-- dump date   	20140620_064617
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
637905000001	FMN-binding protein MioC; Provisional; Region: PRK09004
637905000002	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
637905000003	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
637905000004	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
637905000005	Cytochrome c; Region: Cytochrom_C; pfam00034
637905000006	Cytochrome c; Region: Cytochrom_C; pfam00034
637905000007	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
637905000008	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
637905000009	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
637905000010	Subunit I/III interface [polypeptide binding]; other site
637905000011	Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864
637905000012	Subunit I/III interface [polypeptide binding]; other site
637905000013	Predicted small integral membrane protein [Function unknown]; Region: COG5605
637905000014	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
637905000015	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
637905000016	Cu(I) binding site [ion binding]; other site
637905000017	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
637905000018	active site
637905000019	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
637905000020	Protein of unknown function (DUF1186); Region: DUF1186; pfam06685
637905000021	SEC-C motif; Region: SEC-C; pfam02810
637905000022	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
637905000023	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
637905000024	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203
637905000025	PLD-like domain; Region: PLDc_2; pfam13091
637905000026	putative homodimer interface [polypeptide binding]; other site
637905000027	putative active site [active]
637905000028	catalytic site [active]
637905000029	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
637905000030	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637905000031	ATP binding site [chemical binding]; other site
637905000032	putative Mg++ binding site [ion binding]; other site
637905000033	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905000034	nucleotide binding region [chemical binding]; other site
637905000035	ATP-binding site [chemical binding]; other site
637905000036	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
637905000037	Fic family protein [Function unknown]; Region: COG3177
637905000038	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
637905000039	Fic/DOC family; Region: Fic; pfam02661
637905000040	Survival protein SurE; Region: SurE; cl00448
637905000041	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
637905000042	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637905000043	ATP binding site [chemical binding]; other site
637905000044	putative Mg++ binding site [ion binding]; other site
637905000045	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905000046	nucleotide binding region [chemical binding]; other site
637905000047	ATP-binding site [chemical binding]; other site
637905000048	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
637905000049	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
637905000050	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
637905000051	trmE is a tRNA modification GTPase; Region: trmE; cd04164
637905000052	G1 box; other site
637905000053	GTP/Mg2+ binding site [chemical binding]; other site
637905000054	Switch I region; other site
637905000055	G2 box; other site
637905000056	Switch II region; other site
637905000057	G3 box; other site
637905000058	G4 box; other site
637905000059	G5 box; other site
637905000060	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
637905000061	membrane protein insertase; Provisional; Region: PRK01318
637905000062	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
637905000063	Haemolytic domain; Region: Haemolytic; pfam01809
637905000064	ribonuclease P; Reviewed; Region: rnpA; PRK01732
637905000065	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
637905000066	DnaA N-terminal domain; Region: DnaA_N; pfam11638
637905000067	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
637905000068	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905000069	Walker A motif; other site
637905000070	ATP binding site [chemical binding]; other site
637905000071	Walker B motif; other site
637905000072	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
637905000073	arginine finger; other site
637905000074	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
637905000075	DnaA box-binding interface [nucleotide binding]; other site
637905000076	DNA polymerase III subunit beta; Validated; Region: PRK05643
637905000077	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
637905000078	putative DNA binding surface [nucleotide binding]; other site
637905000079	dimer interface [polypeptide binding]; other site
637905000080	beta-clamp/clamp loader binding surface; other site
637905000081	beta-clamp/translesion DNA polymerase binding surface; other site
637905000082	recombination protein F; Reviewed; Region: recF; PRK00064
637905000083	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637905000084	Walker A/P-loop; other site
637905000085	ATP binding site [chemical binding]; other site
637905000086	Q-loop/lid; other site
637905000087	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637905000088	ABC transporter signature motif; other site
637905000089	Walker B; other site
637905000090	D-loop; other site
637905000091	H-loop/switch region; other site
637905000092	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
637905000093	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905000094	ATP binding site [chemical binding]; other site
637905000095	Mg2+ binding site [ion binding]; other site
637905000096	G-X-G motif; other site
637905000097	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
637905000098	anchoring element; other site
637905000099	dimer interface [polypeptide binding]; other site
637905000100	ATP binding site [chemical binding]; other site
637905000101	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
637905000102	active site
637905000103	putative metal-binding site [ion binding]; other site
637905000104	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
637905000105	uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801
637905000106	putative active site [active]
637905000107	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
637905000108	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
637905000109	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
637905000110	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
637905000111	metal binding site [ion binding]; metal-binding site
637905000112	HDOD domain; Region: HDOD; pfam08668
637905000113	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
637905000114	Zn2+ binding site [ion binding]; other site
637905000115	Mg2+ binding site [ion binding]; other site
637905000116	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
637905000117	DALR anticodon binding domain; Region: DALR_1; pfam05746
637905000118	anticodon binding site; other site
637905000119	tRNA binding surface [nucleotide binding]; other site
637905000120	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
637905000121	dimer interface [polypeptide binding]; other site
637905000122	motif 1; other site
637905000123	active site
637905000124	motif 2; other site
637905000125	motif 3; other site
637905000126	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
637905000127	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
637905000128	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
637905000129	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
637905000130	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
637905000131	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
637905000132	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
637905000133	active site
637905000134	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
637905000135	MOSC domain; Region: MOSC; pfam03473
637905000136	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
637905000137	CPxP  motif; other site
637905000138	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
637905000139	putative deacylase active site [active]
637905000140	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
637905000141	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637905000142	Coenzyme A binding pocket [chemical binding]; other site
637905000143	Neuraminyllactose-binding hemagglutinin precursor (NLBH); Region: NLBH; pfam05211
637905000144	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
637905000145	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
637905000146	dimer interface [polypeptide binding]; other site
637905000147	active site
637905000148	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
637905000149	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
637905000150	substrate binding site [chemical binding]; other site
637905000151	oxyanion hole (OAH) forming residues; other site
637905000152	trimer interface [polypeptide binding]; other site
637905000153	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
637905000154	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
637905000155	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
637905000156	proline dipeptidase; Provisional; Region: PRK13607
637905000157	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
637905000158	active site
637905000159	hypothetical protein; Provisional; Region: PRK11568
637905000160	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
637905000161	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
637905000162	Cation transport protein; Region: TrkH; cl17365
637905000163	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
637905000164	Flavodoxin domain; Region: Flavodoxin_5; cl17428
637905000165	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
637905000166	dimerization interface [polypeptide binding]; other site
637905000167	putative DNA binding site [nucleotide binding]; other site
637905000168	putative Zn2+ binding site [ion binding]; other site
637905000169	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
637905000170	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
637905000171	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
637905000172	TrkA-N domain; Region: TrkA_N; pfam02254
637905000173	TrkA-C domain; Region: TrkA_C; pfam02080
637905000174	TrkA-N domain; Region: TrkA_N; pfam02254
637905000175	TrkA-C domain; Region: TrkA_C; pfam02080
637905000176	16S rRNA methyltransferase B; Provisional; Region: PRK10901
637905000177	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
637905000178	putative RNA binding site [nucleotide binding]; other site
637905000179	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905000180	S-adenosylmethionine binding site [chemical binding]; other site
637905000181	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
637905000182	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
637905000183	putative active site [active]
637905000184	substrate binding site [chemical binding]; other site
637905000185	putative cosubstrate binding site; other site
637905000186	catalytic site [active]
637905000187	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
637905000188	substrate binding site [chemical binding]; other site
637905000189	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
637905000190	active site
637905000191	catalytic residues [active]
637905000192	metal binding site [ion binding]; metal-binding site
637905000193	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
637905000194	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
637905000195	DNA protecting protein DprA; Region: dprA; TIGR00732
637905000196	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
637905000197	Protein of unknown function (DUF494); Region: DUF494; pfam04361
637905000198	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
637905000199	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
637905000200	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
637905000201	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
637905000202	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
637905000203	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
637905000204	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
637905000205	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
637905000206	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
637905000207	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
637905000208	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
637905000209	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
637905000210	shikimate binding site; other site
637905000211	NAD(P) binding site [chemical binding]; other site
637905000212	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
637905000213	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
637905000214	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
637905000215	trimer interface [polypeptide binding]; other site
637905000216	putative metal binding site [ion binding]; other site
637905000217	enoyl-CoA hydratase; Provisional; Region: PRK06688
637905000218	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
637905000219	substrate binding site [chemical binding]; other site
637905000220	oxyanion hole (OAH) forming residues; other site
637905000221	trimer interface [polypeptide binding]; other site
637905000222	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
637905000223	Helix-turn-helix domain; Region: HTH_18; pfam12833
637905000224	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
637905000225	lysophospholipase L2; Provisional; Region: PRK10749
637905000226	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
637905000227	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
637905000228	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
637905000229	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637905000230	FeS/SAM binding site; other site
637905000231	HemN C-terminal domain; Region: HemN_C; pfam06969
637905000232	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
637905000233	Der GTPase activator; Provisional; Region: PRK05244
637905000234	Methyltransferase domain; Region: Methyltransf_23; pfam13489
637905000235	Cytochrome c553 [Energy production and conversion]; Region: COG2863
637905000236	Cytochrome c; Region: Cytochrom_C; cl11414
637905000237	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
637905000238	G1 box; other site
637905000239	GTP/Mg2+ binding site [chemical binding]; other site
637905000240	Switch I region; other site
637905000241	G2 box; other site
637905000242	G3 box; other site
637905000243	Switch II region; other site
637905000244	G4 box; other site
637905000245	G5 box; other site
637905000246	DNA polymerase I; Provisional; Region: PRK05755
637905000247	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
637905000248	active site
637905000249	metal binding site 1 [ion binding]; metal-binding site
637905000250	putative 5' ssDNA interaction site; other site
637905000251	metal binding site 3; metal-binding site
637905000252	metal binding site 2 [ion binding]; metal-binding site
637905000253	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
637905000254	putative DNA binding site [nucleotide binding]; other site
637905000255	putative metal binding site [ion binding]; other site
637905000256	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
637905000257	active site
637905000258	catalytic site [active]
637905000259	substrate binding site [chemical binding]; other site
637905000260	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
637905000261	active site
637905000262	DNA binding site [nucleotide binding]
637905000263	catalytic site [active]
637905000264	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
637905000265	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
637905000266	conserved cys residue [active]
637905000267	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
637905000268	rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239
637905000269	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
637905000270	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
637905000271	active site residue [active]
637905000272	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
637905000273	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
637905000274	NAD(P) binding site [chemical binding]; other site
637905000275	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
637905000276	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
637905000277	substrate-cofactor binding pocket; other site
637905000278	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905000279	catalytic residue [active]
637905000280	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
637905000281	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
637905000282	Bacterial transcriptional repressor; Region: TetR; pfam13972
637905000283	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
637905000284	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
637905000285	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
637905000286	3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723
637905000287	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
637905000288	active site
637905000289	ATP binding site [chemical binding]; other site
637905000290	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
637905000291	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
637905000292	NADP binding site [chemical binding]; other site
637905000293	active site
637905000294	putative substrate binding site [chemical binding]; other site
637905000295	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
637905000296	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
637905000297	N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420
637905000298	Substrate binding site; other site
637905000299	metal-binding site
637905000300	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
637905000301	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
637905000302	putative active site [active]
637905000303	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
637905000304	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
637905000305	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
637905000306	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
637905000307	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
637905000308	active site
637905000309	NAD binding site [chemical binding]; other site
637905000310	metal binding site [ion binding]; metal-binding site
637905000311	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
637905000312	active site
637905000313	nucleotide binding site [chemical binding]; other site
637905000314	HIGH motif; other site
637905000315	KMSKS motif; other site
637905000316	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
637905000317	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
637905000318	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
637905000319	NADP binding site [chemical binding]; other site
637905000320	homopentamer interface [polypeptide binding]; other site
637905000321	substrate binding site [chemical binding]; other site
637905000322	active site
637905000323	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
637905000324	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
637905000325	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
637905000326	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
637905000327	putative ribose interaction site [chemical binding]; other site
637905000328	putative ADP binding site [chemical binding]; other site
637905000329	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
637905000330	active site
637905000331	nucleotide binding site [chemical binding]; other site
637905000332	HIGH motif; other site
637905000333	KMSKS motif; other site
637905000334	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
637905000335	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
637905000336	active site
637905000337	(T/H)XGH motif; other site
637905000338	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
637905000339	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
637905000340	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
637905000341	DNA binding site [nucleotide binding]
637905000342	catalytic residue [active]
637905000343	H2TH interface [polypeptide binding]; other site
637905000344	putative catalytic residues [active]
637905000345	turnover-facilitating residue; other site
637905000346	intercalation triad [nucleotide binding]; other site
637905000347	8OG recognition residue [nucleotide binding]; other site
637905000348	putative reading head residues; other site
637905000349	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
637905000350	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
637905000351	putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional; Region: PRK14491
637905000352	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
637905000353	Walker A motif; other site
637905000354	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
637905000355	dimer interface [polypeptide binding]; other site
637905000356	putative functional site; other site
637905000357	putative MPT binding site; other site
637905000358	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
637905000359	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
637905000360	GTP binding site; other site
637905000361	hypothetical protein; Provisional; Region: PRK11212
637905000362	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
637905000363	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
637905000364	chorismate binding enzyme; Region: Chorismate_bind; cl10555
637905000365	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
637905000366	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
637905000367	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
637905000368	Zn2+ binding site [ion binding]; other site
637905000369	Mg2+ binding site [ion binding]; other site
637905000370	Paraquat-inducible protein A; Region: PqiA; pfam04403
637905000371	Predicted membrane protein [Function unknown]; Region: COG2855
637905000372	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
637905000373	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905000374	binding surface
637905000375	TPR motif; other site
637905000376	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905000377	binding surface
637905000378	TPR motif; other site
637905000379	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
637905000380	endo-1,4-D-glucanase; Provisional; Region: PRK11097
637905000381	cellulose synthase regulator protein; Provisional; Region: PRK11114
637905000382	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
637905000383	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
637905000384	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
637905000385	DXD motif; other site
637905000386	Cellulose synthase-like protein; Region: PLN02893
637905000387	PilZ domain; Region: PilZ; pfam07238
637905000388	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
637905000389	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
637905000390	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
637905000391	Protein of unknown function (DUF2819); Region: DUF2819; pfam10995
637905000392	Protein of unknown function (DUF3260); Region: DUF3260; pfam11658
637905000393	glutathione reductase; Validated; Region: PRK06116
637905000394	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
637905000395	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
637905000396	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
637905000397	oligopeptidase A; Provisional; Region: PRK10911
637905000398	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
637905000399	active site
637905000400	Zn binding site [ion binding]; other site
637905000401	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
637905000402	active site
637905000403	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
637905000404	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
637905000405	C-terminal domain interface [polypeptide binding]; other site
637905000406	GSH binding site (G-site) [chemical binding]; other site
637905000407	dimer interface [polypeptide binding]; other site
637905000408	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
637905000409	N-terminal domain interface [polypeptide binding]; other site
637905000410	dimer interface [polypeptide binding]; other site
637905000411	substrate binding pocket (H-site) [chemical binding]; other site
637905000412	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905000413	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905000414	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
637905000415	putative effector binding pocket; other site
637905000416	dimerization interface [polypeptide binding]; other site
637905000417	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
637905000418	conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001
637905000419	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
637905000420	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637905000421	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905000422	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
637905000423	Protein export membrane protein; Region: SecD_SecF; cl14618
637905000424	RDD family; Region: RDD; pfam06271
637905000425	AbgT putative transporter family; Region: ABG_transport; pfam03806
637905000426	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
637905000427	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
637905000428	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
637905000429	Penicillin amidase; Region: Penicil_amidase; pfam01804
637905000430	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
637905000431	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
637905000432	active site
637905000433	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
637905000434	LemA family; Region: LemA; cl00742
637905000435	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
637905000436	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
637905000437	N-acetyl-D-glucosamine binding site [chemical binding]; other site
637905000438	catalytic residue [active]
637905000439	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
637905000440	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
637905000441	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905000442	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905000443	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
637905000444	dimerization interface [polypeptide binding]; other site
637905000445	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
637905000446	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905000447	S-adenosylmethionine binding site [chemical binding]; other site
637905000448	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
637905000449	catalytic triad [active]
637905000450	dimer interface [polypeptide binding]; other site
637905000451	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905000452	dimerization interface [polypeptide binding]; other site
637905000453	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
637905000454	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905000455	dimer interface [polypeptide binding]; other site
637905000456	putative CheW interface [polypeptide binding]; other site
637905000457	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
637905000458	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905000459	dimerization interface [polypeptide binding]; other site
637905000460	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
637905000461	dimer interface [polypeptide binding]; other site
637905000462	phosphorylation site [posttranslational modification]
637905000463	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905000464	ATP binding site [chemical binding]; other site
637905000465	Mg2+ binding site [ion binding]; other site
637905000466	G-X-G motif; other site
637905000467	osmolarity response regulator; Provisional; Region: ompR; PRK09468
637905000468	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905000469	active site
637905000470	phosphorylation site [posttranslational modification]
637905000471	intermolecular recognition site; other site
637905000472	dimerization interface [polypeptide binding]; other site
637905000473	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637905000474	DNA binding site [nucleotide binding]
637905000475	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
637905000476	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
637905000477	active site
637905000478	metal binding site [ion binding]; metal-binding site
637905000479	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
637905000480	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
637905000481	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
637905000482	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905000483	S-adenosylmethionine binding site [chemical binding]; other site
637905000484	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
637905000485	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
637905000486	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
637905000487	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
637905000488	RNA binding site [nucleotide binding]; other site
637905000489	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
637905000490	Sulfatase; Region: Sulfatase; pfam00884
637905000491	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
637905000492	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
637905000493	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
637905000494	active site
637905000495	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238
637905000496	putative active site [active]
637905000497	Zn binding site [ion binding]; other site
637905000498	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
637905000499	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
637905000500	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
637905000501	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
637905000502	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
637905000503	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
637905000504	Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973
637905000505	putative active site [active]
637905000506	putative metal binding site [ion binding]; other site
637905000507	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
637905000508	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905000509	active site
637905000510	phosphorylation site [posttranslational modification]
637905000511	intermolecular recognition site; other site
637905000512	dimerization interface [polypeptide binding]; other site
637905000513	CheB methylesterase; Region: CheB_methylest; pfam01339
637905000514	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
637905000515	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
637905000516	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905000517	S-adenosylmethionine binding site [chemical binding]; other site
637905000518	PAS domain; Region: PAS_9; pfam13426
637905000519	PAS domain; Region: PAS_9; pfam13426
637905000520	PAS domain; Region: PAS_9; pfam13426
637905000521	PAS domain; Region: PAS_9; pfam13426
637905000522	PAS fold; Region: PAS_4; pfam08448
637905000523	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
637905000524	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905000525	dimer interface [polypeptide binding]; other site
637905000526	putative CheW interface [polypeptide binding]; other site
637905000527	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
637905000528	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
637905000529	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
637905000530	putative binding surface; other site
637905000531	active site
637905000532	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
637905000533	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905000534	ATP binding site [chemical binding]; other site
637905000535	G-X-G motif; other site
637905000536	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
637905000537	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
637905000538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905000539	active site
637905000540	phosphorylation site [posttranslational modification]
637905000541	intermolecular recognition site; other site
637905000542	dimerization interface [polypeptide binding]; other site
637905000543	STAS domain; Region: STAS_2; pfam13466
637905000544	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
637905000545	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
637905000546	Cu(I) binding site [ion binding]; other site
637905000547	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
637905000548	UbiA prenyltransferase family; Region: UbiA; pfam01040
637905000549	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
637905000550	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
637905000551	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
637905000552	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
637905000553	Subunit III/VIIa interface [polypeptide binding]; other site
637905000554	Phospholipid binding site [chemical binding]; other site
637905000555	Subunit I/III interface [polypeptide binding]; other site
637905000556	Subunit III/VIb interface [polypeptide binding]; other site
637905000557	Subunit III/VIa interface; other site
637905000558	Subunit III/Vb interface [polypeptide binding]; other site
637905000559	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
637905000560	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
637905000561	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
637905000562	Subunit I/III interface [polypeptide binding]; other site
637905000563	D-pathway; other site
637905000564	Subunit I/VIIc interface [polypeptide binding]; other site
637905000565	Subunit I/IV interface [polypeptide binding]; other site
637905000566	Subunit I/II interface [polypeptide binding]; other site
637905000567	Low-spin heme (heme a) binding site [chemical binding]; other site
637905000568	Subunit I/VIIa interface [polypeptide binding]; other site
637905000569	Subunit I/VIa interface [polypeptide binding]; other site
637905000570	Dimer interface; other site
637905000571	Putative water exit pathway; other site
637905000572	Binuclear center (heme a3/CuB) [ion binding]; other site
637905000573	K-pathway; other site
637905000574	Subunit I/Vb interface [polypeptide binding]; other site
637905000575	Putative proton exit pathway; other site
637905000576	Subunit I/VIb interface; other site
637905000577	Subunit I/VIc interface [polypeptide binding]; other site
637905000578	Electron transfer pathway; other site
637905000579	Subunit I/VIIIb interface [polypeptide binding]; other site
637905000580	Subunit I/VIIb interface [polypeptide binding]; other site
637905000581	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
637905000582	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
637905000583	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
637905000584	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
637905000585	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
637905000586	Cell division inhibitor SulA; Region: SulA; cl01880
637905000587	LexA repressor; Validated; Region: PRK00215
637905000588	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
637905000589	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
637905000590	Catalytic site [active]
637905000591	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
637905000592	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
637905000593	putative acyl-acceptor binding pocket; other site
637905000594	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
637905000595	aromatic amino acid transport protein; Region: araaP; TIGR00837
637905000596	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
637905000597	putative FMN binding site [chemical binding]; other site
637905000598	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
637905000599	Helix-turn-helix domain; Region: HTH_18; pfam12833
637905000600	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
637905000601	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
637905000602	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637905000603	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905000604	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905000605	metal binding site [ion binding]; metal-binding site
637905000606	active site
637905000607	I-site; other site
637905000608	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
637905000609	heme-binding site [chemical binding]; other site
637905000610	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
637905000611	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
637905000612	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
637905000613	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
637905000614	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
637905000615	B1 nucleotide binding pocket [chemical binding]; other site
637905000616	B2 nucleotide binding pocket [chemical binding]; other site
637905000617	CAS motifs; other site
637905000618	active site
637905000619	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
637905000620	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905000621	dimerization interface [polypeptide binding]; other site
637905000622	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905000623	dimer interface [polypeptide binding]; other site
637905000624	putative CheW interface [polypeptide binding]; other site
637905000625	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
637905000626	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
637905000627	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
637905000628	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905000629	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437
637905000630	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
637905000631	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905000632	S-adenosylmethionine binding site [chemical binding]; other site
637905000633	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
637905000634	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
637905000635	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
637905000636	P loop; other site
637905000637	GTP binding site [chemical binding]; other site
637905000638	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
637905000639	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637905000640	Walker A/P-loop; other site
637905000641	ATP binding site [chemical binding]; other site
637905000642	Q-loop/lid; other site
637905000643	ABC transporter signature motif; other site
637905000644	Walker B; other site
637905000645	D-loop; other site
637905000646	H-loop/switch region; other site
637905000647	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
637905000648	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
637905000649	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
637905000650	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
637905000651	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
637905000652	DNA binding residues [nucleotide binding]
637905000653	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
637905000654	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
637905000655	acyl-activating enzyme (AAE) consensus motif; other site
637905000656	putative AMP binding site [chemical binding]; other site
637905000657	putative active site [active]
637905000658	putative CoA binding site [chemical binding]; other site
637905000659	O-succinylbenzoate synthase; Provisional; Region: PRK05105
637905000660	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
637905000661	active site
637905000662	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
637905000663	Putative serine esterase (DUF676); Region: DUF676; pfam05057
637905000664	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
637905000665	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
637905000666	dimer interface [polypeptide binding]; other site
637905000667	tetramer interface [polypeptide binding]; other site
637905000668	PYR/PP interface [polypeptide binding]; other site
637905000669	TPP binding site [chemical binding]; other site
637905000670	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
637905000671	TPP-binding site; other site
637905000672	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
637905000673	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
637905000674	putative DNA binding site [nucleotide binding]; other site
637905000675	putative Zn2+ binding site [ion binding]; other site
637905000676	AsnC family; Region: AsnC_trans_reg; pfam01037
637905000677	putative transporter; Provisional; Region: PRK11021
637905000678	HDOD domain; Region: HDOD; pfam08668
637905000679	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
637905000680	putative metal binding site [ion binding]; other site
637905000681	Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075
637905000682	multidrug efflux protein; Reviewed; Region: PRK09577
637905000683	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
637905000684	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905000685	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
637905000686	substrate binding pocket [chemical binding]; other site
637905000687	dimerization interface [polypeptide binding]; other site
637905000688	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905000689	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
637905000690	putative substrate translocation pore; other site
637905000691	DTW domain; Region: DTW; cl01221
637905000692	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
637905000693	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
637905000694	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
637905000695	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
637905000696	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
637905000697	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
637905000698	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
637905000699	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
637905000700	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
637905000701	NADP binding site [chemical binding]; other site
637905000702	dimer interface [polypeptide binding]; other site
637905000703	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905000704	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905000705	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
637905000706	substrate binding pocket [chemical binding]; other site
637905000707	dimerization interface [polypeptide binding]; other site
637905000708	two-component sensor protein; Provisional; Region: cpxA; PRK09470
637905000709	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905000710	dimerization interface [polypeptide binding]; other site
637905000711	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905000712	ATP binding site [chemical binding]; other site
637905000713	Mg2+ binding site [ion binding]; other site
637905000714	G-X-G motif; other site
637905000715	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
637905000716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905000717	active site
637905000718	phosphorylation site [posttranslational modification]
637905000719	intermolecular recognition site; other site
637905000720	dimerization interface [polypeptide binding]; other site
637905000721	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637905000722	DNA binding site [nucleotide binding]
637905000723	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
637905000724	dimer interface [polypeptide binding]; other site
637905000725	Cation efflux family; Region: Cation_efflux; cl00316
637905000726	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
637905000727	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
637905000728	Paraquat-inducible protein A; Region: PqiA; pfam04403
637905000729	Paraquat-inducible protein A; Region: PqiA; pfam04403
637905000730	paraquat-inducible protein B; Provisional; Region: PRK10807
637905000731	mce related protein; Region: MCE; pfam02470
637905000732	mce related protein; Region: MCE; pfam02470
637905000733	mce related protein; Region: MCE; pfam02470
637905000734	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
637905000735	Protein of unknown function (DUF330); Region: DUF330; pfam03886
637905000736	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
637905000737	active site
637905000738	8-oxo-dGMP binding site [chemical binding]; other site
637905000739	nudix motif; other site
637905000740	metal binding site [ion binding]; metal-binding site
637905000741	Domain of unknown function (DUF329); Region: DUF329; pfam03884
637905000742	hypothetical protein; Provisional; Region: PRK05287
637905000743	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
637905000744	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
637905000745	CoA-binding site [chemical binding]; other site
637905000746	ATP-binding [chemical binding]; other site
637905000747	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
637905000748	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
637905000749	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
637905000750	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
637905000751	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
637905000752	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
637905000753	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
637905000754	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
637905000755	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
637905000756	Walker A motif; other site
637905000757	ATP binding site [chemical binding]; other site
637905000758	Walker B motif; other site
637905000759	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
637905000760	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
637905000761	dimerization interface [polypeptide binding]; other site
637905000762	active site
637905000763	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
637905000764	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
637905000765	amidase catalytic site [active]
637905000766	Zn binding residues [ion binding]; other site
637905000767	substrate binding site [chemical binding]; other site
637905000768	regulatory protein AmpE; Provisional; Region: PRK10987
637905000769	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
637905000770	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
637905000771	DNA-binding site [nucleotide binding]; DNA binding site
637905000772	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
637905000773	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
637905000774	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
637905000775	dimer interface [polypeptide binding]; other site
637905000776	TPP-binding site [chemical binding]; other site
637905000777	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
637905000778	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
637905000779	E3 interaction surface; other site
637905000780	lipoyl attachment site [posttranslational modification]; other site
637905000781	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
637905000782	E3 interaction surface; other site
637905000783	lipoyl attachment site [posttranslational modification]; other site
637905000784	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
637905000785	E3 interaction surface; other site
637905000786	lipoyl attachment site [posttranslational modification]; other site
637905000787	e3 binding domain; Region: E3_binding; pfam02817
637905000788	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
637905000789	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
637905000790	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
637905000791	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
637905000792	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
637905000793	PAS fold; Region: PAS_3; pfam08447
637905000794	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
637905000795	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
637905000796	PAS domain; Region: PAS_9; pfam13426
637905000797	putative active site [active]
637905000798	heme pocket [chemical binding]; other site
637905000799	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905000800	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905000801	metal binding site [ion binding]; metal-binding site
637905000802	active site
637905000803	I-site; other site
637905000804	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
637905000805	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
637905000806	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
637905000807	active site
637905000808	nucleophile elbow; other site
637905000809	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
637905000810	Surface antigen; Region: Bac_surface_Ag; pfam01103
637905000811	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
637905000812	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
637905000813	active site
637905000814	Zn binding site [ion binding]; other site
637905000815	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
637905000816	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
637905000817	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
637905000818	motif II; other site
637905000819	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
637905000820	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
637905000821	substrate binding site [chemical binding]; other site
637905000822	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
637905000823	substrate binding site [chemical binding]; other site
637905000824	ligand binding site [chemical binding]; other site
637905000825	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
637905000826	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
637905000827	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905000828	Walker A motif; other site
637905000829	ATP binding site [chemical binding]; other site
637905000830	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
637905000831	Walker B motif; other site
637905000832	arginine finger; other site
637905000833	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
637905000834	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
637905000835	active site
637905000836	HslU subunit interaction site [polypeptide binding]; other site
637905000837	Sporulation related domain; Region: SPOR; pfam05036
637905000838	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
637905000839	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
637905000840	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
637905000841	active site
637905000842	HIGH motif; other site
637905000843	KMSK motif region; other site
637905000844	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
637905000845	tRNA binding surface [nucleotide binding]; other site
637905000846	anticodon binding site; other site
637905000847	primosome assembly protein PriA; Validated; Region: PRK05580
637905000848	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637905000849	ATP binding site [chemical binding]; other site
637905000850	putative Mg++ binding site [ion binding]; other site
637905000851	helicase superfamily c-terminal domain; Region: HELICc; smart00490
637905000852	FimV N-terminal domain; Region: FimV_core; TIGR03505
637905000853	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
637905000854	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
637905000855	Malic enzyme, N-terminal domain; Region: malic; pfam00390
637905000856	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
637905000857	putative NAD(P) binding site [chemical binding]; other site
637905000858	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905000859	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905000860	metal binding site [ion binding]; metal-binding site
637905000861	active site
637905000862	I-site; other site
637905000863	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
637905000864	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
637905000865	Pilus assembly protein, PilO; Region: PilO; cl01234
637905000866	Secretin N-terminal domain; Region: Secretin_N_2; pfam07655
637905000867	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
637905000868	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
637905000869	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
637905000870	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905000871	Walker A motif; other site
637905000872	ATP binding site [chemical binding]; other site
637905000873	Walker B motif; other site
637905000874	arginine finger; other site
637905000875	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905000876	binding surface
637905000877	TPR motif; other site
637905000878	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905000879	binding surface
637905000880	TPR motif; other site
637905000881	TPR repeat; Region: TPR_11; pfam13414
637905000882	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
637905000883	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
637905000884	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
637905000885	Walker A motif; other site
637905000886	ATP binding site [chemical binding]; other site
637905000887	Walker B motif; other site
637905000888	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
637905000889	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
637905000890	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
637905000891	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
637905000892	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
637905000893	Verru_Chthon cassette protein C; Region: TIGR02599
637905000894	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
637905000895	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
637905000896	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
637905000897	rod shape-determining protein MreB; Provisional; Region: PRK13927
637905000898	MreB and similar proteins; Region: MreB_like; cd10225
637905000899	nucleotide binding site [chemical binding]; other site
637905000900	Mg binding site [ion binding]; other site
637905000901	putative protofilament interaction site [polypeptide binding]; other site
637905000902	RodZ interaction site [polypeptide binding]; other site
637905000903	rod shape-determining protein MreC; Region: mreC; TIGR00219
637905000904	rod shape-determining protein MreC; Region: MreC; pfam04085
637905000905	rod shape-determining protein MreD; Region: MreD; cl01087
637905000906	Maf-like protein; Region: Maf; pfam02545
637905000907	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
637905000908	active site
637905000909	dimer interface [polypeptide binding]; other site
637905000910	ribonuclease G; Provisional; Region: PRK11712
637905000911	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
637905000912	homodimer interface [polypeptide binding]; other site
637905000913	oligonucleotide binding site [chemical binding]; other site
637905000914	TIGR02099 family protein; Region: TIGR02099
637905000915	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
637905000916	nitrilase; Region: PLN02798
637905000917	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
637905000918	putative active site [active]
637905000919	catalytic triad [active]
637905000920	dimer interface [polypeptide binding]; other site
637905000921	protease TldD; Provisional; Region: tldD; PRK10735
637905000922	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
637905000923	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
637905000924	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637905000925	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905000926	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
637905000927	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
637905000928	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
637905000929	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
637905000930	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
637905000931	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
637905000932	hypothetical protein; Provisional; Region: PRK05255
637905000933	peptidase PmbA; Provisional; Region: PRK11040
637905000934	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
637905000935	dimerization interface [polypeptide binding]; other site
637905000936	putative DNA binding site [nucleotide binding]; other site
637905000937	putative Zn2+ binding site [ion binding]; other site
637905000938	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
637905000939	arsenical-resistance protein; Region: acr3; TIGR00832
637905000940	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
637905000941	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
637905000942	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
637905000943	Major Facilitator Superfamily; Region: MFS_1; pfam07690
637905000944	Major Facilitator Superfamily; Region: MFS_1; pfam07690
637905000945	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905000946	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
637905000947	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
637905000948	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
637905000949	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
637905000950	IHF dimer interface [polypeptide binding]; other site
637905000951	IHF - DNA interface [nucleotide binding]; other site
637905000952	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
637905000953	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905000954	active site
637905000955	phosphorylation site [posttranslational modification]
637905000956	intermolecular recognition site; other site
637905000957	dimerization interface [polypeptide binding]; other site
637905000958	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
637905000959	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905000960	active site
637905000961	phosphorylation site [posttranslational modification]
637905000962	intermolecular recognition site; other site
637905000963	dimerization interface [polypeptide binding]; other site
637905000964	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
637905000965	Protein of unknown function (DUF3016); Region: DUF3016; pfam11454
637905000966	TraB family; Region: TraB; pfam01963
637905000967	CheD chemotactic sensory transduction; Region: CheD; cl00810
637905000968	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
637905000969	active site 2 [active]
637905000970	active site 1 [active]
637905000971	formate--tetrahydrofolate ligase; Provisional; Region: PRK13506
637905000972	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
637905000973	Potassium binding sites [ion binding]; other site
637905000974	Cesium cation binding sites [ion binding]; other site
637905000975	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
637905000976	Mechanosensitive ion channel; Region: MS_channel; pfam00924
637905000977	Periplasmic binding protein TroA_c.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_c; cd01145
637905000978	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
637905000979	putative ligand binding site [chemical binding]; other site
637905000980	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
637905000981	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
637905000982	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
637905000983	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
637905000984	putative acyl-acceptor binding pocket; other site
637905000985	RNase E inhibitor protein; Provisional; Region: PRK11191
637905000986	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
637905000987	PAS fold; Region: PAS; pfam00989
637905000988	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905000989	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905000990	metal binding site [ion binding]; metal-binding site
637905000991	active site
637905000992	I-site; other site
637905000993	Response regulator receiver domain; Region: Response_reg; pfam00072
637905000994	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905000995	active site
637905000996	phosphorylation site [posttranslational modification]
637905000997	intermolecular recognition site; other site
637905000998	dimerization interface [polypeptide binding]; other site
637905000999	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
637905001000	enoyl-CoA hydratase; Provisional; Region: PRK07509
637905001001	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
637905001002	substrate binding site [chemical binding]; other site
637905001003	oxyanion hole (OAH) forming residues; other site
637905001004	trimer interface [polypeptide binding]; other site
637905001005	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
637905001006	ATP-dependent helicase HepA; Validated; Region: PRK04914
637905001007	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637905001008	ATP binding site [chemical binding]; other site
637905001009	putative Mg++ binding site [ion binding]; other site
637905001010	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905001011	nucleotide binding region [chemical binding]; other site
637905001012	ATP-binding site [chemical binding]; other site
637905001013	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
637905001014	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
637905001015	putative active site [active]
637905001016	PhoH-like protein; Region: PhoH; pfam02562
637905001017	Cache domain; Region: Cache_1; pfam02743
637905001018	PAS fold; Region: PAS_4; pfam08448
637905001019	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
637905001020	putative active site [active]
637905001021	heme pocket [chemical binding]; other site
637905001022	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
637905001023	PAS fold; Region: PAS_3; pfam08447
637905001024	putative active site [active]
637905001025	heme pocket [chemical binding]; other site
637905001026	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
