA binding residues [nucleotide binding] 693970013143 putative dimer interface [polypeptide binding]; other site 693970013144 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693970013145 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693970013146 active site 693970013147 Protein of unknown function (DUF3233); Region: DUF3233; pfam11557 693970013148 HPP family; Region: HPP; pfam04982 693970013149 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693970013150 active site 693970013151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693970013152 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 693970013153 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 693970013154 acyl-activating enzyme (AAE) consensus motif; other site 693970013155 putative AMP binding site [chemical binding]; other site 693970013156 putative active site [active] 693970013157 putative CoA binding site [chemical binding]; other site 693970013158 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693970013159 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693970013160 Walker A/P-loop; other site 693970013161 ATP binding site [chemical binding]; other site 693970013162 Q-loop/lid; other site 693970013163 ABC transporter signature motif; other site 693970013164 Walker B; other site 693970013165 D-loop; other site 693970013166 H-loop/switch region; other site 693970013167 Predicted transcriptional regulators [Transcription]; Region: COG1725 693970013168 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693970013169 DNA-binding site [nucleotide binding]; DNA binding site 693970013170 TAP-like protein; Region: Abhydrolase_4; pfam08386 693970013171 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 693970013172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970013173 Walker A/P-loop; other site 693970013174 ATP binding site [chemical binding]; other site 693970013175 Q-loop/lid; other site 693970013176 ABC transporter signature motif; other site 693970013177 Walker B; other site 693970013178 D-loop; other site 693970013179 H-loop/switch region; other site 693970013180 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 693970013181 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 693970013182 Phage shock protein B; Region: PspB; cl05946 693970013183 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 693970013184 Transglycosylase; Region: Transgly; pfam00912 693970013185 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 693970013186 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 693970013187 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 693970013188 MG2 domain; Region: A2M_N; pfam01835 693970013189 Alpha-2-macroglobulin family; Region: A2M; pfam00207 693970013190 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 693970013191 surface patch; other site 693970013192 thioester region; other site 693970013193 specificity defining residues; other site 693970013194 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 693970013195 MPT binding site; other site 693970013196 trimer interface [polypeptide binding]; other site 693970013197 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693970013198 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 693970013199 putative substrate binding site [chemical binding]; other site 693970013200 putative ATP binding site [chemical binding]; other site 693970013201 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693970013202 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 693970013203 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693970013204 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 693970013205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970013206 putative substrate translocation pore; other site 693970013207 sucrose phosphorylase; Provisional; Region: PRK13840 693970013208 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 693970013209 active site 693970013210 homodimer interface [polypeptide binding]; other site 693970013211 catalytic site [active] 693970013212 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693970013213 Transposase; Region: HTH_Tnp_1; pfam01527 693970013214 putative transposase OrfB; Reviewed; Region: PHA02517 693970013215 HTH-like domain; Region: HTH_21; pfam13276 693970013216 Integrase core domain; Region: rve; pfam00665 693970013217 Integrase core domain; Region: rve_3; pfam13683 693970013218 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693970013219 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693970013220 DNA binding site [nucleotide binding] 693970013221 domain linker motif; other site 693970013222 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 693970013223 putative dimerization interface [polypeptide binding]; other site 693970013224 putative ligand binding site [chemical binding]; other site 693970013225 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 693970013226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693970013227 putative substrate translocation pore; other site 693970013228 NlpC/P60 family; Region: NLPC_P60; pfam00877 693970013229 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693970013230 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 693970013231 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 693970013232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970013233 active site 693970013234 phosphorylation site [posttranslational modification] 693970013235 intermolecular recognition site; other site 693970013236 dimerization interface [polypeptide binding]; other site 693970013237 LytTr DNA-binding domain; Region: LytTR; pfam04397 693970013238 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 693970013239 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 693970013240 GAF domain; Region: GAF_3; pfam13492 693970013241 Histidine kinase; Region: His_kinase; pfam06580 693970013242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970013243 ATP binding