-- dump date 20140620_064143 -- class Genbank::misc_feature -- table misc_feature_note -- id note 211586000001 FMN-binding protein MioC; Provisional; Region: PRK09004 211586000002 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 211586000003 POT family; Region: PTR2; cl17359 211586000004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586000005 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 211586000006 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 211586000007 trmE is a tRNA modification GTPase; Region: trmE; cd04164 211586000008 G1 box; other site 211586000009 GTP/Mg2+ binding site [chemical binding]; other site 211586000010 Switch I region; other site 211586000011 G2 box; other site 211586000012 Switch II region; other site 211586000013 G3 box; other site 211586000014 G4 box; other site 211586000015 G5 box; other site 211586000016 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 211586000017 membrane protein insertase; Provisional; Region: PRK01318 211586000018 YidC periplasmic domain; Region: YidC_periplas; pfam14849 211586000019 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 211586000020 Haemolytic domain; Region: Haemolytic; pfam01809 211586000021 ribonuclease P; Reviewed; Region: rnpA; PRK01732 211586000022 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 211586000023 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 211586000024 DnaA N-terminal domain; Region: DnaA_N; pfam11638 211586000025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586000026 Walker A motif; other site 211586000027 ATP binding site [chemical binding]; other site 211586000028 Walker B motif; other site 211586000029 arginine finger; other site 211586000030 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 211586000031 DnaA box-binding interface [nucleotide binding]; other site 211586000032 DNA polymerase III subunit beta; Validated; Region: PRK05643 211586000033 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 211586000034 putative DNA binding surface [nucleotide binding]; other site 211586000035 dimer interface [polypeptide binding]; other site 211586000036 beta-clamp/clamp loader binding surface; other site 211586000037 beta-clamp/translesion DNA polymerase binding surface; other site 211586000038 recombination protein F; Reviewed; Region: recF; PRK00064 211586000039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211586000040 Walker A/P-loop; other site 211586000041 ATP binding site [chemical binding]; other site 211586000042 Q-loop/lid; other site 211586000043 ABC transporter signature motif; other site 211586000044 Walker B; other site 211586000045 D-loop; other site 211586000046 H-loop/switch region; other site 211586000047 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 211586000048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586000049 ATP binding site [chemical binding]; other site 211586000050 Mg2+ binding site [ion binding]; other site 211586000051 G-X-G motif; other site 211586000052 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 211586000053 anchoring element; other site 211586000054 dimer interface [polypeptide binding]; other site 211586000055 ATP binding site [chemical binding]; other site 211586000056 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 211586000057 active site 211586000058 putative metal-binding site [ion binding]; other site 211586000059 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 211586000060 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 211586000061 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 211586000062 putative C-terminal domain interface [polypeptide binding]; other site 211586000063 putative GSH binding site (G-site) [chemical binding]; other site 211586000064 putative dimer interface [polypeptide binding]; other site 211586000065 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 211586000066 putative N-terminal domain interface [polypeptide binding]; other site 211586000067 putative dimer interface [polypeptide binding]; other site 211586000068 putative substrate binding pocket (H-site) [chemical binding]; other site 211586000069 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 211586000070 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211586000071 Zn2+ binding site [ion binding]; other site 211586000072 Mg2+ binding site [ion binding]; other site 211586000073 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 211586000074 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 211586000075 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 211586000076 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 211586000077 dimer interface [polypeptide binding]; other site 211586000078 motif 1; other site 211586000079 active site 211586000080 motif 2; other site 211586000081 motif 3; other site 211586000082 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 211586000083 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 211586000084 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 211586000085 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 211586000086 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 211586000087 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 211586000088 active site 211586000089 MOSC domain; Region: MOSC; pfam03473 211586000090 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 211586000091 CPxP motif; other site 211586000092 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 211586000093 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 211586000094 dimer interface [polypeptide binding]; other site 211586000095 active site 211586000096 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 211586000097 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 211586000098 substrate binding site [chemical binding]; other site 211586000099 oxyanion hole (OAH) forming residues; other site 211586000100 trimer interface [polypeptide binding]; other site 211586000101 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 211586000102 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 211586000103 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 211586000104 proline dipeptidase; Provisional; Region: PRK13607 211586000105 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 211586000106 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 211586000107 active site 211586000108 hypothetical protein; Provisional; Region: PRK11568 211586000109 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 211586000110 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 211586000111 Cation transport protein; Region: TrkH; cl17365 211586000112 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 211586000113 Flavodoxin domain; Region: Flavodoxin_5; cl17428 211586000114 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 211586000115 dimerization interface [polypeptide binding]; other site 211586000116 putative DNA binding site [nucleotide binding]; other site 211586000117 putative Zn2+ binding site [ion binding]; other site 211586000118 Flavodoxin domain; Region: Flavodoxin_5; cl17428 211586000119 Cation transport protein; Region: TrkH; cl17365 211586000120 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 211586000121 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 211586000122 TrkA-N domain; Region: TrkA_N; pfam02254 211586000123 TrkA-C domain; Region: TrkA_C; pfam02080 211586000124 TrkA-N domain; Region: TrkA_N; pfam02254 211586000125 TrkA-C domain; Region: TrkA_C; pfam02080 211586000126 16S rRNA methyltransferase B; Provisional; Region: PRK10901 211586000127 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 211586000128 putative RNA binding site [nucleotide binding]; other site 211586000129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586000130 S-adenosylmethionine binding site [chemical binding]; other site 211586000131 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 211586000132 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 211586000133 putative active site [active] 211586000134 substrate binding site [chemical binding]; other site 211586000135 putative cosubstrate binding site; other site 211586000136 catalytic site [active] 211586000137 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 211586000138 substrate binding site [chemical binding]; other site 211586000139 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 211586000140 active site 211586000141 catalytic residues [active] 211586000142 metal binding site [ion binding]; metal-binding site 211586000143 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 211586000144 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 211586000145 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 211586000146 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 211586000147 Protein of unknown function (DUF494); Region: DUF494; pfam04361 211586000148 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 211586000149 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 211586000150 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 211586000151 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 211586000152 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 211586000153 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 211586000154 apolar tunnel; other site 211586000155 heme binding site [chemical binding]; other site 211586000156 dimerization interface [polypeptide binding]; other site 211586000157 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 211586000158 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 211586000159 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 211586000160 shikimate binding site; other site 211586000161 NAD(P) binding site [chemical binding]; other site 211586000162 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 211586000163 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 211586000164 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 211586000165 trimer interface [polypeptide binding]; other site 211586000166 putative metal binding site [ion binding]; other site 211586000167 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 211586000168 Transcriptional regulator; Region: Rrf2; cl17282 211586000169 Rrf2 family protein; Region: rrf2_super; TIGR00738 211586000170 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 211586000171 NodB motif; other site 211586000172 putative active site [active] 211586000173 putative catalytic site [active] 211586000174 Zn binding site [ion binding]; other site 211586000175 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 211586000176 C-terminal peptidase (prc); Region: prc; TIGR00225 211586000177 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 211586000178 protein binding site [polypeptide binding]; other site 211586000179 Catalytic dyad [active] 211586000180 AmiB activator; Provisional; Region: PRK11637 211586000181 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 211586000182 Intraflagellar transport complex B, subunit 20; Region: IFT20; pfam14931 211586000183 Peptidase family M23; Region: Peptidase_M23; pfam01551 211586000184 phosphoglyceromutase; Provisional; Region: PRK05434 211586000185 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 211586000186 active site residue [active] 211586000187 preprotein translocase subunit SecB; Validated; Region: PRK05751 211586000188 SecA binding site; other site 211586000189 Preprotein binding site; other site 211586000190 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 211586000191 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 211586000192 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 211586000193 HI0933-like protein; Region: HI0933_like; pfam03486 211586000194 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 211586000195 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 211586000196 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 211586000197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586000198 binding surface 211586000199 TPR motif; other site 211586000200 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211586000201 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211586000202 substrate binding pocket [chemical binding]; other site 211586000203 membrane-bound complex binding site; other site 211586000204 hinge residues; other site 211586000205 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 211586000206 Cation transport protein; Region: TrkH; pfam02386 211586000207 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 211586000208 TrkA-N domain; Region: TrkA_N; pfam02254 211586000209 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211586000210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586000211 active site 211586000212 phosphorylation site [posttranslational modification] 211586000213 intermolecular recognition site; other site 211586000214 dimerization interface [polypeptide binding]; other site 211586000215 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211586000216 DNA binding site [nucleotide binding] 211586000217 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 211586000218 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211586000219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586000220 dimer interface [polypeptide binding]; other site 211586000221 phosphorylation site [posttranslational modification] 211586000222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586000223 ATP binding site [chemical binding]; other site 211586000224 Mg2+ binding site [ion binding]; other site 211586000225 G-X-G motif; other site 211586000226 NlpC/P60 family; Region: NLPC_P60; pfam00877 211586000227 HipA N-terminal domain; Region: Couple_hipA; pfam13657 211586000228 HipA-like N-terminal domain; Region: HipA_N; pfam07805 211586000229 HipA-like C-terminal domain; Region: HipA_C; pfam07804 211586000230 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 211586000231 MPT binding site; other site 211586000232 trimer interface [polypeptide binding]; other site 211586000233 Bacterial Ig-like domain; Region: Big_5; pfam13205 211586000234 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 211586000235 MG2 domain; Region: A2M_N; pfam01835 211586000236 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 211586000237 Alpha-2-macroglobulin family; Region: A2M; pfam00207 211586000238 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 211586000239 surface patch; other site 211586000240 thioester region; other site 211586000241 specificity defining residues; other site 211586000242 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 211586000243 Transglycosylase; Region: Transgly; pfam00912 211586000244 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 211586000245 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 211586000246 Phage shock protein B; Region: PspB; cl05946 211586000247 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 211586000248 Acyltransferase family; Region: Acyl_transf_3; cl19154 211586000249 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 211586000250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211586000251 Walker A/P-loop; other site 211586000252 ATP binding site [chemical binding]; other site 211586000253 Q-loop/lid; other site 211586000254 ABC transporter signature motif; other site 211586000255 Walker B; other site 211586000256 D-loop; other site 211586000257 H-loop/switch region; other site 211586000258 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 211586000259 Putative lysophospholipase; Region: Hydrolase_4; cl19140 211586000260 TAP-like protein; Region: Abhydrolase_4; pfam08386 211586000261 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 211586000262 Predicted transcriptional regulators [Transcription]; Region: COG1725 211586000263 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 211586000264 DNA-binding site [nucleotide binding]; DNA binding site 211586000265 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 211586000266 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 211586000267 Walker A/P-loop; other site 211586000268 ATP binding site [chemical binding]; other site 211586000269 Q-loop/lid; other site 211586000270 ABC transporter signature motif; other site 211586000271 Walker B; other site 211586000272 D-loop; other site 211586000273 H-loop/switch region; other site 211586000274 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 211586000275 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 211586000276 acyl-activating enzyme (AAE) consensus motif; other site 211586000277 putative AMP binding site [chemical binding]; other site 211586000278 putative active site [active] 211586000279 putative CoA binding site [chemical binding]; other site 211586000280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 211586000281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 211586000282 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 211586000283 active site 211586000284 Predicted acetyltransferase [General function prediction only]; Region: COG2388 211586000285 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586000286 Coenzyme A binding pocket [chemical binding]; other site 211586000287 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 211586000288 active site 211586000289 Uncharacterized conserved protein [Function unknown]; Region: COG3791 211586000290 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 211586000291 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 211586000292 DNA binding residues [nucleotide binding] 211586000293 putative dimer interface [polypeptide binding]; other site 211586000294 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 211586000295 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 211586000296 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 211586000297 Putative phosphatase (DUF442); Region: DUF442; cl17385 211586000298 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 211586000299 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 211586000300 ligand binding site [chemical binding]; other site 211586000301 flexible hinge region; other site 211586000302 purine nucleoside phosphorylase; Provisional; Region: PRK13374 211586000303 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 211586000304 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 211586000305 Nucleoside recognition; Region: Gate; pfam07670 211586000306 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 211586000307 imidazolonepropionase; Validated; Region: PRK09356 211586000308 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 211586000309 active site 211586000310 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 211586000311 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 211586000312 DNA-binding site [nucleotide binding]; DNA binding site 211586000313 UTRA domain; Region: UTRA; pfam07702 211586000314 urocanate hydratase; Provisional; Region: PRK05414 211586000315 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 211586000316 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 211586000317 active sites [active] 211586000318 tetramer interface [polypeptide binding]; other site 211586000319 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 211586000320 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 211586000321 [4Fe-4S] binding site [ion binding]; other site 211586000322 molybdopterin cofactor binding site; other site 211586000323 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 211586000324 molybdopterin cofactor binding site; other site 211586000325 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 211586000326 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 211586000327 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 211586000328 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 211586000329 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 211586000330 selenocysteine synthase; Provisional; Region: PRK04311 211586000331 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 211586000332 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 211586000333 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 211586000334 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 211586000335 G1 box; other site 211586000336 putative GEF interaction site [polypeptide binding]; other site 211586000337 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 211586000338 GTP/Mg2+ binding site [chemical binding]; other site 211586000339 Switch I region; other site 211586000340 G2 box; other site 211586000341 G3 box; other site 211586000342 Switch II region; other site 211586000343 G4 box; other site 211586000344 G5 box; other site 211586000345 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 211586000346 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 211586000347 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 211586000348 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 211586000349 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 211586000350 putative inner membrane protein; Provisional; Region: PRK11099 211586000351 Predicted transporter component [General function prediction only]; Region: COG2391 211586000352 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 211586000353 CPxP motif; other site 211586000354 Peptidase family M48; Region: Peptidase_M48; cl12018 211586000355 Pilin (bacterial filament); Region: Pilin; pfam00114 211586000356 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 211586000357 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 211586000358 Protein of unknown function, DUF481; Region: DUF481; cl01213 211586000359 Protein of unknown function (DUF3157); Region: DUF3157; pfam11355 211586000360 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 211586000361 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 211586000362 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 211586000363 Mechanosensitive ion channel; Region: MS_channel; pfam00924 211586000364 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 211586000365 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 211586000366 putative acyl-acceptor binding pocket; other site 211586000367 Domain of unknown function (DUF4440); Region: DUF4440; pfam14534 211586000368 NRDE protein; Region: NRDE; cl01315 211586000369 Selenoprotein P, N terminal region; Region: SelP_N; pfam04592 211586000370 MarC family integral membrane protein; Region: MarC; cl00919 211586000371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 211586000372 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 211586000373 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 211586000374 FOG: PKD repeat [General function prediction only]; Region: COG3291 211586000375 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 211586000376 Chorismate lyase; Region: Chor_lyase; cl01230 211586000377 flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697 211586000378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586000379 S-adenosylmethionine binding site [chemical binding]; other site 211586000380 Domain of unknown function (DUF333); Region: DUF333; pfam03891 211586000381 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 211586000382 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 211586000383 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 211586000384 ATP binding site [chemical binding]; other site 211586000385 substrate interface [chemical binding]; other site 211586000386 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 211586000387 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 211586000388 dimer interface [polypeptide binding]; other site 211586000389 putative functional site; other site 211586000390 putative MPT binding site; other site 211586000391 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 211586000392 Ferritin-like domain; Region: Ferritin; pfam00210 211586000393 ferroxidase diiron center [ion binding]; other site 211586000394 Nitrate and nitrite sensing; Region: NIT; pfam08376 211586000395 CHASE3 domain; Region: CHASE3; cl05000 211586000396 HAMP domain; Region: HAMP; pfam00672 211586000397 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586000398 PAS domain; Region: PAS_9; pfam13426 211586000399 putative active site [active] 211586000400 heme pocket [chemical binding]; other site 211586000401 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586000402 metal binding site [ion binding]; metal-binding site 211586000403 active site 211586000404 I-site; other site 211586000405 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586000406 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 211586000407 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 211586000408 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 211586000409 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 211586000410 GIY-YIG motif/motif A; other site 211586000411 putative active site [active] 211586000412 putative metal binding site [ion binding]; other site 211586000413 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586000414 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 211586000415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586000416 S-adenosylmethionine binding site [chemical binding]; other site 211586000417 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 211586000418 putative active site [active] 211586000419 Zn binding site [ion binding]; other site 211586000420 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 211586000421 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 211586000422 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 211586000423 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 211586000424 active site 211586000425 substrate-binding site [chemical binding]; other site 211586000426 metal-binding site [ion binding] 211586000427 ATP binding site [chemical binding]; other site 211586000428 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 211586000429 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 211586000430 dimerization interface [polypeptide binding]; other site 211586000431 domain crossover interface; other site 211586000432 redox-dependent activation switch; other site 211586000433 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211586000434 RNA binding surface [nucleotide binding]; other site 211586000435 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 211586000436 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 211586000437 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 211586000438 type II secretion system protein D; Region: type_II_gspD; TIGR02517 211586000439 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 211586000440 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 211586000441 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 211586000442 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 211586000443 type II secretion system protein E; Region: type_II_gspE; TIGR02533 211586000444 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 211586000445 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 211586000446 Walker A motif; other site 211586000447 ATP binding site [chemical binding]; other site 211586000448 Walker B motif; other site 211586000449 type II secretion system protein F; Region: GspF; TIGR02120 211586000450 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 211586000451 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 211586000452 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 211586000453 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 211586000454 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 211586000455 Type II secretion system (T2SS), protein J; Region: T2SJ; cl19722 211586000456 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 211586000457 Type II transport protein GspH; Region: GspH; pfam12019 211586000458 type II secretion system protein I; Region: gspI; TIGR01707 211586000459 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 211586000460 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 211586000461 type II secretion system protein J; Region: gspJ; TIGR01711 211586000462 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 211586000463 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 211586000464 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 211586000465 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 211586000466 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 211586000467 GspL periplasmic domain; Region: GspL_C; pfam12693 211586000468 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 211586000469 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 211586000470 GMP/IMP nucleotidase; Provisional; Region: PRK14988 211586000471 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 211586000472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211586000473 motif II; other site 211586000474 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 211586000475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586000476 S-adenosylmethionine binding site [chemical binding]; other site 211586000477 Protein of unknown function (DUF1611); Region: DUF1611; cl19508 211586000478 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 211586000479 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 211586000480 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 211586000481 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586000482 Coenzyme A binding pocket [chemical binding]; other site 211586000483 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 211586000484 Phage Tail Collar Domain; Region: Collar; pfam07484 211586000485 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 211586000486 Phage Tail Collar Domain; Region: Collar; pfam07484 211586000487 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 211586000488 Phage Tail Collar Domain; Region: Collar; pfam07484 211586000489 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 211586000490 Subtilase family; Region: Peptidase_S8; pfam00082 211586000491 active site 211586000492 catalytic residues [active] 211586000493 TIGR03032 family protein; Region: TIGR03032 211586000494 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 211586000495 Interdomain contacts; other site 211586000496 Cytokine receptor motif; other site 211586000497 BDLF3; Provisional; Region: PHA03255 211586000498 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 211586000499 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 211586000500 Interdomain contacts; other site 211586000501 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 211586000502 Interdomain contacts; other site 211586000503 Cytokine receptor motif; other site 211586000504 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 211586000505 Ca2+ binding site [ion binding]; other site 211586000506 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 211586000507 Ca2+ binding site [ion binding]; other site 211586000508 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 211586000509 Ca2+ binding site [ion binding]; other site 211586000510 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 211586000511 Ca2+ binding site [ion binding]; other site 211586000512 Calx-beta domain; Region: Calx-beta; cl02522 211586000513 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 211586000514 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 211586000515 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 211586000516 dimer interface [polypeptide binding]; other site 211586000517 ADP-ribose binding site [chemical binding]; other site 211586000518 active site 211586000519 nudix motif; other site 211586000520 metal binding site [ion binding]; metal-binding site 211586000521 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 211586000522 active site 211586000523 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 211586000524 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586000525 Coenzyme A binding pocket [chemical binding]; other site 211586000526 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 211586000527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211586000528 WHG domain; Region: WHG; pfam13305 211586000529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586000530 putative substrate translocation pore; other site 211586000531 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 211586000532 putative acyl-acceptor binding pocket; other site 211586000533 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 211586000534 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 211586000535 active site residue [active] 211586000536 selenophosphate synthetase; Provisional; Region: PRK00943 211586000537 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 211586000538 dimerization interface [polypeptide binding]; other site 211586000539 putative ATP binding site [chemical binding]; other site 211586000540 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 211586000541 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 211586000542 Di-iron ligands [ion binding]; other site 211586000543 putative di-iron ligands [ion binding]; other site 211586000544 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 211586000545 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211586000546 ThiC family; Region: ThiC; cl08031 211586000547 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 211586000548 BON domain; Region: BON; pfam04972 211586000549 BON domain; Region: BON; pfam04972 211586000550 BON domain; Region: BON; pfam04972 211586000551 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 211586000552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586000553 S-adenosylmethionine binding site [chemical binding]; other site 211586000554 glutamate racemase; Provisional; Region: PRK00865 211586000555 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 211586000556 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 211586000557 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 211586000558 FAD binding domain; Region: FAD_binding_4; pfam01565 211586000559 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 211586000560 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 211586000561 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 211586000562 dimerization interface [polypeptide binding]; other site 211586000563 putative Zn2+ binding site [ion binding]; other site 211586000564 putative DNA binding site [nucleotide binding]; other site 211586000565 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 211586000566 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 211586000567 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 211586000568 ATP-binding site [chemical binding]; other site 211586000569 CoA-binding site [chemical binding]; other site 211586000570 Mg2+-binding site [ion binding]; other site 211586000571 elongation factor Tu; Reviewed; Region: PRK00049 211586000572 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 211586000573 G1 box; other site 211586000574 GEF interaction site [polypeptide binding]; other site 211586000575 GTP/Mg2+ binding site [chemical binding]; other site 211586000576 Switch I region; other site 211586000577 G2 box; other site 211586000578 G3 box; other site 211586000579 Switch II region; other site 211586000580 G4 box; other site 211586000581 G5 box; other site 211586000582 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 211586000583 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 211586000584 Antibiotic Binding Site [chemical binding]; other site 211586000585 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 211586000586 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 211586000587 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 211586000588 putative homodimer interface [polypeptide binding]; other site 211586000589 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 211586000590 heterodimer interface [polypeptide binding]; other site 211586000591 homodimer interface [polypeptide binding]; other site 211586000592 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 211586000593 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 211586000594 23S rRNA interface [nucleotide binding]; other site 211586000595 L7/L12 interface [polypeptide binding]; other site 211586000596 putative thiostrepton binding site; other site 211586000597 L25 interface [polypeptide binding]; other site 211586000598 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 211586000599 mRNA/rRNA interface [nucleotide binding]; other site 211586000600 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 211586000601 23S rRNA interface [nucleotide binding]; other site 211586000602 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 211586000603 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 211586000604 core dimer interface [polypeptide binding]; other site 211586000605 peripheral dimer interface [polypeptide binding]; other site 211586000606 L10 interface [polypeptide binding]; other site 211586000607 L11 interface [polypeptide binding]; other site 211586000608 putative EF-Tu interaction site [polypeptide binding]; other site 211586000609 putative EF-G interaction site [polypeptide binding]; other site 211586000610 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 211586000611 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 211586000612 RPB12 interaction site [polypeptide binding]; other site 211586000613 RPB1 interaction site [polypeptide binding]; other site 211586000614 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 211586000615 RPB10 interaction site [polypeptide binding]; other site 211586000616 RPB11 interaction site [polypeptide binding]; other site 211586000617 RPB3 interaction site [polypeptide binding]; other site 211586000618 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 211586000619 beta and beta' interface [polypeptide binding]; other site 211586000620 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 211586000621 beta' and sigma factor interface [polypeptide binding]; other site 211586000622 Zn-binding [ion binding]; other site 211586000623 active site region [active] 211586000624 catalytic site [active] 211586000625 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 211586000626 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 211586000627 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 211586000628 G-loop; other site 211586000629 DNA binding site [nucleotide binding] 211586000630 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 211586000631 S17 interaction site [polypeptide binding]; other site 211586000632 S8 interaction site; other site 211586000633 16S rRNA interaction site [nucleotide binding]; other site 211586000634 streptomycin interaction site [chemical binding]; other site 211586000635 23S rRNA interaction site [nucleotide binding]; other site 211586000636 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 211586000637 30S ribosomal protein S7; Validated; Region: PRK05302 211586000638 elongation factor G; Reviewed; Region: PRK00007 211586000639 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 211586000640 G1 box; other site 211586000641 putative GEF interaction site [polypeptide binding]; other site 211586000642 GTP/Mg2+ binding site [chemical binding]; other site 211586000643 Switch I region; other site 211586000644 G2 box; other site 211586000645 G3 box; other site 211586000646 Switch II region; other site 211586000647 G4 box; other site 211586000648 G5 box; other site 211586000649 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 211586000650 Elongation Factor G, domain II; Region: EFG_II; pfam14492 211586000651 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 211586000652 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 211586000653 elongation factor Tu; Reviewed; Region: PRK00049 211586000654 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 211586000655 G1 box; other site 211586000656 GEF interaction site [polypeptide binding]; other site 211586000657 GTP/Mg2+ binding site [chemical binding]; other site 211586000658 Switch I region; other site 211586000659 G2 box; other site 211586000660 G3 box; other site 211586000661 Switch II region; other site 211586000662 G4 box; other site 211586000663 G5 box; other site 211586000664 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 211586000665 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 211586000666 Antibiotic Binding Site [chemical binding]; other site 211586000667 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 211586000668 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 211586000669 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 211586000670 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 211586000671 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 211586000672 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 211586000673 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 211586000674 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 211586000675 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 211586000676 putative translocon binding site; other site 211586000677 protein-rRNA interface [nucleotide binding]; other site 211586000678 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 211586000679 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 211586000680 G-X-X-G motif; other site 211586000681 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 211586000682 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 211586000683 23S rRNA interface [nucleotide binding]; other site 211586000684 5S rRNA interface [nucleotide binding]; other site 211586000685 putative antibiotic binding site [chemical binding]; other site 211586000686 L25 interface [polypeptide binding]; other site 211586000687 L27 interface [polypeptide binding]; other site 211586000688 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 211586000689 23S rRNA interface [nucleotide binding]; other site 211586000690 putative translocon interaction site; other site 211586000691 signal recognition particle (SRP54) interaction site; other site 211586000692 L23 interface [polypeptide binding]; other site 211586000693 trigger factor interaction site; other site 211586000694 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 211586000695 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 211586000696 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 211586000697 RNA binding site [nucleotide binding]; other site 211586000698 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 211586000699 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 211586000700 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 211586000701 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 211586000702 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 211586000703 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 211586000704 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 211586000705 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 211586000706 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 211586000707 23S rRNA interface [nucleotide binding]; other site 211586000708 L21e interface [polypeptide binding]; other site 211586000709 5S rRNA interface [nucleotide binding]; other site 211586000710 L27 interface [polypeptide binding]; other site 211586000711 L5 interface [polypeptide binding]; other site 211586000712 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 211586000713 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 211586000714 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 211586000715 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 211586000716 23S rRNA binding site [nucleotide binding]; other site 211586000717 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 211586000718 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 211586000719 SecY translocase; Region: SecY; pfam00344 211586000720 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 211586000721 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 211586000722 30S ribosomal protein S11; Validated; Region: PRK05309 211586000723 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 211586000724 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 211586000725 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211586000726 RNA binding surface [nucleotide binding]; other site 211586000727 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 211586000728 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 211586000729 alphaNTD homodimer interface [polypeptide binding]; other site 211586000730 alphaNTD - beta interaction site [polypeptide binding]; other site 211586000731 alphaNTD - beta' interaction site [polypeptide binding]; other site 211586000732 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 211586000733 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 211586000734 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 211586000735 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 211586000736 heme exporter protein CcmC; Region: ccmC; TIGR01191 211586000737 heme exporter protein CcmB; Region: ccmB; TIGR01190 211586000738 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 211586000739 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 211586000740 Walker A/P-loop; other site 211586000741 ATP binding site [chemical binding]; other site 211586000742 Q-loop/lid; other site 211586000743 ABC transporter signature motif; other site 211586000744 Walker B; other site 211586000745 D-loop; other site 211586000746 H-loop/switch region; other site 211586000747 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 211586000748 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 211586000749 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 211586000750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586000751 binding surface 211586000752 TPR motif; other site 211586000753 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 211586000754 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 211586000755 catalytic residues [active] 211586000756 central insert; other site 211586000757 Cytochrome C biogenesis protein; Region: CcmH; cl01179 211586000758 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 211586000759 catalytic residues [active] 211586000760 competence damage-inducible protein A; Provisional; Region: PRK00549 211586000761 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 211586000762 putative MPT binding site; other site 211586000763 Competence-damaged protein; Region: CinA; pfam02464 211586000764 Protein of unknown function (DUF1439); Region: DUF1439; pfam07273 211586000765 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 211586000766 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 211586000767 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 211586000768 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 211586000769 acetylglutamate kinase; Provisional; Region: PRK00942 211586000770 nucleotide binding site [chemical binding]; other site 211586000771 substrate binding site [chemical binding]; other site 211586000772 ornithine carbamoyltransferase; Provisional; Region: PRK14805 211586000773 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 211586000774 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 211586000775 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 211586000776 ANP binding site [chemical binding]; other site 211586000777 Substrate Binding Site II [chemical binding]; other site 211586000778 Substrate Binding Site I [chemical binding]; other site 211586000779 argininosuccinate lyase; Provisional; Region: PRK04833 211586000780 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 211586000781 active sites [active] 211586000782 tetramer interface [polypeptide binding]; other site 211586000783 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 211586000784 Transglycosylase; Region: Transgly; pfam00912 211586000785 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 211586000786 Cell division protein FtsA; Region: FtsA; cl17206 211586000787 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 211586000788 Type IV pilus assembly protein PilM; Region: PilM_2; pfam11104 211586000789 nucleotide binding site [chemical binding]; other site 211586000790 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 211586000791 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 211586000792 Pilus assembly protein, PilO; Region: PilO; pfam04350 211586000793 Pilus assembly protein, PilP; Region: PilP; pfam04351 211586000794 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 211586000795 Secretin and TonB N terminus short domain; Region: STN; smart00965 211586000796 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 211586000797 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 211586000798 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 211586000799 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 211586000800 ADP binding site [chemical binding]; other site 211586000801 magnesium binding site [ion binding]; other site 211586000802 putative shikimate binding site; other site 211586000803 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 211586000804 active site 211586000805 dimer interface [polypeptide binding]; other site 211586000806 metal binding site [ion binding]; metal-binding site 211586000807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586000808 Walker A motif; other site 211586000809 ATP binding site [chemical binding]; other site 211586000810 Walker B motif; other site 211586000811 Sporulation related domain; Region: SPOR; pfam05036 211586000812 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 211586000813 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 211586000814 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 211586000815 substrate binding site [chemical binding]; other site 211586000816 hexamer interface [polypeptide binding]; other site 211586000817 metal binding site [ion binding]; metal-binding site 211586000818 phosphoglycolate phosphatase; Provisional; Region: PRK13222 211586000819 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211586000820 active site 211586000821 motif I; other site 211586000822 motif II; other site 211586000823 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 211586000824 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 211586000825 active site 211586000826 HIGH motif; other site 211586000827 dimer interface [polypeptide binding]; other site 211586000828 KMSKS motif; other site 211586000829 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 211586000830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586000831 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 211586000832 dimerization interface [polypeptide binding]; other site 211586000833 substrate binding pocket [chemical binding]; other site 211586000834 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 211586000835 EamA-like transporter family; Region: EamA; pfam00892 211586000836 outer membrane lipoprotein; Provisional; Region: PRK11023 211586000837 BON domain; Region: BON; pfam04972 211586000838 BON domain; Region: BON; pfam04972 211586000839 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 211586000840 dimer interface [polypeptide binding]; other site 211586000841 active site 211586000842 hypothetical protein; Reviewed; Region: PRK12497 211586000843 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 211586000844 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 211586000845 putative ligand binding site [chemical binding]; other site 211586000846 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 211586000847 putative SAM binding site [chemical binding]; other site 211586000848 putative homodimer interface [polypeptide binding]; other site 211586000849 Restriction endonuclease; Region: Mrr_cat; pfam04471 211586000850 Restriction endonuclease; Region: Mrr_cat; pfam04471 211586000851 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 211586000852 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 211586000853 Uncharacterized conserved protein [Function unknown]; Region: COG2966 211586000854 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 211586000855 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 211586000856 MAPEG family; Region: MAPEG; cl09190 211586000857 hypothetical protein; Provisional; Region: PRK01254 211586000858 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 211586000859 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 211586000860 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 211586000861 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 211586000862 trimer interface [polypeptide binding]; other site 211586000863 eyelet of channel; other site 211586000864 putrescine transporter; Provisional; Region: potE; PRK10655 211586000865 ornithine decarboxylase; Provisional; Region: PRK13578 211586000866 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 211586000867 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 211586000868 homodimer interface [polypeptide binding]; other site 211586000869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586000870 catalytic residue [active] 211586000871 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 211586000872 Protein of unknown function (DUF2618); Region: DUF2618; pfam10940 211586000873 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 211586000874 substrate binding site [chemical binding]; other site 211586000875 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 211586000876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 211586000877 Uncharacterized conserved protein [Function unknown]; Region: COG3339 211586000878 Acyltransferase family; Region: Acyl_transf_3; pfam01757 211586000879 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 211586000880 putative amphipathic alpha helix; other site 211586000881 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 211586000882 DsrE/DsrF-like family; Region: DrsE; cl00672 211586000883 Transcription factor Opi1; Region: Opi1; pfam08618 211586000884 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586000885 binding surface 211586000886 TPR motif; other site 211586000887 hypothetical protein; Validated; Region: PRK00029 211586000888 Protein of unknown function (DUF3630); Region: DUF3630; pfam12305 211586000889 serine/threonine protein kinase; Provisional; Region: PRK11768 211586000890 Phosphotransferase enzyme family; Region: APH; pfam01636 211586000891 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 211586000892 catalytic residues [active] 211586000893 hinge region; other site 211586000894 alpha helical domain; other site 211586000895 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 211586000896 Protein of unknown function (DUF904); Region: DUF904; pfam06005 211586000897 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 211586000898 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 211586000899 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 211586000900 homotrimer interaction site [polypeptide binding]; other site 211586000901 putative active site [active] 211586000902 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; pfam07073 211586000903 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 211586000904 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 211586000905 homodimer interface [polypeptide binding]; other site 211586000906 substrate-cofactor binding pocket; other site 211586000907 catalytic residue [active] 211586000908 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 211586000909 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 211586000910 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586000911 putative active site [active] 211586000912 heme pocket [chemical binding]; other site 211586000913 PAS fold; Region: PAS_3; pfam08447 211586000914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586000915 PAS domain; Region: PAS_9; pfam13426 211586000916 putative active site [active] 211586000917 heme pocket [chemical binding]; other site 211586000918 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586000919 metal binding site [ion binding]; metal-binding site 211586000920 active site 211586000921 I-site; other site 211586000922 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586000923 PrpF protein; Region: PrpF; cl19418 211586000924 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 211586000925 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 211586000926 substrate binding site [chemical binding]; other site 211586000927 ligand binding site [chemical binding]; other site 211586000928 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 211586000929 substrate binding site [chemical binding]; other site 211586000930 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 211586000931 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 211586000932 dimer interface [polypeptide binding]; other site 211586000933 active site 211586000934 citrylCoA binding site [chemical binding]; other site 211586000935 oxalacetate/citrate binding site [chemical binding]; other site 211586000936 coenzyme A binding site [chemical binding]; other site 211586000937 catalytic triad [active] 211586000938 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 211586000939 tetramer interface [polypeptide binding]; other site 211586000940 active site 211586000941 Mg2+/Mn2+ binding site [ion binding]; other site 211586000942 Transcriptional regulators [Transcription]; Region: GntR; COG1802 211586000943 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 211586000944 DNA-binding site [nucleotide binding]; DNA binding site 211586000945 FCD domain; Region: FCD; pfam07729 211586000946 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 211586000947 putative acyl-acceptor binding pocket; other site 211586000948 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 211586000949 putative acyl-acceptor binding pocket; other site 211586000950 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 211586000951 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 211586000952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586000953 Walker A motif; other site 211586000954 ATP binding site [chemical binding]; other site 211586000955 Walker B motif; other site 211586000956 arginine finger; other site 211586000957 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 211586000958 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 211586000959 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 211586000960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586000961 active site 211586000962 phosphorylation site [posttranslational modification] 211586000963 intermolecular recognition site; other site 211586000964 dimerization interface [polypeptide binding]; other site 211586000965 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 211586000966 DNA binding residues [nucleotide binding] 211586000967 dimerization interface [polypeptide binding]; other site 211586000968 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 211586000969 Histidine kinase; Region: HisKA_3; pfam07730 211586000970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586000971 ATP binding site [chemical binding]; other site 211586000972 Mg2+ binding site [ion binding]; other site 211586000973 Tetratricopeptide repeat; Region: TPR_1; pfam00515 211586000974 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 211586000975 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 211586000976 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 211586000977 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 211586000978 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 211586000979 acyl-activating enzyme (AAE) consensus motif; other site 211586000980 putative AMP binding site [chemical binding]; other site 211586000981 putative active site [active] 211586000982 putative CoA binding site [chemical binding]; other site 211586000983 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586000984 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586000985 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 211586000986 homotrimer interaction site [polypeptide binding]; other site 211586000987 putative active site [active] 211586000988 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 211586000989 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211586000990 Zn2+ binding site [ion binding]; other site 211586000991 Mg2+ binding site [ion binding]; other site 211586000992 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 211586000993 synthetase active site [active] 211586000994 NTP binding site [chemical binding]; other site 211586000995 metal binding site [ion binding]; metal-binding site 211586000996 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 211586000997 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 211586000998 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 211586000999 Guanylate kinase; Region: Guanylate_kin; pfam00625 211586001000 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 211586001001 catalytic site [active] 211586001002 G-X2-G-X-G-K; other site 211586001003 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 211586001004 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 211586001005 active site 211586001006 Phosphotransferase enzyme family; Region: APH; pfam01636 211586001007 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 211586001008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586001009 putative substrate translocation pore; other site 211586001010 Major Facilitator Superfamily; Region: MFS_1; pfam07690 211586001011 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 211586001012 Fic family protein [Function unknown]; Region: COG3177 211586001013 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 211586001014 Fic/DOC family; Region: Fic; pfam02661 211586001015 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 211586001016 putative DNA binding helix; other site 211586001017 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 211586001018 PLD-like domain; Region: PLDc_2; pfam13091 211586001019 putative homodimer interface [polypeptide binding]; other site 211586001020 putative active site [active] 211586001021 catalytic site [active] 211586001022 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 211586001023 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211586001024 ATP binding site [chemical binding]; other site 211586001025 putative Mg++ binding site [ion binding]; other site 211586001026 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586001027 nucleotide binding region [chemical binding]; other site 211586001028 ATP-binding site [chemical binding]; other site 211586001029 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 211586001030 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586001031 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586001032 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 211586001033 putative effector binding pocket; other site 211586001034 dimerization interface [polypeptide binding]; other site 211586001035 Protein of unknown function, DUF606; Region: DUF606; pfam04657 211586001036 Protein of unknown function, DUF606; Region: DUF606; pfam04657 211586001037 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 211586001038 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211586001039 motif II; other site 211586001040 Transposase; Region: HTH_Tnp_1; pfam01527 211586001041 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586001042 putative transposase OrfB; Reviewed; Region: PHA02517 211586001043 HTH-like domain; Region: HTH_21; pfam13276 211586001044 Integrase core domain; Region: rve; pfam00665 211586001045 Integrase core domain; Region: rve_2; pfam13333 211586001046 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586001047 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586001048 Protein of unknown function DUF45; Region: DUF45; pfam01863 211586001049 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 211586001050 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 211586001051 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211586001052 ATP binding site [chemical binding]; other site 211586001053 putative Mg++ binding site [ion binding]; other site 211586001054 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 211586001055 Virulence protein RhuM family; Region: Virulence_RhuM; cl19850 211586001056 Fic/DOC family; Region: Fic; pfam02661 211586001057 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 211586001058 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 211586001059 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 211586001060 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 211586001061 HsdM N-terminal domain; Region: HsdM_N; pfam12161 211586001062 Methyltransferase domain; Region: Methyltransf_26; pfam13659 211586001063 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 211586001064 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 211586001065 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 211586001066 integrase; Provisional; Region: PRK09692 211586001067 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 211586001068 active site 211586001069 Int/Topo IB signature motif; other site 211586001070 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 211586001071 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 211586001072 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 211586001073 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 211586001074 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 211586001075 FMN binding site [chemical binding]; other site 211586001076 active site 211586001077 catalytic residues [active] 211586001078 substrate binding site [chemical binding]; other site 211586001079 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 211586001080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586001081 S-adenosylmethionine binding site [chemical binding]; other site 211586001082 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13554 211586001083 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 211586001084 Iron-sulfur protein interface; other site 211586001085 proximal heme binding site [chemical binding]; other site 211586001086 distal heme binding site [chemical binding]; other site 211586001087 dimer interface [polypeptide binding]; other site 211586001088 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 211586001089 Iron-sulfur protein interface; other site 211586001090 proximal heme binding site [chemical binding]; other site 211586001091 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 211586001092 L-aspartate oxidase; Provisional; Region: PRK06175 211586001093 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 211586001094 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 211586001095 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 211586001096 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 211586001097 Uncharacterized conserved protein [Function unknown]; Region: COG1359 211586001098 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 211586001099 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 211586001100 putative NAD(P) binding site [chemical binding]; other site 211586001101 dimer interface [polypeptide binding]; other site 211586001102 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586001103 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586001104 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 211586001105 putative effector binding pocket; other site 211586001106 dimerization interface [polypeptide binding]; other site 211586001107 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 211586001108 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 211586001109 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 211586001110 active site 211586001111 active site 211586001112 transcription termination factor Rho; Provisional; Region: rho; PRK09376 211586001113 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 211586001114 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 211586001115 RNA binding site [nucleotide binding]; other site 211586001116 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 211586001117 multimer interface [polypeptide binding]; other site 211586001118 Walker A motif; other site 211586001119 ATP binding site [chemical binding]; other site 211586001120 Walker B motif; other site 211586001121 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 211586001122 catalytic residues [active] 211586001123 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 211586001124 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 211586001125 ATP binding site [chemical binding]; other site 211586001126 Mg++ binding site [ion binding]; other site 211586001127 motif III; other site 211586001128 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586001129 nucleotide binding region [chemical binding]; other site 211586001130 ATP-binding site [chemical binding]; other site 211586001131 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 211586001132 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 211586001133 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 211586001134 catalytic residues [active] 211586001135 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 211586001136 active site 211586001137 8-oxo-dGMP binding site [chemical binding]; other site 211586001138 nudix motif; other site 211586001139 metal binding site [ion binding]; metal-binding site 211586001140 Domain of unknown function (DUF329); Region: DUF329; pfam03884 211586001141 hypothetical protein; Provisional; Region: PRK05287 211586001142 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 211586001143 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 211586001144 CoA-binding site [chemical binding]; other site 211586001145 ATP-binding [chemical binding]; other site 211586001146 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 211586001147 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 211586001148 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 211586001149 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 211586001150 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 211586001151 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 211586001152 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 211586001153 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 211586001154 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 211586001155 Walker A motif; other site 211586001156 ATP binding site [chemical binding]; other site 211586001157 Walker B motif; other site 211586001158 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 211586001159 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 211586001160 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 211586001161 dimerization interface [polypeptide binding]; other site 211586001162 active site 211586001163 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 211586001164 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 211586001165 amidase catalytic site [active] 211586001166 Zn binding residues [ion binding]; other site 211586001167 substrate binding site [chemical binding]; other site 211586001168 regulatory protein AmpE; Provisional; Region: PRK10987 211586001169 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 211586001170 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 211586001171 DNA-binding site [nucleotide binding]; DNA binding site 211586001172 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 211586001173 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 211586001174 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 211586001175 dimer interface [polypeptide binding]; other site 211586001176 TPP-binding site [chemical binding]; other site 211586001177 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 211586001178 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 211586001179 E3 interaction surface; other site 211586001180 lipoyl attachment site [posttranslational modification]; other site 211586001181 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 211586001182 E3 interaction surface; other site 211586001183 lipoyl attachment site [posttranslational modification]; other site 211586001184 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 211586001185 E3 interaction surface; other site 211586001186 lipoyl attachment site [posttranslational modification]; other site 211586001187 e3 binding domain; Region: E3_binding; pfam02817 211586001188 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 211586001189 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 211586001190 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 211586001191 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 211586001192 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 211586001193 Protein of unknown function (DUF3316); Region: DUF3316; pfam11777 211586001194 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 211586001195 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 211586001196 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586001197 heme pocket [chemical binding]; other site 211586001198 putative active site [active] 211586001199 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586001200 putative active site [active] 211586001201 heme pocket [chemical binding]; other site 211586001202 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586001203 metal binding site [ion binding]; metal-binding site 211586001204 active site 211586001205 I-site; other site 211586001206 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586001207 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 211586001208 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 211586001209 active site 211586001210 nucleophile elbow; other site 211586001211 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 211586001212 Surface antigen; Region: Bac_surface_Ag; pfam01103 211586001213 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 211586001214 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 211586001215 active site 211586001216 Zn binding site [ion binding]; other site 211586001217 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 211586001218 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 211586001219 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211586001220 active site 211586001221 motif I; other site 211586001222 motif II; other site 211586001223 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 211586001224 Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791 211586001225 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 211586001226 substrate binding site [chemical binding]; other site 211586001227 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 211586001228 substrate binding site [chemical binding]; other site 211586001229 ligand binding site [chemical binding]; other site 211586001230 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 211586001231 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 211586001232 substrate binding site [chemical binding]; other site 211586001233 active site 211586001234 PAS fold; Region: PAS_4; pfam08448 211586001235 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586001236 putative active site [active] 211586001237 heme pocket [chemical binding]; other site 211586001238 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586001239 metal binding site [ion binding]; metal-binding site 211586001240 active site 211586001241 I-site; other site 211586001242 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586001243 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 211586001244 short chain dehydrogenase; Provisional; Region: PRK06181 211586001245 NADP binding site [chemical binding]; other site 211586001246 homodimer interface [polypeptide binding]; other site 211586001247 substrate binding site [chemical binding]; other site 211586001248 active site 211586001249 Peptidase M60-like family; Region: M60-like; cl19940 211586001250 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 211586001251 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 211586001252 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 211586001253 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 211586001254 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 211586001255 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 211586001256 purine monophosphate binding site [chemical binding]; other site 211586001257 dimer interface [polypeptide binding]; other site 211586001258 putative catalytic residues [active] 211586001259 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 211586001260 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 211586001261 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 211586001262 DNA binding residues [nucleotide binding] 211586001263 dimer interface [polypeptide binding]; other site 211586001264 metal binding site [ion binding]; metal-binding site 211586001265 Predicted permease; Region: DUF318; cl17795 211586001266 Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_prohibitin; cd03401 211586001267 prohibitin homologues; Region: PHB; smart00244 211586001268 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 211586001269 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 211586001270 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 211586001271 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 211586001272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586001273 Major Facilitator Superfamily; Region: MFS_1; pfam07690 211586001274 putative substrate translocation pore; other site 211586001275 thioredoxin 2; Provisional; Region: PRK10996 211586001276 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 211586001277 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 211586001278 catalytic residues [active] 211586001279 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 211586001280 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 211586001281 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 211586001282 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 211586001283 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 211586001284 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 211586001285 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 211586001286 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 211586001287 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 211586001288 Predicted metalloprotease [General function prediction only]; Region: COG2321 211586001289 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 211586001290 nudix motif; other site 211586001291 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; cl08066 211586001292 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 211586001293 Part of AAA domain; Region: AAA_19; pfam13245 211586001294 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 211586001295 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 211586001296 putative active site [active] 211586001297 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 211586001298 Protein of unknown function (DUF2541); Region: DUF2541; cl08090 211586001299 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 211586001300 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 211586001301 FMN binding site [chemical binding]; other site 211586001302 substrate binding site [chemical binding]; other site 211586001303 putative catalytic residue [active] 211586001304 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 211586001305 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 211586001306 metal binding site [ion binding]; metal-binding site 211586001307 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 211586001308 catalytic residues [active] 211586001309 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 211586001310 cytochrome c nitrate reductase biogenesis protein NrfE; Region: cyt_nit_nrfE; TIGR03145 211586001311 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 211586001312 Cytochrome c7; Region: Cytochrome_C7; pfam14522 211586001313 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 211586001314 active site residue [active] 211586001315 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 211586001316 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 211586001317 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 211586001318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586001319 TPR motif; other site 211586001320 TPR repeat; Region: TPR_11; pfam13414 211586001321 binding surface 211586001322 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 211586001323 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 211586001324 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 211586001325 NosL; Region: NosL; pfam05573 211586001326 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 211586001327 Domain present in carbohydrate binding proteins and sugar hydrolses; Region: CASH; smart00722 211586001328 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 211586001329 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 211586001330 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 211586001331 Walker A/P-loop; other site 211586001332 ATP binding site [chemical binding]; other site 211586001333 Q-loop/lid; other site 211586001334 ABC transporter signature motif; other site 211586001335 Walker B; other site 211586001336 D-loop; other site 211586001337 H-loop/switch region; other site 211586001338 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 211586001339 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 211586001340 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211586001341 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 211586001342 DNA binding site [nucleotide binding] 211586001343 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 211586001344 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 211586001345 active site 211586001346 Zn binding site [ion binding]; other site 211586001347 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 211586001348 Transposase; Region: HTH_Tnp_1; pfam01527 211586001349 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586001350 putative transposase OrfB; Reviewed; Region: PHA02517 211586001351 HTH-like domain; Region: HTH_21; pfam13276 211586001352 Integrase core domain; Region: rve; pfam00665 211586001353 Integrase core domain; Region: rve_2; pfam13333 211586001354 ATP-grasp domain; Region: ATP-grasp_4; cl17255 211586001355 ATP-grasp ribosomal peptide maturase, MvdC family; Region: ATPgraspMvdC; TIGR04185 211586001356 Nuclease-related domain; Region: NERD; pfam08378 211586001357 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 211586001358 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 211586001359 active site 211586001360 ATP binding site [chemical binding]; other site 211586001361 substrate binding site [chemical binding]; other site 211586001362 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 211586001363 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 211586001364 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586001365 dimerization interface [polypeptide binding]; other site 211586001366 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 211586001367 dimer interface [polypeptide binding]; other site 211586001368 putative CheW interface [polypeptide binding]; other site 211586001369 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 211586001370 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 211586001371 dimerization interface [polypeptide binding]; other site 211586001372 putative DNA binding site [nucleotide binding]; other site 211586001373 putative Zn2+ binding site [ion binding]; other site 211586001374 Predicted permeases [General function prediction only]; Region: COG0701 211586001375 FMN reductase; Validated; Region: fre; PRK08051 211586001376 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 211586001377 FAD binding pocket [chemical binding]; other site 211586001378 FAD binding motif [chemical binding]; other site 211586001379 phosphate binding motif [ion binding]; other site 211586001380 beta-alpha-beta structure motif; other site 211586001381 NAD binding pocket [chemical binding]; other site 211586001382 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 211586001383 Sel1 repeat; Region: Sel1; pfam08238 211586001384 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 211586001385 short chain dehydrogenase; Provisional; Region: PRK07454 211586001386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 211586001387 NAD(P) binding site [chemical binding]; other site 211586001388 active site 211586001389 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 211586001390 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 211586001391 carboxyltransferase (CT) interaction site; other site 211586001392 biotinylation site [posttranslational modification]; other site 211586001393 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 211586001394 trimer interface [polypeptide binding]; other site 211586001395 active site 211586001396 dimer interface [polypeptide binding]; other site 211586001397 hypothetical protein; Provisional; Region: PRK09256 211586001398 SpoIIAA-like; Region: SpoIIAA-like; pfam11964 211586001399 Protein of unknown function (DUF3012); Region: DUF3012; pfam11216 211586001400 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 211586001401 Outer membrane efflux protein; Region: OEP; pfam02321 211586001402 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 211586001403 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 211586001404 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586001405 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 211586001406 MMPL family; Region: MMPL; cl14618 211586001407 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 211586001408 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 211586001409 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586001410 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586001411 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 211586001412 putative effector binding pocket; other site 211586001413 dimerization interface [polypeptide binding]; other site 211586001414 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 211586001415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586001416 putative substrate translocation pore; other site 211586001417 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 211586001418 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586001419 Coenzyme A binding pocket [chemical binding]; other site 211586001420 Uncharacterized conserved protein [Function unknown]; Region: COG1359 211586001421 Radical SAM superfamily; Region: Radical_SAM; pfam04055 211586001422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211586001423 FeS/SAM binding site; other site 211586001424 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 211586001425 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586001426 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 211586001427 dimerization interface [polypeptide binding]; other site 211586001428 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 211586001429 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 211586001430 dimerization interface [polypeptide binding]; other site 211586001431 putative DNA binding site [nucleotide binding]; other site 211586001432 putative Zn2+ binding site [ion binding]; other site 211586001433 Low molecular weight phosphatase family; Region: LMWPc; cd00115 211586001434 active site 211586001435 arsenical-resistance protein; Region: acr3; TIGR00832 211586001436 Predicted permeases [General function prediction only]; Region: COG0701 211586001437 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 211586001438 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 211586001439 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 211586001440 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 211586001441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586001442 putative substrate translocation pore; other site 211586001443 Major Facilitator Superfamily; Region: MFS_1; pfam07690 211586001444 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 211586001445 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 211586001446 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 211586001447 Beta-Casp domain; Region: Beta-Casp; smart01027 211586001448 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 211586001449 conserved hypothetical protein; Region: QEGLA; TIGR02421 211586001450 CHASE domain; Region: CHASE; pfam03924 211586001451 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 211586001452 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586001453 putative active site [active] 211586001454 heme pocket [chemical binding]; other site 211586001455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586001456 dimer interface [polypeptide binding]; other site 211586001457 phosphorylation site [posttranslational modification] 211586001458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586001459 ATP binding site [chemical binding]; other site 211586001460 Mg2+ binding site [ion binding]; other site 211586001461 G-X-G motif; other site 211586001462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586001463 active site 211586001464 phosphorylation site [posttranslational modification] 211586001465 intermolecular recognition site; other site 211586001466 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 211586001467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586001468 active site 211586001469 phosphorylation site [posttranslational modification] 211586001470 intermolecular recognition site; other site 211586001471 dimerization interface [polypeptide binding]; other site 211586001472 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586001473 metal binding site [ion binding]; metal-binding site 211586001474 active site 211586001475 I-site; other site 211586001476 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586001477 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 211586001478 ATP-grasp domain; Region: ATP-grasp_4; cl17255 211586001479 conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001 211586001480 histone-like DNA-binding protein HU; Region: HU; cd13831 211586001481 dimer interface [polypeptide binding]; other site 211586001482 DNA binding site [nucleotide binding] 211586001483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586001484 active site 211586001485 phosphorylation site [posttranslational modification] 211586001486 intermolecular recognition site; other site 211586001487 dimerization interface [polypeptide binding]; other site 211586001488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586001489 active site 211586001490 phosphorylation site [posttranslational modification] 211586001491 intermolecular recognition site; other site 211586001492 dimerization interface [polypeptide binding]; other site 211586001493 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 211586001494 probable methionyl-tRNA synthetase; Region: PLN02610 211586001495 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 211586001496 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586001497 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 211586001498 FOG: CBS domain [General function prediction only]; Region: COG0517 211586001499 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586001500 metal binding site [ion binding]; metal-binding site 211586001501 active site 211586001502 I-site; other site 211586001503 TraB family; Region: TraB; pfam01963 211586001504 Methyltransferase domain; Region: Methyltransf_31; pfam13847 211586001505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586001506 S-adenosylmethionine binding site [chemical binding]; other site 211586001507 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 211586001508 active site 2 [active] 211586001509 active site 1 [active] 211586001510 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 211586001511 Potassium binding sites [ion binding]; other site 211586001512 Cesium cation binding sites [ion binding]; other site 211586001513 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 211586001514 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 211586001515 Periplasmic binding protein TroA_c. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_c; cd01145 211586001516 putative ligand binding site [chemical binding]; other site 211586001517 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 211586001518 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 211586001519 putative acyl-acceptor binding pocket; other site 211586001520 RNase E inhibitor protein; Provisional; Region: PRK11191 211586001521 PAS domain; Region: PAS_9; pfam13426 211586001522 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586001523 putative active site [active] 211586001524 heme pocket [chemical binding]; other site 211586001525 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586001526 metal binding site [ion binding]; metal-binding site 211586001527 active site 211586001528 I-site; other site 211586001529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586001530 active site 211586001531 phosphorylation site [posttranslational modification] 211586001532 intermolecular recognition site; other site 211586001533 dimerization interface [polypeptide binding]; other site 211586001534 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 211586001535 enoyl-CoA hydratase; Provisional; Region: PRK07509 211586001536 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 211586001537 substrate binding site [chemical binding]; other site 211586001538 oxyanion hole (OAH) forming residues; other site 211586001539 trimer interface [polypeptide binding]; other site 211586001540 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 211586001541 ATP-dependent helicase HepA; Validated; Region: PRK04914 211586001542 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211586001543 ATP binding site [chemical binding]; other site 211586001544 putative Mg++ binding site [ion binding]; other site 211586001545 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586001546 nucleotide binding region [chemical binding]; other site 211586001547 ATP-binding site [chemical binding]; other site 211586001548 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 211586001549 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 211586001550 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 211586001551 putative active site [active] 211586001552 PhoH-like protein; Region: PhoH; cl17668 211586001553 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 211586001554 active site 211586001555 Catalytic domain of Protein Kinases; Region: PKc; cd00180 211586001556 active site 211586001557 ATP binding site [chemical binding]; other site 211586001558 substrate binding site [chemical binding]; other site 211586001559 activation loop (A-loop); other site 211586001560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586001561 S-adenosylmethionine binding site [chemical binding]; other site 211586001562 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 211586001563 PAS domain; Region: PAS_9; pfam13426 211586001564 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586001565 putative active site [active] 211586001566 heme pocket [chemical binding]; other site 211586001567 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 211586001568 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 211586001569 dimer interface [polypeptide binding]; other site 211586001570 putative CheW interface [polypeptide binding]; other site 211586001571 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 211586001572 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 211586001573 NAD binding site [chemical binding]; other site 211586001574 ligand binding site [chemical binding]; other site 211586001575 catalytic site [active] 211586001576 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 211586001577 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 211586001578 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 211586001579 active site 211586001580 catalytic site [active] 211586001581 metal binding site [ion binding]; metal-binding site 211586001582 putative mechanosensitive channel protein; Provisional; Region: PRK10929 211586001583 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 211586001584 Mechanosensitive ion channel; Region: MS_channel; pfam00924 211586001585 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 211586001586 GTPase RsgA; Reviewed; Region: PRK12288 211586001587 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 211586001588 RNA binding site [nucleotide binding]; other site 211586001589 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 211586001590 GTPase/Zn-binding domain interface [polypeptide binding]; other site 211586001591 GTP/Mg2+ binding site [chemical binding]; other site 211586001592 G4 box; other site 211586001593 G5 box; other site 211586001594 G1 box; other site 211586001595 Switch I region; other site 211586001596 G2 box; other site 211586001597 G3 box; other site 211586001598 Switch II region; other site 211586001599 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 211586001600 catalytic site [active] 211586001601 putative active site [active] 211586001602 putative substrate binding site [chemical binding]; other site 211586001603 dimer interface [polypeptide binding]; other site 211586001604 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 211586001605 dinuclear metal binding motif [ion binding]; other site 211586001606 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586001607 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586001608 putative carbohydrate kinase; Provisional; Region: PRK10565 211586001609 Uncharacterized conserved protein [Function unknown]; Region: COG0062 211586001610 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 211586001611 putative substrate binding site [chemical binding]; other site 211586001612 putative ATP binding site [chemical binding]; other site 211586001613 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 211586001614 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 211586001615 AMIN domain; Region: AMIN; pfam11741 211586001616 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 211586001617 active site 211586001618 metal binding site [ion binding]; metal-binding site 211586001619 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 211586001620 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 211586001621 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 211586001622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586001623 ATP binding site [chemical binding]; other site 211586001624 Mg2+ binding site [ion binding]; other site 211586001625 G-X-G motif; other site 211586001626 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 211586001627 ATP binding site [chemical binding]; other site 211586001628 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 211586001629 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 211586001630 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 211586001631 active site 211586001632 bacterial Hfq-like; Region: Hfq; cd01716 211586001633 hexamer interface [polypeptide binding]; other site 211586001634 Sm1 motif; other site 211586001635 RNA binding site [nucleotide binding]; other site 211586001636 Sm2 motif; other site 211586001637 GTPase HflX; Provisional; Region: PRK11058 211586001638 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 211586001639 HflX GTPase family; Region: HflX; cd01878 211586001640 G1 box; other site 211586001641 GTP/Mg2+ binding site [chemical binding]; other site 211586001642 Switch I region; other site 211586001643 G2 box; other site 211586001644 G3 box; other site 211586001645 Switch II region; other site 211586001646 G4 box; other site 211586001647 G5 box; other site 211586001648 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 211586001649 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 211586001650 HflK protein; Region: hflK; TIGR01933 211586001651 HflC protein; Region: hflC; TIGR01932 211586001652 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 211586001653 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 211586001654 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 211586001655 [2Fe-2S] cluster binding site [ion binding]; other site 211586001656 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 211586001657 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 211586001658 Qi binding site; other site 211586001659 intrachain domain interface; other site 211586001660 interchain domain interface [polypeptide binding]; other site 211586001661 heme bH binding site [chemical binding]; other site 211586001662 heme bL binding site [chemical binding]; other site 211586001663 Qo binding site; other site 211586001664 interchain domain interface [polypeptide binding]; other site 211586001665 intrachain domain interface; other site 211586001666 Qi binding site; other site 211586001667 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 211586001668 Qo binding site; other site 211586001669 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 211586001670 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 211586001671 stringent starvation protein A; Provisional; Region: sspA; PRK09481 211586001672 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 211586001673 C-terminal domain interface [polypeptide binding]; other site 211586001674 putative GSH binding site (G-site) [chemical binding]; other site 211586001675 dimer interface [polypeptide binding]; other site 211586001676 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 211586001677 dimer interface [polypeptide binding]; other site 211586001678 N-terminal domain interface [polypeptide binding]; other site 211586001679 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 211586001680 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 211586001681 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 211586001682 glutamine binding [chemical binding]; other site 211586001683 catalytic triad [active] 211586001684 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 211586001685 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 211586001686 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 211586001687 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 211586001688 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 211586001689 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 211586001690 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 211586001691 inhibitor-cofactor binding pocket; inhibition site 211586001692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586001693 catalytic residue [active] 211586001694 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 211586001695 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 211586001696 NAD(P) binding site [chemical binding]; other site 211586001697 catalytic residues [active] 211586001698 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 211586001699 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211586001700 HAMP domain; Region: HAMP; pfam00672 211586001701 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586001702 dimer interface [polypeptide binding]; other site 211586001703 phosphorylation site [posttranslational modification] 211586001704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586001705 ATP binding site [chemical binding]; other site 211586001706 Mg2+ binding site [ion binding]; other site 211586001707 G-X-G motif; other site 211586001708 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211586001709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586001710 active site 211586001711 phosphorylation site [posttranslational modification] 211586001712 intermolecular recognition site; other site 211586001713 dimerization interface [polypeptide binding]; other site 211586001714 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211586001715 DNA binding site [nucleotide binding] 211586001716 Predicted membrane protein [Function unknown]; Region: COG3212 211586001717 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 211586001718 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 211586001719 ligand binding site [chemical binding]; other site 211586001720 flexible hinge region; other site 211586001721 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 211586001722 putative switch regulator; other site 211586001723 non-specific DNA interactions [nucleotide binding]; other site 211586001724 DNA binding site [nucleotide binding] 211586001725 sequence specific DNA binding site [nucleotide binding]; other site 211586001726 putative cAMP binding site [chemical binding]; other site 211586001727 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 211586001728 Sel1-like repeats; Region: SEL1; smart00671 211586001729 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586001730 binding surface 211586001731 TPR motif; other site 211586001732 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 211586001733 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 211586001734 GAF domain; Region: GAF; cl17456 211586001735 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586001736 metal binding site [ion binding]; metal-binding site 211586001737 active site 211586001738 I-site; other site 211586001739 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586001740 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 211586001741 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 211586001742 N-terminal plug; other site 211586001743 ligand-binding site [chemical binding]; other site 211586001744 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 211586001745 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211586001746 ATP binding site [chemical binding]; other site 211586001747 putative Mg++ binding site [ion binding]; other site 211586001748 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586001749 nucleotide binding region [chemical binding]; other site 211586001750 ATP-binding site [chemical binding]; other site 211586001751 Helicase associated domain (HA2); Region: HA2; pfam04408 211586001752 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 211586001753 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 211586001754 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 211586001755 Transglycosylase; Region: Transgly; pfam00912 211586001756 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 211586001757 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 211586001758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586001759 Coenzyme A binding pocket [chemical binding]; other site 211586001760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 211586001761 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 211586001762 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 211586001763 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 211586001764 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 211586001765 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 211586001766 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 211586001767 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 211586001768 NAD(P) binding site [chemical binding]; other site 211586001769 prophage MuSo1 211586001770 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211586001771 non-specific DNA binding site [nucleotide binding]; other site 211586001772 salt bridge; other site 211586001773 sequence-specific DNA binding site [nucleotide binding]; other site 211586001774 Predicted transcriptional regulator [Transcription]; Region: COG2932 211586001775 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 211586001776 Catalytic site [active] 211586001777 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 211586001778 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 211586001779 Winged helix-turn helix; Region: HTH_29; pfam13551 211586001780 Homeodomain-like domain; Region: HTH_32; pfam13565 211586001781 Integrase core domain; Region: rve; pfam00665 211586001782 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 211586001783 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 211586001784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586001785 Walker A motif; other site 211586001786 ATP binding site [chemical binding]; other site 211586001787 Walker B motif; other site 211586001788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211586001789 sequence-specific DNA binding site [nucleotide binding]; other site 211586001790 salt bridge; other site 211586001791 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 211586001792 Protein of unknown function (DUF1018); Region: DUF1018; pfam06252 211586001793 Mor transcription activator family; Region: Mor; pfam08765 211586001794 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 211586001795 Transposase; Region: HTH_Tnp_1; pfam01527 211586001796 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586001797 putative transposase OrfB; Reviewed; Region: PHA02517 211586001798 HTH-like domain; Region: HTH_21; pfam13276 211586001799 Integrase core domain; Region: rve; pfam00665 211586001800 Integrase core domain; Region: rve_2; pfam13333 211586001801 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 211586001802 catalytic residue [active] 211586001803 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 211586001804 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 211586001805 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805 211586001806 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 211586001807 Phage Terminase; Region: Terminase_1; cl19862 211586001808 Terminase-like family; Region: Terminase_6; pfam03237 211586001809 Protein of unknown function (DUF935); Region: DUF935; pfam06074 211586001810 Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369 211586001811 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 211586001812 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 211586001813 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 211586001814 Bacterial SH3 domain; Region: SH3_3; pfam08239 211586001815 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 211586001816 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; pfam10124 211586001817 Protein of unknown function (DUF1320); Region: DUF1320; pfam07030 211586001818 cell surface protein SprA; Region: surface_SprA; TIGR04189 211586001819 tape measure domain; Region: tape_meas_nterm; TIGR02675 211586001820 Transposase; Region: HTH_Tnp_1; pfam01527 211586001821 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586001822 putative transposase OrfB; Reviewed; Region: PHA02517 211586001823 HTH-like domain; Region: HTH_21; pfam13276 211586001824 Integrase core domain; Region: rve; pfam00665 211586001825 Integrase core domain; Region: rve_2; pfam13333 211586001826 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 211586001827 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 211586001828 active site 211586001829 catalytic residues [active] 211586001830 galactokinase; Provisional; Region: PRK05101 211586001831 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 211586001832 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 211586001833 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 211586001834 TrkA-N domain; Region: TrkA_N; pfam02254 211586001835 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 211586001836 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 211586001837 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 211586001838 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 211586001839 DsbD alpha interface [polypeptide binding]; other site 211586001840 catalytic residues [active] 211586001841 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 211586001842 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 211586001843 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586001844 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586001845 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 211586001846 putative effector binding pocket; other site 211586001847 dimerization interface [polypeptide binding]; other site 211586001848 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 211586001849 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 211586001850 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 211586001851 oligomerisation interface [polypeptide binding]; other site 211586001852 mobile loop; other site 211586001853 roof hairpin; other site 211586001854 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 211586001855 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 211586001856 ring oligomerisation interface [polypeptide binding]; other site 211586001857 ATP/Mg binding site [chemical binding]; other site 211586001858 stacking interactions; other site 211586001859 hinge regions; other site 211586001860 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 211586001861 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211586001862 non-specific DNA binding site [nucleotide binding]; other site 211586001863 salt bridge; other site 211586001864 sequence-specific DNA binding site [nucleotide binding]; other site 211586001865 HipA N-terminal domain; Region: Couple_hipA; pfam13657 211586001866 HipA-like N-terminal domain; Region: HipA_N; pfam07805 211586001867 HipA-like C-terminal domain; Region: HipA_C; pfam07804 211586001868 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586001869 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586001870 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 211586001871 chaperone protein DnaJ; Provisional; Region: PRK14297 211586001872 Cytochrome c; Region: Cytochrom_C; cl11414 211586001873 sulfite oxidase; Provisional; Region: PLN00177 211586001874 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 211586001875 Moco binding site; other site 211586001876 metal coordination site [ion binding]; other site 211586001877 dimerization interface [polypeptide binding]; other site 211586001878 Cytochrome c; Region: Cytochrom_C; cl11414 211586001879 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 211586001880 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 211586001881 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 211586001882 N-terminal plug; other site 211586001883 ligand-binding site [chemical binding]; other site 211586001884 Protein of unknown function (DUF2999); Region: DUF2999; pfam11212 211586001885 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 211586001886 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 211586001887 heme binding site [chemical binding]; other site 211586001888 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 211586001889 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 211586001890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211586001891 ATP binding site [chemical binding]; other site 211586001892 Q-loop/lid; other site 211586001893 ABC transporter signature motif; other site 211586001894 Walker B; other site 211586001895 D-loop; other site 211586001896 H-loop/switch region; other site 211586001897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211586001898 Walker A/P-loop; other site 211586001899 ATP binding site [chemical binding]; other site 211586001900 Q-loop/lid; other site 211586001901 ABC transporter signature motif; other site 211586001902 Walker B; other site 211586001903 D-loop; other site 211586001904 H-loop/switch region; other site 211586001905 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 211586001906 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 211586001907 DNA binding residues [nucleotide binding] 211586001908 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 211586001909 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586001910 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 211586001911 catalytic residues [active] 211586001912 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 211586001913 DNA-binding site [nucleotide binding]; DNA binding site 211586001914 RNA-binding motif; other site 211586001915 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 211586001916 Predicted transcriptional regulators [Transcription]; Region: COG1695 211586001917 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211586001918 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 211586001919 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 211586001920 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 211586001921 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 211586001922 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 211586001923 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 211586001924 Walker A/P-loop; other site 211586001925 ATP binding site [chemical binding]; other site 211586001926 Q-loop/lid; other site 211586001927 ABC transporter signature motif; other site 211586001928 Walker B; other site 211586001929 D-loop; other site 211586001930 H-loop/switch region; other site 211586001931 TOBE domain; Region: TOBE_2; pfam08402 211586001932 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 211586001933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211586001934 dimer interface [polypeptide binding]; other site 211586001935 conserved gate region; other site 211586001936 putative PBP binding loops; other site 211586001937 ABC-ATPase subunit interface; other site 211586001938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211586001939 dimer interface [polypeptide binding]; other site 211586001940 conserved gate region; other site 211586001941 putative PBP binding loops; other site 211586001942 ABC-ATPase subunit interface; other site 211586001943 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 211586001944 putative glutathione S-transferase; Provisional; Region: PRK10357 211586001945 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 211586001946 putative C-terminal domain interface [polypeptide binding]; other site 211586001947 putative GSH binding site (G-site) [chemical binding]; other site 211586001948 putative dimer interface [polypeptide binding]; other site 211586001949 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 211586001950 substrate binding pocket (H-site) [chemical binding]; other site 211586001951 N-terminal domain interface [polypeptide binding]; other site 211586001952 ferredoxin-NADP reductase; Provisional; Region: PRK10926 211586001953 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 211586001954 FAD binding pocket [chemical binding]; other site 211586001955 FAD binding motif [chemical binding]; other site 211586001956 phosphate binding motif [ion binding]; other site 211586001957 beta-alpha-beta structure motif; other site 211586001958 NAD binding pocket [chemical binding]; other site 211586001959 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 211586001960 catalytic core [active] 211586001961 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 211586001962 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 211586001963 active site 211586001964 FMN binding site [chemical binding]; other site 211586001965 substrate binding site [chemical binding]; other site 211586001966 3Fe-4S cluster binding site [ion binding]; other site 211586001967 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211586001968 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 211586001969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211586001970 Walker A/P-loop; other site 211586001971 ATP binding site [chemical binding]; other site 211586001972 Q-loop/lid; other site 211586001973 ABC transporter signature motif; other site 211586001974 Walker B; other site 211586001975 D-loop; other site 211586001976 H-loop/switch region; other site 211586001977 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 211586001978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586001979 binding surface 211586001980 TPR motif; other site 211586001981 TPR repeat; Region: TPR_11; pfam13414 211586001982 probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644 211586001983 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 211586001984 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 211586001985 catalytic triad [active] 211586001986 dimer interface [polypeptide binding]; other site 211586001987 conserved cis-peptide bond; other site 211586001988 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 211586001989 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 211586001990 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 211586001991 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 211586001992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 211586001993 Putative NADH-flavin reductase [General function prediction only]; Region: COG2910 211586001994 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 211586001995 NAD(P) binding site [chemical binding]; other site 211586001996 active site 211586001997 arginine repressor; Provisional; Region: PRK05066 211586001998 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 211586001999 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 211586002000 malate dehydrogenase; Provisional; Region: PRK05086 211586002001 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 211586002002 NAD binding site [chemical binding]; other site 211586002003 dimerization interface [polypeptide binding]; other site 211586002004 Substrate binding site [chemical binding]; other site 211586002005 Protein of unknown function, DUF393; Region: DUF393; pfam04134 211586002006 dihydromonapterin reductase; Provisional; Region: PRK06483 211586002007 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 211586002008 NAD(P) binding site [chemical binding]; other site 211586002009 active site 211586002010 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 211586002011 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 211586002012 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586002013 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 211586002014 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 211586002015 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 211586002016 Cell division protein ZapA; Region: ZapA; pfam05164 211586002017 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 211586002018 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 211586002019 Squalene epoxidase; Region: SE; cl17314 211586002020 Squalene epoxidase; Region: SE; cl17314 211586002021 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 211586002022 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 211586002023 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 211586002024 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 211586002025 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 211586002026 lipoyl attachment site [posttranslational modification]; other site 211586002027 glycine dehydrogenase; Provisional; Region: PRK05367 211586002028 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 211586002029 tetramer interface [polypeptide binding]; other site 211586002030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586002031 catalytic residue [active] 211586002032 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 211586002033 tetramer interface [polypeptide binding]; other site 211586002034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586002035 catalytic residue [active] 211586002036 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 211586002037 Part of AAA domain; Region: AAA_19; pfam13245 211586002038 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 211586002039 tellurite resistance protein terB; Region: terB; cd07176 211586002040 putative metal binding site [ion binding]; other site 211586002041 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 211586002042 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 211586002043 short chain dehydrogenase; Region: adh_short; pfam00106 211586002044 putative NAD(P) binding site [chemical binding]; other site 211586002045 homodimer interface [polypeptide binding]; other site 211586002046 Ribosome recycling factor; Region: RRF_GI; pfam12614 211586002047 YcaO domain protein; Region: TIGR03549 211586002048 OsmC-like protein; Region: OsmC; pfam02566 211586002049 Uncharacterized conserved protein [Function unknown]; Region: COG1944 211586002050 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586002051 metal binding site [ion binding]; metal-binding site 211586002052 active site 211586002053 I-site; other site 211586002054 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 211586002055 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 211586002056 N-terminal plug; other site 211586002057 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 211586002058 ligand-binding site [chemical binding]; other site 211586002059 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 211586002060 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 211586002061 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 211586002062 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 211586002063 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 211586002064 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 211586002065 FOG: CBS domain [General function prediction only]; Region: COG0517 211586002066 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_15; cd04803 211586002067 PhoD-like phosphatase; Region: PhoD; pfam09423 211586002068 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 211586002069 putative active site [active] 211586002070 putative metal binding site [ion binding]; other site 211586002071 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211586002072 active site 211586002073 Protein of unknown function (DUF3622); Region: DUF3622; pfam12286 211586002074 Azurin is a redox partner for enzymes such as nitrite reductase or arsenite oxidase; Region: Azurin; cd13922 211586002075 Type 1 (T1) Cu binding site [ion binding]; other site 211586002076 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 211586002077 substrate binding site [chemical binding]; other site 211586002078 dimer interface [polypeptide binding]; other site 211586002079 ATP binding site [chemical binding]; other site 211586002080 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 211586002081 active site 211586002082 tetramer interface [polypeptide binding]; other site 211586002083 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 211586002084 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 211586002085 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 211586002086 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 211586002087 N-terminal plug; other site 211586002088 ligand-binding site [chemical binding]; other site 211586002089 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 211586002090 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586002091 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586002092 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 211586002093 putative dimerization interface [polypeptide binding]; other site 211586002094 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 211586002095 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 211586002096 THF binding site; other site 211586002097 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 211586002098 substrate binding site [chemical binding]; other site 211586002099 THF binding site; other site 211586002100 zinc-binding site [ion binding]; other site 211586002101 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 211586002102 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 211586002103 macrolide transporter subunit MacA; Provisional; Region: PRK11578 211586002104 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 211586002105 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 211586002106 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586002107 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 211586002108 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 211586002109 Walker A/P-loop; other site 211586002110 ATP binding site [chemical binding]; other site 211586002111 Q-loop/lid; other site 211586002112 ABC transporter signature motif; other site 211586002113 Walker B; other site 211586002114 D-loop; other site 211586002115 H-loop/switch region; other site 211586002116 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 211586002117 FtsX-like permease family; Region: FtsX; pfam02687 211586002118 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 211586002119 Outer membrane efflux protein; Region: OEP; pfam02321 211586002120 Outer membrane efflux protein; Region: OEP; pfam02321 211586002121 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 211586002122 Peptidase family M50; Region: Peptidase_M50; pfam02163 211586002123 active site 211586002124 putative substrate binding region [chemical binding]; other site 211586002125 protein structure with unknown function; Region: DUF4144; pfam13642 211586002126 Protein of unknown function (DUF342); Region: DUF342; pfam03961 211586002127 L-lactate permease; Region: Lactate_perm; cl00701 211586002128 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 211586002129 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 211586002130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586002131 S-adenosylmethionine binding site [chemical binding]; other site 211586002132 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl19058 211586002133 dimer interface [polypeptide binding]; other site 211586002134 active site 211586002135 glutathione synthetase; Provisional; Region: PRK05246 211586002136 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 211586002137 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 211586002138 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 211586002139 Endonuclease I; Region: Endonuclease_1; cl01003 211586002140 hypothetical protein; Provisional; Region: PRK04860 211586002141 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 211586002142 putative substrate binding pocket [chemical binding]; other site 211586002143 AC domain interface; other site 211586002144 catalytic triad [active] 211586002145 AB domain interface; other site 211586002146 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 211586002147 LysR family transcriptional regulator; Provisional; Region: PRK14997 211586002148 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586002149 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 211586002150 putative effector binding pocket; other site 211586002151 dimerization interface [polypeptide binding]; other site 211586002152 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 211586002153 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 211586002154 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 211586002155 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 211586002156 ATP-grasp domain; Region: ATP-grasp_4; cl17255 211586002157 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 211586002158 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 211586002159 carboxyltransferase (CT) interaction site; other site 211586002160 biotinylation site [posttranslational modification]; other site 211586002161 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211586002162 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211586002163 substrate binding pocket [chemical binding]; other site 211586002164 membrane-bound complex binding site; other site 211586002165 hinge residues; other site 211586002166 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586002167 metal binding site [ion binding]; metal-binding site 211586002168 active site 211586002169 I-site; other site 211586002170 elongation factor G; Reviewed; Region: PRK00007 211586002171 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 211586002172 G1 box; other site 211586002173 putative GEF interaction site [polypeptide binding]; other site 211586002174 GTP/Mg2+ binding site [chemical binding]; other site 211586002175 Switch I region; other site 211586002176 G2 box; other site 211586002177 G3 box; other site 211586002178 Switch II region; other site 211586002179 G4 box; other site 211586002180 G5 box; other site 211586002181 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 211586002182 Elongation Factor G, domain II; Region: EFG_II; pfam14492 211586002183 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 211586002184 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 211586002185 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586002186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586002187 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 211586002188 putative dimerization interface [polypeptide binding]; other site 211586002189 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 211586002190 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 211586002191 4Fe-4S binding domain; Region: Fer4_5; pfam12801 211586002192 4Fe-4S binding domain; Region: Fer4_5; pfam12801 211586002193 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 211586002194 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 211586002195 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 211586002196 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 211586002197 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 211586002198 [4Fe-4S] binding site [ion binding]; other site 211586002199 molybdopterin cofactor binding site; other site 211586002200 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 211586002201 molybdopterin cofactor binding site; other site 211586002202 NapD protein; Region: NapD; pfam03927 211586002203 PilX N-terminal; Region: PilX_N; pfam14341 211586002204 Protein of unknown function (DUF342); Region: DUF342; cl19219 211586002205 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 211586002206 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 211586002207 Type II transport protein GspH; Region: GspH; pfam12019 211586002208 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 211586002209 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 211586002210 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 211586002211 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 211586002212 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 211586002213 FtsX-like permease family; Region: FtsX; pfam02687 211586002214 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 211586002215 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 211586002216 Walker A/P-loop; other site 211586002217 ATP binding site [chemical binding]; other site 211586002218 Q-loop/lid; other site 211586002219 ABC transporter signature motif; other site 211586002220 Walker B; other site 211586002221 D-loop; other site 211586002222 H-loop/switch region; other site 211586002223 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 211586002224 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 211586002225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586002226 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 211586002227 putative active site [active] 211586002228 heme pocket [chemical binding]; other site 211586002229 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 211586002230 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586002231 putative active site [active] 211586002232 heme pocket [chemical binding]; other site 211586002233 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 211586002234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586002235 putative active site [active] 211586002236 heme pocket [chemical binding]; other site 211586002237 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586002238 putative active site [active] 211586002239 heme pocket [chemical binding]; other site 211586002240 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586002241 dimer interface [polypeptide binding]; other site 211586002242 phosphorylation site [posttranslational modification] 211586002243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586002244 ATP binding site [chemical binding]; other site 211586002245 Mg2+ binding site [ion binding]; other site 211586002246 G-X-G motif; other site 211586002247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586002248 active site 211586002249 phosphorylation site [posttranslational modification] 211586002250 intermolecular recognition site; other site 211586002251 dimerization interface [polypeptide binding]; other site 211586002252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586002253 active site 211586002254 phosphorylation site [posttranslational modification] 211586002255 intermolecular recognition site; other site 211586002256 dimerization interface [polypeptide binding]; other site 211586002257 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 211586002258 putative binding surface; other site 211586002259 active site 211586002260 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 211586002261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586002262 active site 211586002263 phosphorylation site [posttranslational modification] 211586002264 intermolecular recognition site; other site 211586002265 dimerization interface [polypeptide binding]; other site 211586002266 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211586002267 Zn2+ binding site [ion binding]; other site 211586002268 Mg2+ binding site [ion binding]; other site 211586002269 putative global regulator; Reviewed; Region: PRK09559 211586002270 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 211586002271 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 211586002272 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 211586002273 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 211586002274 ligand binding site [chemical binding]; other site 211586002275 NAD binding site [chemical binding]; other site 211586002276 tetramer interface [polypeptide binding]; other site 211586002277 catalytic site [active] 211586002278 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 211586002279 L-serine binding site [chemical binding]; other site 211586002280 ACT domain interface; other site 211586002281 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 211586002282 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 211586002283 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 211586002284 DNA binding residues [nucleotide binding] 211586002285 dimerization interface [polypeptide binding]; other site 211586002286 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 211586002287 Curlin associated repeat; Region: Curlin_rpt; pfam07012 211586002288 Curlin associated repeat; Region: Curlin_rpt; pfam07012 211586002289 Curlin associated repeat; Region: Curlin_rpt; pfam07012 211586002290 major curlin subunit; Provisional; Region: csgA; PRK10051 211586002291 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 211586002292 Curlin associated repeat; Region: Curlin_rpt; pfam07012 211586002293 Curlin associated repeat; Region: Curlin_rpt; pfam07012 211586002294 Curlin associated repeat; Region: Curlin_rpt; pfam07012 211586002295 Curlin associated repeat; Region: Curlin_rpt; pfam07012 211586002296 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 211586002297 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 211586002298 Subtilase family; Region: Peptidase_S8; pfam00082 211586002299 catalytic triad [active] 211586002300 putative active site [active] 211586002301 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 211586002302 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 211586002303 FOG: PKD repeat [General function prediction only]; Region: COG3291 211586002304 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 211586002305 Pantoate-beta-alanine ligase; Region: PanC; cd00560 211586002306 active site 211586002307 ATP-binding site [chemical binding]; other site 211586002308 pantoate-binding site; other site 211586002309 HXXH motif; other site 211586002310 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 211586002311 oligomerization interface [polypeptide binding]; other site 211586002312 active site 211586002313 metal binding site [ion binding]; metal-binding site 211586002314 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 211586002315 catalytic center binding site [active] 211586002316 ATP binding site [chemical binding]; other site 211586002317 poly(A) polymerase; Region: pcnB; TIGR01942 211586002318 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 211586002319 active site 211586002320 NTP binding site [chemical binding]; other site 211586002321 metal binding triad [ion binding]; metal-binding site 211586002322 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 211586002323 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 211586002324 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 211586002325 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 211586002326 active site 211586002327 nucleotide binding site [chemical binding]; other site 211586002328 HIGH motif; other site 211586002329 KMSKS motif; other site 211586002330 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 211586002331 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 211586002332 aminopeptidase B; Provisional; Region: PRK05015 211586002333 Peptidase; Region: DUF3663; pfam12404 211586002334 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 211586002335 interface (dimer of trimers) [polypeptide binding]; other site 211586002336 Substrate-binding/catalytic site; other site 211586002337 Zn-binding sites [ion binding]; other site 211586002338 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 211586002339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586002340 Coenzyme A binding pocket [chemical binding]; other site 211586002341 phosphoribulokinase; Provisional; Region: PRK15453 211586002342 active site 211586002343 Uncharacterized protein family (UPF0270); Region: UPF0270; pfam06794 211586002344 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 211586002345 Putative lysophospholipase; Region: Hydrolase_4; cl19140 211586002346 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 211586002347 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 211586002348 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 211586002349 Uncharacterized conserved protein [Function unknown]; Region: COG3791 211586002350 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 211586002351 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 211586002352 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 211586002353 ABC transporter; Region: ABC_tran_2; pfam12848 211586002354 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 211586002355 conserved hypothetical metal-binding protein; Region: TIGR02443 211586002356 agmatine deiminase; Provisional; Region: PRK13551 211586002357 amidase; Validated; Region: PRK06565 211586002358 Transposase; Region: HTH_Tnp_1; pfam01527 211586002359 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586002360 putative transposase OrfB; Reviewed; Region: PHA02517 211586002361 HTH-like domain; Region: HTH_21; pfam13276 211586002362 Integrase core domain; Region: rve; pfam00665 211586002363 Integrase core domain; Region: rve_2; pfam13333 211586002364 Pirin-related protein [General function prediction only]; Region: COG1741 211586002365 Pirin; Region: Pirin; pfam02678 211586002366 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 211586002367 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 211586002368 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 211586002369 ATP binding site [chemical binding]; other site 211586002370 Mg++ binding site [ion binding]; other site 211586002371 motif III; other site 211586002372 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586002373 nucleotide binding region [chemical binding]; other site 211586002374 ATP-binding site [chemical binding]; other site 211586002375 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 211586002376 putative RNA binding site [nucleotide binding]; other site 211586002377 Uncharacterized protein family (UPF0167); Region: UPF0167; pfam03691 211586002378 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 211586002379 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 211586002380 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 211586002381 active site 211586002382 catalytic tetrad [active] 211586002383 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 211586002384 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 211586002385 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 211586002386 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 211586002387 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 211586002388 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 211586002389 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 211586002390 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 211586002391 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 211586002392 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 211586002393 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 211586002394 FAD binding pocket [chemical binding]; other site 211586002395 FAD binding motif [chemical binding]; other site 211586002396 phosphate binding motif [ion binding]; other site 211586002397 beta-alpha-beta structure motif; other site 211586002398 NAD binding pocket [chemical binding]; other site 211586002399 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 211586002400 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 211586002401 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 211586002402 Fic/DOC family; Region: Fic; cl00960 211586002403 Beta-lactamase; Region: Beta-lactamase; pfam00144 211586002404 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 211586002405 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 211586002406 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 211586002407 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 211586002408 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 211586002409 Transcriptional regulators [Transcription]; Region: MarR; COG1846 211586002410 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 211586002411 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 211586002412 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586002413 Coenzyme A binding pocket [chemical binding]; other site 211586002414 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 211586002415 Penicillin amidase; Region: Penicil_amidase; pfam01804 211586002416 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 211586002417 active site 211586002418 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 211586002419 serine transporter; Region: stp; TIGR00814 211586002420 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 211586002421 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586002422 Coenzyme A binding pocket [chemical binding]; other site 211586002423 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 211586002424 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 211586002425 META domain; Region: META; pfam03724 211586002426 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 211586002427 metal binding site [ion binding]; metal-binding site 211586002428 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 211586002429 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586002430 metal binding site [ion binding]; metal-binding site 211586002431 active site 211586002432 I-site; other site 211586002433 S-adenosylmethionine synthetase; Validated; Region: PRK05250 211586002434 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 211586002435 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 211586002436 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 211586002437 transketolase; Reviewed; Region: PRK12753 211586002438 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 211586002439 TPP-binding site [chemical binding]; other site 211586002440 dimer interface [polypeptide binding]; other site 211586002441 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 211586002442 PYR/PP interface [polypeptide binding]; other site 211586002443 dimer interface [polypeptide binding]; other site 211586002444 TPP binding site [chemical binding]; other site 211586002445 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 211586002446 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 211586002447 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 211586002448 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 211586002449 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 211586002450 substrate binding site [chemical binding]; other site 211586002451 hinge regions; other site 211586002452 ADP binding site [chemical binding]; other site 211586002453 catalytic site [active] 211586002454 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 211586002455 intersubunit interface [polypeptide binding]; other site 211586002456 active site 211586002457 zinc binding site [ion binding]; other site 211586002458 Na+ binding site [ion binding]; other site 211586002459 Protein of unknown function, DUF481; Region: DUF481; pfam04338 211586002460 Citrate transporter; Region: CitMHS; pfam03600 211586002461 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 211586002462 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 211586002463 DNA binding site [nucleotide binding] 211586002464 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211586002465 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 211586002466 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 211586002467 DNA binding site [nucleotide binding] 211586002468 PAS domain; Region: PAS_9; pfam13426 211586002469 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586002470 putative active site [active] 211586002471 heme pocket [chemical binding]; other site 211586002472 PAS domain; Region: PAS_9; pfam13426 211586002473 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 211586002474 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 211586002475 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211586002476 FeS/SAM binding site; other site 211586002477 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 211586002478 MMPL family; Region: MMPL; cl14618 211586002479 MMPL family; Region: MMPL; cl14618 211586002480 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 211586002481 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586002482 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 211586002483 DEAD-like helicases superfamily; Region: DEXDc; smart00487 211586002484 ATP binding site [chemical binding]; other site 211586002485 Mg++ binding site [ion binding]; other site 211586002486 motif III; other site 211586002487 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586002488 nucleotide binding region [chemical binding]; other site 211586002489 ATP-binding site [chemical binding]; other site 211586002490 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 211586002491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586002492 S-adenosylmethionine binding site [chemical binding]; other site 211586002493 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 211586002494 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 211586002495 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 211586002496 active site 211586002497 Int/Topo IB signature motif; other site 211586002498 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 211586002499 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 211586002500 dimerization domain [polypeptide binding]; other site 211586002501 dimer interface [polypeptide binding]; other site 211586002502 catalytic residues [active] 211586002503 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 211586002504 DHH family; Region: DHH; pfam01368 211586002505 DHHA1 domain; Region: DHHA1; pfam02272 211586002506 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 211586002507 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586002508 Coenzyme A binding pocket [chemical binding]; other site 211586002509 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 211586002510 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 211586002511 catalytic residue [active] 211586002512 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 211586002513 catalytic residues [active] 211586002514 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 211586002515 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 211586002516 peroxiredoxin; Region: AhpC; TIGR03137 211586002517 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 211586002518 dimer interface [polypeptide binding]; other site 211586002519 decamer (pentamer of dimers) interface [polypeptide binding]; other site 211586002520 catalytic triad [active] 211586002521 peroxidatic and resolving cysteines [active] 211586002522 multifunctional aminopeptidase A; Provisional; Region: PRK00913 211586002523 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 211586002524 interface (dimer of trimers) [polypeptide binding]; other site 211586002525 Substrate-binding/catalytic site; other site 211586002526 Zn-binding sites [ion binding]; other site 211586002527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586002528 S-adenosylmethionine binding site [chemical binding]; other site 211586002529 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 211586002530 Mechanosensitive ion channel; Region: MS_channel; pfam00924 211586002531 Domain of unknown function (DUF3332); Region: DUF3332; pfam11810 211586002532 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 211586002533 Transposase; Region: HTH_Tnp_1; pfam01527 211586002534 Winged helix-turn helix; Region: HTH_29; pfam13551 211586002535 HTH-like domain; Region: HTH_21; pfam13276 211586002536 Integrase core domain; Region: rve; pfam00665 211586002537 Integrase core domain; Region: rve_3; pfam13683 211586002538 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 211586002539 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 211586002540 putative ligand binding site [chemical binding]; other site 211586002541 putative NAD binding site [chemical binding]; other site 211586002542 catalytic site [active] 211586002543 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 211586002544 heme-binding residues [chemical binding]; other site 211586002545 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 211586002546 L-aspartate oxidase; Provisional; Region: PRK06175 211586002547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586002548 S-adenosylmethionine binding site [chemical binding]; other site 211586002549 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 211586002550 Sulfite exporter TauE/SafE; Region: TauE; cl19196 211586002551 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 211586002552 Transcriptional regulators [Transcription]; Region: MarR; COG1846 211586002553 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 211586002554 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 211586002555 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 211586002556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586002557 S-adenosylmethionine binding site [chemical binding]; other site 211586002558 Transposase; Region: HTH_Tnp_1; pfam01527 211586002559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586002560 putative transposase OrfB; Reviewed; Region: PHA02517 211586002561 HTH-like domain; Region: HTH_21; pfam13276 211586002562 Integrase core domain; Region: rve; pfam00665 211586002563 Integrase core domain; Region: rve_2; pfam13333 211586002564 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 211586002565 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 211586002566 Chromate transporter; Region: Chromate_transp; pfam02417 211586002567 Cache domain; Region: Cache_2; pfam08269 211586002568 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 211586002569 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586002570 dimerization interface [polypeptide binding]; other site 211586002571 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 211586002572 dimer interface [polypeptide binding]; other site 211586002573 putative CheW interface [polypeptide binding]; other site 211586002574 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 211586002575 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 211586002576 catalytic loop [active] 211586002577 iron binding site [ion binding]; other site 211586002578 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 211586002579 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 211586002580 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 211586002581 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 211586002582 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 211586002583 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 211586002584 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 211586002585 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 211586002586 [4Fe-4S] binding site [ion binding]; other site 211586002587 molybdopterin cofactor binding site; other site 211586002588 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 211586002589 molybdopterin cofactor binding site; other site 211586002590 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586002591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586002592 LysR substrate binding domain; Region: LysR_substrate; pfam03466 211586002593 dimerization interface [polypeptide binding]; other site 211586002594 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 211586002595 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 211586002596 active site 211586002597 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 211586002598 peptide chain release factor 2; Validated; Region: prfB; PRK00578 211586002599 This domain is found in peptide chain release factors; Region: PCRF; smart00937 211586002600 RF-1 domain; Region: RF-1; pfam00472 211586002601 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 211586002602 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 211586002603 dimer interface [polypeptide binding]; other site 211586002604 putative anticodon binding site; other site 211586002605 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 211586002606 motif 1; other site 211586002607 active site 211586002608 motif 2; other site 211586002609 motif 3; other site 211586002610 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 211586002611 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 211586002612 active site 211586002613 metal binding site [ion binding]; metal-binding site 211586002614 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586002615 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586002616 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 211586002617 dimerization interface [polypeptide binding]; other site 211586002618 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 211586002619 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 211586002620 Rhomboid family; Region: Rhomboid; pfam01694 211586002621 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 211586002622 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 211586002623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 211586002624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 211586002625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 211586002626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 211586002627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 211586002628 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 211586002629 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 211586002630 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 211586002631 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 211586002632 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 211586002633 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586002634 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 211586002635 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 211586002636 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 211586002637 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 211586002638 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 211586002639 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 211586002640 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 211586002641 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 211586002642 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 211586002643 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 211586002644 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 211586002645 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 211586002646 NADH dehydrogenase subunit G; Validated; Region: PRK08166 211586002647 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 211586002648 catalytic loop [active] 211586002649 iron binding site [ion binding]; other site 211586002650 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 211586002651 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 211586002652 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 211586002653 [4Fe-4S] binding site [ion binding]; other site 211586002654 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 211586002655 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 211586002656 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 211586002657 SLBB domain; Region: SLBB; pfam10531 211586002658 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 211586002659 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 211586002660 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 211586002661 putative dimer interface [polypeptide binding]; other site 211586002662 [2Fe-2S] cluster binding site [ion binding]; other site 211586002663 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 211586002664 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 211586002665 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 211586002666 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 211586002667 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 211586002668 Transposase; Region: HTH_Tnp_1; pfam01527 211586002669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586002670 putative transposase OrfB; Reviewed; Region: PHA02517 211586002671 HTH-like domain; Region: HTH_21; pfam13276 211586002672 Integrase core domain; Region: rve; pfam00665 211586002673 Integrase core domain; Region: rve_2; pfam13333 211586002674 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586002675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586002676 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 211586002677 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 211586002678 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 211586002679 substrate binding pocket [chemical binding]; other site 211586002680 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 211586002681 B12 binding site [chemical binding]; other site 211586002682 cobalt ligand [ion binding]; other site 211586002683 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 211586002684 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 211586002685 catalytic core [active] 211586002686 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 211586002687 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 211586002688 Walker A/P-loop; other site 211586002689 ATP binding site [chemical binding]; other site 211586002690 Q-loop/lid; other site 211586002691 ABC transporter signature motif; other site 211586002692 Walker B; other site 211586002693 D-loop; other site 211586002694 H-loop/switch region; other site 211586002695 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 211586002696 ABC-ATPase subunit interface; other site 211586002697 dimer interface [polypeptide binding]; other site 211586002698 putative PBP binding regions; other site 211586002699 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 211586002700 putative dimer interface [polypeptide binding]; other site 211586002701 active site pocket [active] 211586002702 putative cataytic base [active] 211586002703 cobalamin synthase; Reviewed; Region: cobS; PRK00235 211586002704 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 211586002705 cobyric acid synthase; Provisional; Region: PRK00784 211586002706 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 211586002707 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 211586002708 catalytic triad [active] 211586002709 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 211586002710 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 211586002711 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 211586002712 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 211586002713 Walker A/P-loop; other site 211586002714 ATP binding site [chemical binding]; other site 211586002715 Q-loop/lid; other site 211586002716 ABC transporter signature motif; other site 211586002717 Walker B; other site 211586002718 D-loop; other site 211586002719 H-loop/switch region; other site 211586002720 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 211586002721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211586002722 dimer interface [polypeptide binding]; other site 211586002723 conserved gate region; other site 211586002724 putative PBP binding loops; other site 211586002725 ABC-ATPase subunit interface; other site 211586002726 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211586002727 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211586002728 substrate binding pocket [chemical binding]; other site 211586002729 membrane-bound complex binding site; other site 211586002730 hinge residues; other site 211586002731 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586002732 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586002733 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 211586002734 putative dimerization interface [polypeptide binding]; other site 211586002735 LrgA family; Region: LrgA; pfam03788 211586002736 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 211586002737 G4 box; other site 211586002738 LrgB-like family; Region: LrgB; pfam04172 211586002739 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 211586002740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 211586002741 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 211586002742 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 211586002743 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 211586002744 tetramer interface [polypeptide binding]; other site 211586002745 active site 211586002746 Mg2+/Mn2+ binding site [ion binding]; other site 211586002747 PAS domain; Region: PAS_9; pfam13426 211586002748 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586002749 putative active site [active] 211586002750 heme pocket [chemical binding]; other site 211586002751 GAF domain; Region: GAF_2; pfam13185 211586002752 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586002753 metal binding site [ion binding]; metal-binding site 211586002754 active site 211586002755 I-site; other site 211586002756 Cache domain; Region: Cache_1; pfam02743 211586002757 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 211586002758 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586002759 dimerization interface [polypeptide binding]; other site 211586002760 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 211586002761 dimer interface [polypeptide binding]; other site 211586002762 putative CheW interface [polypeptide binding]; other site 211586002763 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 211586002764 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 211586002765 Zn binding site [ion binding]; other site 211586002766 ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838 211586002767 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 211586002768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 211586002769 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 211586002770 active site 211586002771 catalytic residues [active] 211586002772 metal binding site [ion binding]; metal-binding site 211586002773 SlyX; Region: SlyX; pfam04102 211586002774 FOG: WD40 repeat [General function prediction only]; Region: COG2319 211586002775 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 211586002776 structural tetrad; other site 211586002777 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 211586002778 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 211586002779 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 211586002780 Lamin Tail Domain; Region: LTD; pfam00932 211586002781 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 211586002782 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 211586002783 generic binding surface II; other site 211586002784 generic binding surface I; other site 211586002785 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 211586002786 putative catalytic site [active] 211586002787 putative metal binding site [ion binding]; other site 211586002788 putative phosphate binding site [ion binding]; other site 211586002789 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 211586002790 CoenzymeA binding site [chemical binding]; other site 211586002791 subunit interaction site [polypeptide binding]; other site 211586002792 PHB binding site; other site 211586002793 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 211586002794 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 211586002795 tetramer interface [polypeptide binding]; other site 211586002796 heme binding pocket [chemical binding]; other site 211586002797 NADPH binding site [chemical binding]; other site 211586002798 Predicted membrane protein [Function unknown]; Region: COG2119 211586002799 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 211586002800 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 211586002801 yybP-ykoY riboswitch 211586002802 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 211586002803 Chitin binding domain; Region: Chitin_bind_3; pfam03067 211586002804 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 211586002805 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 211586002806 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 211586002807 Peptidase S46; Region: Peptidase_S46; pfam10459 211586002808 Transposase; Region: HTH_Tnp_1; pfam01527 211586002809 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586002810 putative transposase OrfB; Reviewed; Region: PHA02517 211586002811 HTH-like domain; Region: HTH_21; pfam13276 211586002812 Integrase core domain; Region: rve; pfam00665 211586002813 Integrase core domain; Region: rve_2; pfam13333 211586002814 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 211586002815 Transposase; Region: HTH_Tnp_1; pfam01527 211586002816 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586002817 putative transposase OrfB; Reviewed; Region: PHA02517 211586002818 HTH-like domain; Region: HTH_21; pfam13276 211586002819 Integrase core domain; Region: rve; pfam00665 211586002820 Integrase core domain; Region: rve_2; pfam13333 211586002821 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 211586002822 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211586002823 RNA binding surface [nucleotide binding]; other site 211586002824 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 211586002825 probable active site [active] 211586002826 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 211586002827 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 211586002828 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 211586002829 ApbE family; Region: ApbE; pfam02424 211586002830 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 211586002831 EamA-like transporter family; Region: EamA; pfam00892 211586002832 EamA-like transporter family; Region: EamA; pfam00892 211586002833 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 211586002834 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 211586002835 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 211586002836 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 211586002837 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586002838 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 211586002839 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 211586002840 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 211586002841 homodimer interface [polypeptide binding]; other site 211586002842 substrate-cofactor binding pocket; other site 211586002843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586002844 catalytic residue [active] 211586002845 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 211586002846 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 211586002847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586002848 S-adenosylmethionine binding site [chemical binding]; other site 211586002849 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 211586002850 BolA-like protein; Region: BolA; cl00386 211586002851 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 211586002852 S-ribosylhomocysteinase; Provisional; Region: PRK02260 211586002853 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 211586002854 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 211586002855 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 211586002856 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 211586002857 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 211586002858 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 211586002859 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 211586002860 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 211586002861 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 211586002862 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 211586002863 FAD binding pocket [chemical binding]; other site 211586002864 FAD binding motif [chemical binding]; other site 211586002865 phosphate binding motif [ion binding]; other site 211586002866 beta-alpha-beta structure motif; other site 211586002867 NAD binding pocket [chemical binding]; other site 211586002868 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 211586002869 Protein of unknown function (DUF539); Region: DUF539; cl01129 211586002870 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 211586002871 Ferritin-like domain; Region: Ferritin; pfam00210 211586002872 heme binding site [chemical binding]; other site 211586002873 ferroxidase pore; other site 211586002874 ferroxidase diiron center [ion binding]; other site 211586002875 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 211586002876 Ferritin-like domain; Region: Ferritin; pfam00210 211586002877 heme binding site [chemical binding]; other site 211586002878 ferroxidase pore; other site 211586002879 ferroxidase diiron center [ion binding]; other site 211586002880 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 211586002881 active site 211586002882 DNA polymerase IV; Validated; Region: PRK02406 211586002883 DNA binding site [nucleotide binding] 211586002884 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 211586002885 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 211586002886 metal binding site [ion binding]; metal-binding site 211586002887 dimer interface [polypeptide binding]; other site 211586002888 multifunctional aminopeptidase A; Provisional; Region: PRK00913 211586002889 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 211586002890 interface (dimer of trimers) [polypeptide binding]; other site 211586002891 Substrate-binding/catalytic site; other site 211586002892 Zn-binding sites [ion binding]; other site 211586002893 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 211586002894 Sulfate transporter family; Region: Sulfate_transp; cl19250 211586002895 gamma-glutamyl kinase; Provisional; Region: PRK05429 211586002896 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 211586002897 nucleotide binding site [chemical binding]; other site 211586002898 homotetrameric interface [polypeptide binding]; other site 211586002899 putative phosphate binding site [ion binding]; other site 211586002900 putative allosteric binding site; other site 211586002901 PUA domain; Region: PUA; pfam01472 211586002902 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 211586002903 putative catalytic cysteine [active] 211586002904 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 211586002905 putative deacylase active site [active] 211586002906 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 211586002907 EamA-like transporter family; Region: EamA; pfam00892 211586002908 EamA-like transporter family; Region: EamA; pfam00892 211586002909 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 211586002910 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 211586002911 nucleotide binding site [chemical binding]; other site 211586002912 chaperone protein DnaJ; Provisional; Region: PRK10767 211586002913 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 211586002914 HSP70 interaction site [polypeptide binding]; other site 211586002915 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 211586002916 substrate binding site [polypeptide binding]; other site 211586002917 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 211586002918 Zn binding sites [ion binding]; other site 211586002919 dimer interface [polypeptide binding]; other site 211586002920 Transposase; Region: HTH_Tnp_1; pfam01527 211586002921 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586002922 putative transposase OrfB; Reviewed; Region: PHA02517 211586002923 HTH-like domain; Region: HTH_21; pfam13276 211586002924 Integrase core domain; Region: rve; pfam00665 211586002925 Integrase core domain; Region: rve_2; pfam13333 211586002926 Transposase; Region: HTH_Tnp_1; pfam01527 211586002927 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586002928 putative transposase OrfB; Reviewed; Region: PHA02517 211586002929 HTH-like domain; Region: HTH_21; pfam13276 211586002930 Integrase core domain; Region: rve; pfam00665 211586002931 Integrase core domain; Region: rve_2; pfam13333 211586002932 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 211586002933 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 211586002934 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 211586002935 ATP binding site [chemical binding]; other site 211586002936 Mg++ binding site [ion binding]; other site 211586002937 motif III; other site 211586002938 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586002939 nucleotide binding region [chemical binding]; other site 211586002940 ATP-binding site [chemical binding]; other site 211586002941 Peptidase family M48; Region: Peptidase_M48; pfam01435 211586002942 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 211586002943 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 211586002944 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 211586002945 dihydrodipicolinate reductase; Provisional; Region: PRK00048 211586002946 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 211586002947 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 211586002948 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 211586002949 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 211586002950 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 211586002951 catalytic site [active] 211586002952 subunit interface [polypeptide binding]; other site 211586002953 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 211586002954 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 211586002955 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 211586002956 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 211586002957 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 211586002958 ATP-grasp domain; Region: ATP-grasp_4; cl17255 211586002959 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 211586002960 IMP binding site; other site 211586002961 dimer interface [polypeptide binding]; other site 211586002962 interdomain contacts; other site 211586002963 partial ornithine binding site; other site 211586002964 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 211586002965 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211586002966 substrate binding pocket [chemical binding]; other site 211586002967 membrane-bound complex binding site; other site 211586002968 hinge residues; other site 211586002969 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 211586002970 dimer interface [polypeptide binding]; other site 211586002971 putative CheW interface [polypeptide binding]; other site 211586002972 Chemoreceptor zinc-binding domain; Region: CZB; pfam13682 211586002973 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 211586002974 MgtE intracellular N domain; Region: MgtE_N; pfam03448 211586002975 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 211586002976 Divalent cation transporter; Region: MgtE; cl00786 211586002977 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 211586002978 putative catalytic site [active] 211586002979 putative metal binding site [ion binding]; other site 211586002980 putative phosphate binding site [ion binding]; other site 211586002981 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 211586002982 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 211586002983 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 211586002984 putative RNA binding site [nucleotide binding]; other site 211586002985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586002986 S-adenosylmethionine binding site [chemical binding]; other site 211586002987 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 211586002988 tetramer (dimer of dimers) interface [polypeptide binding]; other site 211586002989 active site 211586002990 dimer interface [polypeptide binding]; other site 211586002991 Protein of unknown function (DUF808); Region: DUF808; pfam05661 211586002992 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 211586002993 catalytic site [active] 211586002994 putative active site [active] 211586002995 putative substrate binding site [chemical binding]; other site 211586002996 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 211586002997 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 211586002998 N-terminal plug; other site 211586002999 ligand-binding site [chemical binding]; other site 211586003000 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 211586003001 Ferritin-like domain; Region: Ferritin; pfam00210 211586003002 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 211586003003 dimerization interface [polypeptide binding]; other site 211586003004 DPS ferroxidase diiron center [ion binding]; other site 211586003005 ion pore; other site 211586003006 DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436 211586003007 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 211586003008 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586003009 Coenzyme A binding pocket [chemical binding]; other site 211586003010 lipoyl synthase; Provisional; Region: PRK05481 211586003011 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211586003012 FeS/SAM binding site; other site 211586003013 lipoate-protein ligase B; Provisional; Region: PRK14342 211586003014 hypothetical protein; Provisional; Region: PRK04998 211586003015 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 211586003016 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 211586003017 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 211586003018 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 211586003019 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 211586003020 Sporulation related domain; Region: SPOR; pfam05036 211586003021 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 211586003022 lytic murein transglycosylase B; Region: MltB; TIGR02282 211586003023 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 211586003024 N-acetyl-D-glucosamine binding site [chemical binding]; other site 211586003025 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 211586003026 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 211586003027 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 211586003028 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 211586003029 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 211586003030 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 211586003031 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 211586003032 active site 211586003033 (T/H)XGH motif; other site 211586003034 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 211586003035 DNA polymerase III, delta subunit; Region: holA; TIGR01128 211586003036 Processivity clamp loader gamma complex DNA pol III C-term; Region: DNA_pol3_delt_C; pfam14840 211586003037 Lipopolysaccharide-assembly; Region: LptE; cl01125 211586003038 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 211586003039 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 211586003040 active site 211586003041 HIGH motif; other site 211586003042 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 211586003043 KMSKS motif; other site 211586003044 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 211586003045 tRNA binding surface [nucleotide binding]; other site 211586003046 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 211586003047 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 211586003048 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 211586003049 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 211586003050 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 211586003051 putative active site [active] 211586003052 catalytic triad [active] 211586003053 putative dimer interface [polypeptide binding]; other site 211586003054 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 211586003055 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 211586003056 Transporter associated domain; Region: CorC_HlyC; smart01091 211586003057 metal-binding heat shock protein; Provisional; Region: PRK00016 211586003058 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 211586003059 PhoH-like protein; Region: PhoH; pfam02562 211586003060 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 211586003061 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 211586003062 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211586003063 FeS/SAM binding site; other site 211586003064 TRAM domain; Region: TRAM; pfam01938 211586003065 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 211586003066 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 211586003067 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 211586003068 putative active site [active] 211586003069 catalytic residue [active] 211586003070 GTP-binding protein YchF; Reviewed; Region: PRK09601 211586003071 YchF GTPase; Region: YchF; cd01900 211586003072 G1 box; other site 211586003073 GTP/Mg2+ binding site [chemical binding]; other site 211586003074 Switch I region; other site 211586003075 G2 box; other site 211586003076 Switch II region; other site 211586003077 G3 box; other site 211586003078 G4 box; other site 211586003079 G5 box; other site 211586003080 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 211586003081 PepSY-associated TM helix; Region: PepSY_TM_1; cl19400 211586003082 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 211586003083 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 211586003084 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 211586003085 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 211586003086 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 211586003087 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 211586003088 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK12933 211586003089 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 211586003090 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 211586003091 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 211586003092 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13021 211586003093 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 211586003094 Protein export membrane protein; Region: SecD_SecF; pfam02355 211586003095 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 211586003096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586003097 S-adenosylmethionine binding site [chemical binding]; other site 211586003098 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 211586003099 FtsH Extracellular; Region: FtsH_ext; pfam06480 211586003100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586003101 Walker A motif; other site 211586003102 ATP binding site [chemical binding]; other site 211586003103 Walker B motif; other site 211586003104 arginine finger; other site 211586003105 Peptidase family M41; Region: Peptidase_M41; pfam01434 211586003106 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 211586003107 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 211586003108 substrate binding pocket [chemical binding]; other site 211586003109 dimer interface [polypeptide binding]; other site 211586003110 inhibitor binding site; inhibition site 211586003111 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 211586003112 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 211586003113 active site 211586003114 substrate binding site [chemical binding]; other site 211586003115 metal binding site [ion binding]; metal-binding site 211586003116 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 211586003117 substrate binding site [chemical binding]; other site 211586003118 dimer interface [polypeptide binding]; other site 211586003119 catalytic triad [active] 211586003120 Preprotein translocase SecG subunit; Region: SecG; pfam03840 211586003121 Sm and related proteins; Region: Sm_like; cl00259 211586003122 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 211586003123 putative oligomer interface [polypeptide binding]; other site 211586003124 putative RNA binding site [nucleotide binding]; other site 211586003125 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 211586003126 NusA N-terminal domain; Region: NusA_N; pfam08529 211586003127 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 211586003128 RNA binding site [nucleotide binding]; other site 211586003129 homodimer interface [polypeptide binding]; other site 211586003130 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 211586003131 G-X-X-G motif; other site 211586003132 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 211586003133 G-X-X-G motif; other site 211586003134 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 211586003135 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 211586003136 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 211586003137 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 211586003138 translation initiation factor IF-2; Validated; Region: infB; PRK05306 211586003139 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 211586003140 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 211586003141 G1 box; other site 211586003142 putative GEF interaction site [polypeptide binding]; other site 211586003143 GTP/Mg2+ binding site [chemical binding]; other site 211586003144 Switch I region; other site 211586003145 G2 box; other site 211586003146 G3 box; other site 211586003147 Switch II region; other site 211586003148 G4 box; other site 211586003149 G5 box; other site 211586003150 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 211586003151 Translation-initiation factor 2; Region: IF-2; pfam11987 211586003152 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 211586003153 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 211586003154 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 211586003155 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 211586003156 RNA binding site [nucleotide binding]; other site 211586003157 active site 211586003158 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 211586003159 S15 leader 211586003160 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 211586003161 16S/18S rRNA binding site [nucleotide binding]; other site 211586003162 S13e-L30e interaction