637905001027	dimer interface [polypeptide binding]; other site
637905001028	phosphorylation site [posttranslational modification]
637905001029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905001030	ATP binding site [chemical binding]; other site
637905001031	Mg2+ binding site [ion binding]; other site
637905001032	G-X-G motif; other site
637905001033	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905001034	Response regulator receiver domain; Region: Response_reg; pfam00072
637905001035	active site
637905001036	phosphorylation site [posttranslational modification]
637905001037	intermolecular recognition site; other site
637905001038	dimerization interface [polypeptide binding]; other site
637905001039	Response regulator receiver domain; Region: Response_reg; pfam00072
637905001040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905001041	active site
637905001042	phosphorylation site [posttranslational modification]
637905001043	intermolecular recognition site; other site
637905001044	dimerization interface [polypeptide binding]; other site
637905001045	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
637905001046	active site
637905001047	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
637905001048	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
637905001049	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637905001050	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905001051	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905001052	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905001053	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
637905001054	putative effector binding pocket; other site
637905001055	dimerization interface [polypeptide binding]; other site
637905001056	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
637905001057	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
637905001058	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
637905001059	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
637905001060	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
637905001061	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
637905001062	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
637905001063	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
637905001064	oligomerisation interface [polypeptide binding]; other site
637905001065	mobile loop; other site
637905001066	roof hairpin; other site
637905001067	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
637905001068	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
637905001069	ring oligomerisation interface [polypeptide binding]; other site
637905001070	ATP/Mg binding site [chemical binding]; other site
637905001071	stacking interactions; other site
637905001072	hinge regions; other site
637905001073	Nuclease-related domain; Region: NERD; pfam08378
637905001074	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
637905001075	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
637905001076	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
637905001077	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
637905001078	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
637905001079	TrkA-N domain; Region: TrkA_N; pfam02254
637905001080	TrkA-C domain; Region: TrkA_C; pfam02080
637905001081	Protein of unknown function (DUF2999); Region: DUF2999; pfam11212
637905001082	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
637905001083	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
637905001084	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
637905001085	substrate binding site [chemical binding]; other site
637905001086	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
637905001087	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
637905001088	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
637905001089	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
637905001090	MarR family; Region: MarR; pfam01047
637905001091	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
637905001092	active site residue [active]
637905001093	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
637905001094	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
637905001095	NAD binding site [chemical binding]; other site
637905001096	active site
637905001097	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
637905001098	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
637905001099	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
637905001100	putative active site [active]
637905001101	putative metal binding site [ion binding]; other site
637905001102	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
637905001103	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
637905001104	putative acyl-acceptor binding pocket; other site
637905001105	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
637905001106	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
637905001107	Penicillinase repressor; Region: Pencillinase_R; cl17580
637905001108	fumarate hydratase; Reviewed; Region: fumC; PRK00485
637905001109	Class II fumarases; Region: Fumarase_classII; cd01362
637905001110	active site
637905001111	tetramer interface [polypeptide binding]; other site
637905001112	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
637905001113	active site
637905001114	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
637905001115	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
637905001116	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
637905001117	putative RNA binding site [nucleotide binding]; other site
637905001118	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905001119	S-adenosylmethionine binding site [chemical binding]; other site
637905001120	PGAP1-like protein; Region: PGAP1; pfam07819
637905001121	potential frameshift: common BLAST hit: gi|256821608|ref|YP_003145571.1| protein of unknown function DUF885
637905001122	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
637905001123	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
637905001124	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
637905001125	Family description; Region: VCBS; pfam13517
637905001126	Family description; Region: VCBS; pfam13517
637905001127	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
637905001128	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
637905001129	dimer interface [polypeptide binding]; other site
637905001130	phosphorylation site [posttranslational modification]
637905001131	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
637905001132	ATP binding site [chemical binding]; other site
637905001133	G-X-G motif; other site
637905001134	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
637905001135	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905001136	active site
637905001137	phosphorylation site [posttranslational modification]
637905001138	intermolecular recognition site; other site
637905001139	dimerization interface [polypeptide binding]; other site
637905001140	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637905001141	DNA binding site [nucleotide binding]
637905001142	putative outer membrane lipoprotein; Provisional; Region: PRK10510
637905001143	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
637905001144	ligand binding site [chemical binding]; other site
637905001145	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
637905001146	MgtE intracellular N domain; Region: MgtE_N; smart00924
637905001147	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
637905001148	Divalent cation transporter; Region: MgtE; pfam01769
637905001149	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
637905001150	dimerization domain swap beta strand [polypeptide binding]; other site
637905001151	regulatory protein interface [polypeptide binding]; other site
637905001152	active site
637905001153	regulatory phosphorylation site [posttranslational modification]; other site
637905001154	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
637905001155	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
637905001156	active site
637905001157	phosphorylation site [posttranslational modification]
637905001158	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
637905001159	30S subunit binding site; other site
637905001160	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
637905001161	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
637905001162	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
637905001163	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
637905001164	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
637905001165	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
637905001166	Walker A/P-loop; other site
637905001167	ATP binding site [chemical binding]; other site
637905001168	Q-loop/lid; other site
637905001169	ABC transporter signature motif; other site
637905001170	Walker B; other site
637905001171	D-loop; other site
637905001172	H-loop/switch region; other site
637905001173	OstA-like protein; Region: OstA; cl00844
637905001174	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
637905001175	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
637905001176	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
637905001177	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
637905001178	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
637905001179	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
637905001180	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
637905001181	putative active site [active]
637905001182	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
637905001183	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
637905001184	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
637905001185	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
637905001186	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
637905001187	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
637905001188	Walker A/P-loop; other site
637905001189	ATP binding site [chemical binding]; other site
637905001190	Q-loop/lid; other site
637905001191	ABC transporter signature motif; other site
637905001192	Walker B; other site
637905001193	D-loop; other site
637905001194	H-loop/switch region; other site
637905001195	conserved hypothetical integral membrane protein; Region: TIGR00056
637905001196	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
637905001197	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
637905001198	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
637905001199	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
637905001200	anti sigma factor interaction site; other site
637905001201	regulatory phosphorylation site [posttranslational modification]; other site
637905001202	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
637905001203	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
637905001204	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
637905001205	hinge; other site
637905001206	active site
637905001207	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
637905001208	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
637905001209	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
637905001210	protein binding site [polypeptide binding]; other site
637905001211	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
637905001212	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
637905001213	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
637905001214	protein binding site [polypeptide binding]; other site
637905001215	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
637905001216	Protein of unknown function (DUF1043); Region: DUF1043; cl11473
637905001217	Predicted ATPase [General function prediction only]; Region: COG1485
637905001218	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
637905001219	23S rRNA interface [nucleotide binding]; other site
637905001220	L3 interface [polypeptide binding]; other site
637905001221	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
637905001222	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
637905001223	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
637905001224	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
637905001225	GDP-binding site [chemical binding]; other site
637905001226	ACT binding site; other site
637905001227	IMP binding site; other site
637905001228	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
637905001229	Sel1 repeat; Region: Sel1; cl02723
637905001230	ribonuclease R; Region: RNase_R; TIGR02063
637905001231	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
637905001232	RNB domain; Region: RNB; pfam00773
637905001233	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
637905001234	RNA binding site [nucleotide binding]; other site
637905001235	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
637905001236	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
637905001237	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
637905001238	Protein of unknown function, DUF481; Region: DUF481; pfam04338
637905001239	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
637905001240	primosomal replication protein N; Provisional; Region: PRK02801
637905001241	generic binding surface II; other site
637905001242	generic binding surface I; other site
637905001243	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
637905001244	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
637905001245	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
637905001246	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
637905001247	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
637905001248	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
637905001249	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905001250	Peptidase S46; Region: Peptidase_S46; pfam10459
637905001251	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
637905001252	replicative DNA helicase; Provisional; Region: PRK08840
637905001253	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
637905001254	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
637905001255	Walker A motif; other site
637905001256	ATP binding site [chemical binding]; other site
637905001257	Walker B motif; other site
637905001258	DNA binding loops [nucleotide binding]
637905001259	alanine racemase; Reviewed; Region: alr; PRK00053
637905001260	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
637905001261	active site
637905001262	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
637905001263	substrate binding site [chemical binding]; other site
637905001264	catalytic residues [active]
637905001265	dimer interface [polypeptide binding]; other site
637905001266	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
637905001267	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
637905001268	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
637905001269	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
637905001270	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
637905001271	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
637905001272	FMN binding site [chemical binding]; other site
637905001273	active site
637905001274	catalytic residues [active]
637905001275	substrate binding site [chemical binding]; other site
637905001276	PspC domain; Region: PspC; pfam04024
637905001277	enoyl-CoA hydratase; Provisional; Region: PRK06688
637905001278	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
637905001279	substrate binding site [chemical binding]; other site
637905001280	oxyanion hole (OAH) forming residues; other site
637905001281	trimer interface [polypeptide binding]; other site
637905001282	Protein of unknown function (DUF461); Region: DUF461; pfam04314
637905001283	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095
637905001284	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
637905001285	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
637905001286	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
637905001287	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
637905001288	dimer interface [polypeptide binding]; other site
637905001289	ADP-ribose binding site [chemical binding]; other site
637905001290	active site
637905001291	nudix motif; other site
637905001292	metal binding site [ion binding]; metal-binding site
637905001293	Protein of unknown function (DUF1249); Region: DUF1249; pfam06853
637905001294	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
637905001295	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
637905001296	active site
637905001297	metal binding site [ion binding]; metal-binding site
637905001298	hexamer interface [polypeptide binding]; other site
637905001299	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
637905001300	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
637905001301	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
637905001302	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905001303	ATP binding site [chemical binding]; other site
637905001304	Mg2+ binding site [ion binding]; other site
637905001305	G-X-G motif; other site
637905001306	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
637905001307	anchoring element; other site
637905001308	dimer interface [polypeptide binding]; other site
637905001309	ATP binding site [chemical binding]; other site
637905001310	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
637905001311	active site
637905001312	metal binding site [ion binding]; metal-binding site
637905001313	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
637905001314	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
637905001315	SdiA-regulated; Region: SdiA-regulated; cd09971
637905001316	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
637905001317	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
637905001318	CAP-like domain; other site
637905001319	active site
637905001320	primary dimer interface [polypeptide binding]; other site
637905001321	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
637905001322	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
637905001323	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
637905001324	NAD binding site [chemical binding]; other site
637905001325	ligand binding site [chemical binding]; other site
637905001326	catalytic site [active]
637905001327	Protein of unknown function (DUF3392); Region: DUF3392; pfam11872
637905001328	putative mechanosensitive channel protein; Provisional; Region: PRK10929
637905001329	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
637905001330	Mechanosensitive ion channel; Region: MS_channel; pfam00924
637905001331	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
637905001332	EamA-like transporter family; Region: EamA; pfam00892
637905001333	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
637905001334	GTPase RsgA; Reviewed; Region: PRK12288
637905001335	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
637905001336	RNA binding site [nucleotide binding]; other site
637905001337	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
637905001338	GTPase/Zn-binding domain interface [polypeptide binding]; other site
637905001339	GTP/Mg2+ binding site [chemical binding]; other site
637905001340	G4 box; other site
637905001341	G5 box; other site
637905001342	G1 box; other site
637905001343	Switch I region; other site
637905001344	G2 box; other site
637905001345	G3 box; other site
637905001346	Switch II region; other site
637905001347	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
637905001348	catalytic site [active]
637905001349	putative active site [active]
637905001350	putative substrate binding site [chemical binding]; other site
637905001351	dimer interface [polypeptide binding]; other site
637905001352	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
637905001353	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
637905001354	AMIN domain; Region: AMIN; pfam11741
637905001355	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
637905001356	active site
637905001357	metal binding site [ion binding]; metal-binding site
637905001358	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
637905001359	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
637905001360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905001361	Mg2+ binding site [ion binding]; other site
637905001362	G-X-G motif; other site
637905001363	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
637905001364	ATP binding site [chemical binding]; other site
637905001365	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
637905001366	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
637905001367	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
637905001368	bacterial Hfq-like; Region: Hfq; cd01716
637905001369	hexamer interface [polypeptide binding]; other site
637905001370	Sm1 motif; other site
637905001371	RNA binding site [nucleotide binding]; other site
637905001372	Sm2 motif; other site
637905001373	GTPase HflX; Provisional; Region: PRK11058
637905001374	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
637905001375	HflX GTPase family; Region: HflX; cd01878
637905001376	G1 box; other site
637905001377	GTP/Mg2+ binding site [chemical binding]; other site
637905001378	Switch I region; other site
637905001379	G2 box; other site
637905001380	G3 box; other site
637905001381	Switch II region; other site
637905001382	G4 box; other site
637905001383	G5 box; other site
637905001384	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
637905001385	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
637905001386	HflK protein; Region: hflK; TIGR01933
637905001387	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
637905001388	FtsH protease regulator HflC; Provisional; Region: PRK11029
637905001389	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
637905001390	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
637905001391	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
637905001392	[2Fe-2S] cluster binding site [ion binding]; other site
637905001393	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
637905001394	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
637905001395	Qi binding site; other site
637905001396	intrachain domain interface; other site
637905001397	interchain domain interface [polypeptide binding]; other site
637905001398	heme bH binding site [chemical binding]; other site
637905001399	heme bL binding site [chemical binding]; other site
637905001400	Qo binding site; other site
637905001401	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
637905001402	interchain domain interface [polypeptide binding]; other site
637905001403	intrachain domain interface; other site
637905001404	Qi binding site; other site
637905001405	Qo binding site; other site
637905001406	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
637905001407	stringent starvation protein A; Provisional; Region: sspA; PRK09481
637905001408	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
637905001409	C-terminal domain interface [polypeptide binding]; other site
637905001410	putative GSH binding site (G-site) [chemical binding]; other site
637905001411	dimer interface [polypeptide binding]; other site
637905001412	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
637905001413	dimer interface [polypeptide binding]; other site
637905001414	N-terminal domain interface [polypeptide binding]; other site
637905001415	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
637905001416	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
637905001417	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
637905001418	glutamine binding [chemical binding]; other site
637905001419	catalytic triad [active]
637905001420	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
637905001421	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
637905001422	HDOD domain; Region: HDOD; pfam08668
637905001423	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
637905001424	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
637905001425	inhibitor-cofactor binding pocket; inhibition site
637905001426	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905001427	catalytic residue [active]
637905001428	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
637905001429	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
637905001430	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
637905001431	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
637905001432	NAD(P) binding site [chemical binding]; other site
637905001433	catalytic residues [active]
637905001434	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
637905001435	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
637905001436	HAMP domain; Region: HAMP; pfam00672
637905001437	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
637905001438	dimer interface [polypeptide binding]; other site
637905001439	phosphorylation site [posttranslational modification]
637905001440	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905001441	ATP binding site [chemical binding]; other site
637905001442	Mg2+ binding site [ion binding]; other site
637905001443	G-X-G motif; other site
637905001444	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
637905001445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905001446	active site
637905001447	phosphorylation site [posttranslational modification]
637905001448	intermolecular recognition site; other site
637905001449	dimerization interface [polypeptide binding]; other site
637905001450	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637905001451	DNA binding site [nucleotide binding]
637905001452	Predicted membrane protein [Function unknown]; Region: COG3212
637905001453	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
637905001454	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
637905001455	ligand binding site [chemical binding]; other site
637905001456	flexible hinge region; other site
637905001457	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
637905001458	putative switch regulator; other site
637905001459	non-specific DNA interactions [nucleotide binding]; other site
637905001460	DNA binding site [nucleotide binding]
637905001461	sequence specific DNA binding site [nucleotide binding]; other site
637905001462	putative cAMP binding site [chemical binding]; other site
637905001463	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
637905001464	Sel1-like repeats; Region: SEL1; smart00671
637905001465	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
637905001466	binding surface
637905001467	TPR motif; other site
637905001468	phosphoribulokinase; Provisional; Region: PRK15453
637905001469	active site
637905001470	Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180
637905001471	putative hydrolase; Provisional; Region: PRK10985
637905001472	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
637905001473	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
637905001474	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
637905001475	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
637905001476	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
637905001477	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
637905001478	ABC transporter; Region: ABC_tran_2; pfam12848
637905001479	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
637905001480	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
637905001481	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
637905001482	non-specific DNA binding site [nucleotide binding]; other site
637905001483	salt bridge; other site
637905001484	sequence-specific DNA binding site [nucleotide binding]; other site
637905001485	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
637905001486	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
637905001487	ATP binding site [chemical binding]; other site
637905001488	Mg++ binding site [ion binding]; other site
637905001489	motif III; other site
637905001490	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905001491	nucleotide binding region [chemical binding]; other site
637905001492	ATP-binding site [chemical binding]; other site
637905001493	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
637905001494	putative RNA binding site [nucleotide binding]; other site
637905001495	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
637905001496	DEAD-like helicases superfamily; Region: DEXDc; smart00487
637905001497	ATP binding site [chemical binding]; other site
637905001498	Mg++ binding site [ion binding]; other site
637905001499	motif III; other site
637905001500	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905001501	nucleotide binding region [chemical binding]; other site
637905001502	ATP-binding site [chemical binding]; other site
637905001503	Protein of unknown function (DUF3565); Region: DUF3565; pfam12088
637905001504	Protein of unknown function (DUF3622); Region: DUF3622; pfam12286
637905001505	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
637905001506	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
637905001507	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
637905001508	Walker A/P-loop; other site
637905001509	ATP binding site [chemical binding]; other site
637905001510	Q-loop/lid; other site
637905001511	ABC transporter signature motif; other site
637905001512	Walker B; other site
637905001513	D-loop; other site
637905001514	H-loop/switch region; other site
637905001515	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
637905001516	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637905001517	Walker A/P-loop; other site
637905001518	ATP binding site [chemical binding]; other site
637905001519	Q-loop/lid; other site
637905001520	ABC transporter signature motif; other site
637905001521	Walker B; other site
637905001522	D-loop; other site
637905001523	H-loop/switch region; other site
637905001524	Helix-turn-helix domain; Region: HTH_17; pfam12728
637905001525	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
637905001526	Proline dehydrogenase; Region: Pro_dh; pfam01619
637905001527	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
637905001528	Glutamate binding site [chemical binding]; other site
637905001529	NAD binding site [chemical binding]; other site
637905001530	catalytic residues [active]
637905001531	Bacterial SH3 domain homologues; Region: SH3b; smart00287
637905001532	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
637905001533	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
637905001534	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
637905001535	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
637905001536	Uncharacterized conserved protein [Function unknown]; Region: COG3025
637905001537	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
637905001538	putative active site [active]
637905001539	putative triphosphate binding site [ion binding]; other site
637905001540	putative metal binding residues [ion binding]; other site
637905001541	Ion transport protein; Region: Ion_trans; pfam00520
637905001542	Ion channel; Region: Ion_trans_2; pfam07885
637905001543	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
637905001544	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938
637905001545	spermidine synthase; Provisional; Region: PRK03612
637905001546	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905001547	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
637905001548	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
637905001549	metal binding triad; other site
637905001550	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
637905001551	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
637905001552	metal binding triad; other site
637905001553	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
637905001554	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
637905001555	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
637905001556	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
637905001557	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
637905001558	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
637905001559	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
637905001560	LysR family transcriptional regulator; Provisional; Region: PRK14997
637905001561	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905001562	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
637905001563	putative effector binding pocket; other site
637905001564	dimerization interface [polypeptide binding]; other site
637905001565	Pirin; Region: Pirin; pfam02678
637905001566	Isochorismatase family; Region: Isochorismatase; pfam00857
637905001567	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
637905001568	catalytic triad [active]
637905001569	dimer interface [polypeptide binding]; other site
637905001570	conserved cis-peptide bond; other site
637905001571	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
637905001572	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
637905001573	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905001574	dimerization interface [polypeptide binding]; other site
637905001575	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905001576	dimer interface [polypeptide binding]; other site
637905001577	putative CheW interface [polypeptide binding]; other site
637905001578	Predicted ATPase [General function prediction only]; Region: COG1485
637905001579	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
637905001580	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
637905001581	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
637905001582	ligand binding site [chemical binding]; other site
637905001583	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
637905001584	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
637905001585	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
637905001586	DNA binding residues [nucleotide binding]
637905001587	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
637905001588	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
637905001589	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
637905001590	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
637905001591	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
637905001592	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
637905001593	putative acyl-acceptor binding pocket; other site
637905001594	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
637905001595	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
637905001596	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
637905001597	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
637905001598	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
637905001599	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
637905001600	MltA-interacting protein MipA; Region: MipA; cl01504
637905001601	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
637905001602	Flavodoxin; Region: Flavodoxin_1; pfam00258
637905001603	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
637905001604	FAD binding pocket [chemical binding]; other site
637905001605	FAD binding motif [chemical binding]; other site
637905001606	catalytic residues [active]
637905001607	NAD binding pocket [chemical binding]; other site
637905001608	phosphate binding motif [ion binding]; other site
637905001609	beta-alpha-beta structure motif; other site
637905001610	sulfite reductase subunit beta; Provisional; Region: PRK13504
637905001611	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
637905001612	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
637905001613	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
637905001614	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
637905001615	Active Sites [active]
637905001616	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
637905001617	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
637905001618	Protein of unknown function (DUF3010); Region: DUF3010; pfam11215
637905001619	Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718
637905001620	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
637905001621	ATP binding site [chemical binding]; other site
637905001622	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
637905001623	catalytic triad [active]
637905001624	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
637905001625	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248
637905001626	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248
637905001627	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
637905001628	active site
637905001629	SAM binding site [chemical binding]; other site
637905001630	homodimer interface [polypeptide binding]; other site
637905001631	TIGR03899 family protein; Region: TIGR03899
637905001632	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905001633	Major Facilitator Superfamily; Region: MFS_1; pfam07690
637905001634	putative substrate translocation pore; other site
637905001635	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
637905001636	Imelysin; Region: Peptidase_M75; pfam09375
637905001637	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
637905001638	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
637905001639	CHASE domain; Region: CHASE; pfam03924
637905001640	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905001641	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905001642	metal binding site [ion binding]; metal-binding site
637905001643	active site
637905001644	I-site; other site
637905001645	CHASE domain; Region: CHASE; pfam03924
637905001646	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905001647	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905001648	metal binding site [ion binding]; metal-binding site
637905001649	active site
637905001650	I-site; other site
637905001651	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
637905001652	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
637905001653	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
637905001654	putative metal binding site [ion binding]; other site
637905001655	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
637905001656	putative catalytic site [active]
637905001657	putative phosphate binding site [ion binding]; other site
637905001658	putative metal binding site [ion binding]; other site
637905001659	Fusaric acid resistance protein family; Region: FUSC; pfam04632
637905001660	Fusaric acid resistance protein family; Region: FUSC; pfam04632
637905001661	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
637905001662	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
637905001663	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
637905001664	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637905001665	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905001666	Ion channel; Region: Ion_trans_2; pfam07885
637905001667	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
637905001668	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
637905001669	DNA-binding site [nucleotide binding]; DNA binding site
637905001670	RNA-binding motif; other site
637905001671	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
637905001672	EamA-like transporter family; Region: EamA; pfam00892
637905001673	Domain of unknown function; Region: DUF331; pfam03889
637905001674	hypothetical protein; Validated; Region: PRK00029
637905001675	Uncharacterized conserved protein [Function unknown]; Region: COG0397
637905001676	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
637905001677	ABC-2 type transporter; Region: ABC2_membrane; cl17235
637905001678	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
637905001679	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
637905001680	Walker A/P-loop; other site
637905001681	ATP binding site [chemical binding]; other site
637905001682	Q-loop/lid; other site
637905001683	ABC transporter signature motif; other site
637905001684	Walker B; other site
637905001685	D-loop; other site
637905001686	H-loop/switch region; other site
637905001687	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
637905001688	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
637905001689	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
637905001690	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
637905001691	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
637905001692	active site
637905001693	homodimer interface [polypeptide binding]; other site
637905001694	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
637905001695	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
637905001696	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
637905001697	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
637905001698	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
637905001699	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
637905001700	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
637905001701	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
637905001702	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
637905001703	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
637905001704	active site
637905001705	substrate binding site [chemical binding]; other site
637905001706	metal binding site [ion binding]; metal-binding site
637905001707	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
637905001708	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
637905001709	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
637905001710	Ligand binding site; other site
637905001711	oligomer interface; other site
637905001712	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563
637905001713	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
637905001714	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
637905001715	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
637905001716	D-ribose pyranase; Provisional; Region: PRK11797
637905001717	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
637905001718	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
637905001719	Walker A/P-loop; other site
637905001720	ATP binding site [chemical binding]; other site
637905001721	Q-loop/lid; other site
637905001722	ABC transporter signature motif; other site
637905001723	Walker B; other site
637905001724	D-loop; other site
637905001725	H-loop/switch region; other site
637905001726	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
637905001727	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
637905001728	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
637905001729	TM-ABC transporter signature motif; other site
637905001730	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
637905001731	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
637905001732	ligand binding site [chemical binding]; other site
637905001733	dimerization interface [polypeptide binding]; other site
637905001734	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
637905001735	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
637905001736	substrate binding site [chemical binding]; other site
637905001737	dimer interface [polypeptide binding]; other site
637905001738	ATP binding site [chemical binding]; other site
637905001739	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
637905001740	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
637905001741	DNA binding site [nucleotide binding]
637905001742	domain linker motif; other site
637905001743	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
637905001744	dimerization interface [polypeptide binding]; other site
637905001745	ligand binding site [chemical binding]; other site
637905001746	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
637905001747	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
637905001748	putative active site [active]
637905001749	Zn binding site [ion binding]; other site
637905001750	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
637905001751	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
637905001752	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
637905001753	active site
637905001754	Zn binding site [ion binding]; other site
637905001755	UPF0506; Region: UPF0506; pfam11703
637905001756	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
637905001757	Domain of unknown function (DUF3332); Region: DUF3332; pfam11810
637905001758	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
637905001759	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
637905001760	PII uridylyl-transferase; Provisional; Region: PRK05007
637905001761	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
637905001762	metal binding triad; other site
637905001763	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
637905001764	HD domain; Region: HD; pfam01966
637905001765	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
637905001766	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
637905001767	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
637905001768	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
637905001769	HAMP domain; Region: HAMP; pfam00672
637905001770	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905001771	dimer interface [polypeptide binding]; other site
637905001772	putative CheW interface [polypeptide binding]; other site
637905001773	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
637905001774	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
637905001775	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905001776	dimer interface [polypeptide binding]; other site
637905001777	putative CheW interface [polypeptide binding]; other site
637905001778	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
637905001779	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905001780	N-terminal plug; other site
637905001781	ligand-binding site [chemical binding]; other site
637905001782	Protein of unknown function (DUF465); Region: DUF465; pfam04325
637905001783	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
637905001784	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
637905001785	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
637905001786	substrate binding pocket [chemical binding]; other site
637905001787	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
637905001788	B12 binding site [chemical binding]; other site
637905001789	cobalt ligand [ion binding]; other site
637905001790	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
637905001791	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
637905001792	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
637905001793	Na binding site [ion binding]; other site
637905001794	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
637905001795	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905001796	ATP binding site [chemical binding]; other site
637905001797	Mg2+ binding site [ion binding]; other site
637905001798	G-X-G motif; other site
637905001799	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
637905001800	catalytic core [active]
637905001801	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
637905001802	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
637905001803	Walker A/P-loop; other site
637905001804	ATP binding site [chemical binding]; other site
637905001805	Q-loop/lid; other site
637905001806	ABC transporter signature motif; other site
637905001807	Walker B; other site
637905001808	D-loop; other site
637905001809	H-loop/switch region; other site
637905001810	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
637905001811	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
637905001812	ABC-ATPase subunit  interface; other site
637905001813	dimer interface [polypeptide binding]; other site
637905001814	putative PBP binding regions; other site
637905001815	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
637905001816	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
637905001817	putative dimer interface [polypeptide binding]; other site
637905001818	active site pocket [active]
637905001819	putative cataytic base [active]
637905001820	cobalamin synthase; Reviewed; Region: cobS; PRK00235
637905001821	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
637905001822	cobyric acid synthase; Provisional; Region: PRK00784
637905001823	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
637905001824	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
637905001825	catalytic triad [active]
637905001826	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
637905001827	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
637905001828	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
637905001829	homodimer interface [polypeptide binding]; other site
637905001830	Walker A motif; other site
637905001831	ATP binding site [chemical binding]; other site
637905001832	hydroxycobalamin binding site [chemical binding]; other site
637905001833	Walker B motif; other site
637905001834	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
637905001835	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
637905001836	cobalamin binding residues [chemical binding]; other site
637905001837	putative BtuC binding residues; other site
637905001838	dimer interface [polypeptide binding]; other site
637905001839	MAPEG family; Region: MAPEG; cl09190
637905001840	Predicted transporter component [General function prediction only]; Region: COG2391
637905001841	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
637905001842	Predicted transporter component [General function prediction only]; Region: COG2391
637905001843	Sulphur transport; Region: Sulf_transp; pfam04143
637905001844	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
637905001845	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905001846	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
637905001847	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
637905001848	Walker A/P-loop; other site
637905001849	ATP binding site [chemical binding]; other site
637905001850	Q-loop/lid; other site
637905001851	ABC transporter signature motif; other site
637905001852	Walker B; other site
637905001853	D-loop; other site
637905001854	H-loop/switch region; other site
637905001855	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
637905001856	FtsX-like permease family; Region: FtsX; pfam02687
637905001857	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
637905001858	FtsX-like permease family; Region: FtsX; pfam02687
637905001859	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
637905001860	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905001861	active site
637905001862	phosphorylation site [posttranslational modification]
637905001863	intermolecular recognition site; other site
637905001864	dimerization interface [polypeptide binding]; other site
637905001865	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905001866	Walker A motif; other site
637905001867	ATP binding site [chemical binding]; other site
637905001868	Walker B motif; other site
637905001869	arginine finger; other site
637905001870	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
637905001871	PAS domain; Region: PAS_8; pfam13188
637905001872	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
637905001873	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905001874	ATP binding site [chemical binding]; other site
637905001875	Mg2+ binding site [ion binding]; other site
637905001876	G-X-G motif; other site
637905001877	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
637905001878	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
637905001879	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
637905001880	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
637905001881	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
637905001882	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
637905001883	active site
637905001884	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
637905001885	Predicted membrane protein [Function unknown]; Region: COG3428
637905001886	Bacterial PH domain; Region: DUF304; pfam03703
637905001887	Bacterial PH domain; Region: DUF304; pfam03703
637905001888	Uncharacterized conserved protein [Function unknown]; Region: COG3402
637905001889	Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; pfam09904
637905001890	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
637905001891	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
637905001892	heme-binding site [chemical binding]; other site
637905001893	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
637905001894	FAD binding pocket [chemical binding]; other site
637905001895	FAD binding motif [chemical binding]; other site
637905001896	phosphate binding motif [ion binding]; other site
637905001897	beta-alpha-beta structure motif; other site
637905001898	NAD binding pocket [chemical binding]; other site
637905001899	Heme binding  pocket [chemical binding]; other site
637905001900	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
637905001901	GAF domain; Region: GAF; pfam01590
637905001902	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905001903	Walker A motif; other site
637905001904	ATP binding site [chemical binding]; other site
637905001905	Walker B motif; other site
637905001906	arginine finger; other site
637905001907	nif11 domain/cupin domain protein; Region: nif11_cupin; TIGR03890
637905001908	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
637905001909	pentamer interface [polypeptide binding]; other site
637905001910	dodecaamer interface [polypeptide binding]; other site
637905001911	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
637905001912	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
637905001913	active site
637905001914	metal binding site [ion binding]; metal-binding site
637905001915	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
637905001916	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
637905001917	DctM-like transporters; Region: DctM; pfam06808
637905001918	AAA domain; Region: AAA_17; pfam13207
637905001919	methionine aminotransferase; Validated; Region: PRK09082
637905001920	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
637905001921	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905001922	homodimer interface [polypeptide binding]; other site
637905001923	catalytic residue [active]
637905001924	Fe-S metabolism associated domain; Region: SufE; cl00951
637905001925	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
637905001926	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
637905001927	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
637905001928	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
637905001929	catalytic residue [active]
637905001930	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905001931	S-adenosylmethionine binding site [chemical binding]; other site
637905001932	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
637905001933	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
637905001934	active site
637905001935	catalytic tetrad [active]
637905001936	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
637905001937	MarR family; Region: MarR_2; pfam12802
637905001938	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637905001939	Coenzyme A binding pocket [chemical binding]; other site
637905001940	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
637905001941	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
637905001942	serine transporter; Region: stp; TIGR00814
637905001943	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
637905001944	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
637905001945	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
637905001946	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
637905001947	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
637905001948	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637905001949	Coenzyme A binding pocket [chemical binding]; other site
637905001950	META domain; Region: META; pfam03724
637905001951	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905001952	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905001953	metal binding site [ion binding]; metal-binding site
637905001954	active site
637905001955	I-site; other site
637905001956	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905001957	S-adenosylmethionine synthetase; Validated; Region: PRK05250
637905001958	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
637905001959	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
637905001960	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
637905001961	transketolase; Reviewed; Region: PRK12753
637905001962	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
637905001963	TPP-binding site [chemical binding]; other site
637905001964	dimer interface [polypeptide binding]; other site
637905001965	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
637905001966	PYR/PP interface [polypeptide binding]; other site
637905001967	dimer interface [polypeptide binding]; other site
637905001968	TPP binding site [chemical binding]; other site
637905001969	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
637905001970	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
637905001971	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
637905001972	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
637905001973	Phosphoglycerate kinase; Region: PGK; pfam00162
637905001974	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
637905001975	substrate binding site [chemical binding]; other site
637905001976	hinge regions; other site
637905001977	ADP binding site [chemical binding]; other site
637905001978	catalytic site [active]
637905001979	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
637905001980	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
637905001981	intersubunit interface [polypeptide binding]; other site
637905001982	active site
637905001983	zinc binding site [ion binding]; other site
637905001984	Na+ binding site [ion binding]; other site
637905001985	Protein of unknown function, DUF481; Region: DUF481; pfam04338
637905001986	PAS domain; Region: PAS_9; pfam13426
637905001987	PAS domain; Region: PAS_9; pfam13426
637905001988	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905001989	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
637905001990	Protein export membrane protein; Region: SecD_SecF; cl14618
637905001991	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
637905001992	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905001993	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
637905001994	DEAD-like helicases superfamily; Region: DEXDc; smart00487
637905001995	ATP binding site [chemical binding]; other site
637905001996	Mg++ binding site [ion binding]; other site
637905001997	motif III; other site
637905001998	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905001999	nucleotide binding region [chemical binding]; other site
637905002000	ATP-binding site [chemical binding]; other site
637905002001	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
637905002002	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905002003	S-adenosylmethionine binding site [chemical binding]; other site
637905002004	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
637905002005	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
637905002006	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
637905002007	active site
637905002008	Int/Topo IB signature motif; other site
637905002009	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
637905002010	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
637905002011	dimerization domain [polypeptide binding]; other site
637905002012	dimer interface [polypeptide binding]; other site
637905002013	catalytic residues [active]
637905002014	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
637905002015	DHH family; Region: DHH; pfam01368
637905002016	DHHA1 domain; Region: DHHA1; pfam02272
637905002017	AhpC/TSA family; Region: AhpC-TSA; pfam00578
637905002018	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
637905002019	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
637905002020	catalytic residues [active]
637905002021	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
637905002022	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
637905002023	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637905002024	DNA binding site [nucleotide binding]
637905002025	Predicted integral membrane protein [Function unknown]; Region: COG5616
637905002026	SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102
637905002027	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
637905002028	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
637905002029	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
637905002030	tetramer (dimer of dimers) interface [polypeptide binding]; other site
637905002031	active site
637905002032	dimer interface [polypeptide binding]; other site
637905002033	Protein of unknown function (DUF808); Region: DUF808; pfam05661
637905002034	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
637905002035	active site
637905002036	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905002037	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905002038	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
637905002039	dimerization interface [polypeptide binding]; other site
637905002040	LrgA family; Region: LrgA; cl00608
637905002041	LrgB-like family; Region: LrgB; pfam04172
637905002042	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
637905002043	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
637905002044	active site
637905002045	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
637905002046	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
637905002047	uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722
637905002048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
637905002049	SlyX; Region: SlyX; pfam04102
637905002050	FOG: WD40 repeat [General function prediction only]; Region: COG2319
637905002051	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
637905002052	structural tetrad; other site
637905002053	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
637905002054	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
637905002055	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
637905002056	Uncharacterized protein family (UPF0231); Region: UPF0231; pfam06062
637905002057	transcriptional regulator NarL; Provisional; Region: PRK10651
637905002058	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905002059	active site