site [chemical binding]; other site 693970013244 Mg2+ binding site [ion binding]; other site 693970013245 G-X-G motif; other site 693970013246 Pirin-related protein [General function prediction only]; Region: COG1741 693970013247 Pirin; Region: Pirin; pfam02678 693970013248 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 693970013249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693970013250 dimer interface [polypeptide binding]; other site 693970013251 phosphorylation site [posttranslational modification] 693970013252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693970013253 ATP binding site [chemical binding]; other site 693970013254 Mg2+ binding site [ion binding]; other site 693970013255 G-X-G motif; other site 693970013256 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693970013257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693970013258 active site 693970013259 phosphorylation site [posttranslational modification] 693970013260 intermolecular recognition site; other site 693970013261 dimerization interface [polypeptide binding]; other site 693970013262 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693970013263 DNA binding site [nucleotide binding] 693970013264 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 693970013265 TrkA-N domain; Region: TrkA_N; pfam02254 693970013266 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 693970013267 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 693970013268 Transposase; Region: HTH_Tnp_1; cl17663 693970013269 Winged helix-turn helix; Region: HTH_29; pfam13551 693970013270 Homeodomain-like domain; Region: HTH_32; pfam13565 693970013271 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970013272 Integrase core domain; Region: rve; pfam00665 693970013273 Integrase core domain; Region: rve_3; pfam13683 693970013274 Integrase core domain; Region: rve; pfam00665 693970013275 AAA domain; Region: AAA_22; pfam13401 693970013276 AAA ATPase domain; Region: AAA_16; pfam13191 693970013277 Walker A motif; other site 693970013278 ATP binding site [chemical binding]; other site 693970013279 Walker B motif; other site 693970013280 Transposase; Region: HTH_Tnp_1; cl17663 693970013281 Winged helix-turn helix; Region: HTH_29; pfam13551 693970013282 Homeodomain-like domain; Region: HTH_32; pfam13565 693970013283 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970013284 Integrase core domain; Region: rve; pfam00665 693970013285 Integrase core domain; Region: rve_3; pfam13683 693970013286 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 693970013287 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 693970013288 HI0933-like protein; Region: HI0933_like; pfam03486 693970013289 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693970013290 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 693970013291 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 693970013292 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 693970013293 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 693970013294 SecA binding site; other site 693970013295 Preprotein binding site; other site 693970013296 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 693970013297 active site residue [active] 693970013298 phosphoglyceromutase; Provisional; Region: PRK05434 693970013299 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 693970013300 AmiB activator; Provisional; Region: PRK11637 693970013301 Peptidase family M23; Region: Peptidase_M23; pfam01551 693970013302 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 693970013303 C-terminal peptidase (prc); Region: prc; TIGR00225 693970013304 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 693970013305 protein binding site [polypeptide binding]; other site 693970013306 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 693970013307 Catalytic dyad [active] 693970013308 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 693970013309 putative active site [active] 693970013310 putative catalytic site [active] 693970013311 NodB motif; other site 693970013312 Zn binding site [ion binding]; other site 693970013313 Transcriptional regulator; Region: Rrf2; cl17282 693970013314 Rrf2 family protein; Region: rrf2_super; TIGR00738 693970013315 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 693970013316 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 693970013317 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693970013318 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 693970013319 substrate binding site [chemical binding]; other site 693970013320 oxyanion hole (OAH) forming residues; other site 693970013321 trimer interface [polypeptide binding]; other site 693970013322 Predicted membrane protein [Function unknown]; Region: COG3205 693970013323 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 693970013324 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 693970013325 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693970013326 ATP binding site [chemical binding]; other site 693970013327 putative Mg++ binding site [ion binding]; other site 693970013328 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 693970013329 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 693970013330 DNA protecting protein DprA; Region: dprA; TIGR00732 693970013331 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 693970013332 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693970013333 ATP binding site [chemical binding]; other site 693970013334 putative Mg++ binding site [ion binding]; other site 693970013335 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970013336 nucleotide binding region [chemical binding]; other site 693970013337 ATP-binding site [chemical binding]; other site 693970013338 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693970013339 active site 693970013340 Transposase; Region: HTH_Tnp_1; cl17663 693970013341 Winged helix-turn helix; Region: HTH_29; pfam13551 693970013342 