site [polypeptide binding]; other site 211586003163 25S rRNA binding site [nucleotide binding]; other site 211586003164 biofilm formation regulator HmsP; Provisional; Region: PRK11829 211586003165 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586003166 metal binding site [ion binding]; metal-binding site 211586003167 active site 211586003168 I-site; other site 211586003169 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586003170 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 211586003171 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 211586003172 RNase E interface [polypeptide binding]; other site 211586003173 trimer interface [polypeptide binding]; other site 211586003174 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 211586003175 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 211586003176 RNase E interface [polypeptide binding]; other site 211586003177 trimer interface [polypeptide binding]; other site 211586003178 active site 211586003179 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 211586003180 putative nucleic acid binding region [nucleotide binding]; other site 211586003181 G-X-X-G motif; other site 211586003182 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 211586003183 RNA binding site [nucleotide binding]; other site 211586003184 domain interface; other site 211586003185 lipoprotein NlpI; Provisional; Region: PRK11189 211586003186 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586003187 TPR motif; other site 211586003188 binding surface 211586003189 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 211586003190 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 211586003191 G1 box; other site 211586003192 putative GEF interaction site [polypeptide binding]; other site 211586003193 GTP/Mg2+ binding site [chemical binding]; other site 211586003194 Switch I region; other site 211586003195 G2 box; other site 211586003196 G3 box; other site 211586003197 Switch II region; other site 211586003198 G4 box; other site 211586003199 G5 box; other site 211586003200 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 211586003201 Elongation Factor G, domain II; Region: EFG_II; pfam14492 211586003202 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 211586003203 active site 211586003204 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 211586003205 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 211586003206 Nucleoside recognition; Region: Gate; pfam07670 211586003207 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 211586003208 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 211586003209 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 211586003210 intersubunit interface [polypeptide binding]; other site 211586003211 active site 211586003212 catalytic residue [active] 211586003213 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 211586003214 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 211586003215 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 211586003216 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 211586003217 phosphopentomutase; Provisional; Region: PRK05362 211586003218 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 211586003219 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 211586003220 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 211586003221 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211586003222 motif II; other site 211586003223 Serine hydrolase (FSH1); Region: FSH1; pfam03959 211586003224 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 211586003225 PilZ domain; Region: PilZ; pfam07238 211586003226 PilZ domain; Region: PilZ; pfam07238 211586003227 DNA repair protein RadA; Provisional; Region: PRK11823 211586003228 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 211586003229 Walker A motif/ATP binding site; other site 211586003230 ATP binding site [chemical binding]; other site 211586003231 Walker B motif; other site 211586003232 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 211586003233 PilZ domain; Region: PilZ; pfam07238 211586003234 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 211586003235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586003236 active site 211586003237 phosphorylation site [posttranslational modification] 211586003238 intermolecular recognition site; other site 211586003239 dimerization interface [polypeptide binding]; other site 211586003240 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211586003241 DNA binding site [nucleotide binding] 211586003242 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 211586003243 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 211586003244 putative ligand binding site [chemical binding]; other site 211586003245 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 211586003246 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586003247 dimerization interface [polypeptide binding]; other site 211586003248 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586003249 dimer interface [polypeptide binding]; other site 211586003250 phosphorylation site [posttranslational modification] 211586003251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586003252 ATP binding site [chemical binding]; other site 211586003253 Mg2+ binding site [ion binding]; other site 211586003254 G-X-G motif; other site 211586003255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586003256 active site 211586003257 phosphorylation site [posttranslational modification] 211586003258 intermolecular recognition site; other site 211586003259 dimerization interface [polypeptide binding]; other site 211586003260 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 211586003261 putative binding surface; other site 211586003262 active site 211586003263 chaperone protein TorD; Validated; Region: torD; PRK04976 211586003264 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 211586003265 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 211586003266 molybdopterin cofactor binding site [chemical binding]; other site 211586003267 substrate binding site [chemical binding]; other site 211586003268 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 211586003269 molybdopterin cofactor binding site; other site 211586003270 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 211586003271 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 211586003272 trimethylamine N-oxide reductase system, TorE protein; Region: TMAO_torE; TIGR02972 211586003273 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 211586003274 Sulfate transporter family; Region: Sulfate_transp; cl19250 211586003275 FOG: CBS domain [General function prediction only]; Region: COG0517 211586003276 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_24; cd04637 211586003277 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 211586003278 putative acyl-acceptor binding pocket; other site 211586003279 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 211586003280 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 211586003281 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 211586003282 putative active site [active] 211586003283 putative metal binding site [ion binding]; other site 211586003284 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586003285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 211586003286 Nucleoside recognition; Region: Gate; pfam07670 211586003287 putative protease; Provisional; Region: PRK15447 211586003288 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 211586003289 SCP-2 sterol transfer family; Region: SCP2; cl01225 211586003290 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 211586003291 putative protease; Provisional; Region: PRK15452 211586003292 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 211586003293 HDOD domain; Region: HDOD; pfam08668 211586003294 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586003295 metal binding site [ion binding]; metal-binding site 211586003296 active site 211586003297 I-site; other site 211586003298 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586003299 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 211586003300 active site 211586003301 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 211586003302 GDP-binding site [chemical binding]; other site 211586003303 ACT binding site; other site 211586003304 IMP binding site; other site 211586003305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586003306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586003307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 211586003308 dimerization interface [polypeptide binding]; other site 211586003309 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211586003310 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211586003311 substrate binding pocket [chemical binding]; other site 211586003312 membrane-bound complex binding site; other site 211586003313 hinge residues; other site 211586003314 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 211586003315 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 211586003316 active site residue [active] 211586003317 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 211586003318 active site residue [active] 211586003319 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 211586003320 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 211586003321 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 211586003322 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 211586003323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211586003324 non-specific DNA binding site [nucleotide binding]; other site 211586003325 salt bridge; other site 211586003326 sequence-specific DNA binding site [nucleotide binding]; other site 211586003327 Cupin domain; Region: Cupin_2; pfam07883 211586003328 Peptidase C26; Region: Peptidase_C26; pfam07722 211586003329 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 211586003330 catalytic triad [active] 211586003331 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 211586003332 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 211586003333 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586003334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586003335 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 211586003336 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 211586003337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211586003338 Walker A/P-loop; other site 211586003339 ATP binding site [chemical binding]; other site 211586003340 Q-loop/lid; other site 211586003341 ABC transporter signature motif; other site 211586003342 Walker B; other site 211586003343 D-loop; other site 211586003344 H-loop/switch region; other site 211586003345 TOBE domain; Region: TOBE_2; pfam08402 211586003346 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 211586003347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211586003348 dimer interface [polypeptide binding]; other site 211586003349 conserved gate region; other site 211586003350 putative PBP binding loops; other site 211586003351 ABC-ATPase subunit interface; other site 211586003352 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 211586003353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211586003354 dimer interface [polypeptide binding]; other site 211586003355 conserved gate region; other site 211586003356 putative PBP binding loops; other site 211586003357 ABC-ATPase subunit interface; other site 211586003358 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 211586003359 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 211586003360 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 211586003361 tetramerization interface [polypeptide binding]; other site 211586003362 NAD(P) binding site [chemical binding]; other site 211586003363 catalytic residues [active] 211586003364 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 211586003365 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 211586003366 inhibitor-cofactor binding pocket; inhibition site 211586003367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586003368 catalytic residue [active] 211586003369 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 211586003370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586003371 putative substrate translocation pore; other site 211586003372 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586003373 dimerization interface [polypeptide binding]; other site 211586003374 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 211586003375 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 211586003376 dimer interface [polypeptide binding]; other site 211586003377 putative CheW interface [polypeptide binding]; other site 211586003378 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 211586003379 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 211586003380 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 211586003381 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 211586003382 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 211586003383 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 211586003384 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 211586003385 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 211586003386 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 211586003387 DNA binding residues [nucleotide binding] 211586003388 DNA primase; Validated; Region: dnaG; PRK05667 211586003389 CHC2 zinc finger; Region: zf-CHC2; pfam01807 211586003390 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 211586003391 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 211586003392 active site 211586003393 metal binding site [ion binding]; metal-binding site 211586003394 interdomain interaction site; other site 211586003395 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 211586003396 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 211586003397 Yqey-like protein; Region: YqeY; pfam09424 211586003398 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 211586003399 UGMP family protein; Validated; Region: PRK09604 211586003400 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 211586003401 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 211586003402 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 211586003403 homooctamer interface [polypeptide binding]; other site 211586003404 active site 211586003405 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 211586003406 catalytic center binding site [active] 211586003407 ATP binding site [chemical binding]; other site 211586003408 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 211586003409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 211586003410 Lipoprotein leucine-zipper; Region: LPP; cl11539 211586003411 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 211586003412 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 211586003413 active site 211586003414 NTP binding site [chemical binding]; other site 211586003415 metal binding triad [ion binding]; metal-binding site 211586003416 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 211586003417 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211586003418 Zn2+ binding site [ion binding]; other site 211586003419 Mg2+ binding site [ion binding]; other site 211586003420 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 211586003421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586003422 Walker A motif; other site 211586003423 ATP binding site [chemical binding]; other site 211586003424 Walker B motif; other site 211586003425 arginine finger; other site 211586003426 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 211586003427 Alcohol dehydrogenase-like; Region: PLN02740 211586003428 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 211586003429 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 211586003430 inhibitor-cofactor binding pocket; inhibition site 211586003431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586003432 catalytic residue [active] 211586003433 aspartate carbamoyltransferase; Provisional; Region: PRK08192 211586003434 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 211586003435 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 211586003436 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 211586003437 Cl- selectivity filter; other site 211586003438 Cl- binding residues [ion binding]; other site 211586003439 pore gating glutamate residue; other site 211586003440 dimer interface [polypeptide binding]; other site 211586003441 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 211586003442 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 211586003443 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 211586003444 amphipathic channel; other site 211586003445 Asn-Pro-Ala signature motifs; other site 211586003446 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 211586003447 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 211586003448 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 211586003449 Class I aldolases; Region: Aldolase_Class_I; cl17187 211586003450 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 211586003451 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 211586003452 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211586003453 DNA binding site [nucleotide binding] 211586003454 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 211586003455 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 211586003456 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 211586003457 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 211586003458 putative peptidase; Provisional; Region: PRK11649 211586003459 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 211586003460 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 211586003461 Peptidase family M23; Region: Peptidase_M23; pfam01551 211586003462 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 211586003463 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 211586003464 active site 211586003465 HIGH motif; other site 211586003466 dimer interface [polypeptide binding]; other site 211586003467 KMSKS motif; other site 211586003468 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211586003469 RNA binding surface [nucleotide binding]; other site 211586003470 SnoaL-like domain; Region: SnoaL_2; pfam12680 211586003471 Predicted membrane protein [Function unknown]; Region: COG2860 211586003472 UPF0126 domain; Region: UPF0126; pfam03458 211586003473 UPF0126 domain; Region: UPF0126; pfam03458 211586003474 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 211586003475 CobD/Cbib protein; Region: CobD_Cbib; cl00561 211586003476 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 211586003477 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 211586003478 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 211586003479 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 211586003480 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 211586003481 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 211586003482 active site 211586003483 dimer interface [polypeptide binding]; other site 211586003484 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 211586003485 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 211586003486 active site 211586003487 FMN binding site [chemical binding]; other site 211586003488 substrate binding site [chemical binding]; other site 211586003489 3Fe-4S cluster binding site [ion binding]; other site 211586003490 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 211586003491 domain interface; other site 211586003492 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 211586003493 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211586003494 FeS/SAM binding site; other site 211586003495 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 211586003496 putative binding surface; other site 211586003497 active site 211586003498 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586003499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586003500 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 211586003501 dimerization interface [polypeptide binding]; other site 211586003502 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 211586003503 cyclase homology domain; Region: CHD; cd07302 211586003504 nucleotidyl binding site; other site 211586003505 metal binding site [ion binding]; metal-binding site 211586003506 dimer interface [polypeptide binding]; other site 211586003507 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 211586003508 putative DNA-binding cleft [nucleotide binding]; other site 211586003509 putative DNA clevage site; other site 211586003510 molecular lever; other site 211586003511 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 211586003512 putative active site [active] 211586003513 Ap4A binding site [chemical binding]; other site 211586003514 nudix motif; other site 211586003515 putative metal binding site [ion binding]; other site 211586003516 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 211586003517 GAF domain; Region: GAF; pfam01590 211586003518 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 211586003519 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 211586003520 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 211586003521 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 211586003522 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 211586003523 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 211586003524 dimerization interface [polypeptide binding]; other site 211586003525 active site 211586003526 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 211586003527 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 211586003528 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586003529 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 211586003530 dimerization interface [polypeptide binding]; other site 211586003531 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 211586003532 L-aspartate oxidase; Provisional; Region: PRK09077 211586003533 L-aspartate oxidase; Provisional; Region: PRK06175 211586003534 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 211586003535 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 211586003536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 211586003537 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 211586003538 DNA binding residues [nucleotide binding] 211586003539 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 211586003540 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 211586003541 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 211586003542 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 211586003543 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 211586003544 GTP-binding protein LepA; Provisional; Region: PRK05433 211586003545 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 211586003546 G1 box; other site 211586003547 putative GEF interaction site [polypeptide binding]; other site 211586003548 GTP/Mg2+ binding site [chemical binding]; other site 211586003549 Switch I region; other site 211586003550 G2 box; other site 211586003551 G3 box; other site 211586003552 Switch II region; other site 211586003553 G4 box; other site 211586003554 G5 box; other site 211586003555 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 211586003556 Elongation Factor G, domain II; Region: EFG_II; pfam14492 211586003557 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 211586003558 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 211586003559 signal peptidase I; Provisional; Region: PRK10861 211586003560 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 211586003561 Catalytic site [active] 211586003562 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 211586003563 ribonuclease III; Reviewed; Region: rnc; PRK00102 211586003564 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 211586003565 dimerization interface [polypeptide binding]; other site 211586003566 active site 211586003567 metal binding site [ion binding]; metal-binding site 211586003568 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 211586003569 dsRNA binding site [nucleotide binding]; other site 211586003570 GTPase Era; Reviewed; Region: era; PRK00089 211586003571 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 211586003572 G1 box; other site 211586003573 GTP/Mg2+ binding site [chemical binding]; other site 211586003574 Switch I region; other site 211586003575 G2 box; other site 211586003576 Switch II region; other site 211586003577 G3 box; other site 211586003578 G4 box; other site 211586003579 G5 box; other site 211586003580 KH domain; Region: KH_2; pfam07650 211586003581 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 211586003582 Recombination protein O N terminal; Region: RecO_N; pfam11967 211586003583 Recombination protein O C terminal; Region: RecO_C; pfam02565 211586003584 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 211586003585 active site 211586003586 hydrophilic channel; other site 211586003587 dimerization interface [polypeptide binding]; other site 211586003588 catalytic residues [active] 211586003589 active site lid [active] 211586003590 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 211586003591 Protein of unknown function (DUF962); Region: DUF962; cl01879 211586003592 hypothetical protein; Provisional; Region: PRK11573 211586003593 Domain of unknown function DUF21; Region: DUF21; pfam01595 211586003594 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 211586003595 Transporter associated domain; Region: CorC_HlyC; smart01091 211586003596 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 211586003597 signal recognition particle protein; Provisional; Region: PRK10867 211586003598 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 211586003599 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 211586003600 P loop; other site 211586003601 GTP binding site [chemical binding]; other site 211586003602 Signal peptide binding domain; Region: SRP_SPB; pfam02978 211586003603 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 211586003604 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 211586003605 RimM N-terminal domain; Region: RimM; pfam01782 211586003606 PRC-barrel domain; Region: PRC; pfam05239 211586003607 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 211586003608 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 211586003609 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 211586003610 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 211586003611 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 211586003612 prephenate dehydrogenase; Validated; Region: PRK08507 211586003613 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 211586003614 cubane metal cluster [ion binding]; other site 211586003615 hybrid metal cluster; other site 211586003616 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 211586003617 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 211586003618 FAD binding pocket [chemical binding]; other site 211586003619 FAD binding motif [chemical binding]; other site 211586003620 phosphate binding motif [ion binding]; other site 211586003621 beta-alpha-beta structure motif; other site 211586003622 NAD binding pocket [chemical binding]; other site 211586003623 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 211586003624 catalytic loop [active] 211586003625 iron binding site [ion binding]; other site 211586003626 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 211586003627 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 211586003628 Chorismate mutase type II; Region: CM_2; cl00693 211586003629 Prephenate dehydratase; Region: PDT; pfam00800 211586003630 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 211586003631 putative L-Phe binding site [chemical binding]; other site 211586003632 DAHP synthetase I family; Region: DAHP_synth_1; cl17225 211586003633 multifunctional aminopeptidase A; Provisional; Region: PRK00913 211586003634 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 211586003635 interface (dimer of trimers) [polypeptide binding]; other site 211586003636 Substrate-binding/catalytic site; other site 211586003637 Zn-binding sites [ion binding]; other site 211586003638 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; cl12074 211586003639 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 211586003640 RDD family; Region: RDD; pfam06271 211586003641 Protein of unknown function (DUF2960); Region: DUF2960; pfam11173 211586003642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3169 211586003643 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 211586003644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586003645 Coenzyme A binding pocket [chemical binding]; other site 211586003646 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 211586003647 active site 211586003648 Zn binding site [ion binding]; other site 211586003649 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 211586003650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 211586003651 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 211586003652 intracellular protease, PfpI family; Region: PfpI; TIGR01382 211586003653 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 211586003654 conserved cys residue [active] 211586003655 Ribbon-helix-helix domain; Region: RHH_4; cl01775 211586003656 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 211586003657 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 211586003658 putative catalytic residues [active] 211586003659 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 211586003660 DEAD-like helicases superfamily; Region: DEXDc; smart00487 211586003661 ATP binding site [chemical binding]; other site 211586003662 Mg++ binding site [ion binding]; other site 211586003663 motif III; other site 211586003664 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586003665 nucleotide binding region [chemical binding]; other site 211586003666 ATP-binding site [chemical binding]; other site 211586003667 PAS domain; Region: PAS_9; pfam13426 211586003668 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586003669 putative active site [active] 211586003670 heme pocket [chemical binding]; other site 211586003671 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 211586003672 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 211586003673 dimer interface [polypeptide binding]; other site 211586003674 putative CheW interface [polypeptide binding]; other site 211586003675 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211586003676 Zn2+ binding site [ion binding]; other site 211586003677 Mg2+ binding site [ion binding]; other site 211586003678 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 211586003679 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 211586003680 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 211586003681 active site 211586003682 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 211586003683 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 211586003684 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 211586003685 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 211586003686 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 211586003687 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 211586003688 HPP family; Region: HPP; pfam04982 211586003689 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 211586003690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211586003691 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 211586003692 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 211586003693 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 211586003694 Predicted membrane protein [Function unknown]; Region: COG2311 211586003695 Protein of unknown function (DUF418); Region: DUF418; cl12135 211586003696 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 211586003697 nucleoside/Zn binding site; other site 211586003698 dimer interface [polypeptide binding]; other site 211586003699 catalytic motif [active] 211586003700 Domain of unknown function (DUF368); Region: DUF368; pfam04018 211586003701 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 211586003702 Death Domain Superfamily of protein-protein interaction domains; Region: DD; cl14633 211586003703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 211586003704 YheO-like PAS domain; Region: PAS_6; pfam08348 211586003705 HTH domain; Region: HTH_22; pfam13309 211586003706 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 211586003707 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 211586003708 homotrimer interaction site [polypeptide binding]; other site 211586003709 putative active site [active] 211586003710 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 211586003711 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 211586003712 MerT mercuric transport protein; Region: MerT; cl03578 211586003713 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 211586003714 metal-binding site [ion binding] 211586003715 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 211586003716 PLD-like domain; Region: PLDc_2; pfam13091 211586003717 putative active site [active] 211586003718 catalytic site [active] 211586003719 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 211586003720 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211586003721 ATP binding site [chemical binding]; other site 211586003722 putative Mg++ binding site [ion binding]; other site 211586003723 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586003724 nucleotide binding region [chemical binding]; other site 211586003725 ATP-binding site [chemical binding]; other site 211586003726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586003727 S-adenosylmethionine binding site [chemical binding]; other site 211586003728 Cupin domain; Region: Cupin_2; cl17218 211586003729 Porin subfamily; Region: Porin_2; pfam02530 211586003730 Phosphate-selective porin O and P; Region: Porin_O_P; cl19535 211586003731 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 211586003732 L-aspartate oxidase; Provisional; Region: PRK06175 211586003733 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 211586003734 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 211586003735 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211586003736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586003737 active site 211586003738 phosphorylation site [posttranslational modification] 211586003739 intermolecular recognition site; other site 211586003740 dimerization interface [polypeptide binding]; other site 211586003741 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 211586003742 DNA binding residues [nucleotide binding] 211586003743 dimerization interface [polypeptide binding]; other site 211586003744 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 211586003745 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 211586003746 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211586003747 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586003748 dimer interface [polypeptide binding]; other site 211586003749 phosphorylation site [posttranslational modification] 211586003750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586003751 ATP binding site [chemical binding]; other site 211586003752 Mg2+ binding site [ion binding]; other site 211586003753 G-X-G motif; other site 211586003754 ApbE family; Region: ApbE; pfam02424 211586003755 FMN-binding domain; Region: FMN_bind; pfam04205 211586003756 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 211586003757 eyelet of channel; other site 211586003758 trimer interface [polypeptide binding]; other site 211586003759 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 211586003760 heme-binding residues [chemical binding]; other site 211586003761 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 211586003762 L-aspartate oxidase; Provisional; Region: PRK06175 211586003763 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 211586003764 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586003765 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 211586003766 dimerization interface [polypeptide binding]; other site 211586003767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 211586003768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 211586003769 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 211586003770 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 211586003771 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 211586003772 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 211586003773 Protein of unknown function (DUF3374); Region: DUF3374; pfam11854 211586003774 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 211586003775 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 211586003776 putative [Fe4-S4] binding site [ion binding]; other site 211586003777 putative molybdopterin cofactor binding site [chemical binding]; other site 211586003778 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 211586003779 putative molybdopterin cofactor binding site; other site 211586003780 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 211586003781 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 211586003782 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 211586003783 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 211586003784 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 211586003785 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586003786 dimerization interface [polypeptide binding]; other site 211586003787 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 211586003788 dimer interface [polypeptide binding]; other site 211586003789 putative CheW interface [polypeptide binding]; other site 211586003790 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 211586003791 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 211586003792 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586003793 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586003794 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 211586003795 active site 211586003796 NTP binding site [chemical binding]; other site 211586003797 metal binding triad [ion binding]; metal-binding site 211586003798 antibiotic binding site [chemical binding]; other site 211586003799 Protein of unknown function DUF86; Region: DUF86; pfam01934 211586003800 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 211586003801 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 211586003802 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 211586003803 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 211586003804 Predicted transcriptional regulator [Transcription]; Region: COG3905 211586003805 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 211586003806 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 211586003807 Int/Topo IB signature motif; other site 211586003808 Protein of unknown function (DUF2787); Region: DUF2787; pfam10980 211586003809 Protein of unknown function (DUF2787); Region: DUF2787; pfam10980 211586003810 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 211586003811 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 211586003812 MPN+ (JAMM) motif; other site 211586003813 Zinc-binding site [ion binding]; other site 211586003814 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 211586003815 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 211586003816 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 211586003817 Methyltransferase domain; Region: Methyltransf_26; pfam13659 211586003818 Predicted ATPase [General function prediction only]; Region: COG4637 211586003819 ABC transporter signature motif; other site 211586003820 AAA domain; Region: AAA_21; pfam13304 211586003821 Walker B; other site 211586003822 D-loop; other site 211586003823 H-loop/switch region; other site 211586003824 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 211586003825 Nuclease-related domain; Region: NERD; pfam08378 211586003826 Catalytic domain of Protein Kinases; Region: PKc; cd00180 211586003827 active site 211586003828 ATP binding site [chemical binding]; other site 211586003829 substrate binding site [chemical binding]; other site 211586003830 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 211586003831 substrate binding site [chemical binding]; other site 211586003832 activation loop (A-loop); other site 211586003833 activation loop (A-loop); other site 211586003834 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 211586003835 Catalytic domain of Protein Kinases; Region: PKc; cd00180 211586003836 active site 211586003837 ATP binding site [chemical binding]; other site 211586003838 substrate binding site [chemical binding]; other site 211586003839 activation loop (A-loop); other site 211586003840 Transposase; Region: HTH_Tnp_1; pfam01527 211586003841 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586003842 putative transposase OrfB; Reviewed; Region: PHA02517 211586003843 HTH-like domain; Region: HTH_21; pfam13276 211586003844 Integrase core domain; Region: rve; pfam00665 211586003845 Integrase core domain; Region: rve_2; pfam13333 211586003846 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 211586003847 ADP-ribose binding site [chemical binding]; other site 211586003848 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 211586003849 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211586003850 non-specific DNA binding site [nucleotide binding]; other site 211586003851 salt bridge; other site 211586003852 sequence-specific DNA binding site [nucleotide binding]; other site 211586003853 integrase; Provisional; Region: PRK09692 211586003854 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 211586003855 active site 211586003856 Int/Topo IB signature motif; other site 211586003857 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 211586003858 SmpB-tmRNA interface; other site 211586003859 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 211586003860 putative coenzyme Q binding site [chemical binding]; other site 211586003861 hypothetical protein; Validated; Region: PRK01777 211586003862 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 211586003863 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 211586003864 active site 211586003865 SAM binding site [chemical binding]; other site 211586003866 homodimer interface [polypeptide binding]; other site 211586003867 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 211586003868 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586003869 metal binding site [ion binding]; metal-binding site 211586003870 active site 211586003871 I-site; other site 211586003872 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 211586003873 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 211586003874 TrkA-N domain; Region: TrkA_N; pfam02254 211586003875 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 211586003876 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 211586003877 N-terminal plug; other site 211586003878 ligand-binding site [chemical binding]; other site 211586003879 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 211586003880 active site 211586003881 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 211586003882 tetramer interface [polypeptide binding]; other site 211586003883 active site 211586003884 Mg2+/Mn2+ binding site [ion binding]; other site 211586003885 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 211586003886 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 211586003887 dimer interface [polypeptide binding]; other site 211586003888 active site 211586003889 metal binding site [ion binding]; metal-binding site 211586003890 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 211586003891 active site 211586003892 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 211586003893 glycogen branching enzyme; Provisional; Region: PRK05402 211586003894 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 211586003895 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 211586003896 active site 211586003897 catalytic site [active] 211586003898 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 211586003899 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 211586003900 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 211586003901 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 211586003902 active site 211586003903 catalytic site [active] 211586003904 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 211586003905 homodimer interface [polypeptide binding]; other site 211586003906 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 211586003907 active site pocket [active] 211586003908 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 211586003909 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 211586003910 ligand binding site; other site 211586003911 oligomer interface; other site 211586003912 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 211586003913 dimer interface [polypeptide binding]; other site 211586003914 N-terminal domain interface [polypeptide binding]; other site 211586003915 sulfate 1 binding site; other site 211586003916 glycogen/starch synthase, ADP-glucose type; Region: glgA; TIGR02095 211586003917 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 211586003918 ADP-binding pocket [chemical binding]; other site 211586003919 homodimer interface [polypeptide binding]; other site 211586003920 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 211586003921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586003922 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 211586003923 putative active site [active] 211586003924 heme pocket [chemical binding]; other site 211586003925 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586003926 putative active site [active] 211586003927 heme pocket [chemical binding]; other site 211586003928 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586003929 PAS domain; Region: PAS_9; pfam13426 211586003930 putative active site [active] 211586003931 heme pocket [chemical binding]; other site 211586003932 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586003933 metal binding site [ion binding]; metal-binding site 211586003934 active site 211586003935 I-site; other site 211586003936 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586003937 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 211586003938 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 211586003939 ATP binding site [chemical binding]; other site 211586003940 Mg++ binding site [ion binding]; other site 211586003941 motif III; other site 211586003942 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586003943 nucleotide binding region [chemical binding]; other site 211586003944 ATP-binding site [chemical binding]; other site 211586003945 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 211586003946 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 211586003947 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 211586003948 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211586003949 substrate binding pocket [chemical binding]; other site 211586003950 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211586003951 membrane-bound complex binding site; other site 211586003952 hinge residues; other site 211586003953 Protein of unknown function (DUF3087); Region: DUF3087; pfam11286 211586003954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586003955 Major Facilitator Superfamily; Region: MFS_1; pfam07690 211586003956 putative substrate translocation pore; other site 211586003957 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 211586003958 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 211586003959 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 211586003960 dimer interface [polypeptide binding]; other site 211586003961 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 211586003962 dimer interface [polypeptide binding]; other site 211586003963 ligand binding site [chemical binding]; other site 211586003964 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 211586003965 Putative transposase; Region: Y2_Tnp; pfam04986 211586003966 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 211586003967 Transposase; Region: HTH_Tnp_1; pfam01527 211586003968 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586003969 putative transposase OrfB; Reviewed; Region: PHA02517 211586003970 HTH-like domain; Region: HTH_21; pfam13276 211586003971 Integrase core domain; Region: rve; pfam00665 211586003972 Integrase core domain; Region: rve_2; pfam13333 211586003973 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 211586003974 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 211586003975 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 211586003976 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 211586003977 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 211586003978 Cysteine-rich domain; Region: CCG; pfam02754 211586003979 Cysteine-rich domain; Region: CCG; pfam02754 211586003980 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 211586003981 FAD binding domain; Region: FAD_binding_4; pfam01565 211586003982 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 211586003983 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 211586003984 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 211586003985 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 211586003986 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 211586003987 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 211586003988 dimer interface [polypeptide binding]; other site 211586003989 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 211586003990 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 211586003991 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 211586003992 TPP-binding site; other site 211586003993 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 211586003994 PYR/PP interface [polypeptide binding]; other site 211586003995 dimer interface [polypeptide binding]; other site 211586003996 TPP binding site [chemical binding]; other site 211586003997 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 211586003998 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 211586003999 substrate binding pocket [chemical binding]; other site 211586004000 chain length determination region; other site 211586004001 substrate-Mg2+ binding site; other site 211586004002 catalytic residues [active] 211586004003 aspartate-rich region 1; other site 211586004004 active site lid residues [active] 211586004005 aspartate-rich region 2; other site 211586004006 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 211586004007 flagellar motor protein PomA; Reviewed; Region: PRK08990 211586004008 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 211586004009 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 211586004010 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 211586004011 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 211586004012 ligand binding site [chemical binding]; other site 211586004013 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 211586004014 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 211586004015 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 211586004016 Ligand Binding Site [chemical binding]; other site 211586004017 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 211586004018 active site residue [active] 211586004019 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 211586004020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586004021 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 211586004022 dimerization interface [polypeptide binding]; other site 211586004023 substrate binding pocket [chemical binding]; other site 211586004024 Putative lysophospholipase; Region: Hydrolase_4; cl19140 211586004025 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 211586004026 Protein of unknown function (DUF423); Region: DUF423; pfam04241 211586004027 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 211586004028 FtsJ-like methyltransferase; Region: FtsJ; cl17430 211586004029 isocitrate dehydrogenase; Provisional; Region: PRK08997 211586004030 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 211586004031 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 211586004032 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586004033 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 211586004034 flap endonuclease-like protein; Provisional; Region: PRK09482 211586004035 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 211586004036 active site 211586004037 metal binding site 1 [ion binding]; metal-binding site 211586004038 putative 5' ssDNA interaction site; other site 211586004039 metal binding site 3; metal-binding site 211586004040 metal binding site 2 [ion binding]; metal-binding site 211586004041 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 211586004042 putative DNA binding site [nucleotide binding]; other site 211586004043 putative metal binding site [ion binding]; other site 211586004044 Domain of unknown function (DUF4478); Region: DUF4478; pfam14793 211586004045 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 211586004046 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 211586004047 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586004048 metal binding site [ion binding]; metal-binding site 211586004049 active site 211586004050 I-site; other site 211586004051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586004052 binding surface 211586004053 TPR motif; other site 211586004054 Tetratricopeptide repeat; Region: TPR_12; pfam13424 211586004055 Tetratricopeptide repeat; Region: TPR_12; pfam13424 211586004056 recombination associated protein; Reviewed; Region: rdgC; PRK00321 211586004057 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 211586004058 trimer interface [polypeptide binding]; other site 211586004059 eyelet of channel; other site 211586004060 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 211586004061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586004062 active site 211586004063 phosphorylation site [posttranslational modification] 211586004064 intermolecular recognition site; other site 211586004065 dimerization interface [polypeptide binding]; other site 211586004066 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211586004067 DNA binding site [nucleotide binding] 211586004068 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 211586004069 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 211586004070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586004071 putative active site [active] 211586004072 heme pocket [chemical binding]; other site 211586004073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586004074 dimer interface [polypeptide binding]; other site 211586004075 phosphorylation site [posttranslational modification] 211586004076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586004077 ATP binding site [chemical binding]; other site 211586004078 Mg2+ binding site [ion binding]; other site 211586004079 G-X-G motif; other site 211586004080 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 211586004081 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 211586004082 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 211586004083 active site 211586004084 Zn binding site [ion binding]; other site 211586004085 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 211586004086 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 211586004087 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 211586004088 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 211586004089 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 211586004090 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 211586004091 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 211586004092 catalytic residues [active] 211586004093 dimer interface [polypeptide binding]; other site 211586004094 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 211586004095 MgtE intracellular N domain; Region: MgtE_N; smart00924 211586004096 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 211586004097 Divalent cation transporter; Region: MgtE; cl00786 211586004098 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 211586004099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586004100 Coenzyme A binding pocket [chemical binding]; other site 211586004101 YfaZ precursor; Region: YfaZ; pfam07437 211586004102 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 211586004103 EamA-like transporter family; Region: EamA; cl17759 211586004104 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 211586004105 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 211586004106 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586004107 metal binding site [ion binding]; metal-binding site 211586004108 active site 211586004109 I-site; other site 211586004110 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 211586004111 Uncharacterized conserved protein [Function unknown]; Region: COG3349 211586004112 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 211586004113 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 211586004114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586004115 S-adenosylmethionine binding site [chemical binding]; other site 211586004116 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 211586004117 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 211586004118 C-terminal domain interface [polypeptide binding]; other site 211586004119 GSH binding site (G-site) [chemical binding]; other site 211586004120 dimer interface [polypeptide binding]; other site 211586004121 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 211586004122 N-terminal domain interface [polypeptide binding]; other site 211586004123 putative dimer interface [polypeptide binding]; other site 211586004124 active site 211586004125 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 211586004126 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 211586004127 putative C-terminal domain interface [polypeptide binding]; other site 211586004128 putative GSH binding site (G-site) [chemical binding]; other site 211586004129 putative dimer interface [polypeptide binding]; other site 211586004130 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 211586004131 putative N-terminal domain interface [polypeptide binding]; other site 211586004132 putative dimer interface [polypeptide binding]; other site 211586004133 putative substrate binding pocket (H-site) [chemical binding]; other site 211586004134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 211586004135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211586004136 TIGR02453 family protein; Region: TIGR02453 211586004137 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 211586004138 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 211586004139 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 211586004140 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 211586004141 PhnA protein; Region: PhnA; pfam03831 211586004142 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 211586004143 Transcriptional regulators [Transcription]; Region: MarR; COG1846 211586004144 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 211586004145 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 211586004146 putative active site [active] 211586004147 Zn binding site [ion binding]; other site 211586004148 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 211586004149 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 211586004150 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 211586004151 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 211586004152 ligand binding site [chemical binding]; other site 211586004153 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 211586004154 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 211586004155 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 211586004156 FMN binding site [chemical binding]; other site 211586004157 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 211586004158 substrate binding site [chemical binding]; other site 211586004159 putative catalytic residue [active] 211586004160 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 211586004161 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 211586004162 active site 211586004163 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 211586004164 active site 211586004165 Salmonella-Shigella invasin protein C (IpaC_SipC); Region: IpaC_SipC; cl10712 211586004166 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 211586004167 active site 2 [active] 211586004168 dimer interface [polypeptide binding]; other site 211586004169 active site 1 [active] 211586004170 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 211586004171 active site 1 [active] 211586004172 dimer interface [polypeptide binding]; other site 211586004173 active site 2 [active] 211586004174 Acyl transferase domain; Region: Acyl_transf_1; cl08282 211586004175 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 211586004176 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 211586004177 active site 211586004178 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 211586004179 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 211586004180 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 211586004181 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 211586004182 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 211586004183 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 211586004184 putative NADP binding site [chemical binding]; other site 211586004185 active site 211586004186 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 211586004187 Winged helix-turn helix; Region: HTH_29; pfam13551 211586004188 Homeodomain-like domain; Region: HTH_23; pfam13384 211586004189 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 211586004190 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 211586004191 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 211586004192 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 211586004193 Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863 211586004194 Alkyl sulfatase C-terminal; Region: Alkyl_sulf_C; pfam14864 211586004195 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 211586004196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586004197 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 211586004198 putative substrate binding pocket [chemical binding]; other site 211586004199 putative dimerization interface [polypeptide binding]; other site 211586004200 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 211586004201 Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term; Region: QueF_N; pfam14819 211586004202 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 211586004203 SecY interacting protein Syd; Provisional; Region: PRK04968 211586004204 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; pfam10071 211586004205 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 211586004206 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 211586004207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586004208 Coenzyme A binding pocket [chemical binding]; other site 211586004209 Protein of unknown function (DUF962); Region: DUF962; pfam06127 211586004210 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586004211 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586004212 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 211586004213 Protein of unknown function (DUF3549); Region: DUF3549; pfam12069 211586004214 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 211586004215 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 211586004216 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 211586004217 probable active site [active] 211586004218 flavodoxin; Provisional; Region: PRK08105 211586004219 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 211586004220 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 211586004221 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 211586004222 active site turn [active] 211586004223 phosphorylation site [posttranslational modification] 211586004224 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 211586004225 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 211586004226 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 211586004227 putative active site [active] 211586004228 putative substrate binding site [chemical binding]; other site 211586004229 putative cosubstrate binding site; other site 211586004230 catalytic site [active] 211586004231 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 211586004232 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805 211586004233 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 211586004234 trimer interface [polypeptide binding]; other site 211586004235 active site 211586004236 substrate binding site [chemical binding]; other site 211586004237 CoA binding site [chemical binding]; other site 211586004238 PII uridylyl-transferase; Provisional; Region: PRK05007 211586004239 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 211586004240 metal binding triad; other site 211586004241 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 211586004242 HD domain; Region: HD; pfam01966 211586004243 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 211586004244 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 211586004245 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 211586004246 active site 211586004247 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 211586004248 rRNA interaction site [nucleotide binding]; other site 211586004249 S8 interaction site; other site 211586004250 putative laminin-1 binding site; other site 211586004251 elongation factor Ts; Provisional; Region: tsf; PRK09377 211586004252 UBA/TS-N domain; Region: UBA; pfam00627 211586004253 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 211586004254 putative nucleotide binding site [chemical binding]; other site 211586004255 uridine monophosphate binding site [chemical binding]; other site 211586004256 homohexameric interface [polypeptide binding]; other site 211586004257 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 211586004258 hinge region; other site 211586004259 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 211586004260 active site 211586004261 dimer interface [polypeptide binding]; other site 211586004262 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 211586004263 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 211586004264 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 211586004265 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 211586004266 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 211586004267 zinc metallopeptidase RseP; Provisional; Region: PRK10779 211586004268 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 211586004269 active site 211586004270 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 211586004271 protein binding site [polypeptide binding]; other site 211586004272 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 211586004273 protein binding site [polypeptide binding]; other site 211586004274 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 211586004275 putative substrate binding region [chemical binding]; other site 211586004276 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 211586004277 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 211586004278 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 211586004279 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 211586004280 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 211586004281 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 211586004282 Surface antigen; Region: Bac_surface_Ag; pfam01103 211586004283 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 211586004284 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 211586004285 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 211586004286 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 211586004287 trimer interface [polypeptide binding]; other site 211586004288 active site 211586004289 UDP-GlcNAc binding site [chemical binding]; other site 211586004290 lipid binding site [chemical binding]; lipid-binding site 211586004291 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 211586004292 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 211586004293 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 211586004294 active site 211586004295 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 211586004296 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 211586004297 AMP binding site [chemical binding]; other site 211586004298 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 211586004299 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 211586004300 RNA/DNA hybrid binding site [nucleotide binding]; other site 211586004301 active site 211586004302 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 211586004303 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 211586004304 putative active site [active] 211586004305 putative PHP Thumb interface [polypeptide binding]; other site 211586004306 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 211586004307 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 211586004308 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 211586004309 generic binding surface II; other site 211586004310 generic binding surface I; other site 211586004311 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 211586004312 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 211586004313 Ligand Binding Site [chemical binding]; other site 211586004314 TilS substrate binding domain; Region: TilS; pfam09179 211586004315 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 211586004316 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586004317 metal binding site [ion binding]; metal-binding site 211586004318 active site 211586004319 I-site; other site 211586004320 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 211586004321 putative cation:proton antiport protein; Provisional; Region: PRK10669 211586004322 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 211586004323 TrkA-N domain; Region: TrkA_N; pfam02254 211586004324 TrkA-C domain; Region: TrkA_C; pfam02080 211586004325 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 211586004326 DNA-binding site [nucleotide binding]; DNA binding site 211586004327 RNA-binding motif; other site 211586004328 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 211586004329 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211586004330 ATP binding site [chemical binding]; other site 211586004331 putative Mg++ binding site [ion binding]; other site 211586004332 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586004333 nucleotide binding region [chemical binding]; other site 211586004334 ATP-binding site [chemical binding]; other site 211586004335 putative hydrolase; Validated; Region: PRK09248 211586004336 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 211586004337 active site 211586004338 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 211586004339 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 211586004340 NADP binding site [chemical binding]; other site 211586004341 active site 211586004342 putative substrate binding site [chemical binding]; other site 211586004343 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 211586004344 active site 211586004345 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 211586004346 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 211586004347 nucleotide binding site [chemical binding]; other site 211586004348 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 211586004349 putative active site [active] 211586004350 Protein of unknown function (DUF2982); Region: DUF2982; pfam11201 211586004351 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 211586004352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586004353 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 211586004354 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 211586004355 dimerization interface [polypeptide binding]; other site 211586004356 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 211586004357 ferredoxin-type protein; Provisional; Region: PRK10194 211586004358 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 211586004359 4Fe-4S binding domain; Region: Fer4; pfam00037 211586004360 UDP-glucose 4-epimerase; Region: PLN02240 211586004361 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 211586004362 NAD binding site [chemical binding]; other site 211586004363 homodimer interface [polypeptide binding]; other site 211586004364 active site 211586004365 substrate binding site [chemical binding]; other site 211586004366 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 211586004367 active site 211586004368 tetramer interface; other site 211586004369 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 211586004370 cofactor binding site; other site 211586004371 metal binding site [ion binding]; metal-binding site 211586004372 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 211586004373 aromatic arch; other site 211586004374 DCoH dimer interaction site [polypeptide binding]; other site 211586004375 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 211586004376 DCoH tetramer interaction site [polypeptide binding]; other site 211586004377 substrate binding site [chemical binding]; other site 211586004378 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 211586004379 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 211586004380 PAS domain; Region: PAS; smart00091 211586004381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586004382 Walker A motif; other site 211586004383 ATP binding site [chemical binding]; other site 211586004384 Walker B motif; other site 211586004385 arginine finger; other site 211586004386 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 211586004387 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 211586004388 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 211586004389 maleylacetoacetate isomerase; Region: maiA; TIGR01262 211586004390 C-terminal domain interface [polypeptide binding]; other site 211586004391 GSH binding site (G-site) [chemical binding]; other site 211586004392 putative dimer interface [polypeptide binding]; other site 211586004393 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 211586004394 dimer interface [polypeptide binding]; other site 211586004395 N-terminal domain interface [polypeptide binding]; other site 211586004396 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 211586004397 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 211586004398 outer membrane protein W; Provisional; Region: PRK10959 211586004399 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 211586004400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 211586004401 NAD(P) binding site [chemical binding]; other site 211586004402 active site 211586004403 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 211586004404 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 211586004405 proposed active site lysine [active] 211586004406 conserved cys residue [active] 211586004407 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 211586004408 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 211586004409 dimer interface [polypeptide binding]; other site 211586004410 active site 211586004411 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 211586004412 tetrameric interface [polypeptide binding]; other site 211586004413 NAD binding site [chemical binding]; other site 211586004414 catalytic residues [active] 211586004415 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 211586004416 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 211586004417 active site 211586004418 enoyl-CoA hydratase; Provisional; Region: PRK09076 211586004419 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 211586004420 substrate binding site [chemical binding]; other site 211586004421 oxyanion hole (OAH) forming residues; other site 211586004422 trimer interface [polypeptide binding]; other site 211586004423 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 211586004424 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 211586004425 substrate binding site [chemical binding]; other site 211586004426 oxyanion hole (OAH) forming residues; other site 211586004427 trimer interface [polypeptide binding]; other site 211586004428 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 211586004429 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 211586004430 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 211586004431 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 211586004432 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 211586004433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 211586004434 NAD(P) binding site [chemical binding]; other site 211586004435 active site 211586004436 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 211586004437 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 211586004438 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 211586004439 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 211586004440 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 211586004441 DNA binding residues [nucleotide binding] 211586004442 dimer interface [polypeptide binding]; other site 211586004443 copper binding site [ion binding]; other site 211586004444 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 211586004445 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 211586004446 metal-binding site [ion binding] 211586004447 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 211586004448 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211586004449 motif II; other site 211586004450 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 211586004451 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 211586004452 ABC transporter; Region: ABC_tran_2; pfam12848 211586004453 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 211586004454 Lipocalin-like domain; Region: Lipocalin_2; cl19222 211586004455 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 211586004456 EamA-like transporter family; Region: EamA; pfam00892 211586004457 EamA-like transporter family; Region: EamA; pfam00892 211586004458 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 211586004459 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 211586004460 FAD binding domain; Region: FAD_binding_4; pfam01565 211586004461 Berberine and berberine like; Region: BBE; pfam08031 211586004462 PAS domain S-box; Region: sensory_box; TIGR00229 211586004463 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586004464 putative active site [active] 211586004465 heme pocket [chemical binding]; other site 211586004466 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586004467 metal binding site [ion binding]; metal-binding site 211586004468 active site 211586004469 I-site; other site 211586004470 Domain of unknown function (DUF1888); Region: DUF1888; pfam08985 211586004471 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211586004472 DNA binding site [nucleotide binding] 211586004473 AAA ATPase domain; Region: AAA_16; pfam13191 211586004474 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 211586004475 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 211586004476 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586004477 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 211586004478 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 211586004479 Walker A/P-loop; other site 211586004480 ATP binding site [chemical binding]; other site 211586004481 Q-loop/lid; other site 211586004482 ABC transporter signature motif; other site 211586004483 Walker B; other site 211586004484 D-loop; other site 211586004485 H-loop/switch region; other site 211586004486 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 211586004487 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 211586004488 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 211586004489 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 211586004490 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 211586004491 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 211586004492 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 211586004493 DNA binding site [nucleotide binding] 211586004494 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 211586004495 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 211586004496 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 211586004497 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 211586004498 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 211586004499 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 211586004500 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 211586004501 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 211586004502 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 211586004503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211586004504 ABC-ATPase subunit interface; other site 211586004505 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 211586004506 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 211586004507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211586004508 dimer interface [polypeptide binding]; other site 211586004509 conserved gate region; other site 211586004510 putative PBP binding loops; other site 211586004511 ABC-ATPase subunit interface; other site 211586004512 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 211586004513 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 211586004514 Walker A/P-loop; other site 211586004515 ATP binding site [chemical binding]; other site 211586004516 Q-loop/lid; other site 211586004517 ABC transporter signature motif; other site 211586004518 Walker B; other site 211586004519 D-loop; other site 211586004520 H-loop/switch region; other site 211586004521 transcriptional regulator PhoU; Provisional; Region: PRK11115 211586004522 PhoU domain; Region: PhoU; pfam01895 211586004523 PhoU domain; Region: PhoU; pfam01895 211586004524 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 211586004525 DNA-binding site [nucleotide binding]; DNA binding site 211586004526 RNA-binding motif; other site 211586004527 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 211586004528 dimer interface [polypeptide binding]; other site 211586004529 metal binding site [ion binding]; metal-binding site 211586004530 Protein of unknown function (DUF502); Region: DUF502; pfam04367 211586004531 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 211586004532 active site 211586004533 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 211586004534 Methyltransferase domain; Region: Methyltransf_32; pfam13679 211586004535 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 211586004536 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 211586004537 dimer interface [polypeptide binding]; other site 211586004538 active site 211586004539 CoA binding pocket [chemical binding]; other site 211586004540 haloalkane dehalogenase; Provisional; Region: PRK03592 211586004541 Putative lysophospholipase; Region: Hydrolase_4; cl19140 211586004542 peptide synthase; Provisional; Region: PRK09274 211586004543 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 211586004544 acyl-activating enzyme (AAE) consensus motif; other site 211586004545 AMP binding site [chemical binding]; other site 211586004546 active site 211586004547 CoA binding site [chemical binding]; other site 211586004548 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 211586004549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 211586004550 NAD(P) binding site [chemical binding]; other site 211586004551 active site 211586004552 Protein of unknown function (DUF3624); Region: DUF3624; pfam12292 211586004553 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 211586004554 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 211586004555 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 211586004556 Walker A/P-loop; other site 211586004557 ATP binding site [chemical binding]; other site 211586004558 Q-loop/lid; other site 211586004559 ABC transporter signature motif; other site 211586004560 Walker B; other site 211586004561 D-loop; other site 211586004562 H-loop/switch region; other site 211586004563 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 211586004564 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 211586004565 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 211586004566 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 211586004567 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 211586004568 Zn binding site [ion binding]; other site 211586004569 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 211586004570 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 211586004571 active site 211586004572 substrate binding site [chemical binding]; other site 211586004573 metal binding site [ion binding]; metal-binding site 211586004574 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 211586004575 Integron-associated effector binding protein; Region: Cass2; pfam14526 211586004576 Predicted transcriptional regulator [Transcription]; Region: COG2378 211586004577 HTH domain; Region: HTH_11; pfam08279 211586004578 WYL domain; Region: WYL; pfam13280 211586004579 Predicted membrane protein [Function unknown]; Region: COG4392 211586004580 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 211586004581 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 211586004582 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 211586004583 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 211586004584 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 211586004585 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 211586004586 trimer interface [polypeptide binding]; other site 211586004587 active site 211586004588 substrate binding site [chemical binding]; other site 211586004589 CoA binding site [chemical binding]; other site 211586004590 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 211586004591 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586004592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586004593 putative pyridoxal-dependent aspartate 1-decarboxylase; Region: NOD_PanD_pyr; TIGR03799 211586004594 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 211586004595 catalytic residue [active] 211586004596 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 211586004597 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 211586004598 fructuronate transporter; Provisional; Region: PRK10034; cl15264 211586004599 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 211586004600 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 211586004601 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 211586004602 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 211586004603 ligand binding site [chemical binding]; other site 211586004604 active site 211586004605 Protein of unknown function (DUF3374); Region: DUF3374; pfam11854 211586004606 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 211586004607 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 211586004608 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 211586004609 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 211586004610 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 211586004611 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 211586004612 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 211586004613 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 211586004614 heme-binding residues [chemical binding]; other site 211586004615 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 211586004616 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 211586004617 heme-binding residues [chemical binding]; other site 211586004618 decaheme-associated outer membrane protein, MtrB/PioB family; Region: OMP_MtrB_PioB; TIGR03509 211586004619 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 211586004620 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 211586004621 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 211586004622 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 211586004623 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 211586004624 FeoA domain; Region: FeoA; pfam04023 211586004625 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 211586004626 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 211586004627 G1 box; other site 211586004628 GTP/Mg2+ binding site [chemical binding]; other site 211586004629 Switch I region; other site 211586004630 G2 box; other site 211586004631 G3 box; other site 211586004632 Switch II region; other site 211586004633 G4 box; other site 211586004634 G5 box; other site 211586004635 Nucleoside recognition; Region: Gate; pfam07670 211586004636 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 211586004637 Nucleoside recognition; Region: Gate; pfam07670 211586004638 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 211586004639 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 211586004640 active site 211586004641 HIGH motif; other site 211586004642 KMSKS motif; other site 211586004643 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 211586004644 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 211586004645 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 211586004646 active site 211586004647 dinuclear metal binding site [ion binding]; other site 211586004648 dimerization interface [polypeptide binding]; other site 211586004649 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 211586004650 putative active site [active] 211586004651 putative metal binding site [ion binding]; other site 211586004652 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 211586004653 substrate binding site [chemical binding]; other site 211586004654 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 211586004655 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 211586004656 active site 211586004657 HIGH motif; other site 211586004658 KMSKS motif; other site 211586004659 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 211586004660 tRNA binding surface [nucleotide binding]; other site 211586004661 anticodon binding site; other site 211586004662 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 211586004663 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 211586004664 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 211586004665 homodimer interface [polypeptide binding]; other site 211586004666 NADP binding site [chemical binding]; other site 211586004667 substrate binding site [chemical binding]; other site 211586004668 trigger factor; Provisional; Region: tig; PRK01490 211586004669 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 211586004670 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 211586004671 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 211586004672 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 211586004673 oligomer interface [polypeptide binding]; other site 211586004674 active site residues [active] 211586004675 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 211586004676 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 211586004677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586004678 Walker A motif; other site 211586004679 ATP binding site [chemical binding]; other site 211586004680 Walker B motif; other site 211586004681 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 211586004682 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 211586004683 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 211586004684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586004685 Walker A motif; other site 211586004686 ATP binding site [chemical binding]; other site 211586004687 Walker B motif; other site 211586004688 arginine finger; other site 211586004689 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 211586004690 histone-like DNA-binding protein HU; Region: HU; cd13831 211586004691 dimer interface [polypeptide binding]; other site 211586004692 DNA binding site [nucleotide binding] 211586004693 periplasmic folding chaperone; Provisional; Region: PRK10788 211586004694 SurA N-terminal domain; Region: SurA_N_3; cl07813 211586004695 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 211586004696 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 211586004697 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 211586004698 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 211586004699 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 211586004700 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 211586004701 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167 211586004702 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 211586004703 Walker A/P-loop; other site 211586004704 ATP binding site [chemical binding]; other site 211586004705 Q-loop/lid; other site 211586004706 ABC transporter signature motif; other site 211586004707 Walker B; other site 211586004708 D-loop; other site 211586004709 H-loop/switch region; other site 211586004710 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 211586004711 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170 211586004712 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 211586004713 Walker A/P-loop; other site 211586004714 ATP binding site [chemical binding]; other site 211586004715 Q-loop/lid; other site 211586004716 ABC transporter signature motif; other site 211586004717 Walker B; other site 211586004718 D-loop; other site 211586004719 H-loop/switch region; other site 211586004720 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 211586004721 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 211586004722 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 211586004723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211586004724 dimer interface [polypeptide binding]; other site 211586004725 conserved gate region; other site 211586004726 putative PBP binding loops; other site 211586004727 ABC-ATPase subunit interface; other site 211586004728 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 211586004729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211586004730 dimer interface [polypeptide binding]; other site 211586004731 conserved gate region; other site 211586004732 putative PBP binding loops; other site 211586004733 ABC-ATPase subunit interface; other site 211586004734 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 211586004735 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 211586004736 peptide binding site [polypeptide binding]; other site 211586004737 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 211586004738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586004739 Walker A motif; other site 211586004740 ATP binding site [chemical binding]; other site 211586004741 Walker B motif; other site 211586004742 arginine finger; other site 211586004743 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 211586004744 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 211586004745 phage shock protein A; Region: phageshock_pspA; TIGR02977 211586004746 phage shock protein B; Provisional; Region: pspB; PRK09458 211586004747 PspC domain; Region: PspC; cl00864 211586004748 phage shock protein C; Region: phageshock_pspC; TIGR02978 211586004749 YcjX-like family, DUF463; Region: DUF463; pfam04317 211586004750 hypothetical protein; Provisional; Region: PRK05415 211586004751 Predicted membrane protein [Function unknown]; Region: COG3768 211586004752 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 211586004753 homodimer interface [polypeptide binding]; other site 211586004754 substrate-cofactor binding pocket; other site 211586004755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586004756 catalytic residue [active] 211586004757 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 