-- dump date   	20140620_063329
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
325240000001	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240000002	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
325240000003	Int/Topo IB signature motif; other site
325240000004	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
325240000005	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
325240000006	active site
325240000007	phosphorylation site [posttranslational modification]
325240000008	intermolecular recognition site; other site
325240000009	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
325240000010	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
325240000011	Zn2+ binding site [ion binding]; other site
325240000012	Mg2+ binding site [ion binding]; other site
325240000013	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
325240000014	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
325240000015	Low-spin heme binding site [chemical binding]; other site
325240000016	Putative water exit pathway; other site
325240000017	Binuclear center (active site) [active]
325240000018	Putative proton exit pathway; other site
325240000019	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
325240000020	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
325240000021	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
325240000022	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
325240000023	Cytochrome c; Region: Cytochrom_C; pfam00034
325240000024	Cytochrome c; Region: Cytochrom_C; pfam00034
325240000025	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
325240000026	FixH; Region: FixH; pfam05751
325240000027	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
325240000028	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
325240000029	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
325240000030	metal-binding site [ion binding]
325240000031	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
325240000032	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
325240000033	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
325240000034	Family description; Region: DsbD_2; pfam13386
325240000035	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
325240000036	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
325240000037	ligand binding site [chemical binding]; other site
325240000038	flexible hinge region; other site
325240000039	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
325240000040	putative switch regulator; other site
325240000041	non-specific DNA interactions [nucleotide binding]; other site
325240000042	DNA binding site [nucleotide binding]
325240000043	sequence specific DNA binding site [nucleotide binding]; other site
325240000044	putative cAMP binding site [chemical binding]; other site
325240000045	universal stress protein UspE; Provisional; Region: PRK11175
325240000046	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
325240000047	Ligand Binding Site [chemical binding]; other site
325240000048	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
325240000049	Ligand Binding Site [chemical binding]; other site
325240000050	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
325240000051	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
325240000052	Ligand Binding Site [chemical binding]; other site
325240000053	Protein of unknown function (DUF2987); Region: DUF2987; pfam11205
325240000054	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
325240000055	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
325240000056	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
325240000057	phosphate binding site [ion binding]; other site
325240000058	putative substrate binding pocket [chemical binding]; other site
325240000059	dimer interface [polypeptide binding]; other site
325240000060	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
325240000061	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
325240000062	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240000063	homodimer interface [polypeptide binding]; other site
325240000064	catalytic residue [active]
325240000065	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
325240000066	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
325240000067	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
325240000068	Protein of unknown function (DUF2989); Region: DUF2989; pfam11207
325240000069	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
325240000070	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
325240000071	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
325240000072	quinolinate synthetase; Provisional; Region: PRK09375
325240000073	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
325240000074	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
325240000075	E3 interaction surface; other site
325240000076	lipoyl attachment site [posttranslational modification]; other site
325240000077	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
325240000078	E3 interaction surface; other site
325240000079	lipoyl attachment site [posttranslational modification]; other site
325240000080	e3 binding domain; Region: E3_binding; pfam02817
325240000081	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
325240000082	3-methyl-2-oxobutanate dehydrogenase; Provisional; Region: PTZ00182
325240000083	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
325240000084	alpha subunit interface [polypeptide binding]; other site
325240000085	TPP binding site [chemical binding]; other site
325240000086	heterodimer interface [polypeptide binding]; other site
325240000087	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
325240000088	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
325240000089	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
325240000090	tetramer interface [polypeptide binding]; other site
325240000091	TPP-binding site [chemical binding]; other site
325240000092	heterodimer interface [polypeptide binding]; other site
325240000093	phosphorylation loop region [posttranslational modification]
325240000094	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
325240000095	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
325240000096	putative active site [active]
325240000097	Zn binding site [ion binding]; other site
325240000098	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
325240000099	phosphoglucomutase; Validated; Region: PRK07564
325240000100	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
325240000101	active site
325240000102	substrate binding site [chemical binding]; other site
325240000103	metal binding site [ion binding]; metal-binding site
325240000104	replication initiation regulator SeqA; Provisional; Region: PRK11187
325240000105	PGAP1-like protein; Region: PGAP1; pfam07819
325240000106	acyl-CoA esterase; Provisional; Region: PRK10673
325240000107	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
325240000108	LexA regulated protein; Provisional; Region: PRK11675
325240000109	flavodoxin FldA; Validated; Region: PRK09267
325240000110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
325240000111	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
325240000112	elongation factor P; Validated; Region: PRK00529
325240000113	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
325240000114	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
325240000115	RNA binding site [nucleotide binding]; other site
325240000116	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
325240000117	RNA binding site [nucleotide binding]; other site
325240000118	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
325240000119	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
325240000120	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
325240000121	Short chain fatty acid transporter; Region: SCFA_trans; cl17380
325240000122	aminotransferase AlaT; Validated; Region: PRK09265
325240000123	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
325240000124	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240000125	homodimer interface [polypeptide binding]; other site
325240000126	catalytic residue [active]
325240000127	5'-nucleotidase; Provisional; Region: PRK03826
325240000128	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
325240000129	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
325240000130	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
325240000131	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
325240000132	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
325240000133	active site
325240000134	intersubunit interface [polypeptide binding]; other site
325240000135	catalytic residue [active]
325240000136	phosphogluconate dehydratase; Validated; Region: PRK09054
325240000137	6-phosphogluconate dehydratase; Region: edd; TIGR01196
325240000138	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
325240000139	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
325240000140	putative active site [active]
325240000141	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
325240000142	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
325240000143	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
325240000144	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
325240000145	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
325240000146	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
325240000147	putative active site [active]
325240000148	pyruvate kinase; Provisional; Region: PRK05826
325240000149	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
325240000150	domain interfaces; other site
325240000151	active site
325240000152	acyl-CoA dehydrogenase; Reviewed; Region: PRK13026
325240000153	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
325240000154	active site
325240000155	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
325240000156	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
325240000157	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
325240000158	Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461
325240000159	active site
325240000160	Zn binding site [ion binding]; other site
325240000161	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
325240000162	Smr domain; Region: Smr; pfam01713
325240000163	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
325240000164	SEC-C motif; Region: SEC-C; pfam02810
325240000165	SEC-C motif; Region: SEC-C; pfam02810
325240000166	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
325240000167	GAF domain; Region: GAF; pfam01590
325240000168	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240000169	PAS domain; Region: PAS_9; pfam13426
325240000170	putative active site [active]
325240000171	heme pocket [chemical binding]; other site
325240000172	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240000173	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240000174	metal binding site [ion binding]; metal-binding site
325240000175	active site
325240000176	I-site; other site
325240000177	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240000178	Protein of unknown function (DUF406); Region: DUF406; pfam04175
325240000179	Ribosomal S4P (gammaproteobacterial); Region: Ribosomal_S4Pg; pfam11993
325240000180	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
325240000181	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
325240000182	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
325240000183	catalytic residue [active]
325240000184	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
325240000185	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
325240000186	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
325240000187	Ligand Binding Site [chemical binding]; other site
325240000188	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
325240000189	excinuclease ABC subunit B; Provisional; Region: PRK05298
325240000190	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
325240000191	ATP binding site [chemical binding]; other site
325240000192	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240000193	nucleotide binding region [chemical binding]; other site
325240000194	ATP-binding site [chemical binding]; other site
325240000195	Ultra-violet resistance protein B; Region: UvrB; pfam12344
325240000196	UvrB/uvrC motif; Region: UVR; pfam02151
325240000197	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240000198	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240000199	active site
325240000200	I-site; other site
325240000201	metal binding site [ion binding]; metal-binding site
325240000202	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240000203	electron transport complex protein RsxA; Provisional; Region: PRK05151
325240000204	ferredoxin; Provisional; Region: PRK08764
325240000205	Putative Fe-S cluster; Region: FeS; pfam04060
325240000206	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
325240000207	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
325240000208	SLBB domain; Region: SLBB; pfam10531
325240000209	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
325240000210	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
325240000211	electron transport complex protein RnfG; Validated; Region: PRK01908
325240000212	electron transport complex RsxE subunit; Provisional; Region: PRK12405
325240000213	endonuclease III; Provisional; Region: PRK10702
325240000214	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
325240000215	minor groove reading motif; other site
325240000216	helix-hairpin-helix signature motif; other site
325240000217	substrate binding pocket [chemical binding]; other site
325240000218	active site
325240000219	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
325240000220	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
325240000221	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240000222	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
325240000223	dimerization interface [polypeptide binding]; other site
325240000224	substrate binding pocket [chemical binding]; other site
325240000225	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
325240000226	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
325240000227	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
325240000228	dimer interface [polypeptide binding]; other site
325240000229	active site
325240000230	metal binding site [ion binding]; metal-binding site
325240000231	glutathione binding site [chemical binding]; other site
325240000232	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
325240000233	TMAO/DMSO reductase; Reviewed; Region: PRK05363
325240000234	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
325240000235	Moco binding site; other site
325240000236	metal coordination site [ion binding]; other site
325240000237	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
325240000238	RmuC family; Region: RmuC; pfam02646
325240000239	lytic murein transglycosylase; Provisional; Region: PRK11619
325240000240	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
325240000241	N-acetyl-D-glucosamine binding site [chemical binding]; other site
325240000242	catalytic residue [active]
325240000243	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240000244	MoxR-like ATPases [General function prediction only]; Region: COG0714
325240000245	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240000246	Walker A motif; other site
325240000247	ATP binding site [chemical binding]; other site
325240000248	Walker B motif; other site
325240000249	arginine finger; other site
325240000250	Protein of unknown function DUF58; Region: DUF58; pfam01882
325240000251	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
325240000252	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
325240000253	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
325240000254	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
325240000255	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
325240000256	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
325240000257	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
325240000258	Part of AAA domain; Region: AAA_19; pfam13245
325240000259	Family description; Region: UvrD_C_2; pfam13538
325240000260	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
325240000261	AAA domain; Region: AAA_30; pfam13604
325240000262	Family description; Region: UvrD_C_2; pfam13538
325240000263	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
325240000264	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240000265	Coenzyme A binding pocket [chemical binding]; other site
325240000266	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240000267	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240000268	metal binding site [ion binding]; metal-binding site
325240000269	active site
325240000270	I-site; other site
325240000271	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
325240000272	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
325240000273	ATP-grasp domain; Region: ATP-grasp_4; cl17255
325240000274	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
325240000275	GAF domain; Region: GAF; pfam01590
325240000276	PAS domain; Region: PAS_9; pfam13426
325240000277	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240000278	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240000279	metal binding site [ion binding]; metal-binding site
325240000280	active site
325240000281	I-site; other site
325240000282	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240000283	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
325240000284	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240000285	S-adenosylmethionine binding site [chemical binding]; other site
325240000286	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
325240000287	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240000288	putative substrate translocation pore; other site
325240000289	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
325240000290	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
325240000291	active site
325240000292	catalytic site [active]
325240000293	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
325240000294	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
325240000295	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
325240000296	ATP binding site [chemical binding]; other site
325240000297	putative Mg++ binding site [ion binding]; other site
325240000298	Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
325240000299	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
325240000300	recombination regulator RecX; Reviewed; Region: recX; PRK00117
325240000301	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
325240000302	Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710
325240000303	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
325240000304	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
325240000305	putative active site [active]
325240000306	putative NTP binding site [chemical binding]; other site
325240000307	putative nucleic acid binding site [nucleotide binding]; other site
325240000308	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
325240000309	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
325240000310	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
325240000311	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
325240000312	ligand binding site [chemical binding]; other site
325240000313	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240000314	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240000315	Integrase core domain; Region: rve; pfam00665
325240000316	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
325240000317	Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767
325240000318	catalytic residues [active]
325240000319	catalytic nucleophile [active]
325240000320	Abi-like protein; Region: Abi_2; pfam07751
325240000321	Domain of unknown function (DUF1845); Region: DUF1845; pfam08900
325240000322	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
325240000323	Integrase core domain; Region: rve; pfam00665
325240000324	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240000325	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240000326	Walker A motif; other site
325240000327	ATP binding site [chemical binding]; other site
325240000328	Walker B motif; other site
325240000329	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
325240000330	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
325240000331	P-loop; other site
325240000332	Magnesium ion binding site [ion binding]; other site
325240000333	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
325240000334	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
325240000335	non-specific DNA binding site [nucleotide binding]; other site
325240000336	salt bridge; other site
325240000337	sequence-specific DNA binding site [nucleotide binding]; other site
325240000338	Predicted transcriptional regulator [Transcription]; Region: COG2932
325240000339	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
325240000340	Catalytic site [active]
325240000341	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
325240000342	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
325240000343	catalytic residues [active]
325240000344	catalytic nucleophile [active]
325240000345	Presynaptic Site I dimer interface [polypeptide binding]; other site
325240000346	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
325240000347	Synaptic Flat tetramer interface [polypeptide binding]; other site
325240000348	Synaptic Site I dimer interface [polypeptide binding]; other site
325240000349	DNA binding site [nucleotide binding]
325240000350	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
325240000351	DNA-binding interface [nucleotide binding]; DNA binding site
325240000352	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
325240000353	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
325240000354	Protein of unknown function (DUF1640); Region: DUF1640; pfam07798
325240000355	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
325240000356	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
325240000357	DNA topoisomerase III; Provisional; Region: PRK07726
325240000358	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
325240000359	active site
325240000360	putative interdomain interaction site [polypeptide binding]; other site
325240000361	putative metal-binding site [ion binding]; other site
325240000362	putative nucleotide binding site [chemical binding]; other site
325240000363	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
325240000364	domain I; other site
325240000365	DNA binding groove [nucleotide binding]
325240000366	phosphate binding site [ion binding]; other site
325240000367	domain II; other site
325240000368	domain III; other site
325240000369	nucleotide binding site [chemical binding]; other site
325240000370	catalytic site [active]
325240000371	domain IV; other site
325240000372	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
325240000373	dimer interface [polypeptide binding]; other site
325240000374	ssDNA binding site [nucleotide binding]; other site
325240000375	tetramer (dimer of dimers) interface [polypeptide binding]; other site
325240000376	Protein of unknown function, DUF417; Region: DUF417; cl01162
325240000377	Protein of unknown function (DUF2913); Region: DUF2913; pfam11140
325240000378	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
325240000379	active site
325240000380	catalytic residues [active]
325240000381	DNA binding site [nucleotide binding]
325240000382	Int/Topo IB signature motif; other site
325240000383	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
325240000384	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
325240000385	DNA binding domain, excisionase family; Region: excise; TIGR01764
325240000386	PIN domain; Region: PIN_3; pfam13470
325240000387	Transposase, Mutator family; Region: Transposase_mut; pfam00872
325240000388	MULE transposase domain; Region: MULE; pfam10551
325240000389	Scavenger mRNA decapping enzyme C-term binding; Region: DcpS_C; pfam11969
325240000390	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
325240000391	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240000392	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240000393	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240000394	Walker A motif; other site
325240000395	ATP binding site [chemical binding]; other site
325240000396	Walker B motif; other site
325240000397	Transposase; Region: HTH_Tnp_1; cl17663
325240000398	Winged helix-turn helix; Region: HTH_29; pfam13551
325240000399	Homeodomain-like domain; Region: HTH_32; pfam13565
325240000400	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
325240000401	Integrase core domain; Region: rve; pfam00665
325240000402	Integrase core domain; Region: rve_3; pfam13683
325240000403	Integrase core domain; Region: rve; pfam00665
325240000404	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240000405	DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341
325240000406	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240000407	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
325240000408	dimerization interface [polypeptide binding]; other site
325240000409	Transposase; Region: HTH_Tnp_1; pfam01527
325240000410	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240000411	putative transposase OrfB; Reviewed; Region: PHA02517
325240000412	HTH-like domain; Region: HTH_21; pfam13276
325240000413	Integrase core domain; Region: rve; pfam00665
325240000414	Integrase core domain; Region: rve_2; pfam13333
325240000415	Transposase; Region: HTH_Tnp_1; pfam01527
325240000416	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240000417	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
325240000418	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
325240000419	NADH(P)-binding; Region: NAD_binding_10; pfam13460
325240000420	NAD(P) binding site [chemical binding]; other site
325240000421	putative active site [active]
325240000422	multiple promoter invertase; Provisional; Region: mpi; PRK13413
325240000423	Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767
325240000424	catalytic residues [active]
325240000425	catalytic nucleophile [active]
325240000426	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
325240000427	HsdM N-terminal domain; Region: HsdM_N; pfam12161
325240000428	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
325240000429	Methyltransferase domain; Region: Methyltransf_26; pfam13659
325240000430	putative transposase OrfB; Reviewed; Region: PHA02517
325240000431	HTH-like domain; Region: HTH_21; pfam13276
325240000432	Integrase core domain; Region: rve; pfam00665
325240000433	Integrase core domain; Region: rve_2; pfam13333
325240000434	Transposase; Region: HTH_Tnp_1; pfam01527
325240000435	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240000436	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
325240000437	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
325240000438	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
325240000439	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
325240000440	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
325240000441	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
325240000442	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
325240000443	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
325240000444	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
325240000445	RPB3 interaction site [polypeptide binding]; other site
325240000446	RPB1 interaction site [polypeptide binding]; other site
325240000447	RPB11 interaction site [polypeptide binding]; other site
325240000448	RPB10 interaction site [polypeptide binding]; other site
325240000449	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
325240000450	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
325240000451	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
325240000452	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
325240000453	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
325240000454	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
325240000455	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
325240000456	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
325240000457	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
325240000458	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
325240000459	DNA binding site [nucleotide binding]
325240000460	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
325240000461	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
325240000462	S17 interaction site [polypeptide binding]; other site
325240000463	S8 interaction site; other site
325240000464	16S rRNA interaction site [nucleotide binding]; other site
325240000465	streptomycin interaction site [chemical binding]; other site
325240000466	23S rRNA interaction site [nucleotide binding]; other site
325240000467	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
325240000468	30S ribosomal protein S7; Validated; Region: PRK05302
325240000469	elongation factor G; Reviewed; Region: PRK00007
325240000470	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
325240000471	G1 box; other site
325240000472	putative GEF interaction site [polypeptide binding]; other site
325240000473	GTP/Mg2+ binding site [chemical binding]; other site
325240000474	Switch I region; other site
325240000475	G2 box; other site
325240000476	G3 box; other site
325240000477	Switch II region; other site
325240000478	G4 box; other site
325240000479	G5 box; other site
325240000480	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
325240000481	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
325240000482	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
325240000483	elongation factor Tu; Reviewed; Region: PRK00049
325240000484	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
325240000485	G1 box; other site
325240000486	GEF interaction site [polypeptide binding]; other site
325240000487	GTP/Mg2+ binding site [chemical binding]; other site
325240000488	Switch I region; other site
325240000489	G2 box; other site
325240000490	G3 box; other site
325240000491	Switch II region; other site
325240000492	G4 box; other site
325240000493	G5 box; other site
325240000494	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
325240000495	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
325240000496	Antibiotic Binding Site [chemical binding]; other site
325240000497	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
325240000498	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
325240000499	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
325240000500	putative homodimer interface [polypeptide binding]; other site
325240000501	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
325240000502	heterodimer interface [polypeptide binding]; other site
325240000503	homodimer interface [polypeptide binding]; other site
325240000504	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
325240000505	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
325240000506	23S rRNA interface [nucleotide binding]; other site
325240000507	L7/L12 interface [polypeptide binding]; other site
325240000508	putative thiostrepton binding site; other site
325240000509	L25 interface [polypeptide binding]; other site
325240000510	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
325240000511	mRNA/rRNA interface [nucleotide binding]; other site
325240000512	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
325240000513	23S rRNA interface [nucleotide binding]; other site
325240000514	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
325240000515	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
325240000516	core dimer interface [polypeptide binding]; other site
325240000517	peripheral dimer interface [polypeptide binding]; other site
325240000518	L10 interface [polypeptide binding]; other site
325240000519	L11 interface [polypeptide binding]; other site
325240000520	putative EF-Tu interaction site [polypeptide binding]; other site
325240000521	putative EF-G interaction site [polypeptide binding]; other site
325240000522	replication initiation protein; Region: II; PHA00360
325240000523	Phage replication protein CRI; Region: Phage_CRI; pfam05144
325240000524	Phage X family; Region: Phage_X; pfam05155
325240000525	putative assembly protein; Region: PHA00350
325240000526	Zonular occludens toxin (Zot); Region: Zot; cl17485
325240000527	DnaA N-terminal domain; Region: DnaA_N; pfam11638
325240000528	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
325240000529	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240000530	Walker A motif; other site
325240000531	ATP binding site [chemical binding]; other site
325240000532	Walker B motif; other site
325240000533	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
325240000534	arginine finger; other site
325240000535	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
325240000536	DnaA box-binding interface [nucleotide binding]; other site
325240000537	DNA polymerase III subunit beta; Validated; Region: PRK05643
325240000538	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
325240000539	putative DNA binding surface [nucleotide binding]; other site
325240000540	dimer interface [polypeptide binding]; other site
325240000541	beta-clamp/clamp loader binding surface; other site
325240000542	beta-clamp/translesion DNA polymerase binding surface; other site
325240000543	recombination protein F; Reviewed; Region: recF; PRK00064
325240000544	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240000545	Walker A/P-loop; other site
325240000546	ATP binding site [chemical binding]; other site
325240000547	Q-loop/lid; other site
325240000548	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240000549	ABC transporter signature motif; other site
325240000550	Walker B; other site
325240000551	D-loop; other site
325240000552	H-loop/switch region; other site
325240000553	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
325240000554	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240000555	ATP binding site [chemical binding]; other site
325240000556	Mg2+ binding site [ion binding]; other site
325240000557	G-X-G motif; other site
325240000558	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
325240000559	anchoring element; other site
325240000560	dimer interface [polypeptide binding]; other site
325240000561	ATP binding site [chemical binding]; other site
325240000562	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
325240000563	active site
325240000564	putative metal-binding site [ion binding]; other site
325240000565	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
325240000566	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
325240000567	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
325240000568	putative C-terminal domain interface [polypeptide binding]; other site
325240000569	putative GSH binding site (G-site) [chemical binding]; other site
325240000570	putative dimer interface [polypeptide binding]; other site
325240000571	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
325240000572	putative N-terminal domain interface [polypeptide binding]; other site
325240000573	putative dimer interface [polypeptide binding]; other site
325240000574	putative substrate binding pocket (H-site) [chemical binding]; other site
325240000575	Cytochrome c; Region: Cytochrom_C; cl11414
325240000576	sulfite oxidase; Provisional; Region: PLN00177
325240000577	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
325240000578	Moco binding site; other site
325240000579	metal coordination site [ion binding]; other site
325240000580	dimerization interface [polypeptide binding]; other site
325240000581	Cytochrome c; Region: Cytochrom_C; cl11414
325240000582	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
325240000583	HDOD domain; Region: HDOD; pfam08668
325240000584	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
325240000585	Zn2+ binding site [ion binding]; other site
325240000586	Mg2+ binding site [ion binding]; other site
325240000587	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
325240000588	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
325240000589	dimer interface [polypeptide binding]; other site
325240000590	motif 1; other site
325240000591	active site
325240000592	motif 2; other site
325240000593	motif 3; other site
325240000594	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
325240000595	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
325240000596	Amidohydrolase; Region: Amidohydro_5; pfam13594
325240000597	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
325240000598	active site
325240000599	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
325240000600	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
325240000601	MOSC domain; Region: MOSC; pfam03473
325240000602	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
325240000603	CPxP  motif; other site
325240000604	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
325240000605	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
325240000606	dimer interface [polypeptide binding]; other site
325240000607	active site
325240000608	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
325240000609	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
325240000610	substrate binding site [chemical binding]; other site
325240000611	oxyanion hole (OAH) forming residues; other site
325240000612	trimer interface [polypeptide binding]; other site
325240000613	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
325240000614	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
325240000615	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
325240000616	proline dipeptidase; Provisional; Region: PRK13607
325240000617	Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433
325240000618	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
325240000619	active site
325240000620	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
325240000621	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
325240000622	Cation transport protein; Region: TrkH; cl17365
325240000623	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
325240000624	Flavodoxin domain; Region: Flavodoxin_5; cl17428
325240000625	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
325240000626	dimerization interface [polypeptide binding]; other site
325240000627	putative DNA binding site [nucleotide binding]; other site
325240000628	putative Zn2+ binding site [ion binding]; other site
325240000629	Flavodoxin domain; Region: Flavodoxin_5; cl17428
325240000630	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
325240000631	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
325240000632	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
325240000633	TrkA-N domain; Region: TrkA_N; pfam02254
325240000634	TrkA-C domain; Region: TrkA_C; pfam02080
325240000635	TrkA-N domain; Region: TrkA_N; pfam02254
325240000636	TrkA-C domain; Region: TrkA_C; pfam02080
325240000637	16S rRNA methyltransferase B; Provisional; Region: PRK10901
325240000638	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
325240000639	putative RNA binding site [nucleotide binding]; other site
325240000640	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240000641	S-adenosylmethionine binding site [chemical binding]; other site
325240000642	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
325240000643	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
325240000644	putative active site [active]
325240000645	substrate binding site [chemical binding]; other site
325240000646	putative cosubstrate binding site; other site
325240000647	catalytic site [active]
325240000648	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
325240000649	substrate binding site [chemical binding]; other site
325240000650	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
325240000651	active site
325240000652	catalytic residues [active]
325240000653	metal binding site [ion binding]; metal-binding site
325240000654	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
325240000655	DNA protecting protein DprA; Region: dprA; TIGR00732
325240000656	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
325240000657	Protein of unknown function (DUF494); Region: DUF494; pfam04361
325240000658	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
325240000659	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
325240000660	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
325240000661	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
325240000662	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
325240000663	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
325240000664	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
325240000665	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
325240000666	apolar tunnel; other site
325240000667	heme binding site [chemical binding]; other site
325240000668	dimerization interface [polypeptide binding]; other site
325240000669	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
325240000670	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
325240000671	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
325240000672	shikimate binding site; other site
325240000673	NAD(P) binding site [chemical binding]; other site
325240000674	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
325240000675	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
325240000676	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
325240000677	trimer interface [polypeptide binding]; other site
325240000678	putative metal binding site [ion binding]; other site
325240000679	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240000680	PAS fold; Region: PAS_3; pfam08447
325240000681	putative active site [active]
325240000682	heme pocket [chemical binding]; other site
325240000683	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240000684	metal binding site [ion binding]; metal-binding site
325240000685	active site
325240000686	I-site; other site
325240000687	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240000688	lysophospholipase L2; Provisional; Region: PRK10749
325240000689	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
325240000690	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
325240000691	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
325240000692	adenosine deaminase; Provisional; Region: PRK09358
325240000693	active site
325240000694	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
325240000695	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
325240000696	FeS/SAM binding site; other site
325240000697	HemN C-terminal domain; Region: HemN_C; pfam06969
325240000698	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
325240000699	Der GTPase activator (YihI); Region: YihI; pfam04220
325240000700	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
325240000701	Methyltransferase domain; Region: Methyltransf_23; pfam13489
325240000702	Cytochrome c553 [Energy production and conversion]; Region: COG2863
325240000703	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
325240000704	Cytochrome c; Region: Cytochrom_C; cl11414
325240000705	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
325240000706	G1 box; other site
325240000707	GTP/Mg2+ binding site [chemical binding]; other site
325240000708	Switch I region; other site
325240000709	G2 box; other site
325240000710	G3 box; other site
325240000711	Switch II region; other site
325240000712	G4 box; other site
325240000713	G5 box; other site
325240000714	DNA polymerase I; Provisional; Region: PRK05755
325240000715	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
325240000716	active site
325240000717	metal binding site 1 [ion binding]; metal-binding site
325240000718	putative 5' ssDNA interaction site; other site
325240000719	metal binding site 3; metal-binding site
325240000720	metal binding site 2 [ion binding]; metal-binding site
325240000721	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
325240000722	putative DNA binding site [nucleotide binding]; other site
325240000723	putative metal binding site [ion binding]; other site
325240000724	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
325240000725	active site
325240000726	catalytic site [active]
325240000727	substrate binding site [chemical binding]; other site
325240000728	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
325240000729	active site
325240000730	DNA binding site [nucleotide binding]
325240000731	catalytic site [active]
325240000732	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
325240000733	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
325240000734	conserved cys residue [active]
325240000735	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
325240000736	rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239
325240000737	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
325240000738	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
325240000739	active site residue [active]
325240000740	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
325240000741	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
325240000742	NAD(P) binding site [chemical binding]; other site
325240000743	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
325240000744	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
325240000745	substrate-cofactor binding pocket; other site
325240000746	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240000747	catalytic residue [active]
325240000748	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
325240000749	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
325240000750	Bacterial transcriptional repressor; Region: TetR; pfam13972
325240000751	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
325240000752	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
325240000753	3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723
325240000754	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293
325240000755	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
325240000756	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
325240000757	putative active site [active]
325240000758	conserved hypothetical protein; Region: MJ1255; TIGR00661
325240000759	Beta-1,4-N-acetylgalactosaminyltransferase (CgtA); Region: CgtA; pfam06306
325240000760	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
325240000761	active site
325240000762	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
325240000763	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
325240000764	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
325240000765	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
325240000766	active site
325240000767	homodimer interface [polypeptide binding]; other site
325240000768	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
325240000769	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
325240000770	active site
325240000771	(T/H)XGH motif; other site
325240000772	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
325240000773	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
325240000774	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
325240000775	putative NAD(P) binding site [chemical binding]; other site
325240000776	active site
325240000777	putative substrate binding site [chemical binding]; other site
325240000778	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
325240000779	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
325240000780	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
325240000781	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
325240000782	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
325240000783	Ligand binding site; other site
325240000784	Putative Catalytic site; other site
325240000785	DXD motif; other site
325240000786	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
325240000787	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
325240000788	DNA binding site [nucleotide binding]
325240000789	catalytic residue [active]
325240000790	H2TH interface [polypeptide binding]; other site
325240000791	putative catalytic residues [active]
325240000792	turnover-facilitating residue; other site
325240000793	intercalation triad [nucleotide binding]; other site
325240000794	8OG recognition residue [nucleotide binding]; other site
325240000795	putative reading head residues; other site
325240000796	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
325240000797	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
325240000798	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
325240000799	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
325240000800	FeS/SAM binding site; other site
325240000801	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
325240000802	putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional; Region: PRK14491
325240000803	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
325240000804	Walker A motif; other site
325240000805	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
325240000806	dimer interface [polypeptide binding]; other site
325240000807	putative functional site; other site
325240000808	putative MPT binding site; other site
325240000809	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
325240000810	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
325240000811	GTP binding site; other site
325240000812	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
325240000813	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240000814	Walker A/P-loop; other site
325240000815	ATP binding site [chemical binding]; other site
325240000816	Q-loop/lid; other site
325240000817	ABC transporter signature motif; other site
325240000818	Walker B; other site
325240000819	D-loop; other site
325240000820	H-loop/switch region; other site
325240000821	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
325240000822	dimer interface [polypeptide binding]; other site
325240000823	conserved gate region; other site
325240000824	putative PBP binding loops; other site
325240000825	ABC-ATPase subunit interface; other site
325240000826	PBP superfamily domain; Region: PBP_like_2; pfam12849
325240000827	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
325240000828	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
325240000829	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240000830	active site
325240000831	phosphorylation site [posttranslational modification]
325240000832	intermolecular recognition site; other site
325240000833	dimerization interface [polypeptide binding]; other site
325240000834	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240000835	Walker A motif; other site
325240000836	ATP binding site [chemical binding]; other site
325240000837	Walker B motif; other site
325240000838	arginine finger; other site
325240000839	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
325240000840	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
325240000841	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240000842	dimer interface [polypeptide binding]; other site
325240000843	phosphorylation site [posttranslational modification]
325240000844	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240000845	ATP binding site [chemical binding]; other site
325240000846	G-X-G motif; other site
325240000847	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240000848	Coenzyme A binding pocket [chemical binding]; other site
325240000849	hypothetical protein; Provisional; Region: PRK11212
325240000850	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
325240000851	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
325240000852	chorismate binding enzyme; Region: Chorismate_bind; cl10555
325240000853	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240000854	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240000855	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
325240000856	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
325240000857	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
325240000858	Walker A/P-loop; other site
325240000859	ATP binding site [chemical binding]; other site
325240000860	Q-loop/lid; other site
325240000861	ABC transporter signature motif; other site
325240000862	Walker B; other site
325240000863	D-loop; other site
325240000864	H-loop/switch region; other site
325240000865	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240000866	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
325240000867	Walker A/P-loop; other site
325240000868	ATP binding site [chemical binding]; other site
325240000869	Q-loop/lid; other site
325240000870	ABC transporter signature motif; other site
325240000871	Walker B; other site
325240000872	D-loop; other site
325240000873	H-loop/switch region; other site
325240000874	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
325240000875	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
325240000876	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
325240000877	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
325240000878	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
325240000879	Zn2+ binding site [ion binding]; other site
325240000880	Mg2+ binding site [ion binding]; other site
325240000881	Paraquat-inducible protein A; Region: PqiA; pfam04403
325240000882	Protein of unknown function (DUF3240); Region: DUF3240; pfam11582
325240000883	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
325240000884	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240000885	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
325240000886	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
325240000887	DNA binding residues [nucleotide binding]
325240000888	dimerization interface [polypeptide binding]; other site
325240000889	Predicted membrane protein [Function unknown]; Region: COG2855
325240000890	malate synthase; Provisional; Region: PRK08951
325240000891	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
325240000892	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
325240000893	non-specific DNA binding site [nucleotide binding]; other site
325240000894	salt bridge; other site
325240000895	sequence-specific DNA binding site [nucleotide binding]; other site
325240000896	Protein of unknown function (DUF3612); Region: DUF3612; pfam12268
325240000897	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
325240000898	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
325240000899	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
325240000900	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
325240000901	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
325240000902	Protein export membrane protein; Region: SecD_SecF; cl14618
325240000903	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
325240000904	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
325240000905	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240000906	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
325240000907	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
325240000908	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
325240000909	N-terminal plug; other site
325240000910	ligand-binding site [chemical binding]; other site
325240000911	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
325240000912	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
325240000913	putative catalytic cysteine [active]
325240000914	gamma-glutamyl kinase; Provisional; Region: PRK13402
325240000915	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
325240000916	nucleotide binding site [chemical binding]; other site
325240000917	homotetrameric interface [polypeptide binding]; other site
325240000918	putative phosphate binding site [ion binding]; other site
325240000919	putative allosteric binding site; other site
325240000920	PUA domain; Region: PUA; cl00607
325240000921	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
325240000922	Na binding site [ion binding]; other site
325240000923	Fusaric acid resistance protein family; Region: FUSC; pfam04632
325240000924	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
325240000925	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
325240000926	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
325240000927	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240000928	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
325240000929	glutathione reductase; Validated; Region: PRK06116
325240000930	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
325240000931	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
325240000932	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
325240000933	oligopeptidase A; Provisional; Region: PRK10911
325240000934	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
325240000935	active site
325240000936	Zn binding site [ion binding]; other site
325240000937	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
325240000938	active site
325240000939	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
325240000940	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
325240000941	C-terminal domain interface [polypeptide binding]; other site
325240000942	GSH binding site (G-site) [chemical binding]; other site
325240000943	dimer interface [polypeptide binding]; other site
325240000944	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
325240000945	N-terminal domain interface [polypeptide binding]; other site
325240000946	dimer interface [polypeptide binding]; other site
325240000947	substrate binding pocket (H-site) [chemical binding]; other site
325240000948	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
325240000949	conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001
325240000950	Helix-turn-helix domain; Region: HTH_28; pfam13518
325240000951	Winged helix-turn helix; Region: HTH_29; pfam13551
325240000952	Homeodomain-like domain; Region: HTH_32; pfam13565
325240000953	Integrase core domain; Region: rve; pfam00665
325240000954	DDE domain; Region: DDE_Tnp_IS240; pfam13610
325240000955	Integrase core domain; Region: rve_3; pfam13683
325240000956	Transposase; Region: HTH_Tnp_1; pfam01527
325240000957	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240000958	putative transposase OrfB; Reviewed; Region: PHA02517
325240000959	HTH-like domain; Region: HTH_21; pfam13276
325240000960	Integrase core domain; Region: rve; pfam00665
325240000961	Integrase core domain; Region: rve_2; pfam13333
325240000962	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
325240000963	active site
325240000964	catalytic triad [active]
325240000965	oxyanion hole [active]
325240000966	Rho-activating domain of cytotoxic necrotizing factor; Region: CNF1; pfam05785
325240000967	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
325240000968	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
325240000969	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
325240000970	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
325240000971	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
325240000972	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
325240000973	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
325240000974	RNA binding site [nucleotide binding]; other site
325240000975	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
325240000976	Sulfatase; Region: Sulfatase; pfam00884
325240000977	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
325240000978	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
325240000979	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
325240000980	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
325240000981	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
325240000982	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
325240000983	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
325240000984	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
325240000985	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
325240000986	Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973
325240000987	putative active site [active]
325240000988	putative metal binding site [ion binding]; other site
325240000989	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
325240000990	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
325240000991	Cu(I) binding site [ion binding]; other site
325240000992	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
325240000993	UbiA prenyltransferase family; Region: UbiA; pfam01040
325240000994	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
325240000995	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
325240000996	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
325240000997	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
325240000998	Subunit III/VIIa interface [polypeptide binding]; other site
325240000999	Phospholipid binding site [chemical binding]; other site
325240001000	Subunit I/III interface [polypeptide binding]; other site
325240001001	Subunit III/VIb interface [polypeptide binding]; other site
325240001002	Subunit III/VIa interface; other site
325240001003	Subunit III/Vb interface [polypeptide binding]; other site
325240001004	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
325240001005	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
325240001006	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
325240001007	Subunit I/III interface [polypeptide binding]; other site
325240001008	D-pathway; other site
325240001009	Subunit I/VIIc interface [polypeptide binding]; other site
325240001010	Subunit I/IV interface [polypeptide binding]; other site
325240001011	Subunit I/II interface [polypeptide binding]; other site
325240001012	Low-spin heme (heme a) binding site [chemical binding]; other site
325240001013	Subunit I/VIIa interface [polypeptide binding]; other site
325240001014	Subunit I/VIa interface [polypeptide binding]; other site
325240001015	Dimer interface; other site
325240001016	Putative water exit pathway; other site
325240001017	Binuclear center (heme a3/CuB) [ion binding]; other site
325240001018	K-pathway; other site
325240001019	Subunit I/Vb interface [polypeptide binding]; other site
325240001020	Putative proton exit pathway; other site
325240001021	Subunit I/VIb interface; other site
325240001022	Subunit I/VIc interface [polypeptide binding]; other site
325240001023	Electron transfer pathway; other site
325240001024	Subunit I/VIIIb interface [polypeptide binding]; other site
325240001025	Subunit I/VIIb interface [polypeptide binding]; other site
325240001026	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
325240001027	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00038
325240001028	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
325240001029	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
325240001030	Cytochrome c; Region: Cytochrom_C; pfam00034
325240001031	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
325240001032	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
325240001033	Cell division inhibitor SulA; Region: SulA; cl01880
325240001034	LexA repressor; Validated; Region: PRK00215
325240001035	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
325240001036	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
325240001037	Catalytic site [active]
325240001038	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
325240001039	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
325240001040	putative acyl-acceptor binding pocket; other site
325240001041	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
325240001042	aromatic amino acid transport protein; Region: araaP; TIGR00837
325240001043	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
325240001044	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
325240001045	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
325240001046	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240001047	dimerization interface [polypeptide binding]; other site
325240001048	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
325240001049	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240001050	dimer interface [polypeptide binding]; other site
325240001051	putative CheW interface [polypeptide binding]; other site
325240001052	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
325240001053	B1 nucleotide binding pocket [chemical binding]; other site
325240001054	B2 nucleotide binding pocket [chemical binding]; other site
325240001055	CAS motifs; other site
325240001056	active site
325240001057	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
325240001058	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
325240001059	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240001060	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437
325240001061	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
325240001062	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
325240001063	Protein of unknown function (DUF1145); Region: DUF1145; pfam06611
325240001064	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
325240001065	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240001066	S-adenosylmethionine binding site [chemical binding]; other site
325240001067	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
325240001068	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
325240001069	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
325240001070	P loop; other site
325240001071	GTP binding site [chemical binding]; other site
325240001072	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
325240001073	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240001074	Walker A/P-loop; other site
325240001075	ATP binding site [chemical binding]; other site
325240001076	Q-loop/lid; other site
325240001077	ABC transporter signature motif; other site
325240001078	Walker B; other site
325240001079	D-loop; other site
325240001080	H-loop/switch region; other site
325240001081	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
325240001082	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
325240001083	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
325240001084	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
325240001085	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
325240001086	DNA binding residues [nucleotide binding]
325240001087	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
325240001088	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
325240001089	acyl-activating enzyme (AAE) consensus motif; other site
325240001090	putative AMP binding site [chemical binding]; other site
325240001091	putative active site [active]
325240001092	putative CoA binding site [chemical binding]; other site
325240001093	O-succinylbenzoate synthase; Provisional; Region: PRK05105
325240001094	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
325240001095	active site
325240001096	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
325240001097	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
325240001098	nucleophilic elbow; other site
325240001099	catalytic triad; other site
325240001100	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
325240001101	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
325240001102	dimer interface [polypeptide binding]; other site
325240001103	tetramer interface [polypeptide binding]; other site
325240001104	PYR/PP interface [polypeptide binding]; other site
325240001105	TPP binding site [chemical binding]; other site
325240001106	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
325240001107	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
325240001108	TPP-binding site; other site
325240001109	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240001110	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240001111	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
325240001112	dimerization interface [polypeptide binding]; other site
325240001113	radical SAM peptide maturase, FibroRumin system; Region: rSAM_FibroRumin; TIGR04136
325240001114	cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146
325240001115	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
325240001116	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
325240001117	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
325240001118	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
325240001119	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
325240001120	dimerization interface [polypeptide binding]; other site
325240001121	putative Zn2+ binding site [ion binding]; other site
325240001122	putative DNA binding site [nucleotide binding]; other site
325240001123	AsnC family; Region: AsnC_trans_reg; pfam01037
325240001124	Spore germination protein; Region: Spore_permease; cl17796
325240001125	putative transporter; Provisional; Region: PRK11021
325240001126	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
325240001127	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
325240001128	HDOD domain; Region: HDOD; pfam08668
325240001129	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
325240001130	putative metal binding site [ion binding]; other site
325240001131	Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075
325240001132	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
325240001133	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
325240001134	Sel1-like repeats; Region: SEL1; smart00671
325240001135	Cache domain; Region: Cache_1; pfam02743
325240001136	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240001137	dimerization interface [polypeptide binding]; other site
325240001138	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240001139	dimer interface [polypeptide binding]; other site
325240001140	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
325240001141	putative CheW interface [polypeptide binding]; other site
325240001142	Cache domain; Region: Cache_1; pfam02743
325240001143	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240001144	dimerization interface [polypeptide binding]; other site
325240001145	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240001146	dimer interface [polypeptide binding]; other site
325240001147	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
325240001148	putative CheW interface [polypeptide binding]; other site
325240001149	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
325240001150	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240001151	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
325240001152	substrate binding pocket [chemical binding]; other site
325240001153	dimerization interface [polypeptide binding]; other site
325240001154	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240001155	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
325240001156	putative substrate translocation pore; other site
325240001157	DTW domain; Region: DTW; cl01221
325240001158	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240001159	PAS domain; Region: PAS_9; pfam13426
325240001160	putative active site [active]
325240001161	heme pocket [chemical binding]; other site
325240001162	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240001163	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240001164	metal binding site [ion binding]; metal-binding site
325240001165	active site
325240001166	I-site; other site
325240001167	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240001168	Methyltransferase domain; Region: Methyltransf_23; pfam13489
325240001169	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240001170	S-adenosylmethionine binding site [chemical binding]; other site
325240001171	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
325240001172	NIPSNAP; Region: NIPSNAP; pfam07978
325240001173	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
325240001174	dimerization interface [polypeptide binding]; other site
325240001175	putative DNA binding site [nucleotide binding]; other site
325240001176	putative Zn2+ binding site [ion binding]; other site
325240001177	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
325240001178	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667
325240001179	metal binding site [ion binding]; metal-binding site
325240001180	putative dimer interface [polypeptide binding]; other site
325240001181	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
325240001182	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
325240001183	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
325240001184	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
325240001185	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
325240001186	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
325240001187	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
325240001188	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
325240001189	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
325240001190	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
325240001191	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
325240001192	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
325240001193	substrate binding pocket [chemical binding]; other site
325240001194	membrane-bound complex binding site; other site
325240001195	hinge residues; other site
325240001196	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
325240001197	EamA-like transporter family; Region: EamA; pfam00892
325240001198	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
325240001199	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240001200	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
325240001201	substrate binding pocket [chemical binding]; other site
325240001202	dimerization interface [polypeptide binding]; other site
325240001203	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
325240001204	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
325240001205	active site
325240001206	nucleophile elbow; other site
325240001207	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240001208	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240001209	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
325240001210	putative effector binding pocket; other site
325240001211	dimerization interface [polypeptide binding]; other site
325240001212	enterobactin receptor protein; Provisional; Region: PRK13483
325240001213	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
325240001214	N-terminal plug; other site
325240001215	ligand-binding site [chemical binding]; other site
325240001216	Sec63 Brl domain; Region: Sec63; pfam02889
325240001217	coproporphyrinogen III oxidase; Provisional; Region: PRK08629
325240001218	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
325240001219	FeS/SAM binding site; other site
325240001220	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
325240001221	Sodium Bile acid symporter family; Region: SBF; pfam01758
325240001222	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
325240001223	Sel1-like repeats; Region: SEL1; smart00671
325240001224	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
325240001225	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
325240001226	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
325240001227	heme exporter protein CcmC; Region: ccmC; TIGR01191
325240001228	CcmB protein; Region: CcmB; pfam03379
325240001229	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
325240001230	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240001231	Walker A/P-loop; other site
325240001232	ATP binding site [chemical binding]; other site
325240001233	Q-loop/lid; other site
325240001234	ABC transporter signature motif; other site
325240001235	Walker B; other site
325240001236	D-loop; other site
325240001237	H-loop/switch region; other site
325240001238	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
325240001239	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
325240001240	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
325240001241	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240001242	TPR motif; other site
325240001243	binding surface
325240001244	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
325240001245	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
325240001246	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
325240001247	catalytic residues [active]
325240001248	central insert; other site
325240001249	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
325240001250	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
325240001251	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
325240001252	catalytic residues [active]
325240001253	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
325240001254	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
325240001255	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240001256	Coenzyme A binding pocket [chemical binding]; other site
325240001257	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
325240001258	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
325240001259	dimer interface [polypeptide binding]; other site
325240001260	phosphorylation site [posttranslational modification]
325240001261	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240001262	ATP binding site [chemical binding]; other site
325240001263	Mg2+ binding site [ion binding]; other site
325240001264	G-X-G motif; other site
325240001265	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
325240001266	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240001267	active site
325240001268	phosphorylation site [posttranslational modification]
325240001269	intermolecular recognition site; other site
325240001270	dimerization interface [polypeptide binding]; other site
325240001271	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
325240001272	DNA binding site [nucleotide binding]
325240001273	Predicted membrane protein [Function unknown]; Region: COG3212
325240001274	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
325240001275	Dihaem cytochrome c; Region: DHC; pfam09626
325240001276	Domain of unknown function (DUF1924); Region: DUF1924; pfam09086
325240001277	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
325240001278	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
325240001279	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240001280	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240001281	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
325240001282	putative effector binding pocket; other site
325240001283	putative dimerization interface [polypeptide binding]; other site
325240001284	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
325240001285	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
325240001286	NAD(P) binding site [chemical binding]; other site
325240001287	active site
325240001288	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
325240001289	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
325240001290	NAD(P) binding site [chemical binding]; other site
325240001291	catalytic residues [active]
325240001292	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
325240001293	GAF domain; Region: GAF; pfam01590
325240001294	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240001295	Walker A motif; other site
325240001296	ATP binding site [chemical binding]; other site
325240001297	Walker B motif; other site
325240001298	arginine finger; other site
325240001299	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
325240001300	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
325240001301	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
325240001302	NADP binding site [chemical binding]; other site
325240001303	dimer interface [polypeptide binding]; other site
325240001304	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
325240001305	Winged helix-turn helix; Region: HTH_29; pfam13551
325240001306	Homeodomain-like domain; Region: HTH_32; pfam13565
325240001307	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
325240001308	Integrase core domain; Region: rve; pfam00665
325240001309	Integrase core domain; Region: rve_3; pfam13683
325240001310	Transposase; Region: HTH_Tnp_1; cl17663
325240001311	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
325240001312	L-aspartate oxidase; Provisional; Region: PRK06175
325240001313	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
325240001314	heme-binding residues [chemical binding]; other site
325240001315	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240001316	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240001317	LysR substrate binding domain; Region: LysR_substrate; pfam03466
325240001318	dimerization interface [polypeptide binding]; other site
325240001319	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
325240001320	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
325240001321	two-component sensor protein; Provisional; Region: cpxA; PRK09470
325240001322	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240001323	dimerization interface [polypeptide binding]; other site
325240001324	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240001325	dimer interface [polypeptide binding]; other site
325240001326	phosphorylation site [posttranslational modification]
325240001327	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240001328	ATP binding site [chemical binding]; other site
325240001329	Mg2+ binding site [ion binding]; other site
325240001330	G-X-G motif; other site
325240001331	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240001332	active site
325240001333	phosphorylation site [posttranslational modification]
325240001334	intermolecular recognition site; other site
325240001335	dimerization interface [polypeptide binding]; other site
325240001336	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
325240001337	DNA binding site [nucleotide binding]
325240001338	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
325240001339	dimer interface [polypeptide binding]; other site
325240001340	Cation efflux family; Region: Cation_efflux; cl00316
325240001341	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
325240001342	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
325240001343	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240001344	active site
325240001345	phosphorylation site [posttranslational modification]
325240001346	intermolecular recognition site; other site
325240001347	dimerization interface [polypeptide binding]; other site
325240001348	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240001349	Walker A motif; other site
325240001350	ATP binding site [chemical binding]; other site
325240001351	Walker B motif; other site
325240001352	arginine finger; other site
325240001353	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
325240001354	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
325240001355	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240001356	dimer interface [polypeptide binding]; other site
325240001357	phosphorylation site [posttranslational modification]
325240001358	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240001359	ATP binding site [chemical binding]; other site
325240001360	Mg2+ binding site [ion binding]; other site
325240001361	G-X-G motif; other site
325240001362	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
325240001363	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
325240001364	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
325240001365	putative C-terminal domain interface [polypeptide binding]; other site
325240001366	putative GSH binding site (G-site) [chemical binding]; other site
325240001367	putative dimer interface [polypeptide binding]; other site
325240001368	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
325240001369	N-terminal domain interface [polypeptide binding]; other site
325240001370	dimer interface [polypeptide binding]; other site
325240001371	substrate binding pocket (H-site) [chemical binding]; other site
325240001372	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
325240001373	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
325240001374	potential catalytic triad [active]
325240001375	conserved cys residue [active]
325240001376	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
325240001377	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
325240001378	dimer interface [polypeptide binding]; other site
325240001379	active site
325240001380	metal binding site [ion binding]; metal-binding site
325240001381	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
325240001382	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
325240001383	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
325240001384	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
325240001385	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240001386	dimer interface [polypeptide binding]; other site
325240001387	putative CheW interface [polypeptide binding]; other site
325240001388	5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344
325240001389	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
325240001390	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240001391	S-adenosylmethionine binding site [chemical binding]; other site
325240001392	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
325240001393	substrate binding site [chemical binding]; other site
325240001394	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
325240001395	ATP binding site [chemical binding]; other site
325240001396	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240001397	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240001398	metal binding site [ion binding]; metal-binding site
325240001399	active site
325240001400	I-site; other site
325240001401	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
325240001402	MOSC domain; Region: MOSC; pfam03473
325240001403	3-alpha domain; Region: 3-alpha; pfam03475
325240001404	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
325240001405	Cache domain; Region: Cache_1; pfam02743
325240001406	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240001407	dimerization interface [polypeptide binding]; other site
325240001408	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
325240001409	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240001410	dimer interface [polypeptide binding]; other site
325240001411	putative CheW interface [polypeptide binding]; other site
325240001412	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
325240001413	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
325240001414	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
325240001415	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
325240001416	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
325240001417	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
325240001418	FeS/SAM binding site; other site
325240001419	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
325240001420	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
325240001421	trimer interface [polypeptide binding]; other site
325240001422	dimer interface [polypeptide binding]; other site
325240001423	putative active site [active]
325240001424	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
325240001425	MoaE interaction surface [polypeptide binding]; other site
325240001426	MoeB interaction surface [polypeptide binding]; other site
325240001427	thiocarboxylated glycine; other site
325240001428	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
325240001429	MoaE homodimer interface [polypeptide binding]; other site
325240001430	MoaD interaction [polypeptide binding]; other site
325240001431	active site residues [active]
325240001432	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
325240001433	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
325240001434	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
325240001435	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
325240001436	dimer interface [polypeptide binding]; other site
325240001437	conserved gate region; other site
325240001438	putative PBP binding loops; other site
325240001439	ABC-ATPase subunit interface; other site
325240001440	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240001441	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
325240001442	Walker A/P-loop; other site
325240001443	ATP binding site [chemical binding]; other site
325240001444	Q-loop/lid; other site
325240001445	ABC transporter signature motif; other site
325240001446	Walker B; other site
325240001447	D-loop; other site
325240001448	H-loop/switch region; other site
325240001449	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
325240001450	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240001451	active site
325240001452	phosphorylation site [posttranslational modification]
325240001453	intermolecular recognition site; other site
325240001454	dimerization interface [polypeptide binding]; other site
325240001455	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
325240001456	DNA binding site [nucleotide binding]
325240001457	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
325240001458	HAMP domain; Region: HAMP; pfam00672
325240001459	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240001460	dimer interface [polypeptide binding]; other site
325240001461	phosphorylation site [posttranslational modification]
325240001462	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240001463	ATP binding site [chemical binding]; other site
325240001464	Mg2+ binding site [ion binding]; other site
325240001465	G-X-G motif; other site
325240001466	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
325240001467	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
325240001468	active site
325240001469	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240001470	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240001471	metal binding site [ion binding]; metal-binding site
325240001472	active site
325240001473	I-site; other site
325240001474	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
325240001475	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
325240001476	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
325240001477	N-terminal plug; other site
325240001478	ligand-binding site [chemical binding]; other site
325240001479	Protein of unknown function (DUF2986); Region: DUF2986; pfam11661
325240001480	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
325240001481	Peptidase family M23; Region: Peptidase_M23; pfam01551
325240001482	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
325240001483	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
325240001484	Domain of unknown function (DUF1864); Region: DUF1864; pfam08933
325240001485	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
325240001486	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
325240001487	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
325240001488	catalytic residue [active]
325240001489	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
325240001490	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
325240001491	glutamine synthetase; Provisional; Region: glnA; PRK09469
325240001492	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
325240001493	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
325240001494	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
325240001495	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
325240001496	G1 box; other site
325240001497	putative GEF interaction site [polypeptide binding]; other site
325240001498	GTP/Mg2+ binding site [chemical binding]; other site
325240001499	Switch I region; other site
325240001500	G2 box; other site
325240001501	G3 box; other site
325240001502	Switch II region; other site
325240001503	G4 box; other site
325240001504	G5 box; other site
325240001505	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
325240001506	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
325240001507	SnoaL-like domain; Region: SnoaL_3; pfam13474
325240001508	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240001509	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240001510	metal binding site [ion binding]; metal-binding site
325240001511	active site
325240001512	I-site; other site
325240001513	Sulfatase; Region: Sulfatase; cl17466
325240001514	4Fe-4S binding domain; Region: Fer4_5; pfam12801
325240001515	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
325240001516	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
325240001517	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
325240001518	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
325240001519	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
325240001520	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
325240001521	homodimer interface [polypeptide binding]; other site
325240001522	substrate-cofactor binding pocket; other site
325240001523	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240001524	catalytic residue [active]
325240001525	Protein of unknown function (DUF2959); Region: DUF2959; pfam11172
325240001526	hypothetical protein; Reviewed; Region: PRK01637
325240001527	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
325240001528	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
325240001529	putative active site [active]
325240001530	dimerization interface [polypeptide binding]; other site
325240001531	putative tRNAtyr binding site [nucleotide binding]; other site
325240001532	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
325240001533	CoenzymeA binding site [chemical binding]; other site
325240001534	subunit interaction site [polypeptide binding]; other site
325240001535	PHB binding site; other site
325240001536	azoreductase; Reviewed; Region: PRK00170
325240001537	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
325240001538	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
325240001539	active site residue [active]
325240001540	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
325240001541	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
325240001542	non-specific DNA binding site [nucleotide binding]; other site
325240001543	salt bridge; other site
325240001544	sequence-specific DNA binding site [nucleotide binding]; other site
325240001545	Cupin domain; Region: Cupin_2; pfam07883
325240001546	Benzoate membrane transport protein; Region: BenE; pfam03594
325240001547	benzoate transporter; Region: benE; TIGR00843
325240001548	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
325240001549	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240001550	Coenzyme A binding pocket [chemical binding]; other site
325240001551	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
325240001552	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
325240001553	dimer interface [polypeptide binding]; other site
325240001554	active site
325240001555	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
325240001556	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
325240001557	NAD(P) binding site [chemical binding]; other site
325240001558	homotetramer interface [polypeptide binding]; other site
325240001559	homodimer interface [polypeptide binding]; other site
325240001560	active site
325240001561	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
325240001562	putative active site 1 [active]
325240001563	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
325240001564	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
325240001565	dimer interface [polypeptide binding]; other site
325240001566	active site
325240001567	Protein of unknown function (DUF3261); Region: DUF3261; pfam11659
325240001568	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
325240001569	Predicted exporter [General function prediction only]; Region: COG4258
325240001570	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
325240001571	active site
325240001572	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
325240001573	active sites [active]
325240001574	tetramer interface [polypeptide binding]; other site
325240001575	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
325240001576	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
325240001577	Ligand binding site; other site
325240001578	Putative Catalytic site; other site
325240001579	DXD motif; other site
325240001580	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
325240001581	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
325240001582	putative acyl-acceptor binding pocket; other site
325240001583	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
325240001584	active site 2 [active]
325240001585	dimer interface [polypeptide binding]; other site
325240001586	active site 1 [active]
325240001587	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
325240001588	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
325240001589	acyl-activating enzyme (AAE) consensus motif; other site
325240001590	AMP binding site [chemical binding]; other site
325240001591	active site
325240001592	CoA binding site [chemical binding]; other site
325240001593	Predicted membrane protein [Function unknown]; Region: COG4648
325240001594	acyl carrier protein; Provisional; Region: PRK05350
325240001595	Phosphopantetheine attachment site; Region: PP-binding; cl09936
325240001596	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
325240001597	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
325240001598	putative acyl-acceptor binding pocket; other site
325240001599	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
325240001600	Protein of unknown function (DUF3014); Region: DUF3014; pfam11219
325240001601	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
325240001602	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
325240001603	generic binding surface II; other site
325240001604	ssDNA binding site; other site
325240001605	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
325240001606	ATP binding site [chemical binding]; other site
325240001607	putative Mg++ binding site [ion binding]; other site
325240001608	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240001609	nucleotide binding region [chemical binding]; other site
325240001610	ATP-binding site [chemical binding]; other site
325240001611	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
325240001612	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240001613	active site
325240001614	phosphorylation site [posttranslational modification]
325240001615	intermolecular recognition site; other site
325240001616	dimerization interface [polypeptide binding]; other site
325240001617	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
325240001618	DNA binding residues [nucleotide binding]
325240001619	dimerization interface [polypeptide binding]; other site
325240001620	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
325240001621	Histidine kinase; Region: HisKA_3; pfam07730
325240001622	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240001623	ATP binding site [chemical binding]; other site
325240001624	Mg2+ binding site [ion binding]; other site
325240001625	G-X-G motif; other site
325240001626	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
325240001627	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
325240001628	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
325240001629	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
325240001630	Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932
325240001631	acyl-activating enzyme (AAE) consensus motif; other site
325240001632	putative AMP binding site [chemical binding]; other site
325240001633	putative active site [active]
325240001634	putative CoA binding site [chemical binding]; other site
325240001635	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
325240001636	homotrimer interaction site [polypeptide binding]; other site
325240001637	putative active site [active]
325240001638	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
325240001639	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
325240001640	Zn2+ binding site [ion binding]; other site
325240001641	Mg2+ binding site [ion binding]; other site
325240001642	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
325240001643	synthetase active site [active]
325240001644	NTP binding site [chemical binding]; other site
325240001645	metal binding site [ion binding]; metal-binding site
325240001646	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
325240001647	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
325240001648	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
325240001649	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
325240001650	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
325240001651	catalytic site [active]
325240001652	G-X2-G-X-G-K; other site
325240001653	ribonuclease E; Reviewed; Region: rne; PRK10811
325240001654	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
325240001655	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
325240001656	active site
325240001657	Phosphotransferase enzyme family; Region: APH; pfam01636
325240001658	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
325240001659	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240001660	putative substrate translocation pore; other site
325240001661	Major Facilitator Superfamily; Region: MFS_1; pfam07690
325240001662	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
325240001663	Fic family protein [Function unknown]; Region: COG3177
325240001664	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
325240001665	Fic/DOC family; Region: Fic; pfam02661
325240001666	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203
325240001667	PLD-like domain; Region: PLDc_2; pfam13091
325240001668	putative homodimer interface [polypeptide binding]; other site
325240001669	putative active site [active]
325240001670	catalytic site [active]
325240001671	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
325240001672	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
325240001673	ATP binding site [chemical binding]; other site
325240001674	putative Mg++ binding site [ion binding]; other site
325240001675	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240001676	nucleotide binding region [chemical binding]; other site
325240001677	ATP-binding site [chemical binding]; other site
325240001678	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
325240001679	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240001680	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240001681	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
325240001682	putative effector binding pocket; other site
325240001683	dimerization interface [polypeptide binding]; other site
325240001684	dUMP phosphatase; Provisional; Region: PRK09449
325240001685	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
325240001686	motif II; other site
325240001687	ERCC4 domain; Region: ERCC4; smart00891
325240001688	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
325240001689	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
325240001690	non-specific DNA binding site [nucleotide binding]; other site
325240001691	salt bridge; other site
325240001692	sequence-specific DNA binding site [nucleotide binding]; other site
325240001693	hypothetical protein; Provisional; Region: PRK11820
325240001694	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
325240001695	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
325240001696	ribonuclease PH; Reviewed; Region: rph; PRK00173
325240001697	Ribonuclease PH; Region: RNase_PH_bact; cd11362