Homeodomain-like domain; Region: HTH_32; pfam13565 693970013343 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693970013344 Integrase core domain; Region: rve; pfam00665 693970013345 Integrase core domain; Region: rve_3; pfam13683 693970013346 HsdM N-terminal domain; Region: HsdM_N; pfam12161 693970013347 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 693970013348 Methyltransferase domain; Region: Methyltransf_26; pfam13659 693970013349 Helix-turn-helix domain; Region: HTH_17; pfam12728 693970013350 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 693970013351 putative active site [active] 693970013352 metal binding site [ion binding]; metal-binding site 693970013353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970013354 salt bridge; other site 693970013355 non-specific DNA binding site [nucleotide binding]; other site 693970013356 sequence-specific DNA binding site [nucleotide binding]; other site 693970013357 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970013358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970013359 Walker A motif; other site 693970013360 ATP binding site [chemical binding]; other site 693970013361 Walker B motif; other site 693970013362 Integrase core domain; Region: rve; pfam00665 693970013363 AAA domain; Region: AAA_22; pfam13401 693970013364 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970013365 Walker A motif; other site 693970013366 ATP binding site [chemical binding]; other site 693970013367 Walker B motif; other site 693970013368 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 693970013369 CAS motifs; other site 693970013370 active site 693970013371 Tn7 transposition regulator TnsC; Region: Tn7_TnsC_Int; pfam11426 693970013372 Integrase core domain; Region: rve; pfam00665 693970013373 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 693970013374 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 693970013375 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 693970013376 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 693970013377 glutaminase active site [active] 693970013378 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 693970013379 dimer interface [polypeptide binding]; other site 693970013380 active site 693970013381 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 693970013382 dimer interface [polypeptide binding]; other site 693970013383 active site 693970013384 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 693970013385 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 693970013386 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693970013387 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 693970013388 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693970013389 N-terminal plug; other site 693970013390 ligand-binding site [chemical binding]; other site 693970013391 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 693970013392 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 693970013393 Substrate binding site; other site 693970013394 Mg++ binding site; other site 693970013395 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 693970013396 active site 693970013397 substrate binding site [chemical binding]; other site 693970013398 CoA binding site [chemical binding]; other site 693970013399 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 693970013400 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 693970013401 gamma subunit interface [polypeptide binding]; other site 693970013402 epsilon subunit interface [polypeptide binding]; other site 693970013403 LBP interface [polypeptide binding]; other site 693970013404 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 693970013405 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 693970013406 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 693970013407 alpha subunit interaction interface [polypeptide binding]; other site 693970013408 Walker A motif; other site 693970013409 ATP binding site [chemical binding]; other site 693970013410 Walker B motif; other site 693970013411 inhibitor binding site; inhibition site 693970013412 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 693970013413 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 693970013414 core domain interface [polypeptide binding]; other site 693970013415 delta subunit interface [polypeptide binding]; other site 693970013416 epsilon subunit interface [polypeptide binding]; other site 693970013417 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 693970013418 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 693970013419 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 693970013420 beta subunit interaction interface [polypeptide binding]; other site 693970013421 Walker A motif; other site 693970013422 ATP binding site [chemical binding]; other site 693970013423 Walker B motif; other site 693970013424 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 693970013425 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 693970013426 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 693970013427 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 693970013428 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 693970013429 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 693970013430 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 693970013431 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 693970013432 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 693970013433 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 693970013434 ParB-like nuclease domain; Region: ParBc; pfam02195 693970013435 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693970013436 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693970013437 P-loop; other site 693970013438 Magnesium ion binding site [ion binding]; other site 693970013439 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693970013440 Magnesium ion binding site [ion binding]; other site 