211586004758 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 211586004759 Late competence development protein ComFB; Region: ComFB; pfam10719 211586004760 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 211586004761 putative active site [active] 211586004762 Zn binding site [ion binding]; other site 211586004763 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829 211586004764 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 211586004765 hypothetical protein; Provisional; Region: PRK10621 211586004766 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 211586004767 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 211586004768 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 211586004769 DNA polymerase II; Reviewed; Region: PRK05762 211586004770 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 211586004771 active site 211586004772 catalytic site [active] 211586004773 substrate binding site [chemical binding]; other site 211586004774 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 211586004775 active site 211586004776 metal-binding site 211586004777 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 211586004778 trimer interface [polypeptide binding]; other site 211586004779 eyelet of channel; other site 211586004780 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 211586004781 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 211586004782 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 211586004783 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 211586004784 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 211586004785 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 211586004786 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 211586004787 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 211586004788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586004789 TPR motif; other site 211586004790 binding surface 211586004791 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586004792 binding surface 211586004793 TPR motif; other site 211586004794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586004795 TPR motif; other site 211586004796 binding surface 211586004797 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 211586004798 metal binding site [ion binding]; metal-binding site 211586004799 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 211586004800 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 211586004801 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 211586004802 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586004803 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 211586004804 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 211586004805 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 211586004806 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211586004807 RNA binding surface [nucleotide binding]; other site 211586004808 Regulator of ribonuclease activity B; Region: RraB; pfam06877 211586004809 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 211586004810 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211586004811 substrate binding pocket [chemical binding]; other site 211586004812 membrane-bound complex binding site; other site 211586004813 hinge residues; other site 211586004814 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 211586004815 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 211586004816 Lamin Tail Domain; Region: LTD; pfam00932 211586004817 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 211586004818 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 211586004819 generic binding surface II; other site 211586004820 generic binding surface I; other site 211586004821 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 211586004822 putative active site [active] 211586004823 putative catalytic site [active] 211586004824 putative Mg binding site IVb [ion binding]; other site 211586004825 putative phosphate binding site [ion binding]; other site 211586004826 putative DNA binding site [nucleotide binding]; other site 211586004827 putative Mg binding site IVa [ion binding]; other site 211586004828 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 211586004829 FOG: PKD repeat [General function prediction only]; Region: COG3291 211586004830 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 211586004831 HSP70 interaction site [polypeptide binding]; other site 211586004832 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 211586004833 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 211586004834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586004835 S-adenosylmethionine binding site [chemical binding]; other site 211586004836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586004837 S-adenosylmethionine binding site [chemical binding]; other site 211586004838 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 211586004839 ABC transporter ATPase component; Reviewed; Region: PRK11147 211586004840 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 211586004841 ABC transporter; Region: ABC_tran_2; pfam12848 211586004842 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 211586004843 Protein of unknown function (DUF3466); Region: DUF3466; pfam11949 211586004844 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 211586004845 ribosome modulation factor; Provisional; Region: PRK14563 211586004846 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 211586004847 active site 1 [active] 211586004848 dimer interface [polypeptide binding]; other site 211586004849 active site 2 [active] 211586004850 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 211586004851 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 211586004852 response regulator; Provisional; Region: PRK09483 211586004853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586004854 active site 211586004855 phosphorylation site [posttranslational modification] 211586004856 intermolecular recognition site; other site 211586004857 dimerization interface [polypeptide binding]; other site 211586004858 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 211586004859 DNA binding residues [nucleotide binding] 211586004860 dimerization interface [polypeptide binding]; other site 211586004861 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 211586004862 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 211586004863 GIY-YIG motif/motif A; other site 211586004864 active site 211586004865 catalytic site [active] 211586004866 putative DNA binding site [nucleotide binding]; other site 211586004867 metal binding site [ion binding]; metal-binding site 211586004868 UvrB/uvrC motif; Region: UVR; pfam02151 211586004869 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 211586004870 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 211586004871 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 211586004872 histone-like DNA-binding protein HU; Region: HU; cd13831 211586004873 dimer interface [polypeptide binding]; other site 211586004874 DNA binding site [nucleotide binding] 211586004875 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 211586004876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211586004877 Walker A/P-loop; other site 211586004878 ATP binding site [chemical binding]; other site 211586004879 Q-loop/lid; other site 211586004880 ABC transporter signature motif; other site 211586004881 Walker B; other site 211586004882 D-loop; other site 211586004883 H-loop/switch region; other site 211586004884 Protein of unknown function, DUF480; Region: DUF480; cl01209 211586004885 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 211586004886 S1 domain; Region: S1_2; pfam13509 211586004887 S1 domain; Region: S1_2; pfam13509 211586004888 arginine decarboxylase; Provisional; Region: PRK05354 211586004889 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 211586004890 dimer interface [polypeptide binding]; other site 211586004891 active site 211586004892 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 211586004893 catalytic residues [active] 211586004894 substrate binding site [chemical binding]; other site 211586004895 Adenosylmethionine decarboxylase; Region: SAM_decarbox; cl03253 211586004896 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 211586004897 short chain dehydrogenase; Region: adh_short; pfam00106 211586004898 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 211586004899 putative NAD(P) binding site [chemical binding]; other site 211586004900 homodimer interface [polypeptide binding]; other site 211586004901 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586004902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586004903 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 211586004904 catalytic triad [active] 211586004905 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 211586004906 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 211586004907 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 211586004908 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 211586004909 dimer interface [polypeptide binding]; other site 211586004910 active site 211586004911 catalytic residue [active] 211586004912 NlpB/DapX lipoprotein; Region: Lipoprotein_18; cl19507 211586004913 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 211586004914 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 211586004915 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586004916 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 211586004917 MMPL family; Region: MMPL; cl14618 211586004918 MMPL family; Region: MMPL; cl14618 211586004919 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 211586004920 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586004921 Coenzyme A binding pocket [chemical binding]; other site 211586004922 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 211586004923 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 211586004924 Putative amidotransferase; Region: DUF4066; pfam13278 211586004925 conserved cys residue [active] 211586004926 Abortive infection C-terminus; Region: Abi_C; pfam14355 211586004927 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 211586004928 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 211586004929 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 211586004930 active site 211586004931 catalytic residues [active] 211586004932 metal binding site [ion binding]; metal-binding site 211586004933 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 211586004934 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 211586004935 ATP-grasp domain; Region: ATP-grasp_4; cl17255 211586004936 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 211586004937 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 211586004938 carboxyltransferase (CT) interaction site; other site 211586004939 biotinylation site [posttranslational modification]; other site 211586004940 enoyl-CoA hydratase; Provisional; Region: PRK05995 211586004941 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 211586004942 substrate binding site [chemical binding]; other site 211586004943 oxyanion hole (OAH) forming residues; other site 211586004944 trimer interface [polypeptide binding]; other site 211586004945 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 211586004946 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 211586004947 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 211586004948 isovaleryl-CoA dehydrogenase; Region: PLN02519 211586004949 substrate binding site [chemical binding]; other site 211586004950 FAD binding site [chemical binding]; other site 211586004951 catalytic base [active] 211586004952 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 211586004953 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 211586004954 DNA binding residues [nucleotide binding] 211586004955 putative dimer interface [polypeptide binding]; other site 211586004956 murein L,D-transpeptidase; Provisional; Region: PRK10594 211586004957 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 211586004958 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 211586004959 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 211586004960 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 211586004961 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 211586004962 acyl-activating enzyme (AAE) consensus motif; other site 211586004963 putative AMP binding site [chemical binding]; other site 211586004964 putative active site [active] 211586004965 putative CoA binding site [chemical binding]; other site 211586004966 mini-ykkC motif 211586004967 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 211586004968 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 211586004969 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 211586004970 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 211586004971 Transposase; Region: HTH_Tnp_1; pfam01527 211586004972 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586004973 putative transposase OrfB; Reviewed; Region: PHA02517 211586004974 HTH-like domain; Region: HTH_21; pfam13276 211586004975 Integrase core domain; Region: rve; pfam00665 211586004976 Integrase core domain; Region: rve_2; pfam13333 211586004977 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586004978 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586004979 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 211586004980 dimerization interface [polypeptide binding]; other site 211586004981 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 211586004982 putative active site [active] 211586004983 metal binding site [ion binding]; metal-binding site 211586004984 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 211586004985 putative active site [active] 211586004986 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 211586004987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 211586004988 NAD(P) binding site [chemical binding]; other site 211586004989 active site 211586004990 acyl-CoA thioesterase II; Provisional; Region: PRK10526 211586004991 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 211586004992 active site 211586004993 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 211586004994 catalytic triad [active] 211586004995 dimer interface [polypeptide binding]; other site 211586004996 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 211586004997 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 211586004998 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 211586004999 Subtilase family; Region: Peptidase_S8; pfam00082 211586005000 active site 211586005001 catalytic triad [active] 211586005002 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 211586005003 PA/protease or protease-like domain interface [polypeptide binding]; other site 211586005004 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 211586005005 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586005006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586005007 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 211586005008 dimerization interface [polypeptide binding]; other site 211586005009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586005010 Major Facilitator Superfamily; Region: MFS_1; pfam07690 211586005011 putative substrate translocation pore; other site 211586005012 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 211586005013 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 211586005014 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 211586005015 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 211586005016 MMPL family; Region: MMPL; cl14618 211586005017 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 211586005018 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 211586005019 MMPL family; Region: MMPL; cl14618 211586005020 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 211586005021 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 211586005022 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586005023 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 211586005024 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 211586005025 dimer interface [polypeptide binding]; other site 211586005026 active site 211586005027 citrylCoA binding site [chemical binding]; other site 211586005028 NADH binding [chemical binding]; other site 211586005029 cationic pore residues; other site 211586005030 oxalacetate/citrate binding site [chemical binding]; other site 211586005031 coenzyme A binding site [chemical binding]; other site 211586005032 catalytic triad [active] 211586005033 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 211586005034 Iron-sulfur protein interface; other site 211586005035 proximal quinone binding site [chemical binding]; other site 211586005036 SdhD (CybS) interface [polypeptide binding]; other site 211586005037 proximal heme binding site [chemical binding]; other site 211586005038 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 211586005039 SdhC subunit interface [polypeptide binding]; other site 211586005040 proximal heme binding site [chemical binding]; other site 211586005041 cardiolipin binding site; other site 211586005042 Iron-sulfur protein interface; other site 211586005043 proximal quinone binding site [chemical binding]; other site 211586005044 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 211586005045 L-aspartate oxidase; Provisional; Region: PRK06175 211586005046 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 211586005047 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 211586005048 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 211586005049 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 211586005050 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 211586005051 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 211586005052 TPP-binding site [chemical binding]; other site 211586005053 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 211586005054 dimer interface [polypeptide binding]; other site 211586005055 PYR/PP interface [polypeptide binding]; other site 211586005056 TPP binding site [chemical binding]; other site 211586005057 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 211586005058 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 211586005059 E3 interaction surface; other site 211586005060 lipoyl attachment site [posttranslational modification]; other site 211586005061 e3 binding domain; Region: E3_binding; pfam02817 211586005062 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 211586005063 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 211586005064 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 211586005065 CoA-ligase; Region: Ligase_CoA; pfam00549 211586005066 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 211586005067 CoA binding domain; Region: CoA_binding; pfam02629 211586005068 CoA-ligase; Region: Ligase_CoA; pfam00549 211586005069 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 211586005070 Rnk N-terminus; Region: Rnk_N; pfam14760 211586005071 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 211586005072 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 211586005073 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 211586005074 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 211586005075 metal binding site 2 [ion binding]; metal-binding site 211586005076 putative DNA binding helix; other site 211586005077 metal binding site 1 [ion binding]; metal-binding site 211586005078 dimer interface [polypeptide binding]; other site 211586005079 structural Zn2+ binding site [ion binding]; other site 211586005080 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 211586005081 NAD+ binding site [chemical binding]; other site 211586005082 substrate binding site [chemical binding]; other site 211586005083 Zn binding site [ion binding]; other site 211586005084 AAA domain; Region: AAA_33; pfam13671 211586005085 AAA domain; Region: AAA_17; cl19128 211586005086 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 211586005087 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 211586005088 Cl binding site [ion binding]; other site 211586005089 oligomer interface [polypeptide binding]; other site 211586005090 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 211586005091 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 211586005092 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211586005093 Zn2+ binding site [ion binding]; other site 211586005094 Mg2+ binding site [ion binding]; other site 211586005095 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 211586005096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211586005097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586005098 ATP binding site [chemical binding]; other site 211586005099 Mg2+ binding site [ion binding]; other site 211586005100 G-X-G motif; other site 211586005101 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 211586005102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586005103 active site 211586005104 phosphorylation site [posttranslational modification] 211586005105 intermolecular recognition site; other site 211586005106 dimerization interface [polypeptide binding]; other site 211586005107 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211586005108 DNA binding site [nucleotide binding] 211586005109 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 211586005110 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 211586005111 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 211586005112 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 211586005113 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 211586005114 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 211586005115 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223 211586005116 Protein of unknown function, DUF482; Region: DUF482; pfam04339 211586005117 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 211586005118 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 211586005119 substrate binding site [chemical binding]; other site 211586005120 Major royal jelly protein; Region: MRJP; pfam03022 211586005121 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 211586005122 dimer interface [polypeptide binding]; other site 211586005123 putative metal binding site [ion binding]; other site 211586005124 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 211586005125 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 211586005126 homotrimer interaction site [polypeptide binding]; other site 211586005127 putative active site [active] 211586005128 maltose O-acetyltransferase; Provisional; Region: PRK10092 211586005129 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 211586005130 active site 211586005131 substrate binding site [chemical binding]; other site 211586005132 trimer interface [polypeptide binding]; other site 211586005133 CoA binding site [chemical binding]; other site 211586005134 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 211586005135 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 211586005136 dimer interface [polypeptide binding]; other site 211586005137 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 211586005138 active site 211586005139 Fe binding site [ion binding]; other site 211586005140 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 211586005141 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586005142 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586005143 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 211586005144 dimerization interface [polypeptide binding]; other site 211586005145 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 211586005146 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 211586005147 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 211586005148 EVE domain; Region: EVE; cl00728 211586005149 AMP-binding domain protein; Validated; Region: PRK08315 211586005150 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 211586005151 acyl-activating enzyme (AAE) consensus motif; other site 211586005152 putative AMP binding site [chemical binding]; other site 211586005153 putative active site [active] 211586005154 putative CoA binding site [chemical binding]; other site 211586005155 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 211586005156 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586005157 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862 211586005158 putative active site [active] 211586005159 Zn binding site [ion binding]; other site 211586005160 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 211586005161 Putative lysophospholipase; Region: Hydrolase_4; cl19140 211586005162 hypothetical protein; Provisional; Region: PRK11770 211586005163 Domain of unknown function (DUF307); Region: DUF307; pfam03733 211586005164 Domain of unknown function (DUF307); Region: DUF307; pfam03733 211586005165 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 211586005166 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 211586005167 catalytic residue [active] 211586005168 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 211586005169 nudix motif; other site 211586005170 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 211586005171 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 211586005172 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 211586005173 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211586005174 active site 211586005175 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 211586005176 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 211586005177 active site 211586005178 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 211586005179 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 211586005180 RNA polymerase sigma factor; Provisional; Region: PRK11924 211586005181 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 211586005182 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 211586005183 DNA binding residues [nucleotide binding] 211586005184 ATP-dependent protease La (LON) domain; Region: LON; cl19481 211586005185 Methyltransferase domain; Region: Methyltransf_31; pfam13847 211586005186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586005187 S-adenosylmethionine binding site [chemical binding]; other site 211586005188 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 211586005189 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 211586005190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586005191 active site 211586005192 phosphorylation site [posttranslational modification] 211586005193 intermolecular recognition site; other site 211586005194 dimerization interface [polypeptide binding]; other site 211586005195 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 211586005196 lytic murein transglycosylase; Region: MltB_2; TIGR02283 211586005197 Transglycosylase SLT domain; Region: SLT_2; pfam13406 211586005198 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 211586005199 N-acetyl-D-glucosamine binding site [chemical binding]; other site 211586005200 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 211586005201 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl19519 211586005202 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 211586005203 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 211586005204 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 211586005205 active site 211586005206 Zn binding site [ion binding]; other site 211586005207 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 211586005208 Protein of unknown function (DUF3389); Region: DUF3389; pfam11869 211586005209 Predicted esterase [General function prediction only]; Region: COG0400 211586005210 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 211586005211 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 211586005212 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 211586005213 active site 211586005214 metal binding site [ion binding]; metal-binding site 211586005215 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 211586005216 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 211586005217 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 211586005218 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 211586005219 FMN binding site [chemical binding]; other site 211586005220 active site 211586005221 catalytic residues [active] 211586005222 substrate binding site [chemical binding]; other site 211586005223 Uncharacterized low-complexity protein [Function unknown]; Region: COG3767 211586005224 hypothetical protein; Provisional; Region: PRK05409 211586005225 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 211586005226 hypothetical protein; Provisional; Region: PRK10527 211586005227 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211586005228 active site 211586005229 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14949 211586005230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586005231 Walker A motif; other site 211586005232 ATP binding site [chemical binding]; other site 211586005233 Walker B motif; other site 211586005234 DNA polymerase III subunit delta'; Validated; Region: PRK08485 211586005235 arginine finger; other site 211586005236 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 211586005237 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 211586005238 hypothetical protein; Validated; Region: PRK00153 211586005239 recombination protein RecR; Reviewed; Region: recR; PRK00076 211586005240 RecR protein; Region: RecR; pfam02132 211586005241 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 211586005242 putative active site [active] 211586005243 putative metal-binding site [ion binding]; other site 211586005244 tetramer interface [polypeptide binding]; other site 211586005245 heat shock protein 90; Provisional; Region: PRK05218 211586005246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586005247 ATP binding site [chemical binding]; other site 211586005248 Mg2+ binding site [ion binding]; other site 211586005249 G-X-G motif; other site 211586005250 Hsp90 protein; Region: HSP90; pfam00183 211586005251 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 211586005252 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 211586005253 Tetratricopeptide repeat; Region: TPR_20; pfam14561 211586005254 adenylate kinase; Reviewed; Region: adk; PRK00279 211586005255 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 211586005256 AMP-binding site [chemical binding]; other site 211586005257 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 211586005258 ferrochelatase; Reviewed; Region: hemH; PRK00035 211586005259 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 211586005260 C-terminal domain interface [polypeptide binding]; other site 211586005261 active site 211586005262 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 211586005263 active site 211586005264 N-terminal domain interface [polypeptide binding]; other site 211586005265 inosine/guanosine kinase; Provisional; Region: PRK15074 211586005266 substrate binding site [chemical binding]; other site 211586005267 ATP binding site [chemical binding]; other site 211586005268 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 211586005269 homodimer interface [polypeptide binding]; other site 211586005270 NAD binding pocket [chemical binding]; other site 211586005271 ATP binding pocket [chemical binding]; other site 211586005272 Mg binding site [ion binding]; other site 211586005273 active-site loop [active] 211586005274 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 211586005275 Transposase; Region: HTH_Tnp_1; pfam01527 211586005276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586005277 putative transposase OrfB; Reviewed; Region: PHA02517 211586005278 HTH-like domain; Region: HTH_21; pfam13276 211586005279 Integrase core domain; Region: rve; pfam00665 211586005280 Integrase core domain; Region: rve_2; pfam13333 211586005281 Transposase; Region: HTH_Tnp_1; pfam01527 211586005282 Winged helix-turn helix; Region: HTH_29; pfam13551 211586005283 HTH-like domain; Region: HTH_21; pfam13276 211586005284 Integrase core domain; Region: rve; pfam00665 211586005285 Integrase core domain; Region: rve_3; pfam13683 211586005286 Transposase; Region: HTH_Tnp_1; pfam01527 211586005287 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586005288 putative transposase OrfB; Reviewed; Region: PHA02517 211586005289 HTH-like domain; Region: HTH_21; pfam13276 211586005290 Integrase core domain; Region: rve; pfam00665 211586005291 Integrase core domain; Region: rve_2; pfam13333 211586005292 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 211586005293 Putative transposase; Region: Y2_Tnp; pfam04986 211586005294 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 211586005295 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 211586005296 active site 211586005297 DNA binding site [nucleotide binding] 211586005298 Int/Topo IB signature motif; other site 211586005299 integron integrase; Region: integrase_gron; TIGR02249 211586005300 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 211586005301 Int/Topo IB signature motif; other site 211586005302 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586005303 lytic murein transglycosylase; Provisional; Region: PRK11619 211586005304 Soluble lytic murein transglycosylase L domain; Region: SLT_L; pfam14718 211586005305 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 211586005306 N-acetyl-D-glucosamine binding site [chemical binding]; other site 211586005307 catalytic residue [active] 211586005308 DNA recombination protein RmuC; Provisional; Region: PRK10361 211586005309 RmuC family; Region: RmuC; pfam02646 211586005310 TMAO/DMSO reductase; Reviewed; Region: PRK05363 211586005311 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 211586005312 Moco binding site; other site 211586005313 metal coordination site [ion binding]; other site 211586005314 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 211586005315 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 211586005316 dimer interface [polypeptide binding]; other site 211586005317 active site 211586005318 metal binding site [ion binding]; metal-binding site 211586005319 glutathione binding site [chemical binding]; other site 211586005320 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 211586005321 Transcriptional regulators [Transcription]; Region: MarR; COG1846 211586005322 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 211586005323 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 211586005324 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 211586005325 putative metal dependent hydrolase; Provisional; Region: PRK11598 211586005326 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 211586005327 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 211586005328 Sulfatase; Region: Sulfatase; pfam00884 211586005329 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586005330 metal binding site [ion binding]; metal-binding site 211586005331 active site 211586005332 I-site; other site 211586005333 Protein of unknown function (DUF938); Region: DUF938; pfam06080 211586005334 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 211586005335 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 211586005336 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586005337 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586005338 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 211586005339 dimerization interface [polypeptide binding]; other site 211586005340 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 211586005341 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 211586005342 substrate binding site [chemical binding]; other site 211586005343 catalytic Zn binding site [ion binding]; other site 211586005344 NAD binding site [chemical binding]; other site 211586005345 structural Zn binding site [ion binding]; other site 211586005346 dimer interface [polypeptide binding]; other site 211586005347 Predicted esterase [General function prediction only]; Region: COG0627 211586005348 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 211586005349 Transposase; Region: HTH_Tnp_1; pfam01527 211586005350 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586005351 putative transposase OrfB; Reviewed; Region: PHA02517 211586005352 HTH-like domain; Region: HTH_21; pfam13276 211586005353 Integrase core domain; Region: rve; pfam00665 211586005354 Integrase core domain; Region: rve_2; pfam13333 211586005355 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 211586005356 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 211586005357 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 211586005358 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 211586005359 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 211586005360 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 211586005361 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 211586005362 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 211586005363 metal binding site [ion binding]; metal-binding site 211586005364 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 211586005365 substrate binding site [chemical binding]; other site 211586005366 glutamase interaction surface [polypeptide binding]; other site 211586005367 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 211586005368 catalytic residues [active] 211586005369 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 211586005370 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 211586005371 putative active site [active] 211586005372 oxyanion strand; other site 211586005373 catalytic triad [active] 211586005374 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 211586005375 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211586005376 active site 211586005377 motif I; other site 211586005378 motif II; other site 211586005379 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 211586005380 putative active site pocket [active] 211586005381 4-fold oligomerization interface [polypeptide binding]; other site 211586005382 metal binding residues [ion binding]; metal-binding site 211586005383 3-fold/trimer interface [polypeptide binding]; other site 211586005384 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 211586005385 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 211586005386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586005387 homodimer interface [polypeptide binding]; other site 211586005388 catalytic residue [active] 211586005389 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 211586005390 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 211586005391 NAD binding site [chemical binding]; other site 211586005392 dimerization interface [polypeptide binding]; other site 211586005393 product binding site; other site 211586005394 substrate binding site [chemical binding]; other site 211586005395 zinc binding site [ion binding]; other site 211586005396 catalytic residues [active] 211586005397 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 211586005398 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 211586005399 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 211586005400 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586005401 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586005402 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 211586005403 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 211586005404 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 211586005405 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 211586005406 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 211586005407 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 211586005408 dimer interface [polypeptide binding]; other site 211586005409 putative CheW interface [polypeptide binding]; other site 211586005410 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 211586005411 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 211586005412 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 211586005413 dimer interface [polypeptide binding]; other site 211586005414 motif 1; other site 211586005415 active site 211586005416 motif 2; other site 211586005417 motif 3; other site 211586005418 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 211586005419 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 211586005420 putative tRNA-binding site [nucleotide binding]; other site 211586005421 B3/4 domain; Region: B3_4; pfam03483 211586005422 tRNA synthetase B5 domain; Region: B5; smart00874 211586005423 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 211586005424 dimer interface [polypeptide binding]; other site 211586005425 motif 1; other site 211586005426 motif 3; other site 211586005427 motif 2; other site 211586005428 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 211586005429 Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835 211586005430 DNA binding site [nucleotide binding] 211586005431 dimer interface [polypeptide binding]; other site 211586005432 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 211586005433 putative acyl-acceptor binding pocket; other site 211586005434 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 211586005435 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 211586005436 dimerization interface [polypeptide binding]; other site 211586005437 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 211586005438 ATP binding site [chemical binding]; other site 211586005439 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 211586005440 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 211586005441 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 211586005442 Acylphosphatase; Region: Acylphosphatase; pfam00708 211586005443 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 211586005444 HypF finger; Region: zf-HYPF; pfam07503 211586005445 HypF finger; Region: zf-HYPF; pfam07503 211586005446 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 211586005447 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl09782 211586005448 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 211586005449 putative substrate-binding site; other site 211586005450 nickel binding site [ion binding]; other site 211586005451 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 211586005452 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 211586005453 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 211586005454 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 211586005455 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 211586005456 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 211586005457 catalytic residues [active] 211586005458 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 211586005459 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 211586005460 ApbE family; Region: ApbE; pfam02424 211586005461 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211586005462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586005463 active site 211586005464 phosphorylation site [posttranslational modification] 211586005465 intermolecular recognition site; other site 211586005466 dimerization interface [polypeptide binding]; other site 211586005467 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211586005468 DNA binding site [nucleotide binding] 211586005469 sensor protein QseC; Provisional; Region: PRK10337 211586005470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586005471 dimer interface [polypeptide binding]; other site 211586005472 phosphorylation site [posttranslational modification] 211586005473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586005474 ATP binding site [chemical binding]; other site 211586005475 Mg2+ binding site [ion binding]; other site 211586005476 G-X-G motif; other site 211586005477 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 211586005478 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 211586005479 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 211586005480 Ligand binding site; other site 211586005481 DXD motif; other site 211586005482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 211586005483 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 211586005484 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 211586005485 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 211586005486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 211586005487 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 211586005488 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 211586005489 5S rRNA interface [nucleotide binding]; other site 211586005490 CTC domain interface [polypeptide binding]; other site 211586005491 L16 interface [polypeptide binding]; other site 211586005492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 211586005493 Family of unknown function (DUF490); Region: DUF490; pfam04357 211586005494 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 211586005495 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 211586005496 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 211586005497 Surface antigen; Region: Bac_surface_Ag; pfam01103 211586005498 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 211586005499 catalytic nucleophile [active] 211586005500 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 211586005501 CoA binding domain; Region: CoA_binding_2; pfam13380 211586005502 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 211586005503 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 211586005504 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 211586005505 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 211586005506 dimer interface [polypeptide binding]; other site 211586005507 putative CheW interface [polypeptide binding]; other site 211586005508 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 211586005509 anti sigma factor interaction site; other site 211586005510 regulatory phosphorylation site [posttranslational modification]; other site 211586005511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586005512 active site 211586005513 phosphorylation site [posttranslational modification] 211586005514 intermolecular recognition site; other site 211586005515 SNF-7-like protein; Provisional; Region: PTZ00464 211586005516 dimerization interface [polypeptide binding]; other site 211586005517 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 211586005518 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 211586005519 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211586005520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586005521 active site 211586005522 phosphorylation site [posttranslational modification] 211586005523 intermolecular recognition site; other site 211586005524 dimerization interface [polypeptide binding]; other site 211586005525 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 211586005526 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 211586005527 putative binding surface; other site 211586005528 active site 211586005529 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 211586005530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586005531 ATP binding site [chemical binding]; other site 211586005532 Mg2+ binding site [ion binding]; other site 211586005533 G-X-G motif; other site 211586005534 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 211586005535 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 211586005536 putative CheA interaction surface; other site 211586005537 PAS domain; Region: PAS_8; pfam13188 211586005538 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 211586005539 PAS domain; Region: PAS; smart00091 211586005540 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 211586005541 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 211586005542 dimer interface [polypeptide binding]; other site 211586005543 putative CheW interface [polypeptide binding]; other site 211586005544 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 211586005545 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 211586005546 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 211586005547 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487 211586005548 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 211586005549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586005550 active site 211586005551 phosphorylation site [posttranslational modification] 211586005552 intermolecular recognition site; other site 211586005553 dimerization interface [polypeptide binding]; other site 211586005554 CheB methylesterase; Region: CheB_methylest; pfam01339 211586005555 Hpt domain; Region: Hpt; pfam01627 211586005556 putative binding surface; other site 211586005557 active site 211586005558 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211586005559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586005560 active site 211586005561 phosphorylation site [posttranslational modification] 211586005562 intermolecular recognition site; other site 211586005563 dimerization interface [polypeptide binding]; other site 211586005564 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586005565 metal binding site [ion binding]; metal-binding site 211586005566 active site 211586005567 I-site; other site 211586005568 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 211586005569 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586005570 Transposase [DNA replication, recombination, and repair]; Region: COG5433 211586005571 Transposase; Region: HTH_Tnp_1; pfam01527 211586005572 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586005573 putative transposase OrfB; Reviewed; Region: PHA02517 211586005574 HTH-like domain; Region: HTH_21; pfam13276 211586005575 Integrase core domain; Region: rve; pfam00665 211586005576 Integrase core domain; Region: rve_2; pfam13333 211586005577 Transposase; Region: HTH_Tnp_1; pfam01527 211586005578 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586005579 putative transposase OrfB; Reviewed; Region: PHA02517 211586005580 HTH-like domain; Region: HTH_21; pfam13276 211586005581 Integrase core domain; Region: rve; pfam00665 211586005582 Integrase core domain; Region: rve_2; pfam13333 211586005583 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 211586005584 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 211586005585 putative catalytic cysteine [active] 211586005586 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 211586005587 putative active site [active] 211586005588 metal binding site [ion binding]; metal-binding site 211586005589 hypothetical protein; Provisional; Region: PRK11111 211586005590 Homeodomain-like domain; Region: HTH_23; pfam13384 211586005591 Winged helix-turn helix; Region: HTH_29; pfam13551 211586005592 DDE superfamily endonuclease; Region: DDE_3; pfam13358 211586005593 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 211586005594 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 211586005595 TrkA-C domain; Region: TrkA_C; pfam02080 211586005596 TrkA-C domain; Region: TrkA_C; pfam02080 211586005597 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 211586005598 Heme NO binding; Region: HNOB; pfam07700 211586005599 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586005600 dimer interface [polypeptide binding]; other site 211586005601 phosphorylation site [posttranslational modification] 211586005602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586005603 ATP binding site [chemical binding]; other site 211586005604 Mg2+ binding site [ion binding]; other site 211586005605 G-X-G motif; other site 211586005606 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 211586005607 AAA domain; Region: AAA_30; pfam13604 211586005608 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 211586005609 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 211586005610 Part of AAA domain; Region: AAA_19; pfam13245 211586005611 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 211586005612 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 211586005613 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 211586005614 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 211586005615 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 211586005616 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 211586005617 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 211586005618 Protein of unknown function DUF58; Region: DUF58; pfam01882 211586005619 MoxR-like ATPases [General function prediction only]; Region: COG0714 211586005620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586005621 Walker A motif; other site 211586005622 ATP binding site [chemical binding]; other site 211586005623 Walker B motif; other site 211586005624 arginine finger; other site 211586005625 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 211586005626 putative metal binding site [ion binding]; other site 211586005627 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349 211586005628 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 211586005629 active site 211586005630 catalytic site [active] 211586005631 Transposase; Region: HTH_Tnp_1; pfam01527 211586005632 Winged helix-turn helix; Region: HTH_29; pfam13551 211586005633 HTH-like domain; Region: HTH_21; pfam13276 211586005634 Integrase core domain; Region: rve; pfam00665 211586005635 Integrase core domain; Region: rve_3; pfam13683 211586005636 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 211586005637 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 211586005638 Int/Topo IB signature motif; other site 211586005639 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 211586005640 Putative transposase; Region: Y2_Tnp; pfam04986 211586005641 Transposase; Region: HTH_Tnp_1; pfam01527 211586005642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586005643 putative transposase OrfB; Reviewed; Region: PHA02517 211586005644 HTH-like domain; Region: HTH_21; pfam13276 211586005645 Integrase core domain; Region: rve; pfam00665 211586005646 Integrase core domain; Region: rve_2; pfam13333 211586005647 Transposase; Region: HTH_Tnp_1; pfam01527 211586005648 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586005649 putative transposase OrfB; Reviewed; Region: PHA02517 211586005650 HTH-like domain; Region: HTH_21; pfam13276 211586005651 Integrase core domain; Region: rve; pfam00665 211586005652 Integrase core domain; Region: rve_2; pfam13333 211586005653 PAS domain; Region: PAS_9; pfam13426 211586005654 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586005655 metal binding site [ion binding]; metal-binding site 211586005656 active site 211586005657 I-site; other site 211586005658 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 211586005659 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 211586005660 Sulfatase; Region: Sulfatase; cl19157 211586005661 hypothetical protein; Provisional; Region: PRK13689 211586005662 nucleoid-associated protein NdpA; Validated; Region: PRK00378 211586005663 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 211586005664 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 211586005665 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 211586005666 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 211586005667 Predicted small secreted protein [Function unknown]; Region: COG5584 211586005668 Peptidase family M23; Region: Peptidase_M23; pfam01551 211586005669 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 211586005670 putative metal binding site [ion binding]; other site 211586005671 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 211586005672 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 211586005673 exopolyphosphatase; Region: exo_poly_only; TIGR03706 211586005674 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 211586005675 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 211586005676 putative chaperone; Provisional; Region: PRK11678 211586005677 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 211586005678 nucleotide binding site [chemical binding]; other site 211586005679 putative NEF/HSP70 interaction site [polypeptide binding]; other site 211586005680 SBD interface [polypeptide binding]; other site 211586005681 CreA protein; Region: CreA; pfam05981 211586005682 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 211586005683 homodimer interface [polypeptide binding]; other site 211586005684 substrate-cofactor binding pocket; other site 211586005685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586005686 catalytic residue [active] 211586005687 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 211586005688 DOMON-like type 9 carbohydrate binding module at the N-terminus of bacterial sensor histidine kinases; Region: CBM9_like_HisKa; cd09622 211586005689 putative ligand binding site [chemical binding]; other site 211586005690 HAMP domain; Region: HAMP; pfam00672 211586005691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586005692 dimer interface [polypeptide binding]; other site 211586005693 phosphorylation site [posttranslational modification] 211586005694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586005695 ATP binding site [chemical binding]; other site 211586005696 Mg2+ binding site [ion binding]; other site 211586005697 G-X-G motif; other site 211586005698 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 211586005699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586005700 active site 211586005701 phosphorylation site [posttranslational modification] 211586005702 intermolecular recognition site; other site 211586005703 dimerization interface [polypeptide binding]; other site 211586005704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211586005705 DNA binding site [nucleotide binding] 211586005706 proteobacterial sortase system OmpA family protein; Region: pdsO; TIGR03789 211586005707 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 211586005708 ligand binding site [chemical binding]; other site 211586005709 Vault protein inter-alpha-trypsin domain; Region: VIT; pfam08487 211586005710 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 211586005711 vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461 211586005712 metal ion-dependent adhesion site (MIDAS); other site 211586005713 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 211586005714 active site 211586005715 catalytic site [active] 211586005716 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 211586005717 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586005718 metal binding site [ion binding]; metal-binding site 211586005719 active site 211586005720 I-site; other site 211586005721 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 211586005722 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 211586005723 PA/protease or protease-like domain interface [polypeptide binding]; other site 211586005724 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 211586005725 metal binding site [ion binding]; metal-binding site 211586005726 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 211586005727 ATP-grasp domain; Region: ATP-grasp_4; cl17255 211586005728 hypothetical protein; Provisional; Region: PRK11027 211586005729 transcriptional regulator HdfR; Provisional; Region: PRK03601 211586005730 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586005731 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 211586005732 dimerization interface [polypeptide binding]; other site 211586005733 Integral membrane diacylglycerol kinase; Region: DAGK_IM; cd14264 211586005734 putative active site [active] 211586005735 trimer interface [polypeptide binding]; other site 211586005736 putative active site [active] 211586005737 Zn binding site [ion binding]; other site 211586005738 DNA ligase; Provisional; Region: PRK09125 211586005739 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 211586005740 DNA binding site [nucleotide binding] 211586005741 active site 211586005742 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 211586005743 DNA binding site [nucleotide binding] 211586005744 Low molecular weight phosphatase family; Region: LMWPc; cd00115 211586005745 active site 211586005746 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 211586005747 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 211586005748 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 211586005749 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 211586005750 Int/Topo IB signature motif; other site 211586005751 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 211586005752 Putative transposase; Region: Y2_Tnp; pfam04986 211586005753 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 211586005754 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 211586005755 active site 211586005756 catalytic site [active] 211586005757 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 211586005758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586005759 S-adenosylmethionine binding site [chemical binding]; other site 211586005760 GAF domain; Region: GAF_2; pfam13185 211586005761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586005762 PAS domain; Region: PAS_9; pfam13426 211586005763 putative active site [active] 211586005764 heme pocket [chemical binding]; other site 211586005765 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586005766 metal binding site [ion binding]; metal-binding site 211586005767 active site 211586005768 I-site; other site 211586005769 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586005770 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 211586005771 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 211586005772 ATP-grasp domain; Region: ATP-grasp_4; cl17255 211586005773 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 211586005774 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 211586005775 putative dimer interface [polypeptide binding]; other site 211586005776 putative anticodon binding site; other site 211586005777 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 211586005778 homodimer interface [polypeptide binding]; other site 211586005779 motif 1; other site 211586005780 motif 2; other site 211586005781 active site 211586005782 motif 3; other site 211586005783 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 211586005784 putative active site [active] 211586005785 putative CoA binding site [chemical binding]; other site 211586005786 nudix motif; other site 211586005787 metal binding site [ion binding]; metal-binding site 211586005788 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 211586005789 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 211586005790 chorismate binding enzyme; Region: Chorismate_bind; cl10555 211586005791 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 211586005792 Fumarase C-terminus; Region: Fumerase_C; pfam05683 211586005793 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 211586005794 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 211586005795 nitrobindin heme-binding domain; Region: nitrobindin; cl10502 211586005796 heme-binding site [chemical binding]; other site 211586005797 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 211586005798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 211586005799 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 211586005800 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 211586005801 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 211586005802 putative active site [active] 211586005803 Zn binding site [ion binding]; other site 211586005804 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586005805 FOG: CBS domain [General function prediction only]; Region: COG0517 211586005806 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 211586005807 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 211586005808 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211586005809 ATP binding site [chemical binding]; other site 211586005810 putative Mg++ binding site [ion binding]; other site 211586005811 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586005812 nucleotide binding region [chemical binding]; other site 211586005813 ATP-binding site [chemical binding]; other site 211586005814 Helicase associated domain (HA2); Region: HA2; pfam04408 211586005815 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 211586005816 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 211586005817 PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439 211586005818 HPr interaction site; other site 211586005819 glycerol kinase (GK) interaction site [polypeptide binding]; other site 211586005820 active site 211586005821 phosphorylation site [posttranslational modification] 211586005822 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 211586005823 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 211586005824 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 211586005825 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 211586005826 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 211586005827 dimerization domain swap beta strand [polypeptide binding]; other site 211586005828 regulatory protein interface [polypeptide binding]; other site 211586005829 active site 211586005830 regulatory phosphorylation site [posttranslational modification]; other site 211586005831 Uncharacterized conserved protein [Function unknown]; Region: COG3603 211586005832 ACT domain; Region: ACT_7; pfam13840 211586005833 Cache domain; Region: Cache_2; pfam08269 211586005834 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586005835 dimerization interface [polypeptide binding]; other site 211586005836 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 211586005837 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 211586005838 dimer interface [polypeptide binding]; other site 211586005839 putative CheW interface [polypeptide binding]; other site 211586005840 Protein of unknown function (DUF3334); Region: DUF3334; pfam11813 211586005841 Transcriptional regulators [Transcription]; Region: PurR; COG1609 211586005842 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 211586005843 DNA binding site [nucleotide binding] 211586005844 domain linker motif; other site 211586005845 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 211586005846 putative dimerization interface [polypeptide binding]; other site 211586005847 putative ligand binding site [chemical binding]; other site 211586005848 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 211586005849 active site 211586005850 catalytic site [active] 211586005851 substrate binding site [chemical binding]; other site 211586005852 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 211586005853 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 211586005854 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 211586005855 beta-hexosaminidase; Provisional; Region: PRK05337 211586005856 hypothetical protein; Provisional; Region: PRK04940 211586005857 acylphosphatase; Provisional; Region: PRK14429 211586005858 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 211586005859 transcription-repair coupling factor; Provisional; Region: PRK10689 211586005860 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 211586005861 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211586005862 ATP binding site [chemical binding]; other site 211586005863 putative Mg++ binding site [ion binding]; other site 211586005864 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586005865 nucleotide binding region [chemical binding]; other site 211586005866 ATP-binding site [chemical binding]; other site 211586005867 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 211586005868 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 211586005869 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 211586005870 FtsX-like permease family; Region: FtsX; pfam02687 211586005871 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 211586005872 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 211586005873 Walker A/P-loop; other site 211586005874 ATP binding site [chemical binding]; other site 211586005875 Q-loop/lid; other site 211586005876 ABC transporter signature motif; other site 211586005877 Walker B; other site 211586005878 D-loop; other site 211586005879 H-loop/switch region; other site 211586005880 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 211586005881 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 211586005882 FtsX-like permease family; Region: FtsX; pfam02687 211586005883 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 211586005884 active site 211586005885 dimerization interface [polypeptide binding]; other site 211586005886 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 211586005887 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 211586005888 serine O-acetyltransferase; Region: cysE; TIGR01172 211586005889 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 211586005890 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 211586005891 trimer interface [polypeptide binding]; other site 211586005892 active site 211586005893 substrate binding site [chemical binding]; other site 211586005894 CoA binding site [chemical binding]; other site 211586005895 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 211586005896 Rrf2 family protein; Region: rrf2_super; TIGR00738 211586005897 cysteine desulfurase; Provisional; Region: PRK14012 211586005898 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 211586005899 catalytic residue [active] 211586005900 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 211586005901 trimerization site [polypeptide binding]; other site 211586005902 active site 211586005903 iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011 211586005904 co-chaperone HscB; Provisional; Region: hscB; PRK05014 211586005905 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 211586005906 HSP70 interaction site [polypeptide binding]; other site 211586005907 HSCB C-terminal oligomerization domain; Region: HSCB_C; pfam07743 211586005908 chaperone protein HscA; Provisional; Region: hscA; PRK05183 211586005909 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 211586005910 nucleotide binding site [chemical binding]; other site 211586005911 putative NEF/HSP70 interaction site [polypeptide binding]; other site 211586005912 SBD interface [polypeptide binding]; other site 211586005913 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 211586005914 catalytic loop [active] 211586005915 iron binding site [ion binding]; other site 211586005916 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 211586005917 ATP-grasp domain; Region: ATP-grasp_4; cl17255 211586005918 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 211586005919 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586005920 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586005921 Nucleoside diphosphate kinase; Region: NDK; pfam00334 211586005922 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 211586005923 active site 211586005924 multimer interface [polypeptide binding]; other site 211586005925 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 211586005926 Homeodomain-like domain; Region: HTH_23; pfam13384 211586005927 Winged helix-turn helix; Region: HTH_33; pfam13592 211586005928 DDE superfamily endonuclease; Region: DDE_3; pfam13358 211586005929 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 211586005930 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 211586005931 putative dimer interface [polypeptide binding]; other site 211586005932 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 211586005933 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 211586005934 putative valine binding site [chemical binding]; other site 211586005935 dimer interface [polypeptide binding]; other site 211586005936 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 211586005937 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08979 211586005938 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 211586005939 PYR/PP interface [polypeptide binding]; other site 211586005940 dimer interface [polypeptide binding]; other site 211586005941 TPP binding site [chemical binding]; other site 211586005942 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 211586005943 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 211586005944 TPP-binding site [chemical binding]; other site 211586005945 dimer interface [polypeptide binding]; other site 211586005946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586005947 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 211586005948 putative substrate translocation pore; other site 211586005949 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 211586005950 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 211586005951 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 211586005952 DNA-binding site [nucleotide binding]; DNA binding site 211586005953 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 211586005954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586005955 homodimer interface [polypeptide binding]; other site 211586005956 catalytic residue [active] 211586005957 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586005958 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 211586005959 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 211586005960 Sulfate transporter family; Region: Sulfate_transp; pfam00916 211586005961 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 211586005962 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 211586005963 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 211586005964 active site residue [active] 211586005965 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586005966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586005967 multidrug efflux protein; Reviewed; Region: PRK01766 211586005968 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 211586005969 cation binding site [ion binding]; other site 211586005970 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 211586005971 Lumazine binding domain; Region: Lum_binding; pfam00677 211586005972 Lumazine binding domain; Region: Lum_binding; pfam00677 211586005973 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 211586005974 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 211586005975 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 211586005976 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 211586005977 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 211586005978 active site 211586005979 dimer interface [polypeptide binding]; other site 211586005980 motif 1; other site 211586005981 motif 2; other site 211586005982 motif 3; other site 211586005983 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 211586005984 anticodon binding site; other site 211586005985 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 211586005986 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 211586005987 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 211586005988 long range pseudoknot LR-PK1 211586005989 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 211586005990 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 211586005991 23S rRNA binding site [nucleotide binding]; other site 211586005992 L21 binding site [polypeptide binding]; other site 211586005993 L13 binding site [polypeptide binding]; other site 211586005994 thioredoxin reductase; Provisional; Region: PRK10262 211586005995 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 211586005996 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 211586005997 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 211586005998 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 211586005999 hexamer interface [polypeptide binding]; other site 211586006000 ligand binding site [chemical binding]; other site 211586006001 putative active site [active] 211586006002 NAD(P) binding site [chemical binding]; other site 211586006003 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 211586006004 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 211586006005 putative DNA binding site [nucleotide binding]; other site 211586006006 putative Zn2+ binding site [ion binding]; other site 211586006007 AsnC family; Region: AsnC_trans_reg; pfam01037 211586006008 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 211586006009 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 211586006010 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 211586006011 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 211586006012 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 211586006013 recombination factor protein RarA; Reviewed; Region: PRK13342 211586006014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586006015 Walker A motif; other site 211586006016 ATP binding site [chemical binding]; other site 211586006017 Walker B motif; other site 211586006018 arginine finger; other site 211586006019 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 211586006020 camphor resistance protein CrcB; Provisional; Region: PRK14197 211586006021 seryl-tRNA synthetase; Provisional; Region: PRK05431 211586006022 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 211586006023 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 211586006024 dimer interface [polypeptide binding]; other site 211586006025 active site 211586006026 motif 1; other site 211586006027 motif 2; other site 211586006028 motif 3; other site 211586006029 ecotin; Provisional; Region: PRK03719 211586006030 secondary substrate binding site; other site 211586006031 primary substrate binding site; other site 211586006032 inhibition loop; other site 211586006033 dimerization interface [polypeptide binding]; other site 211586006034 Transposase; Region: HTH_Tnp_1; pfam01527 211586006035 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586006036 putative transposase OrfB; Reviewed; Region: PHA02517 211586006037 HTH-like domain; Region: HTH_21; pfam13276 211586006038 Integrase core domain; Region: rve; pfam00665 211586006039 Integrase core domain; Region: rve_2; pfam13333 211586006040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586006041 active site 211586006042 phosphorylation site [posttranslational modification] 211586006043 intermolecular recognition site; other site 211586006044 dimerization interface [polypeptide binding]; other site 211586006045 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 211586006046 anti sigma factor interaction site; other site 211586006047 regulatory phosphorylation site [posttranslational modification]; other site 211586006048 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586006049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586006050 HAMP domain; Region: HAMP; pfam00672 211586006051 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 211586006052 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 211586006053 dimer interface [polypeptide binding]; other site 211586006054 putative CheW interface [polypeptide binding]; other site 211586006055 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 211586006056 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 211586006057 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 211586006058 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 211586006059 CheD chemotactic sensory transduction; Region: CheD; cl00810 211586006060 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 211586006061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586006062 active site 211586006063 phosphorylation site [posttranslational modification] 211586006064 intermolecular recognition site; other site 211586006065 dimerization interface [polypeptide binding]; other site 211586006066 CheB methylesterase; Region: CheB_methylest; pfam01339 211586006067 elongation factor P; Validated; Region: PRK00529 211586006068 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 211586006069 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 211586006070 RNA binding site [nucleotide binding]; other site 211586006071 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 211586006072 RNA binding site [nucleotide binding]; other site 211586006073 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 211586006074 flavodoxin FldA; Validated; Region: PRK09267 211586006075 LexA regulated protein; Provisional; Region: PRK11675 211586006076 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 211586006077 Putative lysophospholipase; Region: Hydrolase_4; cl19140 211586006078 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 211586006079 replication initiation regulator SeqA; Provisional; Region: PRK11187 211586006080 phosphoglucomutase; Validated; Region: PRK07564 211586006081 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 211586006082 active site 211586006083 substrate binding site [chemical binding]; other site 211586006084 metal binding site [ion binding]; metal-binding site 211586006085 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 211586006086 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 211586006087 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 211586006088 putative active site [active] 211586006089 Zn binding site [ion binding]; other site 211586006090 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 211586006091 tetramer interface [polypeptide binding]; other site 211586006092 TPP-binding site [chemical binding]; other site 211586006093 heterodimer interface [polypeptide binding]; other site 211586006094 phosphorylation loop region [posttranslational modification] 211586006095 3-methyl-2-oxobutanate dehydrogenase; Provisional; Region: PTZ00182 211586006096 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 211586006097 alpha subunit interface [polypeptide binding]; other site 211586006098 TPP binding site [chemical binding]; other site 211586006099 heterodimer interface [polypeptide binding]; other site 211586006100 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 211586006101 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 211586006102 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 211586006103 E3 interaction surface; other site 211586006104 lipoyl attachment site [posttranslational modification]; other site 211586006105 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 211586006106 E3 interaction surface; other site 211586006107 lipoyl attachment site [posttranslational modification]; other site 211586006108 e3 binding domain; Region: E3_binding; pfam02817 211586006109 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 211586006110 quinolinate synthetase; Provisional; Region: PRK09375 211586006111 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586006112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586006113 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 211586006114 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 211586006115 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 211586006116 Protein of unknown function (DUF2989); Region: DUF2989; pfam11207 211586006117 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 211586006118 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 211586006119 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 211586006120 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 211586006121 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 211586006122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586006123 homodimer interface [polypeptide binding]; other site 211586006124 catalytic residue [active] 211586006125 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 211586006126 phosphate binding site [ion binding]; other site 211586006127 putative substrate binding pocket [chemical binding]; other site 211586006128 dimer interface [polypeptide binding]; other site 211586006129 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 211586006130 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 211586006131 Protein of unknown function (DUF2987); Region: DUF2987; pfam11205 211586006132 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 211586006133 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 211586006134 Ligand Binding Site [chemical binding]; other site 211586006135 universal stress protein UspE; Provisional; Region: PRK11175 211586006136 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 211586006137 Ligand Binding Site [chemical binding]; other site 211586006138 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 211586006139 Ligand Binding Site [chemical binding]; other site 211586006140 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 211586006141 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 211586006142 ligand binding site [chemical binding]; other site 211586006143 flexible hinge region; other site 211586006144 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 211586006145 putative switch regulator; other site 211586006146 non-specific DNA interactions [nucleotide binding]; other site 211586006147 DNA binding site [nucleotide binding] 211586006148 sequence specific DNA binding site [nucleotide binding]; other site 211586006149 putative cAMP binding site [chemical binding]; other site 211586006150 Cytochrome C biogenesis protein transmembrane region; Region: DsbD_2; pfam13386 211586006151 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 211586006152 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 211586006153 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 211586006154 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 211586006155 metal-binding site [ion binding] 211586006156 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 211586006157 Soluble P-type ATPase [General function prediction only]; Region: COG4087 211586006158 FixH; Region: FixH; pfam05751 211586006159 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 211586006160 N-terminal domain of cytochrome oxidase-cbb3, FixP; Region: FixP_N; pfam14715 211586006161 Cytochrome c; Region: Cytochrom_C; pfam00034 211586006162 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 211586006163 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 211586006164 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 211586006165 cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488 211586006166 Low-spin heme binding site [chemical binding]; other site 211586006167 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 211586006168 D-pathway; other site 211586006169 Putative water exit pathway; other site 211586006170 Binuclear center (active site) [active] 211586006171 K-pathway; other site 211586006172 Putative proton exit pathway; other site 211586006173 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 211586006174 active site 211586006175 phosphorylation site [posttranslational modification] 211586006176 intermolecular recognition site; other site 211586006177 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 211586006178 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 211586006179 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211586006180 Zn2+ binding site [ion binding]; other site 211586006181 Mg2+ binding site [ion binding]; other site 211586006182 Transposase; Region: HTH_Tnp_1; pfam01527 211586006183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586006184 putative transposase OrfB; Reviewed; Region: PHA02517 211586006185 HTH-like domain; Region: HTH_21; pfam13276 211586006186 Integrase core domain; Region: rve; pfam00665 211586006187 Integrase core domain; Region: rve_2; pfam13333 211586006188 putative transporter; Provisional; Region: PRK11043 211586006189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586006190 putative substrate translocation pore; other site 211586006191 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 211586006192 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586006193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 211586006194 dimerization interface [polypeptide binding]; other site 211586006195 YccA-like proteins; Region: YccA_like; cd10433 211586006196 sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012 211586006197 sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010 211586006198 sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011 211586006199 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 211586006200 DEAD-like helicases superfamily; Region: DEXDc; smart00487 211586006201 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211586006202 ATP binding site [chemical binding]; other site 211586006203 putative Mg++ binding site [ion binding]; other site 211586006204 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586006205 nucleotide binding region [chemical binding]; other site 211586006206 ATP-binding site [chemical binding]; other site 211586006207 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 211586006208 active site 211586006209 DNA binding site [nucleotide binding] 211586006210 Int/Topo IB signature motif; other site 211586006211 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 211586006212 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 211586006213 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 211586006214 DTW domain; Region: DTW; cl01221 211586006215 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 211586006216 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 211586006217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586006218 putative substrate translocation pore; other site 211586006219 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 211586006220 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 211586006221 domain interface [polypeptide binding]; other site 211586006222 putative active site [active] 211586006223 catalytic site [active] 211586006224 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 211586006225 domain interface [polypeptide binding]; other site 211586006226 putative active site [active] 211586006227 catalytic site [active] 211586006228 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 211586006229 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586006230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586006231 Syndecan domain; Region: Syndecan; pfam01034 211586006232 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 211586006233 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 211586006234 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 211586006235 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 211586006236 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 211586006237 active site 211586006238 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 211586006239 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 211586006240 short chain dehydrogenase; Provisional; Region: PRK07576 211586006241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 211586006242 NAD(P) binding site [chemical binding]; other site 211586006243 active site 211586006244 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 211586006245 active site 211586006246 dimer interface [polypeptide binding]; other site 211586006247 tetratricopeptide repeat protein; Provisional; Region: PRK11788 211586006248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586006249 binding surface 211586006250 TPR motif; other site 211586006251 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 211586006252 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 211586006253 dimer interface [polypeptide binding]; other site 211586006254 DNA binding site [nucleotide binding] 211586006255 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 211586006256 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 211586006257 RNA binding site [nucleotide binding]; other site 211586006258 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 211586006259 RNA binding site [nucleotide binding]; other site 211586006260 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 211586006261 RNA binding site [nucleotide binding]; other site 211586006262 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 211586006263 RNA binding site [nucleotide binding]; other site 211586006264 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 211586006265 RNA binding site [nucleotide binding]; other site 211586006266 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 211586006267 RNA binding site [nucleotide binding]; other site 211586006268 cytidylate kinase; Provisional; Region: cmk; PRK00023 211586006269 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 211586006270 CMP-binding site; other site 211586006271 The sites determining sugar specificity; other site 211586006272 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 211586006273 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 211586006274 hinge; other site 211586006275 active site 211586006276 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 211586006277 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 211586006278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586006279 homodimer interface [polypeptide binding]; other site 211586006280 catalytic residue [active] 211586006281 hypothetical protein; Provisional; Region: PRK10977 211586006282 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 211586006283 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 211586006284 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 211586006285 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 211586006286 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586006287 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586006288 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 211586006289 substrate binding pocket [chemical binding]; other site 211586006290 dimerization interface [polypeptide binding]; other site 211586006291 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 211586006292 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 211586006293 catalytic residue [active] 211586006294 DNA gyrase subunit A; Validated; Region: PRK05560 211586006295 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 211586006296 CAP-like domain; other site 211586006297 active site 211586006298 primary dimer interface [polypeptide binding]; other site 211586006299 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 211586006300 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 211586006301 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 211586006302 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 211586006303 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 211586006304 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 211586006305 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 211586006306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586006307 S-adenosylmethionine binding site [chemical binding]; other site 211586006308 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 211586006309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211586006310 active site 211586006311 motif I; other site 211586006312 motif II; other site 211586006313 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 211586006314 ATP cone domain; Region: ATP-cone; pfam03477 211586006315 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 211586006316 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 211586006317 dimer interface [polypeptide binding]; other site 211586006318 putative radical transfer pathway; other site 211586006319 diiron center [ion binding]; other site 211586006320 tyrosyl radical; other site 211586006321 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 211586006322 catalytic loop [active] 211586006323 iron binding site [ion binding]; other site 211586006324 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586006325 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586006326 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 211586006327 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 211586006328 active site 211586006329 FMN binding site [chemical binding]; other site 211586006330 2,4-decadienoyl-CoA binding site; other site 211586006331 catalytic residue [active] 211586006332 4Fe-4S cluster binding site [ion binding]; other site 211586006333 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 211586006334 protease 4; Provisional; Region: PRK10949 211586006335 