325240001698	hexamer interface [polypeptide binding]; other site
325240001699	active site
325240001700	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
325240001701	active site
325240001702	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
325240001703	GTP cyclohydrolase I; Provisional; Region: PLN03044
325240001704	active site
325240001705	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
325240001706	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
325240001707	division inhibitor protein; Provisional; Region: slmA; PRK09480
325240001708	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
325240001709	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
325240001710	trimer interface [polypeptide binding]; other site
325240001711	active site
325240001712	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
325240001713	Flavoprotein; Region: Flavoprotein; pfam02441
325240001714	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
325240001715	hypothetical protein; Reviewed; Region: PRK00024
325240001716	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
325240001717	MPN+ (JAMM) motif; other site
325240001718	Zinc-binding site [ion binding]; other site
325240001719	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
325240001720	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
325240001721	N-acetylglutamate synthase; Validated; Region: PRK05279
325240001722	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
325240001723	putative feedback inhibition sensing region; other site
325240001724	putative nucleotide binding site [chemical binding]; other site
325240001725	putative substrate binding site [chemical binding]; other site
325240001726	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240001727	Coenzyme A binding pocket [chemical binding]; other site
325240001728	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
325240001729	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
325240001730	CoenzymeA binding site [chemical binding]; other site
325240001731	subunit interaction site [polypeptide binding]; other site
325240001732	PHB binding site; other site
325240001733	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
325240001734	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
325240001735	ATP binding site [chemical binding]; other site
325240001736	putative Mg++ binding site [ion binding]; other site
325240001737	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240001738	nucleotide binding region [chemical binding]; other site
325240001739	ATP-binding site [chemical binding]; other site
325240001740	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
325240001741	HRDC domain; Region: HRDC; pfam00570
325240001742	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240001743	I-site; other site
325240001744	active site
325240001745	metal binding site [ion binding]; metal-binding site
325240001746	2-isopropylmalate synthase; Validated; Region: PRK00915
325240001747	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
325240001748	active site
325240001749	catalytic residues [active]
325240001750	metal binding site [ion binding]; metal-binding site
325240001751	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
325240001752	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
325240001753	tartrate dehydrogenase; Region: TTC; TIGR02089
325240001754	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
325240001755	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
325240001756	substrate binding site [chemical binding]; other site
325240001757	ligand binding site [chemical binding]; other site
325240001758	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
325240001759	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
325240001760	substrate binding site [chemical binding]; other site
325240001761	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
325240001762	glycerol kinase; Provisional; Region: glpK; PRK00047
325240001763	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
325240001764	N- and C-terminal domain interface [polypeptide binding]; other site
325240001765	active site
325240001766	MgATP binding site [chemical binding]; other site
325240001767	catalytic site [active]
325240001768	metal binding site [ion binding]; metal-binding site
325240001769	glycerol binding site [chemical binding]; other site
325240001770	homotetramer interface [polypeptide binding]; other site
325240001771	homodimer interface [polypeptide binding]; other site
325240001772	FBP binding site [chemical binding]; other site
325240001773	protein IIAGlc interface [polypeptide binding]; other site
325240001774	cell division protein MraZ; Reviewed; Region: PRK00326
325240001775	MraZ protein; Region: MraZ; pfam02381
325240001776	MraZ protein; Region: MraZ; pfam02381
325240001777	MraW methylase family; Region: Methyltransf_5; pfam01795
325240001778	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
325240001779	Cell division protein FtsL; Region: FtsL; pfam04999
325240001780	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
325240001781	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
325240001782	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
325240001783	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
325240001784	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
325240001785	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
325240001786	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
325240001787	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
325240001788	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
325240001789	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
325240001790	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
325240001791	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
325240001792	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
325240001793	Mg++ binding site [ion binding]; other site
325240001794	putative catalytic motif [active]
325240001795	putative substrate binding site [chemical binding]; other site
325240001796	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
325240001797	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
325240001798	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
325240001799	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
325240001800	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
325240001801	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
325240001802	active site
325240001803	homodimer interface [polypeptide binding]; other site
325240001804	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
325240001805	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
325240001806	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
325240001807	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
325240001808	cell division protein FtsQ; Provisional; Region: PRK10775
325240001809	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
325240001810	Cell division protein FtsQ; Region: FtsQ; pfam03799
325240001811	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
325240001812	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
325240001813	nucleotide binding site [chemical binding]; other site
325240001814	Cell division protein FtsA; Region: FtsA; pfam14450
325240001815	cell division protein FtsZ; Validated; Region: PRK09330
325240001816	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
325240001817	nucleotide binding site [chemical binding]; other site
325240001818	SulA interaction site; other site
325240001819	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
325240001820	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
325240001821	Protein of unknown function (DUF721); Region: DUF721; cl02324
325240001822	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
325240001823	Peptidase family M23; Region: Peptidase_M23; pfam01551
325240001824	preprotein translocase subunit SecA; Reviewed; Region: PRK13107
325240001825	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
325240001826	SEC-C motif; Region: SEC-C; pfam02810
325240001827	anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718
325240001828	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
325240001829	substrate binding site [chemical binding]; other site
325240001830	active site
325240001831	PAS fold; Region: PAS_4; pfam08448
325240001832	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240001833	putative active site [active]
325240001834	heme pocket [chemical binding]; other site
325240001835	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240001836	active site
325240001837	I-site; other site
325240001838	metal binding site [ion binding]; metal-binding site
325240001839	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240001840	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332
325240001841	short chain dehydrogenase; Provisional; Region: PRK06181
325240001842	NADP binding site [chemical binding]; other site
325240001843	homodimer interface [polypeptide binding]; other site
325240001844	substrate binding site [chemical binding]; other site
325240001845	active site
325240001846	Peptidase M60-like family; Region: M60-like; pfam13402
325240001847	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
325240001848	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
325240001849	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
325240001850	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
325240001851	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
325240001852	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
325240001853	purine monophosphate binding site [chemical binding]; other site
325240001854	dimer interface [polypeptide binding]; other site
325240001855	putative catalytic residues [active]
325240001856	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
325240001857	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
325240001858	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
325240001859	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
325240001860	DNA binding residues [nucleotide binding]
325240001861	dimer interface [polypeptide binding]; other site
325240001862	metal binding site [ion binding]; metal-binding site
325240001863	Predicted permease; Region: DUF318; cl17795
325240001864	Predicted permease; Region: DUF318; cl17795
325240001865	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
325240001866	SPFH domain / Band 7 family; Region: Band_7; pfam01145
325240001867	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
325240001868	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
325240001869	RNA binding surface [nucleotide binding]; other site
325240001870	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
325240001871	active site
325240001872	uracil binding [chemical binding]; other site
325240001873	putative MFS family transporter protein; Provisional; Region: PRK03633
325240001874	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
325240001875	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
325240001876	transmembrane helices; other site
325240001877	thioredoxin 2; Provisional; Region: PRK10996
325240001878	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
325240001879	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
325240001880	catalytic residues [active]
325240001881	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
325240001882	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240001883	putative active site [active]
325240001884	PAS fold; Region: PAS_3; pfam08447
325240001885	heme pocket [chemical binding]; other site
325240001886	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240001887	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240001888	metal binding site [ion binding]; metal-binding site
325240001889	active site
325240001890	I-site; other site
325240001891	Domain of unknown function (DUF1850); Region: DUF1850; pfam08905
325240001892	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
325240001893	DctM-like transporters; Region: DctM; pfam06808
325240001894	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
325240001895	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
325240001896	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
325240001897	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
325240001898	conjugal transfer protein TraV; Provisional; Region: PRK13733
325240001899	Poxvirus P35 protein; Region: Pox_P35; pfam03213
325240001900	Predicted metalloprotease [General function prediction only]; Region: COG2321
325240001901	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
325240001902	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
325240001903	nudix motif; other site
325240001904	Methyltransferase domain; Region: Methyltransf_31; pfam13847
325240001905	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240001906	S-adenosylmethionine binding site [chemical binding]; other site
325240001907	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
325240001908	Part of AAA domain; Region: AAA_19; pfam13245
325240001909	Family description; Region: UvrD_C_2; pfam13538
325240001910	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
325240001911	UbiA prenyltransferase family; Region: UbiA; pfam01040
325240001912	TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936
325240001913	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
325240001914	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
325240001915	putative dimer interface [polypeptide binding]; other site
325240001916	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
325240001917	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
325240001918	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
325240001919	FMN binding site [chemical binding]; other site
325240001920	substrate binding site [chemical binding]; other site
325240001921	putative catalytic residue [active]
325240001922	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
325240001923	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
325240001924	catalytic residues [active]
325240001925	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
325240001926	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
325240001927	catalytic residues [active]
325240001928	Domain of unknown function DUF20; Region: UPF0118; pfam01594
325240001929	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
325240001930	Pathogenicity locus; Region: Cdd1; pfam11731
325240001931	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530
325240001932	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
325240001933	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
325240001934	active site
325240001935	Zn binding site [ion binding]; other site
325240001936	Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934
325240001937	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
325240001938	Transposase; Region: HTH_Tnp_1; cl17663
325240001939	Winged helix-turn helix; Region: HTH_29; pfam13551
325240001940	Homeodomain-like domain; Region: HTH_32; pfam13565
325240001941	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
325240001942	Integrase core domain; Region: rve; pfam00665
325240001943	Integrase core domain; Region: rve_3; pfam13683
325240001944	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
325240001945	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240001946	Transposase; Region: HTH_Tnp_1; pfam01527
325240001947	HTH-like domain; Region: HTH_21; pfam13276
325240001948	Integrase core domain; Region: rve; pfam00665
325240001949	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240001950	FMN reductase; Validated; Region: fre; PRK08051
325240001951	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
325240001952	FAD binding pocket [chemical binding]; other site
325240001953	FAD binding motif [chemical binding]; other site
325240001954	phosphate binding motif [ion binding]; other site
325240001955	beta-alpha-beta structure motif; other site
325240001956	NAD binding pocket [chemical binding]; other site
325240001957	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
325240001958	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
325240001959	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240001960	putative substrate translocation pore; other site
325240001961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
325240001962	NAD(P) binding site [chemical binding]; other site
325240001963	active site
325240001964	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
325240001965	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
325240001966	carboxyltransferase (CT) interaction site; other site
325240001967	biotinylation site [posttranslational modification]; other site
325240001968	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
325240001969	Dehydroquinase class II; Region: DHquinase_II; pfam01220
325240001970	active site
325240001971	trimer interface [polypeptide binding]; other site
325240001972	dimer interface [polypeptide binding]; other site
325240001973	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
325240001974	hypothetical protein; Provisional; Region: PRK09256
325240001975	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
325240001976	Protein of unknown function (DUF3012); Region: DUF3012; pfam11216
325240001977	Outer membrane efflux protein; Region: OEP; pfam02321
325240001978	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
325240001979	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
325240001980	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240001981	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
325240001982	Protein export membrane protein; Region: SecD_SecF; cl14618
325240001983	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
325240001984	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
325240001985	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
325240001986	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240001987	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240001988	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
325240001989	putative effector binding pocket; other site
325240001990	dimerization interface [polypeptide binding]; other site
325240001991	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
325240001992	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
325240001993	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240001994	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
325240001995	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240001996	putative substrate translocation pore; other site
325240001997	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240001998	putative substrate translocation pore; other site
325240001999	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
325240002000	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240002001	Coenzyme A binding pocket [chemical binding]; other site
325240002002	Uncharacterized conserved protein [Function unknown]; Region: COG1359
325240002003	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
325240002004	Radical SAM superfamily; Region: Radical_SAM; pfam04055
325240002005	FeS/SAM binding site; other site
325240002006	Isochorismatase family; Region: Isochorismatase; pfam00857
325240002007	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
325240002008	catalytic triad [active]
325240002009	conserved cis-peptide bond; other site
325240002010	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
325240002011	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
325240002012	conserved cys residue [active]
325240002013	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
325240002014	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
325240002015	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
325240002016	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240002017	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
325240002018	dimerization interface [polypeptide binding]; other site
325240002019	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
325240002020	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
325240002021	dimerization interface [polypeptide binding]; other site
325240002022	putative DNA binding site [nucleotide binding]; other site
325240002023	putative Zn2+ binding site [ion binding]; other site
325240002024	Predicted permeases [General function prediction only]; Region: COG0701
325240002025	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
325240002026	catalytic residues [active]
325240002027	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
325240002028	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
325240002029	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
325240002030	Major Facilitator Superfamily; Region: MFS_1; pfam07690
325240002031	Protein of unknown function (DUF2927); Region: DUF2927; pfam11150
325240002032	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
325240002033	amino acid carrier protein; Region: agcS; TIGR00835
325240002034	conserved hypothetical protein; Region: QEGLA; TIGR02421
325240002035	CHASE domain; Region: CHASE; pfam03924
325240002036	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
325240002037	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240002038	putative active site [active]
325240002039	heme pocket [chemical binding]; other site
325240002040	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240002041	dimer interface [polypeptide binding]; other site
325240002042	phosphorylation site [posttranslational modification]
325240002043	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240002044	ATP binding site [chemical binding]; other site
325240002045	Mg2+ binding site [ion binding]; other site
325240002046	G-X-G motif; other site
325240002047	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240002048	active site
325240002049	phosphorylation site [posttranslational modification]
325240002050	intermolecular recognition site; other site
325240002051	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
325240002052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240002053	active site
325240002054	phosphorylation site [posttranslational modification]
325240002055	intermolecular recognition site; other site
325240002056	dimerization interface [polypeptide binding]; other site
325240002057	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240002058	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240002059	metal binding site [ion binding]; metal-binding site
325240002060	active site
325240002061	I-site; other site
325240002062	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240002063	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
325240002064	ATP-grasp domain; Region: ATP-grasp_4; cl17255
325240002065	conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001
325240002066	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
325240002067	IHF dimer interface [polypeptide binding]; other site
325240002068	IHF - DNA interface [nucleotide binding]; other site
325240002069	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
325240002070	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240002071	active site
325240002072	phosphorylation site [posttranslational modification]
325240002073	intermolecular recognition site; other site
325240002074	dimerization interface [polypeptide binding]; other site
325240002075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240002076	Response regulator receiver domain; Region: Response_reg; pfam00072
325240002077	active site
325240002078	phosphorylation site [posttranslational modification]
325240002079	intermolecular recognition site; other site
325240002080	dimerization interface [polypeptide binding]; other site
325240002081	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
325240002082	Protein of unknown function (DUF3016); Region: DUF3016; pfam11454
325240002083	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240002084	FOG: CBS domain [General function prediction only]; Region: COG0517
325240002085	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
325240002086	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240002087	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240002088	metal binding site [ion binding]; metal-binding site
325240002089	active site
325240002090	I-site; other site
325240002091	TraB family; Region: TraB; pfam01963
325240002092	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
325240002093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240002094	S-adenosylmethionine binding site [chemical binding]; other site
325240002095	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
325240002096	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
325240002097	active site 2 [active]
325240002098	active site 1 [active]
325240002099	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
325240002100	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
325240002101	active site
325240002102	catalytic tetrad [active]
325240002103	formate--tetrahydrofolate ligase; Provisional; Region: PRK13506
325240002104	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
325240002105	Potassium binding sites [ion binding]; other site
325240002106	Cesium cation binding sites [ion binding]; other site
325240002107	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
325240002108	Mechanosensitive ion channel; Region: MS_channel; pfam00924
325240002109	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
325240002110	Periplasmic binding protein TroA_c.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_c; cd01145
325240002111	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
325240002112	putative ligand binding site [chemical binding]; other site
325240002113	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
325240002114	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
325240002115	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
325240002116	putative acyl-acceptor binding pocket; other site
325240002117	RNase E inhibitor protein; Provisional; Region: PRK11191
325240002118	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
325240002119	PAS domain; Region: PAS_9; pfam13426
325240002120	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240002121	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240002122	metal binding site [ion binding]; metal-binding site
325240002123	active site
325240002124	I-site; other site
325240002125	Response regulator receiver domain; Region: Response_reg; pfam00072
325240002126	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240002127	active site
325240002128	phosphorylation site [posttranslational modification]
325240002129	intermolecular recognition site; other site
325240002130	dimerization interface [polypeptide binding]; other site
325240002131	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
325240002132	enoyl-CoA hydratase; Provisional; Region: PRK07509
325240002133	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
325240002134	substrate binding site [chemical binding]; other site
325240002135	oxyanion hole (OAH) forming residues; other site
325240002136	trimer interface [polypeptide binding]; other site
325240002137	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
325240002138	ATP-dependent helicase HepA; Validated; Region: PRK04914
325240002139	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
325240002140	ATP binding site [chemical binding]; other site
325240002141	putative Mg++ binding site [ion binding]; other site
325240002142	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240002143	nucleotide binding region [chemical binding]; other site
325240002144	ATP-binding site [chemical binding]; other site
325240002145	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
325240002146	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
325240002147	putative active site [active]
325240002148	PhoH-like protein; Region: PhoH; pfam02562
325240002149	Cache domain; Region: Cache_1; pfam02743
325240002150	PAS fold; Region: PAS_4; pfam08448
325240002151	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240002152	putative active site [active]
325240002153	heme pocket [chemical binding]; other site
325240002154	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240002155	PAS fold; Region: PAS_3; pfam08447
325240002156	putative active site [active]
325240002157	heme pocket [chemical binding]; other site
325240002158	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240002159	dimer interface [polypeptide binding]; other site
325240002160	phosphorylation site [posttranslational modification]
325240002161	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240002162	ATP binding site [chemical binding]; other site
325240002163	Mg2+ binding site [ion binding]; other site
325240002164	G-X-G motif; other site
325240002165	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240002166	Response regulator receiver domain; Region: Response_reg; pfam00072
325240002167	active site
325240002168	phosphorylation site [posttranslational modification]
325240002169	intermolecular recognition site; other site
325240002170	dimerization interface [polypeptide binding]; other site
325240002171	Response regulator receiver domain; Region: Response_reg; pfam00072
325240002172	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240002173	active site
325240002174	phosphorylation site [posttranslational modification]
325240002175	intermolecular recognition site; other site
325240002176	dimerization interface [polypeptide binding]; other site
325240002177	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
325240002178	active site
325240002179	Protein kinase domain; Region: Pkinase; pfam00069
325240002180	Catalytic domain of Protein Kinases; Region: PKc; cd00180
325240002181	active site
325240002182	ATP binding site [chemical binding]; other site
325240002183	substrate binding site [chemical binding]; other site
325240002184	activation loop (A-loop); other site
325240002185	thiopurine S-methyltransferase; Reviewed; Region: PRK13255
325240002186	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
325240002187	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240002188	PAS fold; Region: PAS_3; pfam08447
325240002189	putative active site [active]
325240002190	heme pocket [chemical binding]; other site
325240002191	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
325240002192	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240002193	dimer interface [polypeptide binding]; other site
325240002194	putative CheW interface [polypeptide binding]; other site
325240002195	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
325240002196	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
325240002197	NAD binding site [chemical binding]; other site
325240002198	ligand binding site [chemical binding]; other site
325240002199	catalytic site [active]
325240002200	Protein of unknown function (DUF3392); Region: DUF3392; pfam11872
325240002201	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
325240002202	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
325240002203	active site
325240002204	catalytic site [active]
325240002205	putative mechanosensitive channel protein; Provisional; Region: PRK10929
325240002206	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
325240002207	Mechanosensitive ion channel; Region: MS_channel; pfam00924
325240002208	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
325240002209	EamA-like transporter family; Region: EamA; pfam00892
325240002210	EamA-like transporter family; Region: EamA; pfam00892
325240002211	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
325240002212	GTPase RsgA; Reviewed; Region: PRK12288
325240002213	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
325240002214	RNA binding site [nucleotide binding]; other site
325240002215	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
325240002216	GTPase/Zn-binding domain interface [polypeptide binding]; other site
325240002217	GTP/Mg2+ binding site [chemical binding]; other site
325240002218	G4 box; other site
325240002219	G5 box; other site
325240002220	G1 box; other site
325240002221	Switch I region; other site
325240002222	G2 box; other site
325240002223	G3 box; other site
325240002224	Switch II region; other site
325240002225	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
325240002226	catalytic site [active]
325240002227	putative active site [active]
325240002228	putative substrate binding site [chemical binding]; other site
325240002229	dimer interface [polypeptide binding]; other site
325240002230	putative carbohydrate kinase; Provisional; Region: PRK10565
325240002231	Uncharacterized conserved protein [Function unknown]; Region: COG0062
325240002232	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
325240002233	putative substrate binding site [chemical binding]; other site
325240002234	putative ATP binding site [chemical binding]; other site
325240002235	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
325240002236	AMIN domain; Region: AMIN; pfam11741
325240002237	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
325240002238	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
325240002239	active site
325240002240	metal binding site [ion binding]; metal-binding site
325240002241	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
325240002242	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
325240002243	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
325240002244	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240002245	ATP binding site [chemical binding]; other site
325240002246	Mg2+ binding site [ion binding]; other site
325240002247	G-X-G motif; other site
325240002248	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
325240002249	ATP binding site [chemical binding]; other site
325240002250	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
325240002251	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
325240002252	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
325240002253	bacterial Hfq-like; Region: Hfq; cd01716
325240002254	hexamer interface [polypeptide binding]; other site
325240002255	Sm1 motif; other site
325240002256	RNA binding site [nucleotide binding]; other site
325240002257	Sm2 motif; other site
325240002258	GTPase HflX; Provisional; Region: PRK11058
325240002259	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
325240002260	HflX GTPase family; Region: HflX; cd01878
325240002261	G1 box; other site
325240002262	GTP/Mg2+ binding site [chemical binding]; other site
325240002263	Switch I region; other site
325240002264	G2 box; other site
325240002265	G3 box; other site
325240002266	Switch II region; other site
325240002267	G4 box; other site
325240002268	G5 box; other site
325240002269	FtsH protease regulator HflK; Provisional; Region: PRK10930
325240002270	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
325240002271	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
325240002272	FtsH protease regulator HflC; Provisional; Region: PRK11029
325240002273	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
325240002274	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
325240002275	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
325240002276	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
325240002277	[2Fe-2S] cluster binding site [ion binding]; other site
325240002278	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
325240002279	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
325240002280	Qi binding site; other site
325240002281	intrachain domain interface; other site
325240002282	interchain domain interface [polypeptide binding]; other site
325240002283	heme bH binding site [chemical binding]; other site
325240002284	heme bL binding site [chemical binding]; other site
325240002285	Qo binding site; other site
325240002286	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
325240002287	interchain domain interface [polypeptide binding]; other site
325240002288	intrachain domain interface; other site
325240002289	Qi binding site; other site
325240002290	Qo binding site; other site
325240002291	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
325240002292	stringent starvation protein A; Provisional; Region: sspA; PRK09481
325240002293	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
325240002294	C-terminal domain interface [polypeptide binding]; other site
325240002295	putative GSH binding site (G-site) [chemical binding]; other site
325240002296	dimer interface [polypeptide binding]; other site
325240002297	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
325240002298	dimer interface [polypeptide binding]; other site
325240002299	N-terminal domain interface [polypeptide binding]; other site
325240002300	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
325240002301	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
325240002302	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
325240002303	glutamine binding [chemical binding]; other site
325240002304	catalytic triad [active]
325240002305	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
325240002306	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
325240002307	HDOD domain; Region: HDOD; pfam08668
325240002308	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
325240002309	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
325240002310	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
325240002311	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
325240002312	inhibitor-cofactor binding pocket; inhibition site
325240002313	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240002314	catalytic residue [active]
325240002315	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
325240002316	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
325240002317	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
325240002318	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
325240002319	NAD(P) binding site [chemical binding]; other site
325240002320	catalytic residues [active]
325240002321	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
325240002322	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
325240002323	HAMP domain; Region: HAMP; pfam00672
325240002324	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
325240002325	dimer interface [polypeptide binding]; other site
325240002326	phosphorylation site [posttranslational modification]
325240002327	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240002328	ATP binding site [chemical binding]; other site
325240002329	Mg2+ binding site [ion binding]; other site
325240002330	G-X-G motif; other site
325240002331	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
325240002332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240002333	active site
325240002334	phosphorylation site [posttranslational modification]
325240002335	intermolecular recognition site; other site
325240002336	dimerization interface [polypeptide binding]; other site
325240002337	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
325240002338	DNA binding site [nucleotide binding]
325240002339	Predicted membrane protein [Function unknown]; Region: COG3212
325240002340	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
325240002341	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
325240002342	ligand binding site [chemical binding]; other site
325240002343	flexible hinge region; other site
325240002344	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
325240002345	putative switch regulator; other site
325240002346	non-specific DNA interactions [nucleotide binding]; other site
325240002347	DNA binding site [nucleotide binding]
325240002348	sequence specific DNA binding site [nucleotide binding]; other site
325240002349	putative cAMP binding site [chemical binding]; other site
325240002350	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
325240002351	Sel1-like repeats; Region: SEL1; smart00671
325240002352	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240002353	TPR motif; other site
325240002354	binding surface
325240002355	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
325240002356	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
325240002357	GAF domain; Region: GAF; cl17456
325240002358	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240002359	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240002360	metal binding site [ion binding]; metal-binding site
325240002361	active site
325240002362	I-site; other site
325240002363	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240002364	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
325240002365	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
325240002366	ATP binding site [chemical binding]; other site
325240002367	putative Mg++ binding site [ion binding]; other site
325240002368	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240002369	nucleotide binding region [chemical binding]; other site
325240002370	ATP-binding site [chemical binding]; other site
325240002371	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
325240002372	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
325240002373	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
325240002374	Transglycosylase; Region: Transgly; pfam00912
325240002375	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
325240002376	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
325240002377	Protein of unknown function (DUF3581); Region: DUF3581; pfam12119
325240002378	PAS domain; Region: PAS_9; pfam13426
325240002379	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240002380	putative active site [active]
325240002381	heme pocket [chemical binding]; other site
325240002382	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240002383	PAS domain; Region: PAS_9; pfam13426
325240002384	putative active site [active]
325240002385	heme pocket [chemical binding]; other site
325240002386	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240002387	dimer interface [polypeptide binding]; other site
325240002388	putative CheW interface [polypeptide binding]; other site
325240002389	tetrathionate reductase subunit A; Provisional; Region: PRK14991
325240002390	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
325240002391	molybdopterin cofactor binding site; other site
325240002392	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
325240002393	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
325240002394	putative molybdopterin cofactor binding site; other site
325240002395	tetrathionate reductase subunit C; Provisional; Region: PRK14992
325240002396	tetrathionate reductase subunit B; Provisional; Region: PRK14993
325240002397	4Fe-4S binding domain; Region: Fer4; pfam00037
325240002398	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
325240002399	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
325240002400	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240002401	dimer interface [polypeptide binding]; other site
325240002402	phosphorylation site [posttranslational modification]
325240002403	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240002404	ATP binding site [chemical binding]; other site
325240002405	Mg2+ binding site [ion binding]; other site
325240002406	G-X-G motif; other site
325240002407	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
325240002408	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240002409	active site
325240002410	phosphorylation site [posttranslational modification]
325240002411	intermolecular recognition site; other site
325240002412	dimerization interface [polypeptide binding]; other site
325240002413	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
325240002414	DNA binding residues [nucleotide binding]
325240002415	dimerization interface [polypeptide binding]; other site
325240002416	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
325240002417	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
325240002418	active site
325240002419	metal binding site [ion binding]; metal-binding site
325240002420	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
325240002421	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
325240002422	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240002423	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240002424	Walker A motif; other site
325240002425	ATP binding site [chemical binding]; other site
325240002426	Walker B motif; other site
325240002427	Integrase core domain; Region: rve; pfam00665
325240002428	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
325240002429	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
325240002430	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
325240002431	dimer interface [polypeptide binding]; other site
325240002432	conserved gate region; other site
325240002433	putative PBP binding loops; other site
325240002434	ABC-ATPase subunit interface; other site
325240002435	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
325240002436	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
325240002437	Walker A/P-loop; other site
325240002438	ATP binding site [chemical binding]; other site
325240002439	Q-loop/lid; other site
325240002440	ABC transporter signature motif; other site
325240002441	Walker B; other site
325240002442	D-loop; other site
325240002443	H-loop/switch region; other site
325240002444	TOBE domain; Region: TOBE_2; pfam08402
325240002445	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
325240002446	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
325240002447	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
325240002448	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240002449	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240002450	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
325240002451	putative effector binding pocket; other site
325240002452	dimerization interface [polypeptide binding]; other site
325240002453	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
325240002454	NADH(P)-binding; Region: NAD_binding_10; pfam13460
325240002455	NAD binding site [chemical binding]; other site
325240002456	substrate binding site [chemical binding]; other site
325240002457	putative active site [active]
325240002458	arginine repressor; Provisional; Region: PRK05066
325240002459	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
325240002460	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
325240002461	malate dehydrogenase; Provisional; Region: PRK05086
325240002462	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
325240002463	NAD binding site [chemical binding]; other site
325240002464	dimerization interface [polypeptide binding]; other site
325240002465	Substrate binding site [chemical binding]; other site
325240002466	Protein of unknown function, DUF393; Region: DUF393; pfam04134
325240002467	dihydromonapterin reductase; Provisional; Region: PRK06483
325240002468	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
325240002469	NAD(P) binding site [chemical binding]; other site
325240002470	active site
325240002471	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
325240002472	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
325240002473	Cell division protein ZapA; Region: ZapA; pfam05164
325240002474	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
325240002475	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
325240002476	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
325240002477	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
325240002478	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
325240002479	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
325240002480	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
325240002481	glycine cleavage system protein H; Provisional; Region: PRK13380
325240002482	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
325240002483	lipoyl attachment site [posttranslational modification]; other site
325240002484	glycine dehydrogenase; Provisional; Region: PRK05367
325240002485	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
325240002486	tetramer interface [polypeptide binding]; other site
325240002487	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240002488	catalytic residue [active]
325240002489	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
325240002490	tetramer interface [polypeptide binding]; other site
325240002491	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240002492	catalytic residue [active]
325240002493	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
325240002494	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
325240002495	Uncharacterized conserved protein [Function unknown]; Region: COG0398
325240002496	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
325240002497	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
325240002498	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
325240002499	NADH(P)-binding; Region: NAD_binding_10; pfam13460
325240002500	NAD(P) binding site [chemical binding]; other site
325240002501	putative active site [active]
325240002502	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
325240002503	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
325240002504	NAD binding site [chemical binding]; other site
325240002505	active site
325240002506	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
325240002507	putative hydrophobic ligand binding site [chemical binding]; other site
325240002508	protein interface [polypeptide binding]; other site
325240002509	gate; other site
325240002510	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
325240002511	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
325240002512	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
325240002513	FMN binding site [chemical binding]; other site
325240002514	active site
325240002515	substrate binding site [chemical binding]; other site
325240002516	catalytic residue [active]
325240002517	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
325240002518	active site
325240002519	dimer interface [polypeptide binding]; other site
325240002520	motif 1; other site
325240002521	motif 2; other site
325240002522	motif 3; other site
325240002523	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
325240002524	anticodon binding site; other site
325240002525	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240002526	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240002527	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
325240002528	putative effector binding pocket; other site
325240002529	putative dimerization interface [polypeptide binding]; other site
325240002530	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
325240002531	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240002532	putative substrate translocation pore; other site
325240002533	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
325240002534	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
325240002535	putative NAD(P) binding site [chemical binding]; other site
325240002536	putative substrate binding site [chemical binding]; other site
325240002537	catalytic Zn binding site [ion binding]; other site
325240002538	structural Zn binding site [ion binding]; other site
325240002539	dimer interface [polypeptide binding]; other site
325240002540	Uncharacterized conserved protein [Function unknown]; Region: COG4925
325240002541	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
325240002542	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240002543	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240002544	metal binding site [ion binding]; metal-binding site
325240002545	active site
325240002546	I-site; other site
325240002547	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
325240002548	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
325240002549	Ribosome recycling factor; Region: RRF_GI; pfam12614
325240002550	Cache domain; Region: Cache_2; pfam08269
325240002551	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240002552	dimerization interface [polypeptide binding]; other site
325240002553	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
325240002554	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240002555	dimer interface [polypeptide binding]; other site
325240002556	putative CheW interface [polypeptide binding]; other site
325240002557	YcaO domain protein; Region: TIGR03549
325240002558	OsmC-like protein; Region: OsmC; pfam02566
325240002559	YcaO-like family; Region: YcaO; pfam02624
325240002560	Mannan-binding protein; Region: MVL; pfam12151
325240002561	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240002562	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240002563	metal binding site [ion binding]; metal-binding site
325240002564	active site
325240002565	I-site; other site
325240002566	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
325240002567	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
325240002568	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
325240002569	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
325240002570	substrate binding pocket [chemical binding]; other site
325240002571	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
325240002572	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
325240002573	FOG: CBS domain [General function prediction only]; Region: COG0517
325240002574	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
325240002575	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
325240002576	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
325240002577	putative active site [active]
325240002578	putative metal binding site [ion binding]; other site
325240002579	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
325240002580	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
325240002581	active site
325240002582	Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560
325240002583	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
325240002584	putative active site [active]
325240002585	catalytic site [active]
325240002586	putative metal binding site [ion binding]; other site
325240002587	Protein of unknown function (DUF3622); Region: DUF3622; pfam12286
325240002588	Transposase; Region: HTH_Tnp_1; pfam01527
325240002589	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240002590	putative transposase OrfB; Reviewed; Region: PHA02517
325240002591	HTH-like domain; Region: HTH_21; pfam13276
325240002592	Integrase core domain; Region: rve; pfam00665
325240002593	Integrase core domain; Region: rve_2; pfam13333
325240002594	Protein of unknown function (DUF3103); Region: DUF3103; pfam11301
325240002595	azurin; Region: azurin; TIGR02695
325240002596	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
325240002597	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
325240002598	substrate binding site [chemical binding]; other site
325240002599	dimer interface [polypeptide binding]; other site
325240002600	ATP binding site [chemical binding]; other site
325240002601	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
325240002602	active site
325240002603	tetramer interface [polypeptide binding]; other site
325240002604	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
325240002605	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
325240002606	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
325240002607	N-terminal plug; other site
325240002608	ligand-binding site [chemical binding]; other site
325240002609	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
325240002610	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
325240002611	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240002612	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
325240002613	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240002614	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240002615	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
325240002616	putative dimerization interface [polypeptide binding]; other site
325240002617	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
325240002618	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
325240002619	THF binding site; other site
325240002620	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
325240002621	substrate binding site [chemical binding]; other site
325240002622	THF binding site; other site
325240002623	zinc-binding site [ion binding]; other site
325240002624	Inclusion body protein; Region: PixA; pfam12306
325240002625	epoxyqueuosine reductase; Region: TIGR00276
325240002626	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
325240002627	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240002628	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240002629	metal binding site [ion binding]; metal-binding site
325240002630	active site
325240002631	I-site; other site
325240002632	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240002633	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240002634	Integrase core domain; Region: rve; pfam00665
325240002635	Tetratricopeptide repeat; Region: TPR_12; pfam13424
325240002636	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
325240002637	TPR motif; other site
325240002638	binding surface
325240002639	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
325240002640	active site
325240002641	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
325240002642	Protein of unknown function (DUF3069); Region: DUF3069; pfam11269
325240002643	malate dehydrogenase; Provisional; Region: PRK13529
325240002644	Malic enzyme, N-terminal domain; Region: malic; pfam00390
325240002645	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
325240002646	NAD(P) binding site [chemical binding]; other site
325240002647	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
325240002648	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
325240002649	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
325240002650	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
325240002651	Bacterial PH domain; Region: DUF304; pfam03703
325240002652	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
325240002653	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
325240002654	N-terminal plug; other site
325240002655	ligand-binding site [chemical binding]; other site
325240002656	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
325240002657	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
325240002658	putative C-terminal domain interface [polypeptide binding]; other site
325240002659	putative GSH binding site (G-site) [chemical binding]; other site
325240002660	putative dimer interface [polypeptide binding]; other site
325240002661	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
325240002662	dimer interface [polypeptide binding]; other site
325240002663	N-terminal domain interface [polypeptide binding]; other site
325240002664	substrate binding pocket (H-site) [chemical binding]; other site
325240002665	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
325240002666	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
325240002667	synthetase active site [active]
325240002668	NTP binding site [chemical binding]; other site
325240002669	metal binding site [ion binding]; metal-binding site
325240002670	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
325240002671	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
325240002672	active site
325240002673	Zn binding site [ion binding]; other site
325240002674	maltose O-acetyltransferase; Provisional; Region: PRK10092
325240002675	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
325240002676	trimer interface [polypeptide binding]; other site
325240002677	active site
325240002678	substrate binding site [chemical binding]; other site
325240002679	CoA binding site [chemical binding]; other site
325240002680	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
325240002681	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
325240002682	RNA binding surface [nucleotide binding]; other site
325240002683	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
325240002684	active site
325240002685	uracil binding [chemical binding]; other site
325240002686	Uncharacterized conserved protein [Function unknown]; Region: COG3595
325240002687	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
325240002688	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
325240002689	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
325240002690	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
325240002691	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
325240002692	DNA binding residues [nucleotide binding]
325240002693	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
325240002694	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240002695	dimerization interface [polypeptide binding]; other site
325240002696	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240002697	dimer interface [polypeptide binding]; other site
325240002698	putative CheW interface [polypeptide binding]; other site
325240002699	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
325240002700	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
325240002701	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
325240002702	active site
325240002703	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
325240002704	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
325240002705	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
325240002706	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
325240002707	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
325240002708	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
325240002709	tRNA; other site
325240002710	putative tRNA binding site [nucleotide binding]; other site
325240002711	putative NADP binding site [chemical binding]; other site
325240002712	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
325240002713	peptide chain release factor 1; Validated; Region: prfA; PRK00591
325240002714	This domain is found in peptide chain release factors; Region: PCRF; smart00937
325240002715	RF-1 domain; Region: RF-1; pfam00472
325240002716	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
325240002717	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240002718	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
325240002719	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240002720	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
325240002721	Coenzyme A binding pocket [chemical binding]; other site
325240002722	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
325240002723	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
325240002724	Tetratricopeptide repeat; Region: TPR_9; pfam13371
325240002725	Protein of unknown function (DUF819); Region: DUF819; cl02317
325240002726	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
325240002727	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
325240002728	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
325240002729	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
325240002730	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240002731	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
325240002732	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
325240002733	Nitrogen regulatory protein P-II; Region: P-II; smart00938
325240002734	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
325240002735	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
325240002736	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
325240002737	Predicted integral membrane protein [Function unknown]; Region: COG5652
325240002738	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
325240002739	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
325240002740	Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000
325240002741	muropeptide transporter; Reviewed; Region: ampG; PRK11902
325240002742	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240002743	putative substrate translocation pore; other site
325240002744	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
325240002745	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
325240002746	substrate binding site [chemical binding]; other site
325240002747	hypothetical protein; Provisional; Region: PRK11627
325240002748	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
325240002749	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
325240002750	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
325240002751	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
325240002752	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
325240002753	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
325240002754	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
325240002755	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
325240002756	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
325240002757	aromatic acid decarboxylase; Validated; Region: PRK05920
325240002758	Flavoprotein; Region: Flavoprotein; pfam02441
325240002759	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
325240002760	active site
325240002761	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
325240002762	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
325240002763	Walker A/P-loop; other site
325240002764	ATP binding site [chemical binding]; other site
325240002765	Q-loop/lid; other site
325240002766	ABC transporter signature motif; other site
325240002767	Walker B; other site
325240002768	D-loop; other site
325240002769	H-loop/switch region; other site
325240002770	inner membrane transport permease; Provisional; Region: PRK15066
325240002771	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
325240002772	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
325240002773	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240002774	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
325240002775	putative transposase OrfB; Reviewed; Region: PHA02517
325240002776	HTH-like domain; Region: HTH_21; pfam13276
325240002777	Integrase core domain; Region: rve; pfam00665
325240002778	Integrase core domain; Region: rve_3; pfam13683
325240002779	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240002780	Transposase; Region: HTH_Tnp_1; pfam01527
325240002781	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
325240002782	active site
325240002783	catalytic residues [active]
325240002784	PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818
325240002785	PA/protease or protease-like domain interface [polypeptide binding]; other site
325240002786	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
325240002787	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
325240002788	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
325240002789	Helix-turn-helix domain; Region: HTH_28; pfam13518
325240002790	Winged helix-turn helix; Region: HTH_29; pfam13551
325240002791	Homeodomain-like domain; Region: HTH_32; pfam13565
325240002792	Integrase core domain; Region: rve; pfam00665
325240002793	DDE domain; Region: DDE_Tnp_IS240; pfam13610
325240002794	Integrase core domain; Region: rve_3; pfam13683
325240002795	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
325240002796	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
325240002797	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
325240002798	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
325240002799	putative DNA binding site [nucleotide binding]; other site
325240002800	putative Zn2+ binding site [ion binding]; other site
325240002801	AsnC family; Region: AsnC_trans_reg; pfam01037
325240002802	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
325240002803	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
325240002804	active site
325240002805	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
325240002806	Peptidase family U32; Region: Peptidase_U32; pfam01136
325240002807	Collagenase; Region: DUF3656; pfam12392
325240002808	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
325240002809	pentamer interface [polypeptide binding]; other site
325240002810	dodecaamer interface [polypeptide binding]; other site
325240002811	CAAX protease self-immunity; Region: Abi; pfam02517
325240002812	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
325240002813	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
325240002814	Cupin domain; Region: Cupin_2; cl17218
325240002815	Predicted ATPase [General function prediction only]; Region: COG4637
325240002816	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240002817	Walker A/P-loop; other site
325240002818	ATP binding site [chemical binding]; other site
325240002819	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
325240002820	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
325240002821	active site
325240002822	Fe-S metabolism associated domain; Region: SufE; cl00951
325240002823	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
325240002824	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
325240002825	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
325240002826	catalytic residue [active]
325240002827	Cna protein B-type domain; Region: Cna_B_2; pfam13715
325240002828	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
325240002829	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240002830	MltA-interacting protein MipA; Region: MipA; cl01504
325240002831	Protein of unknown function (DUF3019); Region: DUF3019; pfam11456
325240002832	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
325240002833	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240002834	active site
325240002835	phosphorylation site [posttranslational modification]
325240002836	intermolecular recognition site; other site
325240002837	dimerization interface [polypeptide binding]; other site
325240002838	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
325240002839	DNA binding site [nucleotide binding]
325240002840	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
325240002841	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240002842	dimerization interface [polypeptide binding]; other site
325240002843	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240002844	dimer interface [polypeptide binding]; other site
325240002845	phosphorylation site [posttranslational modification]
325240002846	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240002847	ATP binding site [chemical binding]; other site
325240002848	Mg2+ binding site [ion binding]; other site
325240002849	G-X-G motif; other site
325240002850	MltA-interacting protein MipA; Region: MipA; cl01504
325240002851	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
325240002852	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
325240002853	active site
325240002854	catalytic tetrad [active]
325240002855	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
325240002856	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
325240002857	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
325240002858	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
325240002859	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
325240002860	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
325240002861	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
325240002862	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
325240002863	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
325240002864	catalytic loop [active]
325240002865	iron binding site [ion binding]; other site
325240002866	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
325240002867	FAD binding pocket [chemical binding]; other site
325240002868	FAD binding motif [chemical binding]; other site
325240002869	phosphate binding motif [ion binding]; other site
325240002870	beta-alpha-beta structure motif; other site
325240002871	NAD binding pocket [chemical binding]; other site
325240002872	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
325240002873	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
325240002874	active site
325240002875	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
325240002876	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
325240002877	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
325240002878	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
325240002879	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
325240002880	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
325240002881	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
325240002882	MarR family; Region: MarR; pfam01047
325240002883	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
325240002884	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240002885	Coenzyme A binding pocket [chemical binding]; other site
325240002886	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
325240002887	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
325240002888	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
325240002889	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
325240002890	active site
325240002891	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
325240002892	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
325240002893	serine transporter; Region: stp; TIGR00814
325240002894	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
325240002895	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240002896	Coenzyme A binding pocket [chemical binding]; other site
325240002897	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
325240002898	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
325240002899	META domain; Region: META; pfam03724
325240002900	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240002901	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240002902	metal binding site [ion binding]; metal-binding site
325240002903	active site
325240002904	I-site; other site
325240002905	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240002906	Coenzyme A binding pocket [chemical binding]; other site
325240002907	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
325240002908	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
325240002909	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
325240002910	ATP binding site [chemical binding]; other site
325240002911	putative Mg++ binding site [ion binding]; other site
325240002912	AAA domain; Region: AAA_13; pfam13166
325240002913	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240002914	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240002915	Walker A motif; other site
325240002916	ATP binding site [chemical binding]; other site
325240002917	Walker B motif; other site
325240002918	Integrase core domain; Region: rve; pfam00665
325240002919	hypothetical protein; Provisional; Region: PRK05208
325240002920	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240002921	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240002922	Integrase core domain; Region: rve; pfam00665
325240002923	fructose-1,6-bisphosphatase family protein; Region: PLN02628
325240002924	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
325240002925	AMP binding site [chemical binding]; other site
325240002926	metal binding site [ion binding]; metal-binding site
325240002927	active site
325240002928	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
325240002929	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
325240002930	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
325240002931	two-component response regulator; Provisional; Region: PRK11173
325240002932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240002933	active site
325240002934	phosphorylation site [posttranslational modification]
325240002935	intermolecular recognition site; other site
325240002936	dimerization interface [polypeptide binding]; other site
325240002937	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
325240002938	DNA binding site [nucleotide binding]
325240002939	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
325240002940	aspartate kinase III; Validated; Region: PRK09084
325240002941	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
325240002942	nucleotide binding site [chemical binding]; other site
325240002943	substrate binding site [chemical binding]; other site
325240002944	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
325240002945	dimer interface [polypeptide binding]; other site
325240002946	allosteric regulatory binding pocket; other site
325240002947	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
325240002948	dimer interface [polypeptide binding]; other site
325240002949	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
325240002950	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
325240002951	active site
325240002952	Zn binding site [ion binding]; other site
325240002953	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
325240002954	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
325240002955	Cl binding site [ion binding]; other site
325240002956	oligomer interface [polypeptide binding]; other site
325240002957	Uncharacterized protein family (UPF0231); Region: UPF0231; pfam06062
325240002958	transcriptional regulator NarL; Provisional; Region: PRK10651
325240002959	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240002960	active site
325240002961	phosphorylation site [posttranslational modification]
325240002962	intermolecular recognition site; other site
325240002963	dimerization interface [polypeptide binding]; other site
325240002964	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
325240002965	DNA binding residues [nucleotide binding]
325240002966	dimerization interface [polypeptide binding]; other site
325240002967	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
325240002968	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
325240002969	HAMP domain; Region: HAMP; pfam00672
325240002970	Histidine kinase; Region: HisKA_3; pfam07730
325240002971	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240002972	ATP binding site [chemical binding]; other site
325240002973	Mg2+ binding site [ion binding]; other site
325240002974	G-X-G motif; other site
325240002975	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
325240002976	Isochorismatase family; Region: Isochorismatase; pfam00857
325240002977	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
325240002978	catalytic triad [active]
325240002979	dimer interface [polypeptide binding]; other site
325240002980	conserved cis-peptide bond; other site
325240002981	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
325240002982	Nitrogen regulatory protein P-II; Region: P-II; smart00938
325240002983	probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644
325240002984	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240002985	binding surface
325240002986	TPR motif; other site
325240002987	Tetratricopeptide repeat; Region: TPR_12; pfam13424
325240002988	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240002989	binding surface
325240002990	TPR motif; other site
325240002991	TPR repeat; Region: TPR_11; pfam13414
325240002992	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
325240002993	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
325240002994	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
325240002995	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
325240002996	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240002997	Walker A/P-loop; other site
325240002998	ATP binding site [chemical binding]; other site
325240002999	Q-loop/lid; other site
325240003000	ABC transporter signature motif; other site
325240003001	Walker B; other site
325240003002	D-loop; other site
325240003003	H-loop/switch region; other site
325240003004	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
325240003005	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
325240003006	active site
325240003007	FMN binding site [chemical binding]; other site
325240003008	substrate binding site [chemical binding]; other site
325240003009	3Fe-4S cluster binding site [ion binding]; other site
325240003010	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
325240003011	catalytic core [active]
325240003012	ferredoxin-NADP reductase; Provisional; Region: PRK10926
325240003013	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
325240003014	FAD binding pocket [chemical binding]; other site
325240003015	FAD binding motif [chemical binding]; other site
325240003016	phosphate binding motif [ion binding]; other site
325240003017	beta-alpha-beta structure motif; other site
325240003018	NAD binding pocket [chemical binding]; other site
325240003019	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
325240003020	putative C-terminal domain interface [polypeptide binding]; other site
325240003021	putative GSH binding site (G-site) [chemical binding]; other site
325240003022	putative dimer interface [polypeptide binding]; other site
325240003023	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
325240003024	dimer interface [polypeptide binding]; other site
325240003025	N-terminal domain interface [polypeptide binding]; other site
325240003026	substrate binding pocket (H-site) [chemical binding]; other site
325240003027	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
325240003028	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240003029	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240003030	Walker A motif; other site
325240003031	ATP binding site [chemical binding]; other site
325240003032	Walker B motif; other site
325240003033	Integrase core domain; Region: rve; pfam00665
325240003034	AAA domain; Region: AAA_13; pfam13166
325240003035	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
325240003036	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
325240003037	Helix-turn-helix domain; Region: HTH_28; pfam13518
325240003038	Winged helix-turn helix; Region: HTH_29; pfam13551
325240003039	Homeodomain-like domain; Region: HTH_32; pfam13565
325240003040	Integrase core domain; Region: rve; pfam00665
325240003041	DDE domain; Region: DDE_Tnp_IS240; pfam13610
325240003042	Integrase core domain; Region: rve_3; pfam13683
325240003043	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
325240003044	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
325240003045	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
325240003046	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
325240003047	HsdM N-terminal domain; Region: HsdM_N; pfam12161
325240003048	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240003049	S-adenosylmethionine binding site [chemical binding]; other site
325240003050	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
325240003051	putative active site [active]
325240003052	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
325240003053	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
325240003054	non-specific DNA binding site [nucleotide binding]; other site
325240003055	salt bridge; other site
325240003056	sequence-specific DNA binding site [nucleotide binding]; other site
325240003057	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
325240003058	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
325240003059	active site
325240003060	catalytic residues [active]
325240003061	DNA binding site [nucleotide binding]
325240003062	Int/Topo IB signature motif; other site
325240003063	S-adenosylmethionine synthetase; Validated; Region: PRK05250
325240003064	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
325240003065	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
325240003066	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
325240003067	transketolase; Reviewed; Region: PRK12753
325240003068	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
325240003069	TPP-binding site [chemical binding]; other site
325240003070	dimer interface [polypeptide binding]; other site
325240003071	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
325240003072	PYR/PP interface [polypeptide binding]; other site
325240003073	dimer interface [polypeptide binding]; other site
325240003074	TPP binding site [chemical binding]; other site
325240003075	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
325240003076	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
325240003077	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
325240003078	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
325240003079	Phosphoglycerate kinase; Region: PGK; pfam00162
325240003080	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
325240003081	substrate binding site [chemical binding]; other site
325240003082	hinge regions; other site
325240003083	ADP binding site [chemical binding]; other site
325240003084	catalytic site [active]
325240003085	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
325240003086	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
325240003087	intersubunit interface [polypeptide binding]; other site
325240003088	active site
325240003089	zinc binding site [ion binding]; other site
325240003090	Na+ binding site [ion binding]; other site
325240003091	Protein of unknown function, DUF481; Region: DUF481; pfam04338
325240003092	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
325240003093	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
325240003094	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
325240003095	DNA binding site [nucleotide binding]
325240003096	PAS domain; Region: PAS_9; pfam13426
325240003097	PAS domain; Region: PAS_9; pfam13426
325240003098	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240003099	I-site; other site
325240003100	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
325240003101	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
325240003102	FeS/SAM binding site; other site
325240003103	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
325240003104	Protein export membrane protein; Region: SecD_SecF; cl14618
325240003105	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
325240003106	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240003107	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
325240003108	DEAD-like helicases superfamily; Region: DEXDc; smart00487
325240003109	ATP binding site [chemical binding]; other site
325240003110	Mg++ binding site [ion binding]; other site
325240003111	motif III; other site
325240003112	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240003113	nucleotide binding region [chemical binding]; other site
325240003114	ATP-binding site [chemical binding]; other site
325240003115	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
325240003116	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240003117	S-adenosylmethionine binding site [chemical binding]; other site
325240003118	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
325240003119	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
325240003120	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
325240003121	active site
325240003122	Int/Topo IB signature motif; other site
325240003123	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
325240003124	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
325240003125	dimerization domain [polypeptide binding]; other site
325240003126	dimer interface [polypeptide binding]; other site
325240003127	catalytic residues [active]
325240003128	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
325240003129	DHH family; Region: DHH; pfam01368
325240003130	DHHA1 domain; Region: DHHA1; pfam02272
325240003131	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240003132	Coenzyme A binding pocket [chemical binding]; other site
325240003133	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
325240003134	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
325240003135	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
325240003136	catalytic residue [active]
325240003137	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
325240003138	catalytic residues [active]
325240003139	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
325240003140	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
325240003141	peroxiredoxin; Region: AhpC; TIGR03137
325240003142	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
325240003143	dimer interface [polypeptide binding]; other site
325240003144	decamer (pentamer of dimers) interface [polypeptide binding]; other site
325240003145	catalytic triad [active]
325240003146	peroxidatic and resolving cysteines [active]
325240003147	multifunctional aminopeptidase A; Provisional; Region: PRK00913
325240003148	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
325240003149	interface (dimer of trimers) [polypeptide binding]; other site
325240003150	Substrate-binding/catalytic site; other site
325240003151	Zn-binding sites [ion binding]; other site
325240003152	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240003153	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
325240003154	Mechanosensitive ion channel; Region: MS_channel; pfam00924
325240003155	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
325240003156	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
325240003157	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240003158	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240003159	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
325240003160	Domain of unknown function (DU1801); Region: DUF1801; cl17490
325240003161	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
325240003162	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
325240003163	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
325240003164	putative ligand binding site [chemical binding]; other site
325240003165	putative NAD binding site [chemical binding]; other site
325240003166	catalytic site [active]
325240003167	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
325240003168	heme-binding residues [chemical binding]; other site
325240003169	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
325240003170	L-aspartate oxidase; Provisional; Region: PRK06175
325240003171	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240003172	S-adenosylmethionine binding site [chemical binding]; other site
325240003173	Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526
325240003174	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
325240003175	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
325240003176	Transcriptional regulators [Transcription]; Region: MarR; COG1846
325240003177	MarR family; Region: MarR; pfam01047
325240003178	FAD dependent oxidoreductase; Region: DAO; pfam01266
325240003179	23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522
325240003180	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
325240003181	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
325240003182	Chromate transporter; Region: Chromate_transp; pfam02417
325240003183	Cache domain; Region: Cache_2; pfam08269
325240003184	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
325240003185	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240003186	dimerization interface [polypeptide binding]; other site
325240003187	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240003188	dimer interface [polypeptide binding]; other site
325240003189	putative CheW interface [polypeptide binding]; other site
325240003190	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
325240003191	putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814
325240003192	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
325240003193	4Fe-4S binding domain; Region: Fer4_6; pfam12837
325240003194	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
325240003195	4Fe-4S binding domain; Region: Fer4; pfam00037
325240003196	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
325240003197	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
325240003198	[4Fe-4S] binding site [ion binding]; other site
325240003199	molybdopterin cofactor binding site; other site
325240003200	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
325240003201	molybdopterin cofactor binding site; other site
325240003202	peptide chain release factor 2; Validated; Region: prfB; PRK00578
325240003203	This domain is found in peptide chain release factors; Region: PCRF; smart00937
325240003204	RF-1 domain; Region: RF-1; pfam00472
325240003205	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
325240003206	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
325240003207	dimer interface [polypeptide binding]; other site
325240003208	putative anticodon binding site; other site
325240003209	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
325240003210	motif 1; other site
325240003211	active site
325240003212	motif 2; other site
325240003213	motif 3; other site
325240003214	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
325240003215	Carbon starvation protein CstA; Region: CstA; pfam02554
325240003216	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
325240003217	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
325240003218	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
325240003219	dimer interface [polypeptide binding]; other site
325240003220	active site
325240003221	heme binding site [chemical binding]; other site
325240003222	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
325240003223	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
325240003224	CoenzymeA binding site [chemical binding]; other site
325240003225	subunit interaction site [polypeptide binding]; other site
325240003226	PHB binding site; other site
325240003227	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
325240003228	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
325240003229	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
325240003230	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
325240003231	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
325240003232	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
325240003233	tetramer interface [polypeptide binding]; other site
325240003234	active site
325240003235	Mg2+/Mn2+ binding site [ion binding]; other site
325240003236	Protein of unknown function DUF72; Region: DUF72; cl00777
325240003237	PAS domain S-box; Region: sensory_box; TIGR00229
325240003238	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240003239	putative active site [active]
325240003240	heme pocket [chemical binding]; other site
325240003241	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
325240003242	GAF domain; Region: GAF; pfam01590
325240003243	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240003244	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240003245	metal binding site [ion binding]; metal-binding site
325240003246	active site
325240003247	I-site; other site
325240003248	Cache domain; Region: Cache_1; pfam02743
325240003249	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240003250	dimerization interface [polypeptide binding]; other site
325240003251	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
325240003252	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240003253	dimer interface [polypeptide binding]; other site
325240003254	putative CheW interface [polypeptide binding]; other site
325240003255	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
325240003256	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
325240003257	Zn binding site [ion binding]; other site
325240003258	uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722
325240003259	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
325240003260	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
325240003261	active site
325240003262	catalytic residues [active]
325240003263	metal binding site [ion binding]; metal-binding site
325240003264	SlyX; Region: SlyX; pfam04102
325240003265	FOG: WD40 repeat [General function prediction only]; Region: COG2319
325240003266	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
325240003267	structural tetrad; other site
325240003268	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
325240003269	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
325240003270	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
325240003271	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
325240003272	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
325240003273	generic binding surface II; other site
325240003274	generic binding surface I; other site
325240003275	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
325240003276	putative catalytic site [active]
325240003277	putative metal binding site [ion binding]; other site
325240003278	putative phosphate binding site [ion binding]; other site
325240003279	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
325240003280	CoenzymeA binding site [chemical binding]; other site
325240003281	subunit interaction site [polypeptide binding]; other site
325240003282	PHB binding site; other site
325240003283	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
325240003284	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
325240003285	tetramer interface [polypeptide binding]; other site
325240003286	heme binding pocket [chemical binding]; other site
325240003287	NADPH binding site [chemical binding]; other site
325240003288	Predicted membrane protein [Function unknown]; Region: COG2119
325240003289	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
325240003290	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
325240003291	N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211
325240003292	Chitin binding domain; Region: Chitin_bind_3; pfam03067
325240003293	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
325240003294	aromatic amino acid transport protein; Region: araaP; TIGR00837
325240003295	Peptidase S46; Region: Peptidase_S46; pfam10459
325240003296	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
325240003297	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
325240003298	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
325240003299	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240003300	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
325240003301	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
325240003302	ligand binding site [chemical binding]; other site
325240003303	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
325240003304	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
325240003305	RNA binding surface [nucleotide binding]; other site
325240003306	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
325240003307	probable active site [active]
325240003308	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
325240003309	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
325240003310	FMN-binding domain; Region: FMN_bind; pfam04205
325240003311	ApbE family; Region: ApbE; pfam02424
325240003312	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240003313	dimerization interface [polypeptide binding]; other site
325240003314	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
325240003315	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240003316	dimer interface [polypeptide binding]; other site
325240003317	putative CheW interface [polypeptide binding]; other site
325240003318	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
325240003319	EamA-like transporter family; Region: EamA; pfam00892
325240003320	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
325240003321	Helix-turn-helix domain; Region: HTH_18; pfam12833
325240003322	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
325240003323	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240003324	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240003325	Integrase core domain; Region: rve; pfam00665
325240003326	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
325240003327	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
325240003328	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
325240003329	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
325240003330	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
325240003331	DNA-binding site [nucleotide binding]; DNA binding site
325240003332	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
325240003333	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240003334	homodimer interface [polypeptide binding]; other site
325240003335	catalytic residue [active]
325240003336	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
325240003337	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
325240003338	homodimer interface [polypeptide binding]; other site
325240003339	substrate-cofactor binding pocket; other site
325240003340	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240003341	catalytic residue [active]
325240003342	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
325240003343	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
325240003344	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
325240003345	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240003346	S-adenosylmethionine binding site [chemical binding]; other site
325240003347	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
325240003348	BolA-like protein; Region: BolA; cl00386
325240003349	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
325240003350	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
325240003351	S-ribosylhomocysteinase; Provisional; Region: PRK02260
325240003352	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
325240003353	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240003354	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
325240003355	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
325240003356	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
325240003357	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
325240003358	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
325240003359	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
325240003360	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
325240003361	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
325240003362	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
325240003363	FAD binding pocket [chemical binding]; other site
325240003364	FAD binding motif [chemical binding]; other site
325240003365	phosphate binding motif [ion binding]; other site
325240003366	beta-alpha-beta structure motif; other site
325240003367	NAD binding pocket [chemical binding]; other site
325240003368	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
325240003369	ApbE family; Region: ApbE; pfam02424
325240003370	Protein of unknown function (DUF539); Region: DUF539; cl01129
325240003371	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
325240003372	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
325240003373	heme binding site [chemical binding]; other site
325240003374	ferroxidase pore; other site
325240003375	ferroxidase diiron center [ion binding]; other site
325240003376	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
325240003377	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
325240003378	heme binding site [chemical binding]; other site
325240003379	ferroxidase pore; other site
325240003380	ferroxidase diiron center [ion binding]; other site
325240003381	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240003382	dimerization interface [polypeptide binding]; other site
325240003383	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240003384	dimer interface [polypeptide binding]; other site
325240003385	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
325240003386	putative CheW interface [polypeptide binding]; other site
325240003387	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