693970013441 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 693970013442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970013443 S-adenosylmethionine binding site [chemical binding]; other site 693970013444 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 693970013445 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 693970013446 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 693970013447 FMN-binding protein MioC; Provisional; Region: PRK09004 693970013448 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 693970013449 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 693970013450 trmE is a tRNA modification GTPase; Region: trmE; cd04164 693970013451 G1 box; other site 693970013452 GTP/Mg2+ binding site [chemical binding]; other site 693970013453 Switch I region; other site 693970013454 G2 box; other site 693970013455 Switch II region; other site 693970013456 G3 box; other site 693970013457 G4 box; other site 693970013458 G5 box; other site 693970013459 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 693970013460 membrane protein insertase; Provisional; Region: PRK01318 693970013461 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 693970013462 Haemolytic domain; Region: Haemolytic; pfam01809 693970013463 ribonuclease P; Reviewed; Region: rnpA; PRK01732 693970013464 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970013465 non-specific DNA binding site [nucleotide binding]; other site 693970013466 salt bridge; other site 693970013467 sequence-specific DNA binding site [nucleotide binding]; other site 693970013468 Putative helicase; Region: TraI_2; pfam07514 693970013469 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693970013470 Zn2+ binding site [ion binding]; other site 693970013471 Mg2+ binding site [ion binding]; other site 693970013472 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 693970013473 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 693970013474 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 693970013475 Abi-like protein; Region: Abi_2; cl01988 693970013476 Superinfection exclusion protein B; Region: SieB; pfam14163 693970013477 Domain of unknown function (DUF3541); Region: DUF3541; pfam12060 693970013478 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693970013479 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 693970013480 catalytic residues [active] 693970013481 catalytic nucleophile [active] 693970013482 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970013483 non-specific DNA binding site [nucleotide binding]; other site 693970013484 salt bridge; other site 693970013485 sequence-specific DNA binding site [nucleotide binding]; other site 693970013486 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970013487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970013488 Walker A motif; other site 693970013489 ATP binding site [chemical binding]; other site 693970013490 Walker B motif; other site 693970013491 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693970013492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693970013493 Walker A motif; other site 693970013494 ATP binding site [chemical binding]; other site 693970013495 Walker B motif; other site 693970013496 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693970013497 active site 693970013498 DNA binding site [nucleotide binding] 693970013499 Int/Topo IB signature motif; other site 693970013500 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 693970013501 Protein of unknown function, DUF417; Region: DUF417; cl01162 693970013502 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693970013503 dimer interface [polypeptide binding]; other site 693970013504 ssDNA binding site [nucleotide binding]; other site 693970013505 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693970013506 DNA topoisomerase III; Provisional; Region: PRK07726 693970013507 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 693970013508 active site 693970013509 putative interdomain interaction site [polypeptide binding]; other site 693970013510 putative metal-binding site [ion binding]; other site 693970013511 putative nucleotide binding site [chemical binding]; other site 693970013512 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 693970013513 domain I; other site 693970013514 DNA binding groove [nucleotide binding] 693970013515 phosphate binding site [ion binding]; other site 693970013516 domain II; other site 693970013517 domain III; other site 693970013518 nucleotide binding site [chemical binding]; other site 693970013519 catalytic site [active] 693970013520 domain IV; other site 693970013521 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 693970013522 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 693970013523 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693970013524 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 693970013525 catalytic residues [active] 693970013526 catalytic nucleophile [active] 693970013527 Presynaptic Site I dimer interface [polypeptide binding]; other site 693970013528 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 693970013529 Synaptic Flat tetramer interface [polypeptide binding]; other site 693970013530 Synaptic Site I dimer interface [polypeptide binding]; other site 693970013531 DNA binding site [nucleotide binding] 693970013532 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 693970013533 DNA-binding interface [nucleotide binding]; DNA binding site 693970013534 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 693970013535 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 693970013536 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 693970013537 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 693970013538 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 693970013539 Type II/IV secretion system protein; Region: T2SE; pfam00437 693970013540 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693970013541 