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 211586006336 tandem repeat interface [polypeptide binding]; other site 211586006337 oligomer interface [polypeptide binding]; other site 211586006338 active site residues [active] 211586006339 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 211586006340 tandem repeat interface [polypeptide binding]; other site 211586006341 oligomer interface [polypeptide binding]; other site 211586006342 active site residues [active] 211586006343 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 211586006344 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 211586006345 active site 211586006346 homodimer interface [polypeptide binding]; other site 211586006347 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 211586006348 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 211586006349 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 211586006350 putative active site [active] 211586006351 Zn binding site [ion binding]; other site 211586006352 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211586006353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586006354 active site 211586006355 phosphorylation site [posttranslational modification] 211586006356 intermolecular recognition site; other site 211586006357 dimerization interface [polypeptide binding]; other site 211586006358 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211586006359 DNA binding site [nucleotide binding] 211586006360 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 211586006361 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 211586006362 N-terminal plug; other site 211586006363 ligand-binding site [chemical binding]; other site 211586006364 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 211586006365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586006366 Walker A motif; other site 211586006367 ATP binding site [chemical binding]; other site 211586006368 Walker B motif; other site 211586006369 arginine finger; other site 211586006370 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 211586006371 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 211586006372 RuvA N terminal domain; Region: RuvA_N; pfam01330 211586006373 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 211586006374 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 211586006375 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 211586006376 active site 211586006377 putative DNA-binding cleft [nucleotide binding]; other site 211586006378 dimer interface [polypeptide binding]; other site 211586006379 hypothetical protein; Validated; Region: PRK00110 211586006380 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 211586006381 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 211586006382 dimer interface [polypeptide binding]; other site 211586006383 anticodon binding site; other site 211586006384 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 211586006385 homodimer interface [polypeptide binding]; other site 211586006386 motif 1; other site 211586006387 active site 211586006388 motif 2; other site 211586006389 GAD domain; Region: GAD; pfam02938 211586006390 motif 3; other site 211586006391 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211586006392 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211586006393 substrate binding pocket [chemical binding]; other site 211586006394 membrane-bound complex binding site; other site 211586006395 hinge residues; other site 211586006396 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211586006397 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211586006398 substrate binding pocket [chemical binding]; other site 211586006399 membrane-bound complex binding site; other site 211586006400 hinge residues; other site 211586006401 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211586006402 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211586006403 substrate binding pocket [chemical binding]; other site 211586006404 membrane-bound complex binding site; other site 211586006405 hinge residues; other site 211586006406 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586006407 metal binding site [ion binding]; metal-binding site 211586006408 active site 211586006409 I-site; other site 211586006410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586006411 S-adenosylmethionine binding site [chemical binding]; other site 211586006412 tRNA (mo5U34)-methyltransferase; Region: TIGR00452 211586006413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586006414 S-adenosylmethionine binding site [chemical binding]; other site 211586006415 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 211586006416 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586006417 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586006418 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 211586006419 dimerization interface [polypeptide binding]; other site 211586006420 SprA-related family; Region: SprA-related; pfam12118 211586006421 lysyl-tRNA synthetase; Provisional; Region: PTZ00385 211586006422 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 211586006423 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211586006424 FeS/SAM binding site; other site 211586006425 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 211586006426 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 211586006427 ThiS interaction site; other site 211586006428 putative active site [active] 211586006429 tetramer interface [polypeptide binding]; other site 211586006430 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 211586006431 thiS-thiF/thiG interaction site; other site 211586006432 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 211586006433 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 211586006434 ATP binding site [chemical binding]; other site 211586006435 substrate interface [chemical binding]; other site 211586006436 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 211586006437 HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898 211586006438 dimer interface [polypeptide binding]; other site 211586006439 substrate binding site [chemical binding]; other site 211586006440 ATP binding site [chemical binding]; other site 211586006441 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 211586006442 active site 211586006443 thiamine phosphate binding site [chemical binding]; other site 211586006444 pyrophosphate binding site [ion binding]; other site 211586006445 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 211586006446 ThiC-associated domain; Region: ThiC-associated; pfam13667 211586006447 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 211586006448 Haemolysin-III related; Region: HlyIII; cl03831 211586006449 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 211586006450 nudix motif; other site 211586006451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 211586006452 Glycosyl-hydrolase 97 N-terminal; Region: GH97_N; pfam14508 211586006453 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 211586006454 Glycosyl-hydrolase 97 C-terminal, oligomerization; Region: GH97_C; pfam14509 211586006455 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 211586006456 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 211586006457 putative RNA binding site [nucleotide binding]; other site 211586006458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586006459 S-adenosylmethionine binding site [chemical binding]; other site 211586006460 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 211586006461 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 211586006462 putative NAD(P) binding site [chemical binding]; other site 211586006463 substrate binding site [chemical binding]; other site 211586006464 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 211586006465 FMN binding site [chemical binding]; other site 211586006466 active site 211586006467 substrate binding site [chemical binding]; other site 211586006468 catalytic residue [active] 211586006469 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 211586006470 FMN binding site [chemical binding]; other site 211586006471 active site 211586006472 substrate binding site [chemical binding]; other site 211586006473 catalytic residue [active] 211586006474 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586006475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586006476 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 211586006477 putative effector binding pocket; other site 211586006478 dimerization interface [polypeptide binding]; other site 211586006479 YCII-related domain; Region: YCII; cl00999 211586006480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586006481 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 211586006482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586006483 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 211586006484 Domain interface; other site 211586006485 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 211586006486 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 211586006487 Transposase; Region: HTH_Tnp_1; pfam01527 211586006488 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586006489 putative transposase OrfB; Reviewed; Region: PHA02517 211586006490 HTH-like domain; Region: HTH_21; pfam13276 211586006491 Integrase core domain; Region: rve; pfam00665 211586006492 Integrase core domain; Region: rve_2; pfam13333 211586006493 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 211586006494 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 211586006495 N-terminal plug; other site 211586006496 ligand-binding site [chemical binding]; other site 211586006497 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 211586006498 putative catalytic residues [active] 211586006499 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 211586006500 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 211586006501 metal binding site [ion binding]; metal-binding site 211586006502 dimer interface [polypeptide binding]; other site 211586006503 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 211586006504 Putative lysophospholipase; Region: Hydrolase_4; cl19140 211586006505 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 211586006506 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 211586006507 active site clefts [active] 211586006508 zinc binding site [ion binding]; other site 211586006509 dimer interface [polypeptide binding]; other site 211586006510 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 211586006511 inhibitor-cofactor binding pocket; inhibition site 211586006512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586006513 catalytic residue [active] 211586006514 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH3; cd08184 211586006515 putative active site [active] 211586006516 metal binding site [ion binding]; metal-binding site 211586006517 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 211586006518 Ligand binding site; other site 211586006519 oligomer interface; other site 211586006520 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 211586006521 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 211586006522 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 211586006523 aminotransferase AlaT; Validated; Region: PRK09265 211586006524 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 211586006525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586006526 homodimer interface [polypeptide binding]; other site 211586006527 catalytic residue [active] 211586006528 5'-nucleotidase; Provisional; Region: PRK03826 211586006529 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 211586006530 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211586006531 Zn2+ binding site [ion binding]; other site 211586006532 Mg2+ binding site [ion binding]; other site 211586006533 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 211586006534 Entner-Doudoroff aldolase; Region: eda; TIGR01182 211586006535 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 211586006536 active site 211586006537 intersubunit interface [polypeptide binding]; other site 211586006538 catalytic residue [active] 211586006539 phosphogluconate dehydratase; Validated; Region: PRK09054 211586006540 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 211586006541 putative active site [active] 211586006542 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 211586006543 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 211586006544 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 211586006545 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 211586006546 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 211586006547 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 211586006548 putative active site [active] 211586006549 pyruvate kinase; Provisional; Region: PRK05826 211586006550 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 211586006551 domain interfaces; other site 211586006552 active site 211586006553 acyl-CoA dehydrogenase; Reviewed; Region: PRK13026 211586006554 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 211586006555 active site 211586006556 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 211586006557 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 211586006558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211586006559 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 211586006560 active site 211586006561 Zn binding site [ion binding]; other site 211586006562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 211586006563 Smr domain; Region: Smr; pfam01713 211586006564 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 211586006565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 211586006566 SEC-C motif; Region: SEC-C; cl19389 211586006567 SEC-C motif; Region: SEC-C; cl19389 211586006568 GAF domain; Region: GAF; pfam01590 211586006569 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 211586006570 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586006571 putative active site [active] 211586006572 heme pocket [chemical binding]; other site 211586006573 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586006574 metal binding site [ion binding]; metal-binding site 211586006575 active site 211586006576 I-site; other site 211586006577 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586006578 Protein of unknown function (DUF406); Region: DUF406; pfam04175 211586006579 Ribosomal S4P (gammaproteobacterial); Region: Ribosomal_S4Pg; pfam11993 211586006580 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 211586006581 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 211586006582 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 211586006583 Ligand Binding Site [chemical binding]; other site 211586006584 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 211586006585 excinuclease ABC subunit B; Provisional; Region: PRK05298 211586006586 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211586006587 ATP binding site [chemical binding]; other site 211586006588 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586006589 nucleotide binding region [chemical binding]; other site 211586006590 ATP-binding site [chemical binding]; other site 211586006591 Ultra-violet resistance protein B; Region: UvrB; pfam12344 211586006592 UvrB/uvrC motif; Region: UVR; pfam02151 211586006593 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 211586006594 metal binding site [ion binding]; metal-binding site 211586006595 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586006596 electron transport complex protein RsxA; Provisional; Region: PRK05151 211586006597 electron transport complex protein RnfB; Provisional; Region: PRK05113 211586006598 Putative Fe-S cluster; Region: FeS; pfam04060 211586006599 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 211586006600 electron transport complex protein RnfC; Provisional; Region: PRK05035 211586006601 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 211586006602 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 211586006603 SLBB domain; Region: SLBB; pfam10531 211586006604 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 211586006605 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 211586006606 electron transport complex protein RnfG; Validated; Region: PRK01908 211586006607 electron transport complex RsxE subunit; Provisional; Region: PRK12405 211586006608 endonuclease III; Provisional; Region: PRK10702 211586006609 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 211586006610 minor groove reading motif; other site 211586006611 helix-hairpin-helix signature motif; other site 211586006612 substrate binding pocket [chemical binding]; other site 211586006613 active site 211586006614 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 211586006615 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 211586006616 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 211586006617 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586006618 metal binding site [ion binding]; metal-binding site 211586006619 active site 211586006620 I-site; other site 211586006621 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 211586006622 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 211586006623 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 211586006624 N-terminal plug; other site 211586006625 ligand-binding site [chemical binding]; other site 211586006626 Phytase; Region: Phytase; cl17685 211586006627 Phytase; Region: Phytase; cl17685 211586006628 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 211586006629 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 211586006630 ABC transporter; Region: ABC_tran_2; pfam12848 211586006631 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 211586006632 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 211586006633 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 211586006634 active site 211586006635 DNA binding site [nucleotide binding] 211586006636 Int/Topo IB signature motif; other site 211586006637 rhombotail lipoprotein; Region: rhombo_lipo; TIGR04179 211586006638 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 211586006639 active site 211586006640 catalytic residues [active] 211586006641 metal binding site [ion binding]; metal-binding site 211586006642 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 211586006643 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 211586006644 active site 211586006645 DNA binding site [nucleotide binding] 211586006646 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 211586006647 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 211586006648 putative active site [active] 211586006649 Glutamine amidotransferases class-II; Region: GATase_2; pfam00310 211586006650 putative dimer interface [polypeptide binding]; other site 211586006651 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 211586006652 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 211586006653 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 211586006654 active site 211586006655 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 211586006656 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 211586006657 TrkA-N domain; Region: TrkA_N; pfam02254 211586006658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586006659 active site 211586006660 phosphorylation site [posttranslational modification] 211586006661 intermolecular recognition site; other site 211586006662 dimerization interface [polypeptide binding]; other site 211586006663 HDOD domain; Region: HDOD; pfam08668 211586006664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586006665 active site 211586006666 phosphorylation site [posttranslational modification] 211586006667 intermolecular recognition site; other site 211586006668 dimerization interface [polypeptide binding]; other site 211586006669 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586006670 PAS domain; Region: PAS_9; pfam13426 211586006671 putative active site [active] 211586006672 heme pocket [chemical binding]; other site 211586006673 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586006674 Helix-turn-helix domain; Region: HTH_17; pfam12728 211586006675 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211586006676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586006677 active site 211586006678 phosphorylation site [posttranslational modification] 211586006679 intermolecular recognition site; other site 211586006680 dimerization interface [polypeptide binding]; other site 211586006681 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 211586006682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586006683 active site 211586006684 phosphorylation site [posttranslational modification] 211586006685 intermolecular recognition site; other site 211586006686 dimerization interface [polypeptide binding]; other site 211586006687 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211586006688 Zn2+ binding site [ion binding]; other site 211586006689 Mg2+ binding site [ion binding]; other site 211586006690 FIST N domain; Region: FIST; pfam08495 211586006691 FIST C domain; Region: FIST_C; pfam10442 211586006692 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211586006693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586006694 dimer interface [polypeptide binding]; other site 211586006695 phosphorylation site [posttranslational modification] 211586006696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586006697 ATP binding site [chemical binding]; other site 211586006698 Mg2+ binding site [ion binding]; other site 211586006699 G-X-G motif; other site 211586006700 Carbon starvation protein CstA; Region: CstA; pfam02554 211586006701 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211586006702 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586006703 dimer interface [polypeptide binding]; other site 211586006704 phosphorylation site [posttranslational modification] 211586006705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586006706 ATP binding site [chemical binding]; other site 211586006707 Mg2+ binding site [ion binding]; other site 211586006708 G-X-G motif; other site 211586006709 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211586006710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586006711 active site 211586006712 phosphorylation site [posttranslational modification] 211586006713 intermolecular recognition site; other site 211586006714 dimerization interface [polypeptide binding]; other site 211586006715 Hpt domain; Region: Hpt; pfam01627 211586006716 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 211586006717 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586006718 dimer interface [polypeptide binding]; other site 211586006719 phosphorylation site [posttranslational modification] 211586006720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586006721 ATP binding site [chemical binding]; other site 211586006722 Mg2+ binding site [ion binding]; other site 211586006723 G-X-G motif; other site 211586006724 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 211586006725 CheC-like family; Region: CheC; pfam04509 211586006726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586006727 active site 211586006728 phosphorylation site [posttranslational modification] 211586006729 intermolecular recognition site; other site 211586006730 dimerization interface [polypeptide binding]; other site 211586006731 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 211586006732 BON domain; Region: BON; pfam04972 211586006733 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 211586006734 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 211586006735 ligand binding site [chemical binding]; other site 211586006736 flexible hinge region; other site 211586006737 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 211586006738 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 211586006739 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 211586006740 ligand binding site [chemical binding]; other site 211586006741 flexible hinge region; other site 211586006742 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 211586006743 non-specific DNA interactions [nucleotide binding]; other site 211586006744 DNA binding site [nucleotide binding] 211586006745 sequence specific DNA binding site [nucleotide binding]; other site 211586006746 putative cAMP binding site [chemical binding]; other site 211586006747 CsbD-like; Region: CsbD; cl17424 211586006748 BON domain; Region: BON; pfam04972 211586006749 BON domain; Region: BON; pfam04972 211586006750 BON domain; Region: BON; pfam04972 211586006751 TIGR03503 family protein; Region: TIGR03503 211586006752 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 211586006753 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 211586006754 active site 211586006755 catalytic site [active] 211586006756 substrate binding site [chemical binding]; other site 211586006757 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 211586006758 RNA/DNA hybrid binding site [nucleotide binding]; other site 211586006759 active site 211586006760 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 211586006761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586006762 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 211586006763 dimerization interface [polypeptide binding]; other site 211586006764 Methyltransferase domain; Region: Methyltransf_11; pfam08241 211586006765 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 211586006766 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 211586006767 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 211586006768 N-acetyl-D-glucosamine binding site [chemical binding]; other site 211586006769 catalytic residue [active] 211586006770 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 211586006771 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 211586006772 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 211586006773 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 211586006774 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 211586006775 AsmA family; Region: AsmA; pfam05170 211586006776 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 211586006777 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 211586006778 ribonuclease activity regulator protein RraA; Reviewed; Region: PRK12487 211586006779 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 211586006780 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 211586006781 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 211586006782 ATP binding site [chemical binding]; other site 211586006783 Mg++ binding site [ion binding]; other site 211586006784 motif III; other site 211586006785 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586006786 nucleotide binding region [chemical binding]; other site 211586006787 ATP-binding site [chemical binding]; other site 211586006788 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 211586006789 substrate binding site [chemical binding]; other site 211586006790 hypothetical protein; Provisional; Region: PRK05170 211586006791 YcgL domain; Region: YcgL; pfam05166 211586006792 septum formation inhibitor; Reviewed; Region: minC; PRK04804 211586006793 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 211586006794 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 211586006795 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 211586006796 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 211586006797 P-loop; other site 211586006798 ADP binding residues [chemical binding]; other site 211586006799 Switch I; other site 211586006800 Switch II; other site 211586006801 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 211586006802 ribonuclease D; Region: rnd; TIGR01388 211586006803 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 211586006804 catalytic site [active] 211586006805 putative active site [active] 211586006806 putative substrate binding site [chemical binding]; other site 211586006807 HRDC domain; Region: HRDC; pfam00570 211586006808 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 211586006809 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 211586006810 acyl-activating enzyme (AAE) consensus motif; other site 211586006811 putative AMP binding site [chemical binding]; other site 211586006812 putative active site [active] 211586006813 putative CoA binding site [chemical binding]; other site 211586006814 Putative lysophospholipase; Region: Hydrolase_4; cl19140 211586006815 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 211586006816 Predicted methyltransferase [General function prediction only]; Region: COG4798 211586006817 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 211586006818 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 211586006819 Glycoprotease family; Region: Peptidase_M22; pfam00814 211586006820 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 211586006821 dimer interface [polypeptide binding]; other site 211586006822 active site 211586006823 Schiff base residues; other site 211586006824 Transposase IS200 like; Region: Y1_Tnp; pfam01797 211586006825 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 211586006826 SelR domain; Region: SelR; cl15841 211586006827 methionine sulfoxide reductase A; Provisional; Region: PRK14054 211586006828 aminocyclopropanecarboxylate oxidase; Region: PLN02403 211586006829 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 211586006830 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 211586006831 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 211586006832 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 211586006833 GTP/Mg2+ binding site [chemical binding]; other site 211586006834 G4 box; other site 211586006835 G5 box; other site 211586006836 G1 box; other site 211586006837 Switch I region; other site 211586006838 G2 box; other site 211586006839 G3 box; other site 211586006840 Switch II region; other site 211586006841 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 211586006842 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 211586006843 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 211586006844 quinone interaction residues [chemical binding]; other site 211586006845 active site 211586006846 catalytic residues [active] 211586006847 FMN binding site [chemical binding]; other site 211586006848 substrate binding site [chemical binding]; other site 211586006849 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 211586006850 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 211586006851 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 211586006852 MMPL family; Region: MMPL; cl14618 211586006853 MMPL family; Region: MMPL; cl14618 211586006854 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 211586006855 Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870 211586006856 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 211586006857 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 211586006858 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 211586006859 aminopeptidase N; Provisional; Region: pepN; PRK14015 211586006860 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 211586006861 Zn binding site [ion binding]; other site 211586006862 carboxy-terminal protease; Provisional; Region: PRK11186 211586006863 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 211586006864 protein binding site [polypeptide binding]; other site 211586006865 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 211586006866 Catalytic dyad [active] 211586006867 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 211586006868 ProP expression regulator; Provisional; Region: PRK04950 211586006869 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 211586006870 YebG protein; Region: YebG; pfam07130 211586006871 Paraquat-inducible protein A; Region: PqiA; pfam04403 211586006872 Paraquat-inducible protein A; Region: PqiA; pfam04403 211586006873 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 211586006874 mce related protein; Region: MCE; pfam02470 211586006875 mce related protein; Region: MCE; pfam02470 211586006876 mce related protein; Region: MCE; pfam02470 211586006877 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 211586006878 mce related protein; Region: MCE; pfam02470 211586006879 mce related protein; Region: MCE; pfam02470 211586006880 mce related protein; Region: MCE; pfam02470 211586006881 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 211586006882 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 211586006883 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 211586006884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586006885 S-adenosylmethionine binding site [chemical binding]; other site 211586006886 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 211586006887 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 211586006888 active site 211586006889 PilZ domain; Region: PilZ; cl01260 211586006890 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 211586006891 DNA polymerase III subunit delta'; Validated; Region: PRK08485 211586006892 thymidylate kinase; Validated; Region: tmk; PRK00698 211586006893 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 211586006894 TMP-binding site; other site 211586006895 ATP-binding site [chemical binding]; other site 211586006896 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 211586006897 dimerization interface [polypeptide binding]; other site 211586006898 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 211586006899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586006900 catalytic residue [active] 211586006901 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 211586006902 trimer interface [polypeptide binding]; other site 211586006903 active site 211586006904 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 211586006905 ATP-binding site [chemical binding]; other site 211586006906 Sugar specificity; other site 211586006907 Pyrimidine base specificity; other site 211586006908 antiporter inner membrane protein; Provisional; Region: PRK11670 211586006909 Domain of unknown function DUF59; Region: DUF59; cl00941 211586006910 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 211586006911 Walker A motif; other site 211586006912 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 211586006913 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 211586006914 active site 211586006915 HIGH motif; other site 211586006916 KMSKS motif; other site 211586006917 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 211586006918 tRNA binding surface [nucleotide binding]; other site 211586006919 anticodon binding site; other site 211586006920 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 211586006921 dimer interface [polypeptide binding]; other site 211586006922 putative tRNA-binding site [nucleotide binding]; other site 211586006923 Predicted permeases [General function prediction only]; Region: COG0679 211586006924 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 211586006925 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 211586006926 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 211586006927 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 211586006928 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 211586006929 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 211586006930 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 211586006931 rRNA binding site [nucleotide binding]; other site 211586006932 predicted 30S ribosome binding site; other site 211586006933 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 211586006934 Clp amino terminal domain; Region: Clp_N; pfam02861 211586006935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586006936 Walker A motif; other site 211586006937 ATP binding site [chemical binding]; other site 211586006938 Walker B motif; other site 211586006939 arginine finger; other site 211586006940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586006941 Walker A motif; other site 211586006942 ATP binding site [chemical binding]; other site 211586006943 Walker B motif; other site 211586006944 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 211586006945 Uncharacterized conserved protein [Function unknown]; Region: COG2127 211586006946 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 211586006947 DNA-binding site [nucleotide binding]; DNA binding site 211586006948 RNA-binding motif; other site 211586006949 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 211586006950 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 211586006951 probable active site [active] 211586006952 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 211586006953 nudix motif; other site 211586006954 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 211586006955 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 211586006956 Ligand Binding Site [chemical binding]; other site 211586006957 putative lysogenization regulator; Reviewed; Region: PRK00218 211586006958 adenylosuccinate lyase; Provisional; Region: PRK09285 211586006959 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 211586006960 tetramer interface [polypeptide binding]; other site 211586006961 active site 211586006962 Cupin superfamily protein; Region: Cupin_4; pfam08007 211586006963 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 211586006964 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 211586006965 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 211586006966 NAD binding site [chemical binding]; other site 211586006967 Phe binding site; other site 211586006968 Transcriptional regulators [Transcription]; Region: MarR; COG1846 211586006969 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 211586006970 Protein of unknown function (DUF1285); Region: DUF1285; cl19847 211586006971 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 211586006972 FAD binding domain; Region: FAD_binding_4; pfam01565 211586006973 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 211586006974 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 211586006975 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 211586006976 phosphoenolpyruvate synthase; Validated; Region: PRK06464 211586006977 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 211586006978 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 211586006979 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 211586006980 PEP synthetase regulatory protein; Provisional; Region: PRK05339 211586006981 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 211586006982 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 211586006983 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 211586006984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586006985 active site 211586006986 phosphorylation site [posttranslational modification] 211586006987 intermolecular recognition site; other site 211586006988 dimerization interface [polypeptide binding]; other site 211586006989 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 211586006990 DNA binding residues [nucleotide binding] 211586006991 dimerization interface [polypeptide binding]; other site 211586006992 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 211586006993 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586006994 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 211586006995 substrate binding site [chemical binding]; other site 211586006996 dimerization interface [polypeptide binding]; other site 211586006997 prophage MuSo2 211586006998 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 211586006999 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211586007000 salt bridge; other site 211586007001 non-specific DNA binding site [nucleotide binding]; other site 211586007002 sequence-specific DNA binding site [nucleotide binding]; other site 211586007003 Predicted transcriptional regulator [Transcription]; Region: COG2932 211586007004 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 211586007005 Catalytic site [active] 211586007006 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 211586007007 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 211586007008 Mu DNA binding, I gamma subdomain; Region: HTH_Tnp_Mu_2; pfam09039 211586007009 Bacteriophage Mu transposase; Region: DDE_2; pfam02914 211586007010 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 211586007011 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 211586007012 AAA domain; Region: AAA_22; pfam13401 211586007013 Mu B transposition protein, C terminal; Region: Phage-MuB_C; pfam09077 211586007014 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 211586007015 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 211586007016 Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012 211586007017 Protein of unknown function (DUF1018); Region: DUF1018; pfam06252 211586007018 Mor transcription activator family; Region: Mor; pfam08765 211586007019 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 211586007020 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 211586007021 Purine nucleoside permease (NUP); Region: NUP; cl17832 211586007022 phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419 211586007023 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805 211586007024 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 211586007025 Phage Terminase; Region: Terminase_1; cl19862 211586007026 Terminase-like family; Region: Terminase_6; pfam03237 211586007027 Protein of unknown function (DUF935); Region: DUF935; pfam06074 211586007028 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 211586007029 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 211586007030 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 211586007031 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; pfam10124 211586007032 Protein of unknown function (DUF1320); Region: DUF1320; pfam07030 211586007033 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 211586007034 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 211586007035 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 211586007036 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 211586007037 Phage tail tube protein; Region: Tail_tube; pfam10618 211586007038 Mu-like prophage FluMu protein gp41 [Function unknown]; Region: COG4518 211586007039 Mu-like prophage protein [General function prediction only]; Region: COG3941 211586007040 tape measure domain; Region: tape_meas_nterm; TIGR02675 211586007041 DNA circularisation protein N-terminus; Region: DNA_circ_N; pfam07157 211586007042 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 211586007043 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890 211586007044 Phage protein GP46; Region: GP46; pfam07409 211586007045 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 211586007046 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 211586007047 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 211586007048 active site 211586007049 oxyanion hole [active] 211586007050 catalytic triad [active] 211586007051 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 211586007052 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 211586007053 active site 211586007054 interdomain interaction site; other site 211586007055 putative metal-binding site [ion binding]; other site 211586007056 nucleotide binding site [chemical binding]; other site 211586007057 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 211586007058 domain I; other site 211586007059 DNA binding groove [nucleotide binding] 211586007060 phosphate binding site [ion binding]; other site 211586007061 domain II; other site 211586007062 domain III; other site 211586007063 nucleotide binding site [chemical binding]; other site 211586007064 catalytic site [active] 211586007065 domain IV; other site 211586007066 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 211586007067 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 211586007068 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 211586007069 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 211586007070 succinylarginine dihydrolase; Provisional; Region: PRK13281 211586007071 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 211586007072 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 211586007073 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 211586007074 putative FMN binding site [chemical binding]; other site 211586007075 DoxX; Region: DoxX; pfam07681 211586007076 Phosphotransferase enzyme family; Region: APH; pfam01636 211586007077 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 211586007078 substrate binding site [chemical binding]; other site 211586007079 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 211586007080 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 211586007081 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 211586007082 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 211586007083 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 211586007084 ligand binding site [chemical binding]; other site 211586007085 flexible hinge region; other site 211586007086 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 211586007087 putative transporter; Provisional; Region: PRK03699 211586007088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586007089 putative substrate translocation pore; other site 211586007090 purine nucleoside phosphorylase; Provisional; Region: PRK13374 211586007091 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 211586007092 putative dimer interface [polypeptide binding]; other site 211586007093 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 211586007094 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 211586007095 CoenzymeA binding site [chemical binding]; other site 211586007096 subunit interaction site [polypeptide binding]; other site 211586007097 PHB binding site; other site 211586007098 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 211586007099 CoenzymeA binding site [chemical binding]; other site 211586007100 subunit interaction site [polypeptide binding]; other site 211586007101 PHB binding site; other site 211586007102 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 211586007103 nucleotide binding site/active site [active] 211586007104 HIT family signature motif; other site 211586007105 catalytic residue [active] 211586007106 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 211586007107 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 211586007108 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 211586007109 Zn binding site [ion binding]; other site 211586007110 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 211586007111 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 211586007112 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 211586007113 DNA binding residues [nucleotide binding] 211586007114 dimerization interface [polypeptide binding]; other site 211586007115 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 211586007116 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 211586007117 heat shock protein HtpX; Provisional; Region: PRK05457 211586007118 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 211586007119 active site pocket [active] 211586007120 oxyanion hole [active] 211586007121 catalytic triad [active] 211586007122 active site nucleophile [active] 211586007123 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 211586007124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 211586007125 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 211586007126 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586007127 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 211586007128 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 211586007129 Transposase; Region: HTH_Tnp_1; pfam01527 211586007130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586007131 putative transposase OrfB; Reviewed; Region: PHA02517 211586007132 HTH-like domain; Region: HTH_21; pfam13276 211586007133 Integrase core domain; Region: rve; pfam00665 211586007134 Integrase core domain; Region: rve_2; pfam13333 211586007135 Protein of unknown function (DUF3187); Region: DUF3187; pfam11383 211586007136 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 211586007137 AAA domain; Region: AAA_26; pfam13500 211586007138 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 211586007139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586007140 S-adenosylmethionine binding site [chemical binding]; other site 211586007141 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 211586007142 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 211586007143 substrate-cofactor binding pocket; other site 211586007144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586007145 catalytic residue [active] 211586007146 biotin synthase; Provisional; Region: PRK15108 211586007147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211586007148 FeS/SAM binding site; other site 211586007149 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 211586007150 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 211586007151 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 211586007152 inhibitor-cofactor binding pocket; inhibition site 211586007153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586007154 catalytic residue [active] 211586007155 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 211586007156 Na binding site [ion binding]; other site 211586007157 PAS domain; Region: PAS; smart00091 211586007158 PAS fold; Region: PAS_7; pfam12860 211586007159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586007160 dimer interface [polypeptide binding]; other site 211586007161 phosphorylation site [posttranslational modification] 211586007162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586007163 ATP binding site [chemical binding]; other site 211586007164 Mg2+ binding site [ion binding]; other site 211586007165 G-X-G motif; other site 211586007166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586007167 active site 211586007168 phosphorylation site [posttranslational modification] 211586007169 intermolecular recognition site; other site 211586007170 dimerization interface [polypeptide binding]; other site 211586007171 acetyl-CoA synthetase; Provisional; Region: PRK00174 211586007172 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 211586007173 active site 211586007174 CoA binding site [chemical binding]; other site 211586007175 acyl-activating enzyme (AAE) consensus motif; other site 211586007176 AMP binding site [chemical binding]; other site 211586007177 acetate binding site [chemical binding]; other site 211586007178 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 211586007179 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211586007180 ATP binding site [chemical binding]; other site 211586007181 putative Mg++ binding site [ion binding]; other site 211586007182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586007183 nucleotide binding region [chemical binding]; other site 211586007184 ATP-binding site [chemical binding]; other site 211586007185 Double zinc ribbon; Region: DZR; pfam12773 211586007186 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 211586007187 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 211586007188 GSH binding site [chemical binding]; other site 211586007189 catalytic residues [active] 211586007190 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 211586007191 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586007192 binding surface 211586007193 TPR motif; other site 211586007194 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 211586007195 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 211586007196 ligand binding site [chemical binding]; other site 211586007197 translocation protein TolB; Provisional; Region: tolB; PRK04792 211586007198 TolB amino-terminal domain; Region: TolB_N; pfam04052 211586007199 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 211586007200 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 211586007201 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 211586007202 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 211586007203 TolA protein; Region: tolA_full; TIGR02794 211586007204 Protein of unknown function (DUF3807); Region: DUF3807; pfam12720 211586007205 TolA C-terminal; Region: TolA; pfam06519 211586007206 TolR protein; Region: tolR; TIGR02801 211586007207 TolQ protein; Region: tolQ; TIGR02796 211586007208 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 211586007209 active site 211586007210 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 211586007211 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 211586007212 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 211586007213 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 211586007214 ligand binding site [chemical binding]; other site 211586007215 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 211586007216 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 211586007217 dimer interface [polypeptide binding]; other site 211586007218 catalytic site [active] 211586007219 putative active site [active] 211586007220 putative substrate binding site [chemical binding]; other site 211586007221 peroxidase; Provisional; Region: PRK15000 211586007222 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 211586007223 dimer interface [polypeptide binding]; other site 211586007224 decamer (pentamer of dimers) interface [polypeptide binding]; other site 211586007225 catalytic triad [active] 211586007226 peroxidatic and resolving cysteines [active] 211586007227 Predicted permease [General function prediction only]; Region: COG2056 211586007228 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 211586007229 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 211586007230 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586007231 metal binding site [ion binding]; metal-binding site 211586007232 active site 211586007233 I-site; other site 211586007234 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211586007235 active site 211586007236 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 211586007237 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 211586007238 dimerization interface [polypeptide binding]; other site 211586007239 putative ATP binding site [chemical binding]; other site 211586007240 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 211586007241 active site 211586007242 substrate binding site [chemical binding]; other site 211586007243 cosubstrate binding site; other site 211586007244 catalytic site [active] 211586007245 UMP phosphatase; Provisional; Region: PRK10444 211586007246 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211586007247 active site 211586007248 motif I; other site 211586007249 motif II; other site 211586007250 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137 211586007251 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 211586007252 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 211586007253 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 211586007254 PA/protease or protease-like domain interface [polypeptide binding]; other site 211586007255 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 211586007256 metal binding site [ion binding]; metal-binding site 211586007257 asparagine synthetase B; Provisional; Region: asnB; PRK09431 211586007258 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 211586007259 active site 211586007260 dimer interface [polypeptide binding]; other site 211586007261 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 211586007262 Ligand Binding Site [chemical binding]; other site 211586007263 Molecular Tunnel; other site 211586007264 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 211586007265 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 211586007266 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 211586007267 active site 211586007268 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 211586007269 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 211586007270 active site 211586007271 phosphate binding residues; other site 211586007272 catalytic residues [active] 211586007273 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 211586007274 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 211586007275 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 211586007276 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 211586007277 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 211586007278 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 211586007279 dimer interface [polypeptide binding]; other site 211586007280 active site 211586007281 acyl carrier protein; Provisional; Region: acpP; PRK00982 211586007282 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 211586007283 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 211586007284 NAD(P) binding site [chemical binding]; other site 211586007285 homotetramer interface [polypeptide binding]; other site 211586007286 homodimer interface [polypeptide binding]; other site 211586007287 active site 211586007288 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 211586007289 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 211586007290 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 211586007291 dimer interface [polypeptide binding]; other site 211586007292 active site 211586007293 CoA binding pocket [chemical binding]; other site 211586007294 putative phosphate acyltransferase; Provisional; Region: PRK05331 211586007295 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 211586007296 hypothetical protein; Provisional; Region: PRK11193 211586007297 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 211586007298 active site 211586007299 dimer interface [polypeptide binding]; other site 211586007300 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 211586007301 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211586007302 RNA binding surface [nucleotide binding]; other site 211586007303 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 211586007304 active site 211586007305 ribonuclease E; Reviewed; Region: rne; PRK10811 211586007306 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 211586007307 homodimer interface [polypeptide binding]; other site 211586007308 oligonucleotide binding site [chemical binding]; other site 211586007309 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 211586007310 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 211586007311 DNA-binding site [nucleotide binding]; DNA binding site 211586007312 RNA-binding motif; other site 211586007313 Methyltransferase domain; Region: Methyltransf_31; pfam13847 211586007314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586007315 S-adenosylmethionine binding site [chemical binding]; other site 211586007316 exonuclease I; Provisional; Region: sbcB; PRK11779 211586007317 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 211586007318 active site 211586007319 catalytic site [active] 211586007320 substrate binding site [chemical binding]; other site 211586007321 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 211586007322 cytidine deaminase; Provisional; Region: PRK09027 211586007323 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 211586007324 active site 211586007325 catalytic motif [active] 211586007326 Zn binding site [ion binding]; other site 211586007327 Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211 211586007328 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 211586007329 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 211586007330 Protein of unknown function (DUF445); Region: DUF445; pfam04286 211586007331 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 211586007332 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 211586007333 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 211586007334 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 211586007335 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 211586007336 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 211586007337 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 211586007338 Predicted membrane protein [Function unknown]; Region: COG3235 211586007339 Uncharacterized conserved protein [Function unknown]; Region: COG2835 211586007340 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 211586007341 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 211586007342 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211586007343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211586007344 Walker A/P-loop; other site 211586007345 ATP binding site [chemical binding]; other site 211586007346 Q-loop/lid; other site 211586007347 ABC transporter signature motif; other site 211586007348 Walker B; other site 211586007349 D-loop; other site 211586007350 H-loop/switch region; other site 211586007351 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 211586007352 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 211586007353 Competence protein; Region: Competence; pfam03772 211586007354 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 211586007355 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 211586007356 NnrS protein; Region: NnrS; pfam05940 211586007357 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 211586007358 PilZ domain; Region: PilZ; pfam07238 211586007359 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 211586007360 ParA-like protein; Provisional; Region: PHA02518 211586007361 Magnesium ion binding site [ion binding]; other site 211586007362 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586007363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586007364 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 211586007365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 211586007366 NAD(P) binding site [chemical binding]; other site 211586007367 active site 211586007368 Domain of unknown function DUF21; Region: DUF21; pfam01595 211586007369 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 211586007370 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 211586007371 Transporter associated domain; Region: CorC_HlyC; smart01091 211586007372 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586007373 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586007374 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 211586007375 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 211586007376 Protein of unknown function (DUF2492); Region: DUF2492; pfam10678 211586007377 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 211586007378 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 211586007379 GAF domain; Region: GAF; pfam01590 211586007380 Histidine kinase; Region: His_kinase; pfam06580 211586007381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586007382 ATP binding site [chemical binding]; other site 211586007383 Mg2+ binding site [ion binding]; other site 211586007384 G-X-G motif; other site 211586007385 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 211586007386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586007387 active site 211586007388 phosphorylation site [posttranslational modification] 211586007389 intermolecular recognition site; other site 211586007390 dimerization interface [polypeptide binding]; other site 211586007391 LytTr DNA-binding domain; Region: LytTR; pfam04397 211586007392 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 211586007393 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 211586007394 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 211586007395 dimerization interface [polypeptide binding]; other site 211586007396 active site 211586007397 hypothetical protein; Provisional; Region: PRK11020 211586007398 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 211586007399 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211586007400 FeS/SAM binding site; other site 211586007401 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 211586007402 ATP cone domain; Region: ATP-cone; pfam03477 211586007403 Class III ribonucleotide reductase; Region: RNR_III; cd01675 211586007404 effector binding site; other site 211586007405 active site 211586007406 Zn binding site [ion binding]; other site 211586007407 glycine loop; other site 211586007408 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 211586007409 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 211586007410 active site 211586007411 nucleophile elbow; other site 211586007412 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 211586007413 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 211586007414 ATP binding site [chemical binding]; other site 211586007415 Mg++ binding site [ion binding]; other site 211586007416 motif III; other site 211586007417 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586007418 nucleotide binding region [chemical binding]; other site 211586007419 ATP-binding site [chemical binding]; other site 211586007420 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 211586007421 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 211586007422 phytoene desaturase; Region: phytoene_desat; TIGR02731 211586007423 putative peptidase; Provisional; Region: PRK11649 211586007424 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 211586007425 Peptidase family M23; Region: Peptidase_M23; pfam01551 211586007426 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 211586007427 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 211586007428 Walker A/P-loop; other site 211586007429 ATP binding site [chemical binding]; other site 211586007430 Q-loop/lid; other site 211586007431 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 211586007432 ABC transporter signature motif; other site 211586007433 Walker B; other site 211586007434 D-loop; other site 211586007435 H-loop/switch region; other site 211586007436 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 211586007437 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 211586007438 active site 211586007439 metal binding site [ion binding]; metal-binding site 211586007440 DNA binding site [nucleotide binding] 211586007441 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 211586007442 hypothetical protein; Provisional; Region: PRK10621 211586007443 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 211586007444 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586007445 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 211586007446 dimerization interface [polypeptide binding]; other site 211586007447 substrate binding pocket [chemical binding]; other site 211586007448 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586007449 Coenzyme A binding pocket [chemical binding]; other site 211586007450 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 211586007451 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 211586007452 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 211586007453 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 211586007454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211586007455 active site 211586007456 motif I; other site 211586007457 motif II; other site 211586007458 Transcriptional regulators [Transcription]; Region: GntR; COG1802 211586007459 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 211586007460 DNA-binding site [nucleotide binding]; DNA binding site 211586007461 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 211586007462 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 211586007463 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 211586007464 dimer interface [polypeptide binding]; other site 211586007465 active site 211586007466 CoA binding pocket [chemical binding]; other site 211586007467 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 211586007468 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 211586007469 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 211586007470 active site 211586007471 catalytic site [active] 211586007472 substrate binding site [chemical binding]; other site 211586007473 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 211586007474 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 211586007475 ligand binding site [chemical binding]; other site 211586007476 flexible hinge region; other site 211586007477 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 211586007478 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 211586007479 metal binding triad; other site 211586007480 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 211586007481 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 211586007482 Na binding site [ion binding]; other site 211586007483 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 211586007484 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 211586007485 catalytic residues [active] 211586007486 hinge region; other site 211586007487 alpha helical domain; other site 211586007488 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 211586007489 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 211586007490 putative NAD(P) binding site [chemical binding]; other site 211586007491 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 211586007492 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211586007493 Zn2+ binding site [ion binding]; other site 211586007494 Mg2+ binding site [ion binding]; other site 211586007495 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 211586007496 Lysine efflux permease [General function prediction only]; Region: COG1279 211586007497 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 211586007498 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586007499 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 211586007500 putative dimerization interface [polypeptide binding]; other site 211586007501 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 211586007502 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 211586007503 CPxP motif; other site 211586007504 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 211586007505 Peptidase family M48; Region: Peptidase_M48; cl12018 211586007506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586007507 binding surface 211586007508 TPR motif; other site 211586007509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586007510 binding surface 211586007511 TPR motif; other site 211586007512 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 211586007513 catalytic residues [active] 211586007514 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 211586007515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 211586007516 Homeodomain-like domain; Region: HTH_23; pfam13384 211586007517 Winged helix-turn helix; Region: HTH_33; pfam13592 211586007518 DDE superfamily endonuclease; Region: DDE_3; pfam13358 211586007519 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 211586007520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586007521 Walker A motif; other site 211586007522 ATP binding site [chemical binding]; other site 211586007523 Walker B motif; other site 211586007524 arginine finger; other site 211586007525 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 211586007526 Sulfate transporter family; Region: Sulfate_transp; cl19250 211586007527 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 211586007528 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 211586007529 putative GSH binding site [chemical binding]; other site 211586007530 catalytic residues [active] 211586007531 superoxide dismutase; Provisional; Region: PRK10543 211586007532 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 211586007533 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 211586007534 PrkA family serine protein kinase; Provisional; Region: PRK15455 211586007535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586007536 Walker A motif; other site 211586007537 ATP binding site [chemical binding]; other site 211586007538 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 211586007539 hypothetical protein; Provisional; Region: PRK05325 211586007540 SpoVR family protein; Provisional; Region: PRK11767 211586007541 fatty acid metabolism regulator; Provisional; Region: PRK04984 211586007542 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 211586007543 DNA-binding site [nucleotide binding]; DNA binding site 211586007544 FadR C-terminal domain; Region: FadR_C; pfam07840 211586007545 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 211586007546 disulfide bond formation protein B; Provisional; Region: PRK01749 211586007547 Cache domain; Region: Cache_1; pfam02743 211586007548 PAS fold; Region: PAS_4; pfam08448 211586007549 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586007550 putative active site [active] 211586007551 heme pocket [chemical binding]; other site 211586007552 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211586007553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586007554 ATP binding site [chemical binding]; other site 211586007555 Mg2+ binding site [ion binding]; other site 211586007556 G-X-G motif; other site 211586007557 SpoIIAA-like; Region: SpoIIAA-like; pfam11964 211586007558 Protein of unknown function (DUF3802); Region: DUF3802; pfam12290 211586007559 YceI-like domain; Region: YceI; pfam04264 211586007560 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 211586007561 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 211586007562 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 211586007563 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 211586007564 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 211586007565 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 211586007566 nucleotide binding pocket [chemical binding]; other site 211586007567 K-X-D-G motif; other site 211586007568 catalytic site [active] 211586007569 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 211586007570 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 211586007571 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 211586007572 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 211586007573 Dimer interface [polypeptide binding]; other site 211586007574 BRCT sequence motif; other site 211586007575 cell division protein ZipA; Provisional; Region: PRK03427 211586007576 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 211586007577 FtsZ protein binding site [polypeptide binding]; other site 211586007578 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 211586007579 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 211586007580 Walker A/P-loop; other site 211586007581 ATP binding site [chemical binding]; other site 211586007582 Q-loop/lid; other site 211586007583 HemX; Region: HemX; cl19375 211586007584 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 211586007585 ABC transporter signature motif; other site 211586007586 Walker B; other site 211586007587 D-loop; other site 211586007588 H-loop/switch region; other site 211586007589 putative sulfate transport protein CysZ; Validated; Region: PRK04949 211586007590 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 211586007591 putative ligand binding site [chemical binding]; other site 211586007592 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 211586007593 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 211586007594 dimer interface [polypeptide binding]; other site 211586007595 active site 211586007596 CoA binding pocket [chemical binding]; other site 211586007597 RDD family; Region: RDD; pfam06271 211586007598 cysteine synthase; Region: PLN02565 211586007599 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 211586007600 dimer interface [polypeptide binding]; other site 211586007601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586007602 catalytic residue [active] 211586007603 O-methyltransferase; Region: Methyltransf_2; pfam00891 211586007604 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 211586007605 gating phenylalanine in ion channel; other site 211586007606 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 211586007607 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 211586007608 N-terminal plug; other site 211586007609 ligand-binding site [chemical binding]; other site 211586007610 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 211586007611 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 211586007612 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 211586007613 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 211586007614 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 211586007615 formate transporter FocA; Region: formate_focA; TIGR04060 211586007616 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 211586007617 Pyruvate formate lyase 1; Region: PFL1; cd01678 211586007618 coenzyme A binding site [chemical binding]; other site 211586007619 active site 211586007620 catalytic residues [active] 211586007621 glycine loop; other site 211586007622 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 211586007623 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211586007624 FeS/SAM binding site; other site 211586007625 Protein of unknown function, DUF412; Region: DUF412; pfam04217 211586007626 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 211586007627 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 211586007628 nucleotide binding site [chemical binding]; other site 211586007629 phosphate acetyltransferase; Reviewed; Region: PRK05632 211586007630 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 211586007631 DRTGG domain; Region: DRTGG; pfam07085 211586007632 phosphate acetyltransferase; Region: pta; TIGR00651 211586007633 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 211586007634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586007635 S-adenosylmethionine binding site [chemical binding]; other site 211586007636 Domain of unknown function DUF20; Region: UPF0118; cl00465 211586007637 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 211586007638 homooctamer interface [polypeptide binding]; other site 211586007639 active site 211586007640 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 211586007641 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 211586007642 putative NAD(P) binding site [chemical binding]; other site 211586007643 putative active site [active] 211586007644 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 211586007645 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 211586007646 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 211586007647 Catalytic site [active] 211586007648 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 211586007649 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 211586007650 FtsX-like permease family; Region: FtsX; pfam02687 211586007651 FtsX-like permease family; Region: FtsX; pfam02687 211586007652 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 211586007653 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 211586007654 Walker A/P-loop; other site 211586007655 ATP binding site [chemical binding]; other site 211586007656 Q-loop/lid; other site 211586007657 ABC transporter signature motif; other site 211586007658 Walker B; other site 211586007659 D-loop; other site 211586007660 H-loop/switch region; other site 211586007661 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 211586007662 active site 211586007663 catalytic triad [active] 211586007664 oxyanion hole [active] 211586007665 switch loop; other site 211586007666 Protein of unknown function (DUF3083); Region: DUF3083; pfam11281 211586007667 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 211586007668 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 211586007669 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 211586007670 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 211586007671 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 211586007672 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 211586007673 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 211586007674 putative inner membrane peptidase; Provisional; Region: PRK11778 211586007675 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 211586007676 tandem repeat interface [polypeptide binding]; other site 211586007677 oligomer interface [polypeptide binding]; other site 211586007678 active site residues [active] 211586007679 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 211586007680 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 211586007681 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 211586007682 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 211586007683 NAD(P) binding site [chemical binding]; other site 211586007684 active site 211586007685 BNR repeat-like domain; Region: BNR_2; pfam13088 211586007686 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 211586007687 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211586007688 RNA binding surface [nucleotide binding]; other site 211586007689 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 211586007690 probable active site [active] 211586007691 prophage LambdaSo 211586007692 Phage-related protein, tail component [Function unknown]; Region: COG4733 211586007693 Putative phage tail protein; Region: Phage-tail_3; pfam13550 211586007694 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 211586007695 Interdomain contacts; other site 211586007696 Cytokine receptor motif; other site 211586007697 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 211586007698 aromatic chitin/cellulose binding site residues [chemical binding]; other site 211586007699 flagellin; Provisional; Region: PRK12802 211586007700 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 211586007701 Phage-related protein, tail component [Function unknown]; Region: COG4723 211586007702 DEAD/H associated; Region: DEAD_assoc; pfam08494 211586007703 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 211586007704 MPN+ (JAMM) motif; other site 211586007705 Zinc-binding site [ion binding]; other site 211586007706 NlpC/P60 family; Region: NLPC_P60; cl17555 211586007707 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 211586007708 Phage-related protein [Function unknown]; Region: gp18; COG4672 211586007709 Sulfocyanin (SoxE); Region: SoxE; cl17563 211586007710 Phage minor tail protein; Region: Phage_min_tail; pfam05939 211586007711 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 211586007712 Phage-related minor tail protein [Function unknown]; Region: COG5281 211586007713 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 211586007714 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901 211586007715 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 211586007716 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 211586007717 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 211586007718 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 211586007719 oligomerization interface [polypeptide binding]; other site 211586007720 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 211586007721 Phage capsid family; Region: Phage_capsid; pfam05065 211586007722 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 211586007723 oligomer interface [polypeptide binding]; other site 211586007724 active site residues [active] 211586007725 Phage portal protein; Region: Phage_portal; pfam04860 211586007726 Phage terminase, small subunit; Region: Terminase_4; pfam05119 211586007727 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 211586007728 Phage Terminase; Region: Terminase_1; cl19862 211586007729 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 211586007730 active site 211586007731 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 211586007732 hypothetical protein; Validated; Region: PRK09039 211586007733 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 211586007734 catalytic residue [active] 211586007735 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 211586007736 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 211586007737 active site 211586007738 Int/Topo IB signature motif; other site 211586007739 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 211586007740 uncharacterized phage protein; Region: phage_xxxx; TIGR02642 211586007741 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 211586007742 Replication protein P; Region: Phage_lambda_P; pfam06992 211586007743 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 211586007744 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211586007745 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 211586007746 non-specific DNA binding site [nucleotide binding]; other site 211586007747 salt bridge; other site 211586007748 sequence-specific DNA binding site [nucleotide binding]; other site 211586007749 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 211586007750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211586007751 non-specific DNA binding site [nucleotide binding]; other site 211586007752 salt bridge; other site 211586007753 sequence-specific DNA binding site [nucleotide binding]; other site 211586007754 Predicted transcriptional regulator [Transcription]; Region: COG2932 211586007755 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 211586007756 Catalytic site [active] 211586007757 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 211586007758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 211586007759 Methyltransferase domain; Region: Methyltransf_26; pfam13659 211586007760 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 211586007761 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 211586007762 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 211586007763 hypothetical protein; Region: PHA00675 211586007764 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 211586007765 cofactor binding site; other site 211586007766 DNA binding site [nucleotide binding] 211586007767 substrate interaction site [chemical binding]; other site 211586007768 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cl19095 211586007769 COG (conserved oligomeric Golgi) complex component, COG2; Region: COG2; cl19297 211586007770 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 211586007771 Helix-turn-helix domain; Region: HTH_17; pfam12728 211586007772 integrase; Provisional; Region: PRK09692 211586007773 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 211586007774 active site 211586007775 Int/Topo IB signature motif; other site 211586007776 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 211586007777 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 211586007778 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 211586007779 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 211586007780 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 211586007781 active site 211586007782 anthranilate synthase component I; Provisional; Region: PRK13564 211586007783 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 211586007784 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 211586007785 Glutamine amidotransferase class-I; Region: GATase; pfam00117 211586007786 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 211586007787 glutamine binding [chemical binding]; other site 211586007788 catalytic triad [active] 211586007789 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 211586007790 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 211586007791 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 211586007792 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 211586007793 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 211586007794 active site 211586007795 ribulose/triose binding site [chemical binding]; other site 211586007796 phosphate binding site [ion binding]; other site 211586007797 substrate (anthranilate) binding pocket [chemical binding]; other site 211586007798 product (indole) binding pocket [chemical binding]; other site 211586007799 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 211586007800 active site 211586007801 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 211586007802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586007803 catalytic residue [active] 211586007804 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 211586007805 substrate binding site [chemical binding]; other site 211586007806 active site 211586007807 catalytic residues [active] 211586007808 heterodimer interface [polypeptide binding]; other site 211586007809 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 211586007810 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 211586007811 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 211586007812 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 211586007813 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 211586007814 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 211586007815 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 211586007816 IucA / IucC family; Region: IucA_IucC; pfam04183 211586007817 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 211586007818 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 211586007819 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 211586007820 N-terminal plug; other site 211586007821 ligand-binding site [chemical binding]; other site 211586007822 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 211586007823 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 211586007824 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 211586007825 intracellular septation protein A; Reviewed; Region: PRK00259 211586007826 YciI-like protein; Reviewed; Region: PRK11370 211586007827 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 211586007828 putative catalytic site [active] 211586007829 putative phosphate binding site [ion binding]; other site 211586007830 active site 211586007831 metal binding site A [ion binding]; metal-binding site 211586007832 DNA binding site [nucleotide binding] 211586007833 putative AP binding site [nucleotide binding]; other site 211586007834 putative metal binding site B [ion binding]; other site 211586007835 Homeodomain-like domain; Region: HTH_23; pfam13384 211586007836 Winged helix-turn helix; Region: HTH_29; pfam13551 211586007837 DDE superfamily endonuclease; Region: DDE_3; pfam13358 211586007838 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 211586007839 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586007840 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586007841 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 211586007842 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 211586007843 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 211586007844 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 211586007845 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 211586007846 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 211586007847 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 211586007848 catalytic loop [active] 211586007849 iron binding site [ion binding]; other site 211586007850 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 211586007851 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 211586007852 Ligand binding site; other site 211586007853 metal-binding site 211586007854 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 211586007855 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 211586007856 XdhC Rossmann domain; Region: XdhC_C; pfam13478 211586007857 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 211586007858 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 211586007859 dimer interface [polypeptide binding]; other site 211586007860 putative CheW interface [polypeptide binding]; other site 211586007861 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 211586007862 Putative lysophospholipase; Region: Hydrolase_4; cl19140 211586007863 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 211586007864 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 211586007865 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 211586007866 active sites [active] 211586007867 tetramer interface [polypeptide binding]; other site 211586007868 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 211586007869 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 211586007870 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 211586007871 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 211586007872 GAF domain; Region: GAF_2; pfam13185 211586007873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586007874 Walker A motif; other site 211586007875 ATP binding site [chemical binding]; other site 211586007876 Walker B motif; other site 211586007877 arginine finger; other site 211586007878 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 211586007879 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 211586007880 trimer interface [polypeptide binding]; other site 211586007881 eyelet of channel; other site 211586007882 DNA topoisomerase III; Provisional; Region: PRK07726 211586007883 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 211586007884 active site 211586007885 putative interdomain interaction site [polypeptide binding]; other site 211586007886 putative metal-binding site [ion binding]; other site 211586007887 putative nucleotide binding site [chemical binding]; other site 211586007888 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 211586007889 domain I; other site 211586007890 DNA binding groove [nucleotide binding] 211586007891 phosphate binding site [ion binding]; other site 211586007892 domain II; other site 211586007893 domain III; other site 211586007894 nucleotide binding site [chemical binding]; other site 211586007895 catalytic site [active] 211586007896 domain IV; other site 211586007897 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 211586007898 amidophosphoribosyltransferase; Provisional; Region: PRK09246 211586007899 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 211586007900 active site 211586007901 tetramer interface [polypeptide binding]; other site 211586007902 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211586007903 active site 211586007904 Colicin V production protein; Region: Colicin_V; cl00567 211586007905 cell division protein DedD; Provisional; Region: PRK11633 211586007906 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 211586007907 Sporulation related domain; Region: SPOR; pfam05036 211586007908 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 211586007909 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 211586007910 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 211586007911 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 211586007912 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 211586007913 dimerization interface 3.5A [polypeptide binding]; other site 211586007914 active site 211586007915 FimV N-terminal domain; Region: FimV_core; TIGR03505 211586007916 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 211586007917 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 211586007918 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 211586007919 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 211586007920 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 211586007921 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 211586007922 ligand binding site [chemical binding]; other site 211586007923 NAD binding site [chemical binding]; other site 211586007924 catalytic site [active] 211586007925 homodimer interface [polypeptide binding]; other site 211586007926 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 211586007927 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 211586007928 dimer interface [polypeptide binding]; other site 211586007929 active site 211586007930 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 211586007931 FAD dependent oxidoreductase; Region: DAO; pfam01266 211586007932 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 211586007933 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 211586007934 YfcL protein; Region: YfcL; pfam08891 211586007935 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 211586007936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586007937 sugar efflux transporter; Region: 2A0120; TIGR00899 211586007938 putative