325240003388	active site
325240003389	DNA polymerase IV; Validated; Region: PRK02406
325240003390	DNA binding site [nucleotide binding]
325240003391	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
325240003392	EamA-like transporter family; Region: EamA; pfam00892
325240003393	EamA-like transporter family; Region: EamA; pfam00892
325240003394	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
325240003395	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
325240003396	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240003397	dimerization interface [polypeptide binding]; other site
325240003398	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240003399	dimer interface [polypeptide binding]; other site
325240003400	putative CheW interface [polypeptide binding]; other site
325240003401	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
325240003402	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
325240003403	metal binding site [ion binding]; metal-binding site
325240003404	dimer interface [polypeptide binding]; other site
325240003405	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
325240003406	interface (dimer of trimers) [polypeptide binding]; other site
325240003407	Substrate-binding/catalytic site; other site
325240003408	Zn-binding sites [ion binding]; other site
325240003409	Protein of unknown function (DUF2956); Region: DUF2956; pfam11169
325240003410	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
325240003411	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
325240003412	Walker A/P-loop; other site
325240003413	ATP binding site [chemical binding]; other site
325240003414	Q-loop/lid; other site
325240003415	ABC transporter signature motif; other site
325240003416	Walker B; other site
325240003417	D-loop; other site
325240003418	H-loop/switch region; other site
325240003419	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
325240003420	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
325240003421	ABC-ATPase subunit  interface; other site
325240003422	dimer interface [polypeptide binding]; other site
325240003423	putative PBP binding regions; other site
325240003424	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
325240003425	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
325240003426	putative hemin binding site; other site
325240003427	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
325240003428	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
325240003429	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
325240003430	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
325240003431	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
325240003432	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
325240003433	N-terminal plug; other site
325240003434	ligand-binding site [chemical binding]; other site
325240003435	Haem utilisation ChuX/HutX; Region: ChuX_HutX; pfam06228
325240003436	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
325240003437	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
325240003438	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
325240003439	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
325240003440	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240003441	Walker A/P-loop; other site
325240003442	ATP binding site [chemical binding]; other site
325240003443	Q-loop/lid; other site
325240003444	ABC transporter signature motif; other site
325240003445	Walker B; other site
325240003446	D-loop; other site
325240003447	H-loop/switch region; other site
325240003448	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677
325240003449	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
325240003450	acyl-activating enzyme (AAE) consensus motif; other site
325240003451	putative AMP binding site [chemical binding]; other site
325240003452	putative active site [active]
325240003453	putative CoA binding site [chemical binding]; other site
325240003454	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
325240003455	4Fe-4S binding domain; Region: Fer4_5; pfam12801
325240003456	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
325240003457	PAS domain S-box; Region: sensory_box; TIGR00229
325240003458	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240003459	putative active site [active]
325240003460	heme pocket [chemical binding]; other site
325240003461	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240003462	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
325240003463	Walker A motif; other site
325240003464	ATP binding site [chemical binding]; other site
325240003465	Walker B motif; other site
325240003466	arginine finger; other site
325240003467	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
325240003468	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
325240003469	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240003470	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240003471	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
325240003472	DsbD alpha interface [polypeptide binding]; other site
325240003473	catalytic residues [active]
325240003474	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
325240003475	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
325240003476	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
325240003477	Protein of unknown function (DUF3144); Region: DUF3144; pfam11342
325240003478	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
325240003479	ligand binding site [chemical binding]; other site
325240003480	active site
325240003481	UGI interface [polypeptide binding]; other site
325240003482	catalytic site [active]
325240003483	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
325240003484	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
325240003485	substrate binding pocket [chemical binding]; other site
325240003486	chain length determination region; other site
325240003487	substrate-Mg2+ binding site; other site
325240003488	catalytic residues [active]
325240003489	aspartate-rich region 1; other site
325240003490	active site lid residues [active]
325240003491	aspartate-rich region 2; other site
325240003492	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
325240003493	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
325240003494	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
325240003495	GTPase CgtA; Reviewed; Region: obgE; PRK12298
325240003496	GTP1/OBG; Region: GTP1_OBG; pfam01018
325240003497	Obg GTPase; Region: Obg; cd01898
325240003498	G1 box; other site
325240003499	GTP/Mg2+ binding site [chemical binding]; other site
325240003500	Switch I region; other site
325240003501	G2 box; other site
325240003502	G3 box; other site
325240003503	Switch II region; other site
325240003504	G4 box; other site
325240003505	G5 box; other site
325240003506	Uncharacterized conserved protein [Function unknown]; Region: COG2966
325240003507	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
325240003508	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
325240003509	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
325240003510	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
325240003511	NADP+ binding site [chemical binding]; other site
325240003512	folate binding site [chemical binding]; other site
325240003513	Protein of unknown function (DUF3718); Region: DUF3718; pfam12514
325240003514	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240003515	dimerization interface [polypeptide binding]; other site
325240003516	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
325240003517	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240003518	dimer interface [polypeptide binding]; other site
325240003519	putative CheW interface [polypeptide binding]; other site
325240003520	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
325240003521	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
325240003522	active site
325240003523	metal binding site [ion binding]; metal-binding site
325240003524	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
325240003525	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
325240003526	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
325240003527	S-adenosylmethionine binding site [chemical binding]; other site
325240003528	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
325240003529	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
325240003530	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
325240003531	SurA N-terminal domain; Region: SurA_N; pfam09312
325240003532	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
325240003533	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
325240003534	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
325240003535	OstA-like protein; Region: OstA; cl00844
325240003536	Organic solvent tolerance protein; Region: OstA_C; pfam04453
325240003537	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
325240003538	Phosphotransferase enzyme family; Region: APH; pfam01636
325240003539	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
325240003540	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
325240003541	Substrate binding site; other site
325240003542	metal-binding site
325240003543	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
325240003544	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
325240003545	putative metal binding site [ion binding]; other site
325240003546	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
325240003547	HSP70 interaction site [polypeptide binding]; other site
325240003548	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
325240003549	glycerate dehydrogenase; Provisional; Region: PRK06487
325240003550	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
325240003551	putative ligand binding site [chemical binding]; other site
325240003552	putative NAD binding site [chemical binding]; other site
325240003553	catalytic site [active]
325240003554	Protein of unknown function (DUF3142); Region: DUF3142; pfam11340
325240003555	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
325240003556	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
325240003557	active site
325240003558	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
325240003559	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
325240003560	ATP-grasp domain; Region: ATP-grasp; pfam02222
325240003561	Protein of unknown function (DUF3302); Region: DUF3302; pfam11742
325240003562	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
325240003563	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
325240003564	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240003565	Ycf46; Provisional; Region: ycf46; CHL00195
325240003566	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240003567	Walker A motif; other site
325240003568	ATP binding site [chemical binding]; other site
325240003569	Walker B motif; other site
325240003570	arginine finger; other site
325240003571	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
325240003572	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
325240003573	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
325240003574	Walker A/P-loop; other site
325240003575	ATP binding site [chemical binding]; other site
325240003576	Q-loop/lid; other site
325240003577	ABC transporter signature motif; other site
325240003578	Walker B; other site
325240003579	D-loop; other site
325240003580	H-loop/switch region; other site
325240003581	TOBE-like domain; Region: TOBE_3; pfam12857
325240003582	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
325240003583	dimer interface [polypeptide binding]; other site
325240003584	conserved gate region; other site
325240003585	putative PBP binding loops; other site
325240003586	ABC-ATPase subunit interface; other site
325240003587	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
325240003588	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
325240003589	dimer interface [polypeptide binding]; other site
325240003590	conserved gate region; other site
325240003591	putative PBP binding loops; other site
325240003592	ABC-ATPase subunit interface; other site
325240003593	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CysP; COG4150
325240003594	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
325240003595	cysteine synthase B; Region: cysM; TIGR01138
325240003596	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
325240003597	dimer interface [polypeptide binding]; other site
325240003598	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240003599	catalytic residue [active]
325240003600	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
325240003601	Predicted Fe-S protein [General function prediction only]; Region: COG3313
325240003602	sensor protein RstB; Provisional; Region: PRK10604
325240003603	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240003604	dimer interface [polypeptide binding]; other site
325240003605	phosphorylation site [posttranslational modification]
325240003606	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240003607	ATP binding site [chemical binding]; other site
325240003608	Mg2+ binding site [ion binding]; other site
325240003609	G-X-G motif; other site
325240003610	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
325240003611	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240003612	active site
325240003613	phosphorylation site [posttranslational modification]
325240003614	intermolecular recognition site; other site
325240003615	dimerization interface [polypeptide binding]; other site
325240003616	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
325240003617	DNA binding site [nucleotide binding]
325240003618	Protein of unknown function (DUF3019); Region: DUF3019; pfam11456
325240003619	MltA-interacting protein MipA; Region: MipA; cl01504
325240003620	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
325240003621	YcxB-like protein; Region: YcxB; pfam14317
325240003622	Domain of unknown function (DUF1971); Region: DUF1971; pfam09313
325240003623	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
325240003624	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
325240003625	active site
325240003626	metal binding site [ion binding]; metal-binding site
325240003627	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
325240003628	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
325240003629	Predicted transcriptional regulator [Transcription]; Region: COG2345
325240003630	Transcriptional regulator PadR-like family; Region: PadR; cl17335
325240003631	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240003632	TPR motif; other site
325240003633	TPR repeat; Region: TPR_11; pfam13414
325240003634	binding surface
325240003635	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
325240003636	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
325240003637	RNA binding surface [nucleotide binding]; other site
325240003638	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
325240003639	active site
325240003640	uracil binding [chemical binding]; other site
325240003641	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
325240003642	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
325240003643	heme-binding site [chemical binding]; other site
325240003644	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
325240003645	FAD binding pocket [chemical binding]; other site
325240003646	FAD binding motif [chemical binding]; other site
325240003647	phosphate binding motif [ion binding]; other site
325240003648	beta-alpha-beta structure motif; other site
325240003649	NAD binding pocket [chemical binding]; other site
325240003650	Heme binding  pocket [chemical binding]; other site
325240003651	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
325240003652	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
325240003653	HAMP domain; Region: HAMP; pfam00672
325240003654	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240003655	dimer interface [polypeptide binding]; other site
325240003656	putative CheW interface [polypeptide binding]; other site
325240003657	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
325240003658	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
325240003659	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
325240003660	RNA binding surface [nucleotide binding]; other site
325240003661	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
325240003662	active site
325240003663	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
325240003664	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
325240003665	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
325240003666	Clp amino terminal domain; Region: Clp_N; pfam02861
325240003667	Clp amino terminal domain; Region: Clp_N; pfam02861
325240003668	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240003669	Walker A motif; other site
325240003670	ATP binding site [chemical binding]; other site
325240003671	Walker B motif; other site
325240003672	arginine finger; other site
325240003673	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240003674	Walker A motif; other site
325240003675	ATP binding site [chemical binding]; other site
325240003676	Walker B motif; other site
325240003677	arginine finger; other site
325240003678	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
325240003679	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
325240003680	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
325240003681	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
325240003682	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240003683	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240003684	Walker A motif; other site
325240003685	ATP binding site [chemical binding]; other site
325240003686	Walker B motif; other site
325240003687	Integrase core domain; Region: rve; pfam00665
325240003688	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
325240003689	oxaloacetate decarboxylase; Provisional; Region: PRK14040
325240003690	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
325240003691	active site
325240003692	catalytic residues [active]
325240003693	metal binding site [ion binding]; metal-binding site
325240003694	homodimer binding site [polypeptide binding]; other site
325240003695	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
325240003696	carboxyltransferase (CT) interaction site; other site
325240003697	biotinylation site [posttranslational modification]; other site
325240003698	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
325240003699	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
325240003700	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
325240003701	Predicted membrane protein [Function unknown]; Region: COG1238
325240003702	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
325240003703	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
325240003704	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
325240003705	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
325240003706	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
325240003707	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
325240003708	glutamate--cysteine ligase; Provisional; Region: PRK02107
325240003709	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
325240003710	N-acetyl-D-glucosamine binding site [chemical binding]; other site
325240003711	catalytic residue [active]
325240003712	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
325240003713	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
325240003714	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240003715	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240003716	metal binding site [ion binding]; metal-binding site
325240003717	active site
325240003718	I-site; other site
325240003719	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
325240003720	ATP-grasp domain; Region: ATP-grasp; pfam02222
325240003721	AIR carboxylase; Region: AIRC; pfam00731
325240003722	putative transporter; Provisional; Region: PRK11660
325240003723	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
325240003724	Sulfate transporter family; Region: Sulfate_transp; pfam00916
325240003725	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
325240003726	von Willebrand factor; Region: vWF_A; pfam12450
325240003727	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
325240003728	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
325240003729	metal ion-dependent adhesion site (MIDAS); other site
325240003730	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
325240003731	RNA polymerase sigma factor; Provisional; Region: PRK12513
325240003732	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
325240003733	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
325240003734	DNA binding residues [nucleotide binding]
325240003735	Hemerythrin-like domain; Region: Hr-like; cd12108
325240003736	Fe binding site [ion binding]; other site
325240003737	Protein of unknown function (DUF3545); Region: DUF3545; pfam12065
325240003738	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
325240003739	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
325240003740	active site
325240003741	dimer interface [polypeptide binding]; other site
325240003742	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
325240003743	dimer interface [polypeptide binding]; other site
325240003744	active site
325240003745	transaldolase-like protein; Provisional; Region: PTZ00411
325240003746	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
325240003747	active site
325240003748	dimer interface [polypeptide binding]; other site
325240003749	catalytic residue [active]
325240003750	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
325240003751	outer membrane protein A; Reviewed; Region: PRK10808
325240003752	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
325240003753	ligand binding site [chemical binding]; other site
325240003754	putative phosphoketolase; Provisional; Region: PRK05261
325240003755	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
325240003756	TPP-binding site; other site
325240003757	XFP C-terminal domain; Region: XFP_C; pfam09363
325240003758	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
325240003759	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
325240003760	hypothetical protein; Validated; Region: PRK02101
325240003761	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
325240003762	PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815
325240003763	PA/protease or protease-like domain interface [polypeptide binding]; other site
325240003764	M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883
325240003765	Peptidase family M28; Region: Peptidase_M28; pfam04389
325240003766	metal binding site [ion binding]; metal-binding site
325240003767	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
325240003768	dimerization interface [polypeptide binding]; other site
325240003769	putative DNA binding site [nucleotide binding]; other site
325240003770	putative Zn2+ binding site [ion binding]; other site
325240003771	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
325240003772	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
325240003773	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
325240003774	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
325240003775	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
325240003776	active site
325240003777	Riboflavin kinase; Region: Flavokinase; smart00904
325240003778	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
325240003779	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
325240003780	HIGH motif; other site
325240003781	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
325240003782	active site
325240003783	KMSKS motif; other site
325240003784	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
325240003785	tRNA binding surface [nucleotide binding]; other site
325240003786	anticodon binding site; other site
325240003787	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
325240003788	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
325240003789	lipoprotein signal peptidase; Provisional; Region: PRK14787
325240003790	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
325240003791	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
325240003792	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
325240003793	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
325240003794	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
325240003795	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
325240003796	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
325240003797	PilX N-terminal; Region: PilX_N; pfam14341
325240003798	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
325240003799	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
325240003800	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
325240003801	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
325240003802	Type II transport protein GspH; Region: GspH; pfam12019
325240003803	Integrase core domain; Region: rve; pfam00665
325240003804	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240003805	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240003806	Walker A motif; other site
325240003807	ATP binding site [chemical binding]; other site
325240003808	Walker B motif; other site
325240003809	Type II transport protein GspH; Region: GspH; pfam12019
325240003810	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
325240003811	Nitrogen regulatory protein P-II; Region: P-II; smart00938
325240003812	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
325240003813	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
325240003814	Transcriptional regulators [Transcription]; Region: PurR; COG1609
325240003815	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
325240003816	DNA binding site [nucleotide binding]
325240003817	domain linker motif; other site
325240003818	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
325240003819	putative ligand binding site [chemical binding]; other site
325240003820	putative dimerization interface [polypeptide binding]; other site
325240003821	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240003822	putative transposase OrfB; Reviewed; Region: PHA02517
325240003823	HTH-like domain; Region: HTH_21; pfam13276
325240003824	Integrase core domain; Region: rve; pfam00665
325240003825	Integrase core domain; Region: rve_2; pfam13333
325240003826	Transposase; Region: HTH_Tnp_1; pfam01527
325240003827	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240003828	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240003829	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240003830	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240003831	Integrase core domain; Region: rve; pfam00665
325240003832	SapC; Region: SapC; pfam07277
325240003833	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
325240003834	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
325240003835	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
325240003836	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
325240003837	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240003838	dimerization interface [polypeptide binding]; other site
325240003839	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
325240003840	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240003841	dimer interface [polypeptide binding]; other site
325240003842	putative CheW interface [polypeptide binding]; other site
325240003843	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
325240003844	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
325240003845	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
325240003846	dimer interface [polypeptide binding]; other site
325240003847	active site
325240003848	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
325240003849	dimer interface [polypeptide binding]; other site
325240003850	active site
325240003851	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
325240003852	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
325240003853	active site
325240003854	dimer interface [polypeptide binding]; other site
325240003855	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
325240003856	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
325240003857	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240003858	putative substrate translocation pore; other site
325240003859	conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001
325240003860	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
325240003861	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
325240003862	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
325240003863	tetrameric interface [polypeptide binding]; other site
325240003864	NAD binding site [chemical binding]; other site
325240003865	catalytic residues [active]
325240003866	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
325240003867	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
325240003868	inhibitor-cofactor binding pocket; inhibition site
325240003869	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240003870	catalytic residue [active]
325240003871	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
325240003872	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
325240003873	NAD(P) binding site [chemical binding]; other site
325240003874	catalytic residues [active]
325240003875	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
325240003876	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240003877	Transposase; Region: HTH_Tnp_1; cl17663
325240003878	Winged helix-turn helix; Region: HTH_29; pfam13551
325240003879	Homeodomain-like domain; Region: HTH_32; pfam13565
325240003880	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
325240003881	Integrase core domain; Region: rve; pfam00665
325240003882	Integrase core domain; Region: rve_3; pfam13683
325240003883	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
325240003884	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
325240003885	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
325240003886	active site residue [active]
325240003887	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
325240003888	active site residue [active]
325240003889	Protein of unknown function (DUF2937); Region: DUF2937; pfam11157
325240003890	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
325240003891	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
325240003892	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
325240003893	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
325240003894	non-specific DNA binding site [nucleotide binding]; other site
325240003895	salt bridge; other site
325240003896	sequence-specific DNA binding site [nucleotide binding]; other site
325240003897	Cupin domain; Region: Cupin_2; pfam07883
325240003898	Peptidase C26; Region: Peptidase_C26; pfam07722
325240003899	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
325240003900	catalytic triad [active]
325240003901	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
325240003902	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
325240003903	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
325240003904	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
325240003905	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
325240003906	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240003907	Walker A/P-loop; other site
325240003908	ATP binding site [chemical binding]; other site
325240003909	Q-loop/lid; other site
325240003910	ABC transporter signature motif; other site
325240003911	Walker B; other site
325240003912	D-loop; other site
325240003913	H-loop/switch region; other site
325240003914	TOBE domain; Region: TOBE_2; pfam08402
325240003915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
325240003916	dimer interface [polypeptide binding]; other site
325240003917	conserved gate region; other site
325240003918	putative PBP binding loops; other site
325240003919	ABC-ATPase subunit interface; other site
325240003920	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
325240003921	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
325240003922	dimer interface [polypeptide binding]; other site
325240003923	conserved gate region; other site
325240003924	putative PBP binding loops; other site
325240003925	ABC-ATPase subunit interface; other site
325240003926	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
325240003927	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
325240003928	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
325240003929	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
325240003930	tetramerization interface [polypeptide binding]; other site
325240003931	NAD(P) binding site [chemical binding]; other site
325240003932	catalytic residues [active]
325240003933	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
325240003934	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
325240003935	inhibitor-cofactor binding pocket; inhibition site
325240003936	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240003937	catalytic residue [active]
325240003938	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
325240003939	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
325240003940	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
325240003941	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240003942	putative substrate translocation pore; other site
325240003943	putative transposase OrfB; Reviewed; Region: PHA02517
325240003944	HTH-like domain; Region: HTH_21; pfam13276
325240003945	Integrase core domain; Region: rve; pfam00665
325240003946	Integrase core domain; Region: rve_2; pfam13333
325240003947	Transposase; Region: HTH_Tnp_1; pfam01527
325240003948	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240003949	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
325240003950	Cupin-like domain; Region: Cupin_8; pfam13621
325240003951	SapC; Region: SapC; pfam07277
325240003952	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
325240003953	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
325240003954	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240003955	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240003956	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240003957	Integrase core domain; Region: rve; pfam00665
325240003958	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240003959	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240003960	Walker A motif; other site
325240003961	ATP binding site [chemical binding]; other site
325240003962	Walker B motif; other site
325240003963	Transcriptional regulators [Transcription]; Region: PurR; COG1609
325240003964	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
325240003965	DNA binding site [nucleotide binding]
325240003966	domain linker motif; other site
325240003967	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
325240003968	dimerization interface (closed form) [polypeptide binding]; other site
325240003969	ligand binding site [chemical binding]; other site
325240003970	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
325240003971	putative symporter YagG; Provisional; Region: PRK09669
325240003972	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
325240003973	beta-galactosidase; Region: BGL; TIGR03356
325240003974	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
325240003975	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240003976	putative substrate translocation pore; other site
325240003977	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
325240003978	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
325240003979	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
325240003980	fructokinase; Reviewed; Region: PRK09557
325240003981	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
325240003982	nucleotide binding site [chemical binding]; other site
325240003983	Acetokinase family; Region: Acetate_kinase; cl17229
325240003984	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
325240003985	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
325240003986	active site
325240003987	DNA binding site [nucleotide binding]
325240003988	Int/Topo IB signature motif; other site
325240003989	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
325240003990	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240003991	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240003992	Walker A motif; other site
325240003993	ATP binding site [chemical binding]; other site
325240003994	Walker B motif; other site
325240003995	Integrase core domain; Region: rve; pfam00665
325240003996	Transposase; Region: HTH_Tnp_1; cl17663
325240003997	Winged helix-turn helix; Region: HTH_29; pfam13551
325240003998	Homeodomain-like domain; Region: HTH_32; pfam13565
325240003999	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
325240004000	Integrase core domain; Region: rve; pfam00665
325240004001	Integrase core domain; Region: rve_3; pfam13683
325240004002	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
325240004003	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
325240004004	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
325240004005	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
325240004006	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
325240004007	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
325240004008	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
325240004009	DNA binding residues [nucleotide binding]
325240004010	DNA primase; Validated; Region: dnaG; PRK05667
325240004011	CHC2 zinc finger; Region: zf-CHC2; pfam01807
325240004012	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
325240004013	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
325240004014	active site
325240004015	metal binding site [ion binding]; metal-binding site
325240004016	interdomain interaction site; other site
325240004017	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
325240004018	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
325240004019	Yqey-like protein; Region: YqeY; pfam09424
325240004020	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
325240004021	UGMP family protein; Validated; Region: PRK09604
325240004022	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
325240004023	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
325240004024	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
325240004025	homooctamer interface [polypeptide binding]; other site
325240004026	active site
325240004027	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
325240004028	catalytic center binding site [active]
325240004029	ATP binding site [chemical binding]; other site
325240004030	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
325240004031	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
325240004032	Methyltransferase domain; Region: Methyltransf_11; pfam08241
325240004033	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
325240004034	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
325240004035	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
325240004036	active site
325240004037	NTP binding site [chemical binding]; other site
325240004038	metal binding triad [ion binding]; metal-binding site
325240004039	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
325240004040	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
325240004041	Zn2+ binding site [ion binding]; other site
325240004042	Mg2+ binding site [ion binding]; other site
325240004043	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
325240004044	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240004045	Walker A motif; other site
325240004046	ATP binding site [chemical binding]; other site
325240004047	Walker B motif; other site
325240004048	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
325240004049	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
325240004050	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
325240004051	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
325240004052	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
325240004053	inhibitor-cofactor binding pocket; inhibition site
325240004054	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240004055	catalytic residue [active]
325240004056	aspartate carbamoyltransferase; Provisional; Region: PRK08192
325240004057	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
325240004058	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
325240004059	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
325240004060	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
325240004061	Cl- selectivity filter; other site
325240004062	Cl- binding residues [ion binding]; other site
325240004063	pore gating glutamate residue; other site
325240004064	dimer interface [polypeptide binding]; other site
325240004065	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
325240004066	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
325240004067	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240004068	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
325240004069	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
325240004070	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
325240004071	amphipathic channel; other site
325240004072	Asn-Pro-Ala signature motifs; other site
325240004073	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
325240004074	putative peptidase; Provisional; Region: PRK11649
325240004075	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
325240004076	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
325240004077	Peptidase family M23; Region: Peptidase_M23; pfam01551
325240004078	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
325240004079	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
325240004080	active site
325240004081	HIGH motif; other site
325240004082	dimer interface [polypeptide binding]; other site
325240004083	KMSKS motif; other site
325240004084	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
325240004085	RNA binding surface [nucleotide binding]; other site
325240004086	SnoaL-like domain; Region: SnoaL_2; pfam12680
325240004087	hypothetical protein; Provisional; Region: PRK10578
325240004088	UPF0126 domain; Region: UPF0126; pfam03458
325240004089	UPF0126 domain; Region: UPF0126; pfam03458
325240004090	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
325240004091	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
325240004092	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
325240004093	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
325240004094	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
325240004095	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
325240004096	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
325240004097	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
325240004098	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
325240004099	active site
325240004100	dimer interface [polypeptide binding]; other site
325240004101	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
325240004102	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
325240004103	active site
325240004104	FMN binding site [chemical binding]; other site
325240004105	substrate binding site [chemical binding]; other site
325240004106	3Fe-4S cluster binding site [ion binding]; other site
325240004107	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
325240004108	domain interface; other site
325240004109	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
325240004110	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
325240004111	FeS/SAM binding site; other site
325240004112	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
325240004113	putative binding surface; other site
325240004114	active site
325240004115	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240004116	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240004117	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
325240004118	dimerization interface [polypeptide binding]; other site
325240004119	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
325240004120	cyclase homology domain; Region: CHD; cd07302
325240004121	nucleotidyl binding site; other site
325240004122	metal binding site [ion binding]; metal-binding site
325240004123	dimer interface [polypeptide binding]; other site
325240004124	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
325240004125	putative DNA-binding cleft [nucleotide binding]; other site
325240004126	putative DNA clevage site; other site
325240004127	molecular lever; other site
325240004128	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
325240004129	putative active site [active]
325240004130	Ap4A binding site [chemical binding]; other site
325240004131	nudix motif; other site
325240004132	putative metal binding site [ion binding]; other site
325240004133	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
325240004134	GAF domain; Region: GAF; pfam01590
325240004135	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
325240004136	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
325240004137	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
325240004138	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
325240004139	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
325240004140	thymidylate synthase; Reviewed; Region: thyA; PRK01827
325240004141	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
325240004142	dimerization interface [polypeptide binding]; other site
325240004143	active site
325240004144	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
325240004145	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
325240004146	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240004147	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
325240004148	dimerization interface [polypeptide binding]; other site
325240004149	Uncharacterized conserved protein [Function unknown]; Region: COG2938
325240004150	L-aspartate oxidase; Provisional; Region: PRK09077
325240004151	L-aspartate oxidase; Provisional; Region: PRK06175
325240004152	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
325240004153	RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923
325240004154	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
325240004155	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
325240004156	DNA binding residues [nucleotide binding]
325240004157	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
325240004158	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
325240004159	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
325240004160	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
325240004161	anti-sigma E factor; Provisional; Region: rseB; PRK09455
325240004162	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
325240004163	GTP-binding protein LepA; Provisional; Region: PRK05433
325240004164	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
325240004165	G1 box; other site
325240004166	putative GEF interaction site [polypeptide binding]; other site
325240004167	GTP/Mg2+ binding site [chemical binding]; other site
325240004168	Switch I region; other site
325240004169	G2 box; other site
325240004170	G3 box; other site
325240004171	Switch II region; other site
325240004172	G4 box; other site
325240004173	G5 box; other site
325240004174	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
325240004175	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
325240004176	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
325240004177	signal peptidase I; Provisional; Region: PRK10861
325240004178	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
325240004179	Catalytic site [active]
325240004180	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
325240004181	ribonuclease III; Reviewed; Region: rnc; PRK00102
325240004182	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
325240004183	dimerization interface [polypeptide binding]; other site
325240004184	active site
325240004185	metal binding site [ion binding]; metal-binding site
325240004186	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
325240004187	dsRNA binding site [nucleotide binding]; other site
325240004188	GTPase Era; Reviewed; Region: era; PRK00089
325240004189	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
325240004190	G1 box; other site
325240004191	GTP/Mg2+ binding site [chemical binding]; other site
325240004192	Switch I region; other site
325240004193	G2 box; other site
325240004194	Switch II region; other site
325240004195	G3 box; other site
325240004196	G4 box; other site
325240004197	G5 box; other site
325240004198	KH domain; Region: KH_2; pfam07650
325240004199	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
325240004200	Recombination protein O N terminal; Region: RecO_N; pfam11967
325240004201	Recombination protein O C terminal; Region: RecO_C; pfam02565
325240004202	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
325240004203	active site
325240004204	hydrophilic channel; other site
325240004205	dimerization interface [polypeptide binding]; other site
325240004206	catalytic residues [active]
325240004207	active site lid [active]
325240004208	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
325240004209	Protein of unknown function (DUF962); Region: DUF962; cl01879
325240004210	Domain of unknown function DUF21; Region: DUF21; pfam01595
325240004211	hypothetical protein; Provisional; Region: PRK11573
325240004212	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
325240004213	Transporter associated domain; Region: CorC_HlyC; smart01091
325240004214	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
325240004215	signal recognition particle protein; Provisional; Region: PRK10867
325240004216	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
325240004217	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
325240004218	P loop; other site
325240004219	GTP binding site [chemical binding]; other site
325240004220	Signal peptide binding domain; Region: SRP_SPB; pfam02978
325240004221	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
325240004222	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
325240004223	RimM N-terminal domain; Region: RimM; pfam01782
325240004224	PRC-barrel domain; Region: PRC; pfam05239
325240004225	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
325240004226	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
325240004227	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
325240004228	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
325240004229	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
325240004230	chorismate mutase domain of T-protein; Region: CM_T; TIGR01799
325240004231	prephenate dehydrogenase; Validated; Region: PRK08507
325240004232	hybrid cluster protein; Provisional; Region: PRK05290
325240004233	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
325240004234	ACS interaction site; other site
325240004235	CODH interaction site; other site
325240004236	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
325240004237	hybrid metal cluster; other site
325240004238	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
325240004239	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
325240004240	FAD binding pocket [chemical binding]; other site
325240004241	FAD binding motif [chemical binding]; other site
325240004242	phosphate binding motif [ion binding]; other site
325240004243	beta-alpha-beta structure motif; other site
325240004244	NAD binding pocket [chemical binding]; other site
325240004245	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
325240004246	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
325240004247	catalytic loop [active]
325240004248	iron binding site [ion binding]; other site
325240004249	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
325240004250	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
325240004251	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
325240004252	Prephenate dehydratase; Region: PDT; pfam00800
325240004253	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
325240004254	putative L-Phe binding site [chemical binding]; other site
325240004255	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
325240004256	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
325240004257	30S subunit binding site; other site
325240004258	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
325240004259	Cytochrome C' Region: Cytochrom_C_2; pfam01322
325240004260	Trp repressor protein; Region: Trp_repressor; pfam01371
325240004261	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
325240004262	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
325240004263	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
325240004264	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
325240004265	putative catalytic residues [active]
325240004266	putative nucleotide binding site [chemical binding]; other site
325240004267	putative aspartate binding site [chemical binding]; other site
325240004268	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
325240004269	dimer interface [polypeptide binding]; other site
325240004270	putative threonine allosteric regulatory site; other site
325240004271	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
325240004272	putative threonine allosteric regulatory site; other site
325240004273	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
325240004274	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
325240004275	homoserine kinase; Provisional; Region: PRK01212
325240004276	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
325240004277	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
325240004278	threonine synthase; Validated; Region: PRK09225
325240004279	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
325240004280	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
325240004281	catalytic residue [active]
325240004282	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
325240004283	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
325240004284	substrate binding pocket [chemical binding]; other site
325240004285	membrane-bound complex binding site; other site
325240004286	hinge residues; other site
325240004287	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
325240004288	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
325240004289	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
325240004290	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
325240004291	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
325240004292	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
325240004293	protein binding site [polypeptide binding]; other site
325240004294	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
325240004295	Domain interface; other site
325240004296	Peptide binding site; other site
325240004297	Active site tetrad [active]
325240004298	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
325240004299	OsmC-like protein; Region: OsmC; cl00767
325240004300	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
325240004301	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
325240004302	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
325240004303	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
325240004304	PAS domain; Region: PAS_9; pfam13426
325240004305	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240004306	putative active site [active]
325240004307	heme pocket [chemical binding]; other site
325240004308	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
325240004309	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240004310	dimer interface [polypeptide binding]; other site
325240004311	putative CheW interface [polypeptide binding]; other site
325240004312	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
325240004313	30S subunit binding site; other site
325240004314	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
325240004315	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240004316	active site
325240004317	phosphorylation site [posttranslational modification]
325240004318	intermolecular recognition site; other site
325240004319	dimerization interface [polypeptide binding]; other site
325240004320	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
325240004321	dimerization interface [polypeptide binding]; other site
325240004322	DNA binding residues [nucleotide binding]
325240004323	Histidine kinase; Region: HisKA_3; pfam07730
325240004324	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
325240004325	Mg2+ binding site [ion binding]; other site
325240004326	G-X-G motif; other site
325240004327	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
325240004328	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
325240004329	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
325240004330	hypothetical protein; Provisional; Region: PRK12378
325240004331	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
325240004332	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240004333	dimer interface [polypeptide binding]; other site
325240004334	putative CheW interface [polypeptide binding]; other site
325240004335	Protein of unknown function (DUF2375); Region: DUF2375; pfam09558
325240004336	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
325240004337	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
325240004338	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
325240004339	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
325240004340	FMN binding site [chemical binding]; other site
325240004341	active site
325240004342	substrate binding site [chemical binding]; other site
325240004343	catalytic residue [active]
325240004344	AAA domain; Region: AAA_32; pfam13654
325240004345	ATP-dependent protease Lon; Provisional; Region: PRK13765
325240004346	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
325240004347	PAS fold; Region: PAS; pfam00989
325240004348	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240004349	PAS domain; Region: PAS_9; pfam13426
325240004350	putative active site [active]
325240004351	heme pocket [chemical binding]; other site
325240004352	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240004353	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240004354	metal binding site [ion binding]; metal-binding site
325240004355	active site
325240004356	I-site; other site
325240004357	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240004358	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
325240004359	DEAD-like helicases superfamily; Region: DEXDc; smart00487
325240004360	ATP binding site [chemical binding]; other site
325240004361	Mg++ binding site [ion binding]; other site
325240004362	motif III; other site
325240004363	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240004364	nucleotide binding region [chemical binding]; other site
325240004365	ATP-binding site [chemical binding]; other site
325240004366	Helix-turn-helix domain; Region: HTH_28; pfam13518
325240004367	Winged helix-turn helix; Region: HTH_29; pfam13551
325240004368	Homeodomain-like domain; Region: HTH_32; pfam13565
325240004369	Integrase core domain; Region: rve; pfam00665
325240004370	DDE domain; Region: DDE_Tnp_IS240; pfam13610
325240004371	Integrase core domain; Region: rve_3; pfam13683
325240004372	Integrase core domain; Region: rve; pfam00665
325240004373	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240004374	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240004375	Walker A motif; other site
325240004376	ATP binding site [chemical binding]; other site
325240004377	Walker B motif; other site
325240004378	Transposase; Region: HTH_Tnp_1; cl17663
325240004379	Winged helix-turn helix; Region: HTH_29; pfam13551
325240004380	Homeodomain-like domain; Region: HTH_32; pfam13565
325240004381	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
325240004382	Integrase core domain; Region: rve; pfam00665
325240004383	Integrase core domain; Region: rve_3; pfam13683
325240004384	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
325240004385	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
325240004386	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
325240004387	non-specific DNA binding site [nucleotide binding]; other site
325240004388	salt bridge; other site
325240004389	sequence-specific DNA binding site [nucleotide binding]; other site
325240004390	Winged helix-turn helix; Region: HTH_29; pfam13551
325240004391	Homeodomain-like domain; Region: HTH_32; pfam13565
325240004392	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
325240004393	Integrase core domain; Region: rve; pfam00665
325240004394	Integrase core domain; Region: rve_3; pfam13683
325240004395	Transposase; Region: HTH_Tnp_1; cl17663
325240004396	This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901
325240004397	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240004398	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240004399	Integrase core domain; Region: rve; pfam00665
325240004400	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240004401	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240004402	Integrase core domain; Region: rve; pfam00665
325240004403	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
325240004404	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
325240004405	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
325240004406	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
325240004407	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
325240004408	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
325240004409	Phage-related protein [Function unknown]; Region: COG4695; cl01923
325240004410	Phage portal protein; Region: Phage_portal; pfam04860
325240004411	terminase ATPase subunit; Provisional; Region: P; PHA02535
325240004412	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
325240004413	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
325240004414	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
325240004415	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
325240004416	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
325240004417	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
325240004418	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
325240004419	Protein of unknown function (DUF2586); Region: DUF2586; pfam10758
325240004420	Protein of unknown function (DUF2597); Region: DUF2597; pfam10772
325240004421	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
325240004422	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
325240004423	catalytic residues [active]
325240004424	Protein of unknown function (DUF2765); Region: DUF2765; pfam10963
325240004425	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
325240004426	Protein of unknown function (DUF2590); Region: DUF2590; pfam10761
325240004427	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
325240004428	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
325240004429	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
325240004430	SmpB-tmRNA interface; other site
325240004431	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
325240004432	putative coenzyme Q binding site [chemical binding]; other site
325240004433	RnfH family Ubiquitin; Region: Ub-RnfH; cl17382
325240004434	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
325240004435	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
325240004436	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
325240004437	active site
325240004438	SAM binding site [chemical binding]; other site
325240004439	homodimer interface [polypeptide binding]; other site
325240004440	Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673
325240004441	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240004442	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240004443	metal binding site [ion binding]; metal-binding site
325240004444	active site
325240004445	I-site; other site
325240004446	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
325240004447	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
325240004448	TrkA-N domain; Region: TrkA_N; pfam02254
325240004449	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
325240004450	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240004451	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240004452	malate synthase A; Region: malate_syn_A; TIGR01344
325240004453	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
325240004454	active site
325240004455	isocitrate lyase; Provisional; Region: PRK15063
325240004456	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
325240004457	tetramer interface [polypeptide binding]; other site
325240004458	active site
325240004459	Mg2+/Mn2+ binding site [ion binding]; other site
325240004460	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
325240004461	putative alcohol dehydrogenase; Provisional; Region: PRK09860
325240004462	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
325240004463	dimer interface [polypeptide binding]; other site
325240004464	active site
325240004465	metal binding site [ion binding]; metal-binding site
325240004466	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240004467	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240004468	Integrase core domain; Region: rve; pfam00665
325240004469	transcriptional regulator BetI; Validated; Region: PRK00767
325240004470	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
325240004471	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
325240004472	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
325240004473	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
325240004474	NAD(P) binding site [chemical binding]; other site
325240004475	catalytic residues [active]
325240004476	choline dehydrogenase; Validated; Region: PRK02106
325240004477	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
325240004478	BCCT family transporter; Region: BCCT; cl00569
325240004479	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
325240004480	Transcriptional regulators [Transcription]; Region: MarR; COG1846
325240004481	MarR family; Region: MarR; pfam01047
325240004482	MarR family; Region: MarR_2; cl17246
325240004483	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
325240004484	active site
325240004485	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
325240004486	glycogen branching enzyme; Provisional; Region: PRK05402
325240004487	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
325240004488	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
325240004489	active site
325240004490	catalytic site [active]
325240004491	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
325240004492	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
325240004493	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
325240004494	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
325240004495	active site
325240004496	catalytic site [active]
325240004497	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
325240004498	homodimer interface [polypeptide binding]; other site
325240004499	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
325240004500	active site pocket [active]
325240004501	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
325240004502	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
325240004503	ligand binding site; other site
325240004504	oligomer interface; other site
325240004505	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
325240004506	dimer interface [polypeptide binding]; other site
325240004507	N-terminal domain interface [polypeptide binding]; other site
325240004508	sulfate 1 binding site; other site
325240004509	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
325240004510	glycogen synthase; Provisional; Region: glgA; PRK00654
325240004511	ADP-binding pocket [chemical binding]; other site
325240004512	homodimer interface [polypeptide binding]; other site
325240004513	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
325240004514	PAS domain S-box; Region: sensory_box; TIGR00229
325240004515	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240004516	putative active site [active]
325240004517	heme pocket [chemical binding]; other site
325240004518	PAS fold; Region: PAS_3; pfam08447
325240004519	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240004520	PAS domain; Region: PAS_9; pfam13426
325240004521	putative active site [active]
325240004522	heme pocket [chemical binding]; other site
325240004523	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240004524	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240004525	metal binding site [ion binding]; metal-binding site
325240004526	active site
325240004527	I-site; other site
325240004528	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240004529	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
325240004530	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
325240004531	ATP binding site [chemical binding]; other site
325240004532	Mg++ binding site [ion binding]; other site
325240004533	motif III; other site
325240004534	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240004535	nucleotide binding region [chemical binding]; other site
325240004536	ATP-binding site [chemical binding]; other site
325240004537	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
325240004538	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
325240004539	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
325240004540	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
325240004541	substrate binding pocket [chemical binding]; other site
325240004542	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
325240004543	membrane-bound complex binding site; other site
325240004544	hinge residues; other site
325240004545	Protein of unknown function (DUF3087); Region: DUF3087; pfam11286
325240004546	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240004547	Major Facilitator Superfamily; Region: MFS_1; pfam07690
325240004548	putative substrate translocation pore; other site
325240004549	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
325240004550	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
325240004551	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
325240004552	dimer interface [polypeptide binding]; other site
325240004553	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
325240004554	ligand binding site [chemical binding]; other site
325240004555	BCS1 N terminal; Region: BCS1_N; cl07381
325240004556	ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004
325240004557	putative transposase OrfB; Reviewed; Region: PHA02517
325240004558	HTH-like domain; Region: HTH_21; pfam13276
325240004559	Integrase core domain; Region: rve; pfam00665
325240004560	Integrase core domain; Region: rve_3; pfam13683
325240004561	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240004562	Transposase; Region: HTH_Tnp_1; pfam01527
325240004563	BCS1 N terminal; Region: BCS1_N; cl07381
325240004564	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
325240004565	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
325240004566	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
325240004567	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
325240004568	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
325240004569	Cysteine-rich domain; Region: CCG; pfam02754
325240004570	Cysteine-rich domain; Region: CCG; pfam02754
325240004571	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
325240004572	FAD binding domain; Region: FAD_binding_4; pfam01565
325240004573	4Fe-4S binding domain; Region: Fer4; pfam00037
325240004574	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
325240004575	L-lactate permease; Region: Lactate_perm; cl00701
325240004576	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
325240004577	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
325240004578	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
325240004579	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
325240004580	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
325240004581	dimer interface [polypeptide binding]; other site
325240004582	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
325240004583	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
325240004584	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
325240004585	TPP-binding site; other site
325240004586	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
325240004587	PYR/PP interface [polypeptide binding]; other site
325240004588	dimer interface [polypeptide binding]; other site
325240004589	TPP binding site [chemical binding]; other site
325240004590	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
325240004591	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
325240004592	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
325240004593	substrate binding pocket [chemical binding]; other site
325240004594	chain length determination region; other site
325240004595	substrate-Mg2+ binding site; other site
325240004596	catalytic residues [active]
325240004597	aspartate-rich region 1; other site
325240004598	active site lid residues [active]
325240004599	aspartate-rich region 2; other site
325240004600	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
325240004601	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
325240004602	flagellar motor protein PomA; Reviewed; Region: PRK08990
325240004603	flagellar motor protein MotB; Reviewed; Region: motB; PRK08944
325240004604	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
325240004605	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
325240004606	ligand binding site [chemical binding]; other site
325240004607	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
325240004608	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
325240004609	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
325240004610	Ligand Binding Site [chemical binding]; other site
325240004611	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
325240004612	active site residue [active]
325240004613	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
325240004614	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240004615	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
325240004616	dimerization interface [polypeptide binding]; other site
325240004617	substrate binding pocket [chemical binding]; other site
325240004618	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
325240004619	Protein of unknown function (DUF423); Region: DUF423; pfam04241
325240004620	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
325240004621	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
325240004622	isocitrate dehydrogenase; Provisional; Region: PRK08997
325240004623	tartrate dehydrogenase; Region: TTC; TIGR02089
325240004624	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
325240004625	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
325240004626	Protein of unknown function (DUF3192); Region: DUF3192; pfam11399
325240004627	flap endonuclease-like protein; Provisional; Region: PRK09482
325240004628	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
325240004629	active site
325240004630	metal binding site 1 [ion binding]; metal-binding site
325240004631	putative 5' ssDNA interaction site; other site
325240004632	metal binding site 3; metal-binding site
325240004633	metal binding site 2 [ion binding]; metal-binding site
325240004634	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
325240004635	putative DNA binding site [nucleotide binding]; other site
325240004636	putative metal binding site [ion binding]; other site
325240004637	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
325240004638	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
325240004639	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240004640	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240004641	metal binding site [ion binding]; metal-binding site
325240004642	active site
325240004643	I-site; other site
325240004644	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240004645	TPR motif; other site
325240004646	binding surface
325240004647	Tetratricopeptide repeat; Region: TPR_12; pfam13424
325240004648	Tetratricopeptide repeat; Region: TPR_12; pfam13424
325240004649	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
325240004650	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
325240004651	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
325240004652	protein binding site [polypeptide binding]; other site
325240004653	recombination associated protein; Reviewed; Region: rdgC; PRK00321
325240004654	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
325240004655	trimer interface [polypeptide binding]; other site
325240004656	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
325240004657	eyelet of channel; other site
325240004658	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
325240004659	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240004660	active site
325240004661	phosphorylation site [posttranslational modification]
325240004662	intermolecular recognition site; other site
325240004663	dimerization interface [polypeptide binding]; other site
325240004664	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
325240004665	DNA binding site [nucleotide binding]
325240004666	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
325240004667	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
325240004668	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240004669	putative active site [active]
325240004670	heme pocket [chemical binding]; other site
325240004671	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240004672	dimer interface [polypeptide binding]; other site
325240004673	phosphorylation site [posttranslational modification]
325240004674	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240004675	ATP binding site [chemical binding]; other site
325240004676	Mg2+ binding site [ion binding]; other site
325240004677	G-X-G motif; other site
325240004678	PBP superfamily domain; Region: PBP_like_2; cl17296
325240004679	Integrase core domain; Region: rve; pfam00665
325240004680	Integrase core domain; Region: rve_3; pfam13683
325240004681	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240004682	leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411
325240004683	Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599
325240004684	active site
325240004685	Zn binding site [ion binding]; other site
325240004686	Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127
325240004687	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
325240004688	catalytic residues [active]
325240004689	dimer interface [polypeptide binding]; other site
325240004690	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
325240004691	MgtE intracellular N domain; Region: MgtE_N; smart00924
325240004692	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
325240004693	Divalent cation transporter; Region: MgtE; cl00786
325240004694	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
325240004695	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240004696	Coenzyme A binding pocket [chemical binding]; other site
325240004697	YfaZ precursor; Region: YfaZ; pfam07437
325240004698	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
325240004699	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
325240004700	EamA-like transporter family; Region: EamA; pfam00892
325240004701	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
325240004702	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
325240004703	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240004704	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240004705	metal binding site [ion binding]; metal-binding site
325240004706	active site
325240004707	I-site; other site
325240004708	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
325240004709	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
325240004710	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
325240004711	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240004712	S-adenosylmethionine binding site [chemical binding]; other site
325240004713	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
325240004714	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
325240004715	C-terminal domain interface [polypeptide binding]; other site
325240004716	GSH binding site (G-site) [chemical binding]; other site
325240004717	dimer interface [polypeptide binding]; other site
325240004718	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
325240004719	N-terminal domain interface [polypeptide binding]; other site
325240004720	putative dimer interface [polypeptide binding]; other site
325240004721	active site
325240004722	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
325240004723	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
325240004724	putative C-terminal domain interface [polypeptide binding]; other site
325240004725	putative GSH binding site (G-site) [chemical binding]; other site
325240004726	putative dimer interface [polypeptide binding]; other site
325240004727	C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182
325240004728	putative N-terminal domain interface [polypeptide binding]; other site
325240004729	putative dimer interface [polypeptide binding]; other site
325240004730	putative substrate binding pocket (H-site) [chemical binding]; other site
325240004731	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
325240004732	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
325240004733	TIGR02453 family protein; Region: TIGR02453
325240004734	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
325240004735	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
325240004736	N-terminal plug; other site
325240004737	ligand-binding site [chemical binding]; other site
325240004738	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782
325240004739	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
325240004740	PhnA protein; Region: PhnA; pfam03831
325240004741	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
325240004742	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240004743	putative substrate translocation pore; other site
325240004744	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
325240004745	MarR family; Region: MarR; pfam01047
325240004746	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
325240004747	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
325240004748	putative active site [active]
325240004749	Zn binding site [ion binding]; other site
325240004750	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240004751	dimerization interface [polypeptide binding]; other site
325240004752	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
325240004753	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240004754	dimer interface [polypeptide binding]; other site
325240004755	putative CheW interface [polypeptide binding]; other site
325240004756	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
325240004757	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
325240004758	Putative carbohydrate binding domain; Region: CHB_HEX; smart01081
325240004759	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
325240004760	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
325240004761	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
325240004762	active site
325240004763	C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847
325240004764	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
325240004765	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
325240004766	nucleotide binding site [chemical binding]; other site
325240004767	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
325240004768	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240004769	putative substrate translocation pore; other site
325240004770	L-fucose transporter; Provisional; Region: PRK10133; cl17665
325240004771	Helix-turn-helix domain; Region: HTH_18; pfam12833
325240004772	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
325240004773	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
325240004774	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240004775	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
325240004776	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
325240004777	Putative catalytic NodB homology domain of uncharacterized Mll8295 protein encoded from Rhizobium loti and its bacterial homologs; Region: CE4_Mll8295_like; cd10946
325240004778	NodB motif; other site
325240004779	putative active site [active]
325240004780	putative catalytic site [active]
325240004781	putative Zn binding site [ion binding]; other site
325240004782	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
325240004783	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
325240004784	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
325240004785	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240004786	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
325240004787	BON domain; Region: BON; pfam04972
325240004788	BON domain; Region: BON; pfam04972
325240004789	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
325240004790	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240004791	Walker A motif; other site
325240004792	ATP binding site [chemical binding]; other site
325240004793	Walker B motif; other site
325240004794	arginine finger; other site
325240004795	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
325240004796	Major royal jelly protein; Region: MRJP; pfam03022
325240004797	hypothetical protein; Provisional; Region: PRK12361
325240004798	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
325240004799	active site
325240004800	catalytic residues [active]
325240004801	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
325240004802	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
325240004803	FMN binding site [chemical binding]; other site
325240004804	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
325240004805	substrate binding site [chemical binding]; other site
325240004806	putative catalytic residue [active]
325240004807	3-oxoacyl-[acyl-carrier-protein] synthase; Region: PLN02836
325240004808	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
325240004809	active site
325240004810	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
325240004811	active site
325240004812	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
325240004813	active site 2 [active]
325240004814	dimer interface [polypeptide binding]; other site
325240004815	active site 1 [active]
325240004816	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
325240004817	active site 1 [active]
325240004818	dimer interface [polypeptide binding]; other site
325240004819	active site 2 [active]
325240004820	Acyl transferase domain; Region: Acyl_transf_1; cl08282
325240004821	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
325240004822	3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050
325240004823	active site
325240004824	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
325240004825	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
325240004826	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
325240004827	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
325240004828	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
325240004829	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
325240004830	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
325240004831	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
325240004832	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
325240004833	putative NADP binding site [chemical binding]; other site
325240004834	active site
325240004835	Winged helix-turn helix; Region: HTH_29; pfam13551
325240004836	Helix-turn-helix domain; Region: HTH_17; pfam12728
325240004837	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
325240004838	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
325240004839	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
325240004840	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
325240004841	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
325240004842	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240004843	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
325240004844	putative substrate binding pocket [chemical binding]; other site
325240004845	putative dimerization interface [polypeptide binding]; other site
325240004846	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
325240004847	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
325240004848	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
325240004849	SecY interacting protein Syd; Provisional; Region: PRK04968
325240004850	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; pfam10071
325240004851	Protein of unknown function (DUF3192); Region: DUF3192; pfam11399
325240004852	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
325240004853	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
325240004854	Coenzyme A binding pocket [chemical binding]; other site
325240004855	Protein of unknown function (DUF962); Region: DUF962; pfam06127
325240004856	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
325240004857	Protein of unknown function (DUF3549); Region: DUF3549; pfam12069
325240004858	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
325240004859	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
325240004860	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
325240004861	probable active site [active]
325240004862	flavodoxin; Provisional; Region: PRK08105
325240004863	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
325240004864	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
325240004865	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
325240004866	active site turn [active]
325240004867	phosphorylation site [posttranslational modification]
325240004868	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
325240004869	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
325240004870	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
325240004871	putative active site [active]
325240004872	putative substrate binding site [chemical binding]; other site
325240004873	putative cosubstrate binding site; other site
325240004874	catalytic site [active]
325240004875	PAS domain; Region: PAS_9; pfam13426
325240004876	GAF domain; Region: GAF_2; pfam13185
325240004877	GAF domain; Region: GAF; pfam01590
325240004878	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
325240004879	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
325240004880	Zn2+ binding site [ion binding]; other site
325240004881	Mg2+ binding site [ion binding]; other site
325240004882	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
325240004883	FOG: CBS domain [General function prediction only]; Region: COG0517
325240004884	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
325240004885	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
325240004886	trimer interface [polypeptide binding]; other site
325240004887	active site
325240004888	substrate binding site [chemical binding]; other site
325240004889	CoA binding site [chemical binding]; other site
325240004890	PII uridylyl-transferase; Provisional; Region: PRK05007
325240004891	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
325240004892	metal binding triad; other site
325240004893	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
325240004894	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
325240004895	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
325240004896	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
325240004897	active site
325240004898	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
325240004899	rRNA interaction site [nucleotide binding]; other site
325240004900	S8 interaction site; other site
325240004901	putative laminin-1 binding site; other site
325240004902	elongation factor Ts; Provisional; Region: tsf; PRK09377
325240004903	UBA/TS-N domain; Region: UBA; pfam00627
325240004904	Elongation factor TS; Region: EF_TS; pfam00889
325240004905	Elongation factor TS; Region: EF_TS; pfam00889
325240004906	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
325240004907	putative nucleotide binding site [chemical binding]; other site
325240004908	uridine monophosphate binding site [chemical binding]; other site
325240004909	homohexameric interface [polypeptide binding]; other site
325240004910	ribosome recycling factor; Reviewed; Region: frr; PRK00083
325240004911	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
325240004912	hinge region; other site
325240004913	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
325240004914	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
325240004915	catalytic residue [active]
325240004916	putative FPP diphosphate  binding site; other site
325240004917	putative FPP binding hydrophobic cleft; other site
325240004918	dimer interface [polypeptide binding]; other site
325240004919	putative IPP diphosphate binding site; other site
325240004920	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
325240004921	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
325240004922	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
325240004923	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
325240004924	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
325240004925	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
325240004926	zinc metallopeptidase RseP; Provisional; Region: PRK10779
325240004927	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
325240004928	active site
325240004929	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
325240004930	protein binding site [polypeptide binding]; other site
325240004931	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
325240004932	protein binding site [polypeptide binding]; other site
325240004933	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
325240004934	putative substrate binding region [chemical binding]; other site
325240004935	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
325240004936	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
325240004937	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
325240004938	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
325240004939	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
325240004940	Surface antigen; Region: Bac_surface_Ag; pfam01103
325240004941	periplasmic chaperone; Provisional; Region: PRK10780
325240004942	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
325240004943	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
325240004944	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
325240004945	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
325240004946	trimer interface [polypeptide binding]; other site
325240004947	active site
325240004948	UDP-GlcNAc binding site [chemical binding]; other site
325240004949	lipid binding site [chemical binding]; lipid-binding site
325240004950	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
325240004951	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
325240004952	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
325240004953	active site
325240004954	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
325240004955	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
325240004956	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
325240004957	RNA/DNA hybrid binding site [nucleotide binding]; other site
325240004958	active site
325240004959	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
325240004960	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
325240004961	putative active site [active]
325240004962	putative PHP Thumb interface [polypeptide binding]; other site
325240004963	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
325240004964	generic binding surface II; other site
325240004965	generic binding surface I; other site
325240004966	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
325240004967	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
325240004968	Ligand Binding Site [chemical binding]; other site
325240004969	TilS substrate binding domain; Region: TilS; pfam09179
325240004970	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
325240004971	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240004972	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240004973	metal binding site [ion binding]; metal-binding site
325240004974	active site
325240004975	I-site; other site
325240004976	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
325240004977	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
325240004978	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
325240004979	TrkA-N domain; Region: TrkA_N; pfam02254
325240004980	TrkA-C domain; Region: TrkA_C; pfam02080
325240004981	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
325240004982	DNA-binding site [nucleotide binding]; DNA binding site
325240004983	RNA-binding motif; other site
325240004984	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
325240004985	SWIM zinc finger; Region: SWIM; pfam04434
325240004986	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
325240004987	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
325240004988	ATP binding site [chemical binding]; other site
325240004989	putative Mg++ binding site [ion binding]; other site
325240004990	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240004991	nucleotide binding region [chemical binding]; other site
325240004992	ATP-binding site [chemical binding]; other site
325240004993	putative hydrolase; Validated; Region: PRK09248
325240004994	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
325240004995	active site
325240004996	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
325240004997	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
325240004998	NADP binding site [chemical binding]; other site
325240004999	active site
325240005000	putative substrate binding site [chemical binding]; other site
325240005001	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
325240005002	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
325240005003	active site
325240005004	fructokinase; Reviewed; Region: PRK09557
325240005005	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
325240005006	nucleotide binding site [chemical binding]; other site
325240005007	Uncharacterized conserved protein [Function unknown]; Region: COG1434
325240005008	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
325240005009	putative active site [active]
325240005010	Protein of unknown function (DUF2982); Region: DUF2982; pfam11201
325240005011	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
325240005012	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240005013	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240005014	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
325240005015	dimerization interface [polypeptide binding]; other site
325240005016	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
325240005017	ferredoxin-type protein; Provisional; Region: PRK10194
325240005018	4Fe-4S binding domain; Region: Fer4; cl02805
325240005019	UDP-glucose 4-epimerase; Region: PLN02240
325240005020	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
325240005021	NAD binding site [chemical binding]; other site
325240005022	homodimer interface [polypeptide binding]; other site
325240005023	active site
325240005024	substrate binding site [chemical binding]; other site
325240005025	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
325240005026	active site
325240005027	tetramer interface; other site
325240005028	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
325240005029	cofactor binding site; other site
325240005030	metal binding site [ion binding]; metal-binding site
325240005031	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
325240005032	aromatic arch; other site
325240005033	DCoH dimer interaction site [polypeptide binding]; other site
325240005034	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
325240005035	DCoH tetramer interaction site [polypeptide binding]; other site
325240005036	substrate binding site [chemical binding]; other site
325240005037	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
325240005038	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
325240005039	putative aromatic amino acid binding site; other site
325240005040	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240005041	Walker A motif; other site
325240005042	ATP binding site [chemical binding]; other site
325240005043	Walker B motif; other site
325240005044	arginine finger; other site
325240005045	GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508
325240005046	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
325240005047	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
325240005048	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
325240005049	maleylacetoacetate isomerase; Region: maiA; TIGR01262
325240005050	C-terminal domain interface [polypeptide binding]; other site
325240005051	GSH binding site (G-site) [chemical binding]; other site
325240005052	putative dimer interface [polypeptide binding]; other site
325240005053	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
325240005054	dimer interface [polypeptide binding]; other site
325240005055	N-terminal domain interface [polypeptide binding]; other site
325240005056	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
325240005057	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
325240005058	outer membrane protein W; Provisional; Region: PRK10959
325240005059	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
325240005060	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
325240005061	NAD(P) binding site [chemical binding]; other site
325240005062	active site
325240005063	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
325240005064	homoserine O-succinyltransferase; Provisional; Region: PRK05368
325240005065	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
325240005066	proposed active site lysine [active]
325240005067	conserved cys residue [active]
325240005068	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
325240005069	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
325240005070	HAMP domain; Region: HAMP; pfam00672
325240005071	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240005072	dimer interface [polypeptide binding]; other site
325240005073	putative CheW interface [polypeptide binding]; other site
325240005074	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
325240005075	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
325240005076	dimer interface [polypeptide binding]; other site
325240005077	active site
325240005078	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
325240005079	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
325240005080	tetrameric interface [polypeptide binding]; other site
325240005081	NAD binding site [chemical binding]; other site
325240005082	catalytic residues [active]
325240005083	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
325240005084	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
325240005085	active site
325240005086	enoyl-CoA hydratase; Provisional; Region: PRK09076
325240005087	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
325240005088	substrate binding site [chemical binding]; other site