637905002060	phosphorylation site [posttranslational modification]
637905002061	intermolecular recognition site; other site
637905002062	dimerization interface [polypeptide binding]; other site
637905002063	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
637905002064	DNA binding residues [nucleotide binding]
637905002065	dimerization interface [polypeptide binding]; other site
637905002066	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
637905002067	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
637905002068	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905002069	dimerization interface [polypeptide binding]; other site
637905002070	Histidine kinase; Region: HisKA_3; pfam07730
637905002071	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905002072	ATP binding site [chemical binding]; other site
637905002073	Mg2+ binding site [ion binding]; other site
637905002074	G-X-G motif; other site
637905002075	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
637905002076	Nitrogen regulatory protein P-II; Region: P-II; smart00938
637905002077	probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644
637905002078	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
637905002079	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
637905002080	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
637905002081	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
637905002082	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
637905002083	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637905002084	Walker A/P-loop; other site
637905002085	ATP binding site [chemical binding]; other site
637905002086	Q-loop/lid; other site
637905002087	ABC transporter signature motif; other site
637905002088	Walker B; other site
637905002089	D-loop; other site
637905002090	H-loop/switch region; other site
637905002091	ferredoxin-NADP reductase; Provisional; Region: PRK10926
637905002092	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
637905002093	FAD binding pocket [chemical binding]; other site
637905002094	FAD binding motif [chemical binding]; other site
637905002095	phosphate binding motif [ion binding]; other site
637905002096	beta-alpha-beta structure motif; other site
637905002097	NAD binding pocket [chemical binding]; other site
637905002098	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
637905002099	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
637905002100	putative C-terminal domain interface [polypeptide binding]; other site
637905002101	putative GSH binding site (G-site) [chemical binding]; other site
637905002102	putative dimer interface [polypeptide binding]; other site
637905002103	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
637905002104	dimer interface [polypeptide binding]; other site
637905002105	N-terminal domain interface [polypeptide binding]; other site
637905002106	substrate binding pocket (H-site) [chemical binding]; other site
637905002107	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
637905002108	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
637905002109	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
637905002110	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
637905002111	dimer interface [polypeptide binding]; other site
637905002112	conserved gate region; other site
637905002113	putative PBP binding loops; other site
637905002114	ABC-ATPase subunit interface; other site
637905002115	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
637905002116	dimer interface [polypeptide binding]; other site
637905002117	conserved gate region; other site
637905002118	putative PBP binding loops; other site
637905002119	ABC-ATPase subunit interface; other site
637905002120	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
637905002121	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
637905002122	Walker A/P-loop; other site
637905002123	ATP binding site [chemical binding]; other site
637905002124	Q-loop/lid; other site
637905002125	ABC transporter signature motif; other site
637905002126	Walker B; other site
637905002127	D-loop; other site
637905002128	H-loop/switch region; other site
637905002129	TOBE domain; Region: TOBE_2; pfam08402
637905002130	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
637905002131	Cupin domain; Region: Cupin_2; cl17218
637905002132	arginine repressor; Provisional; Region: PRK05066
637905002133	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
637905002134	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
637905002135	malate dehydrogenase; Provisional; Region: PRK05086
637905002136	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
637905002137	NAD binding site [chemical binding]; other site
637905002138	dimerization interface [polypeptide binding]; other site
637905002139	Substrate binding site [chemical binding]; other site
637905002140	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
637905002141	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
637905002142	substrate binding pocket [chemical binding]; other site
637905002143	chain length determination region; other site
637905002144	substrate-Mg2+ binding site; other site
637905002145	catalytic residues [active]
637905002146	aspartate-rich region 1; other site
637905002147	active site lid residues [active]
637905002148	aspartate-rich region 2; other site
637905002149	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
637905002150	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
637905002151	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
637905002152	GTPase CgtA; Reviewed; Region: obgE; PRK12298
637905002153	GTP1/OBG; Region: GTP1_OBG; pfam01018
637905002154	Obg GTPase; Region: Obg; cd01898
637905002155	G1 box; other site
637905002156	GTP/Mg2+ binding site [chemical binding]; other site
637905002157	Switch I region; other site
637905002158	G2 box; other site
637905002159	G3 box; other site
637905002160	Switch II region; other site
637905002161	G4 box; other site
637905002162	G5 box; other site
637905002163	Uncharacterized conserved protein [Function unknown]; Region: COG2966
637905002164	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
637905002165	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
637905002166	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
637905002167	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
637905002168	NADP+ binding site [chemical binding]; other site
637905002169	folate binding site [chemical binding]; other site
637905002170	Protein of unknown function (DUF3718); Region: DUF3718; pfam12514
637905002171	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905002172	dimerization interface [polypeptide binding]; other site
637905002173	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
637905002174	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905002175	dimer interface [polypeptide binding]; other site
637905002176	putative CheW interface [polypeptide binding]; other site
637905002177	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
637905002178	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
637905002179	active site
637905002180	metal binding site [ion binding]; metal-binding site
637905002181	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
637905002182	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
637905002183	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
637905002184	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
637905002185	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
637905002186	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
637905002187	SurA N-terminal domain; Region: SurA_N; pfam09312
637905002188	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
637905002189	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
637905002190	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
637905002191	OstA-like protein; Region: OstA; cl00844
637905002192	Organic solvent tolerance protein; Region: OstA_C; pfam04453
637905002193	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
637905002194	Phosphotransferase enzyme family; Region: APH; pfam01636
637905002195	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
637905002196	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
637905002197	Substrate binding site; other site
637905002198	metal-binding site
637905002199	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
637905002200	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
637905002201	putative metal binding site [ion binding]; other site
637905002202	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
637905002203	HSP70 interaction site [polypeptide binding]; other site
637905002204	glycerate dehydrogenase; Provisional; Region: PRK06487
637905002205	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
637905002206	putative ligand binding site [chemical binding]; other site
637905002207	putative NAD binding site [chemical binding]; other site
637905002208	catalytic site [active]
637905002209	Protein of unknown function (DUF1289); Region: DUF1289; cl01304
637905002210	sensor protein RstB; Provisional; Region: PRK10604
637905002211	HAMP domain; Region: HAMP; pfam00672
637905002212	dimerization interface [polypeptide binding]; other site
637905002213	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
637905002214	dimer interface [polypeptide binding]; other site
637905002215	phosphorylation site [posttranslational modification]
637905002216	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905002217	ATP binding site [chemical binding]; other site
637905002218	Mg2+ binding site [ion binding]; other site
637905002219	G-X-G motif; other site
637905002220	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
637905002221	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905002222	active site
637905002223	phosphorylation site [posttranslational modification]
637905002224	intermolecular recognition site; other site
637905002225	dimerization interface [polypeptide binding]; other site
637905002226	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637905002227	DNA binding site [nucleotide binding]
637905002228	Protein of unknown function (DUF3019); Region: DUF3019; pfam11456
637905002229	MltA-interacting protein MipA; Region: MipA; cl01504
637905002230	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905002231	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905002232	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
637905002233	dimerization interface [polypeptide binding]; other site
637905002234	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
637905002235	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
637905002236	FAD binding site [chemical binding]; other site
637905002237	substrate binding pocket [chemical binding]; other site
637905002238	catalytic base [active]
637905002239	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
637905002240	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
637905002241	tetramer interface [polypeptide binding]; other site
637905002242	TPP-binding site [chemical binding]; other site
637905002243	heterodimer interface [polypeptide binding]; other site
637905002244	phosphorylation loop region [posttranslational modification]
637905002245	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
637905002246	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
637905002247	alpha subunit interface [polypeptide binding]; other site
637905002248	TPP binding site [chemical binding]; other site
637905002249	heterodimer interface [polypeptide binding]; other site
637905002250	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
637905002251	Acyl transferase domain; Region: Acyl_transf_1; cl08282
637905002252	putative acetyltransferase YhhY; Provisional; Region: PRK10140
637905002253	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637905002254	Coenzyme A binding pocket [chemical binding]; other site
637905002255	Domain of unknown function (DUF1971); Region: DUF1971; pfam09313
637905002256	Domain of unknown function (DUF1971); Region: DUF1971; pfam09313
637905002257	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
637905002258	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
637905002259	Predicted transcriptional regulator [Transcription]; Region: COG2345
637905002260	HTH domain; Region: HTH_11; pfam08279
637905002261	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
637905002262	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
637905002263	RNA binding surface [nucleotide binding]; other site
637905002264	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
637905002265	active site
637905002266	uracil binding [chemical binding]; other site
637905002267	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
637905002268	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905002269	Major Facilitator Superfamily; Region: MFS_1; pfam07690
637905002270	putative substrate translocation pore; other site
637905002271	AMMECR1; Region: AMMECR1; pfam01871
637905002272	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
637905002273	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
637905002274	putative ligand binding pocket/active site [active]
637905002275	putative metal binding site [ion binding]; other site
637905002276	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
637905002277	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637905002278	FeS/SAM binding site; other site
637905002279	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
637905002280	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
637905002281	HIGH motif; other site
637905002282	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
637905002283	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
637905002284	active site
637905002285	KMSKS motif; other site
637905002286	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
637905002287	tRNA binding surface [nucleotide binding]; other site
637905002288	anticodon binding site; other site
637905002289	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
637905002290	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
637905002291	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
637905002292	FG-GAP repeat; Region: FG-GAP_2; pfam14312
637905002293	FG-GAP repeat; Region: FG-GAP_2; pfam14312
637905002294	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
637905002295	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
637905002296	active site
637905002297	metal binding site [ion binding]; metal-binding site
637905002298	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
637905002299	multifunctional aminopeptidase A; Provisional; Region: PRK00913
637905002300	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
637905002301	interface (dimer of trimers) [polypeptide binding]; other site
637905002302	Substrate-binding/catalytic site; other site
637905002303	Zn-binding sites [ion binding]; other site
637905002304	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
637905002305	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
637905002306	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
637905002307	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
637905002308	RDD family; Region: RDD; pfam06271
637905002309	Protein of unknown function (DUF2960); Region: DUF2960; pfam11173
637905002310	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
637905002311	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637905002312	Coenzyme A binding pocket [chemical binding]; other site
637905002313	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
637905002314	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
637905002315	active site
637905002316	Zn binding site [ion binding]; other site
637905002317	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
637905002318	Protein of unknown function (DUF2913); Region: DUF2913; pfam11140
637905002319	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
637905002320	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
637905002321	ATP binding site [chemical binding]; other site
637905002322	Mg++ binding site [ion binding]; other site
637905002323	motif III; other site
637905002324	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905002325	nucleotide binding region [chemical binding]; other site
637905002326	ATP-binding site [chemical binding]; other site
637905002327	Response regulator receiver domain; Region: Response_reg; pfam00072
637905002328	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905002329	active site
637905002330	phosphorylation site [posttranslational modification]
637905002331	intermolecular recognition site; other site
637905002332	dimerization interface [polypeptide binding]; other site
637905002333	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
637905002334	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
637905002335	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
637905002336	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
637905002337	active site
637905002338	Major Facilitator Superfamily; Region: MFS_1; pfam07690
637905002339	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905002340	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
637905002341	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
637905002342	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
637905002343	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
637905002344	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
637905002345	active site
637905002346	N-terminal Early set domain associated with the catalytic domain of chitinase; Region: E_set_Chitinase_N; cd02848
637905002347	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
637905002348	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
637905002349	active site
637905002350	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
637905002351	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
637905002352	aromatic chitin/cellulose binding site residues [chemical binding]; other site
637905002353	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
637905002354	aromatic chitin/cellulose binding site residues [chemical binding]; other site
637905002355	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
637905002356	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
637905002357	putative sugar binding site [chemical binding]; other site
637905002358	catalytic residues [active]
637905002359	Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046
637905002360	aromatic chitin/cellulose binding site residues [chemical binding]; other site
637905002361	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
637905002362	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
637905002363	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
637905002364	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
637905002365	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
637905002366	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
637905002367	active site
637905002368	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
637905002369	Predicted integral membrane protein [Function unknown]; Region: COG5615
637905002370	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
637905002371	CoenzymeA binding site [chemical binding]; other site
637905002372	subunit interaction site [polypeptide binding]; other site
637905002373	PHB binding site; other site
637905002374	Domain of unknown function (DUF368); Region: DUF368; pfam04018
637905002375	Protein of unknown function (DUF3634); Region: DUF3634; pfam12321
637905002376	Cellulose binding domain; Region: CBM_2; pfam00553
637905002377	FOG: PKD repeat [General function prediction only]; Region: COG3291
637905002378	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
637905002379	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
637905002380	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
637905002381	Helix-turn-helix domain; Region: HTH_18; pfam12833
637905002382	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
637905002383	Bacterial Ig-like domain; Region: Big_5; pfam13205
637905002384	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
637905002385	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
637905002386	Cellulose binding domain; Region: CBM_2; pfam00553
637905002387	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
637905002388	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
637905002389	Cellulose binding domain; Region: CBM_2; cl17741
637905002390	Cellulose binding domain; Region: CBM_2; pfam00553
637905002391	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
637905002392	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
637905002393	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
637905002394	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
637905002395	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
637905002396	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
637905002397	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
637905002398	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
637905002399	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
637905002400	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
637905002401	DNA binding residues [nucleotide binding]
637905002402	DNA primase; Validated; Region: dnaG; PRK05667
637905002403	CHC2 zinc finger; Region: zf-CHC2; pfam01807
637905002404	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
637905002405	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
637905002406	active site
637905002407	metal binding site [ion binding]; metal-binding site
637905002408	interdomain interaction site; other site
637905002409	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
637905002410	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
637905002411	Yqey-like protein; Region: YqeY; pfam09424
637905002412	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
637905002413	UGMP family protein; Validated; Region: PRK09604
637905002414	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
637905002415	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
637905002416	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
637905002417	homooctamer interface [polypeptide binding]; other site
637905002418	active site
637905002419	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
637905002420	catalytic center binding site [active]
637905002421	ATP binding site [chemical binding]; other site
637905002422	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
637905002423	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
637905002424	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
637905002425	L,D-transpeptidase; Provisional; Region: PRK10190
637905002426	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
637905002427	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
637905002428	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
637905002429	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
637905002430	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
637905002431	active site
637905002432	NTP binding site [chemical binding]; other site
637905002433	metal binding triad [ion binding]; metal-binding site
637905002434	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
637905002435	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
637905002436	Zn2+ binding site [ion binding]; other site
637905002437	Mg2+ binding site [ion binding]; other site
637905002438	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
637905002439	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905002440	Walker A motif; other site
637905002441	ATP binding site [chemical binding]; other site
637905002442	Walker B motif; other site
637905002443	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
637905002444	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
637905002445	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
637905002446	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
637905002447	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
637905002448	inhibitor-cofactor binding pocket; inhibition site
637905002449	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905002450	catalytic residue [active]
637905002451	aspartate carbamoyltransferase; Provisional; Region: PRK08192
637905002452	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
637905002453	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
637905002454	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
637905002455	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
637905002456	Cl- selectivity filter; other site
637905002457	Cl- binding residues [ion binding]; other site
637905002458	pore gating glutamate residue; other site
637905002459	dimer interface [polypeptide binding]; other site
637905002460	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
637905002461	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
637905002462	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
637905002463	amphipathic channel; other site
637905002464	Asn-Pro-Ala signature motifs; other site
637905002465	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
637905002466	putative peptidase; Provisional; Region: PRK11649
637905002467	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
637905002468	Peptidase family M23; Region: Peptidase_M23; pfam01551
637905002469	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
637905002470	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
637905002471	active site
637905002472	HIGH motif; other site
637905002473	dimer interface [polypeptide binding]; other site
637905002474	KMSKS motif; other site
637905002475	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
637905002476	RNA binding surface [nucleotide binding]; other site
637905002477	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
637905002478	POT family; Region: PTR2; cl17359
637905002479	SnoaL-like domain; Region: SnoaL_2; pfam12680
637905002480	hypothetical protein; Provisional; Region: PRK10578
637905002481	UPF0126 domain; Region: UPF0126; pfam03458
637905002482	UPF0126 domain; Region: UPF0126; pfam03458
637905002483	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
637905002484	Cobalamin biosynthesis protein CobD/CbiB [Coenzyme metabolism]; Region: CbiB; COG1270
637905002485	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
637905002486	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
637905002487	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
637905002488	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
637905002489	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
637905002490	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
637905002491	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
637905002492	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
637905002493	active site
637905002494	dimer interface [polypeptide binding]; other site
637905002495	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
637905002496	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
637905002497	active site
637905002498	FMN binding site [chemical binding]; other site
637905002499	substrate binding site [chemical binding]; other site
637905002500	3Fe-4S cluster binding site [ion binding]; other site
637905002501	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
637905002502	domain interface; other site
637905002503	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
637905002504	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
637905002505	putative binding surface; other site
637905002506	active site
637905002507	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
637905002508	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905002509	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
637905002510	dimerization interface [polypeptide binding]; other site
637905002511	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
637905002512	cyclase homology domain; Region: CHD; cd07302
637905002513	nucleotidyl binding site; other site
637905002514	metal binding site [ion binding]; metal-binding site
637905002515	dimer interface [polypeptide binding]; other site
637905002516	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
637905002517	putative DNA-binding cleft [nucleotide binding]; other site
637905002518	putative DNA clevage site; other site
637905002519	molecular lever; other site
637905002520	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
637905002521	putative active site [active]
637905002522	Ap4A binding site [chemical binding]; other site
637905002523	nudix motif; other site
637905002524	putative metal binding site [ion binding]; other site
637905002525	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
637905002526	GAF domain; Region: GAF; pfam01590
637905002527	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
637905002528	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
637905002529	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
637905002530	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
637905002531	thymidylate synthase; Reviewed; Region: thyA; PRK01827
637905002532	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
637905002533	dimerization interface [polypeptide binding]; other site
637905002534	active site
637905002535	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
637905002536	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
637905002537	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905002538	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
637905002539	dimerization interface [polypeptide binding]; other site
637905002540	Uncharacterized conserved protein [Function unknown]; Region: COG2938
637905002541	L-aspartate oxidase; Provisional; Region: PRK09077
637905002542	L-aspartate oxidase; Provisional; Region: PRK06175
637905002543	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
637905002544	RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923
637905002545	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
637905002546	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
637905002547	DNA binding residues [nucleotide binding]
637905002548	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
637905002549	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
637905002550	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
637905002551	anti-sigma E factor; Provisional; Region: rseB; PRK09455
637905002552	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
637905002553	GTP-binding protein LepA; Provisional; Region: PRK05433
637905002554	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
637905002555	G1 box; other site
637905002556	putative GEF interaction site [polypeptide binding]; other site
637905002557	GTP/Mg2+ binding site [chemical binding]; other site
637905002558	Switch I region; other site
637905002559	G2 box; other site
637905002560	G3 box; other site
637905002561	Switch II region; other site
637905002562	G4 box; other site
637905002563	G5 box; other site
637905002564	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
637905002565	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
637905002566	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
637905002567	signal peptidase I; Provisional; Region: PRK10861
637905002568	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
637905002569	Catalytic site [active]
637905002570	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
637905002571	ribonuclease III; Reviewed; Region: rnc; PRK00102
637905002572	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
637905002573	dimerization interface [polypeptide binding]; other site
637905002574	active site
637905002575	metal binding site [ion binding]; metal-binding site
637905002576	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
637905002577	dsRNA binding site [nucleotide binding]; other site
637905002578	GTPase Era; Reviewed; Region: era; PRK00089
637905002579	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
637905002580	G1 box; other site
637905002581	GTP/Mg2+ binding site [chemical binding]; other site
637905002582	Switch I region; other site
637905002583	G2 box; other site
637905002584	Switch II region; other site
637905002585	G3 box; other site
637905002586	G4 box; other site
637905002587	G5 box; other site
637905002588	KH domain; Region: KH_2; pfam07650
637905002589	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
637905002590	Recombination protein O N terminal; Region: RecO_N; pfam11967
637905002591	Recombination protein O C terminal; Region: RecO_C; pfam02565
637905002592	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
637905002593	active site
637905002594	hydrophilic channel; other site
637905002595	dimerization interface [polypeptide binding]; other site
637905002596	catalytic residues [active]
637905002597	active site lid [active]
637905002598	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
637905002599	B12 binding domain; Region: B12-binding; pfam02310
637905002600	B12 binding site [chemical binding]; other site
637905002601	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
637905002602	A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases.  Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417
637905002603	type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846
637905002604	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
637905002605	ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252
637905002606	Walker A/P-loop; other site
637905002607	ATP binding site [chemical binding]; other site
637905002608	Q-loop/lid; other site
637905002609	ABC transporter signature motif; other site
637905002610	Walker B; other site
637905002611	D-loop; other site
637905002612	H-loop/switch region; other site
637905002613	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
637905002614	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637905002615	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905002616	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
637905002617	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
637905002618	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
637905002619	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
637905002620	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
637905002621	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
637905002622	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
637905002623	Protein of unknown function (DUF962); Region: DUF962; cl01879
637905002624	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
637905002625	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
637905002626	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
637905002627	active site
637905002628	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905002629	Major Facilitator Superfamily; Region: MFS_1; pfam07690
637905002630	putative substrate translocation pore; other site
637905002631	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905002632	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905002633	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905002634	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
637905002635	dimerization interface [polypeptide binding]; other site
637905002636	hypothetical protein; Provisional; Region: PRK11573
637905002637	Domain of unknown function DUF21; Region: DUF21; pfam01595
637905002638	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
637905002639	Transporter associated domain; Region: CorC_HlyC; smart01091
637905002640	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
637905002641	signal recognition particle protein; Provisional; Region: PRK10867
637905002642	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
637905002643	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
637905002644	P loop; other site
637905002645	GTP binding site [chemical binding]; other site
637905002646	Signal peptide binding domain; Region: SRP_SPB; pfam02978
637905002647	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
637905002648	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
637905002649	RimM N-terminal domain; Region: RimM; pfam01782
637905002650	PRC-barrel domain; Region: PRC; pfam05239
637905002651	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
637905002652	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
637905002653	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
637905002654	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
637905002655	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
637905002656	Chorismate mutase type II; Region: CM_2; cl00693
637905002657	prephenate dehydrogenase; Validated; Region: PRK08507
637905002658	hybrid cluster protein; Provisional; Region: PRK05290
637905002659	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
637905002660	ACS interaction site; other site
637905002661	CODH interaction site; other site
637905002662	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
637905002663	ACS interaction site; other site
637905002664	CODH interaction site; other site
637905002665	metal cluster binding site [ion binding]; other site
637905002666	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
637905002667	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
637905002668	FAD binding pocket [chemical binding]; other site
637905002669	FAD binding motif [chemical binding]; other site
637905002670	phosphate binding motif [ion binding]; other site
637905002671	beta-alpha-beta structure motif; other site
637905002672	NAD binding pocket [chemical binding]; other site
637905002673	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
637905002674	catalytic loop [active]
637905002675	iron binding site [ion binding]; other site
637905002676	Predicted membrane protein [Function unknown]; Region: COG3671
637905002677	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
637905002678	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
637905002679	Prephenate dehydratase; Region: PDT; pfam00800
637905002680	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
637905002681	putative L-Phe binding site [chemical binding]; other site
637905002682	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876
637905002683	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
637905002684	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
637905002685	30S subunit binding site; other site
637905002686	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
637905002687	Cytochrome C' Region: Cytochrom_C_2; pfam01322
637905002688	Trp repressor protein; Region: Trp_repressor; cl17266
637905002689	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
637905002690	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
637905002691	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
637905002692	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
637905002693	putative catalytic residues [active]
637905002694	putative nucleotide binding site [chemical binding]; other site
637905002695	putative aspartate binding site [chemical binding]; other site
637905002696	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
637905002697	dimer interface [polypeptide binding]; other site
637905002698	putative threonine allosteric regulatory site; other site
637905002699	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
637905002700	putative threonine allosteric regulatory site; other site
637905002701	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
637905002702	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
637905002703	homoserine kinase; Provisional; Region: PRK01212
637905002704	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
637905002705	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
637905002706	threonine synthase; Validated; Region: PRK09225
637905002707	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
637905002708	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
637905002709	catalytic residue [active]
637905002710	endonuclease IV; Provisional; Region: PRK01060
637905002711	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
637905002712	AP (apurinic/apyrimidinic) site pocket; other site
637905002713	DNA interaction; other site
637905002714	Metal-binding active site; metal-binding site
637905002715	DOMON domain; Region: DOMON; pfam03351
637905002716	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
637905002717	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
637905002718	putative active site [active]
637905002719	heme pocket [chemical binding]; other site
637905002720	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
637905002721	dimer interface [polypeptide binding]; other site
637905002722	phosphorylation site [posttranslational modification]
637905002723	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905002724	ATP binding site [chemical binding]; other site
637905002725	Mg2+ binding site [ion binding]; other site
637905002726	G-X-G motif; other site
637905002727	Response regulator receiver domain; Region: Response_reg; pfam00072
637905002728	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905002729	active site
637905002730	phosphorylation site [posttranslational modification]
637905002731	intermolecular recognition site; other site
637905002732	dimerization interface [polypeptide binding]; other site
637905002733	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905002734	Response regulator receiver domain; Region: Response_reg; pfam00072
637905002735	active site
637905002736	phosphorylation site [posttranslational modification]
637905002737	intermolecular recognition site; other site
637905002738	dimerization interface [polypeptide binding]; other site
637905002739	Hemerythrin-like domain; Region: Hr-like; cd12108
637905002740	Fe binding site [ion binding]; other site
637905002741	Protein of unknown function (DUF3545); Region: DUF3545; pfam12065
637905002742	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
637905002743	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
637905002744	active site
637905002745	dimer interface [polypeptide binding]; other site
637905002746	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
637905002747	dimer interface [polypeptide binding]; other site
637905002748	active site
637905002749	transaldolase-like protein; Provisional; Region: PTZ00411
637905002750	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
637905002751	active site
637905002752	dimer interface [polypeptide binding]; other site
637905002753	catalytic residue [active]
637905002754	outer membrane protein A; Reviewed; Region: PRK10808
637905002755	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
637905002756	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
637905002757	ligand binding site [chemical binding]; other site
637905002758	putative phosphoketolase; Provisional; Region: PRK05261
637905002759	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
637905002760	TPP-binding site; other site
637905002761	XFP C-terminal domain; Region: XFP_C; pfam09363
637905002762	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
637905002763	amino acid carrier protein; Region: agcS; TIGR00835
637905002764	hypothetical protein; Validated; Region: PRK02101
637905002765	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
637905002766	Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894
637905002767	Integral membrane protein TerC family; Region: TerC; cl10468
637905002768	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
637905002769	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
637905002770	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905002771	binding surface
637905002772	TPR repeat; Region: TPR_11; pfam13414
637905002773	TPR motif; other site
637905002774	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
637905002775	PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815
637905002776	PA/protease or protease-like domain interface [polypeptide binding]; other site
637905002777	M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883
637905002778	Peptidase family M28; Region: Peptidase_M28; pfam04389
637905002779	metal binding site [ion binding]; metal-binding site
637905002780	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
637905002781	dimerization interface [polypeptide binding]; other site
637905002782	putative DNA binding site [nucleotide binding]; other site
637905002783	putative Zn2+ binding site [ion binding]; other site
637905002784	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
637905002785	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
637905002786	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
637905002787	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
637905002788	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
637905002789	active site
637905002790	Riboflavin kinase; Region: Flavokinase; smart00904
637905002791	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
637905002792	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
637905002793	active site
637905002794	HIGH motif; other site
637905002795	nucleotide binding site [chemical binding]; other site
637905002796	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
637905002797	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
637905002798	active site
637905002799	KMSKS motif; other site
637905002800	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
637905002801	tRNA binding surface [nucleotide binding]; other site
637905002802	anticodon binding site; other site
637905002803	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
637905002804	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
637905002805	lipoprotein signal peptidase; Provisional; Region: PRK14787
637905002806	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
637905002807	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
637905002808	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
637905002809	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
637905002810	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
637905002811	PilX N-terminal; Region: PilX_N; pfam14341
637905002812	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
637905002813	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
637905002814	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
637905002815	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
637905002816	Type II transport protein GspH; Region: GspH; pfam12019
637905002817	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
637905002818	Type II transport protein GspH; Region: GspH; pfam12019
637905002819	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
637905002820	Nitrogen regulatory protein P-II; Region: P-II; smart00938
637905002821	Transcriptional regulators [Transcription]; Region: PurR; COG1609
637905002822	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
637905002823	DNA binding site [nucleotide binding]
637905002824	domain linker motif; other site
637905002825	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
637905002826	putative dimerization interface [polypeptide binding]; other site
637905002827	putative ligand binding site [chemical binding]; other site
637905002828	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
637905002829	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905002830	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905002831	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
637905002832	SapC; Region: SapC; pfam07277
637905002833	Putative carbohydrate binding domain; Region: CHB_HEX; smart01081
637905002834	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569
637905002835	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
637905002836	active site
637905002837	C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847
637905002838	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
637905002839	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
637905002840	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
637905002841	active site
637905002842	dimer interface [polypeptide binding]; other site
637905002843	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
637905002844	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
637905002845	hypothetical protein; Provisional; Region: PRK03757
637905002846	oxidative damage protection protein; Provisional; Region: PRK05408
637905002847	adenine DNA glycosylase; Provisional; Region: PRK10880
637905002848	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
637905002849	minor groove reading motif; other site
637905002850	helix-hairpin-helix signature motif; other site
637905002851	substrate binding pocket [chemical binding]; other site
637905002852	active site
637905002853	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
637905002854	DNA binding and oxoG recognition site [nucleotide binding]
637905002855	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905002856	S-adenosylmethionine binding site [chemical binding]; other site
637905002857	hypothetical protein; Provisional; Region: PRK11702
637905002858	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
637905002859	glutaminase; Provisional; Region: PRK00971
637905002860	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
637905002861	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905002862	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905002863	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
637905002864	putative effector binding pocket; other site
637905002865	dimerization interface [polypeptide binding]; other site
637905002866	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
637905002867	HemN family oxidoreductase; Provisional; Region: PRK05660
637905002868	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637905002869	FeS/SAM binding site; other site
637905002870	HemN C-terminal domain; Region: HemN_C; pfam06969
637905002871	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
637905002872	active site
637905002873	dimerization interface [polypeptide binding]; other site
637905002874	Domain of unknown function (DUF4426); Region: DUF4426; pfam14467
637905002875	hypothetical protein; Validated; Region: PRK05090
637905002876	YGGT family; Region: YGGT; pfam02325
637905002877	YGGT family; Region: YGGT; pfam02325
637905002878	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
637905002879	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
637905002880	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
637905002881	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
637905002882	catalytic residue [active]
637905002883	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
637905002884	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
637905002885	Walker A motif; other site
637905002886	ATP binding site [chemical binding]; other site
637905002887	Walker B motif; other site
637905002888	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
637905002889	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
637905002890	Walker A motif; other site
637905002891	ATP binding site [chemical binding]; other site
637905002892	Walker B motif; other site
637905002893	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
637905002894	hypothetical protein; Validated; Region: PRK00228
637905002895	translation initiation factor Sui1; Validated; Region: PRK06824
637905002896	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
637905002897	putative rRNA binding site [nucleotide binding]; other site
637905002898	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
637905002899	Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561
637905002900	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
637905002901	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
637905002902	ligand binding site [chemical binding]; other site
637905002903	mechanosensitive channel MscS; Provisional; Region: PRK10334
637905002904	Conserved TM helix; Region: TM_helix; pfam05552
637905002905	Mechanosensitive ion channel; Region: MS_channel; pfam00924
637905002906	Predicted membrane protein [Function unknown]; Region: COG2860
637905002907	UPF0126 domain; Region: UPF0126; pfam03458
637905002908	UPF0126 domain; Region: UPF0126; pfam03458
637905002909	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
637905002910	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
637905002911	tetramer interface [polypeptide binding]; other site
637905002912	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905002913	catalytic residue [active]
637905002914	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
637905002915	Alkaline phosphatase homologues; Region: alkPPc; smart00098
637905002916	active site
637905002917	dimer interface [polypeptide binding]; other site
637905002918	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
637905002919	dimer interface [polypeptide binding]; other site
637905002920	Alkaline phosphatase homologues; Region: alkPPc; smart00098
637905002921	active site
637905002922	BCCT family transporter; Region: BCCT; pfam02028
637905002923	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
637905002924	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
637905002925	substrate binding pocket [chemical binding]; other site
637905002926	membrane-bound complex binding site; other site
637905002927	hinge residues; other site
637905002928	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
637905002929	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637905002930	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905002931	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
637905002932	Protein export membrane protein; Region: SecD_SecF; cl14618
637905002933	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
637905002934	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
637905002935	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
637905002936	putative alcohol dehydrogenase; Provisional; Region: PRK09860
637905002937	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
637905002938	dimer interface [polypeptide binding]; other site
637905002939	active site
637905002940	metal binding site [ion binding]; metal-binding site
637905002941	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
637905002942	glycogen branching enzyme; Provisional; Region: PRK05402
637905002943	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
637905002944	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
637905002945	active site
637905002946	catalytic site [active]
637905002947	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
637905002948	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
637905002949	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
637905002950	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
637905002951	active site
637905002952	catalytic site [active]
637905002953	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
637905002954	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
637905002955	active site pocket [active]
637905002956	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
637905002957	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
637905002958	ligand binding site; other site
637905002959	oligomer interface; other site
637905002960	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
637905002961	dimer interface [polypeptide binding]; other site
637905002962	N-terminal domain interface [polypeptide binding]; other site
637905002963	sulfate 1 binding site; other site
637905002964	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
637905002965	glycogen/starch synthase, ADP-glucose type; Region: glgA; TIGR02095
637905002966	ADP-binding pocket [chemical binding]; other site
637905002967	homodimer interface [polypeptide binding]; other site
637905002968	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
637905002969	putative deacylase active site [active]
637905002970	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
637905002971	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
637905002972	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
637905002973	catalytic residues [active]
637905002974	dimer interface [polypeptide binding]; other site
637905002975	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
637905002976	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
637905002977	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905002978	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905002979	metal binding site [ion binding]; metal-binding site
637905002980	active site
637905002981	I-site; other site
637905002982	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
637905002983	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
637905002984	16S rRNA methyltransferase B; Provisional; Region: PRK14902
637905002985	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905002986	S-adenosylmethionine binding site [chemical binding]; other site
637905002987	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
637905002988	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
637905002989	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905002990	putative substrate translocation pore; other site
637905002991	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
637905002992	active site
637905002993	active site
637905002994	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
637905002995	FOG: PKD repeat [General function prediction only]; Region: COG3291
637905002996	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
637905002997	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
637905002998	Interdomain contacts; other site
637905002999	Cytokine receptor motif; other site
637905003000	Pregnancy-associated plasma protein-A; Region: Peptidase_M43; cl17409
637905003001	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
637905003002	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
637905003003	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
637905003004	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
637905003005	Flp pilus assembly protein CpaB; Region: pilus_cpaB; TIGR03177
637905003006	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
637905003007	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
637905003008	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
637905003009	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
637905003010	Type IV pili component [Cell motility and secretion]; Region: COG5461
637905003011	septum site-determining protein MinD; Region: minD_bact; TIGR01968
637905003012	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
637905003013	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
637905003014	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
637905003015	ATP binding site [chemical binding]; other site
637905003016	Walker A motif; other site
637905003017	hexamer interface [polypeptide binding]; other site
637905003018	Walker B motif; other site
637905003019	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
637905003020	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
637905003021	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
637905003022	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
637905003023	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
637905003024	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905003025	TPR motif; other site
637905003026	binding surface
637905003027	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905003028	TPR motif; other site
637905003029	binding surface
637905003030	von Willebrand factor type A domain; Region: VWA_2; pfam13519
637905003031	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
637905003032	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
637905003033	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
637905003034	catalytic residues [active]
637905003035	Domain of unknown function (DUF4266); Region: DUF4266; pfam14086
637905003036	Protein of unknown function (DUF3570); Region: DUF3570; pfam12094
637905003037	ApbE family; Region: ApbE; pfam02424
637905003038	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
637905003039	Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755
637905003040	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
637905003041	C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561
637905003042	Catalytic dyad [active]
637905003043	Protein of unknown function, DUF599; Region: DUF599; pfam04654
637905003044	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
637905003045	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
637905003046	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
637905003047	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
637905003048	dimer interface [polypeptide binding]; other site
637905003049	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
637905003050	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
637905003051	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
637905003052	TPP-binding site; other site
637905003053	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
637905003054	PYR/PP interface [polypeptide binding]; other site
637905003055	dimer interface [polypeptide binding]; other site
637905003056	TPP binding site [chemical binding]; other site
637905003057	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
637905003058	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
637905003059	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
637905003060	substrate binding pocket [chemical binding]; other site
637905003061	chain length determination region; other site
637905003062	substrate-Mg2+ binding site; other site
637905003063	catalytic residues [active]
637905003064	aspartate-rich region 1; other site
637905003065	active site lid residues [active]
637905003066	aspartate-rich region 2; other site
637905003067	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
637905003068	flagellar motor protein PomA; Reviewed; Region: PRK08990
637905003069	flagellar motor protein MotA; Validated; Region: PRK08124
637905003070	flagellar motor protein MotB; Reviewed; Region: motB; PRK08944
637905003071	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
637905003072	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
637905003073	ligand binding site [chemical binding]; other site
637905003074	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
637905003075	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
637905003076	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
637905003077	Ligand Binding Site [chemical binding]; other site
637905003078	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
637905003079	active site residue [active]