Walker A motif; other site 693970013542 ATP binding site [chemical binding]; other site 693970013543 Walker B motif; other site 693970013544 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 693970013545 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 693970013546 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 693970013547 PemK-like protein; Region: PemK; cl00995 693970013548 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 693970013549 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 693970013550 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 693970013551 integrating conjugative element protein, PFL_4695 family; Region: ICE_PFL_4695; TIGR03765 693970013552 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 693970013553 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 693970013554 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 693970013555 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 693970013556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970013557 non-specific DNA binding site [nucleotide binding]; other site 693970013558 salt bridge; other site 693970013559 sequence-specific DNA binding site [nucleotide binding]; other site 693970013560 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693970013561 active site 693970013562 catalytic residues [active] 693970013563 DNA binding site [nucleotide binding] 693970013564 Int/Topo IB signature motif; other site 693970013565 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693970013566 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970013567 non-specific DNA binding site [nucleotide binding]; other site 693970013568 salt bridge; other site 693970013569 sequence-specific DNA binding site [nucleotide binding]; other site 693970013570 Domain of unknown function (DUF955); Region: DUF955; cl01076 693970013571 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 693970013572 HsdM N-terminal domain; Region: HsdM_N; pfam12161 693970013573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693970013574 S-adenosylmethionine binding site [chemical binding]; other site 693970013575 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 693970013576 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 693970013577 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 693970013578 Fic family protein [Function unknown]; Region: COG3177 693970013579 Fic/DOC family; Region: Fic; pfam02661 693970013580 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 693970013581 non-specific DNA interactions [nucleotide binding]; other site 693970013582 DNA binding site [nucleotide binding] 693970013583 sequence specific DNA binding site [nucleotide binding]; other site 693970013584 putative cAMP binding site [chemical binding]; other site 693970013585 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 693970013586 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 693970013587 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693970013588 ATP binding site [chemical binding]; other site 693970013589 putative Mg++ binding site [ion binding]; other site 693970013590 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 693970013591 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 693970013592 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 693970013593 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 693970013594 Protein of unknown function (DUF2895); Region: DUF2895; cl12968 693970013595 Protein of unknown function (DUF3438); Region: DUF3438; cl13372 693970013596 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 693970013597 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 693970013598 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 693970013599 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 693970013600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693970013601 Walker A/P-loop; other site 693970013602 ATP binding site [chemical binding]; other site 693970013603 TraU protein; Region: TraU; cl06067 693970013604 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 693970013605 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 693970013606 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 693970013607 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693970013608 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693970013609 P-loop; other site 693970013610 Magnesium ion binding site [ion binding]; other site 693970013611 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693970013612 Magnesium ion binding site [ion binding]; other site 693970013613 plasmid-partitioning protein; Provisional; Region: PRK13698 693970013614 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 693970013615 Methyltransferase domain; Region: Methyltransf_26; pfam13659 693970013616 DEAD-like helicases superfamily; Region: DEXDc; smart00487 693970013617 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 693970013618 ATP binding site [chemical binding]; other site 693970013619 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693970013620 nucleotide binding region [chemical binding]; other site 693970013621 ATP-binding site [chemical binding]; other site 693970013622 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 693970013623 Initiator Replication protein; Region: Rep_3; pfam01051 693970013624 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693970013625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970013626 non-specific DNA binding site [nucleotide binding]; other site 693970013627 sequence-specific DNA binding site [nucleotide binding]; other site 693970013628 salt bridge; other site 693970013629 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693970013630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693970013631 non-specific DNA binding site [nucleotide binding]; other site 693970013632 salt bridge; other site 693970013633 sequence-specific DNA binding site [nucleotide binding]; other site