325240005089	oxyanion hole (OAH) forming residues; other site
325240005090	trimer interface [polypeptide binding]; other site
325240005091	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
325240005092	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
325240005093	substrate binding site [chemical binding]; other site
325240005094	oxyanion hole (OAH) forming residues; other site
325240005095	trimer interface [polypeptide binding]; other site
325240005096	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
325240005097	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
325240005098	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
325240005099	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
325240005100	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
325240005101	NAD(P) binding site [chemical binding]; other site
325240005102	active site
325240005103	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
325240005104	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
325240005105	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
325240005106	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
325240005107	DNA binding residues [nucleotide binding]
325240005108	dimer interface [polypeptide binding]; other site
325240005109	copper binding site [ion binding]; other site
325240005110	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
325240005111	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
325240005112	metal-binding site [ion binding]
325240005113	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
325240005114	Soluble P-type ATPase [General function prediction only]; Region: COG4087
325240005115	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
325240005116	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
325240005117	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
325240005118	ABC transporter; Region: ABC_tran_2; pfam12848
325240005119	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
325240005120	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
325240005121	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
325240005122	EamA-like transporter family; Region: EamA; pfam00892
325240005123	EamA-like transporter family; Region: EamA; pfam00892
325240005124	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
325240005125	FAD binding domain; Region: FAD_binding_4; pfam01565
325240005126	Berberine and berberine like; Region: BBE; pfam08031
325240005127	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240005128	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240005129	Integrase core domain; Region: rve; pfam00665
325240005130	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
325240005131	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
325240005132	PAS domain; Region: PAS_9; pfam13426
325240005133	putative active site [active]
325240005134	heme pocket [chemical binding]; other site
325240005135	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240005136	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240005137	metal binding site [ion binding]; metal-binding site
325240005138	active site
325240005139	I-site; other site
325240005140	Domain of unknown function (DUF1888); Region: DUF1888; pfam08985
325240005141	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
325240005142	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
325240005143	DNA binding site [nucleotide binding]
325240005144	AAA ATPase domain; Region: AAA_16; pfam13191
325240005145	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
325240005146	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
325240005147	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
325240005148	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
325240005149	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240005150	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
325240005151	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
325240005152	Walker A/P-loop; other site
325240005153	ATP binding site [chemical binding]; other site
325240005154	Q-loop/lid; other site
325240005155	ABC transporter signature motif; other site
325240005156	Walker B; other site
325240005157	D-loop; other site
325240005158	H-loop/switch region; other site
325240005159	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
325240005160	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
325240005161	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
325240005162	signal peptidase I; Provisional; Region: PRK10861
325240005163	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
325240005164	Catalytic site [active]
325240005165	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
325240005166	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
325240005167	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
325240005168	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
325240005169	SseB protein; Region: SseB; cl06279
325240005170	Beta-lactamase; Region: Beta-lactamase; pfam00144
325240005171	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
325240005172	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240005173	Coenzyme A binding pocket [chemical binding]; other site
325240005174	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
325240005175	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
325240005176	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
325240005177	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
325240005178	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
325240005179	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
325240005180	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
325240005181	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
325240005182	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
325240005183	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
325240005184	conserved gate region; other site
325240005185	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
325240005186	ABC-ATPase subunit interface; other site
325240005187	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
325240005188	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
325240005189	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
325240005190	dimer interface [polypeptide binding]; other site
325240005191	conserved gate region; other site
325240005192	putative PBP binding loops; other site
325240005193	ABC-ATPase subunit interface; other site
325240005194	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
325240005195	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
325240005196	Walker A/P-loop; other site
325240005197	ATP binding site [chemical binding]; other site
325240005198	Q-loop/lid; other site
325240005199	ABC transporter signature motif; other site
325240005200	Walker B; other site
325240005201	D-loop; other site
325240005202	H-loop/switch region; other site
325240005203	transcriptional regulator PhoU; Provisional; Region: PRK11115
325240005204	PhoU domain; Region: PhoU; pfam01895
325240005205	PhoU domain; Region: PhoU; pfam01895
325240005206	Protein of unknown function (DUF3137); Region: DUF3137; pfam11335
325240005207	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
325240005208	dimer interface [polypeptide binding]; other site
325240005209	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
325240005210	metal binding site [ion binding]; metal-binding site
325240005211	Protein of unknown function (DUF502); Region: DUF502; pfam04367
325240005212	BCCT family transporter; Region: BCCT; pfam02028
325240005213	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
325240005214	active site
325240005215	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
325240005216	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240005217	S-adenosylmethionine binding site [chemical binding]; other site
325240005218	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258
325240005219	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
325240005220	dimer interface [polypeptide binding]; other site
325240005221	active site
325240005222	CoA binding pocket [chemical binding]; other site
325240005223	haloalkane dehalogenase; Provisional; Region: PRK03592
325240005224	peptide synthase; Provisional; Region: PRK09274
325240005225	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
325240005226	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910
325240005227	acyl-activating enzyme (AAE) consensus motif; other site
325240005228	putative AMP binding site [chemical binding]; other site
325240005229	putative active site [active]
325240005230	putative CoA binding site [chemical binding]; other site
325240005231	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
325240005232	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
325240005233	NAD(P) binding site [chemical binding]; other site
325240005234	active site
325240005235	Protein of unknown function (DUF3624); Region: DUF3624; pfam12292
325240005236	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
325240005237	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240005238	putative substrate translocation pore; other site
325240005239	POT family; Region: PTR2; cl17359
325240005240	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
325240005241	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
325240005242	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
325240005243	Walker A/P-loop; other site
325240005244	ATP binding site [chemical binding]; other site
325240005245	Q-loop/lid; other site
325240005246	ABC transporter signature motif; other site
325240005247	Walker B; other site
325240005248	D-loop; other site
325240005249	H-loop/switch region; other site
325240005250	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
325240005251	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
325240005252	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
325240005253	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
325240005254	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
325240005255	Zn binding site [ion binding]; other site
325240005256	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
325240005257	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
325240005258	active site
325240005259	substrate binding site [chemical binding]; other site
325240005260	metal binding site [ion binding]; metal-binding site
325240005261	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
325240005262	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
325240005263	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
325240005264	Predicted transcriptional regulator [Transcription]; Region: COG2378
325240005265	HTH domain; Region: HTH_11; pfam08279
325240005266	WYL domain; Region: WYL; pfam13280
325240005267	Aerolysin toxin; Region: Aerolysin; smart00999
325240005268	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
325240005269	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
325240005270	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
325240005271	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
325240005272	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
325240005273	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
325240005274	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
325240005275	trimer interface [polypeptide binding]; other site
325240005276	active site
325240005277	substrate binding site [chemical binding]; other site
325240005278	CoA binding site [chemical binding]; other site
325240005279	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240005280	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240005281	Integrase core domain; Region: rve; pfam00665
325240005282	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
325240005283	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
325240005284	putative pyridoxal-dependent aspartate 1-decarboxylase; Region: NOD_PanD_pyr; TIGR03799
325240005285	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
325240005286	catalytic residue [active]
325240005287	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
325240005288	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
325240005289	fructuronate transporter; Provisional; Region: PRK10034; cl15264
325240005290	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
325240005291	putative heme binding pocket [chemical binding]; other site
325240005292	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240005293	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240005294	Walker A motif; other site
325240005295	ATP binding site [chemical binding]; other site
325240005296	Walker B motif; other site
325240005297	Integrase core domain; Region: rve; pfam00665
325240005298	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
325240005299	Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564
325240005300	DNA methylase; Region: N6_N4_Mtase; pfam01555
325240005301	DNA methylase; Region: N6_N4_Mtase; pfam01555
325240005302	mobile mystery protein B; Region: mob_myst_B; TIGR02613
325240005303	Fic/DOC family; Region: Fic; pfam02661
325240005304	mobile mystery protein A; Region: mob_myst_A; TIGR02612
325240005305	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
325240005306	non-specific DNA binding site [nucleotide binding]; other site
325240005307	salt bridge; other site
325240005308	sequence-specific DNA binding site [nucleotide binding]; other site
325240005309	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
325240005310	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
325240005311	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
325240005312	active site
325240005313	catalytic residues [active]
325240005314	DNA binding site [nucleotide binding]
325240005315	Int/Topo IB signature motif; other site
325240005316	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
325240005317	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
325240005318	active site
325240005319	DNA binding site [nucleotide binding]
325240005320	Int/Topo IB signature motif; other site
325240005321	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
325240005322	ligand binding site [chemical binding]; other site
325240005323	active site
325240005324	Protein of unknown function (DUF3374); Region: DUF3374; pfam11854
325240005325	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
325240005326	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
325240005327	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
325240005328	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
325240005329	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
325240005330	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
325240005331	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
325240005332	heme-binding residues [chemical binding]; other site
325240005333	Protein of unknown function (DUF3374); Region: DUF3374; pfam11854
325240005334	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
325240005335	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
325240005336	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
325240005337	FeoA domain; Region: FeoA; pfam04023
325240005338	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
325240005339	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
325240005340	G1 box; other site
325240005341	GTP/Mg2+ binding site [chemical binding]; other site
325240005342	Switch I region; other site
325240005343	G2 box; other site
325240005344	G3 box; other site
325240005345	Switch II region; other site
325240005346	G4 box; other site
325240005347	G5 box; other site
325240005348	Nucleoside recognition; Region: Gate; pfam07670
325240005349	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
325240005350	Nucleoside recognition; Region: Gate; pfam07670
325240005351	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
325240005352	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
325240005353	active site
325240005354	HIGH motif; other site
325240005355	nucleotide binding site [chemical binding]; other site
325240005356	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
325240005357	KMSKS motif; other site
325240005358	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
325240005359	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
325240005360	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
325240005361	active site
325240005362	dinuclear metal binding site [ion binding]; other site
325240005363	dimerization interface [polypeptide binding]; other site
325240005364	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
325240005365	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
325240005366	putative active site [active]
325240005367	putative metal binding site [ion binding]; other site
325240005368	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
325240005369	substrate binding site [chemical binding]; other site
325240005370	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
325240005371	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
325240005372	active site
325240005373	HIGH motif; other site
325240005374	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
325240005375	KMSKS motif; other site
325240005376	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
325240005377	tRNA binding surface [nucleotide binding]; other site
325240005378	anticodon binding site; other site
325240005379	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
325240005380	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
325240005381	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
325240005382	homodimer interface [polypeptide binding]; other site
325240005383	NADP binding site [chemical binding]; other site
325240005384	substrate binding site [chemical binding]; other site
325240005385	trigger factor; Provisional; Region: tig; PRK01490
325240005386	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
325240005387	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
325240005388	Clp protease; Region: CLP_protease; pfam00574
325240005389	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
325240005390	oligomer interface [polypeptide binding]; other site
325240005391	active site residues [active]
325240005392	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
325240005393	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
325240005394	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240005395	Walker A motif; other site
325240005396	ATP binding site [chemical binding]; other site
325240005397	Walker B motif; other site
325240005398	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
325240005399	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
325240005400	Found in ATP-dependent protease La (LON); Region: LON; smart00464
325240005401	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240005402	Walker A motif; other site
325240005403	ATP binding site [chemical binding]; other site
325240005404	Walker B motif; other site
325240005405	arginine finger; other site
325240005406	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
325240005407	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
325240005408	IHF dimer interface [polypeptide binding]; other site
325240005409	IHF - DNA interface [nucleotide binding]; other site
325240005410	periplasmic folding chaperone; Provisional; Region: PRK10788
325240005411	SurA N-terminal domain; Region: SurA_N_3; cl07813
325240005412	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
325240005413	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
325240005414	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
325240005415	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
325240005416	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
325240005417	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
325240005418	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167
325240005419	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
325240005420	Walker A/P-loop; other site
325240005421	ATP binding site [chemical binding]; other site
325240005422	Q-loop/lid; other site
325240005423	ABC transporter signature motif; other site
325240005424	Walker B; other site
325240005425	D-loop; other site
325240005426	H-loop/switch region; other site
325240005427	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
325240005428	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170
325240005429	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
325240005430	Walker A/P-loop; other site
325240005431	ATP binding site [chemical binding]; other site
325240005432	Q-loop/lid; other site
325240005433	ABC transporter signature motif; other site
325240005434	Walker B; other site
325240005435	D-loop; other site
325240005436	H-loop/switch region; other site
325240005437	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
325240005438	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171
325240005439	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
325240005440	dimer interface [polypeptide binding]; other site
325240005441	conserved gate region; other site
325240005442	putative PBP binding loops; other site
325240005443	ABC-ATPase subunit interface; other site
325240005444	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
325240005445	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
325240005446	dimer interface [polypeptide binding]; other site
325240005447	conserved gate region; other site
325240005448	putative PBP binding loops; other site
325240005449	ABC-ATPase subunit interface; other site
325240005450	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
325240005451	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
325240005452	peptide binding site [polypeptide binding]; other site
325240005453	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
325240005454	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240005455	Walker A motif; other site
325240005456	ATP binding site [chemical binding]; other site
325240005457	Walker B motif; other site
325240005458	arginine finger; other site
325240005459	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
325240005460	phage shock protein A; Region: phageshock_pspA; TIGR02977
325240005461	phage shock protein B; Provisional; Region: pspB; PRK09458
325240005462	phage shock protein C; Region: phageshock_pspC; TIGR02978
325240005463	PspC domain; Region: PspC; cl00864
325240005464	YcjX-like family, DUF463; Region: DUF463; pfam04317
325240005465	hypothetical protein; Provisional; Region: PRK05415
325240005466	Domain of unknown function (DUF697); Region: DUF697; pfam05128
325240005467	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
325240005468	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
325240005469	homodimer interface [polypeptide binding]; other site
325240005470	substrate-cofactor binding pocket; other site
325240005471	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240005472	catalytic residue [active]
325240005473	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
325240005474	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
325240005475	Late competence development protein ComFB; Region: ComFB; pfam10719
325240005476	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
325240005477	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
325240005478	putative active site [active]
325240005479	Zn binding site [ion binding]; other site
325240005480	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
325240005481	Primosomal replication protein priB and priC; Region: priB_priC; cl11483
325240005482	hypothetical protein; Provisional; Region: PRK10621
325240005483	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
325240005484	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
325240005485	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
325240005486	Protein of unknown function (DUF570); Region: DUF570; pfam04489
325240005487	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
325240005488	DNA polymerase II; Reviewed; Region: PRK05762
325240005489	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
325240005490	active site
325240005491	catalytic site [active]
325240005492	substrate binding site [chemical binding]; other site
325240005493	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
325240005494	active site
325240005495	metal-binding site
325240005496	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
325240005497	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
325240005498	trimer interface [polypeptide binding]; other site
325240005499	eyelet of channel; other site
325240005500	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
325240005501	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240005502	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240005503	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
325240005504	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240005505	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
325240005506	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240005507	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240005508	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240005509	Integrase core domain; Region: rve; pfam00665
325240005510	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240005511	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240005512	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240005513	Walker A motif; other site
325240005514	ATP binding site [chemical binding]; other site
325240005515	Walker B motif; other site
325240005516	Integrase core domain; Region: rve; pfam00665
325240005517	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
325240005518	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
325240005519	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
325240005520	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
325240005521	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
325240005522	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
325240005523	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
325240005524	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240005525	TPR motif; other site
325240005526	binding surface
325240005527	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240005528	binding surface
325240005529	TPR motif; other site
325240005530	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240005531	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240005532	metal binding site [ion binding]; metal-binding site
325240005533	active site
325240005534	I-site; other site
325240005535	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
325240005536	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
325240005537	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
325240005538	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
325240005539	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
325240005540	RNA binding surface [nucleotide binding]; other site
325240005541	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
325240005542	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
325240005543	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240005544	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
325240005545	dimerization interface [polypeptide binding]; other site
325240005546	substrate binding pocket [chemical binding]; other site
325240005547	hypothetical protein; Provisional; Region: PRK10621
325240005548	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
325240005549	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
325240005550	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
325240005551	active site
325240005552	metal binding site [ion binding]; metal-binding site
325240005553	DNA binding site [nucleotide binding]
325240005554	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
325240005555	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
325240005556	AAA domain; Region: AAA_23; pfam13476
325240005557	Walker A/P-loop; other site
325240005558	ATP binding site [chemical binding]; other site
325240005559	Q-loop/lid; other site
325240005560	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
325240005561	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
325240005562	ABC transporter signature motif; other site
325240005563	Walker B; other site
325240005564	D-loop; other site
325240005565	H-loop/switch region; other site
325240005566	putative peptidase; Provisional; Region: PRK11649
325240005567	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
325240005568	Peptidase family M23; Region: Peptidase_M23; pfam01551
325240005569	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
325240005570	Protein of unknown function (DUF3010); Region: DUF3010; pfam11215
325240005571	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
325240005572	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
325240005573	ATP binding site [chemical binding]; other site
325240005574	Mg++ binding site [ion binding]; other site
325240005575	motif III; other site
325240005576	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240005577	nucleotide binding region [chemical binding]; other site
325240005578	ATP-binding site [chemical binding]; other site
325240005579	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
325240005580	active site
325240005581	nucleophile elbow; other site
325240005582	Prostaglandin dehydrogenases; Region: PGDH; cd05288
325240005583	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
325240005584	NAD(P) binding site [chemical binding]; other site
325240005585	substrate binding site [chemical binding]; other site
325240005586	dimer interface [polypeptide binding]; other site
325240005587	Transcriptional regulators [Transcription]; Region: MarR; COG1846
325240005588	MarR family; Region: MarR; pfam01047
325240005589	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
325240005590	ATP cone domain; Region: ATP-cone; pfam03477
325240005591	Class III ribonucleotide reductase; Region: RNR_III; cd01675
325240005592	effector binding site; other site
325240005593	active site
325240005594	Zn binding site [ion binding]; other site
325240005595	glycine loop; other site
325240005596	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121
325240005597	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
325240005598	hypothetical protein; Provisional; Region: PRK11020
325240005599	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
325240005600	dimerization interface [polypeptide binding]; other site
325240005601	active site
325240005602	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
325240005603	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
325240005604	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240005605	active site
325240005606	phosphorylation site [posttranslational modification]
325240005607	intermolecular recognition site; other site
325240005608	dimerization interface [polypeptide binding]; other site
325240005609	LytTr DNA-binding domain; Region: LytTR; pfam04397
325240005610	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
325240005611	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
325240005612	GAF domain; Region: GAF_3; pfam13492
325240005613	Histidine kinase; Region: His_kinase; pfam06580
325240005614	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240005615	ATP binding site [chemical binding]; other site
325240005616	Mg2+ binding site [ion binding]; other site
325240005617	G-X-G motif; other site
325240005618	Protein of unknown function (DUF2492); Region: DUF2492; pfam10678
325240005619	ParA-like protein; Provisional; Region: PHA02518
325240005620	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
325240005621	P-loop; other site
325240005622	Magnesium ion binding site [ion binding]; other site
325240005623	PilZ domain; Region: PilZ; pfam07238
325240005624	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
325240005625	NnrS protein; Region: NnrS; pfam05940
325240005626	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
325240005627	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
325240005628	ComEC family competence protein; Provisional; Region: PRK11539
325240005629	Competence protein; Region: Competence; pfam03772
325240005630	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
325240005631	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
325240005632	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
325240005633	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
325240005634	Walker A/P-loop; other site
325240005635	ATP binding site [chemical binding]; other site
325240005636	Q-loop/lid; other site
325240005637	ABC transporter signature motif; other site
325240005638	Walker B; other site
325240005639	D-loop; other site
325240005640	H-loop/switch region; other site
325240005641	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
325240005642	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
325240005643	Uncharacterized conserved protein [Function unknown]; Region: COG2835
325240005644	Predicted membrane protein [Function unknown]; Region: COG3235
325240005645	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
325240005646	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
325240005647	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
325240005648	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
325240005649	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
325240005650	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
325240005651	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
325240005652	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
325240005653	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
325240005654	cytidine deaminase; Provisional; Region: PRK09027
325240005655	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
325240005656	active site
325240005657	catalytic motif [active]
325240005658	Zn binding site [ion binding]; other site
325240005659	Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211
325240005660	exonuclease I; Provisional; Region: sbcB; PRK11779
325240005661	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
325240005662	active site
325240005663	catalytic site [active]
325240005664	substrate binding site [chemical binding]; other site
325240005665	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
325240005666	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
325240005667	dimer interface [polypeptide binding]; other site
325240005668	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
325240005669	ligand binding site [chemical binding]; other site
325240005670	Stf0 sulphotransferase; Region: Sulphotransf; pfam09037
325240005671	Uncharacterized conserved protein [Function unknown]; Region: COG3791
325240005672	Omptin family; Region: Omptin; cl01886
325240005673	DinB family; Region: DinB; cl17821
325240005674	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240005675	putative substrate translocation pore; other site
325240005676	Major Facilitator Superfamily; Region: MFS_1; pfam07690
325240005677	Predicted transcriptional regulators [Transcription]; Region: COG1733
325240005678	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
325240005679	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
325240005680	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240005681	S-adenosylmethionine binding site [chemical binding]; other site
325240005682	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
325240005683	DNA-binding site [nucleotide binding]; DNA binding site
325240005684	RNA-binding motif; other site
325240005685	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
325240005686	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
325240005687	Sulfate transporter family; Region: Sulfate_transp; pfam00916
325240005688	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
325240005689	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
325240005690	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
325240005691	homodimer interface [polypeptide binding]; other site
325240005692	oligonucleotide binding site [chemical binding]; other site
325240005693	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
325240005694	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
325240005695	RNA binding surface [nucleotide binding]; other site
325240005696	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
325240005697	active site
325240005698	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
325240005699	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
325240005700	motif II; other site
325240005701	Maf-like protein; Region: Maf; pfam02545
325240005702	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
325240005703	active site
325240005704	dimer interface [polypeptide binding]; other site
325240005705	hypothetical protein; Provisional; Region: PRK11193
325240005706	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
325240005707	putative phosphate acyltransferase; Provisional; Region: PRK05331
325240005708	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
325240005709	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
325240005710	dimer interface [polypeptide binding]; other site
325240005711	active site
325240005712	CoA binding pocket [chemical binding]; other site
325240005713	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
325240005714	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
325240005715	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
325240005716	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
325240005717	NAD(P) binding site [chemical binding]; other site
325240005718	homotetramer interface [polypeptide binding]; other site
325240005719	homodimer interface [polypeptide binding]; other site
325240005720	active site
325240005721	acyl carrier protein; Provisional; Region: acpP; PRK00982
325240005722	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
325240005723	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
325240005724	dimer interface [polypeptide binding]; other site
325240005725	active site
325240005726	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
325240005727	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
325240005728	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
325240005729	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
325240005730	active site
325240005731	phosphate binding residues; other site
325240005732	catalytic residues [active]
325240005733	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
325240005734	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
325240005735	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
325240005736	active site
325240005737	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
325240005738	putative transposase OrfB; Reviewed; Region: PHA02517
325240005739	HTH-like domain; Region: HTH_21; pfam13276
325240005740	Integrase core domain; Region: rve; pfam00665
325240005741	Integrase core domain; Region: rve_2; pfam13333
325240005742	Transposase; Region: HTH_Tnp_1; pfam01527
325240005743	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240005744	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
325240005745	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
325240005746	N-terminal plug; other site
325240005747	ligand-binding site [chemical binding]; other site
325240005748	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
325240005749	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
325240005750	active site
325240005751	nucleophile elbow; other site
325240005752	asparagine synthetase B; Provisional; Region: asnB; PRK09431
325240005753	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
325240005754	active site
325240005755	dimer interface [polypeptide binding]; other site
325240005756	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
325240005757	Ligand Binding Site [chemical binding]; other site
325240005758	Molecular Tunnel; other site
325240005759	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
325240005760	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
325240005761	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
325240005762	PA/protease or protease-like domain interface [polypeptide binding]; other site
325240005763	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
325240005764	metal binding site [ion binding]; metal-binding site
325240005765	UMP phosphatase; Provisional; Region: PRK10444
325240005766	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
325240005767	active site
325240005768	motif I; other site
325240005769	motif II; other site
325240005770	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
325240005771	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
325240005772	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
325240005773	active site
325240005774	substrate binding site [chemical binding]; other site
325240005775	cosubstrate binding site; other site
325240005776	catalytic site [active]
325240005777	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
325240005778	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
325240005779	dimerization interface [polypeptide binding]; other site
325240005780	putative ATP binding site [chemical binding]; other site
325240005781	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
325240005782	active site
325240005783	Predicted permease [General function prediction only]; Region: COG2056
325240005784	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
325240005785	peroxidase; Provisional; Region: PRK15000
325240005786	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
325240005787	dimer interface [polypeptide binding]; other site
325240005788	decamer (pentamer of dimers) interface [polypeptide binding]; other site
325240005789	catalytic triad [active]
325240005790	peroxidatic and resolving cysteines [active]
325240005791	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
325240005792	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
325240005793	dimer interface [polypeptide binding]; other site
325240005794	catalytic site [active]
325240005795	putative active site [active]
325240005796	putative substrate binding site [chemical binding]; other site
325240005797	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
325240005798	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
325240005799	ligand binding site [chemical binding]; other site
325240005800	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
325240005801	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
325240005802	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
325240005803	active site
325240005804	TolQ protein; Region: tolQ; TIGR02796
325240005805	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
325240005806	TolR protein; Region: tolR; TIGR02801
325240005807	TolA protein; Region: tolA_full; TIGR02794
325240005808	TolA C-terminal; Region: TolA; pfam06519
325240005809	translocation protein TolB; Provisional; Region: tolB; PRK04792
325240005810	TolB amino-terminal domain; Region: TolB_N; pfam04052
325240005811	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
325240005812	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
325240005813	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
325240005814	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
325240005815	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
325240005816	ligand binding site [chemical binding]; other site
325240005817	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
325240005818	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240005819	binding surface
325240005820	TPR motif; other site
325240005821	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
325240005822	GSH binding site [chemical binding]; other site
325240005823	catalytic residues [active]
325240005824	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
325240005825	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
325240005826	ATP binding site [chemical binding]; other site
325240005827	putative Mg++ binding site [ion binding]; other site
325240005828	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240005829	nucleotide binding region [chemical binding]; other site
325240005830	ATP-binding site [chemical binding]; other site
325240005831	Double zinc ribbon; Region: DZR; pfam12773
325240005832	acetyl-CoA synthetase; Provisional; Region: PRK00174
325240005833	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
325240005834	active site
325240005835	CoA binding site [chemical binding]; other site
325240005836	acyl-activating enzyme (AAE) consensus motif; other site
325240005837	AMP binding site [chemical binding]; other site
325240005838	acetate binding site [chemical binding]; other site
325240005839	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
325240005840	Na binding site [ion binding]; other site
325240005841	PAS domain; Region: PAS; smart00091
325240005842	PAS fold; Region: PAS_7; pfam12860
325240005843	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
325240005844	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240005845	dimer interface [polypeptide binding]; other site
325240005846	phosphorylation site [posttranslational modification]
325240005847	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240005848	ATP binding site [chemical binding]; other site
325240005849	Mg2+ binding site [ion binding]; other site
325240005850	G-X-G motif; other site
325240005851	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
325240005852	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240005853	active site
325240005854	phosphorylation site [posttranslational modification]
325240005855	intermolecular recognition site; other site
325240005856	dimerization interface [polypeptide binding]; other site
325240005857	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
325240005858	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
325240005859	inhibitor-cofactor binding pocket; inhibition site
325240005860	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240005861	catalytic residue [active]
325240005862	biotin synthase; Provisional; Region: PRK15108
325240005863	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
325240005864	FeS/SAM binding site; other site
325240005865	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
325240005866	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
325240005867	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
325240005868	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
325240005869	catalytic residue [active]
325240005870	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
325240005871	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240005872	S-adenosylmethionine binding site [chemical binding]; other site
325240005873	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
325240005874	AAA domain; Region: AAA_26; pfam13500
325240005875	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
325240005876	IHF - DNA interface [nucleotide binding]; other site
325240005877	IHF dimer interface [polypeptide binding]; other site
325240005878	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
325240005879	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240005880	Walker A/P-loop; other site
325240005881	ATP binding site [chemical binding]; other site
325240005882	Q-loop/lid; other site
325240005883	ABC transporter signature motif; other site
325240005884	Walker B; other site
325240005885	D-loop; other site
325240005886	H-loop/switch region; other site
325240005887	hypothetical protein; Provisional; Region: PRK11239
325240005888	Protein of unknown function, DUF480; Region: DUF480; pfam04337
325240005889	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
325240005890	S1 domain; Region: S1_2; pfam13509
325240005891	arginine decarboxylase; Provisional; Region: PRK05354
325240005892	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
325240005893	dimer interface [polypeptide binding]; other site
325240005894	active site
325240005895	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
325240005896	catalytic residues [active]
325240005897	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
325240005898	Adenosylmethionine decarboxylase; Region: SAM_decarbox; cl03253
325240005899	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
325240005900	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
325240005901	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
325240005902	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
325240005903	YceI-like domain; Region: YceI; pfam04264
325240005904	Protein of unknown function (DUF3802); Region: DUF3802; pfam12290
325240005905	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
325240005906	Cache domain; Region: Cache_1; pfam02743
325240005907	PAS fold; Region: PAS_4; pfam08448
325240005908	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
325240005909	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
325240005910	Mg2+ binding site [ion binding]; other site
325240005911	G-X-G motif; other site
325240005912	disulfide bond formation protein B; Provisional; Region: PRK01749
325240005913	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
325240005914	fatty acid metabolism regulator; Provisional; Region: PRK04984
325240005915	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
325240005916	DNA-binding site [nucleotide binding]; DNA binding site
325240005917	FadR C-terminal domain; Region: FadR_C; pfam07840
325240005918	SpoVR family protein; Provisional; Region: PRK11767
325240005919	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
325240005920	hypothetical protein; Provisional; Region: PRK05325
325240005921	PrkA family serine protein kinase; Provisional; Region: PRK15455
325240005922	AAA ATPase domain; Region: AAA_16; pfam13191
325240005923	Walker A motif; other site
325240005924	ATP binding site [chemical binding]; other site
325240005925	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
325240005926	superoxide dismutase; Provisional; Region: PRK10543
325240005927	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
325240005928	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
325240005929	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
325240005930	putative GSH binding site [chemical binding]; other site
325240005931	catalytic residues [active]
325240005932	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
325240005933	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3249
325240005934	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
325240005935	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
325240005936	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240005937	Walker A motif; other site
325240005938	ATP binding site [chemical binding]; other site
325240005939	Walker B motif; other site
325240005940	arginine finger; other site
325240005941	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
325240005942	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
325240005943	ArsC family; Region: ArsC; pfam03960
325240005944	catalytic residues [active]
325240005945	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
325240005946	Peptidase family M48; Region: Peptidase_M48; cl12018
325240005947	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240005948	binding surface
325240005949	TPR motif; other site
325240005950	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
325240005951	CPxP  motif; other site
325240005952	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
325240005953	Domain of unknown function DUF20; Region: UPF0118; pfam01594
325240005954	Tetratricopeptide repeat; Region: TPR_12; pfam13424
325240005955	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240005956	binding surface
325240005957	TPR motif; other site
325240005958	TPR repeat; Region: TPR_11; pfam13414
325240005959	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240005960	binding surface
325240005961	TPR motif; other site
325240005962	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
325240005963	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
325240005964	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
325240005965	DNA binding residues [nucleotide binding]
325240005966	dimerization interface [polypeptide binding]; other site
325240005967	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
325240005968	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
325240005969	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
325240005970	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
325240005971	nucleotide binding site/active site [active]
325240005972	HIT family signature motif; other site
325240005973	catalytic residue [active]
325240005974	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
325240005975	CoenzymeA binding site [chemical binding]; other site
325240005976	subunit interaction site [polypeptide binding]; other site
325240005977	PHB binding site; other site
325240005978	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
325240005979	CoenzymeA binding site [chemical binding]; other site
325240005980	subunit interaction site [polypeptide binding]; other site
325240005981	PHB binding site; other site
325240005982	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
325240005983	putative dimer interface [polypeptide binding]; other site
325240005984	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
325240005985	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
325240005986	N-terminal plug; other site
325240005987	ligand-binding site [chemical binding]; other site
325240005988	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
325240005989	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
325240005990	Phosphotransferase enzyme family; Region: APH; pfam01636
325240005991	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
325240005992	substrate binding site [chemical binding]; other site
325240005993	DoxX; Region: DoxX; pfam07681
325240005994	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
325240005995	putative FMN binding site [chemical binding]; other site
325240005996	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
325240005997	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
325240005998	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
325240005999	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
325240006000	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
325240006001	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
325240006002	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
325240006003	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240006004	Coenzyme A binding pocket [chemical binding]; other site
325240006005	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
325240006006	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
325240006007	substrate binding pocket [chemical binding]; other site
325240006008	membrane-bound complex binding site; other site
325240006009	Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925
325240006010	Domain of unknown function (DUF4401); Region: DUF4401; pfam14351
325240006011	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
325240006012	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
325240006013	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
325240006014	generic binding surface II; other site
325240006015	generic binding surface I; other site
325240006016	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
325240006017	putative catalytic site [active]
325240006018	putative metal binding site [ion binding]; other site
325240006019	putative phosphate binding site [ion binding]; other site
325240006020	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
325240006021	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
325240006022	Integrase core domain; Region: rve; pfam00665
325240006023	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240006024	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240006025	Walker A motif; other site
325240006026	ATP binding site [chemical binding]; other site
325240006027	Walker B motif; other site
325240006028	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
325240006029	HSP70 interaction site [polypeptide binding]; other site
325240006030	exopolyphosphatase; Region: exo_poly_only; TIGR03706
325240006031	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
325240006032	polyphosphate kinase 1; Region: poly_P_kin; TIGR03705
325240006033	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
325240006034	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
325240006035	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
325240006036	domain interface [polypeptide binding]; other site
325240006037	active site
325240006038	catalytic site [active]
325240006039	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
325240006040	domain interface [polypeptide binding]; other site
325240006041	active site
325240006042	catalytic site [active]
325240006043	putative chaperone; Provisional; Region: PRK11678
325240006044	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
325240006045	nucleotide binding site [chemical binding]; other site
325240006046	putative NEF/HSP70 interaction site [polypeptide binding]; other site
325240006047	SBD interface [polypeptide binding]; other site
325240006048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
325240006049	CreA protein; Region: CreA; pfam05981
325240006050	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
325240006051	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240006052	cystathionine beta-lyase; Provisional; Region: PRK09028
325240006053	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
325240006054	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
325240006055	catalytic residue [active]
325240006056	proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785
325240006057	DOMON-like type 9 carbohydrate binding module at the N-terminus of bacterial sensor histidine kinases; Region: CBM9_like_HisKa; cd09622
325240006058	putative ligand binding site [chemical binding]; other site
325240006059	HAMP domain; Region: HAMP; pfam00672
325240006060	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240006061	dimer interface [polypeptide binding]; other site
325240006062	phosphorylation site [posttranslational modification]
325240006063	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240006064	ATP binding site [chemical binding]; other site
325240006065	Mg2+ binding site [ion binding]; other site
325240006066	G-X-G motif; other site
325240006067	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240006068	proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787
325240006069	active site
325240006070	phosphorylation site [posttranslational modification]
325240006071	intermolecular recognition site; other site
325240006072	dimerization interface [polypeptide binding]; other site
325240006073	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
325240006074	DNA binding site [nucleotide binding]
325240006075	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
325240006076	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
325240006077	putative active site [active]
325240006078	putative NTP binding site [chemical binding]; other site
325240006079	putative nucleic acid binding site [nucleotide binding]; other site
325240006080	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
325240006081	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
325240006082	ligand binding site [chemical binding]; other site
325240006083	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
325240006084	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
325240006085	vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461
325240006086	metal ion-dependent adhesion site (MIDAS); other site
325240006087	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
325240006088	active site
325240006089	catalytic site [active]
325240006090	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240006091	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240006092	metal binding site [ion binding]; metal-binding site
325240006093	active site
325240006094	I-site; other site
325240006095	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
325240006096	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
325240006097	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
325240006098	PA/protease or protease-like domain interface [polypeptide binding]; other site
325240006099	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
325240006100	metal binding site [ion binding]; metal-binding site
325240006101	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
325240006102	ATP-grasp domain; Region: ATP-grasp_4; cl17255
325240006103	hypothetical protein; Provisional; Region: PRK11027
325240006104	transcriptional regulator HdfR; Provisional; Region: PRK03601
325240006105	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240006106	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
325240006107	dimerization interface [polypeptide binding]; other site
325240006108	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
325240006109	DNA ligase; Provisional; Region: PRK09125
325240006110	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
325240006111	DNA binding site [nucleotide binding]
325240006112	active site
325240006113	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
325240006114	DNA binding site [nucleotide binding]
325240006115	Uncharacterized conserved protein [Function unknown]; Region: COG4748
325240006116	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
325240006117	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
325240006118	Low molecular weight phosphatase family; Region: LMWPc; cd00115
325240006119	active site
325240006120	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
325240006121	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
325240006122	GTP/Mg2+ binding site [chemical binding]; other site
325240006123	G4 box; other site
325240006124	G5 box; other site
325240006125	G1 box; other site
325240006126	Switch I region; other site
325240006127	G2 box; other site
325240006128	G3 box; other site
325240006129	Switch II region; other site
325240006130	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
325240006131	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
325240006132	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
325240006133	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
325240006134	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
325240006135	methionine sulfoxide reductase A; Provisional; Region: PRK14054
325240006136	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
325240006137	dimer interface [polypeptide binding]; other site
325240006138	active site
325240006139	Schiff base residues; other site
325240006140	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
325240006141	Glycoprotease family; Region: Peptidase_M22; pfam00814
325240006142	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
325240006143	Predicted methyltransferase [General function prediction only]; Region: COG4798
325240006144	Methyltransferase domain; Region: Methyltransf_23; pfam13489
325240006145	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
325240006146	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
325240006147	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
325240006148	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
325240006149	acyl-activating enzyme (AAE) consensus motif; other site
325240006150	putative AMP binding site [chemical binding]; other site
325240006151	putative active site [active]
325240006152	putative CoA binding site [chemical binding]; other site
325240006153	ribonuclease D; Region: rnd; TIGR01388
325240006154	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
325240006155	catalytic site [active]
325240006156	putative active site [active]
325240006157	putative substrate binding site [chemical binding]; other site
325240006158	HRDC domain; Region: HRDC; pfam00570
325240006159	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
325240006160	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
325240006161	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
325240006162	Switch I; other site
325240006163	Switch II; other site
325240006164	septum formation inhibitor; Reviewed; Region: minC; PRK04804
325240006165	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
325240006166	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
325240006167	YcgL domain; Region: YcgL; pfam05166
325240006168	Transglycosylase SLT domain; Region: SLT_2; pfam13406
325240006169	murein hydrolase B; Provisional; Region: PRK10760; cl17906
325240006170	hypothetical protein; Provisional; Region: PRK05170
325240006171	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
325240006172	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240006173	dimer interface [polypeptide binding]; other site
325240006174	putative CheW interface [polypeptide binding]; other site
325240006175	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
325240006176	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
325240006177	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
325240006178	dimer interface [polypeptide binding]; other site
325240006179	motif 1; other site
325240006180	active site
325240006181	motif 2; other site
325240006182	motif 3; other site
325240006183	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
325240006184	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
325240006185	putative tRNA-binding site [nucleotide binding]; other site
325240006186	B3/4 domain; Region: B3_4; pfam03483
325240006187	tRNA synthetase B5 domain; Region: B5; smart00874
325240006188	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
325240006189	dimer interface [polypeptide binding]; other site
325240006190	motif 1; other site
325240006191	motif 3; other site
325240006192	motif 2; other site
325240006193	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
325240006194	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
325240006195	IHF dimer interface [polypeptide binding]; other site
325240006196	IHF - DNA interface [nucleotide binding]; other site
325240006197	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
325240006198	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
325240006199	putative acyl-acceptor binding pocket; other site
325240006200	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
325240006201	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
325240006202	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
325240006203	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
325240006204	dimerization interface [polypeptide binding]; other site
325240006205	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
325240006206	ATP binding site [chemical binding]; other site
325240006207	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
325240006208	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
325240006209	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298
325240006210	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
325240006211	Acylphosphatase; Region: Acylphosphatase; pfam00708
325240006212	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
325240006213	HypF finger; Region: zf-HYPF; pfam07503
325240006214	HypF finger; Region: zf-HYPF; pfam07503
325240006215	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
325240006216	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
325240006217	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
325240006218	putative substrate-binding site; other site
325240006219	nickel binding site [ion binding]; other site
325240006220	Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125
325240006221	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
325240006222	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
325240006223	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
325240006224	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
325240006225	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
325240006226	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
325240006227	catalytic residues [active]
325240006228	Domain of unknown function (DUF4266); Region: DUF4266; pfam14086
325240006229	Protein of unknown function (DUF3570); Region: DUF3570; pfam12094
325240006230	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
325240006231	ApbE family; Region: ApbE; pfam02424
325240006232	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
325240006233	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240006234	active site
325240006235	phosphorylation site [posttranslational modification]
325240006236	intermolecular recognition site; other site
325240006237	dimerization interface [polypeptide binding]; other site
325240006238	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
325240006239	DNA binding site [nucleotide binding]
325240006240	sensor protein QseC; Provisional; Region: PRK10337
325240006241	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240006242	dimer interface [polypeptide binding]; other site
325240006243	phosphorylation site [posttranslational modification]
325240006244	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240006245	ATP binding site [chemical binding]; other site
325240006246	Mg2+ binding site [ion binding]; other site
325240006247	G-X-G motif; other site
325240006248	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
325240006249	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433
325240006250	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
325240006251	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
325240006252	Ligand binding site; other site
325240006253	DXD motif; other site
325240006254	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
325240006255	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
325240006256	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
325240006257	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
325240006258	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
325240006259	Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951
325240006260	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
325240006261	5S rRNA interface [nucleotide binding]; other site
325240006262	CTC domain interface [polypeptide binding]; other site
325240006263	L16 interface [polypeptide binding]; other site
325240006264	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
325240006265	Family of unknown function (DUF490); Region: DUF490; pfam04357
325240006266	Family of unknown function (DUF490); Region: DUF490; pfam04357
325240006267	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
325240006268	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
325240006269	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
325240006270	Surface antigen; Region: Bac_surface_Ag; pfam01103
325240006271	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
325240006272	catalytic nucleophile [active]
325240006273	Predicted membrane protein [Function unknown]; Region: COG4325
325240006274	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
325240006275	FOG: CBS domain [General function prediction only]; Region: COG0517
325240006276	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629
325240006277	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
325240006278	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
325240006279	ATP binding site [chemical binding]; other site
325240006280	putative Mg++ binding site [ion binding]; other site
325240006281	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240006282	nucleotide binding region [chemical binding]; other site
325240006283	ATP-binding site [chemical binding]; other site
325240006284	Helicase associated domain (HA2); Region: HA2; pfam04408
325240006285	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
325240006286	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
325240006287	Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848
325240006288	NapD protein; Region: NapD; pfam03927
325240006289	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
325240006290	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
325240006291	[4Fe-4S] binding site [ion binding]; other site
325240006292	molybdopterin cofactor binding site; other site
325240006293	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
325240006294	molybdopterin cofactor binding site; other site
325240006295	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
325240006296	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
325240006297	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
325240006298	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
325240006299	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
325240006300	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
325240006301	putative dimer interface [polypeptide binding]; other site
325240006302	putative anticodon binding site; other site
325240006303	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
325240006304	homodimer interface [polypeptide binding]; other site
325240006305	motif 1; other site
325240006306	motif 2; other site
325240006307	active site
325240006308	motif 3; other site
325240006309	Protein of unknown function (DUF1640); Region: DUF1640; pfam07798
325240006310	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
325240006311	putative active site [active]
325240006312	putative CoA binding site [chemical binding]; other site
325240006313	nudix motif; other site
325240006314	metal binding site [ion binding]; metal-binding site
325240006315	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
325240006316	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
325240006317	chorismate binding enzyme; Region: Chorismate_bind; cl10555
325240006318	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
325240006319	Fumarase C-terminus; Region: Fumerase_C; pfam05683
325240006320	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
325240006321	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
325240006322	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
325240006323	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240006324	Coenzyme A binding pocket [chemical binding]; other site
325240006325	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231
325240006326	putative active site [active]
325240006327	Zn binding site [ion binding]; other site
325240006328	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
325240006329	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
325240006330	putative catalytic cysteine [active]
325240006331	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
325240006332	putative active site [active]
325240006333	metal binding site [ion binding]; metal-binding site
325240006334	hypothetical protein; Provisional; Region: PRK11111
325240006335	Nitrate and nitrite sensing; Region: NIT; pfam08376
325240006336	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
325240006337	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
325240006338	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240006339	dimer interface [polypeptide binding]; other site
325240006340	putative CheW interface [polypeptide binding]; other site
325240006341	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240006342	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240006343	Walker A motif; other site
325240006344	ATP binding site [chemical binding]; other site
325240006345	Walker B motif; other site
325240006346	Integrase core domain; Region: rve; pfam00665
325240006347	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
325240006348	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
325240006349	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
325240006350	active site
325240006351	DNA binding site [nucleotide binding]
325240006352	Int/Topo IB signature motif; other site
325240006353	putative transposase OrfB; Reviewed; Region: PHA02517
325240006354	HTH-like domain; Region: HTH_21; pfam13276
325240006355	Integrase core domain; Region: rve; pfam00665
325240006356	Integrase core domain; Region: rve_2; pfam13333
325240006357	Transposase; Region: HTH_Tnp_1; pfam01527
325240006358	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240006359	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
325240006360	Transposase; Region: HTH_Tnp_1; cl17663
325240006361	Winged helix-turn helix; Region: HTH_29; pfam13551
325240006362	Homeodomain-like domain; Region: HTH_32; pfam13565
325240006363	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
325240006364	Integrase core domain; Region: rve; pfam00665
325240006365	Integrase core domain; Region: rve_3; pfam13683
325240006366	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240006367	Transposase; Region: HTH_Tnp_1; pfam01527
325240006368	putative transposase OrfB; Reviewed; Region: PHA02517
325240006369	HTH-like domain; Region: HTH_21; pfam13276
325240006370	Integrase core domain; Region: rve; pfam00665
325240006371	Integrase core domain; Region: rve_3; pfam13683
325240006372	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
325240006373	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
325240006374	DNA-binding site [nucleotide binding]; DNA binding site
325240006375	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
325240006376	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240006377	homodimer interface [polypeptide binding]; other site
325240006378	catalytic residue [active]
325240006379	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
325240006380	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
325240006381	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
325240006382	EamA-like transporter family; Region: EamA; pfam00892
325240006383	EamA-like transporter family; Region: EamA; pfam00892
325240006384	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
325240006385	Helix-turn-helix domain; Region: HTH_28; pfam13518
325240006386	Winged helix-turn helix; Region: HTH_29; pfam13551
325240006387	Homeodomain-like domain; Region: HTH_32; pfam13565
325240006388	Integrase core domain; Region: rve; pfam00665
325240006389	DDE domain; Region: DDE_Tnp_IS240; pfam13610
325240006390	Integrase core domain; Region: rve_3; pfam13683
325240006391	two component system sensor kinase SsrB; Provisional; Region: PRK15369
325240006392	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240006393	active site
325240006394	phosphorylation site [posttranslational modification]
325240006395	intermolecular recognition site; other site
325240006396	dimerization interface [polypeptide binding]; other site
325240006397	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
325240006398	DNA binding residues [nucleotide binding]
325240006399	dimerization interface [polypeptide binding]; other site
325240006400	two component system sensor kinase SsrA; Provisional; Region: PRK15347
325240006401	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240006402	dimerization interface [polypeptide binding]; other site
325240006403	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240006404	dimer interface [polypeptide binding]; other site
325240006405	phosphorylation site [posttranslational modification]
325240006406	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240006407	ATP binding site [chemical binding]; other site
325240006408	Mg2+ binding site [ion binding]; other site
325240006409	G-X-G motif; other site
325240006410	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240006411	active site
325240006412	phosphorylation site [posttranslational modification]
325240006413	intermolecular recognition site; other site
325240006414	dimerization interface [polypeptide binding]; other site
325240006415	pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368
325240006416	outer membrane secretin SsaC; Provisional; Region: PRK15346
325240006417	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
325240006418	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
325240006419	type III secretion system protein SsaD; Provisional; Region: PRK15367
325240006420	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
325240006421	EspA-like secreted protein; Region: EspA; pfam03433
325240006422	EspA-like secreted protein; Region: EspA; pfam03433
325240006423	pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363
325240006424	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240006425	binding surface
325240006426	TPR motif; other site
325240006427	pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362
325240006428	pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361
325240006429	pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360
325240006430	Salmonella outer protein D; Region: SopD; cl14701
325240006431	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
325240006432	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240006433	binding surface
325240006434	TPR motif; other site
325240006435	pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358
325240006436	Helix-turn-helix domain; Region: HTH_18; pfam12833
325240006437	Type III secretion needle MxiH like; Region: MxiH; cl09641
325240006438	Protein of unknown function (DUF1039); Region: DUF1039; pfam06287
325240006439	Type III secretion needle MxiH like; Region: MxiH; cl09641
325240006440	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
325240006441	Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327
325240006442	type III secretion system protein SsaK; Provisional; Region: PRK15354
325240006443	HrpJ-like domain; Region: HrpJ; cl15454
325240006444	TyeA; Region: TyeA; cl07611
325240006445	chaperone protein SicP; Provisional; Region: PRK15329
325240006446	SicP binding; Region: SicP-binding; pfam09119
325240006447	type III secretion system protein SsaM; Provisional; Region: PRK15353
325240006448	secretion system apparatus protein SsaV; Provisional; Region: PRK12720
325240006449	FHIPEP family; Region: FHIPEP; pfam00771
325240006450	type III secretion system ATPase; Validated; Region: PRK06820
325240006451	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
325240006452	Walker A motif/ATP binding site; other site
325240006453	Walker B motif; other site
325240006454	type III secretion system protein SsaQ; Validated; Region: PRK08035
325240006455	type III secretion system protein YscR; Provisional; Region: PRK12797
325240006456	Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794
325240006457	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
325240006458	secretion system apparatus protein SsaU; Reviewed; Region: PRK12721
325240006459	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
325240006460	Cupin domain; Region: Cupin_2; cl17218
325240006461	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
325240006462	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
325240006463	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
325240006464	EamA-like transporter family; Region: EamA; pfam00892
325240006465	isoaspartyl dipeptidase; Provisional; Region: PRK10657
325240006466	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
325240006467	active site
325240006468	hypothetical protein; Provisional; Region: PRK11588
325240006469	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
325240006470	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
325240006471	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
325240006472	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
325240006473	ligand-binding site [chemical binding]; other site
325240006474	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
325240006475	proposed catalytic triad [active]
325240006476	active site nucleophile [active]
325240006477	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
325240006478	substrate binding site [chemical binding]; other site
325240006479	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
325240006480	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
325240006481	ATP binding site [chemical binding]; other site
325240006482	Mg++ binding site [ion binding]; other site
325240006483	motif III; other site
325240006484	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240006485	nucleotide binding region [chemical binding]; other site
325240006486	ATP-binding site [chemical binding]; other site
325240006487	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
325240006488	ribonuclease activity regulator protein RraA; Reviewed; Region: PRK12487
325240006489	AsmA family; Region: AsmA; pfam05170
325240006490	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
325240006491	Intracellular proteinase inhibitor; Region: BsuPI; pfam12690
325240006492	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
325240006493	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
325240006494	N-acetyl-D-glucosamine binding site [chemical binding]; other site
325240006495	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
325240006496	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
325240006497	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
325240006498	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
325240006499	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
325240006500	Methyltransferase domain; Region: Methyltransf_11; pfam08241
325240006501	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
325240006502	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240006503	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
325240006504	putative dimerization interface [polypeptide binding]; other site
325240006505	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
325240006506	RNA/DNA hybrid binding site [nucleotide binding]; other site
325240006507	active site
325240006508	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
325240006509	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
325240006510	active site
325240006511	catalytic site [active]
325240006512	substrate binding site [chemical binding]; other site
325240006513	TIGR03503 family protein; Region: TIGR03503
325240006514	DDE superfamily endonuclease; Region: DDE_3; pfam13358
325240006515	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
325240006516	Transposase; Region: HTH_Tnp_1; pfam01527
325240006517	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240006518	putative transposase OrfB; Reviewed; Region: PHA02517
325240006519	HTH-like domain; Region: HTH_21; pfam13276
325240006520	Integrase core domain; Region: rve; pfam00665
325240006521	Integrase core domain; Region: rve_2; pfam13333
325240006522	putative transposase OrfB; Reviewed; Region: PHA02517
325240006523	HTH-like domain; Region: HTH_21; pfam13276
325240006524	Integrase core domain; Region: rve; pfam00665
325240006525	Integrase core domain; Region: rve_2; pfam13333
325240006526	Transposase; Region: HTH_Tnp_1; pfam01527
325240006527	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240006528	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
325240006529	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240006530	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
325240006531	GAF domain; Region: GAF; pfam01590
325240006532	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240006533	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240006534	metal binding site [ion binding]; metal-binding site
325240006535	active site
325240006536	I-site; other site
325240006537	Response regulator receiver domain; Region: Response_reg; pfam00072
325240006538	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
325240006539	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
325240006540	Zn2+ binding site [ion binding]; other site
325240006541	Mg2+ binding site [ion binding]; other site
325240006542	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
325240006543	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240006544	ATP binding site [chemical binding]; other site
325240006545	Mg2+ binding site [ion binding]; other site
325240006546	G-X-G motif; other site
325240006547	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240006548	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
325240006549	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
325240006550	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
325240006551	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
325240006552	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240006553	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240006554	Walker A motif; other site
325240006555	ATP binding site [chemical binding]; other site
325240006556	Walker B motif; other site
325240006557	Integrase core domain; Region: rve; pfam00665
325240006558	ThiC family; Region: ThiC; cl08031
325240006559	Phosphomethylpyrimidine kinase; Region: Phos_pyr_kin; pfam08543
325240006560	ATP binding site [chemical binding]; other site
325240006561	substrate binding site [chemical binding]; other site
325240006562	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
325240006563	thiamine phosphate binding site [chemical binding]; other site
325240006564	active site
325240006565	pyrophosphate binding site [ion binding]; other site
325240006566	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
325240006567	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
325240006568	ATP binding site [chemical binding]; other site
325240006569	substrate interface [chemical binding]; other site
325240006570	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
325240006571	thiS-thiF/thiG interaction site; other site
325240006572	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
325240006573	ThiS interaction site; other site
325240006574	putative active site [active]
325240006575	tetramer interface [polypeptide binding]; other site
325240006576	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
325240006577	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
325240006578	FeS/SAM binding site; other site
325240006579	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
325240006580	SprA-related family; Region: SprA-related; pfam12118
325240006581	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240006582	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240006583	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
325240006584	dimerization interface [polypeptide binding]; other site
325240006585	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
325240006586	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
325240006587	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
325240006588	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
325240006589	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
325240006590	Methyltransferase domain; Region: Methyltransf_23; pfam13489
325240006591	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240006592	S-adenosylmethionine binding site [chemical binding]; other site
325240006593	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240006594	S-adenosylmethionine binding site [chemical binding]; other site
325240006595	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
325240006596	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
325240006597	substrate binding pocket [chemical binding]; other site
325240006598	membrane-bound complex binding site; other site
325240006599	hinge residues; other site
325240006600	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
325240006601	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
325240006602	substrate binding pocket [chemical binding]; other site
325240006603	membrane-bound complex binding site; other site
325240006604	hinge residues; other site
325240006605	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
325240006606	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
325240006607	substrate binding pocket [chemical binding]; other site
325240006608	membrane-bound complex binding site; other site
325240006609	hinge residues; other site
325240006610	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240006611	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240006612	metal binding site [ion binding]; metal-binding site
325240006613	active site
325240006614	I-site; other site
325240006615	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
325240006616	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
325240006617	dimer interface [polypeptide binding]; other site
325240006618	anticodon binding site; other site
325240006619	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
325240006620	homodimer interface [polypeptide binding]; other site
325240006621	motif 1; other site
325240006622	active site
325240006623	motif 2; other site
325240006624	GAD domain; Region: GAD; pfam02938
325240006625	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
325240006626	active site
325240006627	motif 3; other site
325240006628	hypothetical protein; Validated; Region: PRK00110
325240006629	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
325240006630	active site
325240006631	putative DNA-binding cleft [nucleotide binding]; other site
325240006632	dimer interface [polypeptide binding]; other site
325240006633	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
325240006634	RuvA N terminal domain; Region: RuvA_N; pfam01330
325240006635	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
325240006636	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
325240006637	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240006638	Walker A motif; other site
325240006639	ATP binding site [chemical binding]; other site
325240006640	Walker B motif; other site
325240006641	arginine finger; other site
325240006642	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
325240006643	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240006644	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240006645	Integrase core domain; Region: rve; pfam00665
325240006646	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
325240006647	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
325240006648	N-terminal plug; other site
325240006649	ligand-binding site [chemical binding]; other site
325240006650	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240006651	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240006652	Walker A motif; other site
325240006653	ATP binding site [chemical binding]; other site
325240006654	Walker B motif; other site
325240006655	Integrase core domain; Region: rve; pfam00665
325240006656	Winged helix-turn helix; Region: HTH_29; pfam13551
325240006657	Homeodomain-like domain; Region: HTH_32; pfam13565
325240006658	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
325240006659	Integrase core domain; Region: rve; pfam00665
325240006660	Transposase; Region: HTH_Tnp_1; cl17663
325240006661	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
325240006662	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240006663	active site
325240006664	phosphorylation site [posttranslational modification]
325240006665	intermolecular recognition site; other site
325240006666	dimerization interface [polypeptide binding]; other site
325240006667	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
325240006668	DNA binding site [nucleotide binding]
325240006669	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
325240006670	Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234
325240006671	putative active site [active]
325240006672	Zn binding site [ion binding]; other site
325240006673	Protein of unknown function (DUF1315); Region: DUF1315; cl01215
325240006674	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
325240006675	active site
325240006676	homodimer interface [polypeptide binding]; other site
325240006677	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
325240006678	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
325240006679	tandem repeat interface [polypeptide binding]; other site
325240006680	oligomer interface [polypeptide binding]; other site
325240006681	active site residues [active]
325240006682	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
325240006683	tandem repeat interface [polypeptide binding]; other site
325240006684	oligomer interface [polypeptide binding]; other site
325240006685	active site residues [active]
325240006686	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
325240006687	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
325240006688	active site
325240006689	FMN binding site [chemical binding]; other site
325240006690	2,4-decadienoyl-CoA binding site; other site
325240006691	catalytic residue [active]
325240006692	4Fe-4S cluster binding site [ion binding]; other site
325240006693	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
325240006694	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
325240006695	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
325240006696	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
325240006697	catalytic loop [active]
325240006698	iron binding site [ion binding]; other site
325240006699	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
325240006700	dimer interface [polypeptide binding]; other site
325240006701	putative radical transfer pathway; other site
325240006702	diiron center [ion binding]; other site
325240006703	tyrosyl radical; other site
325240006704	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
325240006705	ATP cone domain; Region: ATP-cone; pfam03477
325240006706	Class I ribonucleotide reductase; Region: RNR_I; cd01679
325240006707	active site
325240006708	dimer interface [polypeptide binding]; other site
325240006709	catalytic residues [active]
325240006710	effector binding site; other site
325240006711	R2 peptide binding site; other site
325240006712	phosphoglycolate phosphatase; Provisional; Region: PRK13222
325240006713	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
325240006714	motif II; other site
325240006715	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
325240006716	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240006717	S-adenosylmethionine binding site [chemical binding]; other site
325240006718	DNA gyrase subunit A; Validated; Region: PRK05560
325240006719	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
325240006720	CAP-like domain; other site
325240006721	active site
325240006722	primary dimer interface [polypeptide binding]; other site
325240006723	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
325240006724	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
325240006725	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
325240006726	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
325240006727	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
325240006728	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
325240006729	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
325240006730	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
325240006731	catalytic residue [active]
325240006732	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240006733	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240006734	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
325240006735	substrate binding pocket [chemical binding]; other site
325240006736	dimerization interface [polypeptide binding]; other site
325240006737	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
325240006738	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
325240006739	hypothetical protein; Provisional; Region: PRK10977
325240006740	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
325240006741	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
325240006742	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240006743	homodimer interface [polypeptide binding]; other site
325240006744	catalytic residue [active]
325240006745	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
325240006746	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
325240006747	hinge; other site
325240006748	active site
325240006749	cytidylate kinase; Provisional; Region: cmk; PRK00023
325240006750	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
325240006751	CMP-binding site; other site
325240006752	The sites determining sugar specificity; other site
325240006753	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
325240006754	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
325240006755	RNA binding site [nucleotide binding]; other site
325240006756	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
325240006757	RNA binding site [nucleotide binding]; other site
325240006758	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
325240006759	RNA binding site [nucleotide binding]; other site
325240006760	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
325240006761	RNA binding site [nucleotide binding]; other site
325240006762	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
325240006763	RNA binding site [nucleotide binding]; other site
325240006764	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
325240006765	RNA binding site [nucleotide binding]; other site
325240006766	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
325240006767	IHF dimer interface [polypeptide binding]; other site
325240006768	IHF - DNA interface [nucleotide binding]; other site
325240006769	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
325240006770	tetratricopeptide repeat protein; Provisional; Region: PRK11788
325240006771	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
325240006772	active site
325240006773	dimer interface [polypeptide binding]; other site
325240006774	short chain dehydrogenase; Provisional; Region: PRK07576
325240006775	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
325240006776	NAD(P) binding site [chemical binding]; other site
325240006777	active site
325240006778	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
325240006779	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
325240006780	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
325240006781	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
325240006782	active site
325240006783	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
325240006784	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
325240006785	Domain of unknown function (DUF1904); Region: DUF1904; pfam08921
325240006786	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
325240006787	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
325240006788	domain interface [polypeptide binding]; other site
325240006789	putative active site [active]
325240006790	catalytic site [active]
325240006791	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
325240006792	domain interface [polypeptide binding]; other site
325240006793	putative active site [active]
325240006794	catalytic site [active]
325240006795	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
325240006796	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
325240006797	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
325240006798	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
325240006799	catalytic residues [active]
325240006800	catalytic nucleophile [active]
325240006801	Presynaptic Site I dimer interface [polypeptide binding]; other site
325240006802	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
325240006803	Synaptic Flat tetramer interface [polypeptide binding]; other site
325240006804	Synaptic Site I dimer interface [polypeptide binding]; other site
325240006805	DNA binding site [nucleotide binding]
325240006806	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
325240006807	DNA-binding interface [nucleotide binding]; DNA binding site