637905003080	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905003081	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905003082	metal binding site [ion binding]; metal-binding site
637905003083	active site
637905003084	I-site; other site
637905003085	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
637905003086	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905003087	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
637905003088	dimerization interface [polypeptide binding]; other site
637905003089	substrate binding pocket [chemical binding]; other site
637905003090	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
637905003091	PGAP1-like protein; Region: PGAP1; pfam07819
637905003092	Protein of unknown function (DUF423); Region: DUF423; pfam04241
637905003093	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
637905003094	FtsJ-like methyltransferase; Region: FtsJ; cl17430
637905003095	isocitrate dehydrogenase; Provisional; Region: PRK08997
637905003096	tartrate dehydrogenase; Region: TTC; TIGR02089
637905003097	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
637905003098	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
637905003099	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
637905003100	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
637905003101	C-terminal domain interface [polypeptide binding]; other site
637905003102	GSH binding site (G-site) [chemical binding]; other site
637905003103	dimer interface [polypeptide binding]; other site
637905003104	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
637905003105	N-terminal domain interface [polypeptide binding]; other site
637905003106	dimer interface [polypeptide binding]; other site
637905003107	substrate binding pocket (H-site) [chemical binding]; other site
637905003108	MarC family integral membrane protein; Region: MarC; pfam01914
637905003109	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
637905003110	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
637905003111	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
637905003112	NAD(P) binding site [chemical binding]; other site
637905003113	putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730
637905003114	active site
637905003115	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
637905003116	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
637905003117	Protein of unknown function (DUF3192); Region: DUF3192; pfam11399
637905003118	flap endonuclease-like protein; Provisional; Region: PRK09482
637905003119	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
637905003120	active site
637905003121	metal binding site 1 [ion binding]; metal-binding site
637905003122	putative 5' ssDNA interaction site; other site
637905003123	metal binding site 3; metal-binding site
637905003124	metal binding site 2 [ion binding]; metal-binding site
637905003125	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
637905003126	putative DNA binding site [nucleotide binding]; other site
637905003127	putative metal binding site [ion binding]; other site
637905003128	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
637905003129	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
637905003130	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905003131	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905003132	metal binding site [ion binding]; metal-binding site
637905003133	active site
637905003134	I-site; other site
637905003135	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
637905003136	binding surface
637905003137	TPR motif; other site
637905003138	Tetratricopeptide repeat; Region: TPR_12; pfam13424
637905003139	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905003140	TPR motif; other site
637905003141	binding surface
637905003142	Tetratricopeptide repeat; Region: TPR_12; pfam13424
637905003143	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
637905003144	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
637905003145	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
637905003146	protein binding site [polypeptide binding]; other site
637905003147	recombination associated protein; Reviewed; Region: rdgC; PRK00321
637905003148	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
637905003149	trimer interface [polypeptide binding]; other site
637905003150	eyelet of channel; other site
637905003151	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
637905003152	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
637905003153	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905003154	active site
637905003155	phosphorylation site [posttranslational modification]
637905003156	intermolecular recognition site; other site
637905003157	dimerization interface [polypeptide binding]; other site
637905003158	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637905003159	DNA binding site [nucleotide binding]
637905003160	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
637905003161	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
637905003162	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
637905003163	putative active site [active]
637905003164	heme pocket [chemical binding]; other site
637905003165	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
637905003166	dimer interface [polypeptide binding]; other site
637905003167	phosphorylation site [posttranslational modification]
637905003168	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905003169	ATP binding site [chemical binding]; other site
637905003170	Mg2+ binding site [ion binding]; other site
637905003171	G-X-G motif; other site
637905003172	PBP superfamily domain; Region: PBP_like_2; cl17296
637905003173	MULE transposase domain; Region: MULE; pfam10551
637905003174	delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945
637905003175	Jacalin-like lectin domain; Region: Jacalin_like; cl03205
637905003176	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
637905003177	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
637905003178	leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411
637905003179	Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599
637905003180	active site
637905003181	Zn binding site [ion binding]; other site
637905003182	Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127
637905003183	Uncharacterized conserved protein [Function unknown]; Region: COG1432
637905003184	LabA_like proteins; Region: LabA; cd10911
637905003185	putative metal binding site [ion binding]; other site
637905003186	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905003187	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905003188	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
637905003189	dimerization interface [polypeptide binding]; other site
637905003190	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
637905003191	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637905003192	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905003193	Protein of unknown function (DUF2955); Region: DUF2955; pfam11168
637905003194	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637905003195	Coenzyme A binding pocket [chemical binding]; other site
637905003196	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
637905003197	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
637905003198	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637905003199	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905003200	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
637905003201	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
637905003202	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
637905003203	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
637905003204	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905003205	ATP binding site [chemical binding]; other site
637905003206	Mg2+ binding site [ion binding]; other site
637905003207	G-X-G motif; other site
637905003208	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
637905003209	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905003210	active site
637905003211	phosphorylation site [posttranslational modification]
637905003212	intermolecular recognition site; other site
637905003213	dimerization interface [polypeptide binding]; other site
637905003214	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637905003215	DNA binding site [nucleotide binding]
637905003216	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
637905003217	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
637905003218	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
637905003219	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905003220	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
637905003221	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
637905003222	metal binding site [ion binding]; metal-binding site
637905003223	putative dimer interface [polypeptide binding]; other site
637905003224	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
637905003225	Uncharacterized conserved protein [Function unknown]; Region: COG2128
637905003226	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905003227	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905003228	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
637905003229	putative effector binding pocket; other site
637905003230	dimerization interface [polypeptide binding]; other site
637905003231	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
637905003232	TPR motif; other site
637905003233	binding surface
637905003234	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
637905003235	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
637905003236	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
637905003237	active site
637905003238	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637905003239	Coenzyme A binding pocket [chemical binding]; other site
637905003240	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
637905003241	DNA-binding site [nucleotide binding]; DNA binding site
637905003242	RNA-binding motif; other site
637905003243	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
637905003244	DNA-binding site [nucleotide binding]; DNA binding site
637905003245	RNA-binding motif; other site
637905003246	potential frameshift: common BLAST hit: gi|153000221|ref|YP_001365902.1| phage integrase family protein
637905003247	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
637905003248	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
637905003249	DNA binding site [nucleotide binding]
637905003250	active site
637905003251	Int/Topo IB signature motif; other site
637905003252	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
637905003253	Putative transposase; Region: Y2_Tnp; pfam04986
637905003254	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
637905003255	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
637905003256	FMN binding site [chemical binding]; other site
637905003257	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
637905003258	substrate binding site [chemical binding]; other site
637905003259	putative catalytic residue [active]
637905003260	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
637905003261	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
637905003262	active site
637905003263	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
637905003264	active site
637905003265	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
637905003266	active site 2 [active]
637905003267	dimer interface [polypeptide binding]; other site
637905003268	active site 1 [active]
637905003269	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
637905003270	active site 1 [active]
637905003271	dimer interface [polypeptide binding]; other site
637905003272	active site 2 [active]
637905003273	Acyl transferase domain; Region: Acyl_transf_1; cl08282
637905003274	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
637905003275	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
637905003276	active site
637905003277	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
637905003278	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
637905003279	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
637905003280	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
637905003281	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
637905003282	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
637905003283	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
637905003284	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
637905003285	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
637905003286	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
637905003287	putative NADP binding site [chemical binding]; other site
637905003288	active site
637905003289	Homeodomain-like domain; Region: HTH_23; cl17451
637905003290	elongation factor G; Reviewed; Region: PRK13351
637905003291	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
637905003292	G1 box; other site
637905003293	putative GEF interaction site [polypeptide binding]; other site
637905003294	GTP/Mg2+ binding site [chemical binding]; other site
637905003295	Switch I region; other site
637905003296	G2 box; other site
637905003297	G3 box; other site
637905003298	Switch II region; other site
637905003299	G4 box; other site
637905003300	G5 box; other site
637905003301	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
637905003302	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
637905003303	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
637905003304	CCGSCS motif protein; Region: CCGSCS; TIGR04101
637905003305	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
637905003306	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
637905003307	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
637905003308	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
637905003309	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
637905003310	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905003311	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
637905003312	putative substrate binding pocket [chemical binding]; other site
637905003313	putative dimerization interface [polypeptide binding]; other site
637905003314	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
637905003315	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
637905003316	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
637905003317	SecY interacting protein Syd; Provisional; Region: PRK04968
637905003318	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; pfam10071
637905003319	Protein of unknown function (DUF3192); Region: DUF3192; pfam11399
637905003320	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
637905003321	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
637905003322	Coenzyme A binding pocket [chemical binding]; other site
637905003323	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
637905003324	Protein of unknown function (DUF3549); Region: DUF3549; pfam12069
637905003325	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
637905003326	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
637905003327	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
637905003328	probable active site [active]
637905003329	flavodoxin; Provisional; Region: PRK08105
637905003330	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
637905003331	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
637905003332	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
637905003333	putative active site [active]
637905003334	putative substrate binding site [chemical binding]; other site
637905003335	putative cosubstrate binding site; other site
637905003336	catalytic site [active]
637905003337	Protein of unknown function (DUF3718); Region: DUF3718; pfam12514
637905003338	Protein of unknown function (DUF3718); Region: DUF3718; pfam12514
637905003339	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
637905003340	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
637905003341	trimer interface [polypeptide binding]; other site
637905003342	active site
637905003343	substrate binding site [chemical binding]; other site
637905003344	CoA binding site [chemical binding]; other site
637905003345	PII uridylyl-transferase; Provisional; Region: PRK05007
637905003346	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
637905003347	metal binding triad; other site
637905003348	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
637905003349	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
637905003350	Zn2+ binding site [ion binding]; other site
637905003351	Mg2+ binding site [ion binding]; other site
637905003352	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
637905003353	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
637905003354	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
637905003355	active site
637905003356	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
637905003357	rRNA interaction site [nucleotide binding]; other site
637905003358	S8 interaction site; other site
637905003359	putative laminin-1 binding site; other site
637905003360	elongation factor Ts; Provisional; Region: tsf; PRK09377
637905003361	UBA/TS-N domain; Region: UBA; pfam00627
637905003362	Elongation factor TS; Region: EF_TS; pfam00889
637905003363	Elongation factor TS; Region: EF_TS; pfam00889
637905003364	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
637905003365	putative nucleotide binding site [chemical binding]; other site
637905003366	uridine monophosphate binding site [chemical binding]; other site
637905003367	homohexameric interface [polypeptide binding]; other site
637905003368	ribosome recycling factor; Reviewed; Region: frr; PRK00083
637905003369	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
637905003370	hinge region; other site
637905003371	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
637905003372	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
637905003373	catalytic residue [active]
637905003374	putative FPP diphosphate  binding site; other site
637905003375	putative FPP binding hydrophobic cleft; other site
637905003376	dimer interface [polypeptide binding]; other site
637905003377	putative IPP diphosphate binding site; other site
637905003378	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
637905003379	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
637905003380	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
637905003381	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
637905003382	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
637905003383	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
637905003384	potential frameshift: common BLAST hit: gi|157376286|ref|YP_001474886.1|  membrane-associated zinc metalloprotease
637905003385	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
637905003386	active site
637905003387	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
637905003388	protein binding site [polypeptide binding]; other site
637905003389	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
637905003390	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
637905003391	putative substrate binding region [chemical binding]; other site
637905003392	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
637905003393	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
637905003394	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
637905003395	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
637905003396	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
637905003397	Surface antigen; Region: Bac_surface_Ag; pfam01103
637905003398	periplasmic chaperone; Provisional; Region: PRK10780
637905003399	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
637905003400	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
637905003401	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
637905003402	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
637905003403	trimer interface [polypeptide binding]; other site
637905003404	active site
637905003405	UDP-GlcNAc binding site [chemical binding]; other site
637905003406	lipid binding site [chemical binding]; lipid-binding site
637905003407	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
637905003408	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
637905003409	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
637905003410	active site
637905003411	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
637905003412	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
637905003413	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
637905003414	RNA/DNA hybrid binding site [nucleotide binding]; other site
637905003415	active site
637905003416	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
637905003417	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
637905003418	putative active site [active]
637905003419	putative PHP Thumb interface [polypeptide binding]; other site
637905003420	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
637905003421	generic binding surface II; other site
637905003422	generic binding surface I; other site
637905003423	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
637905003424	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
637905003425	Ligand Binding Site [chemical binding]; other site
637905003426	TilS substrate binding domain; Region: TilS; pfam09179
637905003427	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
637905003428	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905003429	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905003430	metal binding site [ion binding]; metal-binding site
637905003431	active site
637905003432	I-site; other site
637905003433	putative cation:proton antiport protein; Provisional; Region: PRK10669
637905003434	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
637905003435	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
637905003436	TrkA-N domain; Region: TrkA_N; pfam02254
637905003437	TrkA-C domain; Region: TrkA_C; pfam02080
637905003438	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
637905003439	active site
637905003440	catalytic triad [active]
637905003441	oxyanion hole [active]
637905003442	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
637905003443	NlpC/P60 family; Region: NLPC_P60; pfam00877
637905003444	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
637905003445	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
637905003446	active site
637905003447	nucleophile elbow; other site
637905003448	prolyl-tRNA synthetase; Provisional; Region: PRK09194
637905003449	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
637905003450	dimer interface [polypeptide binding]; other site
637905003451	motif 1; other site
637905003452	active site
637905003453	motif 2; other site
637905003454	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
637905003455	putative deacylase active site [active]
637905003456	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
637905003457	active site
637905003458	motif 3; other site
637905003459	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
637905003460	anticodon binding site; other site
637905003461	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
637905003462	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
637905003463	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
637905003464	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
637905003465	putative trimer interface [polypeptide binding]; other site
637905003466	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
637905003467	putative CoA binding site [chemical binding]; other site
637905003468	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
637905003469	trimer interface [polypeptide binding]; other site
637905003470	active site
637905003471	substrate binding site [chemical binding]; other site
637905003472	CoA binding site [chemical binding]; other site
637905003473	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
637905003474	homodimer interaction site [polypeptide binding]; other site
637905003475	cofactor binding site; other site
637905003476	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
637905003477	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
637905003478	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
637905003479	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
637905003480	Ligand binding site [chemical binding]; other site
637905003481	Electron transfer flavoprotein domain; Region: ETF; pfam01012
637905003482	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
637905003483	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
637905003484	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
637905003485	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
637905003486	thymidine kinase; Provisional; Region: PRK04296
637905003487	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
637905003488	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
637905003489	catalytic residues [active]
637905003490	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
637905003491	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
637905003492	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
637905003493	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
637905003494	active site
637905003495	catalytic residues [active]
637905003496	metal binding site [ion binding]; metal-binding site
637905003497	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
637905003498	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
637905003499	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
637905003500	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
637905003501	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
637905003502	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
637905003503	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
637905003504	carboxyltransferase (CT) interaction site; other site
637905003505	biotinylation site [posttranslational modification]; other site
637905003506	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
637905003507	gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674
637905003508	substrate binding site [chemical binding]; other site
637905003509	oxyanion hole (OAH) forming residues; other site
637905003510	trimer interface [polypeptide binding]; other site
637905003511	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
637905003512	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
637905003513	isovaleryl-CoA dehydrogenase; Region: PLN02519
637905003514	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
637905003515	substrate binding site [chemical binding]; other site
637905003516	FAD binding site [chemical binding]; other site
637905003517	catalytic base [active]
637905003518	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
637905003519	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
637905003520	DNA binding residues [nucleotide binding]
637905003521	putative dimer interface [polypeptide binding]; other site
637905003522	Helix-turn-helix domain; Region: HTH_18; pfam12833
637905003523	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
637905003524	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
637905003525	Enoate reductase (ER)-like FMN-binding domain. Enoate reductase catalyzes the NADH-dependent reduction of carbon-carbon double bonds of several molecules, including nonactivated 2-enoates, alpha,beta-unsaturated aldehydes, cyclic ketones, and...; Region: ER_like_FMN; cd02931
637905003526	putative active site [active]
637905003527	putative FMN binding site [chemical binding]; other site
637905003528	putative substrate binding site [chemical binding]; other site
637905003529	putative catalytic residue [active]
637905003530	putative 4Fe-4S cluster binding site [ion binding]; other site
637905003531	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
637905003532	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
637905003533	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
637905003534	FMN binding site [chemical binding]; other site
637905003535	active site
637905003536	substrate binding site [chemical binding]; other site
637905003537	catalytic residue [active]
637905003538	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905003539	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905003540	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
637905003541	putative effector binding pocket; other site
637905003542	dimerization interface [polypeptide binding]; other site
637905003543	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
637905003544	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
637905003545	TrkA-N domain; Region: TrkA_N; pfam02254
637905003546	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
637905003547	Global regulator protein family; Region: CsrA; cl00670
637905003548	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
637905003549	heme-binding site [chemical binding]; other site
637905003550	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782
637905003551	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
637905003552	PhnA protein; Region: PhnA; pfam03831
637905003553	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
637905003554	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
637905003555	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
637905003556	Domain of unknown function (DUF3291); Region: DUF3291; pfam11695
637905003557	potential frameshift: common BLAST hit: gi|157374494|ref|YP_001473094.1| sodium-glutamate symporter
637905003558	Sodium/glutamate symporter; Region: Glt_symporter; pfam03616
637905003559	potential frameshift: common BLAST hit: gi|212636349|ref|YP_002312874.1| Glutamate permease
637905003560	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
637905003561	potential frameshift: common BLAST hit: gi|157374494|ref|YP_001473094.1| sodium-glutamate symporter
637905003562	Sodium/glutamate symporter; Region: Glt_symporter; pfam03616
637905003563	Sodium/glutamate symporter; Region: Glt_symporter; pfam03616
637905003564	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_27; cd04686
637905003565	nudix motif; other site
637905003566	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
637905003567	hypothetical protein; Provisional; Region: PRK11038
637905003568	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
637905003569	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
637905003570	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
637905003571	classical (c) SDRs; Region: SDR_c; cd05233
637905003572	NAD(P) binding site [chemical binding]; other site
637905003573	active site
637905003574	Predicted transcriptional regulators [Transcription]; Region: COG1733
637905003575	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
637905003576	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
637905003577	putative active site [active]
637905003578	PAS fold; Region: PAS_3; pfam08447
637905003579	heme pocket [chemical binding]; other site
637905003580	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905003581	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905003582	metal binding site [ion binding]; metal-binding site
637905003583	active site
637905003584	I-site; other site
637905003585	YecR-like lipoprotein; Region: YecR; cl10256
637905003586	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
637905003587	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
637905003588	active site
637905003589	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
637905003590	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
637905003591	substrate binding pocket [chemical binding]; other site
637905003592	membrane-bound complex binding site; other site
637905003593	hinge residues; other site
637905003594	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
637905003595	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905003596	N-terminal plug; other site
637905003597	ligand-binding site [chemical binding]; other site
637905003598	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
637905003599	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
637905003600	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
637905003601	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
637905003602	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
637905003603	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
637905003604	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
637905003605	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
637905003606	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
637905003607	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
637905003608	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905003609	dimerization interface [polypeptide binding]; other site
637905003610	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
637905003611	PAS domain; Region: PAS_9; pfam13426
637905003612	putative active site [active]
637905003613	heme pocket [chemical binding]; other site
637905003614	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
637905003615	dimer interface [polypeptide binding]; other site
637905003616	phosphorylation site [posttranslational modification]
637905003617	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905003618	ATP binding site [chemical binding]; other site
637905003619	Mg2+ binding site [ion binding]; other site
637905003620	G-X-G motif; other site
637905003621	Response regulator receiver domain; Region: Response_reg; pfam00072
637905003622	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905003623	active site
637905003624	phosphorylation site [posttranslational modification]
637905003625	intermolecular recognition site; other site
637905003626	dimerization interface [polypeptide binding]; other site
637905003627	Response regulator receiver domain; Region: Response_reg; pfam00072
637905003628	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905003629	active site
637905003630	phosphorylation site [posttranslational modification]
637905003631	intermolecular recognition site; other site
637905003632	dimerization interface [polypeptide binding]; other site
637905003633	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
637905003634	putative binding surface; other site
637905003635	active site
637905003636	Response regulator receiver domain; Region: Response_reg; pfam00072
637905003637	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905003638	active site
637905003639	phosphorylation site [posttranslational modification]
637905003640	intermolecular recognition site; other site
637905003641	dimerization interface [polypeptide binding]; other site
637905003642	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905003643	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905003644	metal binding site [ion binding]; metal-binding site
637905003645	active site
637905003646	I-site; other site
637905003647	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
637905003648	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905003649	active site
637905003650	phosphorylation site [posttranslational modification]
637905003651	intermolecular recognition site; other site
637905003652	dimerization interface [polypeptide binding]; other site
637905003653	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
637905003654	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
637905003655	Predicted membrane protein [Function unknown]; Region: COG2259
637905003656	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
637905003657	FOG: CBS domain [General function prediction only]; Region: COG0517
637905003658	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
637905003659	Protein of unknown function (DUF2787); Region: DUF2787; pfam10980
637905003660	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
637905003661	MPN+ (JAMM) motif; other site
637905003662	Zinc-binding site [ion binding]; other site
637905003663	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
637905003664	cell division protein FtsZ; Validated; Region: PRK09330
637905003665	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
637905003666	nucleotide binding site [chemical binding]; other site
637905003667	SulA interaction site; other site
637905003668	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
637905003669	putative DNA binding helix; other site
637905003670	WYL domain; Region: WYL; pfam13280
637905003671	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
637905003672	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905003673	Walker A motif; other site
637905003674	ATP binding site [chemical binding]; other site
637905003675	Walker B motif; other site
637905003676	arginine finger; other site
637905003677	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
637905003678	regulatory ATPase RavA; Provisional; Region: PRK13531
637905003679	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905003680	Walker A motif; other site
637905003681	ATP binding site [chemical binding]; other site
637905003682	Walker B motif; other site
637905003683	arginine finger; other site
637905003684	hypothetical protein; Provisional; Region: yieM; PRK10997
637905003685	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
637905003686	metal ion-dependent adhesion site (MIDAS); other site
637905003687	Helix-turn-helix domain; Region: HTH_17; pfam12728
637905003688	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
637905003689	SmpB-tmRNA interface; other site
637905003690	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
637905003691	putative coenzyme Q binding site [chemical binding]; other site
637905003692	hypothetical protein; Validated; Region: PRK01777
637905003693	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
637905003694	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
637905003695	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
637905003696	active site
637905003697	SAM binding site [chemical binding]; other site
637905003698	homodimer interface [polypeptide binding]; other site
637905003699	Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673
637905003700	Tetratricopeptide repeat; Region: TPR_12; pfam13424
637905003701	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905003702	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905003703	metal binding site [ion binding]; metal-binding site
637905003704	active site
637905003705	I-site; other site
637905003706	HDOD domain; Region: HDOD; pfam08668
637905003707	GAF domain; Region: GAF_3; pfam13492
637905003708	SnoaL-like domain; Region: SnoaL_3; pfam13474
637905003709	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
637905003710	ParA-like protein; Provisional; Region: PHA02518
637905003711	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
637905003712	P-loop; other site
637905003713	Magnesium ion binding site [ion binding]; other site
637905003714	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
637905003715	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
637905003716	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637905003717	Coenzyme A binding pocket [chemical binding]; other site
637905003718	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
637905003719	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
637905003720	active site
637905003721	metal binding site [ion binding]; metal-binding site
637905003722	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
637905003723	Domain of unknown function DUF21; Region: DUF21; pfam01595
637905003724	FOG: CBS domain [General function prediction only]; Region: COG0517
637905003725	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
637905003726	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
637905003727	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637905003728	FeS/SAM binding site; other site
637905003729	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
637905003730	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905003731	binding surface
637905003732	TPR motif; other site
637905003733	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905003734	binding surface
637905003735	TPR motif; other site
637905003736	cytoskeletal protein RodZ; Provisional; Region: PRK10856
637905003737	Helix-turn-helix domain; Region: HTH_25; pfam13413
637905003738	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
637905003739	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
637905003740	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
637905003741	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
637905003742	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
637905003743	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
637905003744	dimer interface [polypeptide binding]; other site
637905003745	motif 1; other site
637905003746	active site
637905003747	motif 2; other site
637905003748	motif 3; other site
637905003749	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
637905003750	anticodon binding site; other site
637905003751	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
637905003752	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
637905003753	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
637905003754	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
637905003755	Trp docking motif [polypeptide binding]; other site
637905003756	active site
637905003757	GTP-binding protein Der; Reviewed; Region: PRK00093
637905003758	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
637905003759	G1 box; other site
637905003760	GTP/Mg2+ binding site [chemical binding]; other site
637905003761	Switch I region; other site
637905003762	G2 box; other site
637905003763	Switch II region; other site
637905003764	G3 box; other site
637905003765	G4 box; other site
637905003766	G5 box; other site
637905003767	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
637905003768	G1 box; other site
637905003769	GTP/Mg2+ binding site [chemical binding]; other site
637905003770	Switch I region; other site
637905003771	G2 box; other site
637905003772	G3 box; other site
637905003773	Switch II region; other site
637905003774	G4 box; other site
637905003775	G5 box; other site
637905003776	potential frameshift: common BLAST hit: gi|170725913|ref|YP_001759939.1| exodeoxyribonuclease VII large subunit
637905003777	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
637905003778	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
637905003779	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
637905003780	generic binding surface II; other site
637905003781	generic binding surface I; other site
637905003782	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
637905003783	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
637905003784	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
637905003785	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
637905003786	active site
637905003787	GMP synthase; Reviewed; Region: guaA; PRK00074
637905003788	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
637905003789	AMP/PPi binding site [chemical binding]; other site
637905003790	candidate oxyanion hole; other site
637905003791	catalytic triad [active]
637905003792	potential glutamine specificity residues [chemical binding]; other site
637905003793	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
637905003794	ATP Binding subdomain [chemical binding]; other site
637905003795	Ligand Binding sites [chemical binding]; other site
637905003796	Dimerization subdomain; other site
637905003797	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
637905003798	nucleoside/Zn binding site; other site
637905003799	dimer interface [polypeptide binding]; other site
637905003800	catalytic motif [active]
637905003801	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
637905003802	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
637905003803	substrate binding pocket [chemical binding]; other site
637905003804	membrane-bound complex binding site; other site
637905003805	hinge residues; other site
637905003806	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
637905003807	N-acetyl-D-glucosamine binding site [chemical binding]; other site
637905003808	catalytic residue [active]
637905003809	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
637905003810	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
637905003811	dimerization interface [polypeptide binding]; other site
637905003812	ATP binding site [chemical binding]; other site
637905003813	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
637905003814	dimerization interface [polypeptide binding]; other site
637905003815	ATP binding site [chemical binding]; other site
637905003816	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
637905003817	putative active site [active]
637905003818	catalytic triad [active]
637905003819	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
637905003820	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
637905003821	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
637905003822	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
637905003823	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
637905003824	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
637905003825	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
637905003826	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637905003827	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905003828	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
637905003829	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
637905003830	Protein of unknown function (DUF2947); Region: DUF2947; pfam11163
637905003831	HNH endonuclease; Region: HNH_2; pfam13391
637905003832	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
637905003833	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905003834	N-terminal plug; other site
637905003835	ligand-binding site [chemical binding]; other site
637905003836	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
637905003837	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
637905003838	LPP20 lipoprotein; Region: LPP20; pfam02169
637905003839	FlgN protein; Region: FlgN; pfam05130
637905003840	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
637905003841	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
637905003842	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
637905003843	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
637905003844	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
637905003845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905003846	active site
637905003847	phosphorylation site [posttranslational modification]
637905003848	intermolecular recognition site; other site
637905003849	dimerization interface [polypeptide binding]; other site
637905003850	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
637905003851	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
637905003852	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905003853	S-adenosylmethionine binding site [chemical binding]; other site
637905003854	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12625
637905003855	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
637905003856	flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12631
637905003857	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
637905003858	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
637905003859	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
637905003860	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
637905003861	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
637905003862	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
637905003863	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
637905003864	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
637905003865	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
637905003866	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
637905003867	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
637905003868	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
637905003869	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
637905003870	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
637905003871	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
637905003872	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
637905003873	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
637905003874	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
637905003875	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
637905003876	Flagellar L-ring protein; Region: FlgH; pfam02107
637905003877	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
637905003878	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
637905003879	Rod binding protein; Region: Rod-binding; cl01626
637905003880	flagellar rod assembly protein/muramidase FlgJ; Region: flagell_FlgJ; TIGR02541
637905003881	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
637905003882	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08871
637905003883	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
637905003884	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
637905003885	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
637905003886	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
637905003887	flagellin; Provisional; Region: PRK12806
637905003888	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
637905003889	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
637905003890	flagellin; Provisional; Region: PRK12806
637905003891	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
637905003892	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
637905003893	FlaG protein; Region: FlaG; pfam03646
637905003894	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
637905003895	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
637905003896	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
637905003897	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
637905003898	flagellar protein FliS; Validated; Region: fliS; PRK05685
637905003899	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
637905003900	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
637905003901	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905003902	Walker A motif; other site
637905003903	ATP binding site [chemical binding]; other site
637905003904	Walker B motif; other site
637905003905	arginine finger; other site
637905003906	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
637905003907	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
637905003908	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
637905003909	dimer interface [polypeptide binding]; other site
637905003910	phosphorylation site [posttranslational modification]
637905003911	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905003912	ATP binding site [chemical binding]; other site
637905003913	Mg2+ binding site [ion binding]; other site
637905003914	G-X-G motif; other site
637905003915	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
637905003916	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905003917	active site
637905003918	phosphorylation site [posttranslational modification]
637905003919	intermolecular recognition site; other site
637905003920	dimerization interface [polypeptide binding]; other site
637905003921	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905003922	Walker A motif; other site
637905003923	ATP binding site [chemical binding]; other site
637905003924	Walker B motif; other site
637905003925	arginine finger; other site
637905003926	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
637905003927	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
637905003928	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
637905003929	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
637905003930	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
637905003931	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
637905003932	MgtE intracellular N domain; Region: MgtE_N; smart00924
637905003933	FliG C-terminal domain; Region: FliG_C; pfam01706
637905003934	flagellar assembly protein H; Validated; Region: fliH; PRK05687
637905003935	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
637905003936	Flagellar assembly protein FliH; Region: FliH; pfam02108
637905003937	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08972
637905003938	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
637905003939	Walker A motif/ATP binding site; other site
637905003940	Walker B motif; other site
637905003941	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
637905003942	Flagellar FliJ protein; Region: FliJ; pfam02050
637905003943	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
637905003944	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
637905003945	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696
637905003946	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
637905003947	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
637905003948	flagellar motor switch protein; Validated; Region: fliN; PRK08983
637905003949	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
637905003950	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
637905003951	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
637905003952	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
637905003953	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
637905003954	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
637905003955	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
637905003956	FHIPEP family; Region: FHIPEP; pfam00771
637905003957	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
637905003958	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
637905003959	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
637905003960	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
637905003961	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
637905003962	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
637905003963	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
637905003964	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
637905003965	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
637905003966	DNA binding residues [nucleotide binding]
637905003967	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
637905003968	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905003969	active site
637905003970	phosphorylation site [posttranslational modification]
637905003971	intermolecular recognition site; other site
637905003972	dimerization interface [polypeptide binding]; other site
637905003973	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
637905003974	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
637905003975	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
637905003976	putative binding surface; other site
637905003977	active site
637905003978	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
637905003979	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905003980	ATP binding site [chemical binding]; other site
637905003981	Mg2+ binding site [ion binding]; other site
637905003982	G-X-G motif; other site
637905003983	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
637905003984	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
637905003985	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905003986	active site
637905003987	phosphorylation site [posttranslational modification]
637905003988	intermolecular recognition site; other site
637905003989	dimerization interface [polypeptide binding]; other site
637905003990	CheB methylesterase; Region: CheB_methylest; pfam01339
637905003991	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
637905003992	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
637905003993	P-loop; other site
637905003994	Magnesium ion binding site [ion binding]; other site
637905003995	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
637905003996	Magnesium ion binding site [ion binding]; other site
637905003997	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
637905003998	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
637905003999	putative CheA interaction surface; other site
637905004000	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
637905004001	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
637905004002	VacJ like lipoprotein; Region: VacJ; cl01073
637905004003	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905004004	Response regulator receiver domain; Region: Response_reg; pfam00072
637905004005	active site
637905004006	phosphorylation site [posttranslational modification]
637905004007	intermolecular recognition site; other site
637905004008	dimerization interface [polypeptide binding]; other site
637905004009	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
637905004010	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905004011	putative substrate translocation pore; other site
637905004012	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
637905004013	transcriptional activator RfaH; Region: RfaH; TIGR01955
637905004014	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
637905004015	heterodimer interface [polypeptide binding]; other site
637905004016	homodimer interface [polypeptide binding]; other site
637905004017	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
637905004018	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
637905004019	SLBB domain; Region: SLBB; pfam10531
637905004020	SLBB domain; Region: SLBB; pfam10531
637905004021	SLBB domain; Region: SLBB; pfam10531
637905004022	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
637905004023	SLBB domain; Region: SLBB; pfam10531
637905004024	Chain length determinant protein; Region: Wzz; pfam02706
637905004025	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
637905004026	nudix motif; other site
637905004027	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
637905004028	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
637905004029	Substrate binding site; other site
637905004030	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
637905004031	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
637905004032	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
637905004033	active site
637905004034	substrate binding site [chemical binding]; other site
637905004035	metal binding site [ion binding]; metal-binding site
637905004036	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
637905004037	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
637905004038	NADP-binding site; other site
637905004039	homotetramer interface [polypeptide binding]; other site
637905004040	substrate binding site [chemical binding]; other site
637905004041	homodimer interface [polypeptide binding]; other site
637905004042	active site
637905004043	potential frameshift: common BLAST hit: gi|54303386|ref|YP_133379.1| transposase
637905004044	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
637905004045	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
637905004046	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
637905004047	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
637905004048	active site
637905004049	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
637905004050	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
637905004051	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
637905004052	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
637905004053	NADP-binding site; other site
637905004054	homotetramer interface [polypeptide binding]; other site
637905004055	substrate binding site [chemical binding]; other site
637905004056	homodimer interface [polypeptide binding]; other site
637905004057	active site
637905004058	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
637905004059	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
637905004060	NADP-binding site; other site
637905004061	homotetramer interface [polypeptide binding]; other site
637905004062	substrate binding site [chemical binding]; other site
637905004063	homodimer interface [polypeptide binding]; other site
637905004064	active site
637905004065	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
637905004066	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
637905004067	NADP binding site [chemical binding]; other site
637905004068	active site
637905004069	putative substrate binding site [chemical binding]; other site
637905004070	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
637905004071	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
637905004072	NAD binding site [chemical binding]; other site
637905004073	substrate binding site [chemical binding]; other site
637905004074	homodimer interface [polypeptide binding]; other site
637905004075	active site
637905004076	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
637905004077	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
637905004078	substrate binding site; other site
637905004079	tetramer interface; other site
637905004080	WxcM-like, C-terminal; Region: FdtA; pfam05523
637905004081	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
637905004082	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
637905004083	putative trimer interface [polypeptide binding]; other site
637905004084	putative active site [active]
637905004085	putative substrate binding site [chemical binding]; other site
637905004086	putative CoA binding site [chemical binding]; other site
637905004087	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
637905004088	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
637905004089	inhibitor-cofactor binding pocket; inhibition site
637905004090	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905004091	catalytic residue [active]
637905004092	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
637905004093	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
637905004094	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
637905004095	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
637905004096	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
637905004097	active site
637905004098	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
637905004099	metal-binding site
637905004100	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
637905004101	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
637905004102	NAD(P) binding site [chemical binding]; other site
637905004103	active site
637905004104	Bacterial sugar transferase; Region: Bac_transf; pfam02397
637905004105	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
637905004106	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