substrate translocation pore; other site 211586007939 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 211586007940 Tetramer interface [polypeptide binding]; other site 211586007941 active site 211586007942 FMN-binding site [chemical binding]; other site 211586007943 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805 211586007944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586007945 S-adenosylmethionine binding site [chemical binding]; other site 211586007946 hypothetical protein; Provisional; Region: PRK04946 211586007947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 211586007948 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 211586007949 catalytic core [active] 211586007950 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 211586007951 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 211586007952 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 211586007953 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 211586007954 Two component regulator propeller; Region: Reg_prop; pfam07494 211586007955 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 211586007956 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 211586007957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586007958 putative active site [active] 211586007959 heme pocket [chemical binding]; other site 211586007960 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586007961 metal binding site [ion binding]; metal-binding site 211586007962 active site 211586007963 I-site; other site 211586007964 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586007965 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 211586007966 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 211586007967 substrate binding site [chemical binding]; other site 211586007968 oxyanion hole (OAH) forming residues; other site 211586007969 trimer interface [polypeptide binding]; other site 211586007970 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 211586007971 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 211586007972 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 211586007973 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 211586007974 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 211586007975 dimer interface [polypeptide binding]; other site 211586007976 active site 211586007977 MoxR-like ATPases [General function prediction only]; Region: COG0714 211586007978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586007979 Walker A motif; other site 211586007980 ATP binding site [chemical binding]; other site 211586007981 Walker B motif; other site 211586007982 arginine finger; other site 211586007983 Protein of unknown function DUF58; Region: DUF58; pfam01882 211586007984 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 211586007985 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 211586007986 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 211586007987 metal ion-dependent adhesion site (MIDAS); other site 211586007988 von Willebrand factor type A domain; Region: VWA_2; pfam13519 211586007989 metal ion-dependent adhesion site (MIDAS); other site 211586007990 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 211586007991 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586007992 TPR motif; other site 211586007993 binding surface 211586007994 Oxygen tolerance; Region: BatD; pfam13584 211586007995 RNA polymerase sigma factor; Provisional; Region: PRK12517 211586007996 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 211586007997 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 211586007998 DNA binding residues [nucleotide binding] 211586007999 Protein of unknown function (DUF3379); Region: DUF3379; pfam11859 211586008000 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 211586008001 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 211586008002 active site 211586008003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 211586008004 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 211586008005 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 211586008006 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 211586008007 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586008008 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 211586008009 MMPL family; Region: MMPL; cl14618 211586008010 MMPL family; Region: MMPL; cl14618 211586008011 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 211586008012 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 211586008013 active site residue [active] 211586008014 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 211586008015 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 211586008016 Subtilase family; Region: Peptidase_S8; pfam00082 211586008017 active site 211586008018 catalytic residues [active] 211586008019 PA_VapT_like: Protease-associated domain containing proteins like VapT from Vibrio metschnikovii strain RH530. This group contains various PA domain-containing proteins similar to V. metschnikovii VapT, including the serine alkaline protease SapSh from...; Region: PA_VapT_like; cd04817 211586008020 PA/subtilisin-like domain interface [polypeptide binding]; other site 211586008021 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 211586008022 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 211586008023 YaeQ protein; Region: YaeQ; pfam07152 211586008024 precorrin-2 dehydrogenase; Validated; Region: PRK06719 211586008025 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 211586008026 Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414 211586008027 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 211586008028 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 211586008029 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 211586008030 Protein export membrane protein; Region: SecD_SecF; pfam02355 211586008031 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 211586008032 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 211586008033 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 211586008034 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 211586008035 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 211586008036 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 211586008037 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 211586008038 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 211586008039 Protein of unknown function, DUF479; Region: DUF479; pfam04336 211586008040 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 211586008041 catalytic residues [active] 211586008042 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 211586008043 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 211586008044 active site 211586008045 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 211586008046 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 211586008047 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 211586008048 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 211586008049 serine/threonine transporter SstT; Provisional; Region: PRK13628 211586008050 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 211586008051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586008052 active site 211586008053 phosphorylation site [posttranslational modification] 211586008054 intermolecular recognition site; other site 211586008055 dimerization interface [polypeptide binding]; other site 211586008056 Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cl00053 211586008057 active site 211586008058 catalytic residues [active] 211586008059 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 211586008060 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 211586008061 ATP binding site [chemical binding]; other site 211586008062 Mg++ binding site [ion binding]; other site 211586008063 motif III; other site 211586008064 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586008065 nucleotide binding region [chemical binding]; other site 211586008066 ATP-binding site [chemical binding]; other site 211586008067 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 211586008068 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 211586008069 DNA binding site [nucleotide binding] 211586008070 active site 211586008071 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 211586008072 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 211586008073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 211586008074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 211586008075 AlkA N-terminal domain; Region: AlkA_N; pfam06029 211586008076 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 211586008077 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 211586008078 minor groove reading motif; other site 211586008079 helix-hairpin-helix signature motif; other site 211586008080 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 211586008081 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211586008082 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211586008083 Walker A/P-loop; other site 211586008084 ATP binding site [chemical binding]; other site 211586008085 Q-loop/lid; other site 211586008086 ABC transporter signature motif; other site 211586008087 Walker B; other site 211586008088 D-loop; other site 211586008089 H-loop/switch region; other site 211586008090 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 211586008091 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 211586008092 active site 211586008093 HIGH motif; other site 211586008094 KMSKS motif; other site 211586008095 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 211586008096 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 211586008097 DctM-like transporters; Region: DctM; pfam06808 211586008098 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 211586008099 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 211586008100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586008101 active site 211586008102 phosphorylation site [posttranslational modification] 211586008103 intermolecular recognition site; other site 211586008104 dimerization interface [polypeptide binding]; other site 211586008105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586008106 Walker A motif; other site 211586008107 ATP binding site [chemical binding]; other site 211586008108 Walker B motif; other site 211586008109 arginine finger; other site 211586008110 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 211586008111 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 211586008112 Transglycosylase; Region: Transgly; cl19357 211586008113 thymidine kinase; Provisional; Region: PRK04296 211586008114 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 211586008115 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 211586008116 active site 211586008117 Zn binding site [ion binding]; other site 211586008118 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 211586008119 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 211586008120 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 211586008121 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 211586008122 Ligand binding site [chemical binding]; other site 211586008123 Domain in histone-like proteins of HNS family; Region: HNS; cl19571 211586008124 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 211586008125 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 211586008126 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 211586008127 active site 211586008128 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 211586008129 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 211586008130 active site 211586008131 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 211586008132 Amidohydrolase; Region: Amidohydro_4; pfam13147 211586008133 active site 211586008134 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 211586008135 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 211586008136 homodimer interaction site [polypeptide binding]; other site 211586008137 cofactor binding site; other site 211586008138 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 211586008139 putative CoA binding site [chemical binding]; other site 211586008140 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 211586008141 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 211586008142 trimer interface [polypeptide binding]; other site 211586008143 active site 211586008144 substrate binding site [chemical binding]; other site 211586008145 CoA binding site [chemical binding]; other site 211586008146 prolyl-tRNA synthetase; Provisional; Region: PRK09194 211586008147 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 211586008148 dimer interface [polypeptide binding]; other site 211586008149 motif 1; other site 211586008150 active site 211586008151 motif 2; other site 211586008152 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 211586008153 putative deacylase active site [active] 211586008154 motif 3; other site 211586008155 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 211586008156 anticodon binding site; other site 211586008157 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 211586008158 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 211586008159 active site 211586008160 nucleophile elbow; other site 211586008161 Group 4 capsule polysaccharide formation lipoprotein gfcB; Region: Cap_synth_GfcB; pfam11102 211586008162 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 211586008163 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 211586008164 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 211586008165 GAF domain; Region: GAF; pfam01590 211586008166 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211586008167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586008168 ATP binding site [chemical binding]; other site 211586008169 Mg2+ binding site [ion binding]; other site 211586008170 G-X-G motif; other site 211586008171 NlpE N-terminal domain; Region: NlpE; pfam04170 211586008172 HutD; Region: HutD; pfam05962 211586008173 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 211586008174 active site 211586008175 NTP binding site [chemical binding]; other site 211586008176 metal binding triad [ion binding]; metal-binding site 211586008177 antibiotic binding site [chemical binding]; other site 211586008178 Protein of unknown function DUF86; Region: DUF86; pfam01934 211586008179 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 211586008180 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 211586008181 NAD binding site [chemical binding]; other site 211586008182 substrate binding site [chemical binding]; other site 211586008183 homodimer interface [polypeptide binding]; other site 211586008184 active site 211586008185 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 211586008186 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211586008187 non-specific DNA binding site [nucleotide binding]; other site 211586008188 salt bridge; other site 211586008189 sequence-specific DNA binding site [nucleotide binding]; other site 211586008190 HipA N-terminal domain; Region: Couple_hipA; cl11853 211586008191 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 211586008192 HipA-like N-terminal domain; Region: HipA_N; pfam07805 211586008193 HipA-like C-terminal domain; Region: HipA_C; pfam07804 211586008194 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 211586008195 CoA binding domain; Region: CoA_binding; cl17356 211586008196 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 211586008197 NAD(P) binding site [chemical binding]; other site 211586008198 homodimer interface [polypeptide binding]; other site 211586008199 substrate binding site [chemical binding]; other site 211586008200 active site 211586008201 Bacterial sugar transferase; Region: Bac_transf; pfam02397 211586008202 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 211586008203 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 211586008204 putative NAD(P) binding site [chemical binding]; other site 211586008205 active site 211586008206 putative substrate binding site [chemical binding]; other site 211586008207 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 211586008208 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 211586008209 putative ADP-binding pocket [chemical binding]; other site 211586008210 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 211586008211 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 211586008212 active site 211586008213 dimer interface [polypeptide binding]; other site 211586008214 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 211586008215 Ligand Binding Site [chemical binding]; other site 211586008216 Molecular Tunnel; other site 211586008217 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 211586008218 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 211586008219 putative ADP-binding pocket [chemical binding]; other site 211586008220 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 211586008221 putative active site [active] 211586008222 putative cosubstrate binding site; other site 211586008223 putative substrate binding site [chemical binding]; other site 211586008224 catalytic site [active] 211586008225 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u5; cd10929 211586008226 putative active site [active] 211586008227 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 211586008228 trimer interface [polypeptide binding]; other site 211586008229 active site 211586008230 substrate binding site [chemical binding]; other site 211586008231 CoA binding site [chemical binding]; other site 211586008232 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 211586008233 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 211586008234 active site 211586008235 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 211586008236 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 211586008237 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586008238 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 211586008239 Coenzyme A binding pocket [chemical binding]; other site 211586008240 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 211586008241 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 211586008242 catalytic residue [active] 211586008243 WbqC-like protein family; Region: WbqC; pfam08889 211586008244 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 211586008245 inhibitor-cofactor binding pocket; inhibition site 211586008246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586008247 catalytic residue [active] 211586008248 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 211586008249 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 211586008250 substrate binding site; other site 211586008251 tetramer interface; other site 211586008252 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 211586008253 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 211586008254 NAD binding site [chemical binding]; other site 211586008255 substrate binding site [chemical binding]; other site 211586008256 homodimer interface [polypeptide binding]; other site 211586008257 active site 211586008258 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 211586008259 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 211586008260 NAD binding site [chemical binding]; other site 211586008261 substrate binding site [chemical binding]; other site 211586008262 homodimer interface [polypeptide binding]; other site 211586008263 active site 211586008264 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 211586008265 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 211586008266 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 211586008267 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 211586008268 LPS O-antigen length regulator; Provisional; Region: PRK10381 211586008269 Chain length determinant protein; Region: Wzz; pfam02706 211586008270 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 211586008271 hypothetical protein; Reviewed; Region: PRK12275 211586008272 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 211586008273 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 211586008274 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 211586008275 SLBB domain; Region: SLBB; pfam10531 211586008276 SLBB domain; Region: SLBB; pfam10531 211586008277 SLBB domain; Region: SLBB; pfam10531 211586008278 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 211586008279 SLBB domain; Region: SLBB; pfam10531 211586008280 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 211586008281 transcriptional activator RfaH; Region: RfaH; TIGR01955 211586008282 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 211586008283 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 211586008284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586008285 putative substrate translocation pore; other site 211586008286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586008287 active site 211586008288 phosphorylation site [posttranslational modification] 211586008289 intermolecular recognition site; other site 211586008290 dimerization interface [polypeptide binding]; other site 211586008291 VacJ like lipoprotein; Region: VacJ; cl01073 211586008292 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 211586008293 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 211586008294 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 211586008295 putative CheA interaction surface; other site 211586008296 CheW-like domain; Region: CheW; pfam01584 211586008297 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 211586008298 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 211586008299 P-loop; other site 211586008300 Magnesium ion binding site [ion binding]; other site 211586008301 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 211586008302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586008303 active site 211586008304 phosphorylation site [posttranslational modification] 211586008305 intermolecular recognition site; other site 211586008306 dimerization interface [polypeptide binding]; other site 211586008307 CheB methylesterase; Region: CheB_methylest; pfam01339 211586008308 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 211586008309 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 211586008310 putative binding surface; other site 211586008311 active site 211586008312 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 211586008313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586008314 ATP binding site [chemical binding]; other site 211586008315 Mg2+ binding site [ion binding]; other site 211586008316 G-X-G motif; other site 211586008317 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 211586008318 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 211586008319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586008320 active site 211586008321 phosphorylation site [posttranslational modification] 211586008322 intermolecular recognition site; other site 211586008323 dimerization interface [polypeptide binding]; other site 211586008324 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 211586008325 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 211586008326 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 211586008327 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 211586008328 DNA binding residues [nucleotide binding] 211586008329 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 211586008330 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 211586008331 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 211586008332 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 211586008333 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 211586008334 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 211586008335 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 211586008336 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 211586008337 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 211586008338 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 211586008339 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 211586008340 flagellar motor switch protein; Validated; Region: fliN; PRK08983 211586008341 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 211586008342 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 211586008343 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696 211586008344 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 211586008345 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 211586008346 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08972 211586008347 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 211586008348 Walker A motif/ATP binding site; other site 211586008349 Walker B motif; other site 211586008350 flagellar assembly protein H; Validated; Region: fliH; PRK05687 211586008351 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 211586008352 Flagellar assembly protein FliH; Region: FliH; pfam02108 211586008353 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 211586008354 FliG N-terminal domain; Region: FliG_N; pfam14842 211586008355 FliG middle domain; Region: FliG_M; pfam14841 211586008356 FliG C-terminal domain; Region: FliG_C; pfam01706 211586008357 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 211586008358 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 211586008359 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 211586008360 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 211586008361 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 211586008362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586008363 active site 211586008364 phosphorylation site [posttranslational modification] 211586008365 intermolecular recognition site; other site 211586008366 dimerization interface [polypeptide binding]; other site 211586008367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586008368 Walker A motif; other site 211586008369 ATP binding site [chemical binding]; other site 211586008370 Walker B motif; other site 211586008371 arginine finger; other site 211586008372 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 211586008373 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 211586008374 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586008375 putative active site [active] 211586008376 heme pocket [chemical binding]; other site 211586008377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586008378 ATP binding site [chemical binding]; other site 211586008379 Mg2+ binding site [ion binding]; other site 211586008380 G-X-G motif; other site 211586008381 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 211586008382 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 211586008383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586008384 Walker A motif; other site 211586008385 ATP binding site [chemical binding]; other site 211586008386 Walker B motif; other site 211586008387 arginine finger; other site 211586008388 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 211586008389 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 211586008390 flagellar protein FliS; Validated; Region: fliS; PRK05685 211586008391 flagellar capping protein; Reviewed; Region: fliD; PRK08032 211586008392 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 211586008393 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 211586008394 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 211586008395 FlaG protein; Region: FlaG; pfam03646 211586008396 flagellin; Reviewed; Region: PRK08869 211586008397 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 211586008398 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 211586008399 flagellin; Reviewed; Region: PRK08869 211586008400 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 211586008401 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 211586008402 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 211586008403 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 211586008404 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08871 211586008405 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 211586008406 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 211586008407 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 211586008408 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 211586008409 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 211586008410 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 211586008411 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 211586008412 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 211586008413 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 211586008414 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 211586008415 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 211586008416 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 211586008417 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 211586008418 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 211586008419 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 211586008420 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 211586008421 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 211586008422 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 211586008423 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 211586008424 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 211586008425 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 211586008426 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 211586008427 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12631 211586008428 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 211586008429 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 211586008430 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12625 211586008431 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 211586008432 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 211586008433 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 211586008434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586008435 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 211586008436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586008437 active site 211586008438 phosphorylation site [posttranslational modification] 211586008439 intermolecular recognition site; other site 211586008440 dimerization interface [polypeptide binding]; other site 211586008441 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 211586008442 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 211586008443 FlgN protein; Region: FlgN; pfam05130 211586008444 LPP20 lipoprotein; Region: LPP20; pfam02169 211586008445 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 211586008446 NeuB family; Region: NeuB; pfam03102 211586008447 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 211586008448 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 211586008449 PYR/PP interface [polypeptide binding]; other site 211586008450 dimer interface [polypeptide binding]; other site 211586008451 TPP binding site [chemical binding]; other site 211586008452 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 211586008453 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 211586008454 TPP-binding site [chemical binding]; other site 211586008455 dimer interface [polypeptide binding]; other site 211586008456 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 211586008457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 211586008458 NAD(P) binding site [chemical binding]; other site 211586008459 active site 211586008460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586008461 S-adenosylmethionine binding site [chemical binding]; other site 211586008462 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 211586008463 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 211586008464 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 211586008465 active site 211586008466 Methyltransferase domain; Region: Methyltransf_31; pfam13847 211586008467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586008468 S-adenosylmethionine binding site [chemical binding]; other site 211586008469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586008470 S-adenosylmethionine binding site [chemical binding]; other site 211586008471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 211586008472 N-terminal catalytic domain of alpha-galactosidase; glycoside hydrolase family 57 (GH57); Region: GH57N_PfGalA_like; cd10794 211586008473 putative active site [active] 211586008474 catalytic site [active] 211586008475 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 211586008476 ligand binding site; other site 211586008477 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 211586008478 inhibitor-cofactor binding pocket; inhibition site 211586008479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586008480 catalytic residue [active] 211586008481 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 211586008482 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 211586008483 NAD(P) binding site [chemical binding]; other site 211586008484 homodimer interface [polypeptide binding]; other site 211586008485 substrate binding site [chemical binding]; other site 211586008486 active site 211586008487 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 211586008488 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 211586008489 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586008490 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 211586008491 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 211586008492 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 211586008493 Protein of unknown function (DUF2947); Region: DUF2947; pfam11163 211586008494 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 211586008495 Autotransporter beta-domain; Region: Autotransporter; smart00869 211586008496 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 211586008497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211586008498 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 211586008499 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 211586008500 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586008501 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 211586008502 MMPL family; Region: MMPL; cl14618 211586008503 Protein of unknown function (DUF465); Region: DUF465; pfam04325 211586008504 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586008505 dimerization interface [polypeptide binding]; other site 211586008506 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 211586008507 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 211586008508 dimer interface [polypeptide binding]; other site 211586008509 putative CheW interface [polypeptide binding]; other site 211586008510 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 211586008511 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 211586008512 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 211586008513 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 211586008514 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 211586008515 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 211586008516 dimerization interface [polypeptide binding]; other site 211586008517 ATP binding site [chemical binding]; other site 211586008518 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 211586008519 dimerization interface [polypeptide binding]; other site 211586008520 ATP binding site [chemical binding]; other site 211586008521 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 211586008522 putative active site [active] 211586008523 catalytic triad [active] 211586008524 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 211586008525 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211586008526 substrate binding pocket [chemical binding]; other site 211586008527 membrane-bound complex binding site; other site 211586008528 hinge residues; other site 211586008529 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 211586008530 N-acetyl-D-glucosamine binding site [chemical binding]; other site 211586008531 catalytic residue [active] 211586008532 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 211586008533 nucleoside/Zn binding site; other site 211586008534 dimer interface [polypeptide binding]; other site 211586008535 catalytic motif [active] 211586008536 GMP synthase; Reviewed; Region: guaA; PRK00074 211586008537 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 211586008538 AMP/PPi binding site [chemical binding]; other site 211586008539 candidate oxyanion hole; other site 211586008540 catalytic triad [active] 211586008541 potential glutamine specificity residues [chemical binding]; other site 211586008542 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 211586008543 ATP Binding subdomain [chemical binding]; other site 211586008544 Ligand Binding sites [chemical binding]; other site 211586008545 Dimerization subdomain; other site 211586008546 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 211586008547 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 211586008548 active site 211586008549 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 211586008550 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 211586008551 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 211586008552 generic binding surface II; other site 211586008553 generic binding surface I; other site 211586008554 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 211586008555 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586008556 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586008557 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586008558 Phosphate-selective porin O and P; Region: Porin_O_P; cl19535 211586008559 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 211586008560 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 211586008561 active sites [active] 211586008562 tetramer interface [polypeptide binding]; other site 211586008563 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 211586008564 L-aspartate oxidase; Provisional; Region: PRK06175 211586008565 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 211586008566 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 211586008567 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 211586008568 Subtilase family; Region: Peptidase_S8; pfam00082 211586008569 active site 211586008570 catalytic triad [active] 211586008571 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 211586008572 PA/protease or protease-like domain interface [polypeptide binding]; other site 211586008573 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 211586008574 GlyGly-CTERM domain; Region: GlyGly_CTERM; TIGR03501 211586008575 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 211586008576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586008577 active site 211586008578 phosphorylation site [posttranslational modification] 211586008579 intermolecular recognition site; other site 211586008580 dimerization interface [polypeptide binding]; other site 211586008581 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 211586008582 DNA binding residues [nucleotide binding] 211586008583 dimerization interface [polypeptide binding]; other site 211586008584 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 211586008585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211586008586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586008587 dimer interface [polypeptide binding]; other site 211586008588 phosphorylation site [posttranslational modification] 211586008589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586008590 ATP binding site [chemical binding]; other site 211586008591 Mg2+ binding site [ion binding]; other site 211586008592 G-X-G motif; other site 211586008593 GTP-binding protein Der; Reviewed; Region: PRK00093 211586008594 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 211586008595 G1 box; other site 211586008596 GTP/Mg2+ binding site [chemical binding]; other site 211586008597 Switch I region; other site 211586008598 G2 box; other site 211586008599 Switch II region; other site 211586008600 G3 box; other site 211586008601 G4 box; other site 211586008602 G5 box; other site 211586008603 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 211586008604 G1 box; other site 211586008605 GTP/Mg2+ binding site [chemical binding]; other site 211586008606 Switch I region; other site 211586008607 G2 box; other site 211586008608 G3 box; other site 211586008609 Switch II region; other site 211586008610 G4 box; other site 211586008611 G5 box; other site 211586008612 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 211586008613 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 211586008614 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 211586008615 Trp docking motif [polypeptide binding]; other site 211586008616 active site 211586008617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 211586008618 Tetratricopeptide repeat; Region: TPR_21; pfam09976 211586008619 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 211586008620 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 211586008621 dimer interface [polypeptide binding]; other site 211586008622 motif 1; other site 211586008623 active site 211586008624 motif 2; other site 211586008625 motif 3; other site 211586008626 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 211586008627 anticodon binding site; other site 211586008628 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 211586008629 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 211586008630 cytoskeletal protein RodZ; Provisional; Region: PRK10856 211586008631 Helix-turn-helix domain; Region: HTH_25; pfam13413 211586008632 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 211586008633 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 211586008634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586008635 binding surface 211586008636 TPR motif; other site 211586008637 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586008638 binding surface 211586008639 TPR motif; other site 211586008640 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 211586008641 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211586008642 FeS/SAM binding site; other site 211586008643 Domain of unknown function DUF21; Region: DUF21; pfam01595 211586008644 FOG: CBS domain [General function prediction only]; Region: COG0517 211586008645 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 211586008646 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 211586008647 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 211586008648 active site 211586008649 metal binding site [ion binding]; metal-binding site 211586008650 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 211586008651 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586008652 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 211586008653 The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which regulates expression of the heme uptake receptor HupA; contains the type 2 periplasmic binding fold; Region: PBP2_HupR; cd08431 211586008654 putative dimerization interface [polypeptide binding]; other site 211586008655 Predicted membrane protein [Function unknown]; Region: COG2259 211586008656 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 211586008657 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 211586008658 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 211586008659 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586008660 Coenzyme A binding pocket [chemical binding]; other site 211586008661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586008662 Coenzyme A binding pocket [chemical binding]; other site 211586008663 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 211586008664 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586008665 Coenzyme A binding pocket [chemical binding]; other site 211586008666 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 211586008667 ParA-like protein; Provisional; Region: PHA02518 211586008668 Magnesium ion binding site [ion binding]; other site 211586008669 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 211586008670 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 211586008671 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586008672 metal binding site [ion binding]; metal-binding site 211586008673 active site 211586008674 I-site; other site 211586008675 Glucose-regulated metallo-peptidase M90; Region: Peptidase_M90; pfam06167 211586008676 SnoaL-like domain; Region: SnoaL_3; pfam13474 211586008677 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 211586008678 GAF domain; Region: GAF_3; pfam13492 211586008679 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 211586008680 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 211586008681 tetramer interface [polypeptide binding]; other site 211586008682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586008683 catalytic residue [active] 211586008684 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 211586008685 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 211586008686 ligand binding site [chemical binding]; other site 211586008687 Conserved TM helix; Region: TM_helix; pfam05552 211586008688 mechanosensitive channel MscS; Provisional; Region: PRK10334 211586008689 Mechanosensitive ion channel; Region: MS_channel; pfam00924 211586008690 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 211586008691 dimer interface [polypeptide binding]; other site 211586008692 catalytic triad [active] 211586008693 peroxidatic and resolving cysteines [active] 211586008694 Predicted membrane protein [Function unknown]; Region: COG2860 211586008695 UPF0126 domain; Region: UPF0126; pfam03458 211586008696 UPF0126 domain; Region: UPF0126; pfam03458 211586008697 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 211586008698 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 211586008699 putative rRNA binding site [nucleotide binding]; other site 211586008700 hypothetical protein; Validated; Region: PRK00228 211586008701 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 211586008702 ferrochelatase; Reviewed; Region: hemH; PRK00035 211586008703 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 211586008704 C-terminal domain interface [polypeptide binding]; other site 211586008705 active site 211586008706 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 211586008707 active site 211586008708 N-terminal domain interface [polypeptide binding]; other site 211586008709 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 211586008710 catalytic residues [active] 211586008711 dimer interface [polypeptide binding]; other site 211586008712 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 211586008713 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 211586008714 Walker A motif; other site 211586008715 ATP binding site [chemical binding]; other site 211586008716 Walker B motif; other site 211586008717 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 211586008718 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 211586008719 Walker A motif; other site 211586008720 ATP binding site [chemical binding]; other site 211586008721 Walker B motif; other site 211586008722 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 211586008723 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 211586008724 catalytic residue [active] 211586008725 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 211586008726 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 211586008727 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 211586008728 YGGT family; Region: YGGT; pfam02325 211586008729 YGGT family; Region: YGGT; pfam02325 211586008730 hypothetical protein; Validated; Region: PRK05090 211586008731 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 211586008732 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 211586008733 active site 211586008734 dimerization interface [polypeptide binding]; other site 211586008735 HemN family oxidoreductase; Provisional; Region: PRK05660 211586008736 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211586008737 FeS/SAM binding site; other site 211586008738 HemN C-terminal domain; Region: HemN_C; pfam06969 211586008739 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586008740 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586008741 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 211586008742 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586008743 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586008744 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 211586008745 putative effector binding pocket; other site 211586008746 dimerization interface [polypeptide binding]; other site 211586008747 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 211586008748 glutaminase; Provisional; Region: PRK00971 211586008749 hypothetical protein; Provisional; Region: PRK11702 211586008750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586008751 S-adenosylmethionine binding site [chemical binding]; other site 211586008752 adenine DNA glycosylase; Provisional; Region: PRK10880 211586008753 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 211586008754 minor groove reading motif; other site 211586008755 helix-hairpin-helix signature motif; other site 211586008756 substrate binding pocket [chemical binding]; other site 211586008757 active site 211586008758 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 211586008759 DNA binding and oxoG recognition site [nucleotide binding] 211586008760 oxidative damage protection protein; Provisional; Region: PRK05408 211586008761 hypothetical protein; Provisional; Region: PRK03757 211586008762 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 211586008763 Protein of unknown function (DUF3634); Region: DUF3634; pfam12321 211586008764 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 211586008765 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 211586008766 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 211586008767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586008768 S-adenosylmethionine binding site [chemical binding]; other site 211586008769 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 211586008770 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 211586008771 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 211586008772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 211586008773 short chain dehydrogenase; Provisional; Region: PRK07024 211586008774 NAD(P) binding site [chemical binding]; other site 211586008775 active site 211586008776 SnoaL-like domain; Region: SnoaL_2; pfam12680 211586008777 DNA photolyase; Region: DNA_photolyase; pfam00875 211586008778 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 211586008779 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 211586008780 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 211586008781 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 211586008782 DNA binding residues [nucleotide binding] 211586008783 Protein of unknown function (DUF523); Region: DUF523; pfam04463 211586008784 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 211586008785 High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I...; Region: HMG-box; cl00082 211586008786 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 211586008787 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 211586008788 ATP binding site [chemical binding]; other site 211586008789 Mg++ binding site [ion binding]; other site 211586008790 motif III; other site 211586008791 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586008792 nucleotide binding region [chemical binding]; other site 211586008793 ATP-binding site [chemical binding]; other site 211586008794 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 211586008795 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586008796 putative active site [active] 211586008797 heme pocket [chemical binding]; other site 211586008798 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586008799 metal binding site [ion binding]; metal-binding site 211586008800 active site 211586008801 I-site; other site 211586008802 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586008803 AAA domain; Region: AAA_32; pfam13654 211586008804 ATP-dependent protease Lon; Provisional; Region: PRK13765 211586008805 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 211586008806 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 211586008807 FMN binding site [chemical binding]; other site 211586008808 active site 211586008809 substrate binding site [chemical binding]; other site 211586008810 catalytic residue [active] 211586008811 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 211586008812 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211586008813 Protein of unknown function (DUF2375); Region: DUF2375; pfam09558 211586008814 Transposase; Region: HTH_Tnp_1; pfam01527 211586008815 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586008816 putative transposase OrfB; Reviewed; Region: PHA02517 211586008817 HTH-like domain; Region: HTH_21; pfam13276 211586008818 Integrase core domain; Region: rve; pfam00665 211586008819 Integrase core domain; Region: rve_2; pfam13333 211586008820 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586008821 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586008822 hypothetical protein; Provisional; Region: PRK12378 211586008823 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 211586008824 30S subunit binding site; other site 211586008825 PAS domain; Region: PAS_9; pfam13426 211586008826 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586008827 putative active site [active] 211586008828 heme pocket [chemical binding]; other site 211586008829 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 211586008830 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 211586008831 dimer interface [polypeptide binding]; other site 211586008832 putative CheW interface [polypeptide binding]; other site 211586008833 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 211586008834 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 211586008835 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 211586008836 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 211586008837 OsmC-like protein; Region: OsmC; cl00767 211586008838 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 211586008839 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 211586008840 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 211586008841 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 211586008842 Domain interface; other site 211586008843 C-terminal peptidase (prc); Region: prc; TIGR00225 211586008844 Active site tetrad [active] 211586008845 Peptide binding site; other site 211586008846 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 211586008847 protein binding site [polypeptide binding]; other site 211586008848 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211586008849 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211586008850 substrate binding pocket [chemical binding]; other site 211586008851 membrane-bound complex binding site; other site 211586008852 hinge residues; other site 211586008853 threonine synthase; Validated; Region: PRK09225 211586008854 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 211586008855 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 211586008856 catalytic residue [active] 211586008857 homoserine kinase; Provisional; Region: PRK01212 211586008858 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 211586008859 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 211586008860 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 211586008861 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 211586008862 putative catalytic residues [active] 211586008863 putative nucleotide binding site [chemical binding]; other site 211586008864 putative aspartate binding site [chemical binding]; other site 211586008865 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 211586008866 dimer interface [polypeptide binding]; other site 211586008867 putative threonine allosteric regulatory site; other site 211586008868 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 211586008869 putative threonine allosteric regulatory site; other site 211586008870 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 211586008871 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 211586008872 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl19519 211586008873 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 211586008874 Trp repressor protein; Region: Trp_repressor; pfam01371 211586008875 Cytochrome C' Region: Cytochrom_C_2; pfam01322 211586008876 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 211586008877 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 211586008878 30S subunit binding site; other site 211586008879 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 211586008880 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 211586008881 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 211586008882 active site 211586008883 HIGH motif; other site 211586008884 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 211586008885 KMSKS motif; other site 211586008886 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 211586008887 tRNA binding surface [nucleotide binding]; other site 211586008888 anticodon binding site; other site 211586008889 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 211586008890 carbon storage regulator; Provisional; Region: PRK01712 211586008891 aspartate kinase; Reviewed; Region: PRK06635 211586008892 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 211586008893 putative nucleotide binding site [chemical binding]; other site 211586008894 putative catalytic residues [active] 211586008895 putative Mg ion binding site [ion binding]; other site 211586008896 putative aspartate binding site [chemical binding]; other site 211586008897 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 211586008898 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 211586008899 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 211586008900 motif 1; other site 211586008901 active site 211586008902 motif 2; other site 211586008903 motif 3; other site 211586008904 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 211586008905 DHHA1 domain; Region: DHHA1; pfam02272 211586008906 RecX family; Region: RecX; pfam02631 211586008907 recombinase A; Provisional; Region: recA; PRK09354 211586008908 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 211586008909 hexamer interface [polypeptide binding]; other site 211586008910 Walker A motif; other site 211586008911 ATP binding site [chemical binding]; other site 211586008912 Walker B motif; other site 211586008913 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 211586008914 MutS domain I; Region: MutS_I; pfam01624 211586008915 MutS domain II; Region: MutS_II; pfam05188 211586008916 MutS domain III; Region: MutS_III; pfam05192 211586008917 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 211586008918 Walker A/P-loop; other site 211586008919 ATP binding site [chemical binding]; other site 211586008920 Q-loop/lid; other site 211586008921 ABC transporter signature motif; other site 211586008922 Walker B; other site 211586008923 D-loop; other site 211586008924 H-loop/switch region; other site 211586008925 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 211586008926 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 211586008927 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 211586008928 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 211586008929 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 211586008930 DNA binding residues [nucleotide binding] 211586008931 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 211586008932 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 211586008933 Peptidase family M23; Region: Peptidase_M23; pfam01551 211586008934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586008935 S-adenosylmethionine binding site [chemical binding]; other site 211586008936 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 211586008937 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 211586008938 Permutation of conserved domain; other site 211586008939 active site 211586008940 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 211586008941 homotrimer interaction site [polypeptide binding]; other site 211586008942 zinc binding site [ion binding]; other site 211586008943 CDP-binding sites; other site 211586008944 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 211586008945 substrate binding site; other site 211586008946 dimer interface; other site 211586008947 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 211586008948 enolase; Provisional; Region: eno; PRK00077 211586008949 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 211586008950 dimer interface [polypeptide binding]; other site 211586008951 metal binding site [ion binding]; metal-binding site 211586008952 substrate binding pocket [chemical binding]; other site 211586008953 CTP synthetase; Validated; Region: pyrG; PRK05380 211586008954 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 211586008955 Catalytic site [active] 211586008956 active site 211586008957 UTP binding site [chemical binding]; other site 211586008958 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 211586008959 active site 211586008960 putative oxyanion hole; other site 211586008961 catalytic triad [active] 211586008962 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 211586008963 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 211586008964 homodimer interface [polypeptide binding]; other site 211586008965 metal binding site [ion binding]; metal-binding site 211586008966 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 211586008967 homodimer interface [polypeptide binding]; other site 211586008968 active site 211586008969 putative chemical substrate binding site [chemical binding]; other site 211586008970 metal binding site [ion binding]; metal-binding site 211586008971 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586008972 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586008973 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 211586008974 Transposase IS200 like; Region: Transposase_17; cl00848 211586008975 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 211586008976 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586008977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586008978 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 211586008979 HD domain; Region: HD_4; pfam13328 211586008980 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 211586008981 synthetase active site [active] 211586008982 NTP binding site [chemical binding]; other site 211586008983 metal binding site [ion binding]; metal-binding site 211586008984 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 211586008985 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 211586008986 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 211586008987 TRAM domain; Region: TRAM; pfam01938 211586008988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586008989 S-adenosylmethionine binding site [chemical binding]; other site 211586008990 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 211586008991 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 211586008992 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586008993 dimerization interface [polypeptide binding]; other site 211586008994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586008995 dimer interface [polypeptide binding]; other site 211586008996 phosphorylation site [posttranslational modification] 211586008997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586008998 ATP binding site [chemical binding]; other site 211586008999 Mg2+ binding site [ion binding]; other site 211586009000 G-X-G motif; other site 211586009001 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 211586009002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586009003 active site 211586009004 phosphorylation site [posttranslational modification] 211586009005 intermolecular recognition site; other site 211586009006 dimerization interface [polypeptide binding]; other site 211586009007 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 211586009008 putative binding surface; other site 211586009009 active site 211586009010 Protein of unknown function (DUF416); Region: DUF416; pfam04222 211586009011 Protein of unknown function (DUF3319); Region: DUF3319; pfam11782 211586009012 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586009013 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586009014 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 211586009015 dimerization interface [polypeptide binding]; other site 211586009016 putative effector binding pocket; other site 211586009017 Predicted permeases [General function prediction only]; Region: COG0679 211586009018 recombination and repair protein; Provisional; Region: PRK10869 211586009019 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 211586009020 Walker A/P-loop; other site 211586009021 ATP binding site [chemical binding]; other site 211586009022 Q-loop/lid; other site 211586009023 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 211586009024 ABC transporter signature motif; other site 211586009025 Walker B; other site 211586009026 D-loop; other site 211586009027 H-loop/switch region; other site 211586009028 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 211586009029 tetramer interfaces [polypeptide binding]; other site 211586009030 binuclear metal-binding site [ion binding]; other site 211586009031 thiamine monophosphate kinase; Provisional; Region: PRK05731 211586009032 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 211586009033 ATP binding site [chemical binding]; other site 211586009034 dimerization interface [polypeptide binding]; other site 211586009035 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 211586009036 putative RNA binding site [nucleotide binding]; other site 211586009037 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 211586009038 homopentamer interface [polypeptide binding]; other site 211586009039 active site 211586009040 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 211586009041 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 211586009042 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 211586009043 dimerization interface [polypeptide binding]; other site 211586009044 active site 211586009045 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 211586009046 Lumazine binding domain; Region: Lum_binding; pfam00677 211586009047 Lumazine binding domain; Region: Lum_binding; pfam00677 211586009048 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 211586009049 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 211586009050 catalytic motif [active] 211586009051 Zn binding site [ion binding]; other site 211586009052 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 211586009053 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 211586009054 ATP cone domain; Region: ATP-cone; pfam03477 211586009055 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 211586009056 dimer interface [polypeptide binding]; other site 211586009057 active site 211586009058 glycine-pyridoxal phosphate binding site [chemical binding]; other site 211586009059 folate binding site [chemical binding]; other site 211586009060 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 211586009061 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 211586009062 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 211586009063 ABC transporter; Region: ABC_tran_2; pfam12848 211586009064 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 211586009065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586009066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586009067 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 211586009068 putative effector binding pocket; other site 211586009069 dimerization interface [polypeptide binding]; other site 211586009070 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 211586009071 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 211586009072 catalytic residues [active] 211586009073 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 211586009074 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 211586009075 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586009076 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 211586009077 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 211586009078 Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425 211586009079 active site 211586009080 metal binding site [ion binding]; metal-binding site 211586009081 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211586009082 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211586009083 substrate binding pocket [chemical binding]; other site 211586009084 membrane-bound complex binding site; other site 211586009085 hinge residues; other site 211586009086 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 211586009087 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 211586009088 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586009089 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 211586009090 MMPL family; Region: MMPL; cl14618 211586009091 MMPL family; Region: MMPL; cl14618 211586009092 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 211586009093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586009094 putative substrate translocation pore; other site 211586009095 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 211586009096 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 211586009097 Helix-turn-helix domain; Region: HTH_18; pfam12833 211586009098 PAS fold; Region: PAS_3; pfam08447 211586009099 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586009100 metal binding site [ion binding]; metal-binding site 211586009101 active site 211586009102 I-site; other site 211586009103 Uncharacterized conserved protein [Function unknown]; Region: COG1432 211586009104 LabA_like proteins; Region: LabA; cd10911 211586009105 putative metal binding site [ion binding]; other site 211586009106 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211586009107 Zn2+ binding site [ion binding]; other site 211586009108 Mg2+ binding site [ion binding]; other site 211586009109 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 211586009110 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211586009111 Zn2+ binding site [ion binding]; other site 211586009112 Mg2+ binding site [ion binding]; other site 211586009113 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 211586009114 MMPL family; Region: MMPL; cl14618 211586009115 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 211586009116 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 211586009117 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586009118 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 211586009119 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211586009120 OsmC-like protein; Region: OsmC; pfam02566 211586009121 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 211586009122 NAD(P) binding site [chemical binding]; other site 211586009123 catalytic residues [active] 211586009124 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 211586009125 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 211586009126 inhibitor-cofactor binding pocket; inhibition site 211586009127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586009128 catalytic residue [active] 211586009129 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586009130 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 211586009131 conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001 211586009132 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 211586009133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586009134 putative substrate translocation pore; other site 211586009135 L-fucose transporter; Provisional; Region: PRK10133; cl17665 211586009136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 211586009137 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 211586009138 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 211586009139 active site 211586009140 dimer interface [polypeptide binding]; other site 211586009141 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 211586009142 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 211586009143 dimer interface [polypeptide binding]; other site 211586009144 active site 211586009145 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 211586009146 dimer interface [polypeptide binding]; other site 211586009147 active site 211586009148 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 211586009149 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 211586009150 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 211586009151 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 211586009152 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; cl03741 211586009153 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 211586009154 active site 211586009155 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 211586009156 SapC; Region: SapC; pfam07277 211586009157 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 211586009158 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 211586009159 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 211586009160 N-terminal plug; other site 211586009161 ligand-binding site [chemical binding]; other site 211586009162 Transcriptional regulators [Transcription]; Region: PurR; COG1609 211586009163 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 211586009164 DNA binding site [nucleotide binding] 211586009165 domain linker motif; other site 211586009166 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 211586009167 putative ligand binding site [chemical binding]; other site 211586009168 putative dimerization interface [polypeptide binding]; other site 211586009169 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 211586009170 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 211586009171 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586009172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586009173 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 211586009174 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 211586009175 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 211586009176 Type II transport protein GspH; Region: GspH; pfam12019 211586009177 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 211586009178 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 211586009179 Type II transport protein GspH; Region: GspH; pfam12019 211586009180 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586009181 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586009182 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 211586009183 von Willebrand factor type A domain; Region: VWA_2; pfam13519 211586009184 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 211586009185 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 211586009186 PilX N-terminal; Region: PilX_N; pfam14341 211586009187 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 211586009188 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 211586009189 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 211586009190 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 211586009191 Fe-S cluster binding site [ion binding]; other site 211586009192 substrate binding site [chemical binding]; other site 211586009193 catalytic site [active] 211586009194 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl19519 211586009195 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 211586009196 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 211586009197 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 211586009198 active site 211586009199 HIGH motif; other site 211586009200 KMSKS motif; other site 211586009201 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 211586009202 tRNA binding surface [nucleotide binding]; other site 211586009203 anticodon binding site; other site 211586009204 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 211586009205 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 211586009206 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 211586009207 active site 211586009208 Riboflavin kinase; Region: Flavokinase; smart00904 211586009209 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 211586009210 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 211586009211 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667 211586009212 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 211586009213 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 211586009214 dimerization interface [polypeptide binding]; other site 211586009215 putative DNA binding site [nucleotide binding]; other site 211586009216 putative Zn2+ binding site [ion binding]; other site 211586009217 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 211586009218 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 211586009219 PA/protease or protease-like domain interface [polypeptide binding]; other site 211586009220 metal binding site [ion binding]; metal-binding site 211586009221 hypothetical protein; Validated; Region: PRK02101 211586009222 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 211586009223 putative phosphoketolase; Provisional; Region: PRK05261 211586009224 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 211586009225 TPP-binding site; other site 211586009226 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 211586009227 XFP C-terminal domain; Region: XFP_C; pfam09363 211586009228 Winged helix-turn helix; Region: HTH_29; pfam13551 211586009229 Helix-turn-helix domain; Region: HTH_28; pfam13518 211586009230 Integrase core domain; Region: rve; pfam00665 211586009231 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 211586009232 Integrase core domain; Region: rve_3; pfam13683 211586009233 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 211586009234 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586009235 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 211586009236 outer membrane protein A; Reviewed; Region: PRK10808 211586009237 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 211586009238 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 211586009239 ligand binding site [chemical binding]; other site 211586009240 transaldolase-like protein; Provisional; Region: PTZ00411 211586009241 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 211586009242 active site 211586009243 dimer interface [polypeptide binding]; other site 211586009244 catalytic residue [active] 211586009245 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 211586009246 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 211586009247 active site 211586009248 dimer interface [polypeptide binding]; other site 211586009249 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 211586009250 dimer interface [polypeptide binding]; other site 211586009251 active site 211586009252 Protein of unknown function (DUF3545); Region: DUF3545; pfam12065 211586009253 Hemerythrin family; Region: Hemerythrin-like; cl15774 211586009254 Fe binding site [ion binding]; other site 211586009255 RNA polymerase sigma factor; Provisional; Region: PRK12513 211586009256 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 211586009257 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 211586009258 DNA binding residues [nucleotide binding] 211586009259 von Willebrand factor; Region: vWF_A; pfam12450 211586009260 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 211586009261 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 211586009262 metal ion-dependent adhesion site (MIDAS); other site 211586009263 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 211586009264 putative transporter; Provisional; Region: PRK11660 211586009265 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 211586009266 Sulfate transporter family; Region: Sulfate_transp; pfam00916 211586009267 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 211586009268 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 211586009269 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 211586009270 ATP-grasp domain; Region: ATP-grasp_4; cl17255 211586009271 GAF domain; Region: GAF_2; pfam13185 211586009272 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586009273 metal binding site [ion binding]; metal-binding site 211586009274 active site 211586009275 I-site; other site 211586009276 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 211586009277 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 211586009278 N-acetyl-D-glucosamine binding site [chemical binding]; other site 211586009279 catalytic residue [active] 211586009280 glutamate--cysteine ligase; Provisional; Region: PRK02107 211586009281 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 211586009282 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 211586009283 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 211586009284 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 211586009285 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 211586009286 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 211586009287 Predicted membrane protein [Function unknown]; Region: COG1238 211586009288 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 211586009289 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 211586009290 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 211586009291 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 211586009292 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 211586009293 active site 211586009294 Zn binding site [ion binding]; other site 211586009295 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 211586009296 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 211586009297 active site 211586009298 metal binding site [ion binding]; metal-binding site 211586009299 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 211586009300 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586009301 Transposase; Region: HTH_Tnp_1; pfam01527 211586009302 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586009303 putative transposase OrfB; Reviewed; Region: PHA02517 211586009304 HTH-like domain; Region: HTH_21; pfam13276 211586009305 Integrase core domain; Region: rve; pfam00665 211586009306 Integrase core domain; Region: rve_2; pfam13333 211586009307 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829 211586009308 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 211586009309 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 211586009310 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 211586009311 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 211586009312 Clp amino terminal domain; Region: Clp_N; pfam02861 211586009313 Clp amino terminal domain; Region: Clp_N; pfam02861 211586009314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586009315 Walker A motif; other site 211586009316 ATP binding site [chemical binding]; other site 211586009317 Walker B motif; other site 211586009318 arginine finger; other site 211586009319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586009320 Walker A motif; other site 211586009321 ATP binding site [chemical binding]; other site 211586009322 Walker B motif; other site 211586009323 arginine finger; other site 211586009324 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 211586009325 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 211586009326 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 211586009327 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211586009328 RNA binding surface [nucleotide binding]; other site 211586009329 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 211586009330 active site 211586009331 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 211586009332 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 211586009333 HAMP domain; Region: HAMP; pfam00672 211586009334 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 211586009335 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 211586009336 dimer interface [polypeptide binding]; other site 211586009337 putative CheW interface [polypeptide binding]; other site 211586009338 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 211586009339 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211586009340 RNA binding surface [nucleotide binding]; other site 211586009341 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 211586009342 active site 211586009343 uracil binding [chemical binding]; other site 211586009344 Predicted transcriptional regulator [Transcription]; Region: COG2345 211586009345 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 211586009346 putative Zn2+ binding site [ion binding]; other site 211586009347 putative DNA binding site [nucleotide binding]; other site 211586009348 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 211586009349 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 211586009350 active site 211586009351 metal binding site [ion binding]; metal-binding site 211586009352 YcxB-like protein; Region: YcxB; pfam14317 211586009353 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 211586009354 MltA-interacting protein MipA; Region: MipA; pfam06629 211586009355 Protein of unknown function (DUF3019); Region: DUF3019; pfam11456 211586009356 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 211586009357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586009358 active site 211586009359 phosphorylation site [posttranslational modification] 211586009360 intermolecular recognition site; other site 211586009361 dimerization interface [polypeptide binding]; other site 211586009362 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211586009363 DNA binding site [nucleotide binding] 211586009364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586009365 dimer interface [polypeptide binding]; other site 211586009366 phosphorylation site [posttranslational modification] 211586009367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586009368 ATP binding site [chemical binding]; other site 211586009369 Mg2+ binding site [ion binding]; other site 211586009370 G-X-G motif; other site 211586009371 Predicted Fe-S protein [General function prediction only]; Region: COG3313 211586009372 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 211586009373 cysteine synthase; Region: PLN02565 211586009374 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 211586009375 dimer interface [polypeptide binding]; other site 211586009376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586009377 catalytic residue [active] 211586009378 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 211586009379 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 211586009380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211586009381 dimer interface [polypeptide binding]; other site 211586009382 conserved gate region; other site 211586009383 putative PBP binding loops; other site 211586009384 ABC-ATPase subunit interface; other site 211586009385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211586009386 dimer interface [polypeptide binding]; other site 211586009387 conserved gate region; other site 211586009388 putative PBP binding loops; other site 211586009389 ABC-ATPase subunit interface; other site 211586009390 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 211586009391 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 211586009392 Walker A/P-loop; other site 211586009393 ATP binding site [chemical binding]; other site 211586009394 Q-loop/lid; other site 211586009395 ABC transporter signature motif; other site 211586009396 Walker B; other site 211586009397 D-loop; other site 211586009398 H-loop/switch region; other site 211586009399 TOBE-like domain; Region: TOBE_3; pfam12857 211586009400 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586009401 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586009402 Transposase; Region: HTH_Tnp_1; pfam01527 211586009403 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586009404 putative transposase OrfB; Reviewed; Region: PHA02517 211586009405 HTH-like domain; Region: HTH_21; pfam13276 211586009406 Integrase core domain; Region: rve; pfam00665 211586009407 Integrase core domain; Region: rve_2; pfam13333 211586009408 Transposase; Region: HTH_Tnp_1; pfam01527 211586009409 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586009410 putative transposase OrfB; Reviewed; Region: PHA02517 211586009411 HTH-like domain; Region: HTH_21; pfam13276 211586009412 Integrase core domain; Region: rve; pfam00665 211586009413 Integrase core domain; Region: rve_2; pfam13333 211586009414 Ycf46; Provisional; Region: ycf46; CHL00195 211586009415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586009416 Walker A motif; other site 211586009417 ATP binding site [chemical binding]; other site 211586009418 Walker B motif; other site 211586009419 arginine finger; other site 211586009420 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 211586009421 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; cl19132 211586009422 ATP-grasp domain; Region: ATP-grasp; pfam02222 211586009423 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 211586009424 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 211586009425 Cupin domain; Region: Cupin_2; pfam07883 211586009426 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 211586009427 heme-binding residues [chemical binding]; other site 211586009428 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586009429 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 211586009430 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211586009431 Sensors of blue-light using FAD; Region: BLUF; smart01034 211586009432 TolA C-terminal; Region: TolA; pfam06519 211586009433 TolA protein; Region: tolA_full; TIGR02794 211586009434 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 211586009435 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 211586009436 putative ligand binding site [chemical binding]; other site 211586009437 putative NAD binding site [chemical binding]; other site 211586009438 catalytic site [active] 211586009439 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 211586009440 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 211586009441 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 211586009442 putative metal binding site [ion binding]; other site 211586009443 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 211586009444 HSP70 interaction site [polypeptide binding]; other site 211586009445 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 211586009446 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 211586009447 Substrate binding site; other site 211586009448 metal-binding site 211586009449 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 211586009450 Phosphotransferase enzyme family; Region: APH; pfam01636 211586009451 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 211586009452 OstA-like protein; Region: OstA; cl00844 211586009453 Organic solvent tolerance protein; Region: OstA_C; pfam04453 211586009454 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 211586009455 SurA N-terminal domain; Region: SurA_N; pfam09312 211586009456 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 211586009457 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 211586009458 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 211586009459 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 211586009460 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 211586009461 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 211586009462 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 211586009463 active site 211586009464 metal binding site [ion binding]; metal-binding site 211586009465 Predicted membrane protein [Function unknown]; Region: COG1511 211586009466 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 211586009467 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586009468 dimerization interface [polypeptide binding]; other site 211586009469 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 211586009470 dimer interface [polypeptide binding]; other site 211586009471 putative CheW interface [polypeptide binding]; other site 211586009472 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 211586009473 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 211586009474 folate binding site [chemical binding]; other site 211586009475 NADP+ binding site [chemical binding]; other site 211586009476 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 211586009477 Uncharacterized conserved protein [Function unknown]; Region: COG2966 211586009478 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 211586009479 GTPase CgtA; Reviewed; Region: obgE; PRK12298 211586009480 GTP1/OBG; Region: GTP1_OBG; pfam01018 211586009481 Obg GTPase; Region: Obg; cd01898 211586009482 G1 box; other site 211586009483 GTP/Mg2+ binding site [chemical binding]; other site 211586009484 Switch I region; other site 211586009485 G2 box; other site 211586009486 G3 box; other site 211586009487 Switch II region; other site 211586009488 G4 box; other site 211586009489 G5 box; other site 211586009490 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 211586009491 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 211586009492 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 211586009493 substrate binding pocket [chemical binding]; other site 211586009494 chain length determination region; other site 211586009495 substrate-Mg2+ binding site; other site 211586009496 catalytic residues [active] 211586009497 aspartate-rich region 1; other site 211586009498 active site lid residues [active] 211586009499 aspartate-rich region 2; other site 211586009500 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 211586009501 ligand binding site [chemical binding]; other site 211586009502 active site 211586009503 UGI interface [polypeptide binding]; other site 211586009504 catalytic site [active] 211586009505 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 211586009506 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 211586009507 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 211586009508 DsbD alpha interface [polypeptide binding]; other site 211586009509 catalytic residues [active] 211586009510 PAS domain S-box; Region: sensory_box; TIGR00229 211586009511 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586009512 putative active site [active] 211586009513 heme pocket [chemical binding]; other site 211586009514 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 211586009515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586009516 Walker A motif; other site 211586009517 ATP binding site [chemical binding]; other site 211586009518 Walker B motif; other site 211586009519 arginine finger; other site 211586009520 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 211586009521 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 211586009522 4Fe-4S binding domain; Region: Fer4_5; pfam12801 211586009523 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 211586009524 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 211586009525 IG-like fold at C-terminal of FixG, putative oxidoreductase; Region: FixG_C; pfam11614 211586009526 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 211586009527 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 211586009528 acyl-activating enzyme (AAE) consensus motif; other site 211586009529 putative AMP binding site [chemical binding]; other site 211586009530 putative active site [active] 211586009531 putative CoA binding site [chemical binding]; other site 211586009532 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 211586009533 