325240006808	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
325240006809	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240006810	putative substrate translocation pore; other site
325240006811	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
325240006812	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
325240006813	Uncharacterized conserved protein [Function unknown]; Region: COG3148
325240006814	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
325240006815	Transposase; Region: HTH_Tnp_1; cl17663
325240006816	Winged helix-turn helix; Region: HTH_29; pfam13551
325240006817	Homeodomain-like domain; Region: HTH_32; pfam13565
325240006818	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
325240006819	Integrase core domain; Region: rve; pfam00665
325240006820	Integrase core domain; Region: rve_3; pfam13683
325240006821	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
325240006822	active site
325240006823	Int/Topo IB signature motif; other site
325240006824	DNA binding site [nucleotide binding]
325240006825	Integrase core domain; Region: rve; pfam00665
325240006826	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240006827	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240006828	Walker A motif; other site
325240006829	ATP binding site [chemical binding]; other site
325240006830	Walker B motif; other site
325240006831	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193
325240006832	DEAD-like helicases superfamily; Region: DEXDc; smart00487
325240006833	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
325240006834	ATP binding site [chemical binding]; other site
325240006835	putative Mg++ binding site [ion binding]; other site
325240006836	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240006837	nucleotide binding region [chemical binding]; other site
325240006838	ATP-binding site [chemical binding]; other site
325240006839	ecotin; Provisional; Region: PRK03719
325240006840	secondary substrate binding site; other site
325240006841	primary substrate binding site; other site
325240006842	inhibition loop; other site
325240006843	dimerization interface [polypeptide binding]; other site
325240006844	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
325240006845	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
325240006846	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
325240006847	MarR family; Region: MarR; pfam01047
325240006848	putative metal dependent hydrolase; Provisional; Region: PRK11598
325240006849	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
325240006850	Sulfatase; Region: Sulfatase; pfam00884
325240006851	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240006852	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240006853	metal binding site [ion binding]; metal-binding site
325240006854	active site
325240006855	I-site; other site
325240006856	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
325240006857	CoA binding domain; Region: CoA_binding_2; pfam13380
325240006858	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
325240006859	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
325240006860	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
325240006861	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240006862	dimer interface [polypeptide binding]; other site
325240006863	putative CheW interface [polypeptide binding]; other site
325240006864	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
325240006865	anti sigma factor interaction site; other site
325240006866	regulatory phosphorylation site [posttranslational modification]; other site
325240006867	Response regulator receiver domain; Region: Response_reg; pfam00072
325240006868	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240006869	active site
325240006870	phosphorylation site [posttranslational modification]
325240006871	intermolecular recognition site; other site
325240006872	dimerization interface [polypeptide binding]; other site
325240006873	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240006874	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240006875	Integrase core domain; Region: rve; pfam00665
325240006876	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
325240006877	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
325240006878	Response regulator receiver domain; Region: Response_reg; pfam00072
325240006879	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240006880	active site
325240006881	phosphorylation site [posttranslational modification]
325240006882	intermolecular recognition site; other site
325240006883	dimerization interface [polypeptide binding]; other site
325240006884	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
325240006885	putative binding surface; other site
325240006886	active site
325240006887	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
325240006888	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240006889	ATP binding site [chemical binding]; other site
325240006890	Mg2+ binding site [ion binding]; other site
325240006891	G-X-G motif; other site
325240006892	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
325240006893	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
325240006894	putative CheA interaction surface; other site
325240006895	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
325240006896	PAS domain; Region: PAS; smart00091
325240006897	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240006898	dimer interface [polypeptide binding]; other site
325240006899	putative CheW interface [polypeptide binding]; other site
325240006900	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
325240006901	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
325240006902	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
325240006903	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487
325240006904	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
325240006905	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240006906	active site
325240006907	phosphorylation site [posttranslational modification]
325240006908	intermolecular recognition site; other site
325240006909	dimerization interface [polypeptide binding]; other site
325240006910	CheB methylesterase; Region: CheB_methylest; pfam01339
325240006911	Hpt domain; Region: Hpt; pfam01627
325240006912	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240006913	active site
325240006914	phosphorylation site [posttranslational modification]
325240006915	intermolecular recognition site; other site
325240006916	dimerization interface [polypeptide binding]; other site
325240006917	Response regulator receiver domain; Region: Response_reg; pfam00072
325240006918	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240006919	active site
325240006920	phosphorylation site [posttranslational modification]
325240006921	intermolecular recognition site; other site
325240006922	dimerization interface [polypeptide binding]; other site
325240006923	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240006924	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240006925	metal binding site [ion binding]; metal-binding site
325240006926	active site
325240006927	I-site; other site
325240006928	Methyltransferase domain; Region: Methyltransf_25; pfam13649
325240006929	S-adenosylmethionine binding site [chemical binding]; other site
325240006930	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
325240006931	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
325240006932	active site
325240006933	Nuclease-related domain; Region: NERD; pfam08378
325240006934	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
325240006935	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
325240006936	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
325240006937	ABC transporter; Region: ABC_tran_2; pfam12848
325240006938	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
325240006939	Uncharacterized conserved protein [Function unknown]; Region: COG4628
325240006940	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
325240006941	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
325240006942	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
325240006943	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
325240006944	non-specific DNA binding site [nucleotide binding]; other site
325240006945	salt bridge; other site
325240006946	sequence-specific DNA binding site [nucleotide binding]; other site
325240006947	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
325240006948	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240006949	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
325240006950	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240006951	dimer interface [polypeptide binding]; other site
325240006952	phosphorylation site [posttranslational modification]
325240006953	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240006954	ATP binding site [chemical binding]; other site
325240006955	Mg2+ binding site [ion binding]; other site
325240006956	G-X-G motif; other site
325240006957	Response regulator receiver domain; Region: Response_reg; pfam00072
325240006958	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240006959	active site
325240006960	phosphorylation site [posttranslational modification]
325240006961	intermolecular recognition site; other site
325240006962	dimerization interface [polypeptide binding]; other site
325240006963	PAS fold; Region: PAS_7; pfam12860
325240006964	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240006965	putative active site [active]
325240006966	heme pocket [chemical binding]; other site
325240006967	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240006968	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240006969	metal binding site [ion binding]; metal-binding site
325240006970	active site
325240006971	I-site; other site
325240006972	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
325240006973	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
325240006974	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
325240006975	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
325240006976	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
325240006977	N-terminal plug; other site
325240006978	ligand-binding site [chemical binding]; other site
325240006979	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240006980	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240006981	Integrase core domain; Region: rve; pfam00665
325240006982	CsbD-like; Region: CsbD; pfam05532
325240006983	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
325240006984	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240006985	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240006986	Walker A motif; other site
325240006987	ATP binding site [chemical binding]; other site
325240006988	Walker B motif; other site
325240006989	Integrase core domain; Region: rve; pfam00665
325240006990	Uncharacterized conserved protein [Function unknown]; Region: COG3461
325240006991	multidrug efflux protein; Reviewed; Region: PRK01766
325240006992	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
325240006993	cation binding site [ion binding]; other site
325240006994	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
325240006995	Lumazine binding domain; Region: Lum_binding; pfam00677
325240006996	Lumazine binding domain; Region: Lum_binding; pfam00677
325240006997	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
325240006998	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
325240006999	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
325240007000	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
325240007001	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
325240007002	active site
325240007003	dimer interface [polypeptide binding]; other site
325240007004	motif 1; other site
325240007005	motif 2; other site
325240007006	motif 3; other site
325240007007	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
325240007008	anticodon binding site; other site
325240007009	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
325240007010	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
325240007011	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
325240007012	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
325240007013	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
325240007014	23S rRNA binding site [nucleotide binding]; other site
325240007015	L21 binding site [polypeptide binding]; other site
325240007016	L13 binding site [polypeptide binding]; other site
325240007017	thioredoxin reductase; Provisional; Region: PRK10262
325240007018	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
325240007019	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
325240007020	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240007021	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240007022	Integrase core domain; Region: rve; pfam00665
325240007023	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
325240007024	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
325240007025	hexamer interface [polypeptide binding]; other site
325240007026	ligand binding site [chemical binding]; other site
325240007027	putative active site [active]
325240007028	NAD(P) binding site [chemical binding]; other site
325240007029	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
325240007030	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
325240007031	putative DNA binding site [nucleotide binding]; other site
325240007032	putative Zn2+ binding site [ion binding]; other site
325240007033	AsnC family; Region: AsnC_trans_reg; pfam01037
325240007034	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
325240007035	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
325240007036	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
325240007037	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
325240007038	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
325240007039	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
325240007040	recombination factor protein RarA; Reviewed; Region: PRK13342
325240007041	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240007042	Walker A motif; other site
325240007043	ATP binding site [chemical binding]; other site
325240007044	Walker B motif; other site
325240007045	arginine finger; other site
325240007046	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
325240007047	camphor resistance protein CrcB; Provisional; Region: PRK14197
325240007048	seryl-tRNA synthetase; Provisional; Region: PRK05431
325240007049	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
325240007050	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
325240007051	dimer interface [polypeptide binding]; other site
325240007052	active site
325240007053	motif 1; other site
325240007054	motif 2; other site
325240007055	motif 3; other site
325240007056	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
325240007057	sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342
325240007058	sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011
325240007059	sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010
325240007060	sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012
325240007061	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
325240007062	YccA-like proteins; Region: YccA_like; cd10433
325240007063	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
325240007064	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240007065	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
325240007066	dimerization interface [polypeptide binding]; other site
325240007067	putative transporter; Provisional; Region: PRK11043
325240007068	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240007069	putative substrate translocation pore; other site
325240007070	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
325240007071	putative efflux protein, MATE family; Region: matE; TIGR00797
325240007072	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
325240007073	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
325240007074	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
325240007075	catalytic residues [active]
325240007076	catalytic nucleophile [active]
325240007077	Presynaptic Site I dimer interface [polypeptide binding]; other site
325240007078	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
325240007079	Synaptic Flat tetramer interface [polypeptide binding]; other site
325240007080	Synaptic Site I dimer interface [polypeptide binding]; other site
325240007081	DNA binding site [nucleotide binding]
325240007082	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
325240007083	DNA-binding interface [nucleotide binding]; DNA binding site
325240007084	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
325240007085	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
325240007086	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
325240007087	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
325240007088	putative active site [active]
325240007089	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
325240007090	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240007091	Walker A/P-loop; other site
325240007092	ATP binding site [chemical binding]; other site
325240007093	Q-loop/lid; other site
325240007094	ABC transporter signature motif; other site
325240007095	Walker B; other site
325240007096	D-loop; other site
325240007097	H-loop/switch region; other site
325240007098	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
325240007099	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
325240007100	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240007101	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
325240007102	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240007103	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
325240007104	Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767
325240007105	catalytic residues [active]
325240007106	catalytic nucleophile [active]
325240007107	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240007108	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240007109	Walker A motif; other site
325240007110	ATP binding site [chemical binding]; other site
325240007111	Walker B motif; other site
325240007112	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
325240007113	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
325240007114	CTX phage RstB protein; Region: CTX_RstB; pfam07459
325240007115	hypothetical protein; Region: PHA01080
325240007116	Protein of unknown function (DUF2523); Region: DUF2523; cl10291
325240007117	putative assembly protein; Region: PHA00350
325240007118	Zonular occludens toxin (Zot); Region: Zot; cl17485
325240007119	replication initiation protein; Region: II; PHA00360
325240007120	Phage replication protein CRI; Region: Phage_CRI; pfam05144
325240007121	Phage X family; Region: Phage_X; pfam05155
325240007122	putative assembly protein; Region: PHA00350
325240007123	Zonular occludens toxin (Zot); Region: Zot; cl17485
325240007124	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
325240007125	Int/Topo IB signature motif; other site
325240007126	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
325240007127	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
325240007128	active site
325240007129	phosphorylation site [posttranslational modification]
325240007130	intermolecular recognition site; other site
325240007131	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
325240007132	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
325240007133	Zn2+ binding site [ion binding]; other site
325240007134	Mg2+ binding site [ion binding]; other site
325240007135	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
325240007136	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
325240007137	Low-spin heme binding site [chemical binding]; other site
325240007138	Putative water exit pathway; other site
325240007139	Binuclear center (active site) [active]
325240007140	Putative proton exit pathway; other site
325240007141	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
325240007142	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
325240007143	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
325240007144	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
325240007145	Cytochrome c; Region: Cytochrom_C; pfam00034
325240007146	Cytochrome c; Region: Cytochrom_C; pfam00034
325240007147	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
325240007148	FixH; Region: FixH; pfam05751
325240007149	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
325240007150	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
325240007151	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
325240007152	metal-binding site [ion binding]
325240007153	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
325240007154	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
325240007155	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
325240007156	Family description; Region: DsbD_2; pfam13386
325240007157	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
325240007158	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
325240007159	ligand binding site [chemical binding]; other site
325240007160	flexible hinge region; other site
325240007161	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
325240007162	putative switch regulator; other site
325240007163	non-specific DNA interactions [nucleotide binding]; other site
325240007164	DNA binding site [nucleotide binding]
325240007165	sequence specific DNA binding site [nucleotide binding]; other site
325240007166	putative cAMP binding site [chemical binding]; other site
325240007167	universal stress protein UspE; Provisional; Region: PRK11175
325240007168	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
325240007169	Ligand Binding Site [chemical binding]; other site
325240007170	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
325240007171	Ligand Binding Site [chemical binding]; other site
325240007172	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
325240007173	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
325240007174	Ligand Binding Site [chemical binding]; other site
325240007175	Protein of unknown function (DUF2987); Region: DUF2987; pfam11205
325240007176	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
325240007177	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
325240007178	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
325240007179	phosphate binding site [ion binding]; other site
325240007180	putative substrate binding pocket [chemical binding]; other site
325240007181	dimer interface [polypeptide binding]; other site
325240007182	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
325240007183	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
325240007184	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240007185	homodimer interface [polypeptide binding]; other site
325240007186	catalytic residue [active]
325240007187	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
325240007188	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
325240007189	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
325240007190	Protein of unknown function (DUF2989); Region: DUF2989; pfam11207
325240007191	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
325240007192	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
325240007193	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
325240007194	quinolinate synthetase; Provisional; Region: PRK09375
325240007195	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
325240007196	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
325240007197	E3 interaction surface; other site
325240007198	lipoyl attachment site [posttranslational modification]; other site
325240007199	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
325240007200	E3 interaction surface; other site
325240007201	lipoyl attachment site [posttranslational modification]; other site
325240007202	e3 binding domain; Region: E3_binding; pfam02817
325240007203	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
325240007204	3-methyl-2-oxobutanate dehydrogenase; Provisional; Region: PTZ00182
325240007205	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
325240007206	alpha subunit interface [polypeptide binding]; other site
325240007207	TPP binding site [chemical binding]; other site
325240007208	heterodimer interface [polypeptide binding]; other site
325240007209	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
325240007210	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
325240007211	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
325240007212	tetramer interface [polypeptide binding]; other site
325240007213	TPP-binding site [chemical binding]; other site
325240007214	heterodimer interface [polypeptide binding]; other site
325240007215	phosphorylation loop region [posttranslational modification]
325240007216	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
325240007217	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
325240007218	putative active site [active]
325240007219	Zn binding site [ion binding]; other site
325240007220	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
325240007221	phosphoglucomutase; Validated; Region: PRK07564
325240007222	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
325240007223	active site
325240007224	substrate binding site [chemical binding]; other site
325240007225	metal binding site [ion binding]; metal-binding site
325240007226	replication initiation regulator SeqA; Provisional; Region: PRK11187
325240007227	PGAP1-like protein; Region: PGAP1; pfam07819
325240007228	acyl-CoA esterase; Provisional; Region: PRK10673
325240007229	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
325240007230	LexA regulated protein; Provisional; Region: PRK11675
325240007231	flavodoxin FldA; Validated; Region: PRK09267
325240007232	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
325240007233	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
325240007234	elongation factor P; Validated; Region: PRK00529
325240007235	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
325240007236	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
325240007237	RNA binding site [nucleotide binding]; other site
325240007238	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
325240007239	RNA binding site [nucleotide binding]; other site
325240007240	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
325240007241	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
325240007242	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
325240007243	Short chain fatty acid transporter; Region: SCFA_trans; cl17380
325240007244	aminotransferase AlaT; Validated; Region: PRK09265
325240007245	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
325240007246	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240007247	homodimer interface [polypeptide binding]; other site
325240007248	catalytic residue [active]
325240007249	5'-nucleotidase; Provisional; Region: PRK03826
325240007250	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
325240007251	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
325240007252	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
325240007253	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
325240007254	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
325240007255	active site
325240007256	intersubunit interface [polypeptide binding]; other site
325240007257	catalytic residue [active]
325240007258	phosphogluconate dehydratase; Validated; Region: PRK09054
325240007259	6-phosphogluconate dehydratase; Region: edd; TIGR01196
325240007260	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
325240007261	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
325240007262	putative active site [active]
325240007263	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
325240007264	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
325240007265	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
325240007266	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
325240007267	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
325240007268	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
325240007269	putative active site [active]
325240007270	pyruvate kinase; Provisional; Region: PRK05826
325240007271	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
325240007272	domain interfaces; other site
325240007273	active site
325240007274	acyl-CoA dehydrogenase; Reviewed; Region: PRK13026
325240007275	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
325240007276	active site
325240007277	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
325240007278	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
325240007279	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
325240007280	Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461
325240007281	active site
325240007282	Zn binding site [ion binding]; other site
325240007283	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
325240007284	Smr domain; Region: Smr; pfam01713
325240007285	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
325240007286	SEC-C motif; Region: SEC-C; pfam02810
325240007287	SEC-C motif; Region: SEC-C; pfam02810
325240007288	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
325240007289	GAF domain; Region: GAF; pfam01590
325240007290	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240007291	PAS domain; Region: PAS_9; pfam13426
325240007292	putative active site [active]
325240007293	heme pocket [chemical binding]; other site
325240007294	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240007295	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240007296	metal binding site [ion binding]; metal-binding site
325240007297	active site
325240007298	I-site; other site
325240007299	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240007300	Protein of unknown function (DUF406); Region: DUF406; pfam04175
325240007301	Ribosomal S4P (gammaproteobacterial); Region: Ribosomal_S4Pg; pfam11993
325240007302	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
325240007303	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
325240007304	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
325240007305	catalytic residue [active]
325240007306	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
325240007307	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
325240007308	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
325240007309	Ligand Binding Site [chemical binding]; other site
325240007310	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
325240007311	excinuclease ABC subunit B; Provisional; Region: PRK05298
325240007312	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
325240007313	ATP binding site [chemical binding]; other site
325240007314	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240007315	nucleotide binding region [chemical binding]; other site
325240007316	ATP-binding site [chemical binding]; other site
325240007317	Ultra-violet resistance protein B; Region: UvrB; pfam12344
325240007318	UvrB/uvrC motif; Region: UVR; pfam02151
325240007319	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240007320	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240007321	active site
325240007322	I-site; other site
325240007323	metal binding site [ion binding]; metal-binding site
325240007324	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240007325	electron transport complex protein RsxA; Provisional; Region: PRK05151
325240007326	ferredoxin; Provisional; Region: PRK08764
325240007327	Putative Fe-S cluster; Region: FeS; pfam04060
325240007328	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
325240007329	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
325240007330	SLBB domain; Region: SLBB; pfam10531
325240007331	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
325240007332	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
325240007333	electron transport complex protein RnfG; Validated; Region: PRK01908
325240007334	electron transport complex RsxE subunit; Provisional; Region: PRK12405
325240007335	endonuclease III; Provisional; Region: PRK10702
325240007336	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
325240007337	minor groove reading motif; other site
325240007338	helix-hairpin-helix signature motif; other site
325240007339	substrate binding pocket [chemical binding]; other site
325240007340	active site
325240007341	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
325240007342	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
325240007343	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240007344	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
325240007345	dimerization interface [polypeptide binding]; other site
325240007346	substrate binding pocket [chemical binding]; other site
325240007347	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
325240007348	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
325240007349	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
325240007350	dimer interface [polypeptide binding]; other site
325240007351	active site
325240007352	metal binding site [ion binding]; metal-binding site
325240007353	glutathione binding site [chemical binding]; other site
325240007354	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
325240007355	TMAO/DMSO reductase; Reviewed; Region: PRK05363
325240007356	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
325240007357	Moco binding site; other site
325240007358	metal coordination site [ion binding]; other site
325240007359	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
325240007360	RmuC family; Region: RmuC; pfam02646
325240007361	lytic murein transglycosylase; Provisional; Region: PRK11619
325240007362	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
325240007363	N-acetyl-D-glucosamine binding site [chemical binding]; other site
325240007364	catalytic residue [active]
325240007365	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240007366	MoxR-like ATPases [General function prediction only]; Region: COG0714
325240007367	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240007368	Walker A motif; other site
325240007369	ATP binding site [chemical binding]; other site
325240007370	Walker B motif; other site
325240007371	arginine finger; other site
325240007372	Protein of unknown function DUF58; Region: DUF58; pfam01882
325240007373	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
325240007374	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
325240007375	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
325240007376	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
325240007377	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
325240007378	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
325240007379	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
325240007380	Part of AAA domain; Region: AAA_19; pfam13245
325240007381	Family description; Region: UvrD_C_2; pfam13538
325240007382	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
325240007383	AAA domain; Region: AAA_30; pfam13604
325240007384	Family description; Region: UvrD_C_2; pfam13538
325240007385	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
325240007386	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240007387	Coenzyme A binding pocket [chemical binding]; other site
325240007388	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240007389	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240007390	metal binding site [ion binding]; metal-binding site
325240007391	active site
325240007392	I-site; other site
325240007393	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
325240007394	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
325240007395	ATP-grasp domain; Region: ATP-grasp_4; cl17255
325240007396	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
325240007397	GAF domain; Region: GAF; pfam01590
325240007398	PAS domain; Region: PAS_9; pfam13426
325240007399	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240007400	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240007401	metal binding site [ion binding]; metal-binding site
325240007402	active site
325240007403	I-site; other site
325240007404	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240007405	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
325240007406	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240007407	S-adenosylmethionine binding site [chemical binding]; other site
325240007408	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
325240007409	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240007410	putative substrate translocation pore; other site
325240007411	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
325240007412	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
325240007413	active site
325240007414	catalytic site [active]
325240007415	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
325240007416	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240007417	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240007418	Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087
325240007419	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340
325240007420	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
325240007421	Ca binding site [ion binding]; other site
325240007422	active site
325240007423	homodimer interface [polypeptide binding]; other site
325240007424	catalytic site [active]
325240007425	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
325240007426	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349
325240007427	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
325240007428	active site
325240007429	catalytic site [active]
325240007430	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
325240007431	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
325240007432	putative metal binding site [ion binding]; other site
325240007433	pyruvate dehydrogenase; Provisional; Region: PRK06546
325240007434	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
325240007435	PYR/PP interface [polypeptide binding]; other site
325240007436	dimer interface [polypeptide binding]; other site
325240007437	tetramer interface [polypeptide binding]; other site
325240007438	TPP binding site [chemical binding]; other site
325240007439	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
325240007440	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
325240007441	TPP-binding site [chemical binding]; other site
325240007442	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
325240007443	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
325240007444	PRC-barrel domain; Region: PRC; pfam05239
325240007445	PRC-barrel domain; Region: PRC; pfam05239
325240007446	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
325240007447	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
325240007448	Walker A/P-loop; other site
325240007449	ATP binding site [chemical binding]; other site
325240007450	Q-loop/lid; other site
325240007451	ABC transporter signature motif; other site
325240007452	Walker B; other site
325240007453	D-loop; other site
325240007454	H-loop/switch region; other site
325240007455	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
325240007456	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
325240007457	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
325240007458	dimer interface [polypeptide binding]; other site
325240007459	conserved gate region; other site
325240007460	ABC-ATPase subunit interface; other site
325240007461	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
325240007462	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
325240007463	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
325240007464	rhombotail lipoprotein; Region: rhombo_lipo; TIGR04179
325240007465	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
325240007466	active site
325240007467	catalytic residues [active]
325240007468	metal binding site [ion binding]; metal-binding site
325240007469	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
325240007470	active site
325240007471	DNA binding site [nucleotide binding]
325240007472	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
325240007473	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
325240007474	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
325240007475	putative active site [active]
325240007476	putative dimer interface [polypeptide binding]; other site
325240007477	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
325240007478	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
325240007479	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
325240007480	active site
325240007481	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
325240007482	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
325240007483	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
325240007484	TrkA-N domain; Region: TrkA_N; pfam02254
325240007485	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
325240007486	active site
325240007487	Int/Topo IB signature motif; other site
325240007488	catalytic residues [active]
325240007489	DNA binding site [nucleotide binding]
325240007490	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
325240007491	Zn2+ binding site [ion binding]; other site
325240007492	Mg2+ binding site [ion binding]; other site
325240007493	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
325240007494	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
325240007495	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
325240007496	active site
325240007497	DNA binding site [nucleotide binding]
325240007498	Int/Topo IB signature motif; other site
325240007499	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
325240007500	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
325240007501	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
325240007502	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
325240007503	putative active site [active]
325240007504	putative NTP binding site [chemical binding]; other site
325240007505	putative nucleic acid binding site [nucleotide binding]; other site
325240007506	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
325240007507	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
325240007508	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
325240007509	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
325240007510	active site
325240007511	nucleotide binding site [chemical binding]; other site
325240007512	HIGH motif; other site
325240007513	KMSKS motif; other site
325240007514	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240007515	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240007516	Walker A motif; other site
325240007517	ATP binding site [chemical binding]; other site
325240007518	Walker B motif; other site
325240007519	Integrase core domain; Region: rve; pfam00665
325240007520	Haemolysin-III related; Region: HlyIII; cl03831
325240007521	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
325240007522	DTW domain; Region: DTW; cl01221
325240007523	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_27; cd04686
325240007524	nudix motif; other site
325240007525	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
325240007526	Family of unknown function (DUF633); Region: DUF633; pfam04816
325240007527	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
325240007528	Helix-turn-helix domain; Region: HTH_18; pfam12833
325240007529	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
325240007530	Uncharacterized conserved protein [Function unknown]; Region: COG2128
325240007531	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
325240007532	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
325240007533	putative RNA binding site [nucleotide binding]; other site
325240007534	Transposase; Region: HTH_Tnp_1; cl17663
325240007535	Winged helix-turn helix; Region: HTH_29; pfam13551
325240007536	Homeodomain-like domain; Region: HTH_32; pfam13565
325240007537	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
325240007538	Integrase core domain; Region: rve; pfam00665
325240007539	Integrase core domain; Region: rve_3; pfam13683
325240007540	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
325240007541	phosphopeptide binding site; other site
325240007542	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
325240007543	Catalytic domain of Protein Kinases; Region: PKc; cd00180
325240007544	active site
325240007545	ATP binding site [chemical binding]; other site
325240007546	substrate binding site [chemical binding]; other site
325240007547	activation loop (A-loop); other site
325240007548	glycogen synthase; Provisional; Region: glgA; PRK00654
325240007549	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240007550	Major Facilitator Superfamily; Region: MFS_1; pfam07690
325240007551	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240007552	Major Facilitator Superfamily; Region: MFS_1; pfam07690
325240007553	Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430
325240007554	Domain interface; other site
325240007555	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
325240007556	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
325240007557	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
325240007558	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
325240007559	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
325240007560	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
325240007561	Citrate transporter; Region: CitMHS; pfam03600
325240007562	transmembrane helices; other site
325240007563	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
325240007564	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
325240007565	Catalytic site [active]
325240007566	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
325240007567	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
325240007568	active site
325240007569	DNA binding site [nucleotide binding]
325240007570	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
325240007571	Uncharacterized conserved protein [Function unknown]; Region: COG2850
325240007572	Cupin-like domain; Region: Cupin_8; pfam13621
325240007573	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
325240007574	active site
325240007575	catalytic site [active]
325240007576	substrate binding site [chemical binding]; other site
325240007577	Transcriptional regulators [Transcription]; Region: PurR; COG1609
325240007578	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
325240007579	DNA binding site [nucleotide binding]
325240007580	domain linker motif; other site
325240007581	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
325240007582	putative dimerization interface [polypeptide binding]; other site
325240007583	putative ligand binding site [chemical binding]; other site
325240007584	Protein of unknown function (DUF3334); Region: DUF3334; pfam11813
325240007585	Cache domain; Region: Cache_2; pfam08269
325240007586	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
325240007587	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240007588	dimerization interface [polypeptide binding]; other site
325240007589	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240007590	dimer interface [polypeptide binding]; other site
325240007591	putative CheW interface [polypeptide binding]; other site
325240007592	Uncharacterized conserved protein [Function unknown]; Region: COG3603
325240007593	Family description; Region: ACT_7; pfam13840
325240007594	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
325240007595	dimerization domain swap beta strand [polypeptide binding]; other site
325240007596	regulatory protein interface [polypeptide binding]; other site
325240007597	active site
325240007598	regulatory phosphorylation site [posttranslational modification]; other site
325240007599	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
325240007600	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
325240007601	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
325240007602	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
325240007603	PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439
325240007604	HPr interaction site; other site
325240007605	glycerol kinase (GK) interaction site [polypeptide binding]; other site
325240007606	active site
325240007607	phosphorylation site [posttranslational modification]
325240007608	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240007609	Major Facilitator Superfamily; Region: MFS_1; pfam07690
325240007610	putative substrate translocation pore; other site
325240007611	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240007612	Vibrio chemotaxis protein N terminus; Region: MCP_N; pfam05581
325240007613	Cache domain; Region: Cache_1; pfam02743
325240007614	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
325240007615	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240007616	dimerization interface [polypeptide binding]; other site
325240007617	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240007618	dimer interface [polypeptide binding]; other site
325240007619	putative CheW interface [polypeptide binding]; other site
325240007620	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
325240007621	trimer interface [polypeptide binding]; other site
325240007622	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
325240007623	eyelet of channel; other site
325240007624	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
325240007625	ArsC family; Region: ArsC; pfam03960
325240007626	putative catalytic residues [active]
325240007627	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
325240007628	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
325240007629	metal binding site [ion binding]; metal-binding site
325240007630	dimer interface [polypeptide binding]; other site
325240007631	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
325240007632	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
325240007633	PBP superfamily domain; Region: PBP_like_2; cl17296
325240007634	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
325240007635	active site clefts [active]
325240007636	zinc binding site [ion binding]; other site
325240007637	dimer interface [polypeptide binding]; other site
325240007638	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
325240007639	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
325240007640	inhibitor-cofactor binding pocket; inhibition site
325240007641	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240007642	catalytic residue [active]
325240007643	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
325240007644	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
325240007645	active site
325240007646	NAD binding site [chemical binding]; other site
325240007647	metal binding site [ion binding]; metal-binding site
325240007648	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
325240007649	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
325240007650	Ligand binding site; other site
325240007651	oligomer interface; other site
325240007652	Protein of unknown function (DUF2897); Region: DUF2897; pfam11446
325240007653	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
325240007654	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
325240007655	active site residue [active]
325240007656	GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060
325240007657	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
325240007658	putative GSH binding site (G-site) [chemical binding]; other site
325240007659	active site cysteine [active]
325240007660	putative C-terminal domain interface [polypeptide binding]; other site
325240007661	putative dimer interface [polypeptide binding]; other site
325240007662	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
325240007663	putative N-terminal domain interface [polypeptide binding]; other site
325240007664	putative dimer interface [polypeptide binding]; other site
325240007665	putative substrate binding pocket (H-site) [chemical binding]; other site
325240007666	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
325240007667	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
325240007668	Sulfate transporter family; Region: Sulfate_transp; pfam00916
325240007669	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
325240007670	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
325240007671	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
325240007672	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
325240007673	DNA-binding site [nucleotide binding]; DNA binding site
325240007674	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
325240007675	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240007676	homodimer interface [polypeptide binding]; other site
325240007677	catalytic residue [active]
325240007678	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240007679	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
325240007680	putative substrate translocation pore; other site
325240007681	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08979
325240007682	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
325240007683	PYR/PP interface [polypeptide binding]; other site
325240007684	dimer interface [polypeptide binding]; other site
325240007685	TPP binding site [chemical binding]; other site
325240007686	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
325240007687	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
325240007688	TPP-binding site [chemical binding]; other site
325240007689	dimer interface [polypeptide binding]; other site
325240007690	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
325240007691	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
325240007692	putative valine binding site [chemical binding]; other site
325240007693	dimer interface [polypeptide binding]; other site
325240007694	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
325240007695	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
325240007696	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
325240007697	putative dimer interface [polypeptide binding]; other site
325240007698	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
325240007699	active site
325240007700	multimer interface [polypeptide binding]; other site
325240007701	FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412
325240007702	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
325240007703	ATP-grasp domain; Region: ATP-grasp_4; cl17255
325240007704	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
325240007705	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
325240007706	catalytic loop [active]
325240007707	iron binding site [ion binding]; other site
325240007708	chaperone protein HscA; Provisional; Region: hscA; PRK05183
325240007709	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
325240007710	nucleotide binding site [chemical binding]; other site
325240007711	putative NEF/HSP70 interaction site [polypeptide binding]; other site
325240007712	SBD interface [polypeptide binding]; other site
325240007713	co-chaperone HscB; Provisional; Region: hscB; PRK05014
325240007714	DnaJ domain; Region: DnaJ; pfam00226
325240007715	HSP70 interaction site [polypeptide binding]; other site
325240007716	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
325240007717	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
325240007718	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
325240007719	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
325240007720	trimerization site [polypeptide binding]; other site
325240007721	active site
325240007722	cysteine desulfurase; Provisional; Region: PRK14012
325240007723	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
325240007724	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
325240007725	catalytic residue [active]
325240007726	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
325240007727	Rrf2 family protein; Region: rrf2_super; TIGR00738
325240007728	serine O-acetyltransferase; Region: cysE; TIGR01172
325240007729	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
325240007730	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
325240007731	trimer interface [polypeptide binding]; other site
325240007732	active site
325240007733	substrate binding site [chemical binding]; other site
325240007734	CoA binding site [chemical binding]; other site
325240007735	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
325240007736	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
325240007737	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
325240007738	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
325240007739	active site
325240007740	dimerization interface [polypeptide binding]; other site
325240007741	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
325240007742	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
325240007743	FtsX-like permease family; Region: FtsX; pfam02687
325240007744	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
325240007745	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
325240007746	Walker A/P-loop; other site
325240007747	ATP binding site [chemical binding]; other site
325240007748	Q-loop/lid; other site
325240007749	ABC transporter signature motif; other site
325240007750	Walker B; other site
325240007751	D-loop; other site
325240007752	H-loop/switch region; other site
325240007753	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
325240007754	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
325240007755	transcription-repair coupling factor; Provisional; Region: PRK10689
325240007756	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
325240007757	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
325240007758	ATP binding site [chemical binding]; other site
325240007759	putative Mg++ binding site [ion binding]; other site
325240007760	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240007761	nucleotide binding region [chemical binding]; other site
325240007762	ATP-binding site [chemical binding]; other site
325240007763	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
325240007764	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
325240007765	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
325240007766	acylphosphatase; Provisional; Region: PRK14429
325240007767	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
325240007768	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
325240007769	Protein of unknown function (DUF3144); Region: DUF3144; pfam11342
325240007770	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
325240007771	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
325240007772	putative active site [active]
325240007773	putative NTP binding site [chemical binding]; other site
325240007774	putative nucleic acid binding site [nucleotide binding]; other site
325240007775	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
325240007776	hypothetical protein; Provisional; Region: PRK04940
325240007777	beta-hexosaminidase; Provisional; Region: PRK05337
325240007778	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
325240007779	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
325240007780	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
325240007781	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
325240007782	S-formylglutathione hydrolase; Region: PLN02442
325240007783	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
325240007784	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
325240007785	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
325240007786	substrate binding site [chemical binding]; other site
325240007787	catalytic Zn binding site [ion binding]; other site
325240007788	NAD binding site [chemical binding]; other site
325240007789	structural Zn binding site [ion binding]; other site
325240007790	dimer interface [polypeptide binding]; other site
325240007791	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240007792	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240007793	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470
325240007794	putative effector binding pocket; other site
325240007795	putative dimerization interface [polypeptide binding]; other site
325240007796	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
325240007797	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
325240007798	Protein of unknown function (DUF938); Region: DUF938; pfam06080
325240007799	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
325240007800	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
325240007801	N-terminal plug; other site
325240007802	ligand-binding site [chemical binding]; other site
325240007803	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
325240007804	DEAD/DEAH box helicase; Region: DEAD; pfam00270
325240007805	DEAD_2; Region: DEAD_2; pfam06733
325240007806	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
325240007807	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
325240007808	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
325240007809	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
325240007810	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
325240007811	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
325240007812	NAD binding site [chemical binding]; other site
325240007813	dimerization interface [polypeptide binding]; other site
325240007814	product binding site; other site
325240007815	substrate binding site [chemical binding]; other site
325240007816	zinc binding site [ion binding]; other site
325240007817	catalytic residues [active]
325240007818	histidinol-phosphate aminotransferase; Provisional; Region: PRK04635
325240007819	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
325240007820	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240007821	homodimer interface [polypeptide binding]; other site
325240007822	catalytic residue [active]
325240007823	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
325240007824	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
325240007825	active site
325240007826	motif I; other site
325240007827	motif II; other site
325240007828	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
325240007829	putative active site pocket [active]
325240007830	4-fold oligomerization interface [polypeptide binding]; other site
325240007831	metal binding residues [ion binding]; metal-binding site
325240007832	3-fold/trimer interface [polypeptide binding]; other site
325240007833	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
325240007834	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
325240007835	putative active site [active]
325240007836	oxyanion strand; other site
325240007837	catalytic triad [active]
325240007838	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
325240007839	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
325240007840	catalytic residues [active]
325240007841	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
325240007842	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
325240007843	substrate binding site [chemical binding]; other site
325240007844	glutamase interaction surface [polypeptide binding]; other site
325240007845	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
325240007846	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
325240007847	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
325240007848	metal binding site [ion binding]; metal-binding site
325240007849	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
325240007850	aromatic amino acid transport protein; Region: araaP; TIGR00837
325240007851	Dicarboxylate transport; Region: DctA-YdbH; pfam11739
325240007852	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
325240007853	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
325240007854	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240007855	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
325240007856	Coenzyme A binding pocket [chemical binding]; other site
325240007857	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
325240007858	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
325240007859	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
325240007860	quinone interaction residues [chemical binding]; other site
325240007861	active site
325240007862	catalytic residues [active]
325240007863	FMN binding site [chemical binding]; other site
325240007864	substrate binding site [chemical binding]; other site
325240007865	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
325240007866	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
325240007867	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
325240007868	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
325240007869	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
325240007870	Protein of unknown function (DUF2835); Region: DUF2835; pfam11197
325240007871	aminopeptidase N; Provisional; Region: pepN; PRK14015
325240007872	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
325240007873	active site
325240007874	Zn binding site [ion binding]; other site
325240007875	carboxy-terminal protease; Provisional; Region: PRK11186
325240007876	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
325240007877	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
325240007878	protein binding site [polypeptide binding]; other site
325240007879	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
325240007880	Catalytic dyad [active]
325240007881	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
325240007882	ProP expression regulator; Provisional; Region: PRK04950
325240007883	ProQ/FINO family; Region: ProQ; smart00945
325240007884	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
325240007885	GAF domain; Region: GAF_2; pfam13185
325240007886	YebG protein; Region: YebG; pfam07130
325240007887	Paraquat-inducible protein A; Region: PqiA; pfam04403
325240007888	Paraquat-inducible protein A; Region: PqiA; pfam04403
325240007889	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
325240007890	mce related protein; Region: MCE; pfam02470
325240007891	mce related protein; Region: MCE; pfam02470
325240007892	mce related protein; Region: MCE; pfam02470
325240007893	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
325240007894	mce related protein; Region: MCE; pfam02470
325240007895	mce related protein; Region: MCE; pfam02470
325240007896	mce related protein; Region: MCE; pfam02470
325240007897	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
325240007898	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
325240007899	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
325240007900	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240007901	S-adenosylmethionine binding site [chemical binding]; other site
325240007902	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
325240007903	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
325240007904	active site
325240007905	PilZ domain; Region: PilZ; cl01260
325240007906	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
325240007907	DNA polymerase III subunit delta'; Validated; Region: PRK08485
325240007908	thymidylate kinase; Validated; Region: tmk; PRK00698
325240007909	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
325240007910	TMP-binding site; other site
325240007911	ATP-binding site [chemical binding]; other site
325240007912	YceG-like family; Region: YceG; pfam02618
325240007913	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
325240007914	dimerization interface [polypeptide binding]; other site
325240007915	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
325240007916	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
325240007917	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240007918	catalytic residue [active]
325240007919	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
325240007920	trimer interface [polypeptide binding]; other site
325240007921	active site
325240007922	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
325240007923	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
325240007924	Sugar specificity; other site
325240007925	Pyrimidine base specificity; other site
325240007926	ATP-binding site [chemical binding]; other site
325240007927	antiporter inner membrane protein; Provisional; Region: PRK11670
325240007928	Domain of unknown function DUF59; Region: DUF59; cl00941
325240007929	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
325240007930	Walker A motif; other site
325240007931	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
325240007932	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
325240007933	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
325240007934	active site
325240007935	HIGH motif; other site
325240007936	KMSKS motif; other site
325240007937	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
325240007938	tRNA binding surface [nucleotide binding]; other site
325240007939	anticodon binding site; other site
325240007940	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
325240007941	dimer interface [polypeptide binding]; other site
325240007942	putative tRNA-binding site [nucleotide binding]; other site
325240007943	Predicted permeases [General function prediction only]; Region: COG0679
325240007944	Uncharacterized conserved protein [Function unknown]; Region: COG0327
325240007945	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
325240007946	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
325240007947	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
325240007948	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
325240007949	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
325240007950	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
325240007951	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
325240007952	rRNA binding site [nucleotide binding]; other site
325240007953	predicted 30S ribosome binding site; other site
325240007954	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
325240007955	Clp amino terminal domain; Region: Clp_N; pfam02861
325240007956	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240007957	Walker A motif; other site
325240007958	ATP binding site [chemical binding]; other site
325240007959	Walker B motif; other site
325240007960	arginine finger; other site
325240007961	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240007962	Walker A motif; other site
325240007963	ATP binding site [chemical binding]; other site
325240007964	Walker B motif; other site
325240007965	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
325240007966	Uncharacterized conserved protein [Function unknown]; Region: COG2127
325240007967	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
325240007968	DNA-binding site [nucleotide binding]; DNA binding site
325240007969	RNA-binding motif; other site
325240007970	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
325240007971	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
325240007972	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
325240007973	pseudouridine synthase; Region: TIGR00093
325240007974	probable active site [active]
325240007975	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
325240007976	nudix motif; other site
325240007977	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
325240007978	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
325240007979	putative lysogenization regulator; Reviewed; Region: PRK00218
325240007980	adenylosuccinate lyase; Provisional; Region: PRK09285
325240007981	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
325240007982	tetramer interface [polypeptide binding]; other site
325240007983	active site
325240007984	Cupin superfamily protein; Region: Cupin_4; pfam08007
325240007985	Cupin-like domain; Region: Cupin_8; pfam13621
325240007986	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
325240007987	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
325240007988	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
325240007989	NAD binding site [chemical binding]; other site
325240007990	Phe binding site; other site
325240007991	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
325240007992	MarR family; Region: MarR; pfam01047
325240007993	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
325240007994	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
325240007995	FAD binding domain; Region: FAD_binding_4; pfam01565
325240007996	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
325240007997	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
325240007998	phosphoenolpyruvate synthase; Validated; Region: PRK06464
325240007999	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
325240008000	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
325240008001	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
325240008002	PEP synthetase regulatory protein; Provisional; Region: PRK05339
325240008003	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
325240008004	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
325240008005	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
325240008006	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
325240008007	aromatic chitin/cellulose binding site residues [chemical binding]; other site
325240008008	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
325240008009	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
325240008010	active site
325240008011	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
325240008012	Chitinase C; Region: ChiC; pfam06483
325240008013	Cellulose-binding domain, chitinase and related proteins; Region: CBD_like; cd12204
325240008014	aromatic chitin/cellulose binding site residues [chemical binding]; other site
325240008015	ligand binding site [chemical binding]; other site
325240008016	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
325240008017	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
325240008018	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240008019	active site
325240008020	phosphorylation site [posttranslational modification]
325240008021	intermolecular recognition site; other site
325240008022	dimerization interface [polypeptide binding]; other site
325240008023	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
325240008024	DNA binding residues [nucleotide binding]
325240008025	dimerization interface [polypeptide binding]; other site
325240008026	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
325240008027	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240008028	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
325240008029	substrate binding site [chemical binding]; other site
325240008030	dimerization interface [polypeptide binding]; other site
325240008031	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
325240008032	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
325240008033	active site
325240008034	interdomain interaction site; other site
325240008035	putative metal-binding site [ion binding]; other site
325240008036	nucleotide binding site [chemical binding]; other site
325240008037	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
325240008038	domain I; other site
325240008039	DNA binding groove [nucleotide binding]
325240008040	phosphate binding site [ion binding]; other site
325240008041	domain II; other site
325240008042	domain III; other site
325240008043	nucleotide binding site [chemical binding]; other site
325240008044	catalytic site [active]
325240008045	domain IV; other site
325240008046	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
325240008047	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
325240008048	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
325240008049	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
325240008050	succinylarginine dihydrolase; Provisional; Region: PRK13281
325240008051	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
325240008052	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
325240008053	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
325240008054	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
325240008055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240008056	active site
325240008057	phosphorylation site [posttranslational modification]
325240008058	intermolecular recognition site; other site
325240008059	dimerization interface [polypeptide binding]; other site
325240008060	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
325240008061	DNA binding site [nucleotide binding]
325240008062	sensor protein PhoQ; Provisional; Region: PRK10815
325240008063	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240008064	ATP binding site [chemical binding]; other site
325240008065	Mg2+ binding site [ion binding]; other site
325240008066	G-X-G motif; other site
325240008067	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
325240008068	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
325240008069	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
325240008070	Zn2+ binding site [ion binding]; other site
325240008071	Mg2+ binding site [ion binding]; other site
325240008072	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
325240008073	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
325240008074	Cl binding site [ion binding]; other site
325240008075	oligomer interface [polypeptide binding]; other site
325240008076	AAA domain; Region: AAA_33; pfam13671
325240008077	NAD-dependent deacetylase; Provisional; Region: PRK00481
325240008078	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
325240008079	NAD+ binding site [chemical binding]; other site
325240008080	substrate binding site [chemical binding]; other site
325240008081	Zn binding site [ion binding]; other site
325240008082	ferric uptake regulator; Provisional; Region: fur; PRK09462
325240008083	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
325240008084	metal binding site 2 [ion binding]; metal-binding site
325240008085	putative DNA binding helix; other site
325240008086	metal binding site 1 [ion binding]; metal-binding site
325240008087	dimer interface [polypeptide binding]; other site
325240008088	structural Zn2+ binding site [ion binding]; other site
325240008089	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
325240008090	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
325240008091	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
325240008092	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
325240008093	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
325240008094	CoA binding domain; Region: CoA_binding; pfam02629
325240008095	CoA-ligase; Region: Ligase_CoA; pfam00549
325240008096	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
325240008097	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
325240008098	CoA-ligase; Region: Ligase_CoA; pfam00549
325240008099	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
325240008100	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
325240008101	E3 interaction surface; other site
325240008102	lipoyl attachment site [posttranslational modification]; other site
325240008103	e3 binding domain; Region: E3_binding; pfam02817
325240008104	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
325240008105	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
325240008106	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
325240008107	TPP-binding site [chemical binding]; other site
325240008108	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
325240008109	PYR/PP interface [polypeptide binding]; other site
325240008110	dimer interface [polypeptide binding]; other site
325240008111	TPP binding site [chemical binding]; other site
325240008112	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
325240008113	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
325240008114	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
325240008115	L-aspartate oxidase; Provisional; Region: PRK06175
325240008116	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
325240008117	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
325240008118	SdhC subunit interface [polypeptide binding]; other site
325240008119	proximal heme binding site [chemical binding]; other site
325240008120	cardiolipin binding site; other site
325240008121	Iron-sulfur protein interface; other site
325240008122	proximal quinone binding site [chemical binding]; other site
325240008123	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
325240008124	Iron-sulfur protein interface; other site
325240008125	proximal quinone binding site [chemical binding]; other site
325240008126	SdhD (CybS) interface [polypeptide binding]; other site
325240008127	proximal heme binding site [chemical binding]; other site
325240008128	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
325240008129	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
325240008130	dimer interface [polypeptide binding]; other site
325240008131	active site
325240008132	citrylCoA binding site [chemical binding]; other site
325240008133	NADH binding [chemical binding]; other site
325240008134	cationic pore residues; other site
325240008135	oxalacetate/citrate binding site [chemical binding]; other site
325240008136	coenzyme A binding site [chemical binding]; other site
325240008137	catalytic triad [active]
325240008138	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
325240008139	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
325240008140	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240008141	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
325240008142	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
325240008143	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
325240008144	Protein of unknown function (DUF2986); Region: DUF2986; pfam11661
325240008145	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
325240008146	putative efflux protein, MATE family; Region: matE; TIGR00797
325240008147	Ion transport protein; Region: Ion_trans; pfam00520
325240008148	Ion channel; Region: Ion_trans_2; pfam07885
325240008149	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
325240008150	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
325240008151	putative metal binding site [ion binding]; other site
325240008152	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
325240008153	Peptidase family M23; Region: Peptidase_M23; pfam01551
325240008154	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
325240008155	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
325240008156	Nucleoid-associated protein [General function prediction only]; Region: COG3081
325240008157	nucleoid-associated protein NdpA; Validated; Region: PRK00378
325240008158	hypothetical protein; Provisional; Region: PRK13689
325240008159	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
325240008160	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
325240008161	Sulfatase; Region: Sulfatase; cl17466
325240008162	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
325240008163	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
325240008164	active site
325240008165	FMN binding site [chemical binding]; other site
325240008166	substrate binding site [chemical binding]; other site
325240008167	homotetramer interface [polypeptide binding]; other site
325240008168	catalytic residue [active]
325240008169	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240008170	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240008171	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
325240008172	dimerization interface [polypeptide binding]; other site
325240008173	hypothetical protein; Provisional; Region: PRK02135
325240008174	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
325240008175	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240008176	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240008177	metal binding site [ion binding]; metal-binding site
325240008178	active site
325240008179	I-site; other site
325240008180	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
325240008181	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
325240008182	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
325240008183	homodimer interface [polypeptide binding]; other site
325240008184	NAD binding pocket [chemical binding]; other site
325240008185	ATP binding pocket [chemical binding]; other site
325240008186	Mg binding site [ion binding]; other site
325240008187	active-site loop [active]
325240008188	inosine/guanosine kinase; Provisional; Region: PRK15074
325240008189	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
325240008190	substrate binding site [chemical binding]; other site
325240008191	ATP binding site [chemical binding]; other site
325240008192	ferrochelatase; Reviewed; Region: hemH; PRK00035
325240008193	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
325240008194	C-terminal domain interface [polypeptide binding]; other site
325240008195	active site
325240008196	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
325240008197	active site
325240008198	N-terminal domain interface [polypeptide binding]; other site
325240008199	adenylate kinase; Reviewed; Region: adk; PRK00279
325240008200	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
325240008201	AMP-binding site [chemical binding]; other site
325240008202	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
325240008203	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
325240008204	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
325240008205	heat shock protein 90; Provisional; Region: PRK05218
325240008206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240008207	ATP binding site [chemical binding]; other site
325240008208	Mg2+ binding site [ion binding]; other site
325240008209	G-X-G motif; other site
325240008210	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
325240008211	Protein export membrane protein; Region: SecD_SecF; cl14618
325240008212	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
325240008213	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
325240008214	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240008215	lipoprotein; Provisional; Region: PRK11679
325240008216	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
325240008217	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
325240008218	dihydrodipicolinate synthase; Region: dapA; TIGR00674
325240008219	dimer interface [polypeptide binding]; other site
325240008220	active site
325240008221	catalytic residue [active]
325240008222	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
325240008223	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
325240008224	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
325240008225	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
325240008226	catalytic triad [active]
325240008227	Lysine efflux permease [General function prediction only]; Region: COG1279
325240008228	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
325240008229	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240008230	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
325240008231	putative dimerization interface [polypeptide binding]; other site
325240008232	heat shock protein HtpX; Provisional; Region: PRK05457
325240008233	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
325240008234	active site pocket [active]
325240008235	oxyanion hole [active]
325240008236	catalytic triad [active]
325240008237	active site nucleophile [active]
325240008238	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
325240008239	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
325240008240	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
325240008241	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
325240008242	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
325240008243	GIY-YIG motif/motif A; other site
325240008244	active site
325240008245	catalytic site [active]
325240008246	putative DNA binding site [nucleotide binding]; other site
325240008247	metal binding site [ion binding]; metal-binding site
325240008248	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
325240008249	response regulator; Provisional; Region: PRK09483
325240008250	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240008251	active site
325240008252	phosphorylation site [posttranslational modification]
325240008253	intermolecular recognition site; other site
325240008254	dimerization interface [polypeptide binding]; other site
325240008255	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
325240008256	DNA binding residues [nucleotide binding]
325240008257	dimerization interface [polypeptide binding]; other site
325240008258	Cache domain; Region: Cache_1; pfam02743
325240008259	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
325240008260	dimerization interface [polypeptide binding]; other site
325240008261	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
325240008262	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240008263	dimer interface [polypeptide binding]; other site
325240008264	putative CheW interface [polypeptide binding]; other site
325240008265	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
325240008266	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
325240008267	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
325240008268	active site 1 [active]
325240008269	dimer interface [polypeptide binding]; other site
325240008270	active site 2 [active]
325240008271	ribosome modulation factor; Provisional; Region: PRK14563
325240008272	Protein of unknown function (DUF3466); Region: DUF3466; pfam11949
325240008273	ABC transporter ATPase component; Reviewed; Region: PRK11147
325240008274	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
325240008275	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
325240008276	ABC transporter; Region: ABC_tran_2; pfam12848
325240008277	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
325240008278	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
325240008279	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
325240008280	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
325240008281	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240008282	S-adenosylmethionine binding site [chemical binding]; other site
325240008283	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240008284	S-adenosylmethionine binding site [chemical binding]; other site
325240008285	putative acetyltransferase YhhY; Provisional; Region: PRK10140
325240008286	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240008287	Coenzyme A binding pocket [chemical binding]; other site
325240008288	recombination protein RecR; Reviewed; Region: recR; PRK00076
325240008289	RecR protein; Region: RecR; pfam02132
325240008290	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
325240008291	putative active site [active]
325240008292	putative metal-binding site [ion binding]; other site
325240008293	tetramer interface [polypeptide binding]; other site
325240008294	hypothetical protein; Validated; Region: PRK00153
325240008295	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14949
325240008296	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240008297	Walker A motif; other site
325240008298	ATP binding site [chemical binding]; other site
325240008299	Walker B motif; other site
325240008300	DNA polymerase III subunit delta'; Validated; Region: PRK08485
325240008301	arginine finger; other site
325240008302	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
325240008303	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
325240008304	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
325240008305	active site
325240008306	hypothetical protein; Provisional; Region: PRK10527
325240008307	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
325240008308	hypothetical protein; Provisional; Region: PRK05409
325240008309	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
325240008310	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
325240008311	FMN binding site [chemical binding]; other site
325240008312	active site
325240008313	catalytic residues [active]
325240008314	substrate binding site [chemical binding]; other site
325240008315	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
325240008316	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
325240008317	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
325240008318	active site
325240008319	metal binding site [ion binding]; metal-binding site
325240008320	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
325240008321	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
325240008322	Transposase; Region: HTH_Tnp_1; cl17663
325240008323	Winged helix-turn helix; Region: HTH_29; pfam13551
325240008324	Homeodomain-like domain; Region: HTH_32; pfam13565
325240008325	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
325240008326	Integrase core domain; Region: rve; pfam00665
325240008327	Integrase core domain; Region: rve_3; pfam13683
325240008328	putative hydrolase; Provisional; Region: PRK11460
325240008329	Protein of unknown function (DUF3389); Region: DUF3389; pfam11869
325240008330	leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411
325240008331	Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599
325240008332	active site
325240008333	Zn binding site [ion binding]; other site
325240008334	Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127
325240008335	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
325240008336	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
325240008337	Transglycosylase SLT domain; Region: SLT_2; pfam13406
325240008338	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
325240008339	N-acetyl-D-glucosamine binding site [chemical binding]; other site
325240008340	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
325240008341	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
325240008342	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
325240008343	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
325240008344	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240008345	active site
325240008346	phosphorylation site [posttranslational modification]
325240008347	intermolecular recognition site; other site
325240008348	dimerization interface [polypeptide binding]; other site
325240008349	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240008350	S-adenosylmethionine binding site [chemical binding]; other site
325240008351	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
325240008352	RNA polymerase sigma factor; Provisional; Region: PRK11924
325240008353	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
325240008354	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
325240008355	DNA binding residues [nucleotide binding]
325240008356	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
325240008357	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
325240008358	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
325240008359	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
325240008360	hypothetical protein; Provisional; Region: PRK11770
325240008361	Domain of unknown function (DUF307); Region: DUF307; pfam03733
325240008362	Domain of unknown function (DUF307); Region: DUF307; pfam03733
325240008363	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
325240008364	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862
325240008365	putative active site [active]
325240008366	Zn binding site [ion binding]; other site
325240008367	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
325240008368	membrane-bound complex binding site; other site
325240008369	hinge residues; other site
325240008370	AMP-binding domain protein; Validated; Region: PRK08315
325240008371	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
325240008372	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
325240008373	acyl-activating enzyme (AAE) consensus motif; other site
325240008374	putative AMP binding site [chemical binding]; other site
325240008375	putative active site [active]
325240008376	putative CoA binding site [chemical binding]; other site
325240008377	Uncharacterized conserved protein [Function unknown]; Region: COG2947
325240008378	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
325240008379	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240008380	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
325240008381	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
325240008382	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
325240008383	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240008384	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240008385	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
325240008386	dimerization interface [polypeptide binding]; other site
325240008387	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
325240008388	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
325240008389	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
325240008390	dimer interface [polypeptide binding]; other site
325240008391	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
325240008392	active site
325240008393	Fe binding site [ion binding]; other site
325240008394	maltose O-acetyltransferase; Provisional; Region: PRK10092
325240008395	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
325240008396	active site
325240008397	substrate binding site [chemical binding]; other site
325240008398	trimer interface [polypeptide binding]; other site
325240008399	CoA binding site [chemical binding]; other site
325240008400	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
325240008401	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
325240008402	Protein of unknown function, DUF482; Region: DUF482; pfam04339
325240008403	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
325240008404	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
325240008405	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
325240008406	Winged helix-turn helix; Region: HTH_29; pfam13551
325240008407	Homeodomain-like domain; Region: HTH_32; pfam13565
325240008408	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
325240008409	Integrase core domain; Region: rve; pfam00665
325240008410	Integrase core domain; Region: rve_3; pfam13683
325240008411	Transposase; Region: HTH_Tnp_1; cl17663
325240008412	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
325240008413	metal binding site [ion binding]; metal-binding site
325240008414	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
325240008415	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
325240008416	active site
325240008417	Zn binding site [ion binding]; other site
325240008418	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
325240008419	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240008420	Coenzyme A binding pocket [chemical binding]; other site
325240008421	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
325240008422	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
325240008423	active site
325240008424	Zn binding site [ion binding]; other site
325240008425	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
325240008426	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
325240008427	active site
325240008428	metal binding site [ion binding]; metal-binding site
325240008429	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
325240008430	hypothetical protein; Provisional; Region: PRK03641
325240008431	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
325240008432	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
325240008433	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
325240008434	active site
325240008435	motif I; other site
325240008436	motif II; other site
325240008437	Transcriptional regulators [Transcription]; Region: GntR; COG1802
325240008438	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
325240008439	DNA-binding site [nucleotide binding]; DNA binding site
325240008440	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
325240008441	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879
325240008442	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
325240008443	dimer interface [polypeptide binding]; other site
325240008444	active site
325240008445	CoA binding pocket [chemical binding]; other site
325240008446	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
325240008447	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
325240008448	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
325240008449	active site
325240008450	catalytic site [active]
325240008451	substrate binding site [chemical binding]; other site
325240008452	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
325240008453	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
325240008454	ligand binding site [chemical binding]; other site
325240008455	flexible hinge region; other site
325240008456	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
325240008457	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
325240008458	metal binding triad; other site
325240008459	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
325240008460	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
325240008461	Na binding site [ion binding]; other site
325240008462	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
325240008463	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
325240008464	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
325240008465	catalytic residues [active]
325240008466	hinge region; other site
325240008467	alpha helical domain; other site
325240008468	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
325240008469	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
325240008470	putative NAD(P) binding site [chemical binding]; other site
325240008471	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
325240008472	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
325240008473	Zn2+ binding site [ion binding]; other site
325240008474	Mg2+ binding site [ion binding]; other site
325240008475	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
325240008476	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
325240008477	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240008478	Integrase core domain; Region: rve; pfam00665
325240008479	Integrase core domain; Region: rve; pfam00665
325240008480	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240008481	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240008482	Walker A motif; other site
325240008483	ATP binding site [chemical binding]; other site
325240008484	Walker B motif; other site
325240008485	Superfamily II helicase [General function prediction only]; Region: COG1204
325240008486	Transposase; Region: HTH_Tnp_1; pfam01527
325240008487	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240008488	putative transposase OrfB; Reviewed; Region: PHA02517
325240008489	HTH-like domain; Region: HTH_21; pfam13276
325240008490	Integrase core domain; Region: rve; pfam00665
325240008491	Integrase core domain; Region: rve_2; pfam13333
325240008492	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
325240008493	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
325240008494	nucleotide binding pocket [chemical binding]; other site
325240008495	K-X-D-G motif; other site
325240008496	catalytic site [active]
325240008497	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