637905004107	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
637905004108	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
637905004109	putative NAD(P) binding site [chemical binding]; other site
637905004110	active site
637905004111	putative substrate binding site [chemical binding]; other site
637905004112	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
637905004113	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
637905004114	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
637905004115	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
637905004116	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
637905004117	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
637905004118	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
637905004119	NAD(P) binding site [chemical binding]; other site
637905004120	homodimer interface [polypeptide binding]; other site
637905004121	substrate binding site [chemical binding]; other site
637905004122	active site
637905004123	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
637905004124	active site
637905004125	tetramer interface; other site
637905004126	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
637905004127	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
637905004128	Active Sites [active]
637905004129	hypothetical protein; Reviewed; Region: PRK12275
637905004130	four helix bundle protein; Region: TIGR02436
637905004131	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
637905004132	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
637905004133	CysD dimerization site [polypeptide binding]; other site
637905004134	G1 box; other site
637905004135	putative GEF interaction site [polypeptide binding]; other site
637905004136	GTP/Mg2+ binding site [chemical binding]; other site
637905004137	Switch I region; other site
637905004138	G2 box; other site
637905004139	G3 box; other site
637905004140	Switch II region; other site
637905004141	G4 box; other site
637905004142	G5 box; other site
637905004143	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
637905004144	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
637905004145	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
637905004146	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
637905004147	TrkA-C domain; Region: TrkA_C; pfam02080
637905004148	TrkA-C domain; Region: TrkA_C; pfam02080
637905004149	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
637905004150	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
637905004151	ligand-binding site [chemical binding]; other site
637905004152	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
637905004153	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
637905004154	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
637905004155	active site
637905004156	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
637905004157	putative trimer interface [polypeptide binding]; other site
637905004158	putative CoA binding site [chemical binding]; other site
637905004159	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
637905004160	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
637905004161	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
637905004162	Bacterial sugar transferase; Region: Bac_transf; pfam02397
637905004163	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
637905004164	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
637905004165	active site
637905004166	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
637905004167	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
637905004168	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
637905004169	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
637905004170	anti sigma factor interaction site; other site
637905004171	regulatory phosphorylation site [posttranslational modification]; other site
637905004172	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
637905004173	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
637905004174	ATP binding site [chemical binding]; other site
637905004175	Mg2+ binding site [ion binding]; other site
637905004176	G-X-G motif; other site
637905004177	Response regulator receiver domain; Region: Response_reg; pfam00072
637905004178	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905004179	active site
637905004180	phosphorylation site [posttranslational modification]
637905004181	intermolecular recognition site; other site
637905004182	dimerization interface [polypeptide binding]; other site
637905004183	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
637905004184	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
637905004185	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905004186	dimerization interface [polypeptide binding]; other site
637905004187	PAS domain S-box; Region: sensory_box; TIGR00229
637905004188	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
637905004189	putative active site [active]
637905004190	heme pocket [chemical binding]; other site
637905004191	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
637905004192	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
637905004193	putative active site [active]
637905004194	heme pocket [chemical binding]; other site
637905004195	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
637905004196	dimer interface [polypeptide binding]; other site
637905004197	phosphorylation site [posttranslational modification]
637905004198	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905004199	ATP binding site [chemical binding]; other site
637905004200	Mg2+ binding site [ion binding]; other site
637905004201	G-X-G motif; other site
637905004202	Response regulator receiver domain; Region: Response_reg; pfam00072
637905004203	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905004204	active site
637905004205	phosphorylation site [posttranslational modification]
637905004206	intermolecular recognition site; other site
637905004207	dimerization interface [polypeptide binding]; other site
637905004208	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
637905004209	putative binding surface; other site
637905004210	active site
637905004211	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
637905004212	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905004213	active site
637905004214	phosphorylation site [posttranslational modification]
637905004215	intermolecular recognition site; other site
637905004216	dimerization interface [polypeptide binding]; other site
637905004217	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905004218	Walker A motif; other site
637905004219	ATP binding site [chemical binding]; other site
637905004220	Walker B motif; other site
637905004221	arginine finger; other site
637905004222	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
637905004223	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
637905004224	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
637905004225	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
637905004226	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
637905004227	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
637905004228	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905004229	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905004230	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905004231	Transcriptional regulators [Transcription]; Region: PurR; COG1609
637905004232	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
637905004233	DNA binding site [nucleotide binding]
637905004234	domain linker motif; other site
637905004235	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
637905004236	dimerization interface (closed form) [polypeptide binding]; other site
637905004237	ligand binding site [chemical binding]; other site
637905004238	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
637905004239	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
637905004240	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
637905004241	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
637905004242	beta-galactosidase; Region: BGL; TIGR03356
637905004243	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
637905004244	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905004245	putative substrate translocation pore; other site
637905004246	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905004247	fructokinase; Reviewed; Region: PRK09557
637905004248	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
637905004249	nucleotide binding site [chemical binding]; other site
637905004250	Uncharacterized conserved protein [Function unknown]; Region: COG1434
637905004251	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
637905004252	putative active site [active]
637905004253	Protein of unknown function (DUF2982); Region: DUF2982; pfam11201
637905004254	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
637905004255	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
637905004256	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
637905004257	UDP-glucose 4-epimerase; Region: PLN02240
637905004258	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
637905004259	NAD binding site [chemical binding]; other site
637905004260	homodimer interface [polypeptide binding]; other site
637905004261	active site
637905004262	substrate binding site [chemical binding]; other site
637905004263	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
637905004264	active site
637905004265	tetramer interface; other site
637905004266	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
637905004267	cofactor binding site; other site
637905004268	metal binding site [ion binding]; metal-binding site
637905004269	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
637905004270	aromatic arch; other site
637905004271	DCoH dimer interaction site [polypeptide binding]; other site
637905004272	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
637905004273	DCoH tetramer interaction site [polypeptide binding]; other site
637905004274	substrate binding site [chemical binding]; other site
637905004275	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
637905004276	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
637905004277	putative aromatic amino acid binding site; other site
637905004278	PAS domain; Region: PAS; smart00091
637905004279	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905004280	Walker A motif; other site
637905004281	ATP binding site [chemical binding]; other site
637905004282	Walker B motif; other site
637905004283	arginine finger; other site
637905004284	GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508
637905004285	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
637905004286	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
637905004287	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
637905004288	maleylacetoacetate isomerase; Region: maiA; TIGR01262
637905004289	C-terminal domain interface [polypeptide binding]; other site
637905004290	GSH binding site (G-site) [chemical binding]; other site
637905004291	putative dimer interface [polypeptide binding]; other site
637905004292	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
637905004293	dimer interface [polypeptide binding]; other site
637905004294	N-terminal domain interface [polypeptide binding]; other site
637905004295	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
637905004296	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
637905004297	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905004298	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905004299	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
637905004300	dimerization interface [polypeptide binding]; other site
637905004301	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905004302	Major Facilitator Superfamily; Region: MFS_1; pfam07690
637905004303	putative substrate translocation pore; other site
637905004304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905004305	Major Facilitator Superfamily; Region: MFS_1; pfam07690
637905004306	putative substrate translocation pore; other site
637905004307	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
637905004308	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
637905004309	active site
637905004310	HIGH motif; other site
637905004311	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
637905004312	active site
637905004313	KMSKS motif; other site
637905004314	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
637905004315	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
637905004316	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
637905004317	Walker A/P-loop; other site
637905004318	ATP binding site [chemical binding]; other site
637905004319	Q-loop/lid; other site
637905004320	ABC transporter signature motif; other site
637905004321	Walker B; other site
637905004322	D-loop; other site
637905004323	H-loop/switch region; other site
637905004324	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
637905004325	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
637905004326	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
637905004327	AlkA N-terminal domain; Region: AlkA_N; pfam06029
637905004328	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
637905004329	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
637905004330	minor groove reading motif; other site
637905004331	helix-hairpin-helix signature motif; other site
637905004332	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
637905004333	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
637905004334	DNA binding site [nucleotide binding]
637905004335	active site
637905004336	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
637905004337	DEAD-like helicases superfamily; Region: DEXDc; smart00487
637905004338	ATP binding site [chemical binding]; other site
637905004339	Mg++ binding site [ion binding]; other site
637905004340	motif III; other site
637905004341	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905004342	nucleotide binding region [chemical binding]; other site
637905004343	ATP-binding site [chemical binding]; other site
637905004344	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
637905004345	active site
637905004346	catalytic residues [active]
637905004347	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
637905004348	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
637905004349	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905004350	active site
637905004351	phosphorylation site [posttranslational modification]
637905004352	intermolecular recognition site; other site
637905004353	dimerization interface [polypeptide binding]; other site
637905004354	serine/threonine transporter SstT; Provisional; Region: PRK13628
637905004355	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
637905004356	OmpA family; Region: OmpA; pfam00691
637905004357	ligand binding site [chemical binding]; other site
637905004358	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
637905004359	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
637905004360	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
637905004361	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
637905004362	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
637905004363	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
637905004364	O-Antigen ligase; Region: Wzy_C; pfam04932
637905004365	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
637905004366	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
637905004367	SLBB domain; Region: SLBB; pfam10531
637905004368	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
637905004369	Chain length determinant protein; Region: Wzz; pfam02706
637905004370	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
637905004371	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
637905004372	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
637905004373	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
637905004374	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
637905004375	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
637905004376	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
637905004377	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
637905004378	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
637905004379	active site
637905004380	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
637905004381	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
637905004382	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
637905004383	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
637905004384	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
637905004385	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
637905004386	active site
637905004387	Protein of unknown function, DUF479; Region: DUF479; cl01203
637905004388	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
637905004389	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
637905004390	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
637905004391	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
637905004392	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
637905004393	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
637905004394	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
637905004395	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
637905004396	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
637905004397	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
637905004398	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
637905004399	Protein export membrane protein; Region: SecD_SecF; pfam02355
637905004400	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
637905004401	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
637905004402	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
637905004403	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
637905004404	YaeQ protein; Region: YaeQ; pfam07152
637905004405	probable metal-binding protein; Region: matur_matur; TIGR03853
637905004406	ParA-like protein; Provisional; Region: PHA02518
637905004407	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
637905004408	P-loop; other site
637905004409	Magnesium ion binding site [ion binding]; other site
637905004410	PilZ domain; Region: PilZ; pfam07238
637905004411	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
637905004412	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
637905004413	active site
637905004414	dimerization interface [polypeptide binding]; other site
637905004415	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
637905004416	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
637905004417	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
637905004418	serine O-acetyltransferase; Region: cysE; TIGR01172
637905004419	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
637905004420	trimer interface [polypeptide binding]; other site
637905004421	active site
637905004422	substrate binding site [chemical binding]; other site
637905004423	CoA binding site [chemical binding]; other site
637905004424	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
637905004425	Rrf2 family protein; Region: rrf2_super; TIGR00738
637905004426	cysteine desulfurase; Provisional; Region: PRK14012
637905004427	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
637905004428	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
637905004429	catalytic residue [active]
637905004430	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
637905004431	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
637905004432	trimerization site [polypeptide binding]; other site
637905004433	active site
637905004434	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
637905004435	co-chaperone HscB; Provisional; Region: hscB; PRK05014
637905004436	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
637905004437	HSP70 interaction site [polypeptide binding]; other site
637905004438	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
637905004439	chaperone protein HscA; Provisional; Region: hscA; PRK05183
637905004440	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
637905004441	nucleotide binding site [chemical binding]; other site
637905004442	putative NEF/HSP70 interaction site [polypeptide binding]; other site
637905004443	SBD interface [polypeptide binding]; other site
637905004444	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
637905004445	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
637905004446	catalytic loop [active]
637905004447	iron binding site [ion binding]; other site
637905004448	FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412
637905004449	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
637905004450	active site
637905004451	multimer interface [polypeptide binding]; other site
637905004452	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
637905004453	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905004454	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905004455	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
637905004456	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
637905004457	Helix-turn-helix domain; Region: HTH_18; pfam12833
637905004458	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
637905004459	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
637905004460	parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805
637905004461	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
637905004462	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
637905004463	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
637905004464	Protein of unknown function, DUF481; Region: DUF481; pfam04338
637905004465	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
637905004466	active site
637905004467	catalytic triad [active]
637905004468	oxyanion hole [active]
637905004469	switch loop; other site
637905004470	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
637905004471	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
637905004472	Walker A/P-loop; other site
637905004473	ATP binding site [chemical binding]; other site
637905004474	Q-loop/lid; other site
637905004475	ABC transporter signature motif; other site
637905004476	Walker B; other site
637905004477	D-loop; other site
637905004478	H-loop/switch region; other site
637905004479	FtsX-like permease family; Region: FtsX; pfam02687
637905004480	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
637905004481	hydrophobic ligand binding site; other site
637905004482	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
637905004483	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
637905004484	NAD(P) binding site [chemical binding]; other site
637905004485	active site
637905004486	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
637905004487	active site
637905004488	Domain of unknown function DUF20; Region: UPF0118; pfam01594
637905004489	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
637905004490	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
637905004491	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905004492	S-adenosylmethionine binding site [chemical binding]; other site
637905004493	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
637905004494	phosphate acetyltransferase; Reviewed; Region: PRK05632
637905004495	DRTGG domain; Region: DRTGG; pfam07085
637905004496	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
637905004497	propionate/acetate kinase; Provisional; Region: PRK12379
637905004498	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
637905004499	Protein of unknown function, DUF412; Region: DUF412; pfam04217
637905004500	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
637905004501	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637905004502	FeS/SAM binding site; other site
637905004503	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
637905004504	Pyruvate formate lyase 1; Region: PFL1; cd01678
637905004505	coenzyme A binding site [chemical binding]; other site
637905004506	active site
637905004507	catalytic residues [active]
637905004508	glycine loop; other site
637905004509	formate transporter FocA; Region: formate_focA; TIGR04060
637905004510	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
637905004511	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905004512	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
637905004513	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
637905004514	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
637905004515	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
637905004516	gating phenylalanine in ion channel; other site
637905004517	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
637905004518	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
637905004519	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
637905004520	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
637905004521	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
637905004522	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
637905004523	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
637905004524	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
637905004525	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
637905004526	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
637905004527	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
637905004528	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
637905004529	4Fe-4S binding domain; Region: Fer4; pfam00037
637905004530	4Fe-4S binding domain; Region: Fer4; pfam00037
637905004531	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
637905004532	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
637905004533	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
637905004534	catalytic loop [active]
637905004535	iron binding site [ion binding]; other site
637905004536	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
637905004537	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
637905004538	molybdopterin cofactor binding site; other site
637905004539	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
637905004540	molybdopterin cofactor binding site; other site
637905004541	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
637905004542	SLBB domain; Region: SLBB; pfam10531
637905004543	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
637905004544	NADH dehydrogenase subunit E; Validated; Region: PRK07539
637905004545	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
637905004546	putative dimer interface [polypeptide binding]; other site
637905004547	[2Fe-2S] cluster binding site [ion binding]; other site
637905004548	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
637905004549	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
637905004550	NADH dehydrogenase subunit D; Validated; Region: PRK06075
637905004551	NADH dehydrogenase subunit B; Validated; Region: PRK06411
637905004552	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
637905004553	FOG: CBS domain [General function prediction only]; Region: COG0517
637905004554	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629
637905004555	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
637905004556	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
637905004557	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
637905004558	dimer interface [polypeptide binding]; other site
637905004559	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905004560	catalytic residue [active]
637905004561	RDD family; Region: RDD; pfam06271
637905004562	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905004563	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
637905004564	active site
637905004565	phosphorylation site [posttranslational modification]
637905004566	intermolecular recognition site; other site
637905004567	dimerization interface [polypeptide binding]; other site
637905004568	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905004569	active site
637905004570	phosphorylation site [posttranslational modification]
637905004571	intermolecular recognition site; other site
637905004572	dimerization interface [polypeptide binding]; other site
637905004573	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905004574	metal binding site [ion binding]; metal-binding site
637905004575	active site
637905004576	I-site; other site
637905004577	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
637905004578	MarR family; Region: MarR; pfam01047
637905004579	MarR family; Region: MarR_2; cl17246
637905004580	conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001
637905004581	BCCT family transporter; Region: BCCT; cl00569
637905004582	choline dehydrogenase; Validated; Region: PRK02106
637905004583	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
637905004584	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
637905004585	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
637905004586	tetrameric interface [polypeptide binding]; other site
637905004587	NAD binding site [chemical binding]; other site
637905004588	catalytic residues [active]
637905004589	transcriptional regulator BetI; Validated; Region: PRK00767
637905004590	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
637905004591	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
637905004592	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618
637905004593	putative ligand binding site [chemical binding]; other site
637905004594	Probable zinc-binding domain; Region: zf-trcl; pfam13451
637905004595	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
637905004596	active site
637905004597	metal binding site [ion binding]; metal-binding site
637905004598	putative sulfate transport protein CysZ; Validated; Region: PRK04949
637905004599	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
637905004600	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
637905004601	Walker A/P-loop; other site
637905004602	ATP binding site [chemical binding]; other site
637905004603	Q-loop/lid; other site
637905004604	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
637905004605	ABC transporter signature motif; other site
637905004606	Walker B; other site
637905004607	D-loop; other site
637905004608	H-loop/switch region; other site
637905004609	cell division protein ZipA; Provisional; Region: PRK03427
637905004610	GET complex subunit GET2; Region: GET2; pfam08690
637905004611	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
637905004612	FtsZ protein binding site [polypeptide binding]; other site
637905004613	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
637905004614	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
637905004615	nucleotide binding pocket [chemical binding]; other site
637905004616	K-X-D-G motif; other site
637905004617	catalytic site [active]
637905004618	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
637905004619	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
637905004620	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
637905004621	Dimer interface [polypeptide binding]; other site
637905004622	BRCT sequence motif; other site
637905004623	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
637905004624	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
637905004625	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
637905004626	Zn2+ binding site [ion binding]; other site
637905004627	Mg2+ binding site [ion binding]; other site
637905004628	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
637905004629	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
637905004630	putative NAD(P) binding site [chemical binding]; other site
637905004631	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
637905004632	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
637905004633	catalytic residues [active]
637905004634	hinge region; other site
637905004635	alpha helical domain; other site
637905004636	NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX...; Region: NOX_Duox_like_FAD_NADP; cd06186
637905004637	FAD binding pocket [chemical binding]; other site
637905004638	FAD binding motif [chemical binding]; other site
637905004639	NAD pyrophosphate binding region [chemical binding]; other site
637905004640	beta-alpha-beta stucture motif; other site
637905004641	NAD binding pocket [chemical binding]; other site
637905004642	NADP ribose binding motif [chemical binding]; other site
637905004643	DOMON-like domain of an uncharacterized protein family; Region: DOMON_like_cytochrome; cd09625
637905004644	putative ligand binding site [chemical binding]; other site
637905004645	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
637905004646	Predicted transcriptional regulators [Transcription]; Region: COG1733
637905004647	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
637905004648	dimerization interface [polypeptide binding]; other site
637905004649	putative DNA binding site [nucleotide binding]; other site
637905004650	putative Zn2+ binding site [ion binding]; other site
637905004651	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
637905004652	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
637905004653	NAD(P) binding site [chemical binding]; other site
637905004654	catalytic residues [active]
637905004655	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
637905004656	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
637905004657	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
637905004658	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
637905004659	active site
637905004660	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
637905004661	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
637905004662	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
637905004663	Na binding site [ion binding]; other site
637905004664	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
637905004665	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
637905004666	active site
637905004667	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
637905004668	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
637905004669	active site
637905004670	metal binding site [ion binding]; metal-binding site
637905004671	Bacterial Ig-like domain; Region: Big_5; pfam13205
637905004672	Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848
637905004673	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
637905004674	Interdomain contacts; other site
637905004675	Cytokine receptor motif; other site
637905004676	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
637905004677	Interdomain contacts; other site
637905004678	Cytokine receptor motif; other site
637905004679	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905004680	binding surface
637905004681	TPR motif; other site
637905004682	TPR repeat; Region: TPR_11; pfam13414
637905004683	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
637905004684	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
637905004685	ligand binding site [chemical binding]; other site
637905004686	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
637905004687	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
637905004688	metal binding triad; other site
637905004689	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
637905004690	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
637905004691	active site
637905004692	catalytic site [active]
637905004693	substrate binding site [chemical binding]; other site
637905004694	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
637905004695	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
637905004696	ligand binding site [chemical binding]; other site
637905004697	homodimer interface [polypeptide binding]; other site
637905004698	NAD(P) binding site [chemical binding]; other site
637905004699	trimer interface B [polypeptide binding]; other site
637905004700	trimer interface A [polypeptide binding]; other site
637905004701	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
637905004702	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
637905004703	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
637905004704	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
637905004705	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
637905004706	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
637905004707	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
637905004708	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
637905004709	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
637905004710	Cytochrome c; Region: Cytochrom_C; pfam00034
637905004711	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
637905004712	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
637905004713	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
637905004714	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
637905004715	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
637905004716	XdhC Rossmann domain; Region: XdhC_C; pfam13478
637905004717	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
637905004718	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879
637905004719	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
637905004720	dimer interface [polypeptide binding]; other site
637905004721	active site
637905004722	CoA binding pocket [chemical binding]; other site
637905004723	Transcriptional regulators [Transcription]; Region: GntR; COG1802
637905004724	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
637905004725	DNA-binding site [nucleotide binding]; DNA binding site
637905004726	FCD domain; Region: FCD; pfam07729
637905004727	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
637905004728	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
637905004729	dimer interface [polypeptide binding]; other site
637905004730	NADP binding site [chemical binding]; other site
637905004731	catalytic residues [active]
637905004732	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
637905004733	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
637905004734	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
637905004735	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
637905004736	inhibitor site; inhibition site
637905004737	active site
637905004738	dimer interface [polypeptide binding]; other site
637905004739	catalytic residue [active]
637905004740	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
637905004741	Proline racemase; Region: Pro_racemase; pfam05544
637905004742	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
637905004743	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
637905004744	hydroxyglutarate oxidase; Provisional; Region: PRK11728
637905004745	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
637905004746	FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244
637905004747	dimer interface [polypeptide binding]; other site
637905004748	Mn binding site [ion binding]; other site
637905004749	K binding site [ion binding]; other site
637905004750	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
637905004751	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
637905004752	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
637905004753	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
637905004754	HPP family; Region: HPP; pfam04982
637905004755	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
637905004756	proline aminopeptidase P II; Provisional; Region: PRK10879
637905004757	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
637905004758	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
637905004759	active site
637905004760	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
637905004761	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
637905004762	active site
637905004763	motif I; other site
637905004764	motif II; other site
637905004765	Domain of unknown function DUF11; Region: DUF11; pfam01345
637905004766	Domain of unknown function DUF11; Region: DUF11; cl17728
637905004767	Domain of unknown function DUF11; Region: DUF11; pfam01345
637905004768	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
637905004769	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
637905004770	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
637905004771	ligand binding site [chemical binding]; other site
637905004772	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
637905004773	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
637905004774	active site
637905004775	nucleophile elbow; other site
637905004776	hypothetical protein; Provisional; Region: PRK03641
637905004777	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
637905004778	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
637905004779	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
637905004780	Cl binding site [ion binding]; other site
637905004781	oligomer interface [polypeptide binding]; other site
637905004782	Protein of unknown function (DUF3135); Region: DUF3135; pfam11333
637905004783	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
637905004784	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
637905004785	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
637905004786	Zn2+ binding site [ion binding]; other site
637905004787	Mg2+ binding site [ion binding]; other site
637905004788	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
637905004789	sensor protein PhoQ; Provisional; Region: PRK10815
637905004790	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905004791	ATP binding site [chemical binding]; other site
637905004792	Mg2+ binding site [ion binding]; other site
637905004793	G-X-G motif; other site
637905004794	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
637905004795	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905004796	active site
637905004797	phosphorylation site [posttranslational modification]
637905004798	intermolecular recognition site; other site
637905004799	dimerization interface [polypeptide binding]; other site
637905004800	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637905004801	DNA binding site [nucleotide binding]
637905004802	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
637905004803	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
637905004804	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637905004805	Walker A/P-loop; other site
637905004806	ATP binding site [chemical binding]; other site
637905004807	ABC transporter signature motif; other site
637905004808	Walker B; other site
637905004809	D-loop; other site
637905004810	H-loop/switch region; other site
637905004811	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
637905004812	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
637905004813	LysE type translocator; Region: LysE; cl00565
637905004814	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
637905004815	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
637905004816	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
637905004817	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
637905004818	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
637905004819	homodimer interface [polypeptide binding]; other site
637905004820	NAD binding pocket [chemical binding]; other site
637905004821	ATP binding pocket [chemical binding]; other site
637905004822	Mg binding site [ion binding]; other site
637905004823	active-site loop [active]
637905004824	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
637905004825	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
637905004826	elongation factor P; Provisional; Region: PRK04542
637905004827	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
637905004828	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
637905004829	RNA binding site [nucleotide binding]; other site
637905004830	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
637905004831	RNA binding site [nucleotide binding]; other site
637905004832	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
637905004833	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
637905004834	Sulfatase; Region: Sulfatase; cl17466
637905004835	hypothetical protein; Provisional; Region: PRK13689
637905004836	Nucleoid-associated protein [General function prediction only]; Region: COG3081
637905004837	nucleoid-associated protein NdpA; Validated; Region: PRK00378
637905004838	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
637905004839	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
637905004840	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
637905004841	Peptidase family M23; Region: Peptidase_M23; pfam01551
637905004842	Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280
637905004843	Astacin (Peptidase family M12A); Region: Astacin; pfam01400
637905004844	active site
637905004845	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
637905004846	Interdomain contacts; other site
637905004847	Cytokine receptor motif; other site
637905004848	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
637905004849	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
637905004850	putative metal binding site [ion binding]; other site
637905004851	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
637905004852	Ion transport protein; Region: Ion_trans; pfam00520
637905004853	Ion channel; Region: Ion_trans_2; pfam07885
637905004854	Double zinc ribbon; Region: DZR; pfam12773
637905004855	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
637905004856	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
637905004857	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
637905004858	Protein of unknown function (DUF2986); Region: DUF2986; pfam11661
637905004859	murein transglycosylase A; Provisional; Region: mltA; PRK11162
637905004860	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
637905004861	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
637905004862	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
637905004863	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
637905004864	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
637905004865	hypothetical protein; Provisional; Region: PRK05713
637905004866	catalytic loop [active]
637905004867	iron binding site [ion binding]; other site
637905004868	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194
637905004869	FAD binding pocket [chemical binding]; other site
637905004870	FAD binding motif [chemical binding]; other site
637905004871	phosphate binding motif [ion binding]; other site
637905004872	beta-alpha-beta structure motif; other site
637905004873	NAD binding pocket [chemical binding]; other site
637905004874	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
637905004875	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
637905004876	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637905004877	Coenzyme A binding pocket [chemical binding]; other site
637905004878	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
637905004879	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
637905004880	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
637905004881	asparagine synthetase B; Provisional; Region: asnB; PRK09431
637905004882	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
637905004883	active site
637905004884	dimer interface [polypeptide binding]; other site
637905004885	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
637905004886	Ligand Binding Site [chemical binding]; other site
637905004887	Molecular Tunnel; other site
637905004888	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
637905004889	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
637905004890	PA/protease or protease-like domain interface [polypeptide binding]; other site
637905004891	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
637905004892	Peptidase family M28; Region: Peptidase_M28; pfam04389
637905004893	metal binding site [ion binding]; metal-binding site
637905004894	UMP phosphatase; Provisional; Region: PRK10444
637905004895	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
637905004896	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
637905004897	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
637905004898	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
637905004899	active site
637905004900	substrate binding site [chemical binding]; other site
637905004901	cosubstrate binding site; other site
637905004902	catalytic site [active]
637905004903	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
637905004904	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
637905004905	dimerization interface [polypeptide binding]; other site
637905004906	putative ATP binding site [chemical binding]; other site
637905004907	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
637905004908	active site
637905004909	Predicted permease [General function prediction only]; Region: COG2056
637905004910	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
637905004911	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322
637905004912	peroxidase; Provisional; Region: PRK15000
637905004913	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
637905004914	dimer interface [polypeptide binding]; other site
637905004915	decamer (pentamer of dimers) interface [polypeptide binding]; other site
637905004916	catalytic triad [active]
637905004917	peroxidatic and resolving cysteines [active]
637905004918	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
637905004919	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
637905004920	dimer interface [polypeptide binding]; other site
637905004921	catalytic site [active]
637905004922	putative active site [active]
637905004923	putative substrate binding site [chemical binding]; other site
637905004924	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
637905004925	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
637905004926	ligand binding site [chemical binding]; other site
637905004927	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
637905004928	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
637905004929	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
637905004930	active site
637905004931	TolQ protein; Region: tolQ; TIGR02796
637905004932	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
637905004933	TolR protein; Region: tolR; TIGR02801
637905004934	TolA protein; Region: tolA_full; TIGR02794
637905004935	TolA C-terminal; Region: TolA; pfam06519
637905004936	TolA protein; Region: tolA_full; TIGR02794
637905004937	translocation protein TolB; Provisional; Region: tolB; PRK04792
637905004938	TolB amino-terminal domain; Region: TolB_N; pfam04052
637905004939	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
637905004940	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
637905004941	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
637905004942	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
637905004943	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
637905004944	ligand binding site [chemical binding]; other site
637905004945	tol-pal system protein YbgF; Provisional; Region: PRK10803
637905004946	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905004947	binding surface
637905004948	TPR motif; other site
637905004949	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
637905004950	GSH binding site [chemical binding]; other site
637905004951	catalytic residues [active]
637905004952	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
637905004953	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
637905004954	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637905004955	ATP binding site [chemical binding]; other site
637905004956	putative Mg++ binding site [ion binding]; other site
637905004957	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905004958	nucleotide binding region [chemical binding]; other site
637905004959	ATP-binding site [chemical binding]; other site
637905004960	Double zinc ribbon; Region: DZR; pfam12773
637905004961	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
637905004962	acetyl-CoA synthetase; Provisional; Region: PRK00174
637905004963	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
637905004964	active site
637905004965	CoA binding site [chemical binding]; other site
637905004966	acyl-activating enzyme (AAE) consensus motif; other site
637905004967	AMP binding site [chemical binding]; other site
637905004968	acetate binding site [chemical binding]; other site
637905004969	potential frameshift: common BLAST hit: gi|157375003|ref|YP_001473603.1| integral membrane sensor hybrid histidine kinase
637905004970	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
637905004971	Na binding site [ion binding]; other site
637905004972	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
637905004973	PAS fold; Region: PAS_7; pfam12860
637905004974	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
637905004975	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
637905004976	dimer interface [polypeptide binding]; other site
637905004977	phosphorylation site [posttranslational modification]
637905004978	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905004979	ATP binding site [chemical binding]; other site
637905004980	Mg2+ binding site [ion binding]; other site
637905004981	G-X-G motif; other site
637905004982	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
637905004983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905004984	active site
637905004985	phosphorylation site [posttranslational modification]
637905004986	intermolecular recognition site; other site
637905004987	dimerization interface [polypeptide binding]; other site
637905004988	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
637905004989	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
637905004990	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
637905004991	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905004992	active site
637905004993	phosphorylation site [posttranslational modification]
637905004994	intermolecular recognition site; other site
637905004995	dimerization interface [polypeptide binding]; other site
637905004996	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
637905004997	DNA binding residues [nucleotide binding]
637905004998	dimerization interface [polypeptide binding]; other site
637905004999	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
637905005000	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
637905005001	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
637905005002	aromatic chitin/cellulose binding site residues [chemical binding]; other site
637905005003	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
637905005004	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
637905005005	active site
637905005006	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
637905005007	Chitinase C; Region: ChiC; pfam06483
637905005008	Cellulose-binding domain, chitinase and related proteins; Region: CBD_like; cd12204
637905005009	aromatic chitin/cellulose binding site residues [chemical binding]; other site
637905005010	ligand binding site [chemical binding]; other site
637905005011	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
637905005012	Glyco_18 domain; Region: Glyco_18; smart00636
637905005013	active site
637905005014	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
637905005015	aromatic chitin/cellulose binding site residues [chemical binding]; other site
637905005016	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
637905005017	aromatic chitin/cellulose binding site residues [chemical binding]; other site
637905005018	Chitin binding domain; Region: Chitin_bind_3; cl03871
637905005019	Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046
637905005020	aromatic chitin/cellulose binding site residues [chemical binding]; other site
637905005021	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
637905005022	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
637905005023	PEP synthetase regulatory protein; Provisional; Region: PRK05339
637905005024	phosphoenolpyruvate synthase; Validated; Region: PRK06464
637905005025	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
637905005026	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
637905005027	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
637905005028	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
637905005029	FAD binding domain; Region: FAD_binding_4; pfam01565
637905005030	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
637905005031	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
637905005032	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
637905005033	MarR family; Region: MarR; pfam01047
637905005034	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
637905005035	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
637905005036	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
637905005037	NAD binding site [chemical binding]; other site
637905005038	Phe binding site; other site
637905005039	Cupin superfamily protein; Region: Cupin_4; pfam08007
637905005040	Cupin domain; Region: Cupin_2; cl17218
637905005041	adenylosuccinate lyase; Provisional; Region: PRK09285
637905005042	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
637905005043	tetramer interface [polypeptide binding]; other site
637905005044	active site
637905005045	putative lysogenization regulator; Reviewed; Region: PRK00218
637905005046	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
637905005047	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
637905005048	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
637905005049	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
637905005050	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
637905005051	probable active site [active]
637905005052	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
637905005053	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
637905005054	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
637905005055	DNA-binding site [nucleotide binding]; DNA binding site
637905005056	RNA-binding motif; other site
637905005057	Uncharacterized conserved protein [Function unknown]; Region: COG2127
637905005058	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
637905005059	Clp amino terminal domain; Region: Clp_N; pfam02861
637905005060	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905005061	Walker A motif; other site
637905005062	ATP binding site [chemical binding]; other site
637905005063	Walker B motif; other site
637905005064	arginine finger; other site
637905005065	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905005066	Walker A motif; other site
637905005067	ATP binding site [chemical binding]; other site
637905005068	Walker B motif; other site
637905005069	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
637905005070	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
637905005071	rRNA binding site [nucleotide binding]; other site
637905005072	predicted 30S ribosome binding site; other site
637905005073	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
637905005074	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
637905005075	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
637905005076	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
637905005077	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
637905005078	Uncharacterized conserved protein [Function unknown]; Region: COG0327
637905005079	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
637905005080	Beta-lactamase; Region: Beta-lactamase; pfam00144
637905005081	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
637905005082	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
637905005083	conserved cys residue [active]
637905005084	cystathionine beta-lyase; Provisional; Region: PRK09028
637905005085	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
637905005086	homodimer interface [polypeptide binding]; other site
637905005087	substrate-cofactor binding pocket; other site
637905005088	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905005089	catalytic residue [active]
637905005090	proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785
637905005091	DOMON-like type 9 carbohydrate binding module at the N-terminus of bacterial sensor histidine kinases; Region: CBM9_like_HisKa; cd09622
637905005092	putative ligand binding site [chemical binding]; other site
637905005093	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
637905005094	dimer interface [polypeptide binding]; other site
637905005095	phosphorylation site [posttranslational modification]
637905005096	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905005097	ATP binding site [chemical binding]; other site
637905005098	Mg2+ binding site [ion binding]; other site
637905005099	G-X-G motif; other site
637905005100	proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787
637905005101	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905005102	active site
637905005103	phosphorylation site [posttranslational modification]
637905005104	intermolecular recognition site; other site
637905005105	dimerization interface [polypeptide binding]; other site
637905005106	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637905005107	DNA binding site [nucleotide binding]
637905005108	proteobacterial sortase system OmpA family protein; Region: pdsO; TIGR03789
637905005109	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
637905005110	ligand binding site [chemical binding]; other site
637905005111	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
637905005112	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
637905005113	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
637905005114	metal ion-dependent adhesion site (MIDAS); other site
637905005115	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
637905005116	active site
637905005117	catalytic site [active]
637905005118	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905005119	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905005120	metal binding site [ion binding]; metal-binding site
637905005121	active site
637905005122	I-site; other site
637905005123	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
637905005124	mce related protein; Region: MCE; pfam02470
637905005125	mce related protein; Region: MCE; pfam02470
637905005126	mce related protein; Region: MCE; pfam02470
637905005127	mce related protein; Region: MCE; pfam02470
637905005128	mce related protein; Region: MCE; pfam02470
637905005129	Paraquat-inducible protein A; Region: PqiA; pfam04403
637905005130	Paraquat-inducible protein A; Region: PqiA; pfam04403
637905005131	YebG protein; Region: YebG; pfam07130