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211586009534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211586009535 Walker A/P-loop; other site 211586009536 ATP binding site [chemical binding]; other site 211586009537 Q-loop/lid; other site 211586009538 ABC transporter signature motif; other site 211586009539 Walker B; other site 211586009540 D-loop; other site 211586009541 H-loop/switch region; other site 211586009542 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 211586009543 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 211586009544 putative heme utilization carrier protein HutX; Region: HutX; TIGR04108 211586009545 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 211586009546 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 211586009547 N-terminal plug; other site 211586009548 ligand-binding site [chemical binding]; other site 211586009549 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 211586009550 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 211586009551 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 211586009552 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 211586009553 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 211586009554 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 211586009555 putative hemin binding site; other site 211586009556 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 211586009557 ABC-ATPase subunit interface; other site 211586009558 dimer interface [polypeptide binding]; other site 211586009559 putative PBP binding regions; other site 211586009560 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 211586009561 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 211586009562 Walker A/P-loop; other site 211586009563 ATP binding site [chemical binding]; other site 211586009564 Q-loop/lid; other site 211586009565 ABC transporter signature motif; other site 211586009566 Walker B; other site 211586009567 D-loop; other site 211586009568 H-loop/switch region; other site 211586009569 Protein of unknown function (DUF2956); Region: DUF2956; pfam11169 211586009570 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 211586009571 FAD dependent oxidoreductase; Region: DAO; pfam01266 211586009572 Winged helix-turn helix; Region: HTH_43; pfam09904 211586009573 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 211586009574 Ligand Binding Site [chemical binding]; other site 211586009575 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 211586009576 Ligand Binding Site [chemical binding]; other site 211586009577 SpoIIAA-like; Region: SpoIIAA-like; pfam11964 211586009578 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 211586009579 NAD(P) binding site [chemical binding]; other site 211586009580 catalytic residues [active] 211586009581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 211586009582 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211586009583 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 211586009584 Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082 211586009585 Curli assembly protein CsgE; Region: CsgE; pfam10627 211586009586 HAMP domain; Region: HAMP; pfam00672 211586009587 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 211586009588 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 211586009589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586009590 ATP binding site [chemical binding]; other site 211586009591 Mg2+ binding site [ion binding]; other site 211586009592 G-X-G motif; other site 211586009593 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 211586009594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586009595 active site 211586009596 phosphorylation site [posttranslational modification] 211586009597 intermolecular recognition site; other site 211586009598 dimerization interface [polypeptide binding]; other site 211586009599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586009600 Walker A motif; other site 211586009601 ATP binding site [chemical binding]; other site 211586009602 Walker B motif; other site 211586009603 arginine finger; other site 211586009604 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 211586009605 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 211586009606 FtsX-like permease family; Region: FtsX; pfam02687 211586009607 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 211586009608 FtsX-like permease family; Region: FtsX; pfam02687 211586009609 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 211586009610 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 211586009611 Walker A/P-loop; other site 211586009612 ATP binding site [chemical binding]; other site 211586009613 Q-loop/lid; other site 211586009614 ABC transporter signature motif; other site 211586009615 Walker B; other site 211586009616 D-loop; other site 211586009617 H-loop/switch region; other site 211586009618 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 211586009619 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586009620 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 211586009621 active site 211586009622 substrate binding pocket [chemical binding]; other site 211586009623 dimer interface [polypeptide binding]; other site 211586009624 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 211586009625 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 211586009626 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211586009627 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211586009628 substrate binding pocket [chemical binding]; other site 211586009629 membrane-bound complex binding site; other site 211586009630 hinge residues; other site 211586009631 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586009632 metal binding site [ion binding]; metal-binding site 211586009633 active site 211586009634 I-site; other site 211586009635 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 211586009636 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 211586009637 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 211586009638 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 211586009639 Nucleoside recognition; Region: Gate; pfam07670 211586009640 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 211586009641 MAPEG family; Region: MAPEG; cl09190 211586009642 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 211586009643 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 211586009644 cobalamin binding residues [chemical binding]; other site 211586009645 putative BtuC binding residues; other site 211586009646 dimer interface [polypeptide binding]; other site 211586009647 Uncharacterized alpha/beta hydrolase domain (DUF2235); Region: DUF2235; pfam09994 211586009648 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586009649 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586009650 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 211586009651 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 211586009652 ligand binding site [chemical binding]; other site 211586009653 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 211586009654 dimer interface [polypeptide binding]; other site 211586009655 FMN binding site [chemical binding]; other site 211586009656 DNA-J related protein; Region: DNAJ_related; pfam12339 211586009657 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 211586009658 HSP70 interaction site [polypeptide binding]; other site 211586009659 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 211586009660 catalytic residues [active] 211586009661 hinge region; other site 211586009662 alpha helical domain; other site 211586009663 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 211586009664 Flavodoxin domain; Region: Flavodoxin_5; cl17428 211586009665 TIGR03899 family protein; Region: TIGR03899 211586009666 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 211586009667 ligand-binding site [chemical binding]; other site 211586009668 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 211586009669 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 211586009670 CysD dimerization site [polypeptide binding]; other site 211586009671 G1 box; other site 211586009672 putative GEF interaction site [polypeptide binding]; other site 211586009673 GTP/Mg2+ binding site [chemical binding]; other site 211586009674 Switch I region; other site 211586009675 G2 box; other site 211586009676 G3 box; other site 211586009677 Switch II region; other site 211586009678 G4 box; other site 211586009679 G5 box; other site 211586009680 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 211586009681 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 211586009682 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 211586009683 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 211586009684 Active Sites [active] 211586009685 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 211586009686 active site 211586009687 SAM binding site [chemical binding]; other site 211586009688 homodimer interface [polypeptide binding]; other site 211586009689 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 211586009690 Active site serine [active] 211586009691 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 211586009692 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 211586009693 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 211586009694 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 211586009695 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 211586009696 Active Sites [active] 211586009697 sulfite reductase subunit beta; Provisional; Region: PRK13504 211586009698 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 211586009699 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 211586009700 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 211586009701 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 211586009702 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 211586009703 Flavodoxin; Region: Flavodoxin_1; pfam00258 211586009704 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 211586009705 FAD binding pocket [chemical binding]; other site 211586009706 FAD binding motif [chemical binding]; other site 211586009707 catalytic residues [active] 211586009708 NAD binding pocket [chemical binding]; other site 211586009709 phosphate binding motif [ion binding]; other site 211586009710 beta-alpha-beta structure motif; other site 211586009711 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 211586009712 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 211586009713 ligand binding site [chemical binding]; other site 211586009714 homodimer interface [polypeptide binding]; other site 211586009715 NAD(P) binding site [chemical binding]; other site 211586009716 trimer interface B [polypeptide binding]; other site 211586009717 trimer interface A [polypeptide binding]; other site 211586009718 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 211586009719 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 211586009720 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 211586009721 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 211586009722 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 211586009723 putative ribose interaction site [chemical binding]; other site 211586009724 putative ADP binding site [chemical binding]; other site 211586009725 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 211586009726 active site 211586009727 nucleotide binding site [chemical binding]; other site 211586009728 HIGH motif; other site 211586009729 KMSKS motif; other site 211586009730 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 211586009731 putative acyl-acceptor binding pocket; other site 211586009732 potassium/proton antiporter; Reviewed; Region: PRK05326 211586009733 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 211586009734 TrkA-C domain; Region: TrkA_C; pfam02080 211586009735 Transporter associated domain; Region: CorC_HlyC; smart01091 211586009736 L,D-transpeptidase; Provisional; Region: PRK10260 211586009737 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 211586009738 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 211586009739 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 211586009740 putative active site [active] 211586009741 Zn binding site [ion binding]; other site 211586009742 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 211586009743 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 211586009744 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 211586009745 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586009746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586009747 Predicted ATPase [General function prediction only]; Region: COG1485 211586009748 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 211586009749 Walker A/P-loop; other site 211586009750 ATP binding site [chemical binding]; other site 211586009751 ABC transporter signature motif; other site 211586009752 Walker B; other site 211586009753 D-loop; other site 211586009754 H-loop/switch region; other site 211586009755 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586009756 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 211586009757 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 211586009758 dimerization interface [polypeptide binding]; other site 211586009759 Domain of unknown function (DUF897); Region: DUF897; pfam05982 211586009760 GAF domain; Region: GAF; pfam01590 211586009761 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586009762 metal binding site [ion binding]; metal-binding site 211586009763 active site 211586009764 I-site; other site 211586009765 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 211586009766 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 211586009767 metal binding triad; other site 211586009768 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 211586009769 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 211586009770 metal binding triad; other site 211586009771 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 211586009772 spermidine synthase; Provisional; Region: PRK03612 211586009773 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938 211586009774 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 211586009775 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 211586009776 oligomer interface [polypeptide binding]; other site 211586009777 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 211586009778 Ion transport protein; Region: Ion_trans; pfam00520 211586009779 Ion channel; Region: Ion_trans_2; pfam07885 211586009780 Uncharacterized conserved protein [Function unknown]; Region: COG3025 211586009781 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 211586009782 putative active site [active] 211586009783 putative metal binding residues [ion binding]; other site 211586009784 signature motif; other site 211586009785 putative triphosphate binding site [ion binding]; other site 211586009786 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 211586009787 TIGR00153 family protein; Region: TIGR00153 211586009788 Phosphate transporter family; Region: PHO4; pfam01384 211586009789 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 211586009790 Bacterial SH3 domain; Region: SH3_3; pfam08239 211586009791 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 211586009792 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 211586009793 DNA-binding domain of Proline dehydrogenase; Region: Pro_dh-DNA_bdg; pfam14850 211586009794 Proline dehydrogenase; Region: Pro_dh; pfam01619 211586009795 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 211586009796 Glutamate binding site [chemical binding]; other site 211586009797 NAD binding site [chemical binding]; other site 211586009798 catalytic residues [active] 211586009799 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 211586009800 Protein of unknown function, DUF599; Region: DUF599; pfam04654 211586009801 Helix-turn-helix domain; Region: HTH_17; pfam12728 211586009802 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 211586009803 putative active site [active] 211586009804 putative metal binding residues [ion binding]; other site 211586009805 signature motif; other site 211586009806 putative triphosphate binding site [ion binding]; other site 211586009807 dimer interface [polypeptide binding]; other site 211586009808 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 211586009809 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 211586009810 Walker A/P-loop; other site 211586009811 ATP binding site [chemical binding]; other site 211586009812 Q-loop/lid; other site 211586009813 ABC transporter signature motif; other site 211586009814 Walker B; other site 211586009815 D-loop; other site 211586009816 H-loop/switch region; other site 211586009817 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 211586009818 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211586009819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211586009820 Walker A/P-loop; other site 211586009821 ATP binding site [chemical binding]; other site 211586009822 Q-loop/lid; other site 211586009823 ABC transporter signature motif; other site 211586009824 Walker B; other site 211586009825 D-loop; other site 211586009826 H-loop/switch region; other site 211586009827 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 211586009828 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 211586009829 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 211586009830 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 211586009831 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 211586009832 ATP binding site [chemical binding]; other site 211586009833 Mg++ binding site [ion binding]; other site 211586009834 motif III; other site 211586009835 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586009836 nucleotide binding region [chemical binding]; other site 211586009837 ATP-binding site [chemical binding]; other site 211586009838 Facioscapulohumeral muscular dystrophy candidate 2; Region: FRG2; pfam15315 211586009839 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 211586009840 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 211586009841 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 211586009842 catalytic residue [active] 211586009843 Fe-S metabolizm associated domain; Region: SufE; cl00951 211586009844 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 211586009845 active site 211586009846 Predicted ATPase [General function prediction only]; Region: COG4637 211586009847 AAA domain; Region: AAA_23; pfam13476 211586009848 Walker A/P-loop; other site 211586009849 ATP binding site [chemical binding]; other site 211586009850 AAA domain; Region: AAA_21; pfam13304 211586009851 Cupin domain; Region: Cupin_2; cl17218 211586009852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 211586009853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 211586009854 CAAX protease self-immunity; Region: Abi; pfam02517 211586009855 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 211586009856 pentamer interface [polypeptide binding]; other site 211586009857 dodecaamer interface [polypeptide binding]; other site 211586009858 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 211586009859 Collagenase; Region: DUF3656; pfam12392 211586009860 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 211586009861 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 211586009862 active site 211586009863 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 211586009864 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 211586009865 putative DNA binding site [nucleotide binding]; other site 211586009866 putative Zn2+ binding site [ion binding]; other site 211586009867 AsnC family; Region: AsnC_trans_reg; pfam01037 211586009868 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 211586009869 Subtilase family; Region: Peptidase_S8; pfam00082 211586009870 active site 211586009871 catalytic residues [active] 211586009872 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 211586009873 PA/protease or protease-like domain interface [polypeptide binding]; other site 211586009874 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 211586009875 inner membrane transport permease; Provisional; Region: PRK15066 211586009876 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 211586009877 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 211586009878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211586009879 Walker A/P-loop; other site 211586009880 ATP binding site [chemical binding]; other site 211586009881 Q-loop/lid; other site 211586009882 ABC transporter signature motif; other site 211586009883 Walker B; other site 211586009884 D-loop; other site 211586009885 H-loop/switch region; other site 211586009886 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211586009887 active site 211586009888 aromatic acid decarboxylase; Validated; Region: PRK05920 211586009889 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 211586009890 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 211586009891 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 211586009892 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 211586009893 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 211586009894 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 211586009895 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 211586009896 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 211586009897 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 211586009898 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 211586009899 substrate binding site [chemical binding]; other site 211586009900 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 211586009901 muropeptide transporter; Reviewed; Region: ampG; cl17669 211586009902 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 211586009903 Predicted integral membrane protein [Function unknown]; Region: COG5652 211586009904 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 211586009905 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 211586009906 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 211586009907 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 211586009908 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 211586009909 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586009910 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 211586009911 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586009912 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586009913 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 211586009914 Protein of unknown function (DUF819); Region: DUF819; cl02317 211586009915 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 211586009916 Tetratricopeptide repeat; Region: TPR_9; pfam13371 211586009917 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 211586009918 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586009919 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 211586009920 Coenzyme A binding pocket [chemical binding]; other site 211586009921 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 211586009922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586009923 S-adenosylmethionine binding site [chemical binding]; other site 211586009924 peptide chain release factor 1; Validated; Region: prfA; PRK00591 211586009925 This domain is found in peptide chain release factors; Region: PCRF; smart00937 211586009926 RF-1 domain; Region: RF-1; pfam00472 211586009927 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 211586009928 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 211586009929 tRNA; other site 211586009930 putative tRNA binding site [nucleotide binding]; other site 211586009931 putative NADP binding site [chemical binding]; other site 211586009932 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 211586009933 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 211586009934 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 211586009935 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 211586009936 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 211586009937 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 211586009938 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211586009939 active site 211586009940 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 211586009941 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586009942 dimerization interface [polypeptide binding]; other site 211586009943 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 211586009944 dimer interface [polypeptide binding]; other site 211586009945 putative CheW interface [polypeptide binding]; other site 211586009946 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 211586009947 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 211586009948 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 211586009949 DNA binding residues [nucleotide binding] 211586009950 Domain of unknown function (DUF4098); Region: DUF4098; cl19992 211586009951 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 211586009952 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 211586009953 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 211586009954 RNA binding surface [nucleotide binding]; other site 211586009955 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 211586009956 active site 211586009957 uracil binding [chemical binding]; other site 211586009958 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 211586009959 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 211586009960 active site 211586009961 Zn binding site [ion binding]; other site 211586009962 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 211586009963 synthetase active site [active] 211586009964 NTP binding site [chemical binding]; other site 211586009965 metal binding site [ion binding]; metal-binding site 211586009966 SMI1-KNR4 cell-wall; Region: SUKH_5; pfam14567 211586009967 Domain of unknown function (DUF4447); Region: DUF4447; pfam14590 211586009968 Bacterial PH domain; Region: bPH_2; pfam03703 211586009969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 211586009970 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 211586009971 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 211586009972 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 211586009973 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586009974 malate dehydrogenase; Provisional; Region: PRK13529 211586009975 Malic enzyme, N-terminal domain; Region: malic; pfam00390 211586009976 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 211586009977 NAD(P) binding site [chemical binding]; other site 211586009978 Protein of unknown function (DUF3069); Region: DUF3069; pfam11269 211586009979 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 211586009980 active site 211586009981 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 211586009982 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586009983 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586009984 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586009985 binding surface 211586009986 TPR motif; other site 211586009987 Tetratricopeptide repeat; Region: TPR_12; pfam13424 211586009988 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586009989 TPR motif; other site 211586009990 binding surface 211586009991 Tetratricopeptide repeat; Region: TPR_12; pfam13424 211586009992 Tetratricopeptide repeat; Region: TPR_12; pfam13424 211586009993 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586009994 binding surface 211586009995 TPR motif; other site 211586009996 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586009997 metal binding site [ion binding]; metal-binding site 211586009998 active site 211586009999 I-site; other site 211586010000 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211586010001 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211586010002 substrate binding pocket [chemical binding]; other site 211586010003 membrane-bound complex binding site; other site 211586010004 hinge residues; other site 211586010005 epoxyqueuosine reductase; Region: TIGR00276 211586010006 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 211586010007 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 211586010008 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 211586010009 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 211586010010 TOBE domain; Region: TOBE; cl01440 211586010011 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 211586010012 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 211586010013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211586010014 dimer interface [polypeptide binding]; other site 211586010015 conserved gate region; other site 211586010016 putative PBP binding loops; other site 211586010017 ABC-ATPase subunit interface; other site 211586010018 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 211586010019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211586010020 Walker A/P-loop; other site 211586010021 ATP binding site [chemical binding]; other site 211586010022 Q-loop/lid; other site 211586010023 ABC transporter signature motif; other site 211586010024 Walker B; other site 211586010025 D-loop; other site 211586010026 H-loop/switch region; other site 211586010027 TOBE domain; Region: TOBE; cl01440 211586010028 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 211586010029 active site 211586010030 catalytic residues [active] 211586010031 DNA binding site [nucleotide binding] 211586010032 Int/Topo IB signature motif; other site 211586010033 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211586010034 non-specific DNA binding site [nucleotide binding]; other site 211586010035 salt bridge; other site 211586010036 sequence-specific DNA binding site [nucleotide binding]; other site 211586010037 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 211586010038 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 211586010039 catalytic residues [active] 211586010040 hinge region; other site 211586010041 alpha helical domain; other site 211586010042 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 211586010043 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 211586010044 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586010045 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 211586010046 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 211586010047 dimerization interface [polypeptide binding]; other site 211586010048 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586010049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586010050 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586010051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586010052 Winged helix-turn helix; Region: HTH_29; pfam13551 211586010053 Helix-turn-helix domain; Region: HTH_28; pfam13518 211586010054 Integrase core domain; Region: rve; pfam00665 211586010055 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 211586010056 Integrase core domain; Region: rve_3; pfam13683 211586010057 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586010058 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586010059 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 211586010060 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 211586010061 active site 211586010062 DNA binding site [nucleotide binding] 211586010063 Int/Topo IB signature motif; other site 211586010064 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 211586010065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586010066 Walker A motif; other site 211586010067 ATP binding site [chemical binding]; other site 211586010068 Walker B motif; other site 211586010069 arginine finger; other site 211586010070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586010071 Walker A motif; other site 211586010072 ATP binding site [chemical binding]; other site 211586010073 Walker B motif; other site 211586010074 arginine finger; other site 211586010075 Protein of unknown function (DUF2787); Region: DUF2787; pfam10980 211586010076 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 211586010077 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 211586010078 HAMP domain; Region: HAMP; pfam00672 211586010079 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 211586010080 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 211586010081 dimer interface [polypeptide binding]; other site 211586010082 putative CheW interface [polypeptide binding]; other site 211586010083 Hemerythrin; Region: Hemerythrin; cd12107 211586010084 Fe binding site [ion binding]; other site 211586010085 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 211586010086 Superinfection exclusion protein B; Region: SieB; pfam14163 211586010087 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 211586010088 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 211586010089 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586010090 dimer interface [polypeptide binding]; other site 211586010091 phosphorylation site [posttranslational modification] 211586010092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586010093 ATP binding site [chemical binding]; other site 211586010094 Mg2+ binding site [ion binding]; other site 211586010095 G-X-G motif; other site 211586010096 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 211586010097 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 211586010098 putative ATP binding site [chemical binding]; other site 211586010099 putative substrate interface [chemical binding]; other site 211586010100 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 211586010101 eyelet of channel; other site 211586010102 trimer interface [polypeptide binding]; other site 211586010103 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 211586010104 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 211586010105 CAP-like domain; other site 211586010106 active site 211586010107 primary dimer interface [polypeptide binding]; other site 211586010108 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 211586010109 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 211586010110 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 211586010111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586010112 ATP binding site [chemical binding]; other site 211586010113 Mg2+ binding site [ion binding]; other site 211586010114 G-X-G motif; other site 211586010115 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 211586010116 anchoring element; other site 211586010117 dimer interface [polypeptide binding]; other site 211586010118 ATP binding site [chemical binding]; other site 211586010119 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 211586010120 active site 211586010121 metal binding site [ion binding]; metal-binding site 211586010122 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 211586010123 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 211586010124 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 211586010125 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 211586010126 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 211586010127 active site 211586010128 metal binding site [ion binding]; metal-binding site 211586010129 hexamer interface [polypeptide binding]; other site 211586010130 Protein of unknown function (DUF1249); Region: DUF1249; pfam06853 211586010131 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 211586010132 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 211586010133 dimer interface [polypeptide binding]; other site 211586010134 ADP-ribose binding site [chemical binding]; other site 211586010135 active site 211586010136 nudix motif; other site 211586010137 metal binding site [ion binding]; metal-binding site 211586010138 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 211586010139 Outer membrane efflux protein; Region: OEP; pfam02321 211586010140 Outer membrane efflux protein; Region: OEP; pfam02321 211586010141 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 211586010142 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 211586010143 Protein of unknown function (DUF461); Region: DUF461; pfam04314 211586010144 enoyl-CoA hydratase; Provisional; Region: PRK06688 211586010145 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 211586010146 substrate binding site [chemical binding]; other site 211586010147 oxyanion hole (OAH) forming residues; other site 211586010148 trimer interface [polypeptide binding]; other site 211586010149 PspC domain; Region: PspC; pfam04024 211586010150 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 211586010151 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 211586010152 FMN binding site [chemical binding]; other site 211586010153 active site 211586010154 catalytic residues [active] 211586010155 substrate binding site [chemical binding]; other site 211586010156 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 211586010157 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 211586010158 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 211586010159 N-terminal plug; other site 211586010160 ligand-binding site [chemical binding]; other site 211586010161 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 211586010162 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 211586010163 alanine racemase; Reviewed; Region: alr; PRK00053 211586010164 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 211586010165 active site 211586010166 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 211586010167 substrate binding site [chemical binding]; other site 211586010168 catalytic residues [active] 211586010169 dimer interface [polypeptide binding]; other site 211586010170 replicative DNA helicase; Provisional; Region: PRK08006 211586010171 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 211586010172 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 211586010173 Walker A motif; other site 211586010174 ATP binding site [chemical binding]; other site 211586010175 Walker B motif; other site 211586010176 DNA binding loops [nucleotide binding] 211586010177 Peptidase S46; Region: Peptidase_S46; pfam10459 211586010178 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 211586010179 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 211586010180 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 211586010181 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 211586010182 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 211586010183 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 211586010184 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211586010185 FeS/SAM binding site; other site 211586010186 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 211586010187 biotin synthase; Provisional; Region: PRK07094 211586010188 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211586010189 FeS/SAM binding site; other site 211586010190 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 211586010191 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 211586010192 G1 box; other site 211586010193 GTP/Mg2+ binding site [chemical binding]; other site 211586010194 Switch I region; other site 211586010195 G2 box; other site 211586010196 Switch II region; other site 211586010197 G3 box; other site 211586010198 G4 box; other site 211586010199 G5 box; other site 211586010200 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 211586010201 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 211586010202 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 211586010203 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 211586010204 primosomal replication protein N; Provisional; Region: PRK02801 211586010205 generic binding surface II; other site 211586010206 generic binding surface I; other site 211586010207 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 211586010208 Protein of unknown function, DUF481; Region: DUF481; pfam04338 211586010209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586010210 putative MFS family transporter protein; Provisional; Region: PRK03633 211586010211 putative substrate translocation pore; other site 211586010212 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 211586010213 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 211586010214 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 211586010215 exoribonuclease R; Provisional; Region: PRK11642 211586010216 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 211586010217 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 211586010218 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 211586010219 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 211586010220 RNA binding site [nucleotide binding]; other site 211586010221 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 211586010222 Sel1-like repeats; Region: SEL1; smart00671 211586010223 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 211586010224 GDP-binding site [chemical binding]; other site 211586010225 ACT binding site; other site 211586010226 IMP binding site; other site 211586010227 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 211586010228 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 211586010229 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 211586010230 23S rRNA interface [nucleotide binding]; other site 211586010231 L3 interface [polypeptide binding]; other site 211586010232 Predicted ATPase [General function prediction only]; Region: COG1485 211586010233 serine endoprotease; Provisional; Region: PRK10942 211586010234 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 211586010235 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 211586010236 protein binding site [polypeptide binding]; other site 211586010237 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 211586010238 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 211586010239 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 211586010240 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 211586010241 protein binding site [polypeptide binding]; other site 211586010242 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586010243 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586010244 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 211586010245 Transposase; Region: DEDD_Tnp_IS110; pfam01548 211586010246 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 211586010247 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 211586010248 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 211586010249 hinge; other site 211586010250 active site 211586010251 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 211586010252 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 211586010253 anti sigma factor interaction site; other site 211586010254 regulatory phosphorylation site [posttranslational modification]; other site 211586010255 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 211586010256 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 211586010257 mce related protein; Region: MCE; pfam02470 211586010258 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 211586010259 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 211586010260 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 211586010261 Walker A/P-loop; other site 211586010262 ATP binding site [chemical binding]; other site 211586010263 Q-loop/lid; other site 211586010264 ABC transporter signature motif; other site 211586010265 Walker B; other site 211586010266 D-loop; other site 211586010267 H-loop/switch region; other site 211586010268 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 211586010269 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 211586010270 putative active site [active] 211586010271 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 211586010272 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211586010273 active site 211586010274 motif I; other site 211586010275 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 211586010276 motif II; other site 211586010277 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 211586010278 OstA-like protein; Region: OstA; cl00844 211586010279 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 211586010280 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 211586010281 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 211586010282 Walker A/P-loop; other site 211586010283 ATP binding site [chemical binding]; other site 211586010284 Q-loop/lid; other site 211586010285 ABC transporter signature motif; other site 211586010286 Walker B; other site 211586010287 D-loop; other site 211586010288 H-loop/switch region; other site 211586010289 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 211586010290 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 211586010291 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 211586010292 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 211586010293 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 211586010294 30S subunit binding site; other site 211586010295 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 211586010296 active site 211586010297 phosphorylation site [posttranslational modification] 211586010298 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 211586010299 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 211586010300 dimerization domain swap beta strand [polypeptide binding]; other site 211586010301 regulatory protein interface [polypeptide binding]; other site 211586010302 active site 211586010303 regulatory phosphorylation site [posttranslational modification]; other site 211586010304 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 211586010305 MgtE intracellular N domain; Region: MgtE_N; smart00924 211586010306 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 211586010307 Divalent cation transporter; Region: MgtE; cl00786 211586010308 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 211586010309 putative outer membrane lipoprotein; Provisional; Region: PRK10510 211586010310 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 211586010311 ligand binding site [chemical binding]; other site 211586010312 Transposase; Region: HTH_Tnp_1; cl17663 211586010313 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 211586010314 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 211586010315 ATP binding site [chemical binding]; other site 211586010316 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 211586010317 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 211586010318 active site 211586010319 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 211586010320 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 211586010321 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 211586010322 HAMP domain; Region: HAMP; pfam00672 211586010323 Histidine kinase; Region: HisKA_3; pfam07730 211586010324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586010325 ATP binding site [chemical binding]; other site 211586010326 Mg2+ binding site [ion binding]; other site 211586010327 G-X-G motif; other site 211586010328 transcriptional regulator NarL; Provisional; Region: PRK10651 211586010329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586010330 active site 211586010331 phosphorylation site [posttranslational modification] 211586010332 intermolecular recognition site; other site 211586010333 dimerization interface [polypeptide binding]; other site 211586010334 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 211586010335 DNA binding residues [nucleotide binding] 211586010336 dimerization interface [polypeptide binding]; other site 211586010337 Uncharacterized protein family (UPF0231); Region: UPF0231; pfam06062 211586010338 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 211586010339 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 211586010340 Cl binding site [ion binding]; other site 211586010341 oligomer interface [polypeptide binding]; other site 211586010342 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 211586010343 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 211586010344 active site 211586010345 Zn binding site [ion binding]; other site 211586010346 aspartate kinase III; Validated; Region: PRK09084 211586010347 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 211586010348 nucleotide binding site [chemical binding]; other site 211586010349 substrate binding site [chemical binding]; other site 211586010350 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 211586010351 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 211586010352 dimer interface [polypeptide binding]; other site 211586010353 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 211586010354 two-component response regulator; Provisional; Region: PRK11173 211586010355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586010356 active site 211586010357 phosphorylation site [posttranslational modification] 211586010358 intermolecular recognition site; other site 211586010359 dimerization interface [polypeptide binding]; other site 211586010360 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211586010361 DNA binding site [nucleotide binding] 211586010362 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 211586010363 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 211586010364 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 211586010365 AMP binding site [chemical binding]; other site 211586010366 metal binding site [ion binding]; metal-binding site 211586010367 active site 211586010368 hypothetical protein; Provisional; Region: PRK05208 211586010369 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586010370 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 211586010371 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 211586010372 ligand binding site [chemical binding]; other site 211586010373 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211586010374 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211586010375 substrate binding pocket [chemical binding]; other site 211586010376 membrane-bound complex binding site; other site 211586010377 hinge residues; other site 211586010378 PAS domain; Region: PAS_8; pfam13188 211586010379 PAS domain; Region: PAS_9; pfam13426 211586010380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586010381 dimer interface [polypeptide binding]; other site 211586010382 phosphorylation site [posttranslational modification] 211586010383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586010384 ATP binding site [chemical binding]; other site 211586010385 Mg2+ binding site [ion binding]; other site 211586010386 G-X-G motif; other site 211586010387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586010388 active site 211586010389 phosphorylation site [posttranslational modification] 211586010390 intermolecular recognition site; other site 211586010391 dimerization interface [polypeptide binding]; other site 211586010392 Hpt domain; Region: Hpt; pfam01627 211586010393 putative binding surface; other site 211586010394 active site 211586010395 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 211586010396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586010397 active site 211586010398 phosphorylation site [posttranslational modification] 211586010399 intermolecular recognition site; other site 211586010400 dimerization interface [polypeptide binding]; other site 211586010401 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211586010402 Zn2+ binding site [ion binding]; other site 211586010403 Mg2+ binding site [ion binding]; other site 211586010404 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 211586010405 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 211586010406 active site 211586010407 metal binding site [ion binding]; metal-binding site 211586010408 Pleckstrin homology-like domain; Region: PH-like; cl17171 211586010409 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 211586010410 Protein of unknown function (DUF3581); Region: DUF3581; pfam12119 211586010411 Phage shock protein B; Region: PspB; cl05946 211586010412 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 211586010413 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 211586010414 MMPL family; Region: MMPL; cl14618 211586010415 MMPL family; Region: MMPL; cl14618 211586010416 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 211586010417 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586010418 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 211586010419 Leucine rich repeat; Region: LRR_8; pfam13855 211586010420 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 211586010421 Substrate binding site [chemical binding]; other site 211586010422 Leucine rich repeat; Region: LRR_8; pfam13855 211586010423 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 211586010424 active site 211586010425 ATP binding site [chemical binding]; other site 211586010426 substrate binding site [chemical binding]; other site 211586010427 activation loop (A-loop); other site 211586010428 MltD lipid attachment motif; Region: MLTD_N; pfam06474 211586010429 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 211586010430 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 211586010431 N-acetyl-D-glucosamine binding site [chemical binding]; other site 211586010432 catalytic residue [active] 211586010433 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 211586010434 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 211586010435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586010436 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 211586010437 Walker A motif; other site 211586010438 ATP binding site [chemical binding]; other site 211586010439 AAA domain; Region: AAA_12; pfam13087 211586010440 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 211586010441 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586010442 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 211586010443 substrate binding pocket [chemical binding]; other site 211586010444 dimerization interface [polypeptide binding]; other site 211586010445 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 211586010446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586010447 putative substrate translocation pore; other site 211586010448 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 211586010449 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 211586010450 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 211586010451 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 211586010452 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 211586010453 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586010454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586010455 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 211586010456 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 211586010457 dimer interface [polypeptide binding]; other site 211586010458 ssDNA binding site [nucleotide binding]; other site 211586010459 tetramer (dimer of dimers) interface [polypeptide binding]; other site 211586010460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586010461 Major Facilitator Superfamily; Region: MFS_1; pfam07690 211586010462 putative substrate translocation pore; other site 211586010463 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 211586010464 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 211586010465 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 211586010466 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 211586010467 M28 Zn-Peptidases; Region: M28_like_2; cd05662 211586010468 metal binding site [ion binding]; metal-binding site 211586010469 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 211586010470 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 211586010471 ATP binding site [chemical binding]; other site 211586010472 Mg++ binding site [ion binding]; other site 211586010473 motif III; other site 211586010474 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586010475 nucleotide binding region [chemical binding]; other site 211586010476 ATP-binding site [chemical binding]; other site 211586010477 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 211586010478 putative RNA binding site [nucleotide binding]; other site 211586010479 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 211586010480 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211586010481 active site 211586010482 motif I; other site 211586010483 motif II; other site 211586010484 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 211586010485 EamA-like transporter family; Region: EamA; pfam00892 211586010486 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 211586010487 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914 211586010488 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 211586010489 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 211586010490 Cytochrome c [Energy production and conversion]; Region: COG3258 211586010491 Cytochrome c; Region: Cytochrom_C; pfam00034 211586010492 Cytochrome c; Region: Cytochrom_C; cl11414 211586010493 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 211586010494 Cytochrome c; Region: Cytochrom_C; cl11414 211586010495 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 211586010496 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 211586010497 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 211586010498 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586010499 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 211586010500 Transcriptional regulators [Transcription]; Region: MarR; COG1846 211586010501 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586010502 dimerization interface [polypeptide binding]; other site 211586010503 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 211586010504 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 211586010505 dimer interface [polypeptide binding]; other site 211586010506 putative CheW interface [polypeptide binding]; other site 211586010507 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 211586010508 FAD binding site [chemical binding]; other site 211586010509 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 211586010510 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 211586010511 putative catalytic residues [active] 211586010512 putative nucleotide binding site [chemical binding]; other site 211586010513 putative aspartate binding site [chemical binding]; other site 211586010514 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 211586010515 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 211586010516 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 211586010517 homodimer interface [polypeptide binding]; other site 211586010518 substrate-cofactor binding pocket; other site 211586010519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586010520 catalytic residue [active] 211586010521 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 211586010522 dimerization interface [polypeptide binding]; other site 211586010523 DNA binding site [nucleotide binding] 211586010524 corepressor binding sites; other site 211586010525 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 211586010526 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 211586010527 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 211586010528 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 211586010529 thiosulfate reductase PhsA; Provisional; Region: PRK15488 211586010530 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 211586010531 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 211586010532 putative [Fe4-S4] binding site [ion binding]; other site 211586010533 putative molybdopterin cofactor binding site [chemical binding]; other site 211586010534 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 211586010535 putative molybdopterin cofactor binding site; other site 211586010536 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 211586010537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 211586010538 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 211586010539 ATP binding site [chemical binding]; other site 211586010540 active site 211586010541 substrate binding site [chemical binding]; other site 211586010542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586010543 S-adenosylmethionine binding site [chemical binding]; other site 211586010544 oxidative stress defense protein; Provisional; Region: PRK11087 211586010545 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 211586010546 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 211586010547 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211586010548 FeS/SAM binding site; other site 211586010549 Domain of unknown function; Region: DUF331; pfam03889 211586010550 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211586010551 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 211586010552 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 211586010553 Putative modulator of DNA gyrase; Region: PmbA_TldD; cl19356 211586010554 hypothetical protein; Provisional; Region: PRK05255 211586010555 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 211586010556 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 211586010557 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 211586010558 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 211586010559 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 211586010560 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 211586010561 putative active site [active] 211586010562 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 211586010563 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 211586010564 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 211586010565 aromatic chitin/cellulose binding site residues [chemical binding]; other site 211586010566 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 211586010567 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 211586010568 ABC-2 type transporter; Region: ABC2_membrane; cl17235 211586010569 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 211586010570 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 211586010571 ABC-2 type transporter; Region: ABC2_membrane; cl17235 211586010572 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 211586010573 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 211586010574 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586010575 Outer membrane efflux protein; Region: OEP; pfam02321 211586010576 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 211586010577 Outer membrane efflux protein; Region: OEP; pfam02321 211586010578 Putative modulator of DNA gyrase; Region: PmbA_TldD; cl19356 211586010579 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 211586010580 putative active site [active] 211586010581 catalytic triad [active] 211586010582 dimer interface [polypeptide binding]; other site 211586010583 TIGR02099 family protein; Region: TIGR02099 211586010584 Protein of unknown function; Region: DUF3971; pfam13116 211586010585 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 211586010586 ribonuclease G; Provisional; Region: PRK11712 211586010587 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 211586010588 homodimer interface [polypeptide binding]; other site 211586010589 oligonucleotide binding site [chemical binding]; other site 211586010590 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 211586010591 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 211586010592 active site 211586010593 dimer interface [polypeptide binding]; other site 211586010594 rod shape-determining protein MreD; Region: MreD; cl01087 211586010595 rod shape-determining protein MreC; Provisional; Region: PRK13922 211586010596 rod shape-determining protein MreB; Provisional; Region: PRK13927 211586010597 MreB and similar proteins; Region: MreB_like; cd10225 211586010598 nucleotide binding site [chemical binding]; other site 211586010599 Mg binding site [ion binding]; other site 211586010600 putative protofilament interaction site [polypeptide binding]; other site 211586010601 RodZ interaction site [polypeptide binding]; other site 211586010602 VcfQ bacterial pilus biogenesis protein, lectin domain; Region: lectin_VcfQ; cd06900 211586010603 putative metal binding site [ion binding]; other site 211586010604 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 211586010605 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 211586010606 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 211586010607 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 211586010608 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 211586010609 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 211586010610 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 211586010611 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 211586010612 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 211586010613 putative major pilin subunit; Provisional; Region: PRK10574 211586010614 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 211586010615 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 211586010616 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 211586010617 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 211586010618 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 211586010619 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 211586010620 Walker A motif; other site 211586010621 ATP binding site [chemical binding]; other site 211586010622 Walker B motif; other site 211586010623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586010624 TPR motif; other site 211586010625 binding surface 211586010626 Tetratricopeptide repeat; Region: TPR_19; pfam14559 211586010627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586010628 binding surface 211586010629 TPR motif; other site 211586010630 TPR repeat; Region: TPR_11; pfam13414 211586010631 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 211586010632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586010633 Walker A motif; other site 211586010634 ATP binding site [chemical binding]; other site 211586010635 Walker B motif; other site 211586010636 arginine finger; other site 211586010637 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 211586010638 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 211586010639 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 211586010640 Type IV pilus assembly protein PilM; Region: PilM_2; pfam11104 211586010641 regulatory protein CsrD; Provisional; Region: PRK11059 211586010642 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 211586010643 nucleotidyl binding site; other site 211586010644 metal binding site [ion binding]; metal-binding site 211586010645 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586010646 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 211586010647 Malic enzyme, N-terminal domain; Region: malic; pfam00390 211586010648 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 211586010649 putative NAD(P) binding site [chemical binding]; other site 211586010650 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 211586010651 FimV N-terminal domain; Region: FimV_core; TIGR03505 211586010652 primosome assembly protein PriA; Validated; Region: PRK05580 211586010653 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211586010654 ATP binding site [chemical binding]; other site 211586010655 putative Mg++ binding site [ion binding]; other site 211586010656 helicase superfamily c-terminal domain; Region: HELICc; smart00490 211586010657 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 211586010658 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 211586010659 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 211586010660 active site 211586010661 HIGH motif; other site 211586010662 KMSK motif region; other site 211586010663 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 211586010664 tRNA binding surface [nucleotide binding]; other site 211586010665 anticodon binding site; other site 211586010666 cell division protein FtsN; Region: ftsN; TIGR02223 211586010667 Sporulation related domain; Region: SPOR; pfam05036 211586010668 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 211586010669 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 211586010670 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 211586010671 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 211586010672 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 211586010673 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 211586010674 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 211586010675 uridine phosphorylase; Provisional; Region: PRK11178 211586010676 Protein of unknown function (DUF465); Region: DUF465; cl01070 211586010677 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 211586010678 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586010679 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 211586010680 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 211586010681 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 211586010682 dimer interface [polypeptide binding]; other site 211586010683 active site 211586010684 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 211586010685 catalytic residues [active] 211586010686 substrate binding site [chemical binding]; other site 211586010687 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 211586010688 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 211586010689 Sel1-like repeats; Region: SEL1; smart00671 211586010690 Sel1-like repeats; Region: SEL1; smart00671 211586010691 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586010692 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586010693 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 211586010694 dimerization interface [polypeptide binding]; other site 211586010695 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 211586010696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 211586010697 NAD(P) binding site [chemical binding]; other site 211586010698 active site 211586010699 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 211586010700 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 211586010701 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 211586010702 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 211586010703 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 211586010704 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 211586010705 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586010706 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 211586010707 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211586010708 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211586010709 Walker A/P-loop; other site 211586010710 ATP binding site [chemical binding]; other site 211586010711 Q-loop/lid; other site 211586010712 ABC transporter signature motif; other site 211586010713 Walker B; other site 211586010714 D-loop; other site 211586010715 H-loop/switch region; other site 211586010716 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 211586010717 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211586010718 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 211586010719 Walker A/P-loop; other site 211586010720 ATP binding site [chemical binding]; other site 211586010721 Q-loop/lid; other site 211586010722 ABC transporter signature motif; other site 211586010723 Walker B; other site 211586010724 D-loop; other site 211586010725 H-loop/switch region; other site 211586010726 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 211586010727 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 211586010728 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 211586010729 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586010730 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010731 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010732 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010733 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010734 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010735 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010736 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 211586010737 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 211586010738 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010739 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010740 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 211586010741 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010742 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 211586010743 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010744 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010745 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 211586010746 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010747 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 211586010748 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 211586010749 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010750 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 211586010751 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010752 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010753 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010754 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010755 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010756 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010757 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010758 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010759 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010760 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010761 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010762 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010763 VCBS repeat; Region: VCBS_repeat; TIGR01965 211586010764 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 211586010765 Putative catalytic domain of Synechocystis sp. Sll1306 protein and other bacterial homologs; Region: CE4_Sll1306_like; cd10978 211586010766 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 211586010767 putative active site [active] 211586010768 putative catalytic site [active] 211586010769 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 211586010770 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 211586010771 FMN binding site [chemical binding]; other site 211586010772 active site 211586010773 substrate binding site [chemical binding]; other site 211586010774 catalytic residue [active] 211586010775 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586010776 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586010777 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 211586010778 putative effector binding pocket; other site 211586010779 dimerization interface [polypeptide binding]; other site 211586010780 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 211586010781 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 211586010782 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586010783 dimer interface [polypeptide binding]; other site 211586010784 phosphorylation site [posttranslational modification] 211586010785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586010786 ATP binding site [chemical binding]; other site 211586010787 Mg2+ binding site [ion binding]; other site 211586010788 G-X-G motif; other site 211586010789 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 211586010790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586010791 active site 211586010792 phosphorylation site [posttranslational modification] 211586010793 intermolecular recognition site; other site 211586010794 dimerization interface [polypeptide binding]; other site 211586010795 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 211586010796 DNA binding residues [nucleotide binding] 211586010797 dimerization interface [polypeptide binding]; other site 211586010798 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 211586010799 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 211586010800 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 211586010801 active site 211586010802 HslU subunit interaction site [polypeptide binding]; other site 211586010803 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 211586010804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586010805 Walker A motif; other site 211586010806 ATP binding site [chemical binding]; other site 211586010807 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 211586010808 Walker B motif; other site 211586010809 arginine finger; other site 211586010810 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 211586010811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 211586010812 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586010813 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586010814 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 211586010815 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 211586010816 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 211586010817 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 211586010818 NADP binding site [chemical binding]; other site 211586010819 homodimer interface [polypeptide binding]; other site 211586010820 active site 211586010821 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 211586010822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586010823 active site 211586010824 phosphorylation site [posttranslational modification] 211586010825 intermolecular recognition site; other site 211586010826 dimerization interface [polypeptide binding]; other site 211586010827 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 211586010828 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 211586010829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586010830 ATP binding site [chemical binding]; other site 211586010831 Mg2+ binding site [ion binding]; other site 211586010832 G-X-G motif; other site 211586010833 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 211586010834 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 211586010835 NADP binding site [chemical binding]; other site 211586010836 active site 211586010837 putative substrate binding site [chemical binding]; other site 211586010838 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 211586010839 putative active site [active] 211586010840 putative metal binding site [ion binding]; other site 211586010841 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 211586010842 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 211586010843 Salmonella-Shigella invasin protein C (IpaC_SipC); Region: IpaC_SipC; cl10712 211586010844 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 211586010845 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 211586010846 DXD motif; other site 211586010847 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 211586010848 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 211586010849 active site 211586010850 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 211586010851 Transposase; Region: HTH_Tnp_1; pfam01527 211586010852 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586010853 putative transposase OrfB; Reviewed; Region: PHA02517 211586010854 HTH-like domain; Region: HTH_21; pfam13276 211586010855 Integrase core domain; Region: rve; pfam00665 211586010856 Integrase core domain; Region: rve_2; pfam13333 211586010857 Domain of unknown function (DUF386); Region: DUF386; cl01047 211586010858 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 211586010859 DHH family; Region: DHH; pfam01368 211586010860 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 211586010861 DHHA2 domain; Region: DHHA2; pfam02833 211586010862 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 211586010863 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 211586010864 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 211586010865 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 211586010866 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 211586010867 active site 211586010868 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 211586010869 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 211586010870 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 211586010871 putative active site [active] 211586010872 putative metal binding site [ion binding]; other site 211586010873 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 211586010874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586010875 S-adenosylmethionine binding site [chemical binding]; other site 211586010876 SCP-2 sterol transfer family; Region: SCP2; cl01225 211586010877 ABC1 family; Region: ABC1; cl17513 211586010878 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 211586010879 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 211586010880 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 211586010881 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 211586010882 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 211586010883 active site 211586010884 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 211586010885 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 211586010886 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586010887 metal binding site [ion binding]; metal-binding site 211586010888 active site 211586010889 I-site; other site 211586010890 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 211586010891 dimer interface [polypeptide binding]; other site 211586010892 allosteric magnesium binding site [ion binding]; other site 211586010893 active site 211586010894 aspartate-rich active site metal binding site; other site 211586010895 Schiff base residues; other site 211586010896 preprotein translocase subunit SecA; Reviewed; Region: PRK13107 211586010897 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 211586010898 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 211586010899 SEC-C motif; Region: SEC-C; pfam02810 211586010900 HemX; Region: HemX; cl19375 211586010901 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 211586010902 Peptidase family M23; Region: Peptidase_M23; pfam01551 211586010903 Protein of unknown function (DUF721); Region: DUF721; cl02324 211586010904 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 211586010905 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 211586010906 cell division protein FtsZ; Validated; Region: PRK09330 211586010907 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 211586010908 nucleotide binding site [chemical binding]; other site 211586010909 SulA interaction site; other site 211586010910 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 211586010911 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 211586010912 nucleotide binding site [chemical binding]; other site 211586010913 Cell division protein FtsA; Region: FtsA; pfam14450 211586010914 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 211586010915 Cell division protein FtsQ; Region: FtsQ; pfam03799 211586010916 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 211586010917 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 211586010918 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 211586010919 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 211586010920 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 211586010921 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 211586010922 active site 211586010923 homodimer interface [polypeptide binding]; other site 211586010924 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 211586010925 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 211586010926 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 211586010927 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 211586010928 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 211586010929 Mg++ binding site [ion binding]; other site 211586010930 putative catalytic motif [active] 211586010931 putative substrate binding site [chemical binding]; other site 211586010932 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 211586010933 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 211586010934 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 211586010935 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 211586010936 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 211586010937 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 211586010938 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 211586010939 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 211586010940 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 211586010941 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 211586010942 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 211586010943 Cell division protein FtsL; Region: FtsL; pfam04999 211586010944 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 211586010945 cell division protein MraZ; Reviewed; Region: PRK00326 211586010946 MraZ protein; Region: MraZ; pfam02381 211586010947 MraZ protein; Region: MraZ; pfam02381 211586010948 glycerol kinase; Provisional; Region: glpK; PRK00047 211586010949 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 211586010950 N- and C-terminal domain interface [polypeptide binding]; other site 211586010951 active site 211586010952 MgATP binding site [chemical binding]; other site 211586010953 catalytic site [active] 211586010954 metal binding site [ion binding]; metal-binding site 211586010955 glycerol binding site [chemical binding]; other site 211586010956 homotetramer interface [polypeptide binding]; other site 211586010957 homodimer interface [polypeptide binding]; other site 211586010958 FBP binding site [chemical binding]; other site 211586010959 protein IIAGlc interface [polypeptide binding]; other site 211586010960 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 211586010961 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 211586010962 substrate binding site [chemical binding]; other site 211586010963 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 211586010964 substrate binding site [chemical binding]; other site 211586010965 ligand binding site [chemical binding]; other site 211586010966 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 211586010967 2-isopropylmalate synthase; Validated; Region: PRK00915 211586010968 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 211586010969 active site 211586010970 catalytic residues [active] 211586010971 metal binding site [ion binding]; metal-binding site 211586010972 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 211586010973 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586010974 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 211586010975 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211586010976 ATP binding site [chemical binding]; other site 211586010977 putative Mg++ binding site [ion binding]; other site 211586010978 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586010979 nucleotide binding region [chemical binding]; other site 211586010980 ATP-binding site [chemical binding]; other site 211586010981 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 211586010982 HRDC domain; Region: HRDC; pfam00570 211586010983 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 211586010984 CoenzymeA binding site [chemical binding]; other site 211586010985 subunit interaction site [polypeptide binding]; other site 211586010986 PHB binding site; other site 211586010987 Predicted permeases [General function prediction only]; Region: RarD; COG2962 211586010988 EamA-like transporter family; Region: EamA; cl17759 211586010989 Bacterial PH domain; Region: bPH_4; cl19751 211586010990 N-acetylglutamate synthase; Validated; Region: PRK05279 211586010991 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 211586010992 putative feedback inhibition sensing region; other site 211586010993 putative nucleotide binding site [chemical binding]; other site 211586010994 putative substrate binding site [chemical binding]; other site 211586010995 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586010996 Coenzyme A binding pocket [chemical binding]; other site 211586010997 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 211586010998 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 211586010999 hypothetical protein; Reviewed; Region: PRK00024 211586011000 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 211586011001 MPN+ (JAMM) motif; other site 211586011002 Zinc-binding site [ion binding]; other site 211586011003 Flavoprotein; Region: Flavoprotein; cl19190 211586011004 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 211586011005 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 211586011006 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 211586011007 trimer interface [polypeptide binding]; other site 211586011008 active site 211586011009 division inhibitor protein; Provisional; Region: slmA; PRK09480 211586011010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211586011011 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 211586011012 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 211586011013 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 211586011014 active site 211586011015 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211586011016 active site 211586011017 ribonuclease PH; Reviewed; Region: rph; PRK00173 211586011018 Ribonuclease PH; Region: RNase_PH_bact; cd11362 211586011019 hexamer interface [polypeptide binding]; other site 211586011020 active site 211586011021 hypothetical protein; Provisional; Region: PRK11820 211586011022 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 211586011023 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 211586011024 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586011025 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586011026 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 211586011027 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 211586011028 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 211586011029 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 211586011030 HsdM N-terminal domain; Region: HsdM_N; pfam12161 211586011031 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 211586011032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586011033 S-adenosylmethionine binding site [chemical binding]; other site 211586011034 Fic family protein [Function unknown]; Region: COG3177 211586011035 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 211586011036 Fic/DOC family; Region: Fic; pfam02661 211586011037 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 211586011038 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 211586011039 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 211586011040 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211586011041 ATP binding site [chemical binding]; other site 211586011042 putative Mg++ binding site [ion binding]; other site 211586011043 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586011044 nucleotide binding region [chemical binding]; other site 211586011045 ATP-binding site [chemical binding]; other site 211586011046 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 211586011047 Transposase; Region: HTH_Tnp_1; pfam01527 211586011048 Winged helix-turn helix; Region: HTH_29; pfam13551 211586011049 HTH-like domain; Region: HTH_21; pfam13276 211586011050 Integrase core domain; Region: rve; pfam00665 211586011051 Integrase core domain; Region: rve_3; pfam13683 211586011052 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 211586011053 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 211586011054 Transposase; Region: HTH_Tnp_1; pfam01527 211586011055 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586011056 putative transposase OrfB; Reviewed; Region: PHA02517 211586011057 HTH-like domain; Region: HTH_21; pfam13276 211586011058 Integrase core domain; Region: rve; pfam00665 211586011059 Integrase core domain; Region: rve_2; pfam13333 211586011060 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 211586011061 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 211586011062 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 211586011063 TrkA-N domain; Region: TrkA_N; pfam02254 211586011064 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 211586011065 Cation transport protein; Region: TrkH; cl17365 211586011066 ApbE family; Region: ApbE; pfam02424 211586011067 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586011068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586011069 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 211586011070 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 211586011071 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 211586011072 ligand binding site [chemical binding]; other site 211586011073 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 211586011074 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 211586011075 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14253 211586011076 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 211586011077 Walker A/P-loop; other site 211586011078 ATP binding site [chemical binding]; other site 211586011079 Q-loop/lid; other site 211586011080 ABC transporter signature motif; other site 211586011081 Walker B; other site 211586011082 D-loop; other site 211586011083 H-loop/switch region; other site 211586011084 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 211586011085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211586011086 dimer interface [polypeptide binding]; other site 211586011087 conserved gate region; other site 211586011088 putative PBP binding loops; other site 211586011089 ABC-ATPase subunit interface; other site 211586011090 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 211586011091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211586011092 dimer interface [polypeptide binding]; other site 211586011093 conserved gate region; other site 211586011094 putative PBP binding loops; other site 211586011095 ABC-ATPase subunit interface; other site 211586011096 phosphate binding protein; Region: ptsS_2; TIGR02136 211586011097 Transposase; Region: HTH_Tnp_1; pfam01527 211586011098 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586011099 putative transposase OrfB; Reviewed; Region: PHA02517 211586011100 HTH-like domain; Region: HTH_21; pfam13276 211586011101 Integrase core domain; Region: rve; pfam00665 211586011102 Integrase core domain; Region: rve_2; pfam13333 211586011103 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 211586011104 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 211586011105 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 211586011106 Nucleoside recognition; Region: Gate; pfam07670 211586011107 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 211586011108 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 211586011109 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 211586011110 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 211586011111 ligand binding site [chemical binding]; other site 211586011112 flexible hinge region; other site 211586011113 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 211586011114 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 211586011115 trimer interface [polypeptide binding]; other site 211586011116 active site 211586011117 substrate binding site [chemical binding]; other site 211586011118 CoA binding site [chemical binding]; other site 211586011119 Transposase; Region: HTH_Tnp_1; pfam01527 211586011120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586011121 putative transposase OrfB; Reviewed; Region: PHA02517 211586011122 HTH-like domain; Region: HTH_21; pfam13276 211586011123 Integrase core domain; Region: rve; pfam00665 211586011124 Integrase core domain; Region: rve_2; pfam13333 211586011125 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 211586011126 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 211586011127 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 211586011128 Divergent AAA domain; Region: AAA_4; pfam04326 211586011129 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 211586011130 