325240008498	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
325240008499	Dimer interface [polypeptide binding]; other site
325240008500	BRCT sequence motif; other site
325240008501	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
325240008502	K-X-D-G motif; other site
325240008503	catalytic site [active]
325240008504	cell division protein ZipA; Provisional; Region: PRK03427
325240008505	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
325240008506	FtsZ protein binding site [polypeptide binding]; other site
325240008507	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
325240008508	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
325240008509	Walker A/P-loop; other site
325240008510	ATP binding site [chemical binding]; other site
325240008511	Q-loop/lid; other site
325240008512	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
325240008513	ABC transporter signature motif; other site
325240008514	Walker B; other site
325240008515	D-loop; other site
325240008516	H-loop/switch region; other site
325240008517	putative sulfate transport protein CysZ; Validated; Region: PRK04949
325240008518	Transposase; Region: HTH_Tnp_1; pfam01527
325240008519	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240008520	putative transposase OrfB; Reviewed; Region: PHA02517
325240008521	HTH-like domain; Region: HTH_21; pfam13276
325240008522	Integrase core domain; Region: rve; pfam00665
325240008523	Integrase core domain; Region: rve_2; pfam13333
325240008524	RDD family; Region: RDD; pfam06271
325240008525	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
325240008526	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
325240008527	dimer interface [polypeptide binding]; other site
325240008528	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240008529	catalytic residue [active]
325240008530	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
325240008531	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
325240008532	gating phenylalanine in ion channel; other site
325240008533	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240008534	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240008535	Walker A motif; other site
325240008536	ATP binding site [chemical binding]; other site
325240008537	Walker B motif; other site
325240008538	Integrase core domain; Region: rve; pfam00665
325240008539	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240008540	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
325240008541	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240008542	formate transporter FocA; Region: formate_focA; TIGR04060
325240008543	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
325240008544	Pyruvate formate lyase 1; Region: PFL1; cd01678
325240008545	coenzyme A binding site [chemical binding]; other site
325240008546	active site
325240008547	catalytic residues [active]
325240008548	glycine loop; other site
325240008549	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
325240008550	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
325240008551	FeS/SAM binding site; other site
325240008552	Protein of unknown function, DUF412; Region: DUF412; pfam04217
325240008553	propionate/acetate kinase; Provisional; Region: PRK12379
325240008554	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
325240008555	nucleotide binding site [chemical binding]; other site
325240008556	butyrate kinase; Provisional; Region: PRK03011
325240008557	phosphate acetyltransferase; Reviewed; Region: PRK05632
325240008558	DRTGG domain; Region: DRTGG; pfam07085
325240008559	phosphate acetyltransferase; Region: pta; TIGR00651
325240008560	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
325240008561	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240008562	S-adenosylmethionine binding site [chemical binding]; other site
325240008563	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
325240008564	Domain of unknown function DUF20; Region: UPF0118; pfam01594
325240008565	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
325240008566	homooctamer interface [polypeptide binding]; other site
325240008567	active site
325240008568	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
325240008569	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
325240008570	putative NAD(P) binding site [chemical binding]; other site
325240008571	putative active site [active]
325240008572	Sodium/glutamate symporter; Region: Glt_symporter; pfam03616
325240008573	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
325240008574	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
325240008575	Catalytic site [active]
325240008576	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
325240008577	FtsX-like permease family; Region: FtsX; pfam02687
325240008578	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
325240008579	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
325240008580	Walker A/P-loop; other site
325240008581	ATP binding site [chemical binding]; other site
325240008582	Q-loop/lid; other site
325240008583	ABC transporter signature motif; other site
325240008584	Walker B; other site
325240008585	D-loop; other site
325240008586	H-loop/switch region; other site
325240008587	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
325240008588	active site
325240008589	catalytic triad [active]
325240008590	oxyanion hole [active]
325240008591	switch loop; other site
325240008592	Protein of unknown function (DUF3083); Region: DUF3083; pfam11281
325240008593	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
325240008594	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
325240008595	Predicted integral membrane protein [Function unknown]; Region: COG0392
325240008596	Uncharacterized conserved protein [Function unknown]; Region: COG2898
325240008597	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
325240008598	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
325240008599	putative inner membrane peptidase; Provisional; Region: PRK11778
325240008600	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
325240008601	tandem repeat interface [polypeptide binding]; other site
325240008602	oligomer interface [polypeptide binding]; other site
325240008603	active site residues [active]
325240008604	extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502
325240008605	Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262
325240008606	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
325240008607	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
325240008608	NAD(P) binding site [chemical binding]; other site
325240008609	active site
325240008610	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
325240008611	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
325240008612	RNA binding surface [nucleotide binding]; other site
325240008613	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
325240008614	probable active site [active]
325240008615	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
325240008616	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
325240008617	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
325240008618	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
325240008619	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
325240008620	active site
325240008621	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
325240008622	anthranilate synthase component I; Provisional; Region: PRK13564
325240008623	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
325240008624	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
325240008625	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
325240008626	glutamine binding [chemical binding]; other site
325240008627	catalytic triad [active]
325240008628	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
325240008629	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
325240008630	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
325240008631	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
325240008632	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
325240008633	active site
325240008634	ribulose/triose binding site [chemical binding]; other site
325240008635	phosphate binding site [ion binding]; other site
325240008636	substrate (anthranilate) binding pocket [chemical binding]; other site
325240008637	product (indole) binding pocket [chemical binding]; other site
325240008638	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
325240008639	active site
325240008640	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
325240008641	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
325240008642	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240008643	catalytic residue [active]
325240008644	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
325240008645	substrate binding site [chemical binding]; other site
325240008646	active site
325240008647	catalytic residues [active]
325240008648	heterodimer interface [polypeptide binding]; other site
325240008649	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
325240008650	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
325240008651	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
325240008652	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
325240008653	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
325240008654	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
325240008655	IucA / IucC family; Region: IucA_IucC; pfam04183
325240008656	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
325240008657	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
325240008658	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
325240008659	N-terminal plug; other site
325240008660	ligand-binding site [chemical binding]; other site
325240008661	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
325240008662	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
325240008663	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
325240008664	intracellular septation protein A; Reviewed; Region: PRK00259
325240008665	YciI-like protein; Reviewed; Region: PRK11370
325240008666	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
325240008667	putative catalytic site [active]
325240008668	putative phosphate binding site [ion binding]; other site
325240008669	active site
325240008670	metal binding site A [ion binding]; metal-binding site
325240008671	DNA binding site [nucleotide binding]
325240008672	putative AP binding site [nucleotide binding]; other site
325240008673	putative metal binding site B [ion binding]; other site
325240008674	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
325240008675	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240008676	Integrase core domain; Region: rve; pfam00665
325240008677	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240008678	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240008679	Walker A motif; other site
325240008680	ATP binding site [chemical binding]; other site
325240008681	Walker B motif; other site
325240008682	PRC-barrel domain; Region: PRC; pfam05239
325240008683	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
325240008684	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
325240008685	ligand binding site [chemical binding]; other site
325240008686	flexible hinge region; other site
325240008687	non-specific DNA interactions [nucleotide binding]; other site
325240008688	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
325240008689	DNA binding site [nucleotide binding]
325240008690	sequence specific DNA binding site [nucleotide binding]; other site
325240008691	putative cAMP binding site [chemical binding]; other site
325240008692	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
325240008693	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
325240008694	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
325240008695	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
325240008696	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240008697	dimer interface [polypeptide binding]; other site
325240008698	putative CheW interface [polypeptide binding]; other site
325240008699	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
325240008700	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
325240008701	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
325240008702	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
325240008703	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
325240008704	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
325240008705	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
325240008706	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
325240008707	catalytic loop [active]
325240008708	iron binding site [ion binding]; other site
325240008709	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
325240008710	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
325240008711	Ligand binding site; other site
325240008712	metal-binding site
325240008713	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
325240008714	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
325240008715	XdhC Rossmann domain; Region: XdhC_C; pfam13478
325240008716	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
325240008717	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
325240008718	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240008719	dimer interface [polypeptide binding]; other site
325240008720	putative CheW interface [polypeptide binding]; other site
325240008721	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
325240008722	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
325240008723	DNA topoisomerase III; Provisional; Region: PRK07726
325240008724	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
325240008725	active site
325240008726	putative interdomain interaction site [polypeptide binding]; other site
325240008727	putative metal-binding site [ion binding]; other site
325240008728	putative nucleotide binding site [chemical binding]; other site
325240008729	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
325240008730	domain I; other site
325240008731	DNA binding groove [nucleotide binding]
325240008732	phosphate binding site [ion binding]; other site
325240008733	domain II; other site
325240008734	domain III; other site
325240008735	nucleotide binding site [chemical binding]; other site
325240008736	catalytic site [active]
325240008737	domain IV; other site
325240008738	amidophosphoribosyltransferase; Provisional; Region: PRK09246
325240008739	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
325240008740	active site
325240008741	tetramer interface [polypeptide binding]; other site
325240008742	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
325240008743	active site
325240008744	Colicin V production protein; Region: Colicin_V; cl00567
325240008745	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
325240008746	Sporulation related domain; Region: SPOR; pfam05036
325240008747	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
325240008748	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
325240008749	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
325240008750	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
325240008751	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
325240008752	dimerization interface 3.5A [polypeptide binding]; other site
325240008753	active site
325240008754	FimV N-terminal domain; Region: FimV_core; TIGR03505
325240008755	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
325240008756	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
325240008757	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
325240008758	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
325240008759	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
325240008760	ligand binding site [chemical binding]; other site
325240008761	NAD binding site [chemical binding]; other site
325240008762	catalytic site [active]
325240008763	homodimer interface [polypeptide binding]; other site
325240008764	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
325240008765	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
325240008766	dimer interface [polypeptide binding]; other site
325240008767	active site
325240008768	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
325240008769	tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197
325240008770	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
325240008771	YfcL protein; Region: YfcL; pfam08891
325240008772	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
325240008773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240008774	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
325240008775	putative substrate translocation pore; other site
325240008776	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
325240008777	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
325240008778	Tetramer interface [polypeptide binding]; other site
325240008779	active site
325240008780	FMN-binding site [chemical binding]; other site
325240008781	HemK family putative methylases; Region: hemK_fam; TIGR00536
325240008782	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240008783	S-adenosylmethionine binding site [chemical binding]; other site
325240008784	hypothetical protein; Provisional; Region: PRK04946
325240008785	Smr domain; Region: Smr; pfam01713
325240008786	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
325240008787	catalytic core [active]
325240008788	Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025
325240008789	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
325240008790	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
325240008791	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
325240008792	Two component regulator propeller; Region: Reg_prop; pfam07494
325240008793	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
325240008794	PAS fold; Region: PAS_3; pfam08447
325240008795	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240008796	PAS domain; Region: PAS_9; pfam13426
325240008797	putative active site [active]
325240008798	heme pocket [chemical binding]; other site
325240008799	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240008800	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240008801	metal binding site [ion binding]; metal-binding site
325240008802	active site
325240008803	I-site; other site
325240008804	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240008805	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
325240008806	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
325240008807	substrate binding site [chemical binding]; other site
325240008808	oxyanion hole (OAH) forming residues; other site
325240008809	trimer interface [polypeptide binding]; other site
325240008810	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
325240008811	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
325240008812	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
325240008813	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
325240008814	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
325240008815	dimer interface [polypeptide binding]; other site
325240008816	active site
325240008817	MoxR-like ATPases [General function prediction only]; Region: COG0714
325240008818	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240008819	Walker A motif; other site
325240008820	ATP binding site [chemical binding]; other site
325240008821	Walker B motif; other site
325240008822	arginine finger; other site
325240008823	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
325240008824	Protein of unknown function DUF58; Region: DUF58; pfam01882
325240008825	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
325240008826	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
325240008827	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
325240008828	metal ion-dependent adhesion site (MIDAS); other site
325240008829	von Willebrand factor type A domain; Region: VWA_2; pfam13519
325240008830	metal ion-dependent adhesion site (MIDAS); other site
325240008831	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
325240008832	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240008833	binding surface
325240008834	TPR motif; other site
325240008835	Oxygen tolerance; Region: BatD; pfam13584
325240008836	RNA polymerase sigma factor; Provisional; Region: PRK12517
325240008837	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
325240008838	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
325240008839	DNA binding residues [nucleotide binding]
325240008840	Protein of unknown function (DUF3379); Region: DUF3379; pfam11859
325240008841	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
325240008842	Na binding site [ion binding]; other site
325240008843	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
325240008844	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
325240008845	active site
325240008846	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
325240008847	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
325240008848	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
325240008849	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240008850	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
325240008851	Protein export membrane protein; Region: SecD_SecF; cl14618
325240008852	Protein export membrane protein; Region: SecD_SecF; cl14618
325240008853	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
325240008854	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
325240008855	active site residue [active]
325240008856	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
325240008857	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240008858	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
325240008859	Coenzyme A binding pocket [chemical binding]; other site
325240008860	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
325240008861	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
325240008862	active site
325240008863	catalytic residues [active]
325240008864	PA_VapT_like: Protease-associated domain containing proteins like VapT from Vibrio metschnikovii strain RH530. This group contains various PA domain-containing proteins similar to V. metschnikovii VapT, including the serine alkaline protease SapSh from...; Region: PA_VapT_like; cd04817
325240008865	PA/subtilisin-like domain interface [polypeptide binding]; other site
325240008866	Subtilase family; Region: Peptidase_S8; pfam00082
325240008867	catalytic residues [active]
325240008868	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
325240008869	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
325240008870	YaeQ protein; Region: YaeQ; pfam07152
325240008871	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
325240008872	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
325240008873	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
325240008874	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
325240008875	active site residue [active]
325240008876	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
325240008877	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
325240008878	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
325240008879	Protein export membrane protein; Region: SecD_SecF; pfam02355
325240008880	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
325240008881	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
325240008882	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
325240008883	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
325240008884	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
325240008885	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
325240008886	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
325240008887	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
325240008888	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
325240008889	Protein of unknown function, DUF479; Region: DUF479; pfam04336
325240008890	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
325240008891	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
325240008892	active site
325240008893	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
325240008894	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
325240008895	serine/threonine transporter SstT; Provisional; Region: PRK13628
325240008896	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
325240008897	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
325240008898	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
325240008899	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240008900	active site
325240008901	phosphorylation site [posttranslational modification]
325240008902	intermolecular recognition site; other site
325240008903	dimerization interface [polypeptide binding]; other site
325240008904	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
325240008905	active site
325240008906	catalytic residues [active]
325240008907	helicase 45; Provisional; Region: PTZ00424
325240008908	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
325240008909	ATP binding site [chemical binding]; other site
325240008910	Mg++ binding site [ion binding]; other site
325240008911	motif III; other site
325240008912	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240008913	nucleotide binding region [chemical binding]; other site
325240008914	ATP-binding site [chemical binding]; other site
325240008915	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
325240008916	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
325240008917	DNA binding site [nucleotide binding]
325240008918	active site
325240008919	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
325240008920	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
325240008921	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
325240008922	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
325240008923	AlkA N-terminal domain; Region: AlkA_N; pfam06029
325240008924	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
325240008925	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
325240008926	minor groove reading motif; other site
325240008927	helix-hairpin-helix signature motif; other site
325240008928	substrate binding pocket [chemical binding]; other site
325240008929	active site
325240008930	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
325240008931	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
325240008932	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
325240008933	Walker A/P-loop; other site
325240008934	ATP binding site [chemical binding]; other site
325240008935	Q-loop/lid; other site
325240008936	ABC transporter signature motif; other site
325240008937	Walker B; other site
325240008938	D-loop; other site
325240008939	H-loop/switch region; other site
325240008940	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
325240008941	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
325240008942	active site
325240008943	HIGH motif; other site
325240008944	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
325240008945	active site
325240008946	KMSKS motif; other site
325240008947	Integrase core domain; Region: rve; pfam00665
325240008948	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240008949	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240008950	Walker A motif; other site
325240008951	ATP binding site [chemical binding]; other site
325240008952	Walker B motif; other site
325240008953	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
325240008954	DctM-like transporters; Region: DctM; pfam06808
325240008955	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
325240008956	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
325240008957	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240008958	dimer interface [polypeptide binding]; other site
325240008959	phosphorylation site [posttranslational modification]
325240008960	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240008961	ATP binding site [chemical binding]; other site
325240008962	Mg2+ binding site [ion binding]; other site
325240008963	G-X-G motif; other site
325240008964	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
325240008965	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240008966	active site
325240008967	phosphorylation site [posttranslational modification]
325240008968	intermolecular recognition site; other site
325240008969	dimerization interface [polypeptide binding]; other site
325240008970	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240008971	Walker A motif; other site
325240008972	ATP binding site [chemical binding]; other site
325240008973	Walker B motif; other site
325240008974	arginine finger; other site
325240008975	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
325240008976	Protein of unknown function, DUF606; Region: DUF606; pfam04657
325240008977	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240008978	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240008979	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
325240008980	putative effector binding pocket; other site
325240008981	dimerization interface [polypeptide binding]; other site
325240008982	Major Facilitator Superfamily; Region: MFS_1; pfam07690
325240008983	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240008984	putative substrate translocation pore; other site
325240008985	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240008986	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240008987	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
325240008988	dimerization interface [polypeptide binding]; other site
325240008989	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
325240008990	Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852
325240008991	active site
325240008992	catalytic triad [active]
325240008993	PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818
325240008994	PA/protease or protease-like domain interface [polypeptide binding]; other site
325240008995	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
325240008996	catalytic residues [active]
325240008997	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
325240008998	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
325240008999	acyl-CoA thioesterase II; Provisional; Region: PRK10526
325240009000	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
325240009001	active site
325240009002	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
325240009003	catalytic triad [active]
325240009004	dimer interface [polypeptide binding]; other site
325240009005	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
325240009006	classical (c) SDRs; Region: SDR_c; cd05233
325240009007	NAD(P) binding site [chemical binding]; other site
325240009008	active site
325240009009	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
325240009010	UbiA prenyltransferase family; Region: UbiA; pfam01040
325240009011	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
325240009012	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
325240009013	putative active site [active]
325240009014	metal binding site [ion binding]; metal-binding site
325240009015	DoxX-like family; Region: DoxX_2; pfam13564
325240009016	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240009017	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240009018	LysR substrate binding domain; Region: LysR_substrate; pfam03466
325240009019	dimerization interface [polypeptide binding]; other site
325240009020	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
325240009021	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
325240009022	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
325240009023	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
325240009024	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
325240009025	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
325240009026	acyl-activating enzyme (AAE) consensus motif; other site
325240009027	AMP binding site [chemical binding]; other site
325240009028	active site
325240009029	CoA binding site [chemical binding]; other site
325240009030	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
325240009031	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
325240009032	DNA binding residues [nucleotide binding]
325240009033	putative dimer interface [polypeptide binding]; other site
325240009034	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
325240009035	isovaleryl-CoA dehydrogenase; Region: PLN02519
325240009036	substrate binding site [chemical binding]; other site
325240009037	FAD binding site [chemical binding]; other site
325240009038	catalytic base [active]
325240009039	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
325240009040	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
325240009041	enoyl-CoA hydratase; Provisional; Region: PRK05995
325240009042	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
325240009043	substrate binding site [chemical binding]; other site
325240009044	oxyanion hole (OAH) forming residues; other site
325240009045	trimer interface [polypeptide binding]; other site
325240009046	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
325240009047	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
325240009048	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
325240009049	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
325240009050	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
325240009051	carboxyltransferase (CT) interaction site; other site
325240009052	biotinylation site [posttranslational modification]; other site
325240009053	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
325240009054	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
325240009055	active site
325240009056	catalytic residues [active]
325240009057	metal binding site [ion binding]; metal-binding site
325240009058	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
325240009059	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
325240009060	Putative amidotransferase; Region: DUF4066; pfam13278
325240009061	conserved cys residue [active]
325240009062	hypothetical protein; Provisional; Region: PRK10621
325240009063	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
325240009064	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
325240009065	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
325240009066	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
325240009067	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
325240009068	Transglycosylase; Region: Transgly; cl17702
325240009069	thymidine kinase; Provisional; Region: PRK04296
325240009070	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
325240009071	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
325240009072	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
325240009073	active site
325240009074	Zn binding site [ion binding]; other site
325240009075	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
325240009076	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
325240009077	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
325240009078	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
325240009079	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
325240009080	Ligand binding site [chemical binding]; other site
325240009081	Electron transfer flavoprotein domain; Region: ETF; pfam01012
325240009082	H-NS histone family; Region: Histone_HNS; pfam00816
325240009083	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
325240009084	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
325240009085	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240009086	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240009087	Integrase core domain; Region: rve; pfam00665
325240009088	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
325240009089	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
325240009090	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
325240009091	active site
325240009092	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
325240009093	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
325240009094	homodimer interaction site [polypeptide binding]; other site
325240009095	cofactor binding site; other site
325240009096	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
325240009097	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
325240009098	putative CoA binding site [chemical binding]; other site
325240009099	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
325240009100	trimer interface [polypeptide binding]; other site
325240009101	active site
325240009102	substrate binding site [chemical binding]; other site
325240009103	CoA binding site [chemical binding]; other site
325240009104	prolyl-tRNA synthetase; Provisional; Region: PRK09194
325240009105	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
325240009106	dimer interface [polypeptide binding]; other site
325240009107	motif 1; other site
325240009108	active site
325240009109	motif 2; other site
325240009110	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
325240009111	putative deacylase active site [active]
325240009112	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
325240009113	active site
325240009114	motif 3; other site
325240009115	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
325240009116	anticodon binding site; other site
325240009117	Cupin domain; Region: Cupin_2; cl17218
325240009118	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
325240009119	Helix-turn-helix domain; Region: HTH_18; pfam12833
325240009120	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
325240009121	active site
325240009122	oligomerization interface [polypeptide binding]; other site
325240009123	metal binding site [ion binding]; metal-binding site
325240009124	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
325240009125	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
325240009126	nucleophile elbow; other site
325240009127	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
325240009128	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
325240009129	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
325240009130	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
325240009131	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
325240009132	active site
325240009133	FMN binding site [chemical binding]; other site
325240009134	substrate binding site [chemical binding]; other site
325240009135	homotetramer interface [polypeptide binding]; other site
325240009136	catalytic residue [active]
325240009137	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
325240009138	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
325240009139	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
325240009140	substrate binding site; other site
325240009141	tetramer interface; other site
325240009142	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
325240009143	GAF domain; Region: GAF; pfam01590
325240009144	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
325240009145	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240009146	ATP binding site [chemical binding]; other site
325240009147	Mg2+ binding site [ion binding]; other site
325240009148	G-X-G motif; other site
325240009149	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
325240009150	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
325240009151	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
325240009152	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
325240009153	Zn2+ binding site [ion binding]; other site
325240009154	Mg2+ binding site [ion binding]; other site
325240009155	NlpE N-terminal domain; Region: NlpE; pfam04170
325240009156	HutD; Region: HutD; pfam05962
325240009157	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240009158	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240009159	Walker A motif; other site
325240009160	ATP binding site [chemical binding]; other site
325240009161	Walker B motif; other site
325240009162	Integrase core domain; Region: rve; pfam00665
325240009163	Integrase core domain; Region: rve; pfam00665
325240009164	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240009165	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240009166	Walker A motif; other site
325240009167	ATP binding site [chemical binding]; other site
325240009168	Walker B motif; other site
325240009169	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
325240009170	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
325240009171	NAD(P) binding site [chemical binding]; other site
325240009172	homodimer interface [polypeptide binding]; other site
325240009173	substrate binding site [chemical binding]; other site
325240009174	active site
325240009175	Bacterial sugar transferase; Region: Bac_transf; pfam02397
325240009176	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
325240009177	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
325240009178	putative NAD(P) binding site [chemical binding]; other site
325240009179	active site
325240009180	putative substrate binding site [chemical binding]; other site
325240009181	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
325240009182	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
325240009183	active site
325240009184	putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ; Provisional; Region: PRK09677
325240009185	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
325240009186	trimer interface [polypeptide binding]; other site
325240009187	active site
325240009188	substrate binding site [chemical binding]; other site
325240009189	CoA binding site [chemical binding]; other site
325240009190	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
325240009191	active site
325240009192	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
325240009193	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
325240009194	putative ADP-binding pocket [chemical binding]; other site
325240009195	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
325240009196	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
325240009197	Probable Catalytic site; other site
325240009198	metal-binding site
325240009199	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
325240009200	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
325240009201	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
325240009202	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
325240009203	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
325240009204	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
325240009205	NADP binding site [chemical binding]; other site
325240009206	active site
325240009207	putative substrate binding site [chemical binding]; other site
325240009208	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
325240009209	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
325240009210	substrate binding site; other site
325240009211	tetramer interface; other site
325240009212	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
325240009213	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
325240009214	NAD binding site [chemical binding]; other site
325240009215	substrate binding site [chemical binding]; other site
325240009216	homodimer interface [polypeptide binding]; other site
325240009217	active site
325240009218	Chain length determinant protein; Region: Wzz; pfam02706
325240009219	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
325240009220	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
325240009221	SLBB domain; Region: SLBB; pfam10531
325240009222	SLBB domain; Region: SLBB; pfam10531
325240009223	SLBB domain; Region: SLBB; pfam10531
325240009224	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
325240009225	SLBB domain; Region: SLBB; pfam10531
325240009226	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
325240009227	transcriptional activator RfaH; Region: RfaH; TIGR01955
325240009228	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
325240009229	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
325240009230	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240009231	putative substrate translocation pore; other site
325240009232	Response regulator receiver domain; Region: Response_reg; pfam00072
325240009233	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240009234	active site
325240009235	phosphorylation site [posttranslational modification]
325240009236	intermolecular recognition site; other site
325240009237	dimerization interface [polypeptide binding]; other site
325240009238	VacJ like lipoprotein; Region: VacJ; cl01073
325240009239	Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777
325240009240	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
325240009241	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
325240009242	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
325240009243	putative CheA interaction surface; other site
325240009244	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
325240009245	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
325240009246	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
325240009247	P-loop; other site
325240009248	Magnesium ion binding site [ion binding]; other site
325240009249	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
325240009250	Magnesium ion binding site [ion binding]; other site
325240009251	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
325240009252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240009253	active site
325240009254	phosphorylation site [posttranslational modification]
325240009255	intermolecular recognition site; other site
325240009256	CheB methylesterase; Region: CheB_methylest; pfam01339
325240009257	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
325240009258	putative binding surface; other site
325240009259	active site
325240009260	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
325240009261	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
325240009262	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240009263	ATP binding site [chemical binding]; other site
325240009264	Mg2+ binding site [ion binding]; other site
325240009265	G-X-G motif; other site
325240009266	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
325240009267	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
325240009268	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
325240009269	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240009270	active site
325240009271	phosphorylation site [posttranslational modification]
325240009272	intermolecular recognition site; other site
325240009273	dimerization interface [polypeptide binding]; other site
325240009274	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
325240009275	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
325240009276	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
325240009277	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
325240009278	DNA binding residues [nucleotide binding]
325240009279	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
325240009280	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
325240009281	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
325240009282	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
325240009283	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
325240009284	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
325240009285	FHIPEP family; Region: FHIPEP; pfam00771
325240009286	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
325240009287	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
325240009288	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
325240009289	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
325240009290	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
325240009291	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
325240009292	flagellar motor switch protein; Validated; Region: fliN; PRK08983
325240009293	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
325240009294	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
325240009295	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696
325240009296	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
325240009297	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
325240009298	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
325240009299	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08972
325240009300	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
325240009301	Walker A motif/ATP binding site; other site
325240009302	Walker B motif; other site
325240009303	flagellar assembly protein H; Validated; Region: fliH; PRK05687
325240009304	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
325240009305	Flagellar assembly protein FliH; Region: FliH; pfam02108
325240009306	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
325240009307	MgtE intracellular N domain; Region: MgtE_N; smart00924
325240009308	FliG C-terminal domain; Region: FliG_C; pfam01706
325240009309	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
325240009310	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
325240009311	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
325240009312	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
325240009313	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
325240009314	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240009315	active site
325240009316	phosphorylation site [posttranslational modification]
325240009317	intermolecular recognition site; other site
325240009318	dimerization interface [polypeptide binding]; other site
325240009319	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240009320	Walker A motif; other site
325240009321	ATP binding site [chemical binding]; other site
325240009322	Walker B motif; other site
325240009323	arginine finger; other site
325240009324	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
325240009325	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
325240009326	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240009327	putative active site [active]
325240009328	heme pocket [chemical binding]; other site
325240009329	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240009330	dimer interface [polypeptide binding]; other site
325240009331	phosphorylation site [posttranslational modification]
325240009332	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240009333	ATP binding site [chemical binding]; other site
325240009334	Mg2+ binding site [ion binding]; other site
325240009335	G-X-G motif; other site
325240009336	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
325240009337	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
325240009338	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240009339	Walker A motif; other site
325240009340	ATP binding site [chemical binding]; other site
325240009341	Walker B motif; other site
325240009342	arginine finger; other site
325240009343	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
325240009344	flagellar protein FliS; Validated; Region: fliS; PRK05685
325240009345	flagellar capping protein; Reviewed; Region: fliD; PRK08032
325240009346	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
325240009347	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
325240009348	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
325240009349	FlaG protein; Region: FlaG; pfam03646
325240009350	flagellin; Provisional; Region: PRK12802
325240009351	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
325240009352	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
325240009353	flagellin; Provisional; Region: PRK12802
325240009354	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
325240009355	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
325240009356	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
325240009357	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
325240009358	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08871
325240009359	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
325240009360	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
325240009361	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
325240009362	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
325240009363	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
325240009364	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
325240009365	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
325240009366	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
325240009367	Flagellar L-ring protein; Region: FlgH; pfam02107
325240009368	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
325240009369	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
325240009370	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
325240009371	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
325240009372	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
325240009373	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
325240009374	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
325240009375	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
325240009376	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
325240009377	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
325240009378	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
325240009379	flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12631
325240009380	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
325240009381	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
325240009382	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12625
325240009383	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
325240009384	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
325240009385	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
325240009386	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240009387	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
325240009388	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
325240009389	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240009390	active site
325240009391	phosphorylation site [posttranslational modification]
325240009392	intermolecular recognition site; other site
325240009393	dimerization interface [polypeptide binding]; other site
325240009394	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
325240009395	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
325240009396	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
325240009397	FlgN protein; Region: FlgN; pfam05130
325240009398	LPP20 lipoprotein; Region: LPP20; pfam02169
325240009399	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
325240009400	NeuB family; Region: NeuB; pfam03102
325240009401	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
325240009402	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
325240009403	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
325240009404	classical (c) SDRs; Region: SDR_c; cd05233
325240009405	NAD(P) binding site [chemical binding]; other site
325240009406	active site
325240009407	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
325240009408	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
325240009409	TPP-binding site; other site
325240009410	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
325240009411	PYR/PP interface [polypeptide binding]; other site
325240009412	dimer interface [polypeptide binding]; other site
325240009413	TPP binding site [chemical binding]; other site
325240009414	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
325240009415	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
325240009416	Methyltransferase domain; Region: Methyltransf_31; pfam13847
325240009417	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240009418	S-adenosylmethionine binding site [chemical binding]; other site
325240009419	Methyltransferase domain; Region: Methyltransf_23; pfam13489
325240009420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240009421	S-adenosylmethionine binding site [chemical binding]; other site
325240009422	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
325240009423	N-terminal catalytic domain of alpha-galactosidase; glycoside hydrolase family 57 (GH57); Region: GH57N_PfGalA_like; cd10794
325240009424	putative active site [active]
325240009425	catalytic site [active]
325240009426	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
325240009427	active site
325240009428	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
325240009429	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
325240009430	inhibitor-cofactor binding pocket; inhibition site
325240009431	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240009432	catalytic residue [active]
325240009433	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
325240009434	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
325240009435	NAD(P) binding site [chemical binding]; other site
325240009436	homodimer interface [polypeptide binding]; other site
325240009437	substrate binding site [chemical binding]; other site
325240009438	active site
325240009439	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
325240009440	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
325240009441	binding surface
325240009442	TPR motif; other site
325240009443	Protein of unknown function (DUF2947); Region: DUF2947; pfam11163
325240009444	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
325240009445	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
325240009446	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
325240009447	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
325240009448	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240009449	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
325240009450	Protein of unknown function (DUF465); Region: DUF465; pfam04325
325240009451	Cache domain; Region: Cache_1; pfam02743
325240009452	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240009453	dimerization interface [polypeptide binding]; other site
325240009454	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
325240009455	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240009456	dimer interface [polypeptide binding]; other site
325240009457	putative CheW interface [polypeptide binding]; other site
325240009458	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
325240009459	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
325240009460	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
325240009461	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
325240009462	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
325240009463	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
325240009464	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
325240009465	dimerization interface [polypeptide binding]; other site
325240009466	ATP binding site [chemical binding]; other site
325240009467	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
325240009468	dimerization interface [polypeptide binding]; other site
325240009469	ATP binding site [chemical binding]; other site
325240009470	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
325240009471	putative active site [active]
325240009472	catalytic triad [active]
325240009473	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
325240009474	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
325240009475	substrate binding pocket [chemical binding]; other site
325240009476	membrane-bound complex binding site; other site
325240009477	hinge residues; other site
325240009478	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
325240009479	N-acetyl-D-glucosamine binding site [chemical binding]; other site
325240009480	catalytic residue [active]
325240009481	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
325240009482	nucleoside/Zn binding site; other site
325240009483	dimer interface [polypeptide binding]; other site
325240009484	catalytic motif [active]
325240009485	GMP synthase; Reviewed; Region: guaA; PRK00074
325240009486	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
325240009487	AMP/PPi binding site [chemical binding]; other site
325240009488	candidate oxyanion hole; other site
325240009489	catalytic triad [active]
325240009490	potential glutamine specificity residues [chemical binding]; other site
325240009491	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
325240009492	ATP Binding subdomain [chemical binding]; other site
325240009493	Ligand Binding sites [chemical binding]; other site
325240009494	Dimerization subdomain; other site
325240009495	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
325240009496	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
325240009497	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
325240009498	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
325240009499	active site
325240009500	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
325240009501	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
325240009502	generic binding surface II; other site
325240009503	generic binding surface I; other site
325240009504	GTP-binding protein Der; Reviewed; Region: PRK00093
325240009505	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
325240009506	G1 box; other site
325240009507	GTP/Mg2+ binding site [chemical binding]; other site
325240009508	Switch I region; other site
325240009509	G2 box; other site
325240009510	Switch II region; other site
325240009511	G3 box; other site
325240009512	G4 box; other site
325240009513	G5 box; other site
325240009514	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
325240009515	G1 box; other site
325240009516	GTP/Mg2+ binding site [chemical binding]; other site
325240009517	Switch I region; other site
325240009518	G2 box; other site
325240009519	G3 box; other site
325240009520	Switch II region; other site
325240009521	G4 box; other site
325240009522	G5 box; other site
325240009523	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
325240009524	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
325240009525	Trp docking motif [polypeptide binding]; other site
325240009526	active site
325240009527	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
325240009528	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
325240009529	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
325240009530	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
325240009531	dimer interface [polypeptide binding]; other site
325240009532	motif 1; other site
325240009533	active site
325240009534	motif 2; other site
325240009535	motif 3; other site
325240009536	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
325240009537	anticodon binding site; other site
325240009538	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
325240009539	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
325240009540	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
325240009541	cytoskeletal protein RodZ; Provisional; Region: PRK10856
325240009542	Helix-turn-helix domain; Region: HTH_25; pfam13413
325240009543	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
325240009544	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
325240009545	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240009546	TPR motif; other site
325240009547	binding surface
325240009548	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240009549	binding surface
325240009550	TPR motif; other site
325240009551	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
325240009552	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
325240009553	FeS/SAM binding site; other site
325240009554	Domain of unknown function DUF21; Region: DUF21; pfam01595
325240009555	FOG: CBS domain [General function prediction only]; Region: COG0517
325240009556	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
325240009557	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
325240009558	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
325240009559	active site
325240009560	metal binding site [ion binding]; metal-binding site
325240009561	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
325240009562	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240009563	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
325240009564	The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which regulates expression of the heme uptake receptor HupA; contains the type 2 periplasmic binding fold; Region: PBP2_HupR; cd08431
325240009565	putative dimerization interface [polypeptide binding]; other site
325240009566	DoxX; Region: DoxX; pfam07681
325240009567	Pirin-related protein [General function prediction only]; Region: COG1741
325240009568	Pirin; Region: Pirin; pfam02678
325240009569	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
325240009570	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240009571	Coenzyme A binding pocket [chemical binding]; other site
325240009572	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
325240009573	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240009574	Coenzyme A binding pocket [chemical binding]; other site
325240009575	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
325240009576	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
325240009577	Coenzyme A binding pocket [chemical binding]; other site
325240009578	ParA-like protein; Provisional; Region: PHA02518
325240009579	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
325240009580	P-loop; other site
325240009581	Magnesium ion binding site [ion binding]; other site
325240009582	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
325240009583	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
325240009584	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240009585	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240009586	metal binding site [ion binding]; metal-binding site
325240009587	active site
325240009588	I-site; other site
325240009589	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
325240009590	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
325240009591	SnoaL-like domain; Region: SnoaL_3; pfam13474
325240009592	HDOD domain; Region: HDOD; pfam08668
325240009593	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
325240009594	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
325240009595	tetramer interface [polypeptide binding]; other site
325240009596	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240009597	catalytic residue [active]
325240009598	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
325240009599	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
325240009600	ligand binding site [chemical binding]; other site
325240009601	Conserved TM helix; Region: TM_helix; pfam05552
325240009602	mechanosensitive channel MscS; Provisional; Region: PRK10334
325240009603	Mechanosensitive ion channel; Region: MS_channel; pfam00924
325240009604	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
325240009605	dimer interface [polypeptide binding]; other site
325240009606	catalytic triad [active]
325240009607	peroxidatic and resolving cysteines [active]
325240009608	Predicted membrane protein [Function unknown]; Region: COG2860
325240009609	UPF0126 domain; Region: UPF0126; pfam03458
325240009610	UPF0126 domain; Region: UPF0126; pfam03458
325240009611	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
325240009612	translation initiation factor Sui1; Validated; Region: PRK06824
325240009613	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
325240009614	putative rRNA binding site [nucleotide binding]; other site
325240009615	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
325240009616	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
325240009617	ferrochelatase; Reviewed; Region: hemH; PRK00035
325240009618	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
325240009619	C-terminal domain interface [polypeptide binding]; other site
325240009620	active site
325240009621	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
325240009622	active site
325240009623	N-terminal domain interface [polypeptide binding]; other site
325240009624	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
325240009625	catalytic residues [active]
325240009626	dimer interface [polypeptide binding]; other site
325240009627	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
325240009628	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
325240009629	Walker A motif; other site
325240009630	ATP binding site [chemical binding]; other site
325240009631	Walker B motif; other site
325240009632	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
325240009633	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
325240009634	Walker A motif; other site
325240009635	ATP binding site [chemical binding]; other site
325240009636	Walker B motif; other site
325240009637	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
325240009638	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
325240009639	catalytic residue [active]
325240009640	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
325240009641	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
325240009642	YGGT family; Region: YGGT; pfam02325
325240009643	YGGT family; Region: YGGT; pfam02325
325240009644	hypothetical protein; Validated; Region: PRK05090
325240009645	Domain of unknown function (DUF4426); Region: DUF4426; pfam14467
325240009646	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
325240009647	active site
325240009648	dimerization interface [polypeptide binding]; other site
325240009649	HemN family oxidoreductase; Provisional; Region: PRK05660
325240009650	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
325240009651	FeS/SAM binding site; other site
325240009652	HemN C-terminal domain; Region: HemN_C; pfam06969
325240009653	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
325240009654	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
325240009655	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240009656	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240009657	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240009658	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
325240009659	putative effector binding pocket; other site
325240009660	dimerization interface [polypeptide binding]; other site
325240009661	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
325240009662	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
325240009663	glutaminase; Provisional; Region: PRK00971
325240009664	hypothetical protein; Provisional; Region: PRK11702
325240009665	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240009666	S-adenosylmethionine binding site [chemical binding]; other site
325240009667	adenine DNA glycosylase; Provisional; Region: PRK10880
325240009668	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
325240009669	minor groove reading motif; other site
325240009670	helix-hairpin-helix signature motif; other site
325240009671	substrate binding pocket [chemical binding]; other site
325240009672	active site
325240009673	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
325240009674	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
325240009675	DNA binding and oxoG recognition site [nucleotide binding]
325240009676	oxidative damage protection protein; Provisional; Region: PRK05408
325240009677	hypothetical protein; Provisional; Region: PRK03757
325240009678	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
325240009679	Protein of unknown function (DUF3634); Region: DUF3634; pfam12321
325240009680	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
325240009681	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
325240009682	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
325240009683	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240009684	S-adenosylmethionine binding site [chemical binding]; other site
325240009685	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
325240009686	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
325240009687	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
325240009688	hydroxyglutarate oxidase; Provisional; Region: PRK11728
325240009689	short chain dehydrogenase; Provisional; Region: PRK06101
325240009690	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
325240009691	NAD(P) binding site [chemical binding]; other site
325240009692	active site
325240009693	SnoaL-like domain; Region: SnoaL_2; pfam12680
325240009694	DNA photolyase; Region: DNA_photolyase; pfam00875
325240009695	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
325240009696	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
325240009697	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
325240009698	DNA binding residues [nucleotide binding]
325240009699	Protein of unknown function (DUF523); Region: DUF523; pfam04463
325240009700	Uncharacterized conserved protein [Function unknown]; Region: COG3272
325240009701	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
325240009702	Adenylosuccinate lyase C-terminus; Region: ADSL_C; cl17237
325240009703	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
325240009704	metal-binding site [ion binding]
325240009705	MerT mercuric transport protein; Region: MerT; cl03578
325240009706	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
325240009707	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
325240009708	Transposase; Region: HTH_Tnp_1; cl17663
325240009709	Winged helix-turn helix; Region: HTH_29; pfam13551
325240009710	Homeodomain-like domain; Region: HTH_32; pfam13565
325240009711	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
325240009712	Integrase core domain; Region: rve; pfam00665
325240009713	Integrase core domain; Region: rve_3; pfam13683
325240009714	Transposase; Region: HTH_Tnp_1; pfam01527
325240009715	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240009716	putative transposase OrfB; Reviewed; Region: PHA02517
325240009717	HTH-like domain; Region: HTH_21; pfam13276
325240009718	Integrase core domain; Region: rve; pfam00665
325240009719	Integrase core domain; Region: rve_2; pfam13333
325240009720	PBP superfamily domain; Region: PBP_like_2; cl17296
325240009721	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
325240009722	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
325240009723	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240009724	dimer interface [polypeptide binding]; other site
325240009725	putative CheW interface [polypeptide binding]; other site
325240009726	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
325240009727	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
325240009728	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
325240009729	homotrimer interaction site [polypeptide binding]; other site
325240009730	putative active site [active]
325240009731	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
325240009732	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
325240009733	YheO-like PAS domain; Region: PAS_6; pfam08348
325240009734	HTH domain; Region: HTH_22; pfam13309
325240009735	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
325240009736	Domain of unknown function (DUF368); Region: DUF368; pfam04018
325240009737	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
325240009738	CoenzymeA binding site [chemical binding]; other site
325240009739	subunit interaction site [polypeptide binding]; other site
325240009740	PHB binding site; other site
325240009741	purine nucleoside phosphorylase; Provisional; Region: PRK08202
325240009742	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
325240009743	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240009744	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
325240009745	putative dimerization interface [polypeptide binding]; other site
325240009746	putative substrate binding pocket [chemical binding]; other site
325240009747	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
325240009748	nucleoside/Zn binding site; other site
325240009749	dimer interface [polypeptide binding]; other site
325240009750	catalytic motif [active]
325240009751	Predicted membrane protein [Function unknown]; Region: COG2311
325240009752	Protein of unknown function (DUF418); Region: DUF418; cl12135
325240009753	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
325240009754	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
325240009755	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
325240009756	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
325240009757	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
325240009758	N-terminal Early set domain associated with the catalytic domain of chitinase; Region: E_set_Chitinase_N; cd02848
325240009759	Glyco_18 domain; Region: Glyco_18; smart00636
325240009760	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
325240009761	active site
325240009762	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
325240009763	aromatic chitin/cellulose binding site residues [chemical binding]; other site
325240009764	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
325240009765	aromatic chitin/cellulose binding site residues [chemical binding]; other site
325240009766	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
325240009767	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
325240009768	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
325240009769	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
325240009770	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
325240009771	active site
325240009772	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
325240009773	Zn2+ binding site [ion binding]; other site
325240009774	Mg2+ binding site [ion binding]; other site
325240009775	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240009776	PAS fold; Region: PAS_3; pfam08447
325240009777	putative active site [active]
325240009778	heme pocket [chemical binding]; other site
325240009779	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
325240009780	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240009781	dimer interface [polypeptide binding]; other site
325240009782	putative CheW interface [polypeptide binding]; other site
325240009783	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
325240009784	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
325240009785	ATP binding site [chemical binding]; other site
325240009786	Mg++ binding site [ion binding]; other site
325240009787	motif III; other site
325240009788	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240009789	nucleotide binding region [chemical binding]; other site
325240009790	ATP-binding site [chemical binding]; other site
325240009791	putrescine transporter; Provisional; Region: potE; PRK10655
325240009792	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
325240009793	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
325240009794	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
325240009795	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
325240009796	putative catalytic residues [active]
325240009797	Protein of unknown function (DUF2913); Region: DUF2913; pfam11140
325240009798	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
325240009799	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
325240009800	membrane-bound complex binding site; other site
325240009801	hinge residues; other site
325240009802	hypothetical protein; Provisional; Region: PRK09947
325240009803	putative oxidoreductase; Provisional; Region: PRK09849
325240009804	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
325240009805	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
325240009806	hypothetical protein; Provisional; Region: PRK09898
325240009807	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
325240009808	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
325240009809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
325240009810	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
325240009811	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
325240009812	DsrE/DsrF-like family; Region: DrsE; pfam02635
325240009813	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
325240009814	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
325240009815	active site
325240009816	Zn binding site [ion binding]; other site
325240009817	Protein of unknown function, DUF486; Region: DUF486; pfam04342
325240009818	Protein of unknown function (DUF2960); Region: DUF2960; pfam11173
325240009819	RDD family; Region: RDD; pfam06271
325240009820	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
325240009821	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
325240009822	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
325240009823	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
325240009824	multifunctional aminopeptidase A; Provisional; Region: PRK00913
325240009825	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
325240009826	interface (dimer of trimers) [polypeptide binding]; other site
325240009827	Substrate-binding/catalytic site; other site
325240009828	Zn-binding sites [ion binding]; other site
325240009829	PAS domain S-box; Region: sensory_box; TIGR00229
325240009830	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240009831	putative active site [active]
325240009832	heme pocket [chemical binding]; other site
325240009833	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240009834	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240009835	metal binding site [ion binding]; metal-binding site
325240009836	active site
325240009837	I-site; other site
325240009838	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
325240009839	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
325240009840	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
325240009841	HIGH motif; other site
325240009842	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
325240009843	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
325240009844	active site
325240009845	KMSKS motif; other site
325240009846	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
325240009847	tRNA binding surface [nucleotide binding]; other site
325240009848	anticodon binding site; other site
325240009849	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
325240009850	carbon storage regulator; Provisional; Region: PRK01712
325240009851	aspartate kinase; Reviewed; Region: PRK06635
325240009852	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
325240009853	putative nucleotide binding site [chemical binding]; other site
325240009854	putative catalytic residues [active]
325240009855	putative Mg ion binding site [ion binding]; other site
325240009856	putative aspartate binding site [chemical binding]; other site
325240009857	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
325240009858	putative allosteric regulatory residue; other site
325240009859	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
325240009860	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
325240009861	motif 1; other site
325240009862	active site
325240009863	motif 2; other site
325240009864	motif 3; other site
325240009865	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
325240009866	DHHA1 domain; Region: DHHA1; pfam02272
325240009867	RecX family; Region: RecX; pfam02631
325240009868	recombinase A; Provisional; Region: recA; PRK09354
325240009869	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
325240009870	hexamer interface [polypeptide binding]; other site
325240009871	Walker A motif; other site
325240009872	ATP binding site [chemical binding]; other site
325240009873	Walker B motif; other site
325240009874	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
325240009875	MutS domain I; Region: MutS_I; pfam01624
325240009876	MutS domain II; Region: MutS_II; pfam05188
325240009877	MutS domain III; Region: MutS_III; pfam05192
325240009878	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
325240009879	Walker A/P-loop; other site
325240009880	ATP binding site [chemical binding]; other site
325240009881	Q-loop/lid; other site
325240009882	ABC transporter signature motif; other site
325240009883	Walker B; other site
325240009884	D-loop; other site
325240009885	H-loop/switch region; other site
325240009886	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
325240009887	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
325240009888	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
325240009889	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
325240009890	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
325240009891	DNA binding residues [nucleotide binding]
325240009892	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
325240009893	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
325240009894	Peptidase family M23; Region: Peptidase_M23; pfam01551
325240009895	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
325240009896	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240009897	S-adenosylmethionine binding site [chemical binding]; other site
325240009898	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
325240009899	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
325240009900	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
325240009901	Permutation of conserved domain; other site
325240009902	active site
325240009903	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
325240009904	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
325240009905	homotrimer interaction site [polypeptide binding]; other site
325240009906	zinc binding site [ion binding]; other site
325240009907	CDP-binding sites; other site
325240009908	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
325240009909	substrate binding site; other site
325240009910	dimer interface; other site
325240009911	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
325240009912	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
325240009913	enolase; Provisional; Region: eno; PRK00077
325240009914	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
325240009915	dimer interface [polypeptide binding]; other site
325240009916	metal binding site [ion binding]; metal-binding site
325240009917	substrate binding pocket [chemical binding]; other site
325240009918	CTP synthetase; Validated; Region: pyrG; PRK05380
325240009919	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
325240009920	Catalytic site [active]
325240009921	active site
325240009922	UTP binding site [chemical binding]; other site
325240009923	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
325240009924	active site
325240009925	putative oxyanion hole; other site
325240009926	catalytic triad [active]
325240009927	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
325240009928	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
325240009929	homodimer interface [polypeptide binding]; other site
325240009930	metal binding site [ion binding]; metal-binding site
325240009931	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
325240009932	homodimer interface [polypeptide binding]; other site
325240009933	active site
325240009934	putative chemical substrate binding site [chemical binding]; other site
325240009935	metal binding site [ion binding]; metal-binding site
325240009936	agmatine deiminase; Provisional; Region: PRK13551
325240009937	agmatine deiminase; Region: agmatine_aguA; TIGR03380
325240009938	amidase; Validated; Region: PRK06565
325240009939	Amidase; Region: Amidase; cl11426
325240009940	Amidase; Region: Amidase; cl11426
325240009941	methionine synthase; Provisional; Region: PRK01207
325240009942	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
325240009943	substrate binding site [chemical binding]; other site
325240009944	THF binding site; other site
325240009945	zinc-binding site [ion binding]; other site
325240009946	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
325240009947	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
325240009948	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
325240009949	putative active site [active]
325240009950	putative NTP binding site [chemical binding]; other site
325240009951	putative nucleic acid binding site [nucleotide binding]; other site
325240009952	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
325240009953	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240009954	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240009955	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240009956	Walker A motif; other site
325240009957	ATP binding site [chemical binding]; other site
325240009958	Walker B motif; other site
325240009959	Helix-turn-helix domain; Region: HTH_28; pfam13518
325240009960	Winged helix-turn helix; Region: HTH_29; pfam13551
325240009961	Homeodomain-like domain; Region: HTH_32; pfam13565
325240009962	Integrase core domain; Region: rve; pfam00665
325240009963	DDE domain; Region: DDE_Tnp_IS240; pfam13610
325240009964	Integrase core domain; Region: rve_3; pfam13683
325240009965	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
325240009966	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240009967	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
325240009968	HD domain; Region: HD_4; pfam13328
325240009969	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
325240009970	synthetase active site [active]
325240009971	NTP binding site [chemical binding]; other site
325240009972	metal binding site [ion binding]; metal-binding site
325240009973	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
325240009974	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
325240009975	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
325240009976	TRAM domain; Region: TRAM; pfam01938
325240009977	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240009978	S-adenosylmethionine binding site [chemical binding]; other site
325240009979	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
325240009980	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
325240009981	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240009982	dimerization interface [polypeptide binding]; other site
325240009983	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240009984	dimer interface [polypeptide binding]; other site
325240009985	phosphorylation site [posttranslational modification]
325240009986	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240009987	ATP binding site [chemical binding]; other site
325240009988	Mg2+ binding site [ion binding]; other site
325240009989	G-X-G motif; other site
325240009990	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240009991	active site
325240009992	phosphorylation site [posttranslational modification]
325240009993	intermolecular recognition site; other site
325240009994	dimerization interface [polypeptide binding]; other site
325240009995	Hpt domain; Region: Hpt; pfam01627
325240009996	Protein of unknown function (DUF416); Region: DUF416; pfam04222
325240009997	Protein of unknown function (DUF3319); Region: DUF3319; pfam11782
325240009998	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240009999	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240010000	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
325240010001	putative effector binding pocket; other site
325240010002	dimerization interface [polypeptide binding]; other site
325240010003	Membrane transport protein; Region: Mem_trans; cl09117
325240010004	recombination and repair protein; Provisional; Region: PRK10869
325240010005	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
325240010006	Walker A/P-loop; other site
325240010007	ATP binding site [chemical binding]; other site
325240010008	Q-loop/lid; other site
325240010009	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
325240010010	ABC transporter signature motif; other site
325240010011	Walker B; other site
325240010012	D-loop; other site
325240010013	H-loop/switch region; other site
325240010014	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
325240010015	tetramer interfaces [polypeptide binding]; other site
325240010016	binuclear metal-binding site [ion binding]; other site
325240010017	thiamine monophosphate kinase; Provisional; Region: PRK05731
325240010018	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
325240010019	ATP binding site [chemical binding]; other site
325240010020	dimerization interface [polypeptide binding]; other site
325240010021	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
325240010022	putative RNA binding site [nucleotide binding]; other site
325240010023	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
325240010024	homopentamer interface [polypeptide binding]; other site
325240010025	active site
325240010026	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
325240010027	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
325240010028	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
325240010029	dimerization interface [polypeptide binding]; other site
325240010030	active site
325240010031	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
325240010032	Lumazine binding domain; Region: Lum_binding; pfam00677
325240010033	Lumazine binding domain; Region: Lum_binding; pfam00677
325240010034	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
325240010035	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
325240010036	catalytic motif [active]
325240010037	Zn binding site [ion binding]; other site
325240010038	RibD C-terminal domain; Region: RibD_C; cl17279
325240010039	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
325240010040	ATP cone domain; Region: ATP-cone; pfam03477
325240010041	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
325240010042	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
325240010043	dimer interface [polypeptide binding]; other site
325240010044	active site
325240010045	glycine-pyridoxal phosphate binding site [chemical binding]; other site
325240010046	folate binding site [chemical binding]; other site
325240010047	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
325240010048	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
325240010049	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
325240010050	ABC transporter; Region: ABC_tran_2; pfam12848
325240010051	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
325240010052	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240010053	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240010054	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
325240010055	putative effector binding pocket; other site
325240010056	dimerization interface [polypeptide binding]; other site
325240010057	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
325240010058	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
325240010059	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
325240010060	catalytic residues [active]
325240010061	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
325240010062	Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425
325240010063	active site
325240010064	metal binding site [ion binding]; metal-binding site
325240010065	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
325240010066	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
325240010067	substrate binding pocket [chemical binding]; other site
325240010068	membrane-bound complex binding site; other site
325240010069	hinge residues; other site
325240010070	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
325240010071	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
325240010072	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240010073	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
325240010074	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240010075	putative substrate translocation pore; other site
325240010076	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
325240010077	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
325240010078	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
325240010079	EamA-like transporter family; Region: EamA; pfam00892
325240010080	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
325240010081	EamA-like transporter family; Region: EamA; pfam00892
325240010082	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
325240010083	Uncharacterized conserved protein [Function unknown]; Region: COG1432
325240010084	LabA_like proteins; Region: LabA_like/DUF88; cl10034
325240010085	putative metal binding site [ion binding]; other site
325240010086	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
325240010087	apolar tunnel; other site
325240010088	heme binding site [chemical binding]; other site
325240010089	dimerization interface [polypeptide binding]; other site
325240010090	Protein of unknown function (DUF3034); Region: DUF3034; pfam11231
325240010091	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240010092	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240010093	metal binding site [ion binding]; metal-binding site
325240010094	active site
325240010095	I-site; other site
325240010096	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240010097	Cna protein B-type domain; Region: Cna_B; pfam05738
325240010098	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
325240010099	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
325240010100	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
325240010101	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240010102	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
325240010103	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
325240010104	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240010105	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240010106	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
325240010107	dimerization interface [polypeptide binding]; other site
325240010108	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240010109	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240010110	Walker A motif; other site
325240010111	ATP binding site [chemical binding]; other site
325240010112	Walker B motif; other site
325240010113	Integrase core domain; Region: rve; pfam00665
325240010114	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
325240010115	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
325240010116	putative transposase OrfB; Reviewed; Region: PHA02517
325240010117	HTH-like domain; Region: HTH_21; pfam13276
325240010118	Integrase core domain; Region: rve; pfam00665
325240010119	Integrase core domain; Region: rve_2; pfam13333
325240010120	Transposase; Region: HTH_Tnp_1; pfam01527
325240010121	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240010122	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
325240010123	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
325240010124	substrate binding pocket [chemical binding]; other site
325240010125	membrane-bound complex binding site; other site
325240010126	hinge residues; other site
325240010127	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240010128	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240010129	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
325240010130	dimerization interface [polypeptide binding]; other site
325240010131	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
325240010132	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
325240010133	GDP-binding site [chemical binding]; other site
325240010134	ACT binding site; other site
325240010135	IMP binding site; other site
325240010136	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
325240010137	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
325240010138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240010139	active site
325240010140	phosphorylation site [posttranslational modification]
325240010141	intermolecular recognition site; other site
325240010142	dimerization interface [polypeptide binding]; other site
325240010143	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
325240010144	active site
325240010145	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240010146	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240010147	metal binding site [ion binding]; metal-binding site
325240010148	active site
325240010149	I-site; other site
325240010150	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240010151	HDOD domain; Region: HDOD; pfam08668
325240010152	putative protease; Provisional; Region: PRK15452
325240010153	Peptidase family U32; Region: Peptidase_U32; pfam01136
325240010154	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
325240010155	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
325240010156	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
325240010157	calcium binding site 2 [ion binding]; other site
325240010158	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
325240010159	active site
325240010160	catalytic triad [active]
325240010161	calcium binding site 1 [ion binding]; other site
325240010162	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
325240010163	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
325240010164	SCP-2 sterol transfer family; Region: SCP2; cl01225
325240010165	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
325240010166	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
325240010167	Peptidase family U32; Region: Peptidase_U32; pfam01136
325240010168	putative protease; Provisional; Region: PRK15447
325240010169	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
325240010170	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
325240010171	Nucleoside recognition; Region: Gate; pfam07670
325240010172	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
325240010173	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
325240010174	putative active site [active]
325240010175	putative metal binding site [ion binding]; other site
325240010176	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
325240010177	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
325240010178	putative acyl-acceptor binding pocket; other site
325240010179	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
325240010180	FOG: CBS domain [General function prediction only]; Region: COG0517
325240010181	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_24; cd04637
325240010182	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
325240010183	Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796
325240010184	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
325240010185	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
325240010186	chaperone protein TorD; Validated; Region: torD; PRK04976
325240010187	TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956
325240010188	HAMP domain; Region: HAMP; pfam00672
325240010189	dimerization interface [polypeptide binding]; other site
325240010190	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240010191	dimer interface [polypeptide binding]; other site
325240010192	phosphorylation site [posttranslational modification]
325240010193	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240010194	ATP binding site [chemical binding]; other site
325240010195	Mg2+ binding site [ion binding]; other site
325240010196	G-X-G motif; other site
325240010197	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240010198	active site
325240010199	phosphorylation site [posttranslational modification]
325240010200	intermolecular recognition site; other site
325240010201	dimerization interface [polypeptide binding]; other site
325240010202	TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936
325240010203	TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306
325240010204	putative ligand binding site [chemical binding]; other site
325240010205	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