637905005132	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
637905005133	GAF domain; Region: GAF_2; pfam13185
637905005134	ProP expression regulator; Provisional; Region: PRK04950
637905005135	ProQ/FINO family; Region: ProQ; smart00945
637905005136	carboxy-terminal protease; Provisional; Region: PRK11186
637905005137	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
637905005138	protein binding site [polypeptide binding]; other site
637905005139	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
637905005140	Catalytic dyad [active]
637905005141	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
637905005142	aminopeptidase N; Provisional; Region: pepN; PRK14015
637905005143	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
637905005144	active site
637905005145	Zn binding site [ion binding]; other site
637905005146	Protein of unknown function (DUF2835); Region: DUF2835; pfam11197
637905005147	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
637905005148	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
637905005149	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
637905005150	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
637905005151	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
637905005152	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
637905005153	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
637905005154	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
637905005155	quinone interaction residues [chemical binding]; other site
637905005156	active site
637905005157	catalytic residues [active]
637905005158	FMN binding site [chemical binding]; other site
637905005159	substrate binding site [chemical binding]; other site
637905005160	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
637905005161	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
637905005162	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
637905005163	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
637905005164	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
637905005165	putative RNA binding site [nucleotide binding]; other site
637905005166	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905005167	S-adenosylmethionine binding site [chemical binding]; other site
637905005168	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
637905005169	ABC transporter ATPase component; Reviewed; Region: PRK11147
637905005170	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
637905005171	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
637905005172	ABC transporter; Region: ABC_tran_2; pfam12848
637905005173	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
637905005174	Protein of unknown function (DUF3466); Region: DUF3466; pfam11949
637905005175	ribosome modulation factor; Provisional; Region: PRK14563
637905005176	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
637905005177	active site 1 [active]
637905005178	dimer interface [polypeptide binding]; other site
637905005179	active site 2 [active]
637905005180	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
637905005181	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
637905005182	response regulator; Provisional; Region: PRK09483
637905005183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905005184	active site
637905005185	phosphorylation site [posttranslational modification]
637905005186	intermolecular recognition site; other site
637905005187	dimerization interface [polypeptide binding]; other site
637905005188	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
637905005189	DNA binding residues [nucleotide binding]
637905005190	dimerization interface [polypeptide binding]; other site
637905005191	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
637905005192	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
637905005193	GIY-YIG motif/motif A; other site
637905005194	active site
637905005195	catalytic site [active]
637905005196	putative DNA binding site [nucleotide binding]; other site
637905005197	metal binding site [ion binding]; metal-binding site
637905005198	UvrB/uvrC motif; Region: UVR; pfam02151
637905005199	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
637905005200	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
637905005201	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
637905005202	active site
637905005203	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905005204	putative substrate translocation pore; other site
637905005205	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905005206	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905005207	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
637905005208	putative substrate translocation pore; other site
637905005209	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905005210	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905005211	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
637905005212	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
637905005213	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
637905005214	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
637905005215	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
637905005216	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
637905005217	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
637905005218	Peptidase M15; Region: Peptidase_M15_3; cl01194
637905005219	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
637905005220	5S rRNA interface [nucleotide binding]; other site
637905005221	CTC domain interface [polypeptide binding]; other site
637905005222	L16 interface [polypeptide binding]; other site
637905005223	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
637905005224	SpoVR family protein; Provisional; Region: PRK11767
637905005225	hypothetical protein; Provisional; Region: PRK05325
637905005226	PrkA family serine protein kinase; Provisional; Region: PRK15455
637905005227	AAA ATPase domain; Region: AAA_16; pfam13191
637905005228	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
637905005229	superoxide dismutase; Provisional; Region: PRK10543
637905005230	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
637905005231	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
637905005232	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
637905005233	putative GSH binding site [chemical binding]; other site
637905005234	catalytic residues [active]
637905005235	uracil-xanthine permease; Region: ncs2; TIGR00801
637905005236	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
637905005237	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
637905005238	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905005239	Walker A motif; other site
637905005240	ATP binding site [chemical binding]; other site
637905005241	Walker B motif; other site
637905005242	arginine finger; other site
637905005243	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
637905005244	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
637905005245	ArsC family; Region: ArsC; pfam03960
637905005246	catalytic residues [active]
637905005247	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
637905005248	Peptidase family M48; Region: Peptidase_M48; cl12018
637905005249	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905005250	binding surface
637905005251	TPR motif; other site
637905005252	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
637905005253	CPxP  motif; other site
637905005254	Domain of unknown function DUF20; Region: UPF0118; pfam01594
637905005255	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
637905005256	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
637905005257	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905005258	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
637905005259	putative dimerization interface [polypeptide binding]; other site
637905005260	Lysine efflux permease [General function prediction only]; Region: COG1279
637905005261	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
637905005262	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
637905005263	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
637905005264	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
637905005265	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
637905005266	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
637905005267	Transposase IS200 like; Region: Y1_Tnp; pfam01797
637905005268	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
637905005269	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
637905005270	catalytic triad [active]
637905005271	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
637905005272	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
637905005273	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
637905005274	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
637905005275	dihydrodipicolinate synthase; Region: dapA; TIGR00674
637905005276	dimer interface [polypeptide binding]; other site
637905005277	active site
637905005278	catalytic residue [active]
637905005279	lipoprotein; Provisional; Region: PRK11679
637905005280	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
637905005281	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
637905005282	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905005283	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
637905005284	Protein export membrane protein; Region: SecD_SecF; cl14618
637905005285	Pregnancy-associated plasma protein-A; Region: Peptidase_M43; cl17409
637905005286	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
637905005287	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
637905005288	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
637905005289	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
637905005290	FOG: PKD repeat [General function prediction only]; Region: COG3291
637905005291	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
637905005292	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
637905005293	Molybdopterin converting factor, small subunit [Coenzyme metabolism]; Region: MoaD; COG1977
637905005294	charged pocket; other site
637905005295	hydrophobic patch; other site
637905005296	hypothetical protein; Validated; Region: PRK07411
637905005297	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
637905005298	ATP binding site [chemical binding]; other site
637905005299	substrate interface [chemical binding]; other site
637905005300	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
637905005301	active site residue [active]
637905005302	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
637905005303	MPN+ (JAMM) motif; other site
637905005304	Zinc-binding site [ion binding]; other site
637905005305	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
637905005306	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
637905005307	dimer interface [polypeptide binding]; other site
637905005308	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905005309	catalytic residue [active]
637905005310	Protein of unknown function (DUF2897); Region: DUF2897; pfam11446
637905005311	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
637905005312	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
637905005313	Ligand binding site; other site
637905005314	oligomer interface; other site
637905005315	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
637905005316	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
637905005317	active site
637905005318	NAD binding site [chemical binding]; other site
637905005319	metal binding site [ion binding]; metal-binding site
637905005320	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
637905005321	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
637905005322	inhibitor-cofactor binding pocket; inhibition site
637905005323	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905005324	catalytic residue [active]
637905005325	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
637905005326	active site clefts [active]
637905005327	zinc binding site [ion binding]; other site
637905005328	dimer interface [polypeptide binding]; other site
637905005329	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
637905005330	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
637905005331	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
637905005332	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
637905005333	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
637905005334	metal binding site [ion binding]; metal-binding site
637905005335	dimer interface [polypeptide binding]; other site
637905005336	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
637905005337	ArsC family; Region: ArsC; pfam03960
637905005338	putative catalytic residues [active]
637905005339	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
637905005340	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
637905005341	PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439
637905005342	HPr interaction site; other site
637905005343	glycerol kinase (GK) interaction site [polypeptide binding]; other site
637905005344	active site
637905005345	phosphorylation site [posttranslational modification]
637905005346	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
637905005347	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
637905005348	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
637905005349	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
637905005350	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
637905005351	dimerization domain swap beta strand [polypeptide binding]; other site
637905005352	regulatory protein interface [polypeptide binding]; other site
637905005353	active site
637905005354	regulatory phosphorylation site [posttranslational modification]; other site
637905005355	Family description; Region: ACT_7; pfam13840
637905005356	Protein of unknown function (DUF3334); Region: DUF3334; pfam11813
637905005357	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
637905005358	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
637905005359	active site
637905005360	catalytic site [active]
637905005361	substrate binding site [chemical binding]; other site
637905005362	elongation factor G; Reviewed; Region: PRK00007
637905005363	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
637905005364	G1 box; other site
637905005365	putative GEF interaction site [polypeptide binding]; other site
637905005366	GTP/Mg2+ binding site [chemical binding]; other site
637905005367	Switch I region; other site
637905005368	G2 box; other site
637905005369	G3 box; other site
637905005370	Switch II region; other site
637905005371	G4 box; other site
637905005372	G5 box; other site
637905005373	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
637905005374	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
637905005375	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
637905005376	Uncharacterized conserved protein [Function unknown]; Region: COG2850
637905005377	Cupin-like domain; Region: Cupin_8; pfam13621
637905005378	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
637905005379	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
637905005380	Coenzyme A binding pocket [chemical binding]; other site
637905005381	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
637905005382	dimerization interface [polypeptide binding]; other site
637905005383	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
637905005384	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905005385	dimer interface [polypeptide binding]; other site
637905005386	putative CheW interface [polypeptide binding]; other site
637905005387	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
637905005388	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
637905005389	substrate binding pocket [chemical binding]; other site
637905005390	membrane-bound complex binding site; other site
637905005391	hinge residues; other site
637905005392	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
637905005393	NADH(P)-binding; Region: NAD_binding_10; pfam13460
637905005394	NAD(P) binding site [chemical binding]; other site
637905005395	putative active site [active]
637905005396	Uncharacterized conserved protein [Function unknown]; Region: COG1944
637905005397	YcaO-like family; Region: YcaO; pfam02624
637905005398	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
637905005399	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
637905005400	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
637905005401	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905005402	putative substrate translocation pore; other site
637905005403	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
637905005404	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
637905005405	ATP binding site [chemical binding]; other site
637905005406	Mg++ binding site [ion binding]; other site
637905005407	motif III; other site
637905005408	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905005409	nucleotide binding region [chemical binding]; other site
637905005410	ATP-binding site [chemical binding]; other site
637905005411	Calx-beta domain; Region: Calx-beta; cl02522
637905005412	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
637905005413	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
637905005414	YadA-like C-terminal region; Region: YadA; pfam03895
637905005415	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
637905005416	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905005417	N-terminal plug; other site
637905005418	ligand-binding site [chemical binding]; other site
637905005419	Phytochelatin synthase; Region: Phytochelatin; pfam05023
637905005420	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
637905005421	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
637905005422	YecR-like lipoprotein; Region: YecR; cl10256
637905005423	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
637905005424	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
637905005425	active site
637905005426	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
637905005427	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905005428	putative substrate translocation pore; other site
637905005429	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
637905005430	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905005431	S-adenosylmethionine binding site [chemical binding]; other site
637905005432	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
637905005433	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
637905005434	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
637905005435	dimer interface [polypeptide binding]; other site
637905005436	active site
637905005437	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
637905005438	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637905005439	ATP binding site [chemical binding]; other site
637905005440	putative Mg++ binding site [ion binding]; other site
637905005441	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905005442	nucleotide binding region [chemical binding]; other site
637905005443	ATP-binding site [chemical binding]; other site
637905005444	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
637905005445	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
637905005446	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
637905005447	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
637905005448	catalytic residues [active]
637905005449	Domain of unknown function (DUF4266); Region: DUF4266; pfam14086
637905005450	Protein of unknown function (DUF3570); Region: DUF3570; pfam12094
637905005451	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
637905005452	ApbE family; Region: ApbE; pfam02424
637905005453	Sulfatase; Region: Sulfatase; cl17466
637905005454	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
637905005455	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
637905005456	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
637905005457	Homeodomain-like domain; Region: HTH_23; pfam13384
637905005458	Winged helix-turn helix; Region: HTH_29; pfam13551
637905005459	Homeodomain-like domain; Region: HTH_32; pfam13565
637905005460	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
637905005461	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
637905005462	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905005463	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
637905005464	Walker A motif; other site
637905005465	ATP binding site [chemical binding]; other site
637905005466	Walker B motif; other site
637905005467	arginine finger; other site
637905005468	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
637905005469	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
637905005470	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
637905005471	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
637905005472	BON domain; Region: BON; pfam04972
637905005473	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
637905005474	TadE-like protein; Region: TadE; pfam07811
637905005475	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
637905005476	TadE-like protein; Region: TadE; pfam07811
637905005477	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
637905005478	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
637905005479	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
637905005480	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
637905005481	ATP binding site [chemical binding]; other site
637905005482	Walker A motif; other site
637905005483	hexamer interface [polypeptide binding]; other site
637905005484	Walker B motif; other site
637905005485	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
637905005486	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
637905005487	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
637905005488	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
637905005489	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905005490	TPR motif; other site
637905005491	TPR repeat; Region: TPR_11; pfam13414
637905005492	binding surface
637905005493	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905005494	binding surface
637905005495	TPR motif; other site
637905005496	TPR repeat; Region: TPR_11; pfam13414
637905005497	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905005498	binding surface
637905005499	TPR motif; other site
637905005500	TPR repeat; Region: TPR_11; pfam13414
637905005501	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
637905005502	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
637905005503	putative dimer interface [polypeptide binding]; other site
637905005504	putative anticodon binding site; other site
637905005505	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
637905005506	homodimer interface [polypeptide binding]; other site
637905005507	motif 1; other site
637905005508	motif 2; other site
637905005509	active site
637905005510	motif 3; other site
637905005511	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
637905005512	putative active site [active]
637905005513	putative CoA binding site [chemical binding]; other site
637905005514	nudix motif; other site
637905005515	metal binding site [ion binding]; metal-binding site
637905005516	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
637905005517	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
637905005518	chorismate binding enzyme; Region: Chorismate_bind; cl10555
637905005519	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
637905005520	Fumarase C-terminus; Region: Fumerase_C; pfam05683
637905005521	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
637905005522	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
637905005523	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
637905005524	Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925
637905005525	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
637905005526	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
637905005527	tetramer interface [polypeptide binding]; other site
637905005528	active site
637905005529	Mg2+/Mn2+ binding site [ion binding]; other site
637905005530	isocitrate lyase; Region: PLN02892
637905005531	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905005532	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905005533	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
637905005534	substrate binding pocket [chemical binding]; other site
637905005535	dimerization interface [polypeptide binding]; other site
637905005536	malate synthase G; Provisional; Region: PRK02999
637905005537	active site
637905005538	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
637905005539	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
637905005540	putative catalytic cysteine [active]
637905005541	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
637905005542	putative active site [active]
637905005543	metal binding site [ion binding]; metal-binding site
637905005544	hypothetical protein; Provisional; Region: PRK11111
637905005545	MarC family integral membrane protein; Region: MarC; cl00919
637905005546	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
637905005547	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
637905005548	Zn2+ binding site [ion binding]; other site
637905005549	Mg2+ binding site [ion binding]; other site
637905005550	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
637905005551	5'-nucleotidase; Provisional; Region: PRK03826
637905005552	aminotransferase AlaT; Validated; Region: PRK09265
637905005553	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
637905005554	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905005555	homodimer interface [polypeptide binding]; other site
637905005556	catalytic residue [active]
637905005557	elongation factor P; Validated; Region: PRK00529
637905005558	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
637905005559	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
637905005560	RNA binding site [nucleotide binding]; other site
637905005561	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
637905005562	RNA binding site [nucleotide binding]; other site
637905005563	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
637905005564	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; cl01823
637905005565	flavodoxin FldA; Validated; Region: PRK09267
637905005566	LexA regulated protein; Provisional; Region: PRK11675
637905005567	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
637905005568	acyl-CoA esterase; Provisional; Region: PRK10673
637905005569	PGAP1-like protein; Region: PGAP1; pfam07819
637905005570	replication initiation regulator SeqA; Provisional; Region: PRK11187
637905005571	phosphoglucomutase; Validated; Region: PRK07564
637905005572	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
637905005573	active site
637905005574	substrate binding site [chemical binding]; other site
637905005575	metal binding site [ion binding]; metal-binding site
637905005576	methionine sulfoxide reductase A; Provisional; Region: PRK14054
637905005577	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
637905005578	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
637905005579	putative active site [active]
637905005580	Zn binding site [ion binding]; other site
637905005581	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
637905005582	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
637905005583	tetramer interface [polypeptide binding]; other site
637905005584	TPP-binding site [chemical binding]; other site
637905005585	heterodimer interface [polypeptide binding]; other site
637905005586	phosphorylation loop region [posttranslational modification]
637905005587	3-methyl-2-oxobutanate dehydrogenase; Provisional; Region: PTZ00182
637905005588	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
637905005589	alpha subunit interface [polypeptide binding]; other site
637905005590	TPP binding site [chemical binding]; other site
637905005591	heterodimer interface [polypeptide binding]; other site
637905005592	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
637905005593	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
637905005594	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
637905005595	E3 interaction surface; other site
637905005596	lipoyl attachment site [posttranslational modification]; other site
637905005597	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
637905005598	E3 interaction surface; other site
637905005599	lipoyl attachment site [posttranslational modification]; other site
637905005600	e3 binding domain; Region: E3_binding; pfam02817
637905005601	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
637905005602	quinolinate synthetase; Provisional; Region: PRK09375
637905005603	Nitrate and nitrite sensing; Region: NIT; pfam08376
637905005604	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
637905005605	HAMP domain; Region: HAMP; pfam00672
637905005606	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905005607	dimer interface [polypeptide binding]; other site
637905005608	putative CheW interface [polypeptide binding]; other site
637905005609	RecX family; Region: RecX; pfam02631
637905005610	RecX family; Region: RecX; pfam02631
637905005611	Flagellin N-methylase; Region: FliB; pfam03692
637905005612	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
637905005613	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
637905005614	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
637905005615	putative active site [active]
637905005616	catalytic site [active]
637905005617	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
637905005618	putative active site [active]
637905005619	catalytic site [active]
637905005620	hypothetical protein; Provisional; Region: PRK05421
637905005621	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
637905005622	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
637905005623	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637905005624	ATP binding site [chemical binding]; other site
637905005625	putative Mg++ binding site [ion binding]; other site
637905005626	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905005627	nucleotide binding region [chemical binding]; other site
637905005628	ATP-binding site [chemical binding]; other site
637905005629	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
637905005630	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
637905005631	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637905005632	DNA binding site [nucleotide binding]
637905005633	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
637905005634	Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234
637905005635	putative active site [active]
637905005636	Zn binding site [ion binding]; other site
637905005637	Protein of unknown function (DUF1315); Region: DUF1315; cl01215
637905005638	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
637905005639	active site
637905005640	homodimer interface [polypeptide binding]; other site
637905005641	protease 4; Provisional; Region: PRK10949
637905005642	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
637905005643	tandem repeat interface [polypeptide binding]; other site
637905005644	oligomer interface [polypeptide binding]; other site
637905005645	active site residues [active]
637905005646	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
637905005647	tandem repeat interface [polypeptide binding]; other site
637905005648	oligomer interface [polypeptide binding]; other site
637905005649	active site residues [active]
637905005650	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
637905005651	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
637905005652	active site
637905005653	FMN binding site [chemical binding]; other site
637905005654	2,4-decadienoyl-CoA binding site; other site
637905005655	catalytic residue [active]
637905005656	4Fe-4S cluster binding site [ion binding]; other site
637905005657	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
637905005658	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
637905005659	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
637905005660	catalytic loop [active]
637905005661	iron binding site [ion binding]; other site
637905005662	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
637905005663	dimer interface [polypeptide binding]; other site
637905005664	putative radical transfer pathway; other site
637905005665	diiron center [ion binding]; other site
637905005666	tyrosyl radical; other site
637905005667	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
637905005668	ATP cone domain; Region: ATP-cone; pfam03477
637905005669	Class I ribonucleotide reductase; Region: RNR_I; cd01679
637905005670	active site
637905005671	dimer interface [polypeptide binding]; other site
637905005672	catalytic residues [active]
637905005673	effector binding site; other site
637905005674	R2 peptide binding site; other site
637905005675	phosphoglycolate phosphatase; Provisional; Region: PRK13222
637905005676	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
637905005677	motif II; other site
637905005678	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
637905005679	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905005680	S-adenosylmethionine binding site [chemical binding]; other site
637905005681	DNA gyrase subunit A; Validated; Region: PRK05560
637905005682	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
637905005683	CAP-like domain; other site
637905005684	active site
637905005685	primary dimer interface [polypeptide binding]; other site
637905005686	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
637905005687	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
637905005688	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
637905005689	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
637905005690	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
637905005691	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
637905005692	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
637905005693	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
637905005694	catalytic residue [active]
637905005695	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
637905005696	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
637905005697	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905005698	homodimer interface [polypeptide binding]; other site
637905005699	catalytic residue [active]
637905005700	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
637905005701	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
637905005702	hinge; other site
637905005703	active site
637905005704	cytidylate kinase; Provisional; Region: cmk; PRK00023
637905005705	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
637905005706	CMP-binding site; other site
637905005707	The sites determining sugar specificity; other site
637905005708	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
637905005709	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
637905005710	RNA binding site [nucleotide binding]; other site
637905005711	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
637905005712	RNA binding site [nucleotide binding]; other site
637905005713	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
637905005714	RNA binding site [nucleotide binding]; other site
637905005715	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
637905005716	RNA binding site [nucleotide binding]; other site
637905005717	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
637905005718	RNA binding site [nucleotide binding]; other site
637905005719	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
637905005720	RNA binding site [nucleotide binding]; other site
637905005721	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
637905005722	IHF dimer interface [polypeptide binding]; other site
637905005723	IHF - DNA interface [nucleotide binding]; other site
637905005724	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
637905005725	tetratricopeptide repeat protein; Provisional; Region: PRK11788
637905005726	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
637905005727	active site
637905005728	dimer interface [polypeptide binding]; other site
637905005729	short chain dehydrogenase; Provisional; Region: PRK07576
637905005730	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
637905005731	NAD(P) binding site [chemical binding]; other site
637905005732	substrate binding site [chemical binding]; other site
637905005733	homotetramer interface [polypeptide binding]; other site
637905005734	active site
637905005735	homodimer interface [polypeptide binding]; other site
637905005736	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
637905005737	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
637905005738	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
637905005739	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
637905005740	active site
637905005741	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
637905005742	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
637905005743	Domain of unknown function (DUF1904); Region: DUF1904; pfam08921
637905005744	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
637905005745	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
637905005746	domain interface [polypeptide binding]; other site
637905005747	putative active site [active]
637905005748	catalytic site [active]
637905005749	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
637905005750	domain interface [polypeptide binding]; other site
637905005751	putative active site [active]
637905005752	catalytic site [active]
637905005753	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
637905005754	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905005755	putative substrate translocation pore; other site
637905005756	Uncharacterized conserved protein [Function unknown]; Region: COG3148
637905005757	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
637905005758	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905005759	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
637905005760	substrate binding pocket [chemical binding]; other site
637905005761	dimerization interface [polypeptide binding]; other site
637905005762	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905005763	Major Facilitator Superfamily; Region: MFS_1; pfam07690
637905005764	putative substrate translocation pore; other site
637905005765	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
637905005766	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
637905005767	MarR family; Region: MarR_2; pfam12802
637905005768	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
637905005769	GIY-YIG motif/motif A; other site
637905005770	putative active site [active]
637905005771	putative metal binding site [ion binding]; other site
637905005772	DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238
637905005773	DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236
637905005774	DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237
637905005775	AAA-like domain; Region: AAA_10; pfam12846
637905005776	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
637905005777	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
637905005778	active site
637905005779	Protein of unknown function DUF262; Region: DUF262; pfam03235
637905005780	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637905005781	AAA domain; Region: AAA_21; pfam13304
637905005782	Walker A/P-loop; other site
637905005783	ATP binding site [chemical binding]; other site
637905005784	Q-loop/lid; other site
637905005785	Domain of unknown function (DUF1832); Region: DUF1832; pfam08870
637905005786	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
637905005787	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637905005788	Walker A/P-loop; other site
637905005789	ATP binding site [chemical binding]; other site
637905005790	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637905005791	ABC transporter signature motif; other site
637905005792	Walker B; other site
637905005793	D-loop; other site
637905005794	H-loop/switch region; other site
637905005795	hypothetical protein; Provisional; Region: PRK06850
637905005796	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
637905005797	Active Sites [active]
637905005798	DNA-sulfur modification-associated; Region: DndB; pfam14072
637905005799	DGQHR domain; Region: DGQHR; TIGR03187
637905005800	DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096
637905005801	Peptidase M15; Region: Peptidase_M15_3; cl01194
637905005802	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
637905005803	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
637905005804	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
637905005805	metal ion-dependent adhesion site (MIDAS); other site
637905005806	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
637905005807	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
637905005808	DNA binding residues [nucleotide binding]
637905005809	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
637905005810	Mechanosensitive ion channel; Region: MS_channel; pfam00924
637905005811	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
637905005812	Part of AAA domain; Region: AAA_19; pfam13245
637905005813	Family description; Region: UvrD_C_2; pfam13538
637905005814	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
637905005815	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
637905005816	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
637905005817	active site
637905005818	Zn binding site [ion binding]; other site
637905005819	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
637905005820	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
637905005821	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
637905005822	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
637905005823	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
637905005824	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
637905005825	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
637905005826	GDP-binding site [chemical binding]; other site
637905005827	ACT binding site; other site
637905005828	IMP binding site; other site
637905005829	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905005830	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905005831	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
637905005832	dimerization interface [polypeptide binding]; other site
637905005833	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
637905005834	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637905005835	Walker A/P-loop; other site
637905005836	ATP binding site [chemical binding]; other site
637905005837	Q-loop/lid; other site
637905005838	ABC transporter signature motif; other site
637905005839	Walker B; other site
637905005840	D-loop; other site
637905005841	H-loop/switch region; other site
637905005842	ABC transporter; Region: ABC_tran_2; pfam12848
637905005843	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
637905005844	AMP-binding domain protein; Validated; Region: PRK08315
637905005845	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
637905005846	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
637905005847	acyl-activating enzyme (AAE) consensus motif; other site
637905005848	putative AMP binding site [chemical binding]; other site
637905005849	putative active site [active]
637905005850	putative CoA binding site [chemical binding]; other site
637905005851	PAS domain; Region: PAS_9; pfam13426
637905005852	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
637905005853	putative active site [active]
637905005854	heme pocket [chemical binding]; other site
637905005855	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905005856	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905005857	metal binding site [ion binding]; metal-binding site
637905005858	active site
637905005859	I-site; other site
637905005860	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
637905005861	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
637905005862	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
637905005863	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
637905005864	active site
637905005865	catalytic triad [active]
637905005866	calcium binding site 1 [ion binding]; other site
637905005867	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
637905005868	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
637905005869	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
637905005870	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
637905005871	active site
637905005872	Peptidase family M1; Region: Peptidase_M1; pfam01433
637905005873	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
637905005874	Zn binding site [ion binding]; other site
637905005875	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
637905005876	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
637905005877	active site
637905005878	DNA binding site [nucleotide binding]
637905005879	Int/Topo IB signature motif; other site
637905005880	Ecdysteroid kinase; Region: EcKinase; cl17738
637905005881	Cache domain; Region: Cache_1; pfam02743
637905005882	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905005883	dimerization interface [polypeptide binding]; other site
637905005884	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
637905005885	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905005886	dimer interface [polypeptide binding]; other site
637905005887	putative CheW interface [polypeptide binding]; other site
637905005888	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
637905005889	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
637905005890	NADP binding site [chemical binding]; other site
637905005891	homodimer interface [polypeptide binding]; other site
637905005892	active site
637905005893	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
637905005894	Coenzyme A binding pocket [chemical binding]; other site
637905005895	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
637905005896	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
637905005897	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
637905005898	heme binding site [chemical binding]; other site
637905005899	ferroxidase pore; other site
637905005900	ferroxidase diiron center [ion binding]; other site
637905005901	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
637905005902	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
637905005903	heme binding site [chemical binding]; other site
637905005904	ferroxidase pore; other site
637905005905	ferroxidase diiron center [ion binding]; other site
637905005906	putative RNA methyltransferase; Provisional; Region: PRK10433
637905005907	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
637905005908	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
637905005909	active site
637905005910	catalytic site [active]
637905005911	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
637905005912	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
637905005913	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
637905005914	Protein of unknown function (DUF2989); Region: DUF2989; pfam11207
637905005915	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
637905005916	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
637905005917	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
637905005918	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
637905005919	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
637905005920	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905005921	homodimer interface [polypeptide binding]; other site
637905005922	catalytic residue [active]
637905005923	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
637905005924	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
637905005925	phosphate binding site [ion binding]; other site
637905005926	putative substrate binding pocket [chemical binding]; other site
637905005927	dimer interface [polypeptide binding]; other site
637905005928	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
637905005929	Protein of unknown function (DUF2987); Region: DUF2987; pfam11205
637905005930	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
637905005931	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
637905005932	Ligand Binding Site [chemical binding]; other site
637905005933	universal stress protein UspE; Provisional; Region: PRK11175
637905005934	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
637905005935	Ligand Binding Site [chemical binding]; other site
637905005936	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
637905005937	Ligand Binding Site [chemical binding]; other site
637905005938	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
637905005939	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
637905005940	ligand binding site [chemical binding]; other site
637905005941	flexible hinge region; other site
637905005942	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
637905005943	putative switch regulator; other site
637905005944	non-specific DNA interactions [nucleotide binding]; other site
637905005945	DNA binding site [nucleotide binding]
637905005946	sequence specific DNA binding site [nucleotide binding]; other site
637905005947	putative cAMP binding site [chemical binding]; other site
637905005948	Family description; Region: DsbD_2; pfam13386
637905005949	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
637905005950	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
637905005951	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
637905005952	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
637905005953	metal-binding site [ion binding]
637905005954	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
637905005955	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
637905005956	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
637905005957	FixH; Region: FixH; pfam05751
637905005958	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
637905005959	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
637905005960	Cytochrome c; Region: Cytochrom_C; pfam00034
637905005961	Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545
637905005962	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
637905005963	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
637905005964	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
637905005965	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
637905005966	Low-spin heme binding site [chemical binding]; other site
637905005967	Putative water exit pathway; other site
637905005968	Binuclear center (active site) [active]
637905005969	Putative proton exit pathway; other site
637905005970	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
637905005971	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
637905005972	active site
637905005973	phosphorylation site [posttranslational modification]
637905005974	intermolecular recognition site; other site
637905005975	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
637905005976	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
637905005977	Zn2+ binding site [ion binding]; other site
637905005978	Mg2+ binding site [ion binding]; other site
637905005979	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
637905005980	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
637905005981	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
637905005982	Int/Topo IB signature motif; other site
637905005983	virion protein; Provisional; Region: V; PHA02564
637905005984	Domain of unknown function DUF87; Region: DUF87; pfam01935
637905005985	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
637905005986	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
637905005987	G1 box; other site
637905005988	GTP/Mg2+ binding site [chemical binding]; other site
637905005989	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
637905005990	hypothetical protein; Provisional; Region: PRK06847
637905005991	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
637905005992	GAF domain; Region: GAF; pfam01590
637905005993	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905005994	Walker A motif; other site
637905005995	ATP binding site [chemical binding]; other site
637905005996	Walker B motif; other site
637905005997	arginine finger; other site
637905005998	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
637905005999	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
637905006000	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
637905006001	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
637905006002	iron binding site [ion binding]; other site
637905006003	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
637905006004	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
637905006005	Domain of unknown function (DUF1971); Region: DUF1971; cl17717
637905006006	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
637905006007	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
637905006008	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905006009	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
637905006010	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905006011	N-terminal plug; other site
637905006012	ligand-binding site [chemical binding]; other site
637905006013	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
637905006014	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
637905006015	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
637905006016	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
637905006017	RES domain; Region: RES; cl02411
637905006018	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
637905006019	Aspartase; Region: Aspartase; cd01357
637905006020	active sites [active]
637905006021	tetramer interface [polypeptide binding]; other site
637905006022	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
637905006023	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
637905006024	inhibitor site; inhibition site
637905006025	active site
637905006026	dimer interface [polypeptide binding]; other site
637905006027	catalytic residue [active]
637905006028	Cupin domain; Region: Cupin_2; pfam07883
637905006029	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
637905006030	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905006031	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
637905006032	dimerization interface [polypeptide binding]; other site
637905006033	PAS domain S-box; Region: sensory_box; TIGR00229
637905006034	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
637905006035	putative active site [active]
637905006036	heme pocket [chemical binding]; other site
637905006037	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905006038	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905006039	metal binding site [ion binding]; metal-binding site
637905006040	active site
637905006041	I-site; other site
637905006042	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
637905006043	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
637905006044	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
637905006045	lipoyl-biotinyl attachment site [posttranslational modification]; other site
637905006046	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
637905006047	AAA domain; Region: AAA_32; pfam13654
637905006048	lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764
637905006049	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
637905006050	potential frameshift: common BLAST hit: gi|170726810|ref|YP_001760836.1|  manganese-dependent inorganic pyrophosphatase
637905006051	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
637905006052	DHHA2 domain; Region: DHHA2; pfam02833
637905006053	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
637905006054	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
637905006055	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
637905006056	substrate binding pocket [chemical binding]; other site
637905006057	membrane-bound complex binding site; other site
637905006058	hinge residues; other site
637905006059	secretion system apparatus protein SsaU; Reviewed; Region: PRK12721
637905006060	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
637905006061	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
637905006062	Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794
637905006063	type III secretion system protein YscR; Provisional; Region: PRK12797
637905006064	type III secretion system protein SsaQ; Validated; Region: PRK08035
637905006065	type III secretion system ATPase; Validated; Region: PRK06820
637905006066	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
637905006067	Walker A motif/ATP binding site; other site
637905006068	Walker B motif; other site
637905006069	secretion system apparatus protein SsaV; Provisional; Region: PRK12720
637905006070	FHIPEP family; Region: FHIPEP; pfam00771
637905006071	type III secretion system protein SsaM; Provisional; Region: PRK15353
637905006072	HrpJ-like domain; Region: HrpJ; cl15454
637905006073	type III secretion effector delivery regulator, TyeA family; Region: type_III_tyeA; TIGR02511
637905006074	type III secretion system protein SsaK; Provisional; Region: PRK15354
637905006075	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
637905006076	Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327
637905006077	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
637905006078	Type III secretion needle MxiH like; Region: MxiH; cl09641
637905006079	Protein of unknown function (DUF1039); Region: DUF1039; pfam06287
637905006080	Type III secretion needle MxiH like; Region: MxiH; cl09641
637905006081	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
637905006082	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
637905006083	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
637905006084	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
637905006085	pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360
637905006086	pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361
637905006087	pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362
637905006088	pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363
637905006089	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905006090	binding surface
637905006091	TPR motif; other site
637905006092	EspA-like secreted protein; Region: EspA; cl04069
637905006093	EspA-like secreted protein; Region: EspA; pfam03433
637905006094	type III secretion system protein SsaD; Provisional; Region: PRK15367
637905006095	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
637905006096	outer membrane secretin SsaC; Provisional; Region: PRK15346
637905006097	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
637905006098	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
637905006099	two component system sensor kinase SsrA; Provisional; Region: PRK15347
637905006100	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
637905006101	dimerization interface [polypeptide binding]; other site
637905006102	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
637905006103	dimer interface [polypeptide binding]; other site
637905006104	phosphorylation site [posttranslational modification]
637905006105	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905006106	ATP binding site [chemical binding]; other site
637905006107	Mg2+ binding site [ion binding]; other site
637905006108	G-X-G motif; other site
637905006109	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905006110	active site
637905006111	phosphorylation site [posttranslational modification]
637905006112	intermolecular recognition site; other site
637905006113	dimerization interface [polypeptide binding]; other site
637905006114	Hpt domain; Region: Hpt; pfam01627
637905006115	putative binding surface; other site
637905006116	active site
637905006117	two component system sensor kinase SsrB; Provisional; Region: PRK15369
637905006118	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905006119	active site
637905006120	phosphorylation site [posttranslational modification]
637905006121	intermolecular recognition site; other site
637905006122	dimerization interface [polypeptide binding]; other site
637905006123	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
637905006124	DNA binding residues [nucleotide binding]
637905006125	dimerization interface [polypeptide binding]; other site
637905006126	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
637905006127	Catalytic site [active]
637905006128	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
637905006129	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
637905006130	active site
637905006131	DNA binding site [nucleotide binding]
637905006132	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
637905006133	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
637905006134	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
637905006135	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637905006136	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905006137	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
637905006138	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
637905006139	META domain; Region: META; pfam03724
637905006140	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
637905006141	DNA binding site [nucleotide binding]
637905006142	Uncharacterized conserved protein [Function unknown]; Region: COG1262
637905006143	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
637905006144	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
637905006145	Interdomain contacts; other site
637905006146	Cytokine receptor motif; other site
637905006147	Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080
637905006148	Ca binding site [ion binding]; other site
637905006149	ligand binding site I [chemical binding]; other site
637905006150	homodimer interface [polypeptide binding]; other site
637905006151	ligand binding site II [chemical binding]; other site
637905006152	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
637905006153	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637905006154	DNA binding site [nucleotide binding]
637905006155	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
637905006156	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
637905006157	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
637905006158	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905006159	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