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 211586011131 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 211586011132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 211586011133 motif II; other site 211586011134 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 211586011135 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 211586011136 active site 211586011137 DNA binding site [nucleotide binding] 211586011138 Int/Topo IB signature motif; other site 211586011139 Protein of unknown function, DUF484; Region: DUF484; cl17449 211586011140 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 211586011141 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 211586011142 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 211586011143 diaminopimelate decarboxylase; Region: lysA; TIGR01048 211586011144 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 211586011145 active site 211586011146 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 211586011147 substrate binding site [chemical binding]; other site 211586011148 catalytic residues [active] 211586011149 dimer interface [polypeptide binding]; other site 211586011150 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 211586011151 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 211586011152 putative iron binding site [ion binding]; other site 211586011153 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 211586011154 adenylate cyclase; Provisional; Region: cyaA; PRK09450 211586011155 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 211586011156 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 211586011157 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 211586011158 domain interfaces; other site 211586011159 active site 211586011160 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 211586011161 active site 211586011162 HemX; Region: HemX; cl19375 211586011163 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 211586011164 HemY protein N-terminus; Region: HemY_N; pfam07219 211586011165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 211586011166 binding surface 211586011167 TPR motif; other site 211586011168 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 211586011169 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 211586011170 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 211586011171 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 211586011172 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 211586011173 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 211586011174 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 211586011175 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211586011176 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 211586011177 Walker A/P-loop; other site 211586011178 ATP binding site [chemical binding]; other site 211586011179 Q-loop/lid; other site 211586011180 ABC transporter signature motif; other site 211586011181 Walker B; other site 211586011182 D-loop; other site 211586011183 H-loop/switch region; other site 211586011184 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 211586011185 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 211586011186 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586011187 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 211586011188 Outer membrane efflux protein; Region: OEP; pfam02321 211586011189 Outer membrane efflux protein; Region: OEP; pfam02321 211586011190 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 211586011191 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 211586011192 ligand binding site [chemical binding]; other site 211586011193 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: Peptidase_C93; cl17596 211586011194 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586011195 dimerization interface [polypeptide binding]; other site 211586011196 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586011197 metal binding site [ion binding]; metal-binding site 211586011198 active site 211586011199 I-site; other site 211586011200 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586011201 GAF domain; Region: GAF_2; pfam13185 211586011202 GAF domain; Region: GAF_2; pfam13185 211586011203 diguanylate cyclase; Provisional; Region: PRK09894 211586011204 Orbivirus outer capsid protein VP5; Region: Orbi_VP5; pfam00901 211586011205 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586011206 metal binding site [ion binding]; metal-binding site 211586011207 active site 211586011208 I-site; other site 211586011209 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586011210 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 211586011211 Part of AAA domain; Region: AAA_19; pfam13245 211586011212 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 211586011213 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 211586011214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211586011215 sequence-specific DNA binding site [nucleotide binding]; other site 211586011216 salt bridge; other site 211586011217 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 211586011218 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 211586011219 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586011220 multidrug efflux protein; Reviewed; Region: PRK09579 211586011221 MMPL family; Region: MMPL; cl14618 211586011222 MMPL family; Region: MMPL; cl14618 211586011223 Membrane fusogenic activity; Region: BMFP; cl01115 211586011224 Winged helix DNA-binding domain; Region: HTH_42; pfam06224 211586011225 inner membrane protein; Provisional; Region: PRK11715 211586011226 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 211586011227 active site 211586011228 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 211586011229 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 211586011230 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 211586011231 putative DNA binding site [nucleotide binding]; other site 211586011232 putative Zn2+ binding site [ion binding]; other site 211586011233 AsnC family; Region: AsnC_trans_reg; pfam01037 211586011234 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 211586011235 Na2 binding site [ion binding]; other site 211586011236 putative substrate binding site 1 [chemical binding]; other site 211586011237 Na binding site 1 [ion binding]; other site 211586011238 putative substrate binding site 2 [chemical binding]; other site 211586011239 Tim44-like domain; Region: Tim44; pfam04280 211586011240 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 211586011241 homodimer interface [polypeptide binding]; other site 211586011242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586011243 catalytic residue [active] 211586011244 threonine dehydratase; Reviewed; Region: PRK09224 211586011245 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 211586011246 tetramer interface [polypeptide binding]; other site 211586011247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586011248 catalytic residue [active] 211586011249 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 211586011250 putative Ile/Val binding site [chemical binding]; other site 211586011251 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 211586011252 putative Ile/Val binding site [chemical binding]; other site 211586011253 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 211586011254 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 211586011255 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 211586011256 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 211586011257 PYR/PP interface [polypeptide binding]; other site 211586011258 dimer interface [polypeptide binding]; other site 211586011259 TPP binding site [chemical binding]; other site 211586011260 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 211586011261 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 211586011262 TPP-binding site [chemical binding]; other site 211586011263 dimer interface [polypeptide binding]; other site 211586011264 ketol-acid reductoisomerase; Validated; Region: PRK05225 211586011265 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 211586011266 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 211586011267 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586011268 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 211586011269 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 211586011270 putative dimerization interface [polypeptide binding]; other site 211586011271 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 211586011272 Domain of unknown function DUF21; Region: DUF21; pfam01595 211586011273 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 211586011274 Transporter associated domain; Region: CorC_HlyC; smart01091 211586011275 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 211586011276 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 211586011277 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 211586011278 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 211586011279 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 211586011280 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 211586011281 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 211586011282 putative [Fe4-S4] binding site [ion binding]; other site 211586011283 putative molybdopterin cofactor binding site [chemical binding]; other site 211586011284 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 211586011285 putative molybdopterin cofactor binding site; other site 211586011286 decaheme-associated outer membrane protein, MtrB/PioB family; Region: OMP_MtrB_PioB; TIGR03509 211586011287 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 211586011288 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 211586011289 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 211586011290 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 211586011291 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 211586011292 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 211586011293 Y-family of DNA polymerases; Region: PolY; cl12025 211586011294 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 211586011295 generic binding surface II; other site 211586011296 ssDNA binding site; other site 211586011297 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 211586011298 ATP binding site [chemical binding]; other site 211586011299 putative Mg++ binding site [ion binding]; other site 211586011300 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 211586011301 nucleotide binding region [chemical binding]; other site 211586011302 ATP-binding site [chemical binding]; other site 211586011303 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 211586011304 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 211586011305 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 211586011306 putative acyl-acceptor binding pocket; other site 211586011307 Phosphopantetheine attachment site; Region: PP-binding; cl09936 211586011308 acyl carrier protein; Provisional; Region: PRK05350 211586011309 Predicted membrane protein [Function unknown]; Region: COG4648 211586011310 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 211586011311 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 211586011312 acyl-activating enzyme (AAE) consensus motif; other site 211586011313 AMP binding site [chemical binding]; other site 211586011314 active site 211586011315 CoA binding site [chemical binding]; other site 211586011316 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 211586011317 active site 2 [active] 211586011318 active site 1 [active] 211586011319 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 211586011320 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 211586011321 Ligand binding site; other site 211586011322 Putative Catalytic site; other site 211586011323 DXD motif; other site 211586011324 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 211586011325 putative acyl-acceptor binding pocket; other site 211586011326 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 211586011327 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 211586011328 active sites [active] 211586011329 tetramer interface [polypeptide binding]; other site 211586011330 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 211586011331 active site 211586011332 Predicted exporter [General function prediction only]; Region: COG4258 211586011333 MMPL family; Region: MMPL; cl14618 211586011334 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 211586011335 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 211586011336 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 211586011337 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 211586011338 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 211586011339 dimer interface [polypeptide binding]; other site 211586011340 active site 211586011341 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 211586011342 putative active site 1 [active] 211586011343 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 211586011344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 211586011345 NAD(P) binding site [chemical binding]; other site 211586011346 active site 211586011347 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 211586011348 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 211586011349 dimer interface [polypeptide binding]; other site 211586011350 active site 211586011351 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 211586011352 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 211586011353 metal ion-dependent adhesion site (MIDAS); other site 211586011354 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586011355 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586011356 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211586011357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586011358 active site 211586011359 phosphorylation site [posttranslational modification] 211586011360 intermolecular recognition site; other site 211586011361 dimerization interface [polypeptide binding]; other site 211586011362 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211586011363 DNA binding site [nucleotide binding] 211586011364 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 211586011365 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 211586011366 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586011367 Coenzyme A binding pocket [chemical binding]; other site 211586011368 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 211586011369 active site residue [active] 211586011370 azoreductase; Reviewed; Region: PRK00170 211586011371 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 211586011372 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 211586011373 putative active site [active] 211586011374 dimerization interface [polypeptide binding]; other site 211586011375 putative tRNAtyr binding site [nucleotide binding]; other site 211586011376 Putative lysophospholipase; Region: Hydrolase_4; cl19140 211586011377 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 211586011378 hypothetical protein; Reviewed; Region: PRK01637 211586011379 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 211586011380 4Fe-4S binding domain; Region: Fer4_5; pfam12801 211586011381 4Fe-4S binding domain; Region: Fer4_5; pfam12801 211586011382 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 211586011383 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 211586011384 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 211586011385 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 211586011386 dimer interface [polypeptide binding]; other site 211586011387 active site 211586011388 heme binding site [chemical binding]; other site 211586011389 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 211586011390 SnoaL-like domain; Region: SnoaL_3; pfam13474 211586011391 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586011392 metal binding site [ion binding]; metal-binding site 211586011393 active site 211586011394 I-site; other site 211586011395 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 211586011396 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 211586011397 G1 box; other site 211586011398 putative GEF interaction site [polypeptide binding]; other site 211586011399 GTP/Mg2+ binding site [chemical binding]; other site 211586011400 Switch I region; other site 211586011401 G2 box; other site 211586011402 G3 box; other site 211586011403 Switch II region; other site 211586011404 G4 box; other site 211586011405 G5 box; other site 211586011406 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 211586011407 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 211586011408 glutamine synthetase; Provisional; Region: glnA; PRK09469 211586011409 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 211586011410 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 211586011411 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 211586011412 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 211586011413 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 211586011414 catalytic residue [active] 211586011415 Domain of unknown function (DUF1864); Region: DUF1864; pfam08933 211586011416 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 211586011417 CHAP domain; Region: CHAP; pfam05257 211586011418 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 211586011419 Peptidase family M23; Region: Peptidase_M23; pfam01551 211586011420 Protein of unknown function (DUF2986); Region: DUF2986; pfam11661 211586011421 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 211586011422 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 211586011423 N-terminal plug; other site 211586011424 ligand-binding site [chemical binding]; other site 211586011425 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586011426 metal binding site [ion binding]; metal-binding site 211586011427 active site 211586011428 I-site; other site 211586011429 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 211586011430 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 211586011431 active site 211586011432 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211586011433 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586011434 dimerization interface [polypeptide binding]; other site 211586011435 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586011436 dimer interface [polypeptide binding]; other site 211586011437 phosphorylation site [posttranslational modification] 211586011438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586011439 ATP binding site [chemical binding]; other site 211586011440 Mg2+ binding site [ion binding]; other site 211586011441 G-X-G motif; other site 211586011442 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211586011443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586011444 active site 211586011445 phosphorylation site [posttranslational modification] 211586011446 intermolecular recognition site; other site 211586011447 dimerization interface [polypeptide binding]; other site 211586011448 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211586011449 DNA binding site [nucleotide binding] 211586011450 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 211586011451 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586011452 putative fimbrial protein TcfA; Provisional; Region: PRK15308 211586011453 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586011454 Outer membrane usher protein; Region: Usher; pfam00577 211586011455 Transposase; Region: HTH_Tnp_1; pfam01527 211586011456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586011457 putative transposase OrfB; Reviewed; Region: PHA02517 211586011458 HTH-like domain; Region: HTH_21; pfam13276 211586011459 Integrase core domain; Region: rve; pfam00665 211586011460 Integrase core domain; Region: rve_2; pfam13333 211586011461 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 211586011462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586011463 active site 211586011464 phosphorylation site [posttranslational modification] 211586011465 intermolecular recognition site; other site 211586011466 dimerization interface [polypeptide binding]; other site 211586011467 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 211586011468 DNA binding residues [nucleotide binding] 211586011469 dimerization interface [polypeptide binding]; other site 211586011470 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211586011471 substrate binding pocket [chemical binding]; other site 211586011472 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 211586011473 membrane-bound complex binding site; other site 211586011474 hinge residues; other site 211586011475 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211586011476 substrate binding pocket [chemical binding]; other site 211586011477 membrane-bound complex binding site; other site 211586011478 hinge residues; other site 211586011479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586011480 dimer interface [polypeptide binding]; other site 211586011481 phosphorylation site [posttranslational modification] 211586011482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586011483 ATP binding site [chemical binding]; other site 211586011484 Mg2+ binding site [ion binding]; other site 211586011485 G-X-G motif; other site 211586011486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586011487 active site 211586011488 phosphorylation site [posttranslational modification] 211586011489 intermolecular recognition site; other site 211586011490 dimerization interface [polypeptide binding]; other site 211586011491 Hpt domain; Region: Hpt; pfam01627 211586011492 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 211586011493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211586011494 Walker A/P-loop; other site 211586011495 ATP binding site [chemical binding]; other site 211586011496 Q-loop/lid; other site 211586011497 ABC transporter signature motif; other site 211586011498 Walker B; other site 211586011499 D-loop; other site 211586011500 H-loop/switch region; other site 211586011501 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 211586011502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211586011503 dimer interface [polypeptide binding]; other site 211586011504 conserved gate region; other site 211586011505 putative PBP binding loops; other site 211586011506 ABC-ATPase subunit interface; other site 211586011507 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 211586011508 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 211586011509 MoaE homodimer interface [polypeptide binding]; other site 211586011510 MoaD interaction [polypeptide binding]; other site 211586011511 active site residues [active] 211586011512 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 211586011513 MoaE interaction surface [polypeptide binding]; other site 211586011514 MoeB interaction surface [polypeptide binding]; other site 211586011515 thiocarboxylated glycine; other site 211586011516 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 211586011517 trimer interface [polypeptide binding]; other site 211586011518 dimer interface [polypeptide binding]; other site 211586011519 putative active site [active] 211586011520 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 211586011521 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211586011522 FeS/SAM binding site; other site 211586011523 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 211586011524 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 211586011525 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 211586011526 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 211586011527 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 211586011528 Cache domain; Region: Cache_1; pfam02743 211586011529 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586011530 dimerization interface [polypeptide binding]; other site 211586011531 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 211586011532 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 211586011533 dimer interface [polypeptide binding]; other site 211586011534 putative CheW interface [polypeptide binding]; other site 211586011535 Tic20-like protein; Region: Tic20; pfam09685 211586011536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 211586011537 MOSC domain; Region: MOSC; pfam03473 211586011538 3-alpha domain; Region: 3-alpha; pfam03475 211586011539 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586011540 metal binding site [ion binding]; metal-binding site 211586011541 active site 211586011542 I-site; other site 211586011543 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 211586011544 substrate binding site [chemical binding]; other site 211586011545 ATP binding site [chemical binding]; other site 211586011546 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 211586011547 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 211586011548 DinB superfamily; Region: DinB_2; pfam12867 211586011549 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 211586011550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586011551 S-adenosylmethionine binding site [chemical binding]; other site 211586011552 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 211586011553 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 211586011554 dimer interface [polypeptide binding]; other site 211586011555 putative CheW interface [polypeptide binding]; other site 211586011556 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 211586011557 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 211586011558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211586011559 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 211586011560 dimer interface [polypeptide binding]; other site 211586011561 active site 211586011562 metal binding site [ion binding]; metal-binding site 211586011563 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 211586011564 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 211586011565 PAS domain; Region: PAS_8; pfam13188 211586011566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586011567 dimer interface [polypeptide binding]; other site 211586011568 phosphorylation site [posttranslational modification] 211586011569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586011570 ATP binding site [chemical binding]; other site 211586011571 Mg2+ binding site [ion binding]; other site 211586011572 G-X-G motif; other site 211586011573 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 211586011574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586011575 active site 211586011576 phosphorylation site [posttranslational modification] 211586011577 intermolecular recognition site; other site 211586011578 dimerization interface [polypeptide binding]; other site 211586011579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586011580 Walker A motif; other site 211586011581 ATP binding site [chemical binding]; other site 211586011582 Walker B motif; other site 211586011583 arginine finger; other site 211586011584 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 211586011585 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 211586011586 Cation efflux family; Region: Cation_efflux; cl00316 211586011587 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 211586011588 dimer interface [polypeptide binding]; other site 211586011589 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 211586011590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586011591 active site 211586011592 phosphorylation site [posttranslational modification] 211586011593 intermolecular recognition site; other site 211586011594 dimerization interface [polypeptide binding]; other site 211586011595 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211586011596 DNA binding site [nucleotide binding] 211586011597 two-component sensor protein; Provisional; Region: cpxA; PRK09470 211586011598 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586011599 dimerization interface [polypeptide binding]; other site 211586011600 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586011601 dimer interface [polypeptide binding]; other site 211586011602 phosphorylation site [posttranslational modification] 211586011603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586011604 ATP binding site [chemical binding]; other site 211586011605 Mg2+ binding site [ion binding]; other site 211586011606 G-X-G motif; other site 211586011607 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 211586011608 GAF domain; Region: GAF; pfam01590 211586011609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586011610 Walker A motif; other site 211586011611 ATP binding site [chemical binding]; other site 211586011612 Walker B motif; other site 211586011613 arginine finger; other site 211586011614 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 211586011615 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 211586011616 NAD(P) binding site [chemical binding]; other site 211586011617 catalytic residues [active] 211586011618 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 211586011619 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 211586011620 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 211586011621 Dihaem cytochrome c; Region: DHC; pfam09626 211586011622 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 211586011623 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211586011624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586011625 active site 211586011626 phosphorylation site [posttranslational modification] 211586011627 intermolecular recognition site; other site 211586011628 dimerization interface [polypeptide binding]; other site 211586011629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211586011630 DNA binding site [nucleotide binding] 211586011631 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211586011632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586011633 ATP binding site [chemical binding]; other site 211586011634 G-X-G motif; other site 211586011635 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 211586011636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586011637 Coenzyme A binding pocket [chemical binding]; other site 211586011638 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 211586011639 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586011640 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586011641 Helix-turn-helix domain; Region: HTH_17; pfam12728 211586011642 PBP superfamily domain; Region: PBP_like; pfam12727 211586011643 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 211586011644 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 211586011645 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 211586011646 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 211586011647 Ferredoxin [Energy production and conversion]; Region: COG1146 211586011648 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 211586011649 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 211586011650 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 211586011651 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 211586011652 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 211586011653 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 211586011654 molybdopterin cofactor binding site; other site 211586011655 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 211586011656 molybdopterin cofactor binding site; other site 211586011657 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 211586011658 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 211586011659 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 211586011660 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 211586011661 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 211586011662 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 211586011663 [4Fe-4S] binding site [ion binding]; other site 211586011664 molybdopterin cofactor binding site; other site 211586011665 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 211586011666 molybdopterin cofactor binding site; other site 211586011667 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 211586011668 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 211586011669 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 211586011670 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 211586011671 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 211586011672 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 211586011673 coproporphyrinogen III oxidase; Provisional; Region: PRK08629 211586011674 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211586011675 FeS/SAM binding site; other site 211586011676 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 211586011677 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 211586011678 enterobactin receptor protein; Provisional; Region: PRK13483 211586011679 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 211586011680 N-terminal plug; other site 211586011681 ligand-binding site [chemical binding]; other site 211586011682 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586011683 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586011684 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 211586011685 putative effector binding pocket; other site 211586011686 dimerization interface [polypeptide binding]; other site 211586011687 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 211586011688 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 211586011689 active site 211586011690 nucleophile elbow; other site 211586011691 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 211586011692 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586011693 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 211586011694 substrate binding pocket [chemical binding]; other site 211586011695 dimerization interface [polypeptide binding]; other site 211586011696 EamA-like transporter family; Region: EamA; pfam00892 211586011697 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 211586011698 EamA-like transporter family; Region: EamA; pfam00892 211586011699 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211586011700 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 211586011701 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 211586011702 Homeodomain-like domain; Region: HTH_23; pfam13384 211586011703 Winged helix-turn helix; Region: HTH_33; pfam13592 211586011704 DDE superfamily endonuclease; Region: DDE_3; pfam13358 211586011705 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 211586011706 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 211586011707 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 211586011708 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 211586011709 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 211586011710 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 211586011711 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 211586011712 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 211586011713 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 211586011714 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 211586011715 Subtilase family; Region: Peptidase_S8; pfam00082 211586011716 active site 211586011717 catalytic triad [active] 211586011718 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 211586011719 PA/protease or protease-like domain interface [polypeptide binding]; other site 211586011720 GlyGly-CTERM domain; Region: GlyGly_CTERM; TIGR03501 211586011721 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586011722 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586011723 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 211586011724 dimerization interface [polypeptide binding]; other site 211586011725 Putative esterase; Region: Esterase; pfam00756 211586011726 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 211586011727 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586011728 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586011729 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 211586011730 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 211586011731 Transposase; Region: DEDD_Tnp_IS110; pfam01548 211586011732 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 211586011733 Methyltransferase domain; Region: Methyltransf_23; pfam13489 211586011734 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 211586011735 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586011736 PAS domain; Region: PAS_9; pfam13426 211586011737 putative active site [active] 211586011738 heme pocket [chemical binding]; other site 211586011739 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586011740 metal binding site [ion binding]; metal-binding site 211586011741 active site 211586011742 I-site; other site 211586011743 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586011744 DTW domain; Region: DTW; cl01221 211586011745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 211586011746 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 211586011747 putative substrate translocation pore; other site 211586011748 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 211586011749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586011750 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 211586011751 substrate binding pocket [chemical binding]; other site 211586011752 dimerization interface [polypeptide binding]; other site 211586011753 Cache domain; Region: Cache_1; pfam02743 211586011754 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586011755 dimerization interface [polypeptide binding]; other site 211586011756 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 211586011757 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 211586011758 dimer interface [polypeptide binding]; other site 211586011759 putative CheW interface [polypeptide binding]; other site 211586011760 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 211586011761 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 211586011762 Sel1-like repeats; Region: SEL1; smart00671 211586011763 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 211586011764 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 211586011765 putative metal binding site [ion binding]; other site 211586011766 HDOD domain; Region: HDOD; pfam08668 211586011767 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 211586011768 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 211586011769 putative transporter; Provisional; Region: PRK11021 211586011770 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 211586011771 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 211586011772 dimerization interface [polypeptide binding]; other site 211586011773 putative Zn2+ binding site [ion binding]; other site 211586011774 putative DNA binding site [nucleotide binding]; other site 211586011775 AsnC family; Region: AsnC_trans_reg; pfam01037 211586011776 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 211586011777 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586011778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586011779 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 211586011780 dimerization interface [polypeptide binding]; other site 211586011781 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 211586011782 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 211586011783 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 211586011784 dimer interface [polypeptide binding]; other site 211586011785 tetramer interface [polypeptide binding]; other site 211586011786 PYR/PP interface [polypeptide binding]; other site 211586011787 TPP binding site [chemical binding]; other site 211586011788 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 211586011789 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 211586011790 TPP-binding site; other site 211586011791 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 211586011792 Putative lysophospholipase; Region: Hydrolase_4; cl19140 211586011793 O-succinylbenzoate synthase; Provisional; Region: PRK05105 211586011794 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 211586011795 active site 211586011796 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 211586011797 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 211586011798 acyl-activating enzyme (AAE) consensus motif; other site 211586011799 putative AMP binding site [chemical binding]; other site 211586011800 putative active site [active] 211586011801 putative CoA binding site [chemical binding]; other site 211586011802 Homeodomain-like domain; Region: HTH_23; pfam13384 211586011803 Winged helix-turn helix; Region: HTH_29; pfam13551 211586011804 DDE superfamily endonuclease; Region: DDE_3; pfam13358 211586011805 Fimbrial protein; Region: Fimbrial; cl01416 211586011806 Transposase; Region: HTH_Tnp_1; pfam01527 211586011807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586011808 putative transposase OrfB; Reviewed; Region: PHA02517 211586011809 HTH-like domain; Region: HTH_21; pfam13276 211586011810 Integrase core domain; Region: rve; pfam00665 211586011811 Integrase core domain; Region: rve_2; pfam13333 211586011812 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586011813 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586011814 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 211586011815 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 211586011816 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 211586011817 DNA binding residues [nucleotide binding] 211586011818 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 211586011819 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 211586011820 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 211586011821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 211586011822 Walker A/P-loop; other site 211586011823 ATP binding site [chemical binding]; other site 211586011824 Q-loop/lid; other site 211586011825 ABC transporter signature motif; other site 211586011826 Walker B; other site 211586011827 D-loop; other site 211586011828 H-loop/switch region; other site 211586011829 CheD chemotactic sensory transduction; Region: CheD; cl00810 211586011830 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 211586011831 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 211586011832 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 211586011833 P loop; other site 211586011834 GTP binding site [chemical binding]; other site 211586011835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586011836 S-adenosylmethionine binding site [chemical binding]; other site 211586011837 Protein of unknown function (DUF1145); Region: DUF1145; pfam06611 211586011838 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 211586011839 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 211586011840 conserved cys residue [active] 211586011841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 211586011842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 211586011843 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 211586011844 catalytic triad [active] 211586011845 conserved cis-peptide bond; other site 211586011846 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 211586011847 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 211586011848 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 211586011849 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586011850 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 211586011851 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 211586011852 B1 nucleotide binding pocket [chemical binding]; other site 211586011853 B2 nucleotide binding pocket [chemical binding]; other site 211586011854 CAS motifs; other site 211586011855 active site 211586011856 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 211586011857 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 211586011858 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 211586011859 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 211586011860 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 211586011861 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 211586011862 putative acyl-acceptor binding pocket; other site 211586011863 LexA repressor; Validated; Region: PRK00215 211586011864 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 211586011865 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 211586011866 Catalytic site [active] 211586011867 Cell division inhibitor SulA; Region: SulA; cl01880 211586011868 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 211586011869 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 211586011870 Cupredoxin superfamily; Region: Cupredoxin; cl19115 211586011871 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 211586011872 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 211586011873 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 211586011874 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 211586011875 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 211586011876 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 211586011877 Subunit I/III interface [polypeptide binding]; other site 211586011878 D-pathway; other site 211586011879 Subunit I/VIIc interface [polypeptide binding]; other site 211586011880 Subunit I/IV interface [polypeptide binding]; other site 211586011881 Subunit I/II interface [polypeptide binding]; other site 211586011882 Low-spin heme (heme a) binding site [chemical binding]; other site 211586011883 Subunit I/VIIa interface [polypeptide binding]; other site 211586011884 Subunit I/VIa interface [polypeptide binding]; other site 211586011885 Dimer interface; other site 211586011886 Putative water exit pathway; other site 211586011887 Binuclear center (heme a3/CuB) [ion binding]; other site 211586011888 K-pathway; other site 211586011889 Subunit I/Vb interface [polypeptide binding]; other site 211586011890 Putative proton exit pathway; other site 211586011891 Subunit I/VIb interface; other site 211586011892 Subunit I/VIc interface [polypeptide binding]; other site 211586011893 Electron transfer pathway; other site 211586011894 Subunit I/VIIIb interface [polypeptide binding]; other site 211586011895 Subunit I/VIIb interface [polypeptide binding]; other site 211586011896 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 211586011897 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 211586011898 Subunit III/VIIa interface [polypeptide binding]; other site 211586011899 Phospholipid binding site [chemical binding]; other site 211586011900 Subunit I/III interface [polypeptide binding]; other site 211586011901 Subunit III/VIb interface [polypeptide binding]; other site 211586011902 Subunit III/VIa interface; other site 211586011903 Subunit III/Vb interface [polypeptide binding]; other site 211586011904 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 211586011905 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 211586011906 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 211586011907 putative active site [active] 211586011908 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 211586011909 Cu(I) binding site [ion binding]; other site 211586011910 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973 211586011911 putative active site [active] 211586011912 putative metal binding site [ion binding]; other site 211586011913 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 211586011914 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 211586011915 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 211586011916 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 211586011917 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 211586011918 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 211586011919 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 211586011920 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 211586011921 FMN-binding domain; Region: FMN_bind; pfam04205 211586011922 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 211586011923 L-aspartate oxidase; Provisional; Region: PRK06175 211586011924 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 211586011925 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211586011926 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586011927 dimer interface [polypeptide binding]; other site 211586011928 phosphorylation site [posttranslational modification] 211586011929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586011930 ATP binding site [chemical binding]; other site 211586011931 Mg2+ binding site [ion binding]; other site 211586011932 G-X-G motif; other site 211586011933 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211586011934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586011935 active site 211586011936 phosphorylation site [posttranslational modification] 211586011937 intermolecular recognition site; other site 211586011938 dimerization interface [polypeptide binding]; other site 211586011939 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211586011940 DNA binding site [nucleotide binding] 211586011941 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 211586011942 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 211586011943 dimerization interface [polypeptide binding]; other site 211586011944 DNA binding residues [nucleotide binding] 211586011945 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 211586011946 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 211586011947 active site 211586011948 carboxylesterase BioH; Provisional; Region: PRK10349 211586011949 Putative lysophospholipase; Region: Hydrolase_4; cl19140 211586011950 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 211586011951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 211586011952 Sulfatase; Region: Sulfatase; pfam00884 211586011953 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 211586011954 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 211586011955 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 211586011956 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 211586011957 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 211586011958 RNA binding site [nucleotide binding]; other site 211586011959 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 211586011960 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 211586011961 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 211586011962 osmolarity response regulator; Provisional; Region: ompR; PRK09468 211586011963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586011964 active site 211586011965 phosphorylation site [posttranslational modification] 211586011966 intermolecular recognition site; other site 211586011967 dimerization interface [polypeptide binding]; other site 211586011968 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211586011969 DNA binding site [nucleotide binding] 211586011970 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 211586011971 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586011972 dimerization interface [polypeptide binding]; other site 211586011973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586011974 dimer interface [polypeptide binding]; other site 211586011975 phosphorylation site [posttranslational modification] 211586011976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586011977 ATP binding site [chemical binding]; other site 211586011978 Mg2+ binding site [ion binding]; other site 211586011979 G-X-G motif; other site 211586011980 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 211586011981 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586011982 dimerization interface [polypeptide binding]; other site 211586011983 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 211586011984 dimer interface [polypeptide binding]; other site 211586011985 putative CheW interface [polypeptide binding]; other site 211586011986 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211586011987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586011988 active site 211586011989 phosphorylation site [posttranslational modification] 211586011990 intermolecular recognition site; other site 211586011991 dimerization interface [polypeptide binding]; other site 211586011992 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211586011993 DNA binding site [nucleotide binding] 211586011994 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211586011995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586011996 dimer interface [polypeptide binding]; other site 211586011997 phosphorylation site [posttranslational modification] 211586011998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586011999 ATP binding site [chemical binding]; other site 211586012000 Mg2+ binding site [ion binding]; other site 211586012001 G-X-G motif; other site 211586012002 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 211586012003 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 211586012004 catalytic triad [active] 211586012005 dimer interface [polypeptide binding]; other site 211586012006 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 211586012007 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 211586012008 GlyGly-CTERM domain; Region: GlyGly_CTERM; TIGR03501 211586012009 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 211586012010 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211586012011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586012012 active site 211586012013 phosphorylation site [posttranslational modification] 211586012014 intermolecular recognition site; other site 211586012015 dimerization interface [polypeptide binding]; other site 211586012016 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 211586012017 DNA binding site [nucleotide binding] 211586012018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211586012019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586012020 dimer interface [polypeptide binding]; other site 211586012021 phosphorylation site [posttranslational modification] 211586012022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586012023 ATP binding site [chemical binding]; other site 211586012024 Mg2+ binding site [ion binding]; other site 211586012025 G-X-G motif; other site 211586012026 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 211586012027 Serine hydrolase; Region: Ser_hydrolase; pfam06821 211586012028 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 211586012029 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 211586012030 PBP superfamily domain; Region: PBP_like; cl17867 211586012031 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 211586012032 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 211586012033 membrane-bound complex binding site; other site 211586012034 hinge residues; other site 211586012035 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 211586012036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211586012037 dimer interface [polypeptide binding]; other site 211586012038 conserved gate region; other site 211586012039 putative PBP binding loops; other site 211586012040 ABC-ATPase subunit interface; other site 211586012041 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 211586012042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211586012043 dimer interface [polypeptide binding]; other site 211586012044 conserved gate region; other site 211586012045 putative PBP binding loops; other site 211586012046 ABC-ATPase subunit interface; other site 211586012047 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 211586012048 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 211586012049 Walker A/P-loop; other site 211586012050 ATP binding site [chemical binding]; other site 211586012051 Q-loop/lid; other site 211586012052 ABC transporter signature motif; other site 211586012053 Walker B; other site 211586012054 D-loop; other site 211586012055 H-loop/switch region; other site 211586012056 TOBE-like domain; Region: TOBE_3; pfam12857 211586012057 MASE1; Region: MASE1; cl17823 211586012058 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 211586012059 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 211586012060 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586012061 putative active site [active] 211586012062 heme pocket [chemical binding]; other site 211586012063 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586012064 putative active site [active] 211586012065 heme pocket [chemical binding]; other site 211586012066 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 211586012067 metal binding site [ion binding]; metal-binding site 211586012068 active site 211586012069 I-site; other site 211586012070 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586012071 Putative SAM-dependent methyltransferase; Region: SAM_MT; pfam04445 211586012072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586012073 S-adenosylmethionine binding site [chemical binding]; other site 211586012074 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 211586012075 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 211586012076 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 211586012077 N-acetyl-D-glucosamine binding site [chemical binding]; other site 211586012078 catalytic residue [active] 211586012079 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 211586012080 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 211586012081 Cytochrome c553 [Energy production and conversion]; Region: COG2863 211586012082 Cytochrome c; Region: Cytochrom_C; cl11414 211586012083 Predicted GTPase [General function prediction only]; Region: COG0218 211586012084 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 211586012085 G1 box; other site 211586012086 GTP/Mg2+ binding site [chemical binding]; other site 211586012087 Switch I region; other site 211586012088 G2 box; other site 211586012089 G3 box; other site 211586012090 Switch II region; other site 211586012091 G4 box; other site 211586012092 G5 box; other site 211586012093 DNA polymerase I; Provisional; Region: PRK05755 211586012094 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 211586012095 active site 211586012096 metal binding site 1 [ion binding]; metal-binding site 211586012097 putative 5' ssDNA interaction site; other site 211586012098 metal binding site 3; metal-binding site 211586012099 metal binding site 2 [ion binding]; metal-binding site 211586012100 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 211586012101 putative DNA binding site [nucleotide binding]; other site 211586012102 putative metal binding site [ion binding]; other site 211586012103 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 211586012104 active site 211586012105 catalytic site [active] 211586012106 substrate binding site [chemical binding]; other site 211586012107 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 211586012108 active site 211586012109 DNA binding site [nucleotide binding] 211586012110 catalytic site [active] 211586012111 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 211586012112 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 211586012113 conserved cys residue [active] 211586012114 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 211586012115 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 211586012116 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 211586012117 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 211586012118 active site residue [active] 211586012119 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 211586012120 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 211586012121 NAD(P) binding site [chemical binding]; other site 211586012122 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 211586012123 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 211586012124 substrate-cofactor binding pocket; other site 211586012125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 211586012126 catalytic residue [active] 211586012127 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 211586012128 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 211586012129 Bacterial transcriptional repressor; Region: TetR; pfam13972 211586012130 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 211586012131 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 211586012132 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 211586012133 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 211586012134 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 211586012135 putative active site [active] 211586012136 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 211586012137 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 211586012138 putative ADP-binding pocket [chemical binding]; other site 211586012139 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; cl19502 211586012140 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 211586012141 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 211586012142 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 211586012143 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 211586012144 putative ADP-binding pocket [chemical binding]; other site 211586012145 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 211586012146 active site 211586012147 (T/H)XGH motif; other site 211586012148 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 211586012149 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 211586012150 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 211586012151 putative NAD(P) binding site [chemical binding]; other site 211586012152 active site 211586012153 putative substrate binding site [chemical binding]; other site 211586012154 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 211586012155 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 211586012156 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 211586012157 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 211586012158 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 211586012159 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 211586012160 Ligand binding site; other site 211586012161 Putative Catalytic site; other site 211586012162 DXD motif; other site 211586012163 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 211586012164 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 211586012165 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 211586012166 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 211586012167 MMPL family; Region: MMPL; cl14618 211586012168 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 211586012169 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 211586012170 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586012171 conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001 211586012172 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 211586012173 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 211586012174 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 211586012175 C-terminal domain interface [polypeptide binding]; other site 211586012176 GSH binding site (G-site) [chemical binding]; other site 211586012177 dimer interface [polypeptide binding]; other site 211586012178 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 211586012179 N-terminal domain interface [polypeptide binding]; other site 211586012180 dimer interface [polypeptide binding]; other site 211586012181 substrate binding pocket (H-site) [chemical binding]; other site 211586012182 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 211586012183 active site 211586012184 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 211586012185 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 211586012186 active site 211586012187 Zn binding site [ion binding]; other site 211586012188 glutathione reductase; Validated; Region: PRK06116 211586012189 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 211586012190 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 211586012191 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 211586012192 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 211586012193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211586012194 non-specific DNA binding site [nucleotide binding]; other site 211586012195 salt bridge; other site 211586012196 sequence-specific DNA binding site [nucleotide binding]; other site 211586012197 Domain of unknown function (DUF955); Region: DUF955; cl01076 211586012198 Protein of unknown function (DUF3612); Region: DUF3612; pfam12268 211586012199 malate synthase; Provisional; Region: PRK08951 211586012200 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586012201 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586012202 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 211586012203 Paraquat-inducible protein A; Region: PqiA; pfam04403 211586012204 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 211586012205 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 211586012206 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 211586012207 Zn2+ binding site [ion binding]; other site 211586012208 Mg2+ binding site [ion binding]; other site 211586012209 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 211586012210 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 211586012211 Walker A/P-loop; other site 211586012212 ATP binding site [chemical binding]; other site 211586012213 Q-loop/lid; other site 211586012214 ABC transporter signature motif; other site 211586012215 Walker B; other site 211586012216 D-loop; other site 211586012217 H-loop/switch region; other site 211586012218 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 211586012219 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 211586012220 Walker A/P-loop; other site 211586012221 ATP binding site [chemical binding]; other site 211586012222 Q-loop/lid; other site 211586012223 ABC transporter signature motif; other site 211586012224 Walker B; other site 211586012225 D-loop; other site 211586012226 H-loop/switch region; other site 211586012227 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 211586012228 chorismate binding enzyme; Region: Chorismate_bind; cl10555 211586012229 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 211586012230 hypothetical protein; Provisional; Region: PRK11212 211586012231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586012232 Coenzyme A binding pocket [chemical binding]; other site 211586012233 HAMP domain; Region: HAMP; pfam00672 211586012234 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 211586012235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 211586012236 dimer interface [polypeptide binding]; other site 211586012237 phosphorylation site [posttranslational modification] 211586012238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 211586012239 ATP binding site [chemical binding]; other site 211586012240 Mg2+ binding site [ion binding]; other site 211586012241 G-X-G motif; other site 211586012242 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 211586012243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 211586012244 active site 211586012245 phosphorylation site [posttranslational modification] 211586012246 intermolecular recognition site; other site 211586012247 dimerization interface [polypeptide binding]; other site 211586012248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 211586012249 Walker A motif; other site 211586012250 ATP binding site [chemical binding]; other site 211586012251 Walker B motif; other site 211586012252 arginine finger; other site 211586012253 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 211586012254 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 211586012255 dimerization interface [polypeptide binding]; other site 211586012256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 211586012257 dimer interface [polypeptide binding]; other site 211586012258 conserved gate region; other site 211586012259 putative PBP binding loops; other site 211586012260 ABC-ATPase subunit interface; other site 211586012261 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 211586012262 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 211586012263 Walker A/P-loop; other site 211586012264 ATP binding site [chemical binding]; other site 211586012265 Q-loop/lid; other site 211586012266 ABC transporter signature motif; other site 211586012267 Walker B; other site 211586012268 D-loop; other site 211586012269 H-loop/switch region; other site 211586012270 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 211586012271 GTP binding site; other site 211586012272 putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional; Region: PRK14491 211586012273 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 211586012274 Walker A motif; other site 211586012275 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 211586012276 dimer interface [polypeptide binding]; other site 211586012277 putative functional site; other site 211586012278 putative MPT binding site; other site 211586012279 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 211586012280 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211586012281 FeS/SAM binding site; other site 211586012282 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 211586012283 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 211586012284 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 211586012285 DNA binding site [nucleotide binding] 211586012286 catalytic residue [active] 211586012287 H2TH interface [polypeptide binding]; other site 211586012288 putative catalytic residues [active] 211586012289 turnover-facilitating residue; other site 211586012290 intercalation triad [nucleotide binding]; other site 211586012291 8OG recognition residue [nucleotide binding]; other site 211586012292 putative reading head residues; other site 211586012293 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 211586012294 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 211586012295 Methyltransferase domain; Region: Methyltransf_23; pfam13489 211586012296 Der GTPase activator (YihI); Region: YihI; pfam04220 211586012297 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 211586012298 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 211586012299 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 211586012300 FeS/SAM binding site; other site 211586012301 HemN C-terminal domain; Region: HemN_C; pfam06969 211586012302 adenosine deaminase; Provisional; Region: PRK09358 211586012303 active site 211586012304 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 211586012305 lysophospholipase L2; Provisional; Region: PRK10749 211586012306 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 211586012307 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 211586012308 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 211586012309 PAS fold; Region: PAS_3; pfam08447 211586012310 putative active site [active] 211586012311 heme pocket [chemical binding]; other site 211586012312 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 211586012313 nucleotidyl binding site; other site 211586012314 metal binding site [ion binding]; metal-binding site 211586012315 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 211586012316 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 211586012317 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 211586012318 4Fe-4S binding domain; Region: Fer4_5; pfam12801 211586012319 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 211586012320 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 211586012321 IG-like fold at C-terminal of FixG, putative oxidoreductase; Region: FixG_C; pfam11614 211586012322 Dihydroxynaphthoic acid synthase [Coenzyme metabolism]; Region: MenB; COG0447 211586012323 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 211586012324 substrate binding site [chemical binding]; other site 211586012325 oxyanion hole (OAH) forming residues; other site 211586012326 trimer interface [polypeptide binding]; other site 211586012327 Predicted membrane protein [Function unknown]; Region: COG3205 211586012328 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 211586012329 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 211586012330 glutaminase active site [active] 211586012331 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 211586012332 dimer interface [polypeptide binding]; other site 211586012333 active site 211586012334 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 211586012335 dimer interface [polypeptide binding]; other site 211586012336 active site 211586012337 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 211586012338 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 211586012339 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 211586012340 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 211586012341 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 211586012342 N-terminal plug; other site 211586012343 ligand-binding site [chemical binding]; other site 211586012344 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 211586012345 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 211586012346 Substrate binding site; other site 211586012347 Mg++ binding site; other site 211586012348 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 211586012349 active site 211586012350 substrate binding site [chemical binding]; other site 211586012351 CoA binding site [chemical binding]; other site 211586012352 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 211586012353 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 211586012354 gamma subunit interface [polypeptide binding]; other site 211586012355 epsilon subunit interface [polypeptide binding]; other site 211586012356 LBP interface [polypeptide binding]; other site 211586012357 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 211586012358 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 211586012359 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 211586012360 alpha subunit interaction interface [polypeptide binding]; other site 211586012361 Walker A motif; other site 211586012362 ATP binding site [chemical binding]; other site 211586012363 Walker B motif; other site 211586012364 inhibitor binding site; inhibition site 211586012365 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 211586012366 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 211586012367 core domain interface [polypeptide binding]; other site 211586012368 delta subunit interface [polypeptide binding]; other site 211586012369 epsilon subunit interface [polypeptide binding]; other site 211586012370 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 211586012371 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 211586012372 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 211586012373 beta subunit interaction interface [polypeptide binding]; other site 211586012374 Walker A motif; other site 211586012375 ATP binding site [chemical binding]; other site 211586012376 Walker B motif; other site 211586012377 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 211586012378 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 211586012379 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 211586012380 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 211586012381 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 211586012382 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 211586012383 ATP synthase I chain; Region: ATP_synt_I; cl09170 211586012384 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 211586012385 ParB-like nuclease domain; Region: ParBc; pfam02195 211586012386 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 211586012387 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 211586012388 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 211586012389 P-loop; other site 211586012390 Magnesium ion binding site [ion binding]; other site 211586012391 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 211586012392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586012393 S-adenosylmethionine binding site [chemical binding]; other site 211586012394 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 211586012395 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 211586012396 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 211586012397 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 211586012398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211586012399 non-specific DNA binding site [nucleotide binding]; other site 211586012400 salt bridge; other site 211586012401 sequence-specific DNA binding site [nucleotide binding]; other site 211586012402 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 211586012403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 211586012404 S-adenosylmethionine binding site [chemical binding]; other site 211586012405 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 211586012406 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 211586012407 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 211586012408 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 211586012409 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 211586012410 P-loop; other site 211586012411 Magnesium ion binding site [ion binding]; other site 211586012412 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 211586012413 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 211586012414 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 211586012415 active site 211586012416 DNA binding site [nucleotide binding] 211586012417 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 211586012418 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 211586012419 Catalytic site [active] 211586012420 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 211586012421 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 211586012422 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 211586012423 Uncharacterized conserved protein [Function unknown]; Region: COG2361 211586012424 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 211586012425 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 211586012426 catalytic residues [active] 211586012427 catalytic nucleophile [active] 211586012428 Presynaptic Site I dimer interface [polypeptide binding]; other site 211586012429 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 211586012430 Synaptic Flat tetramer interface [polypeptide binding]; other site 211586012431 Synaptic Site I dimer interface [polypeptide binding]; other site 211586012432 DNA binding site [nucleotide binding] 211586012433 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 211586012434 DNA-binding interface [nucleotide binding]; DNA binding site 211586012435 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 211586012436 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211586012437 sequence-specific DNA binding site [nucleotide binding]; other site 211586012438 salt bridge; other site 211586012439 Transposase; Region: HTH_Tnp_1; pfam01527 211586012440 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586012441 putative transposase OrfB; Reviewed; Region: PHA02517 211586012442 HTH-like domain; Region: HTH_21; pfam13276 211586012443 Integrase core domain; Region: rve; pfam00665 211586012444 Integrase core domain; Region: rve_2; pfam13333 211586012445 putative transposase OrfB; Reviewed; Region: PHA02517 211586012446 HTH-like domain; Region: HTH_21; pfam13276 211586012447 Integrase core domain; Region: rve; pfam00665 211586012448 Integrase core domain; Region: rve_2; pfam13333 211586012449 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 211586012450 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 211586012451 Transposase; Region: HTH_Tnp_1; pfam01527 211586012452 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586012453 putative transposase OrfB; Reviewed; Region: PHA02517 211586012454 HTH-like domain; Region: HTH_21; pfam13276 211586012455 Integrase core domain; Region: rve; pfam00665 211586012456 Integrase core domain; Region: rve_2; pfam13333 211586012457 putative transposase OrfB; Reviewed; Region: PHA02517 211586012458 HTH-like domain; Region: HTH_21; pfam13276 211586012459 Integrase core domain; Region: rve; pfam00665 211586012460 Integrase core domain; Region: rve_2; pfam13333 211586012461 ParB-like nuclease domain; Region: ParBc; pfam02195 211586012462 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 211586012463 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586012464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586012465 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 211586012466 Transposase; Region: HTH_Tnp_1; pfam01527 211586012467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586012468 putative transposase OrfB; Reviewed; Region: PHA02517 211586012469 HTH-like domain; Region: HTH_21; pfam13276 211586012470 Integrase core domain; Region: rve; pfam00665 211586012471 Integrase core domain; Region: rve_2; pfam13333 211586012472 putative transposase OrfB; Reviewed; Region: PHA02517 211586012473 HTH-like domain; Region: HTH_21; pfam13276 211586012474 Integrase core domain; Region: rve; pfam00665 211586012475 Integrase core domain; Region: rve_2; pfam13333 211586012476 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 211586012477 PemK-like protein; Region: PemK; pfam02452 211586012478 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 211586012479 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 211586012480 active site 211586012481 DNA binding site [nucleotide binding] 211586012482 Int/Topo IB signature motif; other site 211586012483 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 211586012484 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 211586012485 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 211586012486 active site 211586012487 catalytic residues [active] 211586012488 DNA binding site [nucleotide binding] 211586012489 Int/Topo IB signature motif; other site 211586012490 Dienelactone hydrolase family; Region: DLH; pfam01738 211586012491 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 211586012492 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 211586012493 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 211586012494 putative active site [active] 211586012495 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 211586012496 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 211586012497 Walker A/P-loop; other site 211586012498 ATP binding site [chemical binding]; other site 211586012499 Q-loop/lid; other site 211586012500 ABC transporter signature motif; other site 211586012501 Walker B; other site 211586012502 D-loop; other site 211586012503 H-loop/switch region; other site 211586012504 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 211586012505 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586012506 Transposase; Region: HTH_Tnp_1; pfam01527 211586012507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586012508 putative transposase OrfB; Reviewed; Region: PHA02517 211586012509 HTH-like domain; Region: HTH_21; pfam13276 211586012510 Integrase core domain; Region: rve; pfam00665 211586012511 Integrase core domain; Region: rve_2; pfam13333 211586012512 putative transposase OrfB; Reviewed; Region: PHA02517 211586012513 HTH-like domain; Region: HTH_21; pfam13276 211586012514 Integrase core domain; Region: rve; pfam00665 211586012515 Integrase core domain; Region: rve_2; pfam13333 211586012516 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 211586012517 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 211586012518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 211586012519 Coenzyme A binding pocket [chemical binding]; other site 211586012520 ParA-like protein; Provisional; Region: PHA02518 211586012521 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 211586012522 P-loop; other site 211586012523 Magnesium ion binding site [ion binding]; other site 211586012524 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 211586012525 Integrase core domain; Region: rve; pfam00665 211586012526 Transposase; Region: HTH_Tnp_1; pfam01527 211586012527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586012528 putative transposase OrfB; Reviewed; Region: PHA02517 211586012529 HTH-like domain; Region: HTH_21; pfam13276 211586012530 Integrase core domain; Region: rve; pfam00665 211586012531 Integrase core domain; Region: rve_2; pfam13333 211586012532 putative transposase OrfB; Reviewed; Region: PHA02517 211586012533 HTH-like domain; Region: HTH_21; pfam13276 211586012534 Integrase core domain; Region: rve; pfam00665 211586012535 Integrase core domain; Region: rve_2; pfam13333 211586012536 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 211586012537 non-specific DNA binding site [nucleotide binding]; other site 211586012538 salt bridge; other site 211586012539 sequence-specific DNA binding site [nucleotide binding]; other site 211586012540 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 211586012541 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 211586012542 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 211586012543 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 211586012544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 211586012545 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 211586012546 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586012547 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 211586012548 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 211586012549 ParA-like protein; Provisional; Region: PHA02518 211586012550 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 211586012551 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 211586012552 catalytic residues [active] 211586012553 catalytic nucleophile [active] 211586012554 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 211586012555 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 211586012556 Immunity protein 14; Region: Imm14; pfam15428 211586012557 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586012558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586012559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 211586012560 Integrase core domain; Region: rve; pfam00665 211586012561 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 211586012562 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 211586012563 catalytic residues [active] 211586012564 catalytic nucleophile [active] 211586012565 Presynaptic Site I dimer interface [polypeptide binding]; other site 211586012566 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 211586012567 Synaptic Flat tetramer interface [polypeptide binding]; other site 211586012568 Synaptic Site I dimer interface [polypeptide binding]; other site 211586012569 DNA binding site [nucleotide binding] 211586012570 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 211586012571 DNA-binding interface [nucleotide binding]; DNA binding site 211586012572 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 211586012573 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 211586012574 Transposase; Region: HTH_Tnp_1; pfam01527 211586012575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 211586012576 putative transposase OrfB; Reviewed; Region: PHA02517 211586012577 HTH-like domain; Region: HTH_21; pfam13276 211586012578 Integrase core domain; Region: rve; pfam00665 211586012579 Integrase core domain; Region: rve_2; pfam13333 211586012580 putative transposase OrfB; Reviewed; Region: PHA02517 211586012581 HTH-like domain; Region: HTH_21; pfam13276 211586012582 Integrase core domain; Region: rve; pfam00665 211586012583 Integrase core domain; Region: rve_2; pfam13333 211586012584 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 211586012585 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 211586012586 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 211586012587 P-loop; other site 211586012588 Magnesium ion binding site [ion binding]; other site 211586012589 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 211586012590 MarR family; Region: MarR_2; pfam12802 211586012591 ParB family; Region: ParB; pfam08775 211586012592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 211586012593 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 211586012594 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586012595 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 211586012596 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 211586012597 Ion channel; Region: Ion_trans_2; pfam07885 211586012598 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 211586012599 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 211586012600 active site 211586012601 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 211586012602 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 211586012603 active site 211586012604 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 211586012605 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586012606 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 211586012607 Integrase core domain; Region: rve; pfam00665 211586012608 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 211586012609 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 211586012610 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 211586012611 dimerization interface [polypeptide binding]; other site 211586012612 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 211586012613 dimer interface [polypeptide binding]; other site 211586012614 putative CheW interface [polypeptide binding]; other site 211586012615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 211586012616 EAL domain; Region: EAL; pfam00563 211586012617 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 211586012618 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 211586012619 outer membrane protein A; Reviewed; Region: PRK10808 211586012620 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 211586012621 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 211586012622 ligand binding site [chemical binding]; other site 211586012623 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 211586012624 HTH-like domain; Region: HTH_21; pfam13276 211586012625 Winged helix-turn helix; Region: HTH_29; pfam13551 211586012626 Helix-turn-helix domain; Region: HTH_28; pfam13518 211586012627 Integrase core domain; Region: rve; pfam00665 211586012628 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 211586012629 Integrase core domain; Region: rve_3; pfam13683 211586012630 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 211586012631 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586012632 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 211586012633 Helix-turn-helix domain; Region: HTH_38; pfam13936 211586012634 putative transposase OrfB; Reviewed; Region: PHA02517 211586012635 HTH-like domain; Region: HTH_21; pfam13276 211586012636 Integrase core domain; Region: rve; pfam00665 211586012637 Integrase core domain; Region: rve_2; pfam13333 211586012638 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586012639 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586012640 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 211586012641 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 211586012642 DNA binding site [nucleotide binding] 211586012643 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586012644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 211586012645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 211586012646 Winged helix-turn helix; Region: HTH_29; pfam13551 211586012647 Helix-turn-helix domain; Region: HTH_28; pfam13518 211586012648 Integrase core domain; Region: rve; pfam00665 211586012649 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 211586012650 Integrase core domain; Region: rve_3; pfam13683 211586012651 Transposase, Mutator family; Region: Transposase_mut; cl19537 211586012652 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 211586012653 HTH-like domain; Region: HTH_21; pfam13276 211586012654 Integrase core domain; Region: rve; pfam00665 211586012655 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 211586012656 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 211586012657 Winged helix-turn helix; Region: HTH_29; pfam13551 211586012658 Helix-turn-helix domain; Region: HTH_28; pfam13518 211586012659 Integrase core domain; Region: rve; pfam00665 211586012660 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 211586012661 Integrase core domain; Region: rve_3; pfam13683 211586012662 Predicted transcriptional regulator [Transcription]; Region: COG2944 211586012663 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 211586012664 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 211586012665 HlyD family secretion protein; Region: HlyD_3; pfam13437 211586012666 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 211586012667 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 211586012668 Predicted esterase [General function prediction only]; Region: COG0627 211586012669 S-formylglutathione hydrolase; Region: PLN02442 211586012670 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 211586012671 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 211586012672 substrate binding site [chemical binding]; other site 211586012673 catalytic Zn binding site [ion binding]; other site 211586012674 NAD binding site [chemical binding]; other site 211586012675 structural Zn binding site [ion binding]; other site 211586012676 dimer interface [polypeptide binding]; other site 211586012677 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 211586012678 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 211586012679 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 211586012680 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 211586012681 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 211586012682 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 211586012683 dimer interface [polypeptide binding]; other site 211586012684 active site 211586012685 metal binding site [ion binding]; metal-binding site 211586012686 Transcriptional regulator [Transcription]; Region: LysR; COG0583 211586012687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 211586012688 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 211586012689 putative effector binding pocket; other site 211586012690 putative dimerization interface [polypeptide binding]; other site 211586012691 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 211586012692 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 211586012693 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 211586012694 Uncharacterized conserved protein [Function unknown]; Region: COG2361 211586012695 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 211586012696 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 211586012697 catalytic residues [active] 211586012698 catalytic nucleophile [active] 211586012699 Presynaptic Site I dimer interface [polypeptide binding]; other site 211586012700 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 211586012701 Synaptic Flat tetramer interface [polypeptide binding]; other site 211586012702 Synaptic Site I dimer interface [polypeptide binding]; other site 211586012703 DNA binding site [nucleotide binding] 211586012704 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 211586012705 DNA-binding interface [nucleotide binding]; DNA binding site 211586012706 multiple promoter invertase; Provisional; Region: mpi; PRK13413 211586012707 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 211586012708 catalytic residues [active] 211586012709 catalytic nucleophile [active] 211586012710 Presynaptic Site I dimer interface [polypeptide binding]; other site 211586012711 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 211586012712 Synaptic Flat tetramer interface [polypeptide binding]; other site 211586012713 Synaptic Site I dimer interface [polypeptide binding]; other site 211586012714 DNA binding site [nucleotide binding] 211586012715 Helix-turn-helix domain; Region: HTH_38; pfam13936