325240010206	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240010207	active site
325240010208	phosphorylation site [posttranslational modification]
325240010209	intermolecular recognition site; other site
325240010210	dimerization interface [polypeptide binding]; other site
325240010211	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
325240010212	DNA binding site [nucleotide binding]
325240010213	PilZ domain; Region: PilZ; pfam07238
325240010214	DNA repair protein RadA; Provisional; Region: PRK11823
325240010215	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
325240010216	Walker A motif/ATP binding site; other site
325240010217	ATP binding site [chemical binding]; other site
325240010218	Walker B motif; other site
325240010219	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
325240010220	PilZ domain; Region: PilZ; pfam07238
325240010221	PilZ domain; Region: PilZ; pfam07238
325240010222	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
325240010223	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
325240010224	phosphoserine phosphatase SerB; Region: serB; TIGR00338
325240010225	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
325240010226	motif II; other site
325240010227	Bacterial virulence factor haemolysin; Region: SMP_2; cl11479
325240010228	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
325240010229	phosphopentomutase; Provisional; Region: PRK05362
325240010230	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
325240010231	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
325240010232	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
325240010233	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
325240010234	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
325240010235	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
325240010236	intersubunit interface [polypeptide binding]; other site
325240010237	active site
325240010238	catalytic residue [active]
325240010239	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
325240010240	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
325240010241	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
325240010242	Nucleoside recognition; Region: Gate; pfam07670
325240010243	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
325240010244	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
325240010245	active site
325240010246	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
325240010247	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
325240010248	G1 box; other site
325240010249	putative GEF interaction site [polypeptide binding]; other site
325240010250	GTP/Mg2+ binding site [chemical binding]; other site
325240010251	Switch I region; other site
325240010252	G2 box; other site
325240010253	G3 box; other site
325240010254	Switch II region; other site
325240010255	G4 box; other site
325240010256	G5 box; other site
325240010257	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
325240010258	lipoprotein NlpI; Provisional; Region: PRK11189
325240010259	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240010260	binding surface
325240010261	TPR motif; other site
325240010262	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
325240010263	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
325240010264	RNase E interface [polypeptide binding]; other site
325240010265	trimer interface [polypeptide binding]; other site
325240010266	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
325240010267	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
325240010268	RNase E interface [polypeptide binding]; other site
325240010269	trimer interface [polypeptide binding]; other site
325240010270	active site
325240010271	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
325240010272	putative nucleic acid binding region [nucleotide binding]; other site
325240010273	G-X-X-G motif; other site
325240010274	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
325240010275	RNA binding site [nucleotide binding]; other site
325240010276	domain interface; other site
325240010277	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240010278	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240010279	metal binding site [ion binding]; metal-binding site
325240010280	active site
325240010281	I-site; other site
325240010282	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240010283	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
325240010284	16S/18S rRNA binding site [nucleotide binding]; other site
325240010285	S13e-L30e interaction site [polypeptide binding]; other site
325240010286	25S rRNA binding site [nucleotide binding]; other site
325240010287	Ribosomal S15 leader as predicted by Rfam (RF00114), score 60.75
325240010288	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
325240010289	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
325240010290	RNA binding site [nucleotide binding]; other site
325240010291	active site
325240010292	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
325240010293	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
325240010294	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
325240010295	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
325240010296	translation initiation factor IF-2; Region: IF-2; TIGR00487
325240010297	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
325240010298	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
325240010299	G1 box; other site
325240010300	putative GEF interaction site [polypeptide binding]; other site
325240010301	GTP/Mg2+ binding site [chemical binding]; other site
325240010302	Switch I region; other site
325240010303	G2 box; other site
325240010304	G3 box; other site
325240010305	Switch II region; other site
325240010306	G4 box; other site
325240010307	G5 box; other site
325240010308	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
325240010309	Translation-initiation factor 2; Region: IF-2; pfam11987
325240010310	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
325240010311	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
325240010312	NusA N-terminal domain; Region: NusA_N; pfam08529
325240010313	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
325240010314	RNA binding site [nucleotide binding]; other site
325240010315	homodimer interface [polypeptide binding]; other site
325240010316	NusA-like KH domain; Region: KH_5; pfam13184
325240010317	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
325240010318	G-X-X-G motif; other site
325240010319	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
325240010320	ribosome maturation protein RimP; Reviewed; Region: PRK00092
325240010321	Sm and related proteins; Region: Sm_like; cl00259
325240010322	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
325240010323	putative oligomer interface [polypeptide binding]; other site
325240010324	putative RNA binding site [nucleotide binding]; other site
325240010325	Preprotein translocase SecG subunit; Region: SecG; pfam03840
325240010326	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
325240010327	triosephosphate isomerase; Provisional; Region: PRK14567
325240010328	substrate binding site [chemical binding]; other site
325240010329	dimer interface [polypeptide binding]; other site
325240010330	catalytic triad [active]
325240010331	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
325240010332	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
325240010333	active site
325240010334	substrate binding site [chemical binding]; other site
325240010335	metal binding site [ion binding]; metal-binding site
325240010336	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
325240010337	dihydropteroate synthase; Region: DHPS; TIGR01496
325240010338	substrate binding pocket [chemical binding]; other site
325240010339	dimer interface [polypeptide binding]; other site
325240010340	inhibitor binding site; inhibition site
325240010341	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
325240010342	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240010343	Walker A motif; other site
325240010344	ATP binding site [chemical binding]; other site
325240010345	Walker B motif; other site
325240010346	arginine finger; other site
325240010347	Peptidase family M41; Region: Peptidase_M41; pfam01434
325240010348	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
325240010349	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240010350	S-adenosylmethionine binding site [chemical binding]; other site
325240010351	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
325240010352	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13021
325240010353	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
325240010354	Protein export membrane protein; Region: SecD_SecF; pfam02355
325240010355	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK12933
325240010356	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
325240010357	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
325240010358	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
325240010359	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
325240010360	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
325240010361	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
325240010362	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
325240010363	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
325240010364	GTP-binding protein YchF; Reviewed; Region: PRK09601
325240010365	YchF GTPase; Region: YchF; cd01900
325240010366	G1 box; other site
325240010367	GTP/Mg2+ binding site [chemical binding]; other site
325240010368	Switch I region; other site
325240010369	G2 box; other site
325240010370	Switch II region; other site
325240010371	G3 box; other site
325240010372	G4 box; other site
325240010373	G5 box; other site
325240010374	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
325240010375	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
325240010376	putative active site [active]
325240010377	catalytic residue [active]
325240010378	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK08849
325240010379	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
325240010380	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
325240010381	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
325240010382	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
325240010383	FeS/SAM binding site; other site
325240010384	TRAM domain; Region: TRAM; pfam01938
325240010385	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
325240010386	PhoH-like protein; Region: PhoH; pfam02562
325240010387	metal-binding heat shock protein; Provisional; Region: PRK00016
325240010388	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
325240010389	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
325240010390	Transporter associated domain; Region: CorC_HlyC; smart01091
325240010391	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
325240010392	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
325240010393	putative active site [active]
325240010394	catalytic triad [active]
325240010395	putative dimer interface [polypeptide binding]; other site
325240010396	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240010397	S-adenosylmethionine binding site [chemical binding]; other site
325240010398	Protein of unknown function (DUF1451); Region: DUF1451; pfam07295
325240010399	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
325240010400	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
325240010401	HIGH motif; other site
325240010402	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
325240010403	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
325240010404	active site
325240010405	KMSKS motif; other site
325240010406	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
325240010407	tRNA binding surface [nucleotide binding]; other site
325240010408	Lipopolysaccharide-assembly; Region: LptE; cl01125
325240010409	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
325240010410	DNA polymerase III, delta subunit; Region: holA; TIGR01128
325240010411	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
325240010412	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
325240010413	active site
325240010414	(T/H)XGH motif; other site
325240010415	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
325240010416	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
325240010417	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
325240010418	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
325240010419	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
325240010420	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
325240010421	Transglycosylase SLT domain; Region: SLT_2; pfam13406
325240010422	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
325240010423	N-acetyl-D-glucosamine binding site [chemical binding]; other site
325240010424	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
325240010425	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
325240010426	Sporulation related domain; Region: SPOR; pfam05036
325240010427	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
325240010428	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
325240010429	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
325240010430	hypothetical protein; Provisional; Region: PRK04998
325240010431	lipoate-protein ligase B; Provisional; Region: PRK14342
325240010432	lipoyl synthase; Provisional; Region: PRK05481
325240010433	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
325240010434	FeS/SAM binding site; other site
325240010435	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
325240010436	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
325240010437	DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436
325240010438	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
325240010439	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
325240010440	dimerization interface [polypeptide binding]; other site
325240010441	DPS ferroxidase diiron center [ion binding]; other site
325240010442	ion pore; other site
325240010443	Predicted membrane protein [Function unknown]; Region: COG3503
325240010444	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
325240010445	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
325240010446	N-terminal plug; other site
325240010447	ligand-binding site [chemical binding]; other site
325240010448	SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102
325240010449	SEC-C motif; Region: SEC-C; pfam02810
325240010450	DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141
325240010451	catalytic site [active]
325240010452	putative active site [active]
325240010453	putative substrate binding site [chemical binding]; other site
325240010454	Protein of unknown function (DUF808); Region: DUF808; pfam05661
325240010455	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
325240010456	tetramer (dimer of dimers) interface [polypeptide binding]; other site
325240010457	active site
325240010458	dimer interface [polypeptide binding]; other site
325240010459	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
325240010460	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
325240010461	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
325240010462	putative RNA binding site [nucleotide binding]; other site
325240010463	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240010464	S-adenosylmethionine binding site [chemical binding]; other site
325240010465	Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366
325240010466	Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366
325240010467	hypothetical protein; Provisional; Region: PRK05409
325240010468	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
325240010469	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
325240010470	putative metal binding site [ion binding]; other site
325240010471	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
325240010472	putative catalytic site [active]
325240010473	putative phosphate binding site [ion binding]; other site
325240010474	putative metal binding site [ion binding]; other site
325240010475	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
325240010476	MgtE intracellular N domain; Region: MgtE_N; pfam03448
325240010477	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
325240010478	Divalent cation transporter; Region: MgtE; pfam01769
325240010479	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240010480	dimer interface [polypeptide binding]; other site
325240010481	putative CheW interface [polypeptide binding]; other site
325240010482	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
325240010483	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
325240010484	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
325240010485	substrate binding pocket [chemical binding]; other site
325240010486	membrane-bound complex binding site; other site
325240010487	hinge residues; other site
325240010488	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
325240010489	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
325240010490	active site
325240010491	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
325240010492	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
325240010493	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
325240010494	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
325240010495	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
325240010496	ATP-grasp domain; Region: ATP-grasp_4; cl17255
325240010497	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
325240010498	IMP binding site; other site
325240010499	dimer interface [polypeptide binding]; other site
325240010500	interdomain contacts; other site
325240010501	partial ornithine binding site; other site
325240010502	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
325240010503	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
325240010504	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
325240010505	catalytic site [active]
325240010506	subunit interface [polypeptide binding]; other site
325240010507	dihydrodipicolinate reductase; Provisional; Region: PRK00048
325240010508	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
325240010509	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
325240010510	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
325240010511	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
325240010512	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
325240010513	Peptidase family M48; Region: Peptidase_M48; pfam01435
325240010514	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
325240010515	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
325240010516	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
325240010517	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
325240010518	ATP binding site [chemical binding]; other site
325240010519	putative Mg++ binding site [ion binding]; other site
325240010520	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240010521	nucleotide binding region [chemical binding]; other site
325240010522	ATP-binding site [chemical binding]; other site
325240010523	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240010524	Transposase; Region: HTH_Tnp_1; pfam01527
325240010525	putative transposase OrfB; Reviewed; Region: PHA02517
325240010526	HTH-like domain; Region: HTH_21; pfam13276
325240010527	Integrase core domain; Region: rve; pfam00665
325240010528	Integrase core domain; Region: rve_3; pfam13683
325240010529	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
325240010530	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
325240010531	chaperone protein DnaJ; Provisional; Region: PRK10767
325240010532	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
325240010533	HSP70 interaction site [polypeptide binding]; other site
325240010534	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
325240010535	substrate binding site [polypeptide binding]; other site
325240010536	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
325240010537	Zn binding sites [ion binding]; other site
325240010538	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
325240010539	dimer interface [polypeptide binding]; other site
325240010540	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
325240010541	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
325240010542	nucleotide binding site [chemical binding]; other site
325240010543	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
325240010544	EamA-like transporter family; Region: EamA; pfam00892
325240010545	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
325240010546	putative deacylase active site [active]
325240010547	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
325240010548	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
325240010549	putative catalytic cysteine [active]
325240010550	gamma-glutamyl kinase; Provisional; Region: PRK05429
325240010551	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
325240010552	nucleotide binding site [chemical binding]; other site
325240010553	homotetrameric interface [polypeptide binding]; other site
325240010554	putative phosphate binding site [ion binding]; other site
325240010555	putative allosteric binding site; other site
325240010556	PUA domain; Region: PUA; pfam01472
325240010557	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
325240010558	Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; pfam09904
325240010559	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
325240010560	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
325240010561	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
325240010562	membrane-bound complex binding site; other site
325240010563	hinge residues; other site
325240010564	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
325240010565	Ligand Binding Site [chemical binding]; other site
325240010566	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
325240010567	Ligand Binding Site [chemical binding]; other site
325240010568	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
325240010569	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
325240010570	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
325240010571	NAD(P) binding site [chemical binding]; other site
325240010572	catalytic residues [active]
325240010573	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
325240010574	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
325240010575	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
325240010576	Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082
325240010577	Curli assembly protein CsgE; Region: CsgE; pfam10627
325240010578	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
325240010579	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240010580	ATP binding site [chemical binding]; other site
325240010581	Mg2+ binding site [ion binding]; other site
325240010582	G-X-G motif; other site
325240010583	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
325240010584	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240010585	active site
325240010586	phosphorylation site [posttranslational modification]
325240010587	intermolecular recognition site; other site
325240010588	dimerization interface [polypeptide binding]; other site
325240010589	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240010590	Walker A motif; other site
325240010591	ATP binding site [chemical binding]; other site
325240010592	Walker B motif; other site
325240010593	arginine finger; other site
325240010594	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
325240010595	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
325240010596	FtsX-like permease family; Region: FtsX; pfam02687
325240010597	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
325240010598	FtsX-like permease family; Region: FtsX; pfam02687
325240010599	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
325240010600	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
325240010601	Walker A/P-loop; other site
325240010602	ATP binding site [chemical binding]; other site
325240010603	Q-loop/lid; other site
325240010604	ABC transporter signature motif; other site
325240010605	Walker B; other site
325240010606	D-loop; other site
325240010607	H-loop/switch region; other site
325240010608	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
325240010609	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
325240010610	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240010611	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
325240010612	active site
325240010613	substrate binding pocket [chemical binding]; other site
325240010614	dimer interface [polypeptide binding]; other site
325240010615	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
325240010616	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
325240010617	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
325240010618	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240010619	Coenzyme A binding pocket [chemical binding]; other site
325240010620	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
325240010621	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
325240010622	DNA-binding site [nucleotide binding]; DNA binding site
325240010623	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
325240010624	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240010625	homodimer interface [polypeptide binding]; other site
325240010626	catalytic residue [active]
325240010627	MAPEG family; Region: MAPEG; cl09190
325240010628	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240010629	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
325240010630	Coenzyme A binding pocket [chemical binding]; other site
325240010631	AAA domain; Region: AAA_33; pfam13671
325240010632	AAA domain; Region: AAA_17; pfam13207
325240010633	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
325240010634	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
325240010635	dimer interface [polypeptide binding]; other site
325240010636	active site
325240010637	metal binding site [ion binding]; metal-binding site
325240010638	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
325240010639	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
325240010640	NAD(P) binding site [chemical binding]; other site
325240010641	catalytic residues [active]
325240010642	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
325240010643	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
325240010644	cobalamin binding residues [chemical binding]; other site
325240010645	putative BtuC binding residues; other site
325240010646	dimer interface [polypeptide binding]; other site
325240010647	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
325240010648	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
325240010649	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
325240010650	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
325240010651	homodimer interface [polypeptide binding]; other site
325240010652	Walker A motif; other site
325240010653	ATP binding site [chemical binding]; other site
325240010654	hydroxycobalamin binding site [chemical binding]; other site
325240010655	Walker B motif; other site
325240010656	cobyric acid synthase; Provisional; Region: PRK00784
325240010657	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
325240010658	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
325240010659	catalytic triad [active]
325240010660	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
325240010661	homotrimer interface [polypeptide binding]; other site
325240010662	Walker A motif; other site
325240010663	GTP binding site [chemical binding]; other site
325240010664	Walker B motif; other site
325240010665	cobalamin synthase; Reviewed; Region: cobS; PRK00235
325240010666	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
325240010667	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
325240010668	putative dimer interface [polypeptide binding]; other site
325240010669	active site pocket [active]
325240010670	putative cataytic base [active]
325240010671	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
325240010672	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
325240010673	ABC-ATPase subunit  interface; other site
325240010674	dimer interface [polypeptide binding]; other site
325240010675	putative PBP binding regions; other site
325240010676	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
325240010677	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
325240010678	Walker A/P-loop; other site
325240010679	ATP binding site [chemical binding]; other site
325240010680	Q-loop/lid; other site
325240010681	ABC transporter signature motif; other site
325240010682	Walker B; other site
325240010683	D-loop; other site
325240010684	H-loop/switch region; other site
325240010685	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
325240010686	catalytic core [active]
325240010687	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
325240010688	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
325240010689	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
325240010690	substrate binding pocket [chemical binding]; other site
325240010691	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
325240010692	B12 binding site [chemical binding]; other site
325240010693	cobalt ligand [ion binding]; other site
325240010694	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
325240010695	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240010696	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240010697	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
325240010698	putative effector binding pocket; other site
325240010699	dimerization interface [polypeptide binding]; other site
325240010700	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
325240010701	classical (c) SDRs; Region: SDR_c; cd05233
325240010702	NAD(P) binding site [chemical binding]; other site
325240010703	active site
325240010704	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240010705	PAS domain; Region: PAS_9; pfam13426
325240010706	putative active site [active]
325240010707	heme pocket [chemical binding]; other site
325240010708	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240010709	PAS domain; Region: PAS_9; pfam13426
325240010710	putative active site [active]
325240010711	heme pocket [chemical binding]; other site
325240010712	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240010713	dimer interface [polypeptide binding]; other site
325240010714	putative CheW interface [polypeptide binding]; other site
325240010715	Uncharacterized conserved protein [Function unknown]; Region: COG1479
325240010716	Protein of unknown function DUF262; Region: DUF262; pfam03235
325240010717	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
325240010718	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
325240010719	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
325240010720	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
325240010721	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
325240010722	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
325240010723	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
325240010724	Cytochrome c; Region: Cytochrom_C; pfam00034
325240010725	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
325240010726	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
325240010727	Cytochrome c; Region: Cytochrom_C; pfam00034
325240010728	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240010729	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
325240010730	putative active site [active]
325240010731	heme pocket [chemical binding]; other site
325240010732	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240010733	putative active site [active]
325240010734	heme pocket [chemical binding]; other site
325240010735	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240010736	dimer interface [polypeptide binding]; other site
325240010737	putative CheW interface [polypeptide binding]; other site
325240010738	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
325240010739	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
325240010740	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240010741	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240010742	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
325240010743	putative effector binding pocket; other site
325240010744	dimerization interface [polypeptide binding]; other site
325240010745	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
325240010746	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
325240010747	Nucleoside recognition; Region: Gate; pfam07670
325240010748	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
325240010749	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
325240010750	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
325240010751	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
325240010752	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
325240010753	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
325240010754	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
325240010755	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
325240010756	Rhomboid family; Region: Rhomboid; pfam01694
325240010757	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
325240010758	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
325240010759	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
325240010760	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
325240010761	LrgB-like family; Region: LrgB; pfam04172
325240010762	LrgA family; Region: LrgA; cl00608
325240010763	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240010764	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240010765	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
325240010766	putative dimerization interface [polypeptide binding]; other site
325240010767	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
325240010768	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
325240010769	substrate binding pocket [chemical binding]; other site
325240010770	membrane-bound complex binding site; other site
325240010771	hinge residues; other site
325240010772	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
325240010773	dimer interface [polypeptide binding]; other site
325240010774	conserved gate region; other site
325240010775	putative PBP binding loops; other site
325240010776	ABC-ATPase subunit interface; other site
325240010777	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
325240010778	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
325240010779	Walker A/P-loop; other site
325240010780	ATP binding site [chemical binding]; other site
325240010781	Q-loop/lid; other site
325240010782	ABC transporter signature motif; other site
325240010783	Walker B; other site
325240010784	D-loop; other site
325240010785	H-loop/switch region; other site
325240010786	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
325240010787	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
325240010788	FMN binding site [chemical binding]; other site
325240010789	dimer interface [polypeptide binding]; other site
325240010790	DNA-J related protein; Region: DNAJ_related; pfam12339
325240010791	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
325240010792	HSP70 interaction site [polypeptide binding]; other site
325240010793	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
325240010794	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
325240010795	catalytic residues [active]
325240010796	hinge region; other site
325240010797	alpha helical domain; other site
325240010798	GlyGly-CTERM domain; Region: GlyGly_CTERM; TIGR03501
325240010799	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
325240010800	Flavodoxin domain; Region: Flavodoxin_5; cl17428
325240010801	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240010802	Major Facilitator Superfamily; Region: MFS_1; pfam07690
325240010803	putative substrate translocation pore; other site
325240010804	TIGR03899 family protein; Region: TIGR03899
325240010805	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
325240010806	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
325240010807	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240010808	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240010809	metal binding site [ion binding]; metal-binding site
325240010810	active site
325240010811	I-site; other site
325240010812	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240010813	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
325240010814	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240010815	ATP binding site [chemical binding]; other site
325240010816	Mg2+ binding site [ion binding]; other site
325240010817	G-X-G motif; other site
325240010818	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
325240010819	ligand-binding site [chemical binding]; other site
325240010820	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
325240010821	TrkA-C domain; Region: TrkA_C; pfam02080
325240010822	TrkA-C domain; Region: TrkA_C; pfam02080
325240010823	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
325240010824	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
325240010825	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
325240010826	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
325240010827	CysD dimerization site [polypeptide binding]; other site
325240010828	G1 box; other site
325240010829	putative GEF interaction site [polypeptide binding]; other site
325240010830	GTP/Mg2+ binding site [chemical binding]; other site
325240010831	Switch I region; other site
325240010832	G2 box; other site
325240010833	G3 box; other site
325240010834	Switch II region; other site
325240010835	G4 box; other site
325240010836	G5 box; other site
325240010837	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
325240010838	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
325240010839	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
325240010840	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
325240010841	Active Sites [active]
325240010842	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
325240010843	active site
325240010844	SAM binding site [chemical binding]; other site
325240010845	homodimer interface [polypeptide binding]; other site
325240010846	Phage endonuclease I; Region: Phage_endo_I; cl11622
325240010847	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
325240010848	dimerization interface [polypeptide binding]; other site
325240010849	substrate binding site [chemical binding]; other site
325240010850	active site
325240010851	calcium binding site [ion binding]; other site
325240010852	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
325240010853	Active site serine [active]
325240010854	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
325240010855	Transglycosylase; Region: Transgly; cl17702
325240010856	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
325240010857	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
325240010858	Active Sites [active]
325240010859	sulfite reductase subunit beta; Provisional; Region: PRK13504
325240010860	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
325240010861	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
325240010862	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
325240010863	Flavodoxin; Region: Flavodoxin_1; pfam00258
325240010864	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
325240010865	FAD binding pocket [chemical binding]; other site
325240010866	FAD binding motif [chemical binding]; other site
325240010867	catalytic residues [active]
325240010868	NAD binding pocket [chemical binding]; other site
325240010869	phosphate binding motif [ion binding]; other site
325240010870	beta-alpha-beta structure motif; other site
325240010871	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
325240010872	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
325240010873	ligand binding site [chemical binding]; other site
325240010874	homodimer interface [polypeptide binding]; other site
325240010875	NAD(P) binding site [chemical binding]; other site
325240010876	trimer interface B [polypeptide binding]; other site
325240010877	trimer interface A [polypeptide binding]; other site
325240010878	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
325240010879	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
325240010880	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
325240010881	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
325240010882	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
325240010883	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
325240010884	putative ribose interaction site [chemical binding]; other site
325240010885	putative ADP binding site [chemical binding]; other site
325240010886	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
325240010887	active site
325240010888	HIGH motif; other site
325240010889	nucleotide binding site [chemical binding]; other site
325240010890	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
325240010891	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
325240010892	putative acyl-acceptor binding pocket; other site
325240010893	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
325240010894	potassium/proton antiporter; Reviewed; Region: PRK05326
325240010895	TrkA-C domain; Region: TrkA_C; pfam02080
325240010896	Transporter associated domain; Region: CorC_HlyC; smart01091
325240010897	L,D-transpeptidase; Provisional; Region: PRK10260
325240010898	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
325240010899	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
325240010900	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231
325240010901	putative active site [active]
325240010902	Zn binding site [ion binding]; other site
325240010903	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
325240010904	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
325240010905	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
325240010906	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
325240010907	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
325240010908	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240010909	active site
325240010910	phosphorylation site [posttranslational modification]
325240010911	intermolecular recognition site; other site
325240010912	dimerization interface [polypeptide binding]; other site
325240010913	Transcriptional regulator; Region: CitT; pfam12431
325240010914	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
325240010915	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
325240010916	PAS domain; Region: PAS; smart00091
325240010917	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240010918	ATP binding site [chemical binding]; other site
325240010919	Mg2+ binding site [ion binding]; other site
325240010920	G-X-G motif; other site
325240010921	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
325240010922	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
325240010923	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
325240010924	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
325240010925	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
325240010926	Predicted ATPase [General function prediction only]; Region: COG1485
325240010927	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240010928	Walker A/P-loop; other site
325240010929	ATP binding site [chemical binding]; other site
325240010930	ABC transporter signature motif; other site
325240010931	Walker B; other site
325240010932	D-loop; other site
325240010933	H-loop/switch region; other site
325240010934	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240010935	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240010936	Integrase core domain; Region: rve; pfam00665
325240010937	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
325240010938	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
325240010939	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240010940	dimerization interface [polypeptide binding]; other site
325240010941	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240010942	dimer interface [polypeptide binding]; other site
325240010943	putative CheW interface [polypeptide binding]; other site
325240010944	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240010945	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240010946	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
325240010947	dimerization interface [polypeptide binding]; other site
325240010948	Domain of unknown function (DUF897); Region: DUF897; pfam05982
325240010949	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
325240010950	GAF domain; Region: GAF; pfam01590
325240010951	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240010952	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240010953	metal binding site [ion binding]; metal-binding site
325240010954	active site
325240010955	I-site; other site
325240010956	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
325240010957	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
325240010958	metal binding triad; other site
325240010959	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
325240010960	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
325240010961	metal binding triad; other site
325240010962	spermidine synthase; Provisional; Region: PRK03612
325240010963	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
325240010964	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938
325240010965	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
325240010966	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
325240010967	Ion channel; Region: Ion_trans_2; pfam07885
325240010968	Uncharacterized conserved protein [Function unknown]; Region: COG3025
325240010969	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
325240010970	putative active site [active]
325240010971	putative metal binding residues [ion binding]; other site
325240010972	signature motif; other site
325240010973	putative triphosphate binding site [ion binding]; other site
325240010974	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
325240010975	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
325240010976	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
325240010977	Bacterial SH3 domain homologues; Region: SH3b; smart00287
325240010978	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
325240010979	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
325240010980	Proline dehydrogenase; Region: Pro_dh; pfam01619
325240010981	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
325240010982	Glutamate binding site [chemical binding]; other site
325240010983	NAD binding site [chemical binding]; other site
325240010984	catalytic residues [active]
325240010985	Protein of unknown function, DUF599; Region: DUF599; pfam04654
325240010986	Helix-turn-helix domain; Region: HTH_17; pfam12728
325240010987	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
325240010988	putative active site [active]
325240010989	putative metal binding residues [ion binding]; other site
325240010990	signature motif; other site
325240010991	putative triphosphate binding site [ion binding]; other site
325240010992	dimer interface [polypeptide binding]; other site
325240010993	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
325240010994	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
325240010995	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240010996	Walker A/P-loop; other site
325240010997	ATP binding site [chemical binding]; other site
325240010998	Q-loop/lid; other site
325240010999	ABC transporter signature motif; other site
325240011000	Walker B; other site
325240011001	D-loop; other site
325240011002	H-loop/switch region; other site
325240011003	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
325240011004	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
325240011005	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240011006	Walker A/P-loop; other site
325240011007	ATP binding site [chemical binding]; other site
325240011008	Q-loop/lid; other site
325240011009	ABC transporter signature motif; other site
325240011010	Walker B; other site
325240011011	D-loop; other site
325240011012	H-loop/switch region; other site
325240011013	Protein of unknown function (DUF3626); Region: DUF3626; pfam12294
325240011014	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
325240011015	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
325240011016	ATP binding site [chemical binding]; other site
325240011017	Mg++ binding site [ion binding]; other site
325240011018	motif III; other site
325240011019	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240011020	nucleotide binding region [chemical binding]; other site
325240011021	ATP-binding site [chemical binding]; other site
325240011022	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
325240011023	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
325240011024	ATP binding site [chemical binding]; other site
325240011025	Mg++ binding site [ion binding]; other site
325240011026	motif III; other site
325240011027	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240011028	nucleotide binding region [chemical binding]; other site
325240011029	ATP-binding site [chemical binding]; other site
325240011030	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
325240011031	putative RNA binding site [nucleotide binding]; other site
325240011032	Pirin-related protein [General function prediction only]; Region: COG1741
325240011033	Pirin; Region: Pirin; pfam02678
325240011034	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
325240011035	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
325240011036	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
325240011037	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
325240011038	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
325240011039	DNA binding site [nucleotide binding]
325240011040	active site
325240011041	short chain dehydrogenase; Provisional; Region: PRK07478
325240011042	classical (c) SDRs; Region: SDR_c; cd05233
325240011043	NAD(P) binding site [chemical binding]; other site
325240011044	active site
325240011045	SnoaL-like domain; Region: SnoaL_2; pfam12680
325240011046	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
325240011047	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
325240011048	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
325240011049	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240011050	Walker A/P-loop; other site
325240011051	ATP binding site [chemical binding]; other site
325240011052	Q-loop/lid; other site
325240011053	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
325240011054	ABC transporter; Region: ABC_tran_2; pfam12848
325240011055	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
325240011056	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
325240011057	Uncharacterized conserved protein [Function unknown]; Region: COG3791
325240011058	Predicted transcriptional regulators [Transcription]; Region: COG1733
325240011059	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
325240011060	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
325240011061	classical (c) SDRs; Region: SDR_c; cd05233
325240011062	NAD(P) binding site [chemical binding]; other site
325240011063	active site
325240011064	Transcriptional activator [Transcription]; Region: ChrR; COG3806
325240011065	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
325240011066	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
325240011067	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
325240011068	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
325240011069	putative hydrolase; Provisional; Region: PRK10985
325240011070	Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180
325240011071	phosphoribulokinase; Provisional; Region: PRK15453
325240011072	active site
325240011073	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
325240011074	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240011075	Coenzyme A binding pocket [chemical binding]; other site
325240011076	aminopeptidase B; Provisional; Region: PRK05015
325240011077	Peptidase; Region: DUF3663; pfam12404
325240011078	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
325240011079	interface (dimer of trimers) [polypeptide binding]; other site
325240011080	Substrate-binding/catalytic site; other site
325240011081	Zn-binding sites [ion binding]; other site
325240011082	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
325240011083	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
325240011084	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
325240011085	active site
325240011086	nucleotide binding site [chemical binding]; other site
325240011087	HIGH motif; other site
325240011088	KMSKS motif; other site
325240011089	poly(A) polymerase; Region: pcnB; TIGR01942
325240011090	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
325240011091	active site
325240011092	NTP binding site [chemical binding]; other site
325240011093	metal binding triad [ion binding]; metal-binding site
325240011094	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
325240011095	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
325240011096	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
325240011097	catalytic center binding site [active]
325240011098	ATP binding site [chemical binding]; other site
325240011099	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
325240011100	oligomerization interface [polypeptide binding]; other site
325240011101	active site
325240011102	metal binding site [ion binding]; metal-binding site
325240011103	Pantoate-beta-alanine ligase; Region: PanC; cd00560
325240011104	pantoate--beta-alanine ligase; Region: panC; TIGR00018
325240011105	active site
325240011106	ATP-binding site [chemical binding]; other site
325240011107	pantoate-binding site; other site
325240011108	HXXH motif; other site
325240011109	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
325240011110	Curlin associated repeat; Region: Curlin_rpt; pfam07012
325240011111	Curlin associated repeat; Region: Curlin_rpt; pfam07012
325240011112	major curlin subunit; Provisional; Region: csgA; PRK10051
325240011113	Curlin associated repeat; Region: Curlin_rpt; pfam07012
325240011114	Curlin associated repeat; Region: Curlin_rpt; pfam07012
325240011115	Curlin associated repeat; Region: Curlin_rpt; pfam07012
325240011116	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
325240011117	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
325240011118	DNA binding residues [nucleotide binding]
325240011119	dimerization interface [polypeptide binding]; other site
325240011120	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
325240011121	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
325240011122	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
325240011123	ligand binding site [chemical binding]; other site
325240011124	NAD binding site [chemical binding]; other site
325240011125	tetramer interface [polypeptide binding]; other site
325240011126	catalytic site [active]
325240011127	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
325240011128	L-serine binding site [chemical binding]; other site
325240011129	ACT domain interface; other site
325240011130	putative global regulator; Reviewed; Region: PRK09559
325240011131	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
325240011132	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
325240011133	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240011134	active site
325240011135	phosphorylation site [posttranslational modification]
325240011136	intermolecular recognition site; other site
325240011137	dimerization interface [polypeptide binding]; other site
325240011138	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
325240011139	Zn2+ binding site [ion binding]; other site
325240011140	Mg2+ binding site [ion binding]; other site
325240011141	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
325240011142	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
325240011143	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240011144	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
325240011145	putative active site [active]
325240011146	heme pocket [chemical binding]; other site
325240011147	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
325240011148	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240011149	putative active site [active]
325240011150	heme pocket [chemical binding]; other site
325240011151	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
325240011152	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240011153	putative active site [active]
325240011154	heme pocket [chemical binding]; other site
325240011155	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240011156	putative active site [active]
325240011157	heme pocket [chemical binding]; other site
325240011158	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240011159	dimer interface [polypeptide binding]; other site
325240011160	phosphorylation site [posttranslational modification]
325240011161	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240011162	ATP binding site [chemical binding]; other site
325240011163	Mg2+ binding site [ion binding]; other site
325240011164	G-X-G motif; other site
325240011165	Response regulator receiver domain; Region: Response_reg; pfam00072
325240011166	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240011167	active site
325240011168	phosphorylation site [posttranslational modification]
325240011169	intermolecular recognition site; other site
325240011170	dimerization interface [polypeptide binding]; other site
325240011171	Response regulator receiver domain; Region: Response_reg; pfam00072
325240011172	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240011173	active site
325240011174	phosphorylation site [posttranslational modification]
325240011175	intermolecular recognition site; other site
325240011176	dimerization interface [polypeptide binding]; other site
325240011177	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
325240011178	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
325240011179	amino acid carrier protein; Region: agcS; TIGR00835
325240011180	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
325240011181	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
325240011182	Walker A/P-loop; other site
325240011183	ATP binding site [chemical binding]; other site
325240011184	Q-loop/lid; other site
325240011185	ABC transporter signature motif; other site
325240011186	Walker B; other site
325240011187	D-loop; other site
325240011188	H-loop/switch region; other site
325240011189	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
325240011190	FtsX-like permease family; Region: FtsX; pfam02687
325240011191	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
325240011192	NapD protein; Region: NapD; pfam03927
325240011193	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
325240011194	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
325240011195	[4Fe-4S] binding site [ion binding]; other site
325240011196	molybdopterin cofactor binding site; other site
325240011197	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
325240011198	molybdopterin cofactor binding site; other site
325240011199	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
325240011200	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240011201	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240011202	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
325240011203	putative dimerization interface [polypeptide binding]; other site
325240011204	elongation factor G; Reviewed; Region: PRK00007
325240011205	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
325240011206	G1 box; other site
325240011207	putative GEF interaction site [polypeptide binding]; other site
325240011208	GTP/Mg2+ binding site [chemical binding]; other site
325240011209	Switch I region; other site
325240011210	G2 box; other site
325240011211	G3 box; other site
325240011212	Switch II region; other site
325240011213	G4 box; other site
325240011214	G5 box; other site
325240011215	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
325240011216	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
325240011217	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
325240011218	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240011219	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240011220	metal binding site [ion binding]; metal-binding site
325240011221	active site
325240011222	I-site; other site
325240011223	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240011224	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240011225	Walker A motif; other site
325240011226	ATP binding site [chemical binding]; other site
325240011227	Walker B motif; other site
325240011228	Integrase core domain; Region: rve; pfam00665
325240011229	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
325240011230	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
325240011231	substrate binding pocket [chemical binding]; other site
325240011232	membrane-bound complex binding site; other site
325240011233	hinge residues; other site
325240011234	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
325240011235	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
325240011236	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
325240011237	ATP-grasp domain; Region: ATP-grasp_4; cl17255
325240011238	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
325240011239	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
325240011240	carboxyltransferase (CT) interaction site; other site
325240011241	biotinylation site [posttranslational modification]; other site
325240011242	LysR family transcriptional regulator; Provisional; Region: PRK14997
325240011243	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240011244	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
325240011245	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
325240011246	putative effector binding pocket; other site
325240011247	dimerization interface [polypeptide binding]; other site
325240011248	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
325240011249	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
325240011250	putative substrate binding pocket [chemical binding]; other site
325240011251	AC domain interface; other site
325240011252	catalytic triad [active]
325240011253	AB domain interface; other site
325240011254	hypothetical protein; Provisional; Region: PRK04860
325240011255	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
325240011256	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
325240011257	RNA methyltransferase, RsmE family; Region: TIGR00046
325240011258	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
325240011259	glutathione synthetase; Provisional; Region: PRK05246
325240011260	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
325240011261	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
325240011262	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
325240011263	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240011264	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
325240011265	dimer interface [polypeptide binding]; other site
325240011266	Alkaline phosphatase homologues; Region: alkPPc; smart00098
325240011267	active site
325240011268	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
325240011269	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
325240011270	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
325240011271	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240011272	S-adenosylmethionine binding site [chemical binding]; other site
325240011273	Protein of unknown function (DUF342); Region: DUF342; pfam03961
325240011274	protein structure with unknown function; Region: DUF4144; pfam13642
325240011275	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
325240011276	Peptidase family M50; Region: Peptidase_M50; pfam02163
325240011277	active site
325240011278	putative substrate binding region [chemical binding]; other site
325240011279	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
325240011280	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
325240011281	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
325240011282	Walker A/P-loop; other site
325240011283	ATP binding site [chemical binding]; other site
325240011284	Q-loop/lid; other site
325240011285	ABC transporter signature motif; other site
325240011286	Walker B; other site
325240011287	D-loop; other site
325240011288	H-loop/switch region; other site
325240011289	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
325240011290	FtsX-like permease family; Region: FtsX; pfam02687
325240011291	macrolide transporter subunit MacA; Provisional; Region: PRK11578
325240011292	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
325240011293	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240011294	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
325240011295	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
325240011296	TOBE domain; Region: TOBE; cl01440
325240011297	TOBE domain; Region: TOBE; cl01440
325240011298	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
325240011299	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
325240011300	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
325240011301	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
325240011302	dimer interface [polypeptide binding]; other site
325240011303	conserved gate region; other site
325240011304	putative PBP binding loops; other site
325240011305	ABC-ATPase subunit interface; other site
325240011306	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
325240011307	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240011308	Walker A/P-loop; other site
325240011309	ATP binding site [chemical binding]; other site
325240011310	Q-loop/lid; other site
325240011311	ABC transporter signature motif; other site
325240011312	Walker B; other site
325240011313	D-loop; other site
325240011314	H-loop/switch region; other site
325240011315	TOBE domain; Region: TOBE; cl01440
325240011316	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
325240011317	active site
325240011318	catalytic residues [active]
325240011319	DNA binding site [nucleotide binding]
325240011320	Int/Topo IB signature motif; other site
325240011321	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
325240011322	non-specific DNA binding site [nucleotide binding]; other site
325240011323	salt bridge; other site
325240011324	sequence-specific DNA binding site [nucleotide binding]; other site
325240011325	Transposase; Region: HTH_Tnp_1; cl17663
325240011326	putative transposase OrfB; Reviewed; Region: PHA02517
325240011327	Homeodomain-like domain; Region: HTH_32; pfam13565
325240011328	Integrase core domain; Region: rve; pfam00665
325240011329	Integrase core domain; Region: rve_3; pfam13683
325240011330	Transposase; Region: HTH_Tnp_1; pfam01527
325240011331	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240011332	Integrase core domain; Region: rve; pfam00665
325240011333	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240011334	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240011335	Walker A motif; other site
325240011336	ATP binding site [chemical binding]; other site
325240011337	Walker B motif; other site
325240011338	putative transposase OrfB; Reviewed; Region: PHA02517
325240011339	HTH-like domain; Region: HTH_21; pfam13276
325240011340	Integrase core domain; Region: rve; pfam00665
325240011341	Integrase core domain; Region: rve_2; pfam13333
325240011342	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
325240011343	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
325240011344	active site
325240011345	DNA binding site [nucleotide binding]
325240011346	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
325240011347	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
325240011348	Catalytic site [active]
325240011349	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240011350	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240011351	Integrase core domain; Region: rve; pfam00665
325240011352	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
325240011353	active site
325240011354	catalytic residues [active]
325240011355	DNA binding site [nucleotide binding]
325240011356	Int/Topo IB signature motif; other site
325240011357	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240011358	Walker A motif; other site
325240011359	ATP binding site [chemical binding]; other site
325240011360	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240011361	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
325240011362	Walker A motif; other site
325240011363	ATP binding site [chemical binding]; other site
325240011364	Walker B motif; other site
325240011365	arginine finger; other site
325240011366	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
325240011367	MPN+ (JAMM) motif; other site
325240011368	Zinc-binding site [ion binding]; other site
325240011369	Protein of unknown function (DUF2787); Region: DUF2787; pfam10980
325240011370	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
325240011371	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
325240011372	HAMP domain; Region: HAMP; pfam00672
325240011373	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
325240011374	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240011375	dimer interface [polypeptide binding]; other site
325240011376	putative CheW interface [polypeptide binding]; other site
325240011377	Hemerythrin; Region: Hemerythrin; cd12107
325240011378	Fe binding site [ion binding]; other site
325240011379	Protein of unknown function (DUF3149); Region: DUF3149; pfam11346
325240011380	Superinfection exclusion protein B; Region: SieB; pfam14163
325240011381	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
325240011382	dimer interface [polypeptide binding]; other site
325240011383	phosphorylation site [posttranslational modification]
325240011384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240011385	ATP binding site [chemical binding]; other site
325240011386	Mg2+ binding site [ion binding]; other site
325240011387	G-X-G motif; other site
325240011388	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
325240011389	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
325240011390	putative ATP binding site [chemical binding]; other site
325240011391	putative substrate interface [chemical binding]; other site
325240011392	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
325240011393	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
325240011394	eyelet of channel; other site
325240011395	trimer interface [polypeptide binding]; other site
325240011396	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
325240011397	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
325240011398	eyelet of channel; other site
325240011399	trimer interface [polypeptide binding]; other site
325240011400	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
325240011401	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
325240011402	CAP-like domain; other site
325240011403	active site
325240011404	primary dimer interface [polypeptide binding]; other site
325240011405	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
325240011406	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
325240011407	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
325240011408	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240011409	ATP binding site [chemical binding]; other site
325240011410	Mg2+ binding site [ion binding]; other site
325240011411	G-X-G motif; other site
325240011412	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
325240011413	anchoring element; other site
325240011414	dimer interface [polypeptide binding]; other site
325240011415	ATP binding site [chemical binding]; other site
325240011416	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
325240011417	active site
325240011418	metal binding site [ion binding]; metal-binding site
325240011419	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
325240011420	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
325240011421	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
325240011422	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
325240011423	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
325240011424	active site
325240011425	metal binding site [ion binding]; metal-binding site
325240011426	hexamer interface [polypeptide binding]; other site
325240011427	Protein of unknown function (DUF1249); Region: DUF1249; pfam06853
325240011428	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
325240011429	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
325240011430	dimer interface [polypeptide binding]; other site
325240011431	ADP-ribose binding site [chemical binding]; other site
325240011432	active site
325240011433	nudix motif; other site
325240011434	metal binding site [ion binding]; metal-binding site
325240011435	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
325240011436	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
325240011437	Protein of unknown function (DUF461); Region: DUF461; pfam04314
325240011438	enoyl-CoA hydratase; Provisional; Region: PRK06688
325240011439	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
325240011440	substrate binding site [chemical binding]; other site
325240011441	oxyanion hole (OAH) forming residues; other site
325240011442	trimer interface [polypeptide binding]; other site
325240011443	PspC domain; Region: PspC; pfam04024
325240011444	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
325240011445	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
325240011446	FMN binding site [chemical binding]; other site
325240011447	active site
325240011448	catalytic residues [active]
325240011449	substrate binding site [chemical binding]; other site
325240011450	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
325240011451	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
325240011452	active site
325240011453	DNA binding site [nucleotide binding]
325240011454	Int/Topo IB signature motif; other site
325240011455	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
325240011456	Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956
325240011457	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
325240011458	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
325240011459	oligomer interface [polypeptide binding]; other site
325240011460	active site residues [active]
325240011461	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
325240011462	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
325240011463	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
325240011464	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
325240011465	Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720
325240011466	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
325240011467	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
325240011468	catalytic site [active]
325240011469	putative active site [active]
325240011470	putative substrate binding site [chemical binding]; other site
325240011471	dimer interface [polypeptide binding]; other site
325240011472	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
325240011473	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
325240011474	non-specific DNA binding site [nucleotide binding]; other site
325240011475	salt bridge; other site
325240011476	sequence-specific DNA binding site [nucleotide binding]; other site
325240011477	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
325240011478	active site
325240011479	DNA binding site [nucleotide binding]
325240011480	Int/Topo IB signature motif; other site
325240011481	Replication protein P; Region: Phage_lambda_P; pfam06992
325240011482	Helix-turn-helix domain; Region: HTH_36; pfam13730
325240011483	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
325240011484	DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744
325240011485	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
325240011486	non-specific DNA binding site [nucleotide binding]; other site
325240011487	salt bridge; other site
325240011488	Predicted transcriptional regulator [Transcription]; Region: COG2932
325240011489	sequence-specific DNA binding site [nucleotide binding]; other site
325240011490	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
325240011491	Catalytic site [active]
325240011492	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
325240011493	DNA methylase; Region: N6_N4_Mtase; pfam01555
325240011494	Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112
325240011495	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
325240011496	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240011497	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240011498	Integrase core domain; Region: rve; pfam00665
325240011499	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
325240011500	Coenzyme A binding pocket [chemical binding]; other site
325240011501	Protein of unknown function (DUF1778); Region: DUF1778; cl01845
325240011502	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
325240011503	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
325240011504	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
325240011505	N-terminal plug; other site
325240011506	ligand-binding site [chemical binding]; other site
325240011507	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
325240011508	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
325240011509	alanine racemase; Reviewed; Region: alr; PRK00053
325240011510	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
325240011511	active site
325240011512	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
325240011513	substrate binding site [chemical binding]; other site
325240011514	catalytic residues [active]
325240011515	dimer interface [polypeptide binding]; other site
325240011516	replicative DNA helicase; Provisional; Region: PRK08006
325240011517	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
325240011518	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
325240011519	Walker A motif; other site
325240011520	ATP binding site [chemical binding]; other site
325240011521	Walker B motif; other site
325240011522	DNA binding loops [nucleotide binding]
325240011523	Peptidase S46; Region: Peptidase_S46; pfam10459
325240011524	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
325240011525	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
325240011526	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
325240011527	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
325240011528	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
325240011529	primosomal replication protein N; Provisional; Region: PRK02801
325240011530	generic binding surface II; other site
325240011531	generic binding surface I; other site
325240011532	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
325240011533	Protein of unknown function, DUF481; Region: DUF481; pfam04338
325240011534	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240011535	Major Facilitator Superfamily; Region: MFS_1; pfam07690
325240011536	putative substrate translocation pore; other site
325240011537	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
325240011538	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
325240011539	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
325240011540	exoribonuclease R; Provisional; Region: PRK11642
325240011541	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
325240011542	RNB domain; Region: RNB; pfam00773
325240011543	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
325240011544	RNA binding site [nucleotide binding]; other site
325240011545	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
325240011546	Sel1-like repeats; Region: SEL1; smart00671
325240011547	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
325240011548	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
325240011549	GDP-binding site [chemical binding]; other site
325240011550	ACT binding site; other site
325240011551	IMP binding site; other site
325240011552	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
325240011553	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
325240011554	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
325240011555	23S rRNA interface [nucleotide binding]; other site
325240011556	L3 interface [polypeptide binding]; other site
325240011557	Predicted ATPase [General function prediction only]; Region: COG1485
325240011558	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
325240011559	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
325240011560	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
325240011561	protein binding site [polypeptide binding]; other site
325240011562	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
325240011563	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
325240011564	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
325240011565	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
325240011566	protein binding site [polypeptide binding]; other site
325240011567	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
325240011568	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
325240011569	hinge; other site
325240011570	active site
325240011571	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
325240011572	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
325240011573	anti sigma factor interaction site; other site
325240011574	regulatory phosphorylation site [posttranslational modification]; other site
325240011575	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
325240011576	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
325240011577	mce related protein; Region: MCE; pfam02470
325240011578	conserved hypothetical integral membrane protein; Region: TIGR00056
325240011579	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
325240011580	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
325240011581	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
325240011582	Walker A/P-loop; other site
325240011583	ATP binding site [chemical binding]; other site
325240011584	Q-loop/lid; other site
325240011585	ABC transporter signature motif; other site
325240011586	Walker B; other site
325240011587	D-loop; other site
325240011588	H-loop/switch region; other site
325240011589	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
325240011590	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
325240011591	putative active site [active]
325240011592	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
325240011593	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
325240011594	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
325240011595	active site
325240011596	motif I; other site
325240011597	motif II; other site
325240011598	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
325240011599	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
325240011600	OstA-like protein; Region: OstA; cl00844
325240011601	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
325240011602	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
325240011603	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
325240011604	Walker A/P-loop; other site
325240011605	ATP binding site [chemical binding]; other site
325240011606	Q-loop/lid; other site
325240011607	ABC transporter signature motif; other site
325240011608	Walker B; other site
325240011609	D-loop; other site
325240011610	H-loop/switch region; other site
325240011611	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
325240011612	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
325240011613	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
325240011614	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
325240011615	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
325240011616	30S subunit binding site; other site
325240011617	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
325240011618	active site
325240011619	phosphorylation site [posttranslational modification]
325240011620	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
325240011621	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
325240011622	dimerization domain swap beta strand [polypeptide binding]; other site
325240011623	regulatory protein interface [polypeptide binding]; other site
325240011624	active site
325240011625	regulatory phosphorylation site [posttranslational modification]; other site
325240011626	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
325240011627	MgtE intracellular N domain; Region: MgtE_N; smart00924
325240011628	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
325240011629	Divalent cation transporter; Region: MgtE; pfam01769
325240011630	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
325240011631	molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537
325240011632	putative outer membrane lipoprotein; Provisional; Region: PRK10510
325240011633	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
325240011634	ligand binding site [chemical binding]; other site
325240011635	Transposase; Region: HTH_Tnp_1; cl17663
325240011636	Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718
325240011637	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
325240011638	ATP binding site [chemical binding]; other site
325240011639	lipoprotein; Provisional; Region: PRK11443
325240011640	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
325240011641	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
325240011642	active site
325240011643	GAF domain; Region: GAF; pfam01590
325240011644	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240011645	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240011646	metal binding site [ion binding]; metal-binding site
325240011647	active site
325240011648	I-site; other site
325240011649	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240011650	Transposase; Region: HTH_Tnp_1; cl17663
325240011651	Winged helix-turn helix; Region: HTH_29; pfam13551
325240011652	Homeodomain-like domain; Region: HTH_32; pfam13565
325240011653	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
325240011654	Integrase core domain; Region: rve; pfam00665
325240011655	Integrase core domain; Region: rve_3; pfam13683
325240011656	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240011657	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240011658	Integrase core domain; Region: rve; pfam00665
325240011659	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240011660	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240011661	Integrase core domain; Region: rve; pfam00665
325240011662	LysE type translocator; Region: LysE; cl00565
325240011663	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
325240011664	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
325240011665	Helix-turn-helix domain; Region: HTH_18; pfam12833
325240011666	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
325240011667	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
325240011668	dimer interface [polypeptide binding]; other site
325240011669	Alkaline phosphatase homologues; Region: alkPPc; smart00098
325240011670	active site
325240011671	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
325240011672	dimer interface [polypeptide binding]; other site
325240011673	Alkaline phosphatase homologues; Region: alkPPc; smart00098
325240011674	active site
325240011675	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
325240011676	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
325240011677	putative active site [active]
325240011678	heme pocket [chemical binding]; other site
325240011679	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240011680	PAS domain; Region: PAS_9; pfam13426
325240011681	putative active site [active]
325240011682	heme pocket [chemical binding]; other site
325240011683	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240011684	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240011685	metal binding site [ion binding]; metal-binding site
325240011686	active site
325240011687	I-site; other site
325240011688	Predicted transcriptional regulators [Transcription]; Region: COG1695
325240011689	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
325240011690	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
325240011691	DNA-binding site [nucleotide binding]; DNA binding site
325240011692	RNA-binding motif; other site
325240011693	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
325240011694	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
325240011695	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
325240011696	DNA binding residues [nucleotide binding]
325240011697	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
325240011698	Zn binding site [ion binding]; other site
325240011699	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
325240011700	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240011701	ATP binding site [chemical binding]; other site
325240011702	Q-loop/lid; other site
325240011703	ABC transporter signature motif; other site
325240011704	Walker B; other site
325240011705	D-loop; other site
325240011706	H-loop/switch region; other site
325240011707	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240011708	Walker A/P-loop; other site
325240011709	ATP binding site [chemical binding]; other site
325240011710	Q-loop/lid; other site
325240011711	ABC transporter signature motif; other site
325240011712	Walker B; other site
325240011713	D-loop; other site
325240011714	H-loop/switch region; other site
325240011715	Protein of unknown function (DUF2999); Region: DUF2999; pfam11212
325240011716	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
325240011717	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240011718	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240011719	metal binding site [ion binding]; metal-binding site
325240011720	active site
325240011721	I-site; other site
325240011722	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
325240011723	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240011724	AAA domain; Region: AAA_23; pfam13476
325240011725	Walker A/P-loop; other site
325240011726	ATP binding site [chemical binding]; other site
325240011727	AAA domain; Region: AAA_21; pfam13304
325240011728	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240011729	ABC transporter signature motif; other site
325240011730	Walker B; other site
325240011731	D-loop; other site
325240011732	H-loop/switch region; other site
325240011733	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
325240011734	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
325240011735	ring oligomerisation interface [polypeptide binding]; other site
325240011736	ATP/Mg binding site [chemical binding]; other site
325240011737	stacking interactions; other site
325240011738	hinge regions; other site
325240011739	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
325240011740	oligomerisation interface [polypeptide binding]; other site
325240011741	mobile loop; other site
325240011742	roof hairpin; other site
325240011743	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
325240011744	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
325240011745	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240011746	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240011747	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
325240011748	putative effector binding pocket; other site
325240011749	dimerization interface [polypeptide binding]; other site
325240011750	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
325240011751	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240011752	Integrase core domain; Region: rve; pfam00665
325240011753	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240011754	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240011755	Walker A motif; other site
325240011756	ATP binding site [chemical binding]; other site
325240011757	Walker B motif; other site
325240011758	HsdM N-terminal domain; Region: HsdM_N; pfam12161
325240011759	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
325240011760	Methyltransferase domain; Region: Methyltransf_26; pfam13659
325240011761	AAA domain; Region: AAA_13; pfam13166
325240011762	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
325240011763	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
325240011764	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
325240011765	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
325240011766	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
325240011767	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
325240011768	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
325240011769	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
325240011770	ATP binding site [chemical binding]; other site
325240011771	putative Mg++ binding site [ion binding]; other site
325240011772	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
325240011773	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
325240011774	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
325240011775	active site
325240011776	catalytic residues [active]
325240011777	DNA binding site [nucleotide binding]
325240011778	Int/Topo IB signature motif; other site
325240011779	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
325240011780	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
325240011781	active site
325240011782	DNA binding site [nucleotide binding]
325240011783	Int/Topo IB signature motif; other site
325240011784	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
325240011785	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
325240011786	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
325240011787	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
325240011788	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
325240011789	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
325240011790	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
325240011791	DsbD alpha interface [polypeptide binding]; other site
325240011792	catalytic residues [active]
325240011793	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
325240011794	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
325240011795	TrkA-N domain; Region: TrkA_N; pfam02254
325240011796	galactokinase; Provisional; Region: PRK05101
325240011797	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
325240011798	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
325240011799	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
325240011800	active site
325240011801	catalytic residues [active]
325240011802	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
325240011803	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
325240011804	NAD(P) binding site [chemical binding]; other site
325240011805	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
325240011806	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
325240011807	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
325240011808	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
325240011809	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
325240011810	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
325240011811	Sel1-like repeats; Region: SEL1; smart00671
325240011812	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
325240011813	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
325240011814	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240011815	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
325240011816	Leucine rich repeat; Region: LRR_8; pfam13855
325240011817	Substrate binding site [chemical binding]; other site
325240011818	Leucine rich repeat; Region: LRR_8; pfam13855
325240011819	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
325240011820	active site
325240011821	ATP binding site [chemical binding]; other site
325240011822	substrate binding site [chemical binding]; other site
325240011823	activation loop (A-loop); other site
325240011824	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
325240011825	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
325240011826	N-acetyl-D-glucosamine binding site [chemical binding]; other site
325240011827	catalytic residue [active]
325240011828	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
325240011829	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
325240011830	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
325240011831	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
325240011832	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240011833	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240011834	Integrase core domain; Region: rve; pfam00665
325240011835	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
325240011836	Part of AAA domain; Region: AAA_19; pfam13245
325240011837	AAA domain; Region: AAA_12; pfam13087
325240011838	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
325240011839	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
325240011840	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
325240011841	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
325240011842	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
325240011843	Chorismate mutase type II; Region: CM_2; cl00693
325240011844	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
325240011845	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
325240011846	substrate binding pocket [chemical binding]; other site
325240011847	membrane-bound complex binding site; other site
325240011848	hinge residues; other site
325240011849	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
325240011850	active site
325240011851	homodimer interface [polypeptide binding]; other site
325240011852	homotetramer interface [polypeptide binding]; other site
325240011853	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240011854	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240011855	Integrase core domain; Region: rve; pfam00665
325240011856	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
325240011857	Aspartase; Region: Aspartase; cd01357
325240011858	active sites [active]
325240011859	tetramer interface [polypeptide binding]; other site
325240011860	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
325240011861	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
325240011862	fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13554
325240011863	Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581
325240011864	Iron-sulfur protein interface; other site
325240011865	proximal heme binding site [chemical binding]; other site
325240011866	distal heme binding site [chemical binding]; other site
325240011867	dimer interface [polypeptide binding]; other site
325240011868	fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626
325240011869	L-aspartate oxidase; Provisional; Region: PRK06175
325240011870	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
325240011871	fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552
325240011872	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
325240011873	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
325240011874	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
325240011875	eyelet of channel; other site
325240011876	trimer interface [polypeptide binding]; other site
325240011877	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
325240011878	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
325240011879	dimer interface [polypeptide binding]; other site
325240011880	ssDNA binding site [nucleotide binding]; other site
325240011881	tetramer (dimer of dimers) interface [polypeptide binding]; other site
325240011882	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240011883	Major Facilitator Superfamily; Region: MFS_1; pfam07690
325240011884	putative substrate translocation pore; other site
325240011885	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
325240011886	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
325240011887	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
325240011888	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
325240011889	M28 Zn-Peptidases; Region: M28_like_2; cd05662
325240011890	Peptidase family M28; Region: Peptidase_M28; pfam04389
325240011891	metal binding site [ion binding]; metal-binding site
325240011892	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
325240011893	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
325240011894	ATP binding site [chemical binding]; other site
325240011895	Mg++ binding site [ion binding]; other site
325240011896	motif III; other site
325240011897	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240011898	nucleotide binding region [chemical binding]; other site
325240011899	ATP-binding site [chemical binding]; other site
325240011900	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
325240011901	putative RNA binding site [nucleotide binding]; other site
325240011902	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
325240011903	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
325240011904	active site
325240011905	motif I; other site
325240011906	motif II; other site
325240011907	rarD protein; Region: rarD; TIGR00688
325240011908	EamA-like transporter family; Region: EamA; pfam00892
325240011909	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
325240011910	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
325240011911	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240011912	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240011913	Walker A motif; other site
325240011914	ATP binding site [chemical binding]; other site
325240011915	Walker B motif; other site
325240011916	Integrase core domain; Region: rve; pfam00665
325240011917	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
325240011918	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
325240011919	Cytochrome c; Region: Cytochrom_C; cl11414
325240011920	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
325240011921	Cytochrome c; Region: Cytochrom_C; pfam00034
325240011922	Protein of unknown function (DUF2955); Region: DUF2955; pfam11168
325240011923	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
325240011924	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
325240011925	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240011926	transcriptional regulator SlyA; Provisional; Region: PRK03573
325240011927	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
325240011928	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
325240011929	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240011930	dimerization interface [polypeptide binding]; other site
325240011931	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
325240011932	dimer interface [polypeptide binding]; other site
325240011933	putative CheW interface [polypeptide binding]; other site
325240011934	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
325240011935	FAD binding site [chemical binding]; other site