637905006160	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905006161	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
637905006162	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905006163	ATP binding site [chemical binding]; other site
637905006164	Mg2+ binding site [ion binding]; other site
637905006165	G-X-G motif; other site
637905006166	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
637905006167	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905006168	active site
637905006169	phosphorylation site [posttranslational modification]
637905006170	intermolecular recognition site; other site
637905006171	dimerization interface [polypeptide binding]; other site
637905006172	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905006173	Walker A motif; other site
637905006174	ATP binding site [chemical binding]; other site
637905006175	Walker B motif; other site
637905006176	arginine finger; other site
637905006177	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
637905006178	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
637905006179	FtsX-like permease family; Region: FtsX; pfam02687
637905006180	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
637905006181	FtsX-like permease family; Region: FtsX; pfam02687
637905006182	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
637905006183	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
637905006184	Walker A/P-loop; other site
637905006185	ATP binding site [chemical binding]; other site
637905006186	Q-loop/lid; other site
637905006187	ABC transporter signature motif; other site
637905006188	Walker B; other site
637905006189	D-loop; other site
637905006190	H-loop/switch region; other site
637905006191	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
637905006192	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637905006193	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905006194	putative transporter; Provisional; Region: PRK11043
637905006195	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905006196	putative substrate translocation pore; other site
637905006197	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
637905006198	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905006199	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
637905006200	dimerization interface [polypeptide binding]; other site
637905006201	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
637905006202	YccA-like proteins; Region: YccA_like; cd10433
637905006203	sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012
637905006204	sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010
637905006205	DsrH like protein; Region: DsrH; cl17347
637905006206	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
637905006207	DsrC like protein; Region: DsrC; pfam04358
637905006208	seryl-tRNA synthetase; Provisional; Region: PRK05431
637905006209	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
637905006210	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
637905006211	dimer interface [polypeptide binding]; other site
637905006212	active site
637905006213	motif 1; other site
637905006214	motif 2; other site
637905006215	motif 3; other site
637905006216	camphor resistance protein CrcB; Provisional; Region: PRK14197
637905006217	recombination factor protein RarA; Reviewed; Region: PRK13342
637905006218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905006219	Walker A motif; other site
637905006220	ATP binding site [chemical binding]; other site
637905006221	Walker B motif; other site
637905006222	arginine finger; other site
637905006223	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
637905006224	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
637905006225	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
637905006226	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
637905006227	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
637905006228	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
637905006229	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
637905006230	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
637905006231	putative DNA binding site [nucleotide binding]; other site
637905006232	putative Zn2+ binding site [ion binding]; other site
637905006233	AsnC family; Region: AsnC_trans_reg; pfam01037
637905006234	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
637905006235	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
637905006236	hexamer interface [polypeptide binding]; other site
637905006237	ligand binding site [chemical binding]; other site
637905006238	putative active site [active]
637905006239	NAD(P) binding site [chemical binding]; other site
637905006240	thioredoxin reductase; Provisional; Region: PRK10262
637905006241	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
637905006242	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
637905006243	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
637905006244	23S rRNA binding site [nucleotide binding]; other site
637905006245	L21 binding site [polypeptide binding]; other site
637905006246	L13 binding site [polypeptide binding]; other site
637905006247	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
637905006248	translation initiation factor IF-3; Region: infC; TIGR00168
637905006249	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
637905006250	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
637905006251	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
637905006252	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
637905006253	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
637905006254	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
637905006255	active site
637905006256	dimer interface [polypeptide binding]; other site
637905006257	motif 1; other site
637905006258	motif 2; other site
637905006259	motif 3; other site
637905006260	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
637905006261	anticodon binding site; other site
637905006262	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
637905006263	pteridine reductase; Provisional; Region: PRK09135
637905006264	NAD(P) binding site [chemical binding]; other site
637905006265	active site
637905006266	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
637905006267	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
637905006268	Lumazine binding domain; Region: Lum_binding; pfam00677
637905006269	Lumazine binding domain; Region: Lum_binding; pfam00677
637905006270	multidrug efflux protein; Reviewed; Region: PRK01766
637905006271	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
637905006272	cation binding site [ion binding]; other site
637905006273	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
637905006274	CoA binding domain; Region: CoA_binding_2; pfam13380
637905006275	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
637905006276	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
637905006277	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
637905006278	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637905006279	Coenzyme A binding pocket [chemical binding]; other site
637905006280	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905006281	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905006282	metal binding site [ion binding]; metal-binding site
637905006283	active site
637905006284	I-site; other site
637905006285	putative metal dependent hydrolase; Provisional; Region: PRK11598
637905006286	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
637905006287	Sulfatase; Region: Sulfatase; pfam00884
637905006288	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
637905006289	MarR family; Region: MarR; pfam01047
637905006290	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
637905006291	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
637905006292	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
637905006293	active site
637905006294	intersubunit interface [polypeptide binding]; other site
637905006295	catalytic residue [active]
637905006296	phosphogluconate dehydratase; Validated; Region: PRK09054
637905006297	6-phosphogluconate dehydratase; Region: edd; TIGR01196
637905006298	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
637905006299	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
637905006300	putative active site [active]
637905006301	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
637905006302	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
637905006303	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
637905006304	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
637905006305	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
637905006306	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
637905006307	putative active site [active]
637905006308	pyruvate kinase; Provisional; Region: PRK05826
637905006309	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
637905006310	domain interfaces; other site
637905006311	active site
637905006312	acyl-CoA dehydrogenase; Reviewed; Region: PRK13026
637905006313	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
637905006314	active site
637905006315	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
637905006316	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
637905006317	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
637905006318	Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461
637905006319	active site
637905006320	Zn binding site [ion binding]; other site
637905006321	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
637905006322	SEC-C motif; Region: SEC-C; pfam02810
637905006323	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
637905006324	GAF domain; Region: GAF; pfam01590
637905006325	PAS domain; Region: PAS_9; pfam13426
637905006326	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905006327	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905006328	metal binding site [ion binding]; metal-binding site
637905006329	active site
637905006330	I-site; other site
637905006331	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
637905006332	Protein of unknown function (DUF406); Region: DUF406; pfam04175
637905006333	Ribosomal S4P (gammaproteobacterial); Region: Ribosomal_S4Pg; pfam11993
637905006334	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
637905006335	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
637905006336	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
637905006337	catalytic residue [active]
637905006338	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
637905006339	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
637905006340	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
637905006341	Ligand Binding Site [chemical binding]; other site
637905006342	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
637905006343	excinuclease ABC subunit B; Provisional; Region: PRK05298
637905006344	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637905006345	ATP binding site [chemical binding]; other site
637905006346	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905006347	nucleotide binding region [chemical binding]; other site
637905006348	ATP-binding site [chemical binding]; other site
637905006349	Ultra-violet resistance protein B; Region: UvrB; pfam12344
637905006350	UvrB/uvrC motif; Region: UVR; pfam02151
637905006351	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905006352	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905006353	metal binding site [ion binding]; metal-binding site
637905006354	active site
637905006355	I-site; other site
637905006356	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
637905006357	electron transport complex protein RsxA; Provisional; Region: PRK05151
637905006358	electron transport complex protein RnfB; Provisional; Region: PRK05113
637905006359	Putative Fe-S cluster; Region: FeS; pfam04060
637905006360	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
637905006361	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
637905006362	SLBB domain; Region: SLBB; pfam10531
637905006363	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
637905006364	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
637905006365	electron transport complex protein RnfG; Validated; Region: PRK01908
637905006366	electron transport complex RsxE subunit; Provisional; Region: PRK12405
637905006367	endonuclease III; Provisional; Region: PRK10702
637905006368	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
637905006369	minor groove reading motif; other site
637905006370	helix-hairpin-helix signature motif; other site
637905006371	substrate binding pocket [chemical binding]; other site
637905006372	active site
637905006373	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
637905006374	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
637905006375	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
637905006376	dimer interface [polypeptide binding]; other site
637905006377	active site
637905006378	metal binding site [ion binding]; metal-binding site
637905006379	glutathione binding site [chemical binding]; other site
637905006380	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
637905006381	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905006382	N-terminal plug; other site
637905006383	ligand-binding site [chemical binding]; other site
637905006384	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
637905006385	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
637905006386	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905006387	Walker A motif; other site
637905006388	ATP binding site [chemical binding]; other site
637905006389	Walker B motif; other site
637905006390	arginine finger; other site
637905006391	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
637905006392	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
637905006393	RuvA N terminal domain; Region: RuvA_N; pfam01330
637905006394	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
637905006395	active site
637905006396	putative DNA-binding cleft [nucleotide binding]; other site
637905006397	dimer interface [polypeptide binding]; other site
637905006398	hypothetical protein; Validated; Region: PRK00110
637905006399	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
637905006400	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
637905006401	dimer interface [polypeptide binding]; other site
637905006402	anticodon binding site; other site
637905006403	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
637905006404	homodimer interface [polypeptide binding]; other site
637905006405	motif 1; other site
637905006406	active site
637905006407	motif 2; other site
637905006408	GAD domain; Region: GAD; pfam02938
637905006409	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
637905006410	active site
637905006411	motif 3; other site
637905006412	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905006413	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905006414	metal binding site [ion binding]; metal-binding site
637905006415	active site
637905006416	I-site; other site
637905006417	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905006418	S-adenosylmethionine binding site [chemical binding]; other site
637905006419	Methyltransferase domain; Region: Methyltransf_23; pfam13489
637905006420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905006421	S-adenosylmethionine binding site [chemical binding]; other site
637905006422	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
637905006423	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
637905006424	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
637905006425	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
637905006426	Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397
637905006427	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
637905006428	Domain of unknown function (DUF3541); Region: DUF3541; pfam12060
637905006429	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905006430	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905006431	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
637905006432	dimerization interface [polypeptide binding]; other site
637905006433	SprA-related family; Region: SprA-related; pfam12118
637905006434	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
637905006435	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637905006436	FeS/SAM binding site; other site
637905006437	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
637905006438	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
637905006439	ThiS interaction site; other site
637905006440	putative active site [active]
637905006441	tetramer interface [polypeptide binding]; other site
637905006442	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
637905006443	thiS-thiF/thiG interaction site; other site
637905006444	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
637905006445	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
637905006446	ATP binding site [chemical binding]; other site
637905006447	substrate interface [chemical binding]; other site
637905006448	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
637905006449	dimer interface [polypeptide binding]; other site
637905006450	HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898
637905006451	substrate binding site [chemical binding]; other site
637905006452	ATP binding site [chemical binding]; other site
637905006453	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
637905006454	active site
637905006455	thiamine phosphate binding site [chemical binding]; other site
637905006456	pyrophosphate binding site [ion binding]; other site
637905006457	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
637905006458	ThiC-associated domain; Region: ThiC-associated; pfam13667
637905006459	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
637905006460	Haemolysin-III related; Region: HlyIII; cl03831
637905006461	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
637905006462	DTW domain; Region: DTW; cl01221
637905006463	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
637905006464	active site
637905006465	catalytic residues [active]
637905006466	metal binding site [ion binding]; metal-binding site
637905006467	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905006468	putative substrate translocation pore; other site
637905006469	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905006470	Major Facilitator Superfamily; Region: MFS_1; pfam07690
637905006471	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
637905006472	DNA binding site [nucleotide binding]
637905006473	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
637905006474	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
637905006475	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
637905006476	putative active site [active]
637905006477	putative dimer interface [polypeptide binding]; other site
637905006478	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
637905006479	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
637905006480	active site
637905006481	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
637905006482	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
637905006483	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
637905006484	TrkA-N domain; Region: TrkA_N; pfam02254
637905006485	TIGR03503 family protein; Region: TIGR03503
637905006486	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
637905006487	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
637905006488	active site
637905006489	catalytic site [active]
637905006490	substrate binding site [chemical binding]; other site
637905006491	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
637905006492	RNA/DNA hybrid binding site [nucleotide binding]; other site
637905006493	active site
637905006494	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
637905006495	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905006496	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
637905006497	putative dimerization interface [polypeptide binding]; other site
637905006498	Methyltransferase domain; Region: Methyltransf_23; pfam13489
637905006499	Methyltransferase domain; Region: Methyltransf_11; pfam08241
637905006500	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
637905006501	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
637905006502	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
637905006503	N-acetyl-D-glucosamine binding site [chemical binding]; other site
637905006504	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
637905006505	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
637905006506	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
637905006507	Intracellular proteinase inhibitor; Region: BsuPI; pfam12690
637905006508	AsmA family; Region: AsmA; pfam05170
637905006509	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
637905006510	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
637905006511	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
637905006512	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905006513	dimerization interface [polypeptide binding]; other site
637905006514	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
637905006515	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905006516	dimer interface [polypeptide binding]; other site
637905006517	putative CheW interface [polypeptide binding]; other site
637905006518	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
637905006519	TMAO/DMSO reductase; Reviewed; Region: PRK05363
637905006520	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
637905006521	Moco binding site; other site
637905006522	metal coordination site [ion binding]; other site
637905006523	TMAO/DMSO reductase; Reviewed; Region: PRK05363
637905006524	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
637905006525	RmuC family; Region: RmuC; pfam02646
637905006526	lytic murein transglycosylase; Provisional; Region: PRK11619
637905006527	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
637905006528	N-acetyl-D-glucosamine binding site [chemical binding]; other site
637905006529	catalytic residue [active]
637905006530	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
637905006531	MoxR-like ATPases [General function prediction only]; Region: COG0714
637905006532	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905006533	Walker A motif; other site
637905006534	ATP binding site [chemical binding]; other site
637905006535	Walker B motif; other site
637905006536	arginine finger; other site
637905006537	Protein of unknown function DUF58; Region: DUF58; pfam01882
637905006538	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
637905006539	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
637905006540	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
637905006541	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
637905006542	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
637905006543	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
637905006544	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
637905006545	Part of AAA domain; Region: AAA_19; pfam13245
637905006546	Family description; Region: UvrD_C_2; pfam13538
637905006547	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
637905006548	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
637905006549	AAA domain; Region: AAA_30; pfam13604
637905006550	Family description; Region: UvrD_C_2; pfam13538
637905006551	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
637905006552	EamA-like transporter family; Region: EamA; pfam00892
637905006553	EamA-like transporter family; Region: EamA; pfam00892
637905006554	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
637905006555	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
637905006556	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
637905006557	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
637905006558	ATP-grasp domain; Region: ATP-grasp_4; cl17255
637905006559	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
637905006560	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
637905006561	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
637905006562	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905006563	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
637905006564	substrate binding pocket [chemical binding]; other site
637905006565	dimerization interface [polypeptide binding]; other site
637905006566	Protein of unknown function (Duf2374); Region: DUF2374; pfam09574
637905006567	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
637905006568	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
637905006569	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
637905006570	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
637905006571	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
637905006572	[4Fe-4S] binding site [ion binding]; other site
637905006573	molybdopterin cofactor binding site; other site
637905006574	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
637905006575	molybdopterin cofactor binding site; other site
637905006576	NapD protein; Region: NapD; pfam03927
637905006577	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
637905006578	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637905006579	ATP binding site [chemical binding]; other site
637905006580	putative Mg++ binding site [ion binding]; other site
637905006581	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905006582	nucleotide binding region [chemical binding]; other site
637905006583	ATP-binding site [chemical binding]; other site
637905006584	Helicase associated domain (HA2); Region: HA2; pfam04408
637905006585	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
637905006586	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
637905006587	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
637905006588	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
637905006589	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
637905006590	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
637905006591	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
637905006592	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
637905006593	Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275
637905006594	active site
637905006595	septation ring formation regulator EzrA; Provisional; Region: PRK04778
637905006596	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
637905006597	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
637905006598	putative hydrophobic ligand binding site [chemical binding]; other site
637905006599	protein interface [polypeptide binding]; other site
637905006600	gate; other site
637905006601	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
637905006602	putative hydrophobic ligand binding site [chemical binding]; other site
637905006603	protein interface [polypeptide binding]; other site
637905006604	gate; other site
637905006605	C2 domain; Region: C2; cd00030
637905006606	Lipoxygenase; Region: Lipoxygenase; pfam00305
637905006607	Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199
637905006608	active site
637905006609	nucleophile elbow; other site
637905006610	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
637905006611	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
637905006612	FMN binding site [chemical binding]; other site
637905006613	active site
637905006614	substrate binding site [chemical binding]; other site
637905006615	catalytic residue [active]
637905006616	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
637905006617	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
637905006618	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
637905006619	Ligand Binding Site [chemical binding]; other site
637905006620	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
637905006621	Ligand Binding Site [chemical binding]; other site
637905006622	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
637905006623	NAD(P) binding site [chemical binding]; other site
637905006624	catalytic residues [active]
637905006625	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
637905006626	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
637905006627	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
637905006628	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
637905006629	Methyltransferase domain; Region: Methyltransf_23; pfam13489
637905006630	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905006631	S-adenosylmethionine binding site [chemical binding]; other site
637905006632	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
637905006633	DNA-binding site [nucleotide binding]; DNA binding site
637905006634	RNA-binding motif; other site
637905006635	FOG: CBS domain [General function prediction only]; Region: COG0517
637905006636	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629
637905006637	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
637905006638	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
637905006639	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905006640	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
637905006641	dimerization interface [polypeptide binding]; other site
637905006642	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
637905006643	catalytic nucleophile [active]
637905006644	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
637905006645	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
637905006646	Surface antigen; Region: Bac_surface_Ag; pfam01103
637905006647	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
637905006648	Family of unknown function (DUF490); Region: DUF490; pfam04357
637905006649	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
637905006650	fatty acid metabolism regulator; Provisional; Region: PRK04984
637905006651	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
637905006652	DNA-binding site [nucleotide binding]; DNA binding site
637905006653	FadR C-terminal domain; Region: FadR_C; pfam07840
637905006654	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
637905006655	disulfide bond formation protein B; Provisional; Region: PRK01749
637905006656	hypothetical protein; Provisional; Region: PRK05170
637905006657	Transglycosylase SLT domain; Region: SLT_2; pfam13406
637905006658	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
637905006659	N-acetyl-D-glucosamine binding site [chemical binding]; other site
637905006660	YcgL domain; Region: YcgL; pfam05166
637905006661	septum formation inhibitor; Reviewed; Region: minC; PRK04804
637905006662	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
637905006663	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
637905006664	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
637905006665	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
637905006666	Switch I; other site
637905006667	Switch II; other site
637905006668	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
637905006669	ribonuclease D; Region: rnd; TIGR01388
637905006670	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
637905006671	catalytic site [active]
637905006672	putative active site [active]
637905006673	putative substrate binding site [chemical binding]; other site
637905006674	HRDC domain; Region: HRDC; pfam00570
637905006675	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
637905006676	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
637905006677	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
637905006678	acyl-activating enzyme (AAE) consensus motif; other site
637905006679	putative AMP binding site [chemical binding]; other site
637905006680	putative active site [active]
637905006681	putative CoA binding site [chemical binding]; other site
637905006682	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
637905006683	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
637905006684	Predicted methyltransferase [General function prediction only]; Region: COG4798
637905006685	Methyltransferase domain; Region: Methyltransf_23; pfam13489
637905006686	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
637905006687	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
637905006688	Glycoprotease family; Region: Peptidase_M22; pfam00814
637905006689	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
637905006690	catalytic triad [active]
637905006691	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
637905006692	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
637905006693	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
637905006694	DEAD/DEAH box helicase; Region: DEAD; pfam00270
637905006695	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
637905006696	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
637905006697	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
637905006698	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
637905006699	Zn2+ binding site [ion binding]; other site
637905006700	Mg2+ binding site [ion binding]; other site
637905006701	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
637905006702	YheO-like PAS domain; Region: PAS_6; pfam08348
637905006703	HTH domain; Region: HTH_22; pfam13309
637905006704	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
637905006705	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
637905006706	homotrimer interaction site [polypeptide binding]; other site
637905006707	putative active site [active]
637905006708	AzlC protein; Region: AzlC; pfam03591
637905006709	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
637905006710	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
637905006711	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
637905006712	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
637905006713	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
637905006714	histidinol dehydrogenase; Region: hisD; TIGR00069
637905006715	NAD binding site [chemical binding]; other site
637905006716	dimerization interface [polypeptide binding]; other site
637905006717	product binding site; other site
637905006718	substrate binding site [chemical binding]; other site
637905006719	zinc binding site [ion binding]; other site
637905006720	catalytic residues [active]
637905006721	histidinol-phosphate aminotransferase; Provisional; Region: PRK04635
637905006722	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
637905006723	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905006724	homodimer interface [polypeptide binding]; other site
637905006725	catalytic residue [active]
637905006726	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
637905006727	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
637905006728	active site
637905006729	motif I; other site
637905006730	motif II; other site
637905006731	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
637905006732	putative active site pocket [active]
637905006733	4-fold oligomerization interface [polypeptide binding]; other site
637905006734	metal binding residues [ion binding]; metal-binding site
637905006735	3-fold/trimer interface [polypeptide binding]; other site
637905006736	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
637905006737	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
637905006738	putative active site [active]
637905006739	oxyanion strand; other site
637905006740	catalytic triad [active]
637905006741	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
637905006742	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
637905006743	catalytic residues [active]
637905006744	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
637905006745	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
637905006746	substrate binding site [chemical binding]; other site
637905006747	glutamase interaction surface [polypeptide binding]; other site
637905006748	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
637905006749	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
637905006750	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
637905006751	metal binding site [ion binding]; metal-binding site
637905006752	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
637905006753	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
637905006754	substrate binding pocket [chemical binding]; other site
637905006755	membrane-bound complex binding site; other site
637905006756	hinge residues; other site
637905006757	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
637905006758	ATP binding site [chemical binding]; other site
637905006759	active site
637905006760	substrate binding site [chemical binding]; other site
637905006761	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
637905006762	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
637905006763	Putative transposase; Region: Y2_Tnp; pfam04986
637905006764	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
637905006765	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
637905006766	active site
637905006767	DNA binding site [nucleotide binding]
637905006768	Int/Topo IB signature motif; other site
637905006769	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
637905006770	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905006771	N-terminal plug; other site
637905006772	ligand-binding site [chemical binding]; other site
637905006773	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
637905006774	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
637905006775	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
637905006776	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
637905006777	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
637905006778	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
637905006779	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
637905006780	putative acyl-acceptor binding pocket; other site
637905006781	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
637905006782	IHF dimer interface [polypeptide binding]; other site
637905006783	IHF - DNA interface [nucleotide binding]; other site
637905006784	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
637905006785	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
637905006786	putative tRNA-binding site [nucleotide binding]; other site
637905006787	B3/4 domain; Region: B3_4; pfam03483
637905006788	tRNA synthetase B5 domain; Region: B5; smart00874
637905006789	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
637905006790	dimer interface [polypeptide binding]; other site
637905006791	motif 1; other site
637905006792	motif 3; other site
637905006793	motif 2; other site
637905006794	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
637905006795	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
637905006796	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
637905006797	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
637905006798	dimer interface [polypeptide binding]; other site
637905006799	motif 1; other site
637905006800	active site
637905006801	motif 2; other site
637905006802	motif 3; other site
637905006803	Cache domain; Region: Cache_1; pfam02743
637905006804	PAS domain; Region: PAS_9; pfam13426
637905006805	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
637905006806	putative active site [active]
637905006807	heme pocket [chemical binding]; other site
637905006808	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
637905006809	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905006810	ATP binding site [chemical binding]; other site
637905006811	Mg2+ binding site [ion binding]; other site
637905006812	G-X-G motif; other site
637905006813	Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682
637905006814	Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682
637905006815	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
637905006816	Protein of unknown function (DUF3802); Region: DUF3802; pfam12290
637905006817	YceI-like domain; Region: YceI; pfam04264
637905006818	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
637905006819	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
637905006820	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
637905006821	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
637905006822	agmatinase; Region: agmatinase; TIGR01230
637905006823	oligomer interface [polypeptide binding]; other site
637905006824	putative active site [active]
637905006825	Mn binding site [ion binding]; other site
637905006826	Adenosylmethionine decarboxylase; Region: SAM_decarbox; cl03253
637905006827	arginine decarboxylase; Provisional; Region: PRK05354
637905006828	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
637905006829	dimer interface [polypeptide binding]; other site
637905006830	active site
637905006831	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
637905006832	catalytic residues [active]
637905006833	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
637905006834	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
637905006835	S1 domain; Region: S1_2; pfam13509
637905006836	S1 domain; Region: S1_2; pfam13509
637905006837	hypothetical protein; Provisional; Region: PRK11239
637905006838	Protein of unknown function, DUF480; Region: DUF480; pfam04337
637905006839	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
637905006840	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
637905006841	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637905006842	Walker A/P-loop; other site
637905006843	ATP binding site [chemical binding]; other site
637905006844	Q-loop/lid; other site
637905006845	ABC transporter signature motif; other site
637905006846	Walker B; other site
637905006847	D-loop; other site
637905006848	H-loop/switch region; other site
637905006849	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
637905006850	DNA-binding site [nucleotide binding]; DNA binding site
637905006851	RNA-binding motif; other site
637905006852	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
637905006853	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905006854	S-adenosylmethionine binding site [chemical binding]; other site
637905006855	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
637905006856	S-adenosylmethionine binding site [chemical binding]; other site
637905006857	exonuclease I; Provisional; Region: sbcB; PRK11779
637905006858	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
637905006859	active site
637905006860	catalytic site [active]
637905006861	substrate binding site [chemical binding]; other site
637905006862	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
637905006863	cytidine deaminase; Provisional; Region: PRK09027
637905006864	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
637905006865	active site
637905006866	catalytic motif [active]
637905006867	Zn binding site [ion binding]; other site
637905006868	Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211
637905006869	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
637905006870	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
637905006871	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
637905006872	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
637905006873	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
637905006874	dimer interface [polypeptide binding]; other site
637905006875	active site
637905006876	acyl carrier protein; Provisional; Region: acpP; PRK00982
637905006877	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
637905006878	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
637905006879	NAD(P) binding site [chemical binding]; other site
637905006880	homotetramer interface [polypeptide binding]; other site
637905006881	homodimer interface [polypeptide binding]; other site
637905006882	active site
637905006883	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
637905006884	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
637905006885	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
637905006886	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
637905006887	dimer interface [polypeptide binding]; other site
637905006888	active site
637905006889	CoA binding pocket [chemical binding]; other site
637905006890	putative phosphate acyltransferase; Provisional; Region: PRK05331
637905006891	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
637905006892	hypothetical protein; Provisional; Region: PRK11193
637905006893	Maf-like protein; Region: Maf; pfam02545
637905006894	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
637905006895	active site
637905006896	dimer interface [polypeptide binding]; other site
637905006897	PAS domain; Region: PAS_10; pfam13596
637905006898	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
637905006899	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
637905006900	motif II; other site
637905006901	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
637905006902	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
637905006903	RNA binding surface [nucleotide binding]; other site
637905006904	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
637905006905	active site
637905006906	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
637905006907	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
637905006908	homodimer interface [polypeptide binding]; other site
637905006909	oligonucleotide binding site [chemical binding]; other site
637905006910	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
637905006911	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
637905006912	Sulfate transporter family; Region: Sulfate_transp; pfam00916
637905006913	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
637905006914	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
637905006915	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
637905006916	methionine sulfoxide reductase A; Provisional; Region: PRK14054
637905006917	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
637905006918	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
637905006919	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
637905006920	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
637905006921	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
637905006922	GTP/Mg2+ binding site [chemical binding]; other site
637905006923	G4 box; other site
637905006924	G5 box; other site
637905006925	G1 box; other site
637905006926	Switch I region; other site
637905006927	G2 box; other site
637905006928	G3 box; other site
637905006929	Switch II region; other site
637905006930	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
637905006931	Low molecular weight phosphatase family; Region: LMWPc; cd00115
637905006932	active site
637905006933	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
637905006934	Interdomain contacts; other site
637905006935	Cytokine receptor motif; other site
637905006936	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
637905006937	Interdomain contacts; other site
637905006938	Cytokine receptor motif; other site
637905006939	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
637905006940	active site
637905006941	DNA ligase; Provisional; Region: PRK09125
637905006942	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
637905006943	active site
637905006944	DNA binding site [nucleotide binding]
637905006945	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
637905006946	DNA binding site [nucleotide binding]
637905006947	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
637905006948	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
637905006949	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
637905006950	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
637905006951	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905006952	S-adenosylmethionine binding site [chemical binding]; other site
637905006953	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
637905006954	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
637905006955	active site
637905006956	PilZ domain; Region: PilZ; cl01260
637905006957	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
637905006958	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
637905006959	thymidylate kinase; Validated; Region: tmk; PRK00698
637905006960	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
637905006961	TMP-binding site; other site
637905006962	ATP-binding site [chemical binding]; other site
637905006963	YceG-like family; Region: YceG; pfam02618
637905006964	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
637905006965	dimerization interface [polypeptide binding]; other site
637905006966	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
637905006967	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
637905006968	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905006969	catalytic residue [active]
637905006970	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
637905006971	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
637905006972	ATP-binding site [chemical binding]; other site
637905006973	Sugar specificity; other site
637905006974	Pyrimidine base specificity; other site
637905006975	potential frameshift: common BLAST hit: gi|170726331|ref|YP_001760357.1| ATP-binding Mrp/Nbp35 family protein
637905006976	antiporter inner membrane protein; Provisional; Region: PRK11670
637905006977	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
637905006978	Walker A motif; other site
637905006979	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
637905006980	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
637905006981	active site
637905006982	HIGH motif; other site
637905006983	KMSKS motif; other site
637905006984	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
637905006985	tRNA binding surface [nucleotide binding]; other site
637905006986	anticodon binding site; other site
637905006987	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
637905006988	dimer interface [polypeptide binding]; other site
637905006989	putative tRNA-binding site [nucleotide binding]; other site
637905006990	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
637905006991	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
637905006992	active site residue [active]
637905006993	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
637905006994	active site residue [active]
637905006995	CreA protein; Region: CreA; pfam05981
637905006996	potential frameshift: common BLAST hit: gi|170726327|ref|YP_001760353.1|  chaperone
637905006997	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
637905006998	putative NEF/HSP70 interaction site [polypeptide binding]; other site
637905006999	nucleotide binding site [chemical binding]; other site
637905007000	SBD interface [polypeptide binding]; other site
637905007001	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
637905007002	nucleotide binding site [chemical binding]; other site
637905007003	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
637905007004	putative deacylase active site [active]
637905007005	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
637905007006	dimer interface [polypeptide binding]; other site
637905007007	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
637905007008	active site residues [active]
637905007009	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
637905007010	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
637905007011	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
637905007012	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
637905007013	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
637905007014	active site residue [active]
637905007015	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
637905007016	GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060
637905007017	putative GSH binding site (G-site) [chemical binding]; other site
637905007018	active site cysteine [active]
637905007019	putative C-terminal domain interface [polypeptide binding]; other site
637905007020	putative dimer interface [polypeptide binding]; other site
637905007021	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
637905007022	putative N-terminal domain interface [polypeptide binding]; other site
637905007023	putative dimer interface [polypeptide binding]; other site
637905007024	putative substrate binding pocket (H-site) [chemical binding]; other site
637905007025	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
637905007026	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637905007027	Coenzyme A binding pocket [chemical binding]; other site
637905007028	Predicted metalloprotease [General function prediction only]; Region: COG2321
637905007029	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
637905007030	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905007031	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
637905007032	putative substrate translocation pore; other site
637905007033	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08979
637905007034	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
637905007035	PYR/PP interface [polypeptide binding]; other site
637905007036	dimer interface [polypeptide binding]; other site
637905007037	TPP binding site [chemical binding]; other site
637905007038	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
637905007039	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
637905007040	TPP-binding site [chemical binding]; other site
637905007041	dimer interface [polypeptide binding]; other site
637905007042	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
637905007043	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
637905007044	putative valine binding site [chemical binding]; other site
637905007045	dimer interface [polypeptide binding]; other site
637905007046	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
637905007047	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
637905007048	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
637905007049	putative dimer interface [polypeptide binding]; other site
637905007050	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
637905007051	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
637905007052	active site
637905007053	metal binding site [ion binding]; metal-binding site
637905007054	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
637905007055	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
637905007056	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
637905007057	active site
637905007058	metal binding site [ion binding]; metal-binding site
637905007059	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
637905007060	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
637905007061	putative hydrolase; Provisional; Region: PRK11460
637905007062	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
637905007063	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
637905007064	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
637905007065	putative dimer interface [polypeptide binding]; other site
637905007066	N-terminal domain interface [polypeptide binding]; other site
637905007067	putative substrate binding pocket (H-site) [chemical binding]; other site
637905007068	Protein of unknown function (DUF3389); Region: DUF3389; pfam11869
637905007069	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
637905007070	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
637905007071	Transglycosylase SLT domain; Region: SLT_2; pfam13406
637905007072	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
637905007073	N-acetyl-D-glucosamine binding site [chemical binding]; other site
637905007074	catalytic residue [active]
637905007075	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
637905007076	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
637905007077	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
637905007078	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
637905007079	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905007080	active site
637905007081	phosphorylation site [posttranslational modification]
637905007082	intermolecular recognition site; other site
637905007083	dimerization interface [polypeptide binding]; other site
637905007084	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
637905007085	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
637905007086	hypothetical protein; Provisional; Region: PRK11770
637905007087	Domain of unknown function (DUF307); Region: DUF307; pfam03733
637905007088	Domain of unknown function (DUF307); Region: DUF307; pfam03733
637905007089	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
637905007090	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
637905007091	membrane-bound complex binding site; other site
637905007092	hinge residues; other site
637905007093	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905007094	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905007095	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
637905007096	dimerization interface [polypeptide binding]; other site
637905007097	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
637905007098	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
637905007099	dimer interface [polypeptide binding]; other site
637905007100	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
637905007101	active site
637905007102	Fe binding site [ion binding]; other site
637905007103	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
637905007104	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
637905007105	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
637905007106	Protein of unknown function, DUF482; Region: DUF482; pfam04339
637905007107	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
637905007108	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
637905007109	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
637905007110	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
637905007111	active site
637905007112	Zn binding site [ion binding]; other site
637905007113	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
637905007114	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
637905007115	active site
637905007116	metal binding site [ion binding]; metal-binding site
637905007117	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
637905007118	Uncharacterized conserved protein [Function unknown]; Region: COG3791
637905007119	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
637905007120	OsmC-like protein; Region: OsmC; cl00767
637905007121	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
637905007122	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
637905007123	Coenzyme A binding pocket [chemical binding]; other site
637905007124	Protein of unknown function (DUF938); Region: DUF938; pfam06080
637905007125	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905007126	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905007127	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
637905007128	putative effector binding pocket; other site
637905007129	dimerization interface [polypeptide binding]; other site
637905007130	Uncharacterized conserved protein [Function unknown]; Region: COG1359
637905007131	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
637905007132	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
637905007133	homotrimer interaction site [polypeptide binding]; other site
637905007134	putative active site [active]
637905007135	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
637905007136	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
637905007137	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
637905007138	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
637905007139	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
637905007140	substrate binding site [chemical binding]; other site
637905007141	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
637905007142	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
637905007143	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
637905007144	active site
637905007145	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
637905007146	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
637905007147	active site
637905007148	phosphate binding residues; other site
637905007149	catalytic residues [active]
637905007150	Dicarboxylate transport; Region: DctA-YdbH; pfam11739
637905007151	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
637905007152	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
637905007153	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
637905007154	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
637905007155	generic binding surface I; other site
637905007156	generic binding surface II; other site
637905007157	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
637905007158	putative active site [active]
637905007159	putative catalytic site [active]
637905007160	putative Mg binding site IVb [ion binding]; other site
637905007161	putative phosphate binding site [ion binding]; other site
637905007162	putative DNA binding site [nucleotide binding]; other site
637905007163	putative Mg binding site IVa [ion binding]; other site
637905007164	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
637905007165	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
637905007166	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
637905007167	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
637905007168	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
637905007169	Uncharacterized conserved protein [Function unknown]; Region: COG3791
637905007170	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
637905007171	Putative transposase; Region: Y2_Tnp; pfam04986
637905007172	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
637905007173	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
637905007174	active site
637905007175	DNA binding site [nucleotide binding]
637905007176	Int/Topo IB signature motif; other site
637905007177	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
637905007178	aspartate racemase; Region: asp_race; TIGR00035
637905007179	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
637905007180	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
637905007181	short chain dehydrogenase; Validated; Region: PRK08264
637905007182	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
637905007183	NAD(P) binding site [chemical binding]; other site
637905007184	active site
637905007185	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
637905007186	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