325240011936	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
325240011937	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
325240011938	nucleotide binding site [chemical binding]; other site
325240011939	substrate binding site [chemical binding]; other site
325240011940	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
325240011941	O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080
325240011942	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
325240011943	homodimer interface [polypeptide binding]; other site
325240011944	substrate-cofactor binding pocket; other site
325240011945	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240011946	catalytic residue [active]
325240011947	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
325240011948	dimerization interface [polypeptide binding]; other site
325240011949	DNA binding site [nucleotide binding]
325240011950	corepressor binding sites; other site
325240011951	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
325240011952	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
325240011953	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
325240011954	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
325240011955	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
325240011956	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
325240011957	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
325240011958	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
325240011959	putative hydrophobic ligand binding site [chemical binding]; other site
325240011960	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
325240011961	ATP binding site [chemical binding]; other site
325240011962	active site
325240011963	substrate binding site [chemical binding]; other site
325240011964	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
325240011965	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
325240011966	Zn2+ binding site [ion binding]; other site
325240011967	Mg2+ binding site [ion binding]; other site
325240011968	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
325240011969	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240011970	ATP binding site [chemical binding]; other site
325240011971	Mg2+ binding site [ion binding]; other site
325240011972	G-X-G motif; other site
325240011973	Integrase core domain; Region: rve; pfam00665
325240011974	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240011975	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240011976	Walker A motif; other site
325240011977	ATP binding site [chemical binding]; other site
325240011978	Walker B motif; other site
325240011979	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
325240011980	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
325240011981	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
325240011982	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
325240011983	ligand binding site [chemical binding]; other site
325240011984	flexible hinge region; other site
325240011985	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
325240011986	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
325240011987	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
325240011988	Methyltransferase domain; Region: Methyltransf_23; pfam13489
325240011989	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240011990	S-adenosylmethionine binding site [chemical binding]; other site
325240011991	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240011992	Uncharacterized conserved protein [Function unknown]; Region: COG2968
325240011993	oxidative stress defense protein; Provisional; Region: PRK11087
325240011994	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
325240011995	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
325240011996	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
325240011997	FeS/SAM binding site; other site
325240011998	fumarate hydratase; Reviewed; Region: fumC; PRK00485
325240011999	Class II fumarases; Region: Fumarase_classII; cd01362
325240012000	active site
325240012001	tetramer interface [polypeptide binding]; other site
325240012002	Domain of unknown function; Region: DUF331; pfam03889
325240012003	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
325240012004	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
325240012005	substrate binding pocket [chemical binding]; other site
325240012006	membrane-bound complex binding site; other site
325240012007	hinge residues; other site
325240012008	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
325240012009	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240012010	peptidase PmbA; Provisional; Region: PRK11040
325240012011	hypothetical protein; Provisional; Region: PRK05255
325240012012	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
325240012013	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240012014	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
325240012015	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
325240012016	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
325240012017	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
325240012018	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
325240012019	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
325240012020	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
325240012021	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
325240012022	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
325240012023	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
325240012024	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240012025	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
325240012026	protease TldD; Provisional; Region: tldD; PRK10735
325240012027	nitrilase; Region: PLN02798
325240012028	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
325240012029	putative active site [active]
325240012030	catalytic triad [active]
325240012031	dimer interface [polypeptide binding]; other site
325240012032	TIGR02099 family protein; Region: TIGR02099
325240012033	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
325240012034	ribonuclease G; Provisional; Region: PRK11712
325240012035	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
325240012036	homodimer interface [polypeptide binding]; other site
325240012037	oligonucleotide binding site [chemical binding]; other site
325240012038	Maf-like protein; Region: Maf; pfam02545
325240012039	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
325240012040	active site
325240012041	dimer interface [polypeptide binding]; other site
325240012042	rod shape-determining protein MreD; Region: MreD; cl01087
325240012043	rod shape-determining protein MreC; Region: mreC; TIGR00219
325240012044	rod shape-determining protein MreC; Region: MreC; pfam04085
325240012045	rod shape-determining protein MreB; Provisional; Region: PRK13927
325240012046	MreB and similar proteins; Region: MreB_like; cd10225
325240012047	nucleotide binding site [chemical binding]; other site
325240012048	Mg binding site [ion binding]; other site
325240012049	putative protofilament interaction site [polypeptide binding]; other site
325240012050	RodZ interaction site [polypeptide binding]; other site
325240012051	VcfQ bacterial pilus biogenesis protein, lectin domain; Region: lectin_VcfQ; cd06900
325240012052	putative metal binding site [ion binding]; other site
325240012053	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
325240012054	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
325240012055	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
325240012056	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
325240012057	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
325240012058	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
325240012059	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
325240012060	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
325240012061	Walker A motif; other site
325240012062	ATP binding site [chemical binding]; other site
325240012063	Walker B motif; other site
325240012064	Tetratricopeptide repeat; Region: TPR_16; pfam13432
325240012065	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240012066	TPR motif; other site
325240012067	binding surface
325240012068	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
325240012069	binding surface
325240012070	TPR motif; other site
325240012071	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
325240012072	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240012073	Walker A motif; other site
325240012074	ATP binding site [chemical binding]; other site
325240012075	Walker B motif; other site
325240012076	arginine finger; other site
325240012077	Secretin N-terminal domain; Region: Secretin_N_2; pfam07655
325240012078	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
325240012079	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
325240012080	regulatory protein CsrD; Provisional; Region: PRK11059
325240012081	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240012082	metal binding site [ion binding]; metal-binding site
325240012083	active site
325240012084	I-site; other site
325240012085	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240012086	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
325240012087	Malic enzyme, N-terminal domain; Region: malic; pfam00390
325240012088	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
325240012089	putative NAD(P) binding site [chemical binding]; other site
325240012090	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
325240012091	FimV N-terminal domain; Region: FimV_core; TIGR03505
325240012092	primosome assembly protein PriA; Validated; Region: PRK05580
325240012093	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
325240012094	ATP binding site [chemical binding]; other site
325240012095	putative Mg++ binding site [ion binding]; other site
325240012096	helicase superfamily c-terminal domain; Region: HELICc; smart00490
325240012097	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
325240012098	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
325240012099	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
325240012100	active site
325240012101	HIGH motif; other site
325240012102	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
325240012103	KMSK motif region; other site
325240012104	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
325240012105	tRNA binding surface [nucleotide binding]; other site
325240012106	anticodon binding site; other site
325240012107	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
325240012108	Sporulation related domain; Region: SPOR; pfam05036
325240012109	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
325240012110	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
325240012111	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
325240012112	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
325240012113	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
325240012114	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
325240012115	uridine phosphorylase; Provisional; Region: PRK11178
325240012116	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
325240012117	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841
325240012118	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
325240012119	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
325240012120	dimer interface [polypeptide binding]; other site
325240012121	active site
325240012122	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
325240012123	catalytic residues [active]
325240012124	substrate binding site [chemical binding]; other site
325240012125	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
325240012126	Mechanosensitive ion channel; Region: MS_channel; pfam00924
325240012127	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
325240012128	Sel1-like repeats; Region: SEL1; smart00671
325240012129	Sel1-like repeats; Region: SEL1; smart00671
325240012130	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
325240012131	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
325240012132	substrate binding pocket [chemical binding]; other site
325240012133	membrane-bound complex binding site; other site
325240012134	hinge residues; other site
325240012135	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
325240012136	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
325240012137	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
325240012138	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
325240012139	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240012140	ATP binding site [chemical binding]; other site
325240012141	Mg2+ binding site [ion binding]; other site
325240012142	G-X-G motif; other site
325240012143	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
325240012144	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240012145	active site
325240012146	phosphorylation site [posttranslational modification]
325240012147	intermolecular recognition site; other site
325240012148	dimerization interface [polypeptide binding]; other site
325240012149	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
325240012150	DNA binding residues [nucleotide binding]
325240012151	dimerization interface [polypeptide binding]; other site
325240012152	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
325240012153	RibD C-terminal domain; Region: RibD_C; cl17279
325240012154	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
325240012155	active site
325240012156	HslU subunit interaction site [polypeptide binding]; other site
325240012157	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
325240012158	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240012159	Walker A motif; other site
325240012160	ATP binding site [chemical binding]; other site
325240012161	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
325240012162	Walker B motif; other site
325240012163	arginine finger; other site
325240012164	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
325240012165	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
325240012166	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240012167	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240012168	Integrase core domain; Region: rve; pfam00665
325240012169	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
325240012170	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
325240012171	C factor cell-cell signaling protein; Provisional; Region: PRK09009
325240012172	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
325240012173	NADP binding site [chemical binding]; other site
325240012174	homodimer interface [polypeptide binding]; other site
325240012175	active site
325240012176	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
325240012177	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
325240012178	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
325240012179	active site
325240012180	Zn binding site [ion binding]; other site
325240012181	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
325240012182	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
325240012183	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
325240012184	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240012185	active site
325240012186	phosphorylation site [posttranslational modification]
325240012187	intermolecular recognition site; other site
325240012188	dimerization interface [polypeptide binding]; other site
325240012189	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
325240012190	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
325240012191	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240012192	ATP binding site [chemical binding]; other site
325240012193	Mg2+ binding site [ion binding]; other site
325240012194	G-X-G motif; other site
325240012195	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
325240012196	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
325240012197	NADP binding site [chemical binding]; other site
325240012198	active site
325240012199	putative substrate binding site [chemical binding]; other site
325240012200	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
325240012201	metal binding site [ion binding]; metal-binding site
325240012202	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
325240012203	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
325240012204	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
325240012205	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
325240012206	probable active site [active]
325240012207	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
325240012208	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
325240012209	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
325240012210	N-terminal plug; other site
325240012211	ligand-binding site [chemical binding]; other site
325240012212	Domain of unknown function (DUF386); Region: DUF386; cl01047
325240012213	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
325240012214	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
325240012215	DHHA2 domain; Region: DHHA2; pfam02833
325240012216	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
325240012217	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
325240012218	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
325240012219	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
325240012220	nucleophilic elbow; other site
325240012221	catalytic triad; other site
325240012222	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
325240012223	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
325240012224	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
325240012225	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
325240012226	active site
325240012227	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
325240012228	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
325240012229	putative active site [active]
325240012230	putative metal binding site [ion binding]; other site
325240012231	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
325240012232	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240012233	S-adenosylmethionine binding site [chemical binding]; other site
325240012234	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
325240012235	SCP-2 sterol transfer family; Region: SCP2; pfam02036
325240012236	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
325240012237	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
325240012238	twin arginine translocase protein A; Provisional; Region: tatA; PRK02958
325240012239	sec-independent translocase; Provisional; Region: PRK01770
325240012240	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
325240012241	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
325240012242	active site
325240012243	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
325240012244	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
325240012245	hypothetical protein; Region: PHA02277
325240012246	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240012247	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240012248	metal binding site [ion binding]; metal-binding site
325240012249	active site
325240012250	I-site; other site
325240012251	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
325240012252	dimer interface [polypeptide binding]; other site
325240012253	allosteric magnesium binding site [ion binding]; other site
325240012254	active site
325240012255	aspartate-rich active site metal binding site; other site
325240012256	Schiff base residues; other site
325240012257	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
325240012258	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
325240012259	substrate binding site [chemical binding]; other site
325240012260	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
325240012261	substrate binding site [chemical binding]; other site
325240012262	ligand binding site [chemical binding]; other site
325240012263	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
325240012264	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
325240012265	motif II; other site
325240012266	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
325240012267	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
325240012268	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
325240012269	active site
325240012270	Zn binding site [ion binding]; other site
325240012271	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
325240012272	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
325240012273	active site
325240012274	nucleophile elbow; other site
325240012275	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
325240012276	Surface antigen; Region: Bac_surface_Ag; pfam01103
325240012277	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
325240012278	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240012279	heme pocket [chemical binding]; other site
325240012280	putative active site [active]
325240012281	PAS fold; Region: PAS_3; pfam08447
325240012282	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240012283	PAS domain; Region: PAS_9; pfam13426
325240012284	putative active site [active]
325240012285	heme pocket [chemical binding]; other site
325240012286	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240012287	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240012288	metal binding site [ion binding]; metal-binding site
325240012289	active site
325240012290	I-site; other site
325240012291	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240012292	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
325240012293	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
325240012294	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
325240012295	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
325240012296	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
325240012297	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
325240012298	E3 interaction surface; other site
325240012299	lipoyl attachment site [posttranslational modification]; other site
325240012300	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
325240012301	E3 interaction surface; other site
325240012302	lipoyl attachment site [posttranslational modification]; other site
325240012303	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
325240012304	E3 interaction surface; other site
325240012305	lipoyl attachment site [posttranslational modification]; other site
325240012306	e3 binding domain; Region: E3_binding; pfam02817
325240012307	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
325240012308	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
325240012309	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
325240012310	dimer interface [polypeptide binding]; other site
325240012311	TPP-binding site [chemical binding]; other site
325240012312	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
325240012313	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
325240012314	DNA-binding site [nucleotide binding]; DNA binding site
325240012315	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
325240012316	regulatory protein AmpE; Provisional; Region: PRK10987
325240012317	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
325240012318	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
325240012319	amidase catalytic site [active]
325240012320	Zn binding residues [ion binding]; other site
325240012321	substrate binding site [chemical binding]; other site
325240012322	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
325240012323	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
325240012324	dimerization interface [polypeptide binding]; other site
325240012325	active site
325240012326	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
325240012327	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
325240012328	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
325240012329	Walker A motif; other site
325240012330	ATP binding site [chemical binding]; other site
325240012331	Walker B motif; other site
325240012332	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
325240012333	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
325240012334	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
325240012335	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
325240012336	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
325240012337	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
325240012338	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
325240012339	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
325240012340	CoA-binding site [chemical binding]; other site
325240012341	ATP-binding [chemical binding]; other site
325240012342	hypothetical protein; Provisional; Region: PRK05287
325240012343	Domain of unknown function (DUF329); Region: DUF329; pfam03884
325240012344	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
325240012345	active site
325240012346	8-oxo-dGMP binding site [chemical binding]; other site
325240012347	nudix motif; other site
325240012348	metal binding site [ion binding]; metal-binding site
325240012349	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
325240012350	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
325240012351	catalytic residues [active]
325240012352	exopolyphosphatase; Region: exo_poly_only; TIGR03706
325240012353	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
325240012354	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
325240012355	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
325240012356	ATP binding site [chemical binding]; other site
325240012357	Mg++ binding site [ion binding]; other site
325240012358	motif III; other site
325240012359	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240012360	nucleotide binding region [chemical binding]; other site
325240012361	ATP-binding site [chemical binding]; other site
325240012362	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
325240012363	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
325240012364	catalytic residues [active]
325240012365	transcription termination factor Rho; Provisional; Region: rho; PRK09376
325240012366	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
325240012367	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
325240012368	RNA binding site [nucleotide binding]; other site
325240012369	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
325240012370	multimer interface [polypeptide binding]; other site
325240012371	Walker A motif; other site
325240012372	ATP binding site [chemical binding]; other site
325240012373	Walker B motif; other site
325240012374	Transcriptional regulator [Transcription]; Region: LysR; COG0583
325240012375	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240012376	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
325240012377	putative effector binding pocket; other site
325240012378	dimerization interface [polypeptide binding]; other site
325240012379	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
325240012380	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
325240012381	putative NAD(P) binding site [chemical binding]; other site
325240012382	dimer interface [polypeptide binding]; other site
325240012383	Uncharacterized conserved protein [Function unknown]; Region: COG1359
325240012384	fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552
325240012385	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
325240012386	fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626
325240012387	L-aspartate oxidase; Provisional; Region: PRK06175
325240012388	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
325240012389	Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581
325240012390	Iron-sulfur protein interface; other site
325240012391	proximal heme binding site [chemical binding]; other site
325240012392	distal heme binding site [chemical binding]; other site
325240012393	dimer interface [polypeptide binding]; other site
325240012394	fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13554
325240012395	Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581
325240012396	Iron-sulfur protein interface; other site
325240012397	proximal heme binding site [chemical binding]; other site
325240012398	distal heme binding site [chemical binding]; other site
325240012399	dimer interface [polypeptide binding]; other site
325240012400	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
325240012401	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240012402	S-adenosylmethionine binding site [chemical binding]; other site
325240012403	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
325240012404	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
325240012405	FMN binding site [chemical binding]; other site
325240012406	active site
325240012407	catalytic residues [active]
325240012408	substrate binding site [chemical binding]; other site
325240012409	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
325240012410	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
325240012411	Part of AAA domain; Region: AAA_19; pfam13245
325240012412	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
325240012413	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
325240012414	Integrase core domain; Region: rve; pfam00665
325240012415	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240012416	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240012417	Walker A motif; other site
325240012418	ATP binding site [chemical binding]; other site
325240012419	Walker B motif; other site
325240012420	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
325240012421	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
325240012422	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
325240012423	ligand binding site [chemical binding]; other site
325240012424	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240012425	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240012426	Integrase core domain; Region: rve; pfam00665
325240012427	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
325240012428	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
325240012429	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
325240012430	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
325240012431	DNA binding residues [nucleotide binding]
325240012432	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
325240012433	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
325240012434	Flagellar protein FliS; Region: FliS; cl00654
325240012435	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
325240012436	flagellar capping protein; Reviewed; Region: fliD; PRK08032
325240012437	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
325240012438	flagellin; Provisional; Region: PRK12802
325240012439	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
325240012440	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
325240012441	flagellin; Provisional; Region: PRK12802
325240012442	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
325240012443	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
325240012444	flagellin; Provisional; Region: PRK12802
325240012445	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
325240012446	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
325240012447	flagellin; Provisional; Region: PRK12802
325240012448	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
325240012449	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
325240012450	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192
325240012451	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
325240012452	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191
325240012453	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
325240012454	peptidoglycan hydrolase; Reviewed; Region: flgJ; PRK12708
325240012455	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
325240012456	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
325240012457	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407
325240012458	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
325240012459	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
325240012460	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
325240012461	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
325240012462	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
325240012463	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
325240012464	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
325240012465	flagellar hook protein FlgE; Validated; Region: flgE; PRK06803
325240012466	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
325240012467	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
325240012468	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
325240012469	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
325240012470	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
325240012471	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802
325240012472	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
325240012473	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
325240012474	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685
325240012475	SAF-like; Region: SAF_2; pfam13144
325240012476	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
325240012477	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
325240012478	FlgN protein; Region: FlgN; pfam05130
325240012479	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
325240012480	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
325240012481	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
325240012482	Walker A motif; other site
325240012483	ATP binding site [chemical binding]; other site
325240012484	Walker B motif; other site
325240012485	flagellar assembly protein H; Provisional; Region: fliH; PRK13386
325240012486	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
325240012487	Flagellar assembly protein FliH; Region: FliH; pfam02108
325240012488	flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194
325240012489	FliG C-terminal domain; Region: FliG_C; pfam01706
325240012490	flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193
325240012491	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
325240012492	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
325240012493	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
325240012494	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
325240012495	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
325240012496	active site
325240012497	dimerization interface [polypeptide binding]; other site
325240012498	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240012499	Walker A motif; other site
325240012500	ATP binding site [chemical binding]; other site
325240012501	Walker B motif; other site
325240012502	arginine finger; other site
325240012503	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
325240012504	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
325240012505	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
325240012506	flagellar motor switch protein FliN; Region: fliN; TIGR02480
325240012507	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
325240012508	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
325240012509	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
325240012510	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
325240012511	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
325240012512	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
325240012513	FHIPEP family; Region: FHIPEP; pfam00771
325240012514	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
325240012515	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
325240012516	Hemerythrin-like domain; Region: Hr-like; cd12108
325240012517	Divergent AAA domain; Region: AAA_4; pfam04326
325240012518	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
325240012519	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
325240012520	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
325240012521	motif II; other site
325240012522	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
325240012523	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
325240012524	active site
325240012525	Int/Topo IB signature motif; other site
325240012526	Protein of unknown function, DUF484; Region: DUF484; cl17449
325240012527	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
325240012528	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
325240012529	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
325240012530	diaminopimelate decarboxylase; Region: lysA; TIGR01048
325240012531	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
325240012532	active site
325240012533	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
325240012534	substrate binding site [chemical binding]; other site
325240012535	catalytic residues [active]
325240012536	dimer interface [polypeptide binding]; other site
325240012537	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627
325240012538	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
325240012539	putative iron binding site [ion binding]; other site
325240012540	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
325240012541	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
325240012542	domain interfaces; other site
325240012543	active site
325240012544	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
325240012545	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
325240012546	active site
325240012547	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
325240012548	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
325240012549	HemY protein N-terminus; Region: HemY_N; pfam07219
325240012550	VCBS repeat; Region: VCBS_repeat; TIGR01965
325240012551	VCBS repeat; Region: VCBS_repeat; TIGR01965
325240012552	VCBS repeat; Region: VCBS_repeat; TIGR01965
325240012553	VCBS repeat; Region: VCBS_repeat; TIGR01965
325240012554	VCBS repeat; Region: VCBS_repeat; TIGR01965
325240012555	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
325240012556	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
325240012557	metal ion-dependent adhesion site (MIDAS); other site
325240012558	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
325240012559	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
325240012560	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
325240012561	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421
325240012562	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
325240012563	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
325240012564	Walker A/P-loop; other site
325240012565	ATP binding site [chemical binding]; other site
325240012566	Q-loop/lid; other site
325240012567	ABC transporter signature motif; other site
325240012568	Walker B; other site
325240012569	D-loop; other site
325240012570	H-loop/switch region; other site
325240012571	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
325240012572	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
325240012573	HlyD family secretion protein; Region: HlyD_3; pfam13437
325240012574	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
325240012575	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
325240012576	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
325240012577	ligand binding site [chemical binding]; other site
325240012578	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
325240012579	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
325240012580	dimerization interface [polypeptide binding]; other site
325240012581	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240012582	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240012583	metal binding site [ion binding]; metal-binding site
325240012584	active site
325240012585	I-site; other site
325240012586	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240012587	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
325240012588	Part of AAA domain; Region: AAA_19; pfam13245
325240012589	Family description; Region: UvrD_C_2; pfam13538
325240012590	Membrane fusogenic activity; Region: BMFP; pfam04380
325240012591	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
325240012592	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
325240012593	inner membrane protein; Provisional; Region: PRK11715
325240012594	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
325240012595	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
325240012596	active site
325240012597	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
325240012598	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
325240012599	substrate binding pocket [chemical binding]; other site
325240012600	membrane-bound complex binding site; other site
325240012601	hinge residues; other site
325240012602	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
325240012603	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
325240012604	putative DNA binding site [nucleotide binding]; other site
325240012605	putative Zn2+ binding site [ion binding]; other site
325240012606	AsnC family; Region: AsnC_trans_reg; pfam01037
325240012607	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
325240012608	Na2 binding site [ion binding]; other site
325240012609	putative substrate binding site 1 [chemical binding]; other site
325240012610	Na binding site 1 [ion binding]; other site
325240012611	putative substrate binding site 2 [chemical binding]; other site
325240012612	Tim44-like domain; Region: Tim44; pfam04280
325240012613	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
325240012614	homodimer interface [polypeptide binding]; other site
325240012615	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240012616	catalytic residue [active]
325240012617	threonine dehydratase; Reviewed; Region: PRK09224
325240012618	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
325240012619	tetramer interface [polypeptide binding]; other site
325240012620	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240012621	catalytic residue [active]
325240012622	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
325240012623	putative Ile/Val binding site [chemical binding]; other site
325240012624	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
325240012625	putative Ile/Val binding site [chemical binding]; other site
325240012626	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
325240012627	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
325240012628	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
325240012629	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
325240012630	PYR/PP interface [polypeptide binding]; other site
325240012631	dimer interface [polypeptide binding]; other site
325240012632	TPP binding site [chemical binding]; other site
325240012633	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
325240012634	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
325240012635	TPP-binding site [chemical binding]; other site
325240012636	dimer interface [polypeptide binding]; other site
325240012637	ketol-acid reductoisomerase; Validated; Region: PRK05225
325240012638	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
325240012639	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
325240012640	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
325240012641	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240012642	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
325240012643	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
325240012644	putative dimerization interface [polypeptide binding]; other site
325240012645	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
325240012646	Domain of unknown function DUF21; Region: DUF21; pfam01595
325240012647	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
325240012648	Transporter associated domain; Region: CorC_HlyC; smart01091
325240012649	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
325240012650	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
325240012651	substrate binding pocket [chemical binding]; other site
325240012652	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
325240012653	GAF domain; Region: GAF; pfam01590
325240012654	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240012655	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240012656	metal binding site [ion binding]; metal-binding site
325240012657	active site
325240012658	I-site; other site
325240012659	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
325240012660	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
325240012661	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240012662	Transposase; Region: HTH_Tnp_1; pfam01527
325240012663	putative transposase OrfB; Reviewed; Region: PHA02517
325240012664	HTH-like domain; Region: HTH_21; pfam13276
325240012665	Integrase core domain; Region: rve; pfam00665
325240012666	Integrase core domain; Region: rve_3; pfam13683
325240012667	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
325240012668	Helix-turn-helix domain; Region: HTH_38; pfam13936
325240012669	Integrase core domain; Region: rve; pfam00665
325240012670	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
325240012671	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
325240012672	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240012673	Walker A motif; other site
325240012674	ATP binding site [chemical binding]; other site
325240012675	Walker B motif; other site
325240012676	arginine finger; other site
325240012677	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
325240012678	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
325240012679	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
325240012680	putative acyl-acceptor binding pocket; other site
325240012681	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
325240012682	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
325240012683	putative acyl-acceptor binding pocket; other site
325240012684	Uncharacterized conserved protein [Function unknown]; Region: COG1683
325240012685	Transcriptional regulators [Transcription]; Region: GntR; COG1802
325240012686	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
325240012687	DNA-binding site [nucleotide binding]; DNA binding site
325240012688	FCD domain; Region: FCD; pfam07729
325240012689	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
325240012690	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
325240012691	tetramer interface [polypeptide binding]; other site
325240012692	active site
325240012693	Mg2+/Mn2+ binding site [ion binding]; other site
325240012694	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
325240012695	dimer interface [polypeptide binding]; other site
325240012696	Citrate synthase; Region: Citrate_synt; pfam00285
325240012697	active site
325240012698	citrylCoA binding site [chemical binding]; other site
325240012699	oxalacetate/citrate binding site [chemical binding]; other site
325240012700	coenzyme A binding site [chemical binding]; other site
325240012701	catalytic triad [active]
325240012702	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
325240012703	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
325240012704	substrate binding site [chemical binding]; other site
325240012705	ligand binding site [chemical binding]; other site
325240012706	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
325240012707	substrate binding site [chemical binding]; other site
325240012708	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
325240012709	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
325240012710	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
325240012711	tetramer interface [polypeptide binding]; other site
325240012712	active site
325240012713	Mg2+/Mn2+ binding site [ion binding]; other site
325240012714	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
325240012715	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
325240012716	PAS fold; Region: PAS_3; pfam08447
325240012717	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240012718	PAS domain; Region: PAS_9; pfam13426
325240012719	putative active site [active]
325240012720	heme pocket [chemical binding]; other site
325240012721	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240012722	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240012723	metal binding site [ion binding]; metal-binding site
325240012724	active site
325240012725	I-site; other site
325240012726	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240012727	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
325240012728	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
325240012729	homodimer interface [polypeptide binding]; other site
325240012730	substrate-cofactor binding pocket; other site
325240012731	catalytic residue [active]
325240012732	Modulator of Rho-dependent transcription termination (ROF); Region: ROF; pfam07073
325240012733	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
325240012734	homotrimer interaction site [polypeptide binding]; other site
325240012735	putative active site [active]
325240012736	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
325240012737	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
325240012738	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
325240012739	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
325240012740	catalytic residues [active]
325240012741	hinge region; other site
325240012742	alpha helical domain; other site
325240012743	serine/threonine protein kinase; Provisional; Region: PRK11768
325240012744	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
325240012745	Protein of unknown function (DUF3630); Region: DUF3630; pfam12305
325240012746	Uncharacterized conserved protein [Function unknown]; Region: COG0397
325240012747	hypothetical protein; Validated; Region: PRK00029
325240012748	DsrE/DsrF-like family; Region: DrsE; cl00672
325240012749	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
325240012750	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
325240012751	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
325240012752	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
325240012753	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
325240012754	DNA-binding site [nucleotide binding]; DNA binding site
325240012755	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
325240012756	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240012757	homodimer interface [polypeptide binding]; other site
325240012758	catalytic residue [active]
325240012759	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
325240012760	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
325240012761	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
325240012762	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
325240012763	catalytic residues [active]
325240012764	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
325240012765	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
325240012766	catalytic residues [active]
325240012767	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
325240012768	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
325240012769	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
325240012770	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
325240012771	DsbD alpha interface [polypeptide binding]; other site
325240012772	catalytic residues [active]
325240012773	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240012774	Coenzyme A binding pocket [chemical binding]; other site
325240012775	Acyltransferase family; Region: Acyl_transf_3; pfam01757
325240012776	Uncharacterized conserved protein [Function unknown]; Region: COG3339
325240012777	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
325240012778	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
325240012779	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
325240012780	substrate binding site [chemical binding]; other site
325240012781	Protein of unknown function (DUF2618); Region: DUF2618; pfam10940
325240012782	ornithine decarboxylase; Provisional; Region: PRK13578
325240012783	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
325240012784	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
325240012785	homodimer interface [polypeptide binding]; other site
325240012786	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240012787	catalytic residue [active]
325240012788	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
325240012789	putrescine transporter; Provisional; Region: potE; PRK10655
325240012790	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
325240012791	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
325240012792	trimer interface [polypeptide binding]; other site
325240012793	eyelet of channel; other site
325240012794	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
325240012795	Shikimate kinase; Region: SKI; pfam01202
325240012796	ATP-binding site [chemical binding]; other site
325240012797	Gluconate-6-phosphate binding site [chemical binding]; other site
325240012798	low affinity gluconate transporter; Provisional; Region: PRK10472
325240012799	GntP family permease; Region: GntP_permease; pfam02447
325240012800	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
325240012801	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
325240012802	DNA binding site [nucleotide binding]
325240012803	domain linker motif; other site
325240012804	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
325240012805	putative ligand binding site [chemical binding]; other site
325240012806	putative dimerization interface [polypeptide binding]; other site
325240012807	hypothetical protein; Provisional; Region: PRK01254
325240012808	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
325240012809	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
325240012810	MAPEG family; Region: MAPEG; cl09190
325240012811	Uncharacterized conserved protein [Function unknown]; Region: COG2966
325240012812	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
325240012813	Uncharacterized conserved protein [Function unknown]; Region: COG3610
325240012814	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
325240012815	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
325240012816	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
325240012817	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
325240012818	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
325240012819	putative SAM binding site [chemical binding]; other site
325240012820	putative homodimer interface [polypeptide binding]; other site
325240012821	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
325240012822	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
325240012823	putative ligand binding site [chemical binding]; other site
325240012824	hypothetical protein; Reviewed; Region: PRK12497
325240012825	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
325240012826	dimer interface [polypeptide binding]; other site
325240012827	active site
325240012828	outer membrane lipoprotein; Provisional; Region: PRK11023
325240012829	BON domain; Region: BON; pfam04972
325240012830	BON domain; Region: BON; pfam04972
325240012831	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
325240012832	EamA-like transporter family; Region: EamA; pfam00892
325240012833	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
325240012834	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
325240012835	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
325240012836	dimerization interface [polypeptide binding]; other site
325240012837	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
325240012838	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
325240012839	active site
325240012840	HIGH motif; other site
325240012841	dimer interface [polypeptide binding]; other site
325240012842	KMSKS motif; other site
325240012843	phosphoglycolate phosphatase; Provisional; Region: PRK13222
325240012844	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
325240012845	motif I; other site
325240012846	active site
325240012847	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
325240012848	motif II; other site
325240012849	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
325240012850	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
325240012851	substrate binding site [chemical binding]; other site
325240012852	hexamer interface [polypeptide binding]; other site
325240012853	metal binding site [ion binding]; metal-binding site
325240012854	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
325240012855	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
325240012856	AAA ATPase domain; Region: AAA_16; pfam13191
325240012857	AAA domain; Region: AAA_22; pfam13401
325240012858	Walker A motif; other site
325240012859	ATP binding site [chemical binding]; other site
325240012860	Walker B motif; other site
325240012861	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
325240012862	active site
325240012863	dimer interface [polypeptide binding]; other site
325240012864	metal binding site [ion binding]; metal-binding site
325240012865	shikimate kinase; Reviewed; Region: aroK; PRK00131
325240012866	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
325240012867	ADP binding site [chemical binding]; other site
325240012868	magnesium binding site [ion binding]; other site
325240012869	putative shikimate binding site; other site
325240012870	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
325240012871	Secretin and TonB N terminus short domain; Region: STN; smart00965
325240012872	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
325240012873	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
325240012874	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
325240012875	Pilus assembly protein, PilP; Region: PilP; pfam04351
325240012876	Pilus assembly protein, PilO; Region: PilO; pfam04350
325240012877	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
325240012878	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
325240012879	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
325240012880	Competence protein A; Region: Competence_A; pfam11104
325240012881	nucleotide binding site [chemical binding]; other site
325240012882	Cell division protein FtsA; Region: FtsA; pfam14450
325240012883	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
325240012884	Transglycosylase; Region: Transgly; pfam00912
325240012885	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
325240012886	argininosuccinate lyase; Provisional; Region: PRK04833
325240012887	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
325240012888	active sites [active]
325240012889	tetramer interface [polypeptide binding]; other site
325240012890	argininosuccinate synthase; Provisional; Region: PRK13820
325240012891	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
325240012892	ANP binding site [chemical binding]; other site
325240012893	Substrate Binding Site II [chemical binding]; other site
325240012894	Substrate Binding Site I [chemical binding]; other site
325240012895	ornithine carbamoyltransferase; Provisional; Region: PRK14805
325240012896	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
325240012897	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
325240012898	acetylglutamate kinase; Provisional; Region: PRK00942
325240012899	nucleotide binding site [chemical binding]; other site
325240012900	substrate binding site [chemical binding]; other site
325240012901	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
325240012902	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
325240012903	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
325240012904	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
325240012905	Protein of unknown function (DUF1439); Region: DUF1439; pfam07273
325240012906	competence damage-inducible protein A; Provisional; Region: PRK00549
325240012907	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
325240012908	putative MPT binding site; other site
325240012909	Competence-damaged protein; Region: CinA; pfam02464
325240012910	putative acetyltransferase; Provisional; Region: PRK03624
325240012911	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240012912	Coenzyme A binding pocket [chemical binding]; other site
325240012913	Helix-turn-helix domain; Region: HTH_17; pfam12728
325240012914	PBP superfamily domain; Region: PBP_like; pfam12727
325240012915	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
325240012916	Protein of unknown function (DUF3305); Region: DUF3305; pfam11749
325240012917	Protein of unknown function (DUF3306); Region: DUF3306; pfam11748
325240012918	Ferredoxin [Energy production and conversion]; Region: COG1146
325240012919	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
325240012920	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
325240012921	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
325240012922	formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811
325240012923	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
325240012924	[4Fe-4S] binding site [ion binding]; other site
325240012925	molybdopterin cofactor binding site; other site
325240012926	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
325240012927	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
325240012928	molybdopterin cofactor binding site; other site
325240012929	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
325240012930	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
325240012931	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
325240012932	formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811
325240012933	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
325240012934	[4Fe-4S] binding site [ion binding]; other site
325240012935	molybdopterin cofactor binding site; other site
325240012936	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
325240012937	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
325240012938	molybdopterin cofactor binding site; other site
325240012939	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
325240012940	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
325240012941	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
325240012942	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
325240012943	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240012944	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
325240012945	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
325240012946	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
325240012947	alphaNTD homodimer interface [polypeptide binding]; other site
325240012948	alphaNTD - beta interaction site [polypeptide binding]; other site
325240012949	alphaNTD - beta' interaction site [polypeptide binding]; other site
325240012950	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
325240012951	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
325240012952	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
325240012953	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
325240012954	RNA binding surface [nucleotide binding]; other site
325240012955	30S ribosomal protein S11; Validated; Region: PRK05309
325240012956	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
325240012957	30S ribosomal protein S13; Region: bact_S13; TIGR03631
325240012958	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
325240012959	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
325240012960	SecY translocase; Region: SecY; pfam00344
325240012961	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
325240012962	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
325240012963	23S rRNA binding site [nucleotide binding]; other site
325240012964	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
325240012965	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
325240012966	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
325240012967	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
325240012968	23S rRNA interface [nucleotide binding]; other site
325240012969	L21e interface [polypeptide binding]; other site
325240012970	5S rRNA interface [nucleotide binding]; other site
325240012971	L27 interface [polypeptide binding]; other site
325240012972	L5 interface [polypeptide binding]; other site
325240012973	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
325240012974	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
325240012975	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
325240012976	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
325240012977	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
325240012978	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
325240012979	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
325240012980	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
325240012981	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
325240012982	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
325240012983	RNA binding site [nucleotide binding]; other site
325240012984	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
325240012985	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
325240012986	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
325240012987	23S rRNA interface [nucleotide binding]; other site
325240012988	putative translocon interaction site; other site
325240012989	signal recognition particle (SRP54) interaction site; other site
325240012990	L23 interface [polypeptide binding]; other site
325240012991	trigger factor interaction site; other site
325240012992	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
325240012993	23S rRNA interface [nucleotide binding]; other site
325240012994	5S rRNA interface [nucleotide binding]; other site
325240012995	putative antibiotic binding site [chemical binding]; other site
325240012996	L25 interface [polypeptide binding]; other site
325240012997	L27 interface [polypeptide binding]; other site
325240012998	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
325240012999	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
325240013000	G-X-X-G motif; other site
325240013001	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
325240013002	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
325240013003	putative translocon binding site; other site
325240013004	protein-rRNA interface [nucleotide binding]; other site
325240013005	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
325240013006	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
325240013007	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
325240013008	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
325240013009	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
325240013010	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
325240013011	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
325240013012	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
325240013013	elongation factor Tu; Reviewed; Region: PRK00049
325240013014	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
325240013015	G1 box; other site
325240013016	GEF interaction site [polypeptide binding]; other site
325240013017	GTP/Mg2+ binding site [chemical binding]; other site
325240013018	Switch I region; other site
325240013019	G2 box; other site
325240013020	G3 box; other site
325240013021	Switch II region; other site
325240013022	G4 box; other site
325240013023	G5 box; other site
325240013024	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
325240013025	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
325240013026	Antibiotic Binding Site [chemical binding]; other site
325240013027	pantothenate kinase; Provisional; Region: PRK05439
325240013028	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
325240013029	ATP-binding site [chemical binding]; other site
325240013030	CoA-binding site [chemical binding]; other site
325240013031	Mg2+-binding site [ion binding]; other site
325240013032	Biotin operon repressor [Transcription]; Region: BirA; COG1654
325240013033	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
325240013034	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
325240013035	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
325240013036	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
325240013037	FAD binding domain; Region: FAD_binding_4; pfam01565
325240013038	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
325240013039	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
325240013040	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
325240013041	glutamate racemase; Provisional; Region: PRK00865
325240013042	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
325240013043	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240013044	S-adenosylmethionine binding site [chemical binding]; other site
325240013045	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
325240013046	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
325240013047	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
325240013048	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
325240013049	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
325240013050	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
325240013051	Fatty acid desaturase; Region: FA_desaturase; pfam00487
325240013052	Di-iron ligands [ion binding]; other site
325240013053	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
325240013054	selenophosphate synthetase; Provisional; Region: PRK00943
325240013055	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
325240013056	dimerization interface [polypeptide binding]; other site
325240013057	putative ATP binding site [chemical binding]; other site
325240013058	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
325240013059	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
325240013060	active site residue [active]
325240013061	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240013062	putative substrate translocation pore; other site
325240013063	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
325240013064	putative acyl-acceptor binding pocket; other site
325240013065	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
325240013066	WHG domain; Region: WHG; pfam13305
325240013067	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
325240013068	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240013069	Coenzyme A binding pocket [chemical binding]; other site
325240013070	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
325240013071	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
325240013072	active site
325240013073	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
325240013074	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
325240013075	dimer interface [polypeptide binding]; other site
325240013076	ADP-ribose binding site [chemical binding]; other site
325240013077	active site
325240013078	nudix motif; other site
325240013079	metal binding site [ion binding]; metal-binding site
325240013080	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
325240013081	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
325240013082	Interdomain contacts; other site
325240013083	Cytokine receptor motif; other site
325240013084	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
325240013085	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
325240013086	Cadherin repeat-like domain; Region: CA_like; cl15786
325240013087	Ca2+ binding site [ion binding]; other site
325240013088	Cadherin repeat-like domain; Region: CA_like; cl15786
325240013089	Ca2+ binding site [ion binding]; other site
325240013090	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
325240013091	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
325240013092	Phage Tail Collar Domain; Region: Collar; pfam07484
325240013093	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
325240013094	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
325240013095	Coenzyme A binding pocket [chemical binding]; other site
325240013096	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240013097	S-adenosylmethionine binding site [chemical binding]; other site
325240013098	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
325240013099	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
325240013100	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
325240013101	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
325240013102	motif II; other site
325240013103	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
325240013104	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
325240013105	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
325240013106	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
325240013107	GspL periplasmic domain; Region: GspL_C; pfam12693
325240013108	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
325240013109	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
325240013110	type II secretion system protein J; Region: gspJ; TIGR01711
325240013111	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
325240013112	Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963
325240013113	type II secretion system protein I; Region: gspI; TIGR01707
325240013114	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
325240013115	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
325240013116	Type II transport protein GspH; Region: GspH; pfam12019
325240013117	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
325240013118	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
325240013119	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
325240013120	type II secretion system protein F; Region: GspF; TIGR02120
325240013121	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
325240013122	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
325240013123	type II secretion system protein E; Region: type_II_gspE; TIGR02533
325240013124	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
325240013125	Walker A motif; other site
325240013126	ATP binding site [chemical binding]; other site
325240013127	Walker B motif; other site
325240013128	type II secretion system protein D; Region: type_II_gspD; TIGR02517
325240013129	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
325240013130	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
325240013131	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
325240013132	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
325240013133	putative type II secretion protein GspC; Provisional; Region: PRK09681
325240013134	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
325240013135	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
325240013136	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
325240013137	RNA binding surface [nucleotide binding]; other site
325240013138	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
325240013139	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
325240013140	dimerization interface [polypeptide binding]; other site
325240013141	domain crossover interface; other site
325240013142	redox-dependent activation switch; other site
325240013143	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
325240013144	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
325240013145	active site
325240013146	substrate-binding site [chemical binding]; other site
325240013147	metal-binding site [ion binding]
325240013148	ATP binding site [chemical binding]; other site
325240013149	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
325240013150	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
325240013151	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
325240013152	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241
325240013153	putative active site [active]
325240013154	Zn binding site [ion binding]; other site
325240013155	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240013156	S-adenosylmethionine binding site [chemical binding]; other site
325240013157	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
325240013158	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
325240013159	GIY-YIG motif/motif A; other site
325240013160	putative active site [active]
325240013161	putative metal binding site [ion binding]; other site
325240013162	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
325240013163	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
325240013164	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
325240013165	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
325240013166	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
325240013167	Nitrate and nitrite sensing; Region: NIT; pfam08376
325240013168	Nitrate and nitrite sensing; Region: NIT; pfam08376
325240013169	HAMP domain; Region: HAMP; pfam00672
325240013170	dimerization interface [polypeptide binding]; other site
325240013171	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
325240013172	PAS domain; Region: PAS_9; pfam13426
325240013173	putative active site [active]
325240013174	heme pocket [chemical binding]; other site
325240013175	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
325240013176	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
325240013177	metal binding site [ion binding]; metal-binding site
325240013178	active site
325240013179	I-site; other site
325240013180	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
325240013181	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
325240013182	Ferritin-like domain; Region: Ferritin; pfam00210
325240013183	ferroxidase diiron center [ion binding]; other site
325240013184	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
325240013185	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
325240013186	dimer interface [polypeptide binding]; other site
325240013187	putative functional site; other site
325240013188	putative MPT binding site; other site
325240013189	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
325240013190	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
325240013191	ATP binding site [chemical binding]; other site
325240013192	substrate interface [chemical binding]; other site
325240013193	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
325240013194	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
325240013195	Domain of unknown function (DUF333); Region: DUF333; pfam03891
325240013196	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
325240013197	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240013198	S-adenosylmethionine binding site [chemical binding]; other site
325240013199	flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697
325240013200	Chorismate lyase; Region: Chor_lyase; cl01230
325240013201	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
325240013202	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
325240013203	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
325240013204	putative antibiotic transporter; Provisional; Region: PRK10739
325240013205	NRDE protein; Region: NRDE; cl01315
325240013206	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
325240013207	SnoaL-like domain; Region: SnoaL_3; pfam13474
325240013208	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
325240013209	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
325240013210	putative acyl-acceptor binding pocket; other site
325240013211	LysE type translocator; Region: LysE; cl00565
325240013212	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
325240013213	Mechanosensitive ion channel; Region: MS_channel; pfam00924
325240013214	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
325240013215	Protein of unknown function (DUF3157); Region: DUF3157; pfam11355
325240013216	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
325240013217	Peptidase family M23; Region: Peptidase_M23; pfam01551
325240013218	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
325240013219	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
325240013220	Peptidase family M48; Region: Peptidase_M48; cl12018
325240013221	Pilin (bacterial filament); Region: Pilin; pfam00114
325240013222	Protein of unknown function (DUF2000); Region: DUF2000; cl02074
325240013223	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
325240013224	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
325240013225	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
325240013226	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
325240013227	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
325240013228	AzlC protein; Region: AzlC; cl00570
325240013229	transaminase; Validated; Region: PRK07324
325240013230	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
325240013231	pyridoxal 5'-phosphate binding site [chemical binding]; other site
325240013232	homodimer interface [polypeptide binding]; other site
325240013233	catalytic residue [active]
325240013234	Biofilm formation and stress response factor; Region: BsmA; pfam10014
325240013235	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
325240013236	active sites [active]
325240013237	tetramer interface [polypeptide binding]; other site
325240013238	urocanate hydratase; Provisional; Region: PRK05414
325240013239	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
325240013240	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
325240013241	DNA-binding site [nucleotide binding]; DNA binding site
325240013242	UTRA domain; Region: UTRA; pfam07702
325240013243	imidazolonepropionase; Validated; Region: PRK09356
325240013244	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
325240013245	active site
325240013246	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
325240013247	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
325240013248	FAD binding pocket [chemical binding]; other site
325240013249	FAD binding motif [chemical binding]; other site
325240013250	phosphate binding motif [ion binding]; other site
325240013251	NAD binding pocket [chemical binding]; other site
325240013252	Transcriptional regulators [Transcription]; Region: MarR; COG1846
325240013253	MarR family; Region: MarR_2; pfam12802
325240013254	MarR family; Region: MarR_2; cl17246
325240013255	Lamin Tail Domain; Region: LTD; pfam00932
325240013256	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
325240013257	Endonuclease I; Region: Endonuclease_1; pfam04231
325240013258	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
325240013259	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110
325240013260	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
325240013261	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
325240013262	putative active site [active]
325240013263	catalytic site [active]
325240013264	putative metal binding site [ion binding]; other site
325240013265	Protein of unknown function (DUF3137); Region: DUF3137; pfam11335
325240013266	2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691
325240013267	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
325240013268	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
325240013269	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
325240013270	DNA binding residues [nucleotide binding]
325240013271	putative dimer interface [polypeptide binding]; other site
325240013272	Uncharacterized conserved protein [Function unknown]; Region: COG3791
325240013273	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
325240013274	active site
325240013275	Protein of unknown function (DUF3233); Region: DUF3233; pfam11557
325240013276	HPP family; Region: HPP; pfam04982
325240013277	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
325240013278	active site
325240013279	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
325240013280	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
325240013281	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
325240013282	acyl-activating enzyme (AAE) consensus motif; other site
325240013283	putative AMP binding site [chemical binding]; other site
325240013284	putative active site [active]
325240013285	putative CoA binding site [chemical binding]; other site
325240013286	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
325240013287	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
325240013288	Walker A/P-loop; other site
325240013289	ATP binding site [chemical binding]; other site
325240013290	Q-loop/lid; other site
325240013291	ABC transporter signature motif; other site
325240013292	Walker B; other site
325240013293	D-loop; other site
325240013294	H-loop/switch region; other site
325240013295	Predicted transcriptional regulators [Transcription]; Region: COG1725
325240013296	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
325240013297	DNA-binding site [nucleotide binding]; DNA binding site
325240013298	TAP-like protein; Region: Abhydrolase_4; pfam08386
325240013299	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
325240013300	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
325240013301	Walker A/P-loop; other site
325240013302	ATP binding site [chemical binding]; other site
325240013303	Q-loop/lid; other site
325240013304	ABC transporter signature motif; other site
325240013305	Walker B; other site
325240013306	D-loop; other site
325240013307	H-loop/switch region; other site
325240013308	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
325240013309	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
325240013310	Phage shock protein B; Region: PspB; cl05946
325240013311	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
325240013312	Transglycosylase; Region: Transgly; pfam00912
325240013313	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
325240013314	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
325240013315	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
325240013316	MG2 domain; Region: A2M_N; pfam01835
325240013317	Alpha-2-macroglobulin family; Region: A2M; pfam00207
325240013318	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
325240013319	surface patch; other site
325240013320	thioester region; other site
325240013321	specificity defining residues; other site
325240013322	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
325240013323	MPT binding site; other site
325240013324	trimer interface [polypeptide binding]; other site
325240013325	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
325240013326	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
325240013327	putative substrate binding site [chemical binding]; other site
325240013328	putative ATP binding site [chemical binding]; other site
325240013329	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
325240013330	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
325240013331	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
325240013332	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
325240013333	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240013334	putative substrate translocation pore; other site
325240013335	sucrose phosphorylase; Provisional; Region: PRK13840
325240013336	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
325240013337	active site
325240013338	homodimer interface [polypeptide binding]; other site
325240013339	catalytic site [active]
325240013340	putative transposase OrfB; Reviewed; Region: PHA02517
325240013341	HTH-like domain; Region: HTH_21; pfam13276
325240013342	Integrase core domain; Region: rve; pfam00665
325240013343	Integrase core domain; Region: rve_3; pfam13683
325240013344	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240013345	Transposase; Region: HTH_Tnp_1; pfam01527
325240013346	Integrase core domain; Region: rve; pfam00665
325240013347	Integrase core domain; Region: rve_3; pfam13683
325240013348	Transcriptional regulators [Transcription]; Region: PurR; COG1609
325240013349	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
325240013350	DNA binding site [nucleotide binding]
325240013351	domain linker motif; other site
325240013352	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
325240013353	putative dimerization interface [polypeptide binding]; other site
325240013354	putative ligand binding site [chemical binding]; other site
325240013355	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
325240013356	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
325240013357	putative substrate translocation pore; other site
325240013358	NlpC/P60 family; Region: NLPC_P60; pfam00877
325240013359	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
325240013360	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
325240013361	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
325240013362	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240013363	active site
325240013364	phosphorylation site [posttranslational modification]
325240013365	intermolecular recognition site; other site
325240013366	dimerization interface [polypeptide binding]; other site
325240013367	LytTr DNA-binding domain; Region: LytTR; pfam04397
325240013368	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
325240013369	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
325240013370	GAF domain; Region: GAF_3; pfam13492
325240013371	Histidine kinase; Region: His_kinase; pfam06580
325240013372	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240013373	ATP binding site [chemical binding]; other site
325240013374	Mg2+ binding site [ion binding]; other site
325240013375	G-X-G motif; other site
325240013376	Pirin-related protein [General function prediction only]; Region: COG1741
325240013377	Pirin; Region: Pirin; pfam02678
325240013378	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
325240013379	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
325240013380	dimer interface [polypeptide binding]; other site
325240013381	phosphorylation site [posttranslational modification]
325240013382	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
325240013383	ATP binding site [chemical binding]; other site
325240013384	Mg2+ binding site [ion binding]; other site
325240013385	G-X-G motif; other site
325240013386	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
325240013387	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
325240013388	active site
325240013389	phosphorylation site [posttranslational modification]
325240013390	intermolecular recognition site; other site
325240013391	dimerization interface [polypeptide binding]; other site
325240013392	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
325240013393	DNA binding site [nucleotide binding]
325240013394	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
325240013395	TrkA-N domain; Region: TrkA_N; pfam02254
325240013396	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
325240013397	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
325240013398	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
325240013399	Mg2+ binding site [ion binding]; other site
325240013400	G-X-G motif; other site
325240013401	Transposase; Region: HTH_Tnp_1; pfam01527
325240013402	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
325240013403	Transposase; Region: HTH_Tnp_1; cl17663
325240013404	putative transposase OrfB; Reviewed; Region: PHA02517
325240013405	Homeodomain-like domain; Region: HTH_32; pfam13565
325240013406	Integrase core domain; Region: rve; pfam00665
325240013407	Integrase core domain; Region: rve_3; pfam13683
325240013408	HTH-like domain; Region: HTH_21; pfam13276
325240013409	Integrase core domain; Region: rve; pfam00665
325240013410	Integrase core domain; Region: rve_2; pfam13333
325240013411	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
325240013412	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
325240013413	Winged helix-turn helix; Region: HTH_29; pfam13551
325240013414	Homeodomain-like domain; Region: HTH_32; pfam13565
325240013415	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
325240013416	Integrase core domain; Region: rve; pfam00665
325240013417	Integrase core domain; Region: rve_3; pfam13683
325240013418	Transposase; Region: HTH_Tnp_1; cl17663
325240013419	AAA domain; Region: AAA_22; pfam13401
325240013420	AAA ATPase domain; Region: AAA_16; pfam13191
325240013421	Walker A motif; other site
325240013422	ATP binding site [chemical binding]; other site
325240013423	Walker B motif; other site
325240013424	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240013425	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240013426	Walker A motif; other site
325240013427	ATP binding site [chemical binding]; other site
325240013428	Walker B motif; other site
325240013429	Integrase core domain; Region: rve; pfam00665
325240013430	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
325240013431	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
325240013432	HI0933-like protein; Region: HI0933_like; pfam03486
325240013433	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
325240013434	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
325240013435	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
325240013436	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
325240013437	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
325240013438	SecA binding site; other site
325240013439	Preprotein binding site; other site
325240013440	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
325240013441	active site residue [active]
325240013442	phosphoglyceromutase; Provisional; Region: PRK05434
325240013443	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
325240013444	AmiB activator; Provisional; Region: PRK11637
325240013445	Peptidase family M23; Region: Peptidase_M23; pfam01551
325240013446	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
325240013447	C-terminal peptidase (prc); Region: prc; TIGR00225
325240013448	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
325240013449	protein binding site [polypeptide binding]; other site
325240013450	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
325240013451	Catalytic dyad [active]
325240013452	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
325240013453	putative active site [active]
325240013454	putative catalytic site [active]
325240013455	NodB motif; other site
325240013456	Zn binding site [ion binding]; other site
325240013457	Transcriptional regulator; Region: Rrf2; cl17282
325240013458	Rrf2 family protein; Region: rrf2_super; TIGR00738
325240013459	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
325240013460	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
325240013461	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
325240013462	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
325240013463	substrate binding site [chemical binding]; other site
325240013464	oxyanion hole (OAH) forming residues; other site
325240013465	trimer interface [polypeptide binding]; other site
325240013466	Predicted membrane protein [Function unknown]; Region: COG3205
325240013467	Integrase core domain; Region: rve; pfam00665
325240013468	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
325240013469	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240013470	Walker A motif; other site
325240013471	ATP binding site [chemical binding]; other site
325240013472	Walker B motif; other site
325240013473	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
325240013474	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
325240013475	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
325240013476	ATP binding site [chemical binding]; other site
325240013477	putative Mg++ binding site [ion binding]; other site
325240013478	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
325240013479	DNA protecting protein DprA; Region: dprA; TIGR00732
325240013480	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
325240013481	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
325240013482	ATP binding site [chemical binding]; other site
325240013483	putative Mg++ binding site [ion binding]; other site
325240013484	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
325240013485	nucleotide binding region [chemical binding]; other site
325240013486	ATP-binding site [chemical binding]; other site
325240013487	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
325240013488	active site
325240013489	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
325240013490	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
325240013491	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
325240013492	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
325240013493	Winged helix-turn helix; Region: HTH_29; pfam13551
325240013494	Homeodomain-like domain; Region: HTH_32; pfam13565
325240013495	Integrase core domain; Region: rve; pfam00665
325240013496	DDE domain; Region: DDE_Tnp_IS240; pfam13610
325240013497	Integrase core domain; Region: rve_3; pfam13683
325240013498	Helix-turn-helix domain; Region: HTH_28; pfam13518
325240013499	HsdM N-terminal domain; Region: HsdM_N; pfam12161
325240013500	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
325240013501	Methyltransferase domain; Region: Methyltransf_26; pfam13659
325240013502	Helix-turn-helix domain; Region: HTH_17; pfam12728
325240013503	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
325240013504	putative active site [active]
325240013505	metal binding site [ion binding]; metal-binding site
325240013506	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
325240013507	salt bridge; other site
325240013508	non-specific DNA binding site [nucleotide binding]; other site
325240013509	sequence-specific DNA binding site [nucleotide binding]; other site
325240013510	AAA domain; Region: AAA_22; pfam13401
325240013511	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
325240013512	Walker A motif; other site
325240013513	ATP binding site [chemical binding]; other site
325240013514	Walker B motif; other site
325240013515	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208
325240013516	CAS motifs; other site
325240013517	active site
325240013518	Tn7 transposition regulator TnsC; Region: Tn7_TnsC_Int; pfam11426
325240013519	Integrase core domain; Region: rve; pfam00665
325240013520	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
325240013521	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
325240013522	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
325240013523	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
325240013524	glutaminase active site [active]
325240013525	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
325240013526	dimer interface [polypeptide binding]; other site
325240013527	active site
325240013528	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
325240013529	dimer interface [polypeptide binding]; other site
325240013530	active site
325240013531	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
325240013532	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
325240013533	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
325240013534	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
325240013535	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
325240013536	N-terminal plug; other site
325240013537	ligand-binding site [chemical binding]; other site
325240013538	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
325240013539	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
325240013540	Substrate binding site; other site
325240013541	Mg++ binding site; other site
325240013542	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
325240013543	active site
325240013544	substrate binding site [chemical binding]; other site
325240013545	CoA binding site [chemical binding]; other site
325240013546	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
325240013547	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
325240013548	gamma subunit interface [polypeptide binding]; other site
325240013549	epsilon subunit interface [polypeptide binding]; other site
325240013550	LBP interface [polypeptide binding]; other site
325240013551	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
325240013552	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
325240013553	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
325240013554	alpha subunit interaction interface [polypeptide binding]; other site
325240013555	Walker A motif; other site
325240013556	ATP binding site [chemical binding]; other site
325240013557	Walker B motif; other site
325240013558	inhibitor binding site; inhibition site
325240013559	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
325240013560	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
325240013561	core domain interface [polypeptide binding]; other site
325240013562	delta subunit interface [polypeptide binding]; other site
325240013563	epsilon subunit interface [polypeptide binding]; other site
325240013564	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
325240013565	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
325240013566	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
325240013567	beta subunit interaction interface [polypeptide binding]; other site
325240013568	Walker A motif; other site
325240013569	ATP binding site [chemical binding]; other site
325240013570	Walker B motif; other site
325240013571	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
325240013572	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
325240013573	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
325240013574	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
325240013575	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
325240013576	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
325240013577	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
325240013578	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
325240013579	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
325240013580	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
325240013581	ParB-like nuclease domain; Region: ParBc; pfam02195
325240013582	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
325240013583	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
325240013584	P-loop; other site
325240013585	Magnesium ion binding site [ion binding]; other site
325240013586	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
325240013587	Magnesium ion binding site [ion binding]; other site
325240013588	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
325240013589	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
325240013590	S-adenosylmethionine binding site [chemical binding]; other site
325240013591	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
325240013592	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
325240013593	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
325240013594	FMN-binding protein MioC; Provisional; Region: PRK09004
325240013595	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
325240013596	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
325240013597	trmE is a tRNA modification GTPase; Region: trmE; cd04164
325240013598	G1 box; other site
325240013599	GTP/Mg2+ binding site [chemical binding]; other site
325240013600	Switch I region; other site
325240013601	G2 box; other site
325240013602	Switch II region; other site
325240013603	G3 box; other site
325240013604	G4 box; other site
325240013605	G5 box; other site
325240013606	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
325240013607	membrane protein insertase; Provisional; Region: PRK01318
325240013608	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
325240013609	Haemolytic domain; Region: Haemolytic; pfam01809
325240013610	ribonuclease P; Reviewed; Region: rnpA; PRK01732
325240013611	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399