637905007187	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
637905007188	Zn binding site [ion binding]; other site
637905007189	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
637905007190	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
637905007191	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905007192	N-terminal plug; other site
637905007193	ligand-binding site [chemical binding]; other site
637905007194	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
637905007195	Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919
637905007196	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
637905007197	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
637905007198	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
637905007199	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
637905007200	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
637905007201	FtsX-like permease family; Region: FtsX; pfam02687
637905007202	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
637905007203	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905007204	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
637905007205	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905007206	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
637905007207	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905007208	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
637905007209	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
637905007210	Walker A/P-loop; other site
637905007211	ATP binding site [chemical binding]; other site
637905007212	Q-loop/lid; other site
637905007213	ABC transporter signature motif; other site
637905007214	Walker B; other site
637905007215	D-loop; other site
637905007216	H-loop/switch region; other site
637905007217	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
637905007218	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
637905007219	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
637905007220	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
637905007221	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
637905007222	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
637905007223	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
637905007224	putative FMN binding site [chemical binding]; other site
637905007225	Predicted membrane protein [Function unknown]; Region: COG2259
637905007226	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
637905007227	active site
637905007228	ATP binding site [chemical binding]; other site
637905007229	Phosphotransferase enzyme family; Region: APH; pfam01636
637905007230	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
637905007231	substrate binding site [chemical binding]; other site
637905007232	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
637905007233	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
637905007234	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905007235	N-terminal plug; other site
637905007236	ligand-binding site [chemical binding]; other site
637905007237	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
637905007238	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
637905007239	putative dimer interface [polypeptide binding]; other site
637905007240	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
637905007241	CoenzymeA binding site [chemical binding]; other site
637905007242	subunit interaction site [polypeptide binding]; other site
637905007243	PHB binding site; other site
637905007244	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
637905007245	CoenzymeA binding site [chemical binding]; other site
637905007246	subunit interaction site [polypeptide binding]; other site
637905007247	PHB binding site; other site
637905007248	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
637905007249	nucleotide binding site/active site [active]
637905007250	HIT family signature motif; other site
637905007251	catalytic residue [active]
637905007252	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
637905007253	Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082
637905007254	Curli assembly protein CsgE; Region: CsgE; pfam10627
637905007255	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
637905007256	DNA binding residues [nucleotide binding]
637905007257	dimerization interface [polypeptide binding]; other site
637905007258	major curlin subunit; Provisional; Region: csgA; PRK10051
637905007259	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
637905007260	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
637905007261	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
637905007262	major curlin subunit; Provisional; Region: csgA; PRK10051
637905007263	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
637905007264	major curlin subunit; Provisional; Region: csgA; PRK10051
637905007265	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
637905007266	active site
637905007267	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
637905007268	Catalytic domain of Protein Kinases; Region: PKc; cd00180
637905007269	active site
637905007270	ATP binding site [chemical binding]; other site
637905007271	substrate binding site [chemical binding]; other site
637905007272	activation loop (A-loop); other site
637905007273	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905007274	putative substrate translocation pore; other site
637905007275	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905007276	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
637905007277	nitrite reductase subunit NirD; Provisional; Region: PRK14989
637905007278	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
637905007279	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
637905007280	ANTAR domain; Region: ANTAR; pfam03861
637905007281	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
637905007282	hypothetical protein; Validated; Region: PRK09071
637905007283	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
637905007284	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
637905007285	active site
637905007286	SAM binding site [chemical binding]; other site
637905007287	homodimer interface [polypeptide binding]; other site
637905007288	heat shock protein HtpX; Provisional; Region: PRK05457
637905007289	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
637905007290	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
637905007291	AAA domain; Region: AAA_26; pfam13500
637905007292	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
637905007293	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905007294	S-adenosylmethionine binding site [chemical binding]; other site
637905007295	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
637905007296	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
637905007297	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
637905007298	catalytic residue [active]
637905007299	biotin synthase; Provisional; Region: PRK15108
637905007300	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637905007301	FeS/SAM binding site; other site
637905007302	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
637905007303	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
637905007304	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
637905007305	inhibitor-cofactor binding pocket; inhibition site
637905007306	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905007307	catalytic residue [active]
637905007308	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
637905007309	4Fe-4S binding domain; Region: Fer4; pfam00037
637905007310	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
637905007311	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
637905007312	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
637905007313	[4Fe-4S] binding site [ion binding]; other site
637905007314	molybdopterin cofactor binding site; other site
637905007315	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
637905007316	molybdopterin cofactor binding site; other site
637905007317	ecotin; Provisional; Region: PRK03719
637905007318	secondary substrate binding site; other site
637905007319	primary substrate binding site; other site
637905007320	inhibition loop; other site
637905007321	dimerization interface [polypeptide binding]; other site
637905007322	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
637905007323	Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055
637905007324	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
637905007325	Catalytic site [active]
637905007326	AAA domain; Region: AAA_33; pfam13671
637905007327	NAD-dependent deacetylase; Provisional; Region: PRK00481
637905007328	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
637905007329	NAD+ binding site [chemical binding]; other site
637905007330	substrate binding site [chemical binding]; other site
637905007331	Zn binding site [ion binding]; other site
637905007332	ferric uptake regulator; Provisional; Region: fur; PRK09462
637905007333	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
637905007334	metal binding site 2 [ion binding]; metal-binding site
637905007335	putative DNA binding helix; other site
637905007336	metal binding site 1 [ion binding]; metal-binding site
637905007337	dimer interface [polypeptide binding]; other site
637905007338	structural Zn2+ binding site [ion binding]; other site
637905007339	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
637905007340	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
637905007341	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
637905007342	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
637905007343	active site
637905007344	FMN binding site [chemical binding]; other site
637905007345	substrate binding site [chemical binding]; other site
637905007346	3Fe-4S cluster binding site [ion binding]; other site
637905007347	Predicted permeases [General function prediction only]; Region: COG0679
637905007348	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
637905007349	CoA binding domain; Region: CoA_binding; pfam02629
637905007350	CoA-ligase; Region: Ligase_CoA; pfam00549
637905007351	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
637905007352	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
637905007353	CoA-ligase; Region: Ligase_CoA; pfam00549
637905007354	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
637905007355	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
637905007356	E3 interaction surface; other site
637905007357	lipoyl attachment site [posttranslational modification]; other site
637905007358	e3 binding domain; Region: E3_binding; pfam02817
637905007359	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
637905007360	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
637905007361	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
637905007362	TPP-binding site [chemical binding]; other site
637905007363	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
637905007364	dimer interface [polypeptide binding]; other site
637905007365	PYR/PP interface [polypeptide binding]; other site
637905007366	TPP binding site [chemical binding]; other site
637905007367	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
637905007368	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
637905007369	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
637905007370	L-aspartate oxidase; Provisional; Region: PRK06175
637905007371	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
637905007372	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
637905007373	cardiolipin binding site; other site
637905007374	SdhC subunit interface [polypeptide binding]; other site
637905007375	proximal heme binding site [chemical binding]; other site
637905007376	Iron-sulfur protein interface; other site
637905007377	proximal quinone binding site [chemical binding]; other site
637905007378	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
637905007379	Iron-sulfur protein interface; other site
637905007380	proximal quinone binding site [chemical binding]; other site
637905007381	SdhD (CybS) interface [polypeptide binding]; other site
637905007382	proximal heme binding site [chemical binding]; other site
637905007383	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
637905007384	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
637905007385	dimer interface [polypeptide binding]; other site
637905007386	active site
637905007387	citrylCoA binding site [chemical binding]; other site
637905007388	NADH binding [chemical binding]; other site
637905007389	cationic pore residues; other site
637905007390	oxalacetate/citrate binding site [chemical binding]; other site
637905007391	coenzyme A binding site [chemical binding]; other site
637905007392	catalytic triad [active]
637905007393	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
637905007394	Domain of unknown function (DUF3859); Region: DUF3859; pfam12975
637905007395	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
637905007396	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637905007397	Coenzyme A binding pocket [chemical binding]; other site
637905007398	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
637905007399	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637905007400	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905007401	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
637905007402	Protein export membrane protein; Region: SecD_SecF; cl14618
637905007403	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
637905007404	Protein export membrane protein; Region: SecD_SecF; cl14618
637905007405	Uncharacterized conserved protein [Function unknown]; Region: COG2835
637905007406	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
637905007407	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
637905007408	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
637905007409	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
637905007410	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
637905007411	Walker A/P-loop; other site
637905007412	ATP binding site [chemical binding]; other site
637905007413	Q-loop/lid; other site
637905007414	ABC transporter signature motif; other site
637905007415	Walker B; other site
637905007416	D-loop; other site
637905007417	H-loop/switch region; other site
637905007418	ComEC family competence protein; Provisional; Region: PRK11539
637905007419	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
637905007420	Competence protein; Region: Competence; pfam03772
637905007421	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
637905007422	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
637905007423	potential frameshift: common BLAST hit: gi|157375964|ref|YP_001474564.1| LolC/E family lipoprotein releasing system, transmembrane protein
637905007424	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
637905007425	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
637905007426	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
637905007427	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
637905007428	Walker A/P-loop; other site
637905007429	ATP binding site [chemical binding]; other site
637905007430	Q-loop/lid; other site
637905007431	ABC transporter signature motif; other site
637905007432	Walker B; other site
637905007433	D-loop; other site
637905007434	H-loop/switch region; other site
637905007435	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
637905007436	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
637905007437	FtsX-like permease family; Region: FtsX; pfam02687
637905007438	transcription-repair coupling factor; Provisional; Region: PRK10689
637905007439	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
637905007440	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637905007441	ATP binding site [chemical binding]; other site
637905007442	putative Mg++ binding site [ion binding]; other site
637905007443	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905007444	nucleotide binding region [chemical binding]; other site
637905007445	ATP-binding site [chemical binding]; other site
637905007446	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
637905007447	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
637905007448	acylphosphatase; Provisional; Region: PRK14429
637905007449	hypothetical protein; Provisional; Region: PRK04940
637905007450	beta-hexosaminidase; Provisional; Region: PRK05337
637905007451	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
637905007452	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
637905007453	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
637905007454	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
637905007455	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
637905007456	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905007457	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
637905007458	substrate binding site [chemical binding]; other site
637905007459	dimerization interface [polypeptide binding]; other site
637905007460	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
637905007461	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
637905007462	active site
637905007463	interdomain interaction site; other site
637905007464	putative metal-binding site [ion binding]; other site
637905007465	nucleotide binding site [chemical binding]; other site
637905007466	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
637905007467	domain I; other site
637905007468	DNA binding groove [nucleotide binding]
637905007469	phosphate binding site [ion binding]; other site
637905007470	domain II; other site
637905007471	domain III; other site
637905007472	nucleotide binding site [chemical binding]; other site
637905007473	catalytic site [active]
637905007474	domain IV; other site
637905007475	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
637905007476	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
637905007477	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
637905007478	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
637905007479	succinylarginine dihydrolase; Provisional; Region: PRK13281
637905007480	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
637905007481	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
637905007482	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
637905007483	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
637905007484	inosine/guanosine kinase; Provisional; Region: PRK15074
637905007485	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
637905007486	substrate binding site [chemical binding]; other site
637905007487	ATP binding site [chemical binding]; other site
637905007488	ferrochelatase; Reviewed; Region: hemH; PRK00035
637905007489	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
637905007490	C-terminal domain interface [polypeptide binding]; other site
637905007491	active site
637905007492	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
637905007493	active site
637905007494	N-terminal domain interface [polypeptide binding]; other site
637905007495	adenylate kinase; Reviewed; Region: adk; PRK00279
637905007496	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
637905007497	AMP-binding site [chemical binding]; other site
637905007498	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
637905007499	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
637905007500	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
637905007501	heat shock protein 90; Provisional; Region: PRK05218
637905007502	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905007503	ATP binding site [chemical binding]; other site
637905007504	Mg2+ binding site [ion binding]; other site
637905007505	G-X-G motif; other site
637905007506	recombination protein RecR; Reviewed; Region: recR; PRK00076
637905007507	RecR protein; Region: RecR; pfam02132
637905007508	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
637905007509	putative active site [active]
637905007510	putative metal-binding site [ion binding]; other site
637905007511	tetramer interface [polypeptide binding]; other site
637905007512	hypothetical protein; Validated; Region: PRK00153
637905007513	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14949
637905007514	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905007515	Walker A motif; other site
637905007516	ATP binding site [chemical binding]; other site
637905007517	Walker B motif; other site
637905007518	arginine finger; other site
637905007519	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
637905007520	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
637905007521	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
637905007522	active site
637905007523	hypothetical protein; Provisional; Region: PRK10527
637905007524	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
637905007525	hypothetical protein; Provisional; Region: PRK05409
637905007526	MAEBL; Provisional; Region: PTZ00121
637905007527	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
637905007528	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
637905007529	FMN binding site [chemical binding]; other site
637905007530	active site
637905007531	catalytic residues [active]
637905007532	substrate binding site [chemical binding]; other site
637905007533	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
637905007534	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
637905007535	putative inner membrane peptidase; Provisional; Region: PRK11778
637905007536	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
637905007537	tandem repeat interface [polypeptide binding]; other site
637905007538	oligomer interface [polypeptide binding]; other site
637905007539	active site residues [active]
637905007540	extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502
637905007541	Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262
637905007542	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
637905007543	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
637905007544	NAD(P) binding site [chemical binding]; other site
637905007545	active site
637905007546	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
637905007547	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
637905007548	RNA binding surface [nucleotide binding]; other site
637905007549	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
637905007550	probable active site [active]
637905007551	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
637905007552	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
637905007553	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
637905007554	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
637905007555	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
637905007556	active site
637905007557	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
637905007558	anthranilate synthase component I; Provisional; Region: PRK13564
637905007559	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
637905007560	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
637905007561	Glutamine amidotransferase class-I; Region: GATase; pfam00117
637905007562	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
637905007563	glutamine binding [chemical binding]; other site
637905007564	catalytic triad [active]
637905007565	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
637905007566	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
637905007567	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
637905007568	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
637905007569	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
637905007570	active site
637905007571	ribulose/triose binding site [chemical binding]; other site
637905007572	phosphate binding site [ion binding]; other site
637905007573	substrate (anthranilate) binding pocket [chemical binding]; other site
637905007574	product (indole) binding pocket [chemical binding]; other site
637905007575	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
637905007576	active site
637905007577	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
637905007578	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
637905007579	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905007580	catalytic residue [active]
637905007581	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
637905007582	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
637905007583	substrate binding site [chemical binding]; other site
637905007584	active site
637905007585	catalytic residues [active]
637905007586	heterodimer interface [polypeptide binding]; other site
637905007587	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
637905007588	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
637905007589	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
637905007590	AAA ATPase domain; Region: AAA_16; pfam13191
637905007591	intracellular septation protein A; Reviewed; Region: PRK00259
637905007592	YciI-like protein; Reviewed; Region: PRK11370
637905007593	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
637905007594	putative catalytic site [active]
637905007595	putative phosphate binding site [ion binding]; other site
637905007596	active site
637905007597	metal binding site A [ion binding]; metal-binding site
637905007598	DNA binding site [nucleotide binding]
637905007599	putative AP binding site [nucleotide binding]; other site
637905007600	putative metal binding site B [ion binding]; other site
637905007601	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
637905007602	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905007603	N-terminal plug; other site
637905007604	ligand-binding site [chemical binding]; other site
637905007605	long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492
637905007606	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
637905007607	acyl-activating enzyme (AAE) consensus motif; other site
637905007608	putative AMP binding site [chemical binding]; other site
637905007609	putative active site [active]
637905007610	putative CoA binding site [chemical binding]; other site
637905007611	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
637905007612	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
637905007613	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
637905007614	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
637905007615	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
637905007616	active site
637905007617	FMN binding site [chemical binding]; other site
637905007618	2,4-decadienoyl-CoA binding site; other site
637905007619	catalytic residue [active]
637905007620	4Fe-4S cluster binding site [ion binding]; other site
637905007621	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
637905007622	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
637905007623	HAMP domain; Region: HAMP; pfam00672
637905007624	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
637905007625	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905007626	dimer interface [polypeptide binding]; other site
637905007627	putative CheW interface [polypeptide binding]; other site
637905007628	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
637905007629	Predicted oxidoreductase [General function prediction only]; Region: COG3573
637905007630	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
637905007631	WRKY DNA -binding domain; Region: WRKY; cl03892
637905007632	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
637905007633	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
637905007634	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
637905007635	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
637905007636	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
637905007637	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
637905007638	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
637905007639	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
637905007640	catalytic loop [active]
637905007641	iron binding site [ion binding]; other site
637905007642	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
637905007643	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
637905007644	Ligand binding site; other site
637905007645	metal-binding site
637905007646	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
637905007647	XdhC Rossmann domain; Region: XdhC_C; pfam13478
637905007648	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
637905007649	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
637905007650	H-NS histone family; Region: Histone_HNS; pfam00816
637905007651	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637905007652	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
637905007653	DNA binding site [nucleotide binding]
637905007654	potential frameshift: common BLAST hit: gi|117676245|ref|YP_863821.1| IS4 family transposase
637905007655	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
637905007656	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
637905007657	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
637905007658	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
637905007659	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
637905007660	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
637905007661	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
637905007662	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
637905007663	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
637905007664	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
637905007665	putative active site [active]
637905007666	putative NTP binding site [chemical binding]; other site
637905007667	putative nucleic acid binding site [nucleotide binding]; other site
637905007668	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
637905007669	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
637905007670	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
637905007671	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
637905007672	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
637905007673	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
637905007674	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905007675	Response regulator receiver domain; Region: Response_reg; pfam00072
637905007676	active site
637905007677	phosphorylation site [posttranslational modification]
637905007678	intermolecular recognition site; other site
637905007679	dimerization interface [polypeptide binding]; other site
637905007680	Integrase core domain; Region: rve; pfam00665
637905007681	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
637905007682	dimer interface [polypeptide binding]; other site
637905007683	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
637905007684	metal binding site [ion binding]; metal-binding site
637905007685	SnoaL-like domain; Region: SnoaL_2; pfam12680
637905007686	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
637905007687	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
637905007688	Sodium Bile acid symporter family; Region: SBF; pfam01758
637905007689	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
637905007690	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637905007691	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905007692	Protein of unknown function (DUF2955); Region: DUF2955; pfam11168
637905007693	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
637905007694	MarR family; Region: MarR_2; pfam12802
637905007695	Protein of unknown function (DUF998); Region: DUF998; pfam06197
637905007696	potential frameshift: common BLAST hit: gi|152999276|ref|YP_001364957.1| GCN5-related N-acetyltransferase
637905007697	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637905007698	Coenzyme A binding pocket [chemical binding]; other site
637905007699	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
637905007700	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
637905007701	DNA topoisomerase III; Provisional; Region: PRK07726
637905007702	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
637905007703	active site
637905007704	putative interdomain interaction site [polypeptide binding]; other site
637905007705	putative metal-binding site [ion binding]; other site
637905007706	putative nucleotide binding site [chemical binding]; other site
637905007707	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
637905007708	domain I; other site
637905007709	DNA binding groove [nucleotide binding]
637905007710	phosphate binding site [ion binding]; other site
637905007711	domain II; other site
637905007712	domain III; other site
637905007713	nucleotide binding site [chemical binding]; other site
637905007714	catalytic site [active]
637905007715	domain IV; other site
637905007716	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231
637905007717	putative active site [active]
637905007718	Zn binding site [ion binding]; other site
637905007719	amidophosphoribosyltransferase; Provisional; Region: PRK09246
637905007720	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
637905007721	active site
637905007722	tetramer interface [polypeptide binding]; other site
637905007723	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
637905007724	active site
637905007725	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
637905007726	Colicin V production protein; Region: Colicin_V; cl00567
637905007727	cell division protein DedD; Provisional; Region: PRK11633
637905007728	Sporulation related domain; Region: SPOR; pfam05036
637905007729	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
637905007730	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
637905007731	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
637905007732	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
637905007733	dimerization interface 3.5A [polypeptide binding]; other site
637905007734	active site
637905007735	FimV N-terminal domain; Region: FimV_core; TIGR03505
637905007736	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
637905007737	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
637905007738	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
637905007739	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
637905007740	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
637905007741	ligand binding site [chemical binding]; other site
637905007742	NAD binding site [chemical binding]; other site
637905007743	catalytic site [active]
637905007744	homodimer interface [polypeptide binding]; other site
637905007745	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
637905007746	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905007747	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905007748	metal binding site [ion binding]; metal-binding site
637905007749	active site
637905007750	I-site; other site
637905007751	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
637905007752	HNH endonuclease; Region: HNH_2; pfam13391
637905007753	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
637905007754	Peptidase family U32; Region: Peptidase_U32; pfam01136
637905007755	Collagenase; Region: DUF3656; pfam12392
637905007756	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
637905007757	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
637905007758	dimer interface [polypeptide binding]; other site
637905007759	active site
637905007760	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
637905007761	tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197
637905007762	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
637905007763	YfcL protein; Region: YfcL; pfam08891
637905007764	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
637905007765	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905007766	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
637905007767	putative substrate translocation pore; other site
637905007768	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
637905007769	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
637905007770	Tetramer interface [polypeptide binding]; other site
637905007771	active site
637905007772	FMN-binding site [chemical binding]; other site
637905007773	HemK family putative methylases; Region: hemK_fam; TIGR00536
637905007774	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905007775	S-adenosylmethionine binding site [chemical binding]; other site
637905007776	hypothetical protein; Provisional; Region: PRK04946
637905007777	Smr domain; Region: Smr; pfam01713
637905007778	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
637905007779	catalytic core [active]
637905007780	Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025
637905007781	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
637905007782	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
637905007783	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
637905007784	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
637905007785	PAS fold; Region: PAS_3; pfam08447
637905007786	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
637905007787	PAS domain; Region: PAS_9; pfam13426
637905007788	putative active site [active]
637905007789	heme pocket [chemical binding]; other site
637905007790	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905007791	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905007792	metal binding site [ion binding]; metal-binding site
637905007793	active site
637905007794	I-site; other site
637905007795	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
637905007796	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
637905007797	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
637905007798	substrate binding site [chemical binding]; other site
637905007799	oxyanion hole (OAH) forming residues; other site
637905007800	trimer interface [polypeptide binding]; other site
637905007801	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
637905007802	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
637905007803	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
637905007804	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
637905007805	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
637905007806	dimer interface [polypeptide binding]; other site
637905007807	active site
637905007808	MoxR-like ATPases [General function prediction only]; Region: COG0714
637905007809	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905007810	Walker A motif; other site
637905007811	ATP binding site [chemical binding]; other site
637905007812	Walker B motif; other site
637905007813	arginine finger; other site
637905007814	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
637905007815	Protein of unknown function DUF58; Region: DUF58; pfam01882
637905007816	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
637905007817	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
637905007818	metal ion-dependent adhesion site (MIDAS); other site
637905007819	von Willebrand factor type A domain; Region: VWA_2; pfam13519
637905007820	metal ion-dependent adhesion site (MIDAS); other site
637905007821	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905007822	binding surface
637905007823	TPR motif; other site
637905007824	Tetratricopeptide repeat; Region: TPR_16; pfam13432
637905007825	Oxygen tolerance; Region: BatD; pfam13584
637905007826	RNA polymerase sigma factor; Provisional; Region: PRK12517
637905007827	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
637905007828	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
637905007829	DNA binding residues [nucleotide binding]
637905007830	Protein of unknown function (DUF3379); Region: DUF3379; pfam11859
637905007831	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
637905007832	Na binding site [ion binding]; other site
637905007833	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
637905007834	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
637905007835	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
637905007836	active site residue [active]
637905007837	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
637905007838	active site
637905007839	catalytic residues [active]
637905007840	PA_VapT_like: Protease-associated domain containing proteins like VapT from Vibrio metschnikovii strain RH530. This group contains various PA domain-containing proteins similar to V. metschnikovii VapT, including the serine alkaline protease SapSh from...; Region: PA_VapT_like; cd04817
637905007841	PA/subtilisin-like domain interface [polypeptide binding]; other site
637905007842	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
637905007843	catalytic residues [active]
637905007844	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
637905007845	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
637905007846	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
637905007847	malate synthase; Provisional; Region: PRK08951
637905007848	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
637905007849	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
637905007850	non-specific DNA binding site [nucleotide binding]; other site
637905007851	salt bridge; other site
637905007852	sequence-specific DNA binding site [nucleotide binding]; other site
637905007853	Domain of unknown function (DUF955); Region: DUF955; cl01076
637905007854	Protein of unknown function (DUF3612); Region: DUF3612; pfam12268
637905007855	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
637905007856	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
637905007857	putative NAD(P) binding site [chemical binding]; other site
637905007858	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905007859	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905007860	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
637905007861	putative effector binding pocket; other site
637905007862	dimerization interface [polypeptide binding]; other site
637905007863	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
637905007864	dimerization interface [polypeptide binding]; other site
637905007865	active site
637905007866	hypothetical protein; Provisional; Region: PRK11020
637905007867	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
637905007868	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637905007869	FeS/SAM binding site; other site
637905007870	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
637905007871	ATP cone domain; Region: ATP-cone; pfam03477
637905007872	Class III ribonucleotide reductase; Region: RNR_III; cd01675
637905007873	effector binding site; other site
637905007874	active site
637905007875	Zn binding site [ion binding]; other site
637905007876	glycine loop; other site
637905007877	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
637905007878	Prostaglandin dehydrogenases; Region: PGDH; cd05288
637905007879	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
637905007880	NAD(P) binding site [chemical binding]; other site
637905007881	substrate binding site [chemical binding]; other site
637905007882	dimer interface [polypeptide binding]; other site
637905007883	hypothetical protein; Provisional; Region: PRK10279
637905007884	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
637905007885	active site
637905007886	nucleophile elbow; other site
637905007887	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
637905007888	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
637905007889	ligand binding site [chemical binding]; other site
637905007890	potential frameshift: common BLAST hit: gi|157374733|ref|YP_001473333.1| DEAD/DEAH box helicase domain-containing protein
637905007891	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
637905007892	DEAD-like helicases superfamily; Region: DEXDc; smart00487
637905007893	ATP binding site [chemical binding]; other site
637905007894	Mg++ binding site [ion binding]; other site
637905007895	motif III; other site
637905007896	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905007897	nucleotide binding region [chemical binding]; other site
637905007898	ATP-binding site [chemical binding]; other site
637905007899	Protein of unknown function (DUF3010); Region: DUF3010; pfam11215
637905007900	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
637905007901	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
637905007902	substrate binding pocket [chemical binding]; other site
637905007903	membrane-bound complex binding site; other site
637905007904	hinge residues; other site
637905007905	Helix-turn-helix domain; Region: HTH_18; pfam12833
637905007906	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
637905007907	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
637905007908	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
637905007909	PA14 domain; Region: PA14; cl08459
637905007910	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
637905007911	putative peptidase; Provisional; Region: PRK11649
637905007912	Peptidase family M23; Region: Peptidase_M23; pfam01551
637905007913	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
637905007914	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
637905007915	Walker A/P-loop; other site
637905007916	ATP binding site [chemical binding]; other site
637905007917	Q-loop/lid; other site
637905007918	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
637905007919	ABC transporter signature motif; other site
637905007920	Walker B; other site
637905007921	D-loop; other site
637905007922	H-loop/switch region; other site
637905007923	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
637905007924	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
637905007925	active site
637905007926	metal binding site [ion binding]; metal-binding site
637905007927	DNA binding site [nucleotide binding]
637905007928	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
637905007929	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
637905007930	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
637905007931	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905007932	homodimer interface [polypeptide binding]; other site
637905007933	catalytic residue [active]
637905007934	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
637905007935	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905007936	dimerization interface [polypeptide binding]; other site
637905007937	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905007938	dimer interface [polypeptide binding]; other site
637905007939	putative CheW interface [polypeptide binding]; other site
637905007940	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
637905007941	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905007942	dimerization interface [polypeptide binding]; other site
637905007943	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905007944	dimer interface [polypeptide binding]; other site
637905007945	putative CheW interface [polypeptide binding]; other site
637905007946	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268
637905007947	putative substrate binding pocket [chemical binding]; other site
637905007948	trimer interface [polypeptide binding]; other site
637905007949	hypothetical protein; Provisional; Region: PRK10621
637905007950	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
637905007951	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
637905007952	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905007953	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
637905007954	dimerization interface [polypeptide binding]; other site
637905007955	Nuclease-related domain; Region: NERD; pfam08378
637905007956	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
637905007957	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
637905007958	ATP binding site [chemical binding]; other site
637905007959	substrate binding site [chemical binding]; other site
637905007960	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
637905007961	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
637905007962	RNA binding surface [nucleotide binding]; other site
637905007963	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
637905007964	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
637905007965	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
637905007966	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
637905007967	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
637905007968	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905007969	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905007970	metal binding site [ion binding]; metal-binding site
637905007971	active site
637905007972	I-site; other site
637905007973	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905007974	TPR motif; other site
637905007975	binding surface
637905007976	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
637905007977	binding surface
637905007978	TPR motif; other site
637905007979	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
637905007980	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
637905007981	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
637905007982	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
637905007983	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
637905007984	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
637905007985	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
637905007986	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
637905007987	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905007988	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905007989	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
637905007990	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905007991	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
637905007992	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
637905007993	trimer interface [polypeptide binding]; other site
637905007994	eyelet of channel; other site
637905007995	DNA polymerase II; Reviewed; Region: PRK05762
637905007996	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
637905007997	active site
637905007998	catalytic site [active]
637905007999	substrate binding site [chemical binding]; other site
637905008000	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
637905008001	active site
637905008002	metal-binding site
637905008003	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
637905008004	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
637905008005	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
637905008006	hypothetical protein; Provisional; Region: PRK10621
637905008007	Primosomal replication protein priB and priC; Region: priB_priC; cl11483
637905008008	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
637905008009	Late competence development protein ComFB; Region: ComFB; pfam10719
637905008010	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
637905008011	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
637905008012	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
637905008013	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
637905008014	homodimer interface [polypeptide binding]; other site
637905008015	substrate-cofactor binding pocket; other site
637905008016	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905008017	catalytic residue [active]
637905008018	hypothetical protein; Provisional; Region: PRK05415
637905008019	Domain of unknown function (DUF697); Region: DUF697; cl12064
637905008020	YcjX-like family, DUF463; Region: DUF463; pfam04317
637905008021	PspC domain; Region: PspC; cl00864
637905008022	phage shock protein C; Region: phageshock_pspC; TIGR02978
637905008023	phage shock protein B; Provisional; Region: pspB; PRK09458
637905008024	phage shock protein A; Region: phageshock_pspA; TIGR02977
637905008025	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
637905008026	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905008027	Walker A motif; other site
637905008028	ATP binding site [chemical binding]; other site
637905008029	Walker B motif; other site
637905008030	arginine finger; other site
637905008031	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
637905008032	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
637905008033	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
637905008034	peptide binding site [polypeptide binding]; other site
637905008035	antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110
637905008036	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
637905008037	dimer interface [polypeptide binding]; other site
637905008038	conserved gate region; other site
637905008039	putative PBP binding loops; other site
637905008040	ABC-ATPase subunit interface; other site
637905008041	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171
637905008042	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
637905008043	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
637905008044	dimer interface [polypeptide binding]; other site
637905008045	conserved gate region; other site
637905008046	putative PBP binding loops; other site
637905008047	ABC-ATPase subunit interface; other site
637905008048	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170
637905008049	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
637905008050	Walker A/P-loop; other site
637905008051	ATP binding site [chemical binding]; other site
637905008052	Q-loop/lid; other site
637905008053	ABC transporter signature motif; other site
637905008054	Walker B; other site
637905008055	D-loop; other site
637905008056	H-loop/switch region; other site
637905008057	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
637905008058	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167
637905008059	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
637905008060	Walker A/P-loop; other site
637905008061	ATP binding site [chemical binding]; other site
637905008062	Q-loop/lid; other site
637905008063	ABC transporter signature motif; other site
637905008064	Walker B; other site
637905008065	D-loop; other site
637905008066	H-loop/switch region; other site
637905008067	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
637905008068	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
637905008069	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
637905008070	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
637905008071	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
637905008072	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
637905008073	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
637905008074	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
637905008075	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
637905008076	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
637905008077	periplasmic folding chaperone; Provisional; Region: PRK10788
637905008078	SurA N-terminal domain; Region: SurA_N_3; cl07813
637905008079	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
637905008080	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
637905008081	IHF dimer interface [polypeptide binding]; other site
637905008082	IHF - DNA interface [nucleotide binding]; other site
637905008083	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
637905008084	Found in ATP-dependent protease La (LON); Region: LON; smart00464
637905008085	Found in ATP-dependent protease La (LON); Region: LON; smart00464
637905008086	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905008087	Walker A motif; other site
637905008088	ATP binding site [chemical binding]; other site
637905008089	Walker B motif; other site
637905008090	arginine finger; other site
637905008091	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
637905008092	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
637905008093	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
637905008094	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905008095	Walker A motif; other site
637905008096	ATP binding site [chemical binding]; other site
637905008097	Walker B motif; other site
637905008098	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
637905008099	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
637905008100	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
637905008101	oligomer interface [polypeptide binding]; other site
637905008102	active site residues [active]
637905008103	trigger factor; Provisional; Region: tig; PRK01490
637905008104	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
637905008105	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
637905008106	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
637905008107	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
637905008108	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
637905008109	homodimer interface [polypeptide binding]; other site
637905008110	NADP binding site [chemical binding]; other site
637905008111	substrate binding site [chemical binding]; other site
637905008112	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
637905008113	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
637905008114	active site
637905008115	HIGH motif; other site
637905008116	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
637905008117	KMSKS motif; other site
637905008118	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
637905008119	tRNA binding surface [nucleotide binding]; other site
637905008120	anticodon binding site; other site
637905008121	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
637905008122	substrate binding site [chemical binding]; other site
637905008123	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
637905008124	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
637905008125	putative active site [active]
637905008126	putative metal binding site [ion binding]; other site
637905008127	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
637905008128	active site
637905008129	dinuclear metal binding site [ion binding]; other site
637905008130	dimerization interface [polypeptide binding]; other site
637905008131	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
637905008132	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
637905008133	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
637905008134	active site
637905008135	HIGH motif; other site
637905008136	nucleotide binding site [chemical binding]; other site
637905008137	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
637905008138	KMSKS motif; other site
637905008139	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
637905008140	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
637905008141	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
637905008142	G1 box; other site
637905008143	GTP/Mg2+ binding site [chemical binding]; other site
637905008144	Switch I region; other site
637905008145	G2 box; other site
637905008146	G3 box; other site
637905008147	Switch II region; other site
637905008148	G4 box; other site
637905008149	G5 box; other site
637905008150	Nucleoside recognition; Region: Gate; pfam07670
637905008151	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
637905008152	FeoA domain; Region: FeoA; pfam04023
637905008153	GAF domain; Region: GAF; pfam01590
637905008154	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905008155	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905008156	metal binding site [ion binding]; metal-binding site
637905008157	active site
637905008158	I-site; other site
637905008159	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
637905008160	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
637905008161	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
637905008162	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
637905008163	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
637905008164	putative pyridoxal-dependent aspartate 1-decarboxylase; Region: NOD_PanD_pyr; TIGR03799
637905008165	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
637905008166	catalytic residue [active]
637905008167	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
637905008168	active site
637905008169	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
637905008170	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
637905008171	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
637905008172	metal binding site [ion binding]; metal-binding site
637905008173	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
637905008174	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
637905008175	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
637905008176	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
637905008177	ABC-ATPase subunit  interface; other site
637905008178	dimer interface [polypeptide binding]; other site
637905008179	putative PBP binding regions; other site
637905008180	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
637905008181	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
637905008182	ABC-ATPase subunit  interface; other site
637905008183	dimer interface [polypeptide binding]; other site
637905008184	putative PBP binding regions; other site
637905008185	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
637905008186	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
637905008187	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
637905008188	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
637905008189	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
637905008190	AzlC protein; Region: AzlC; pfam03591
637905008191	Predicted membrane protein [Function unknown]; Region: COG4392
637905008192	NIPSNAP; Region: NIPSNAP; pfam07978
637905008193	Predicted transcriptional regulator [Transcription]; Region: COG2378
637905008194	HTH domain; Region: HTH_11; pfam08279
637905008195	WYL domain; Region: WYL; pfam13280
637905008196	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
637905008197	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
637905008198	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
637905008199	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
637905008200	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
637905008201	active site
637905008202	substrate binding site [chemical binding]; other site
637905008203	metal binding site [ion binding]; metal-binding site
637905008204	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
637905008205	active site
637905008206	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
637905008207	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
637905008208	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
637905008209	NAD(P) binding site [chemical binding]; other site
637905008210	active site
637905008211	peptide synthase; Provisional; Region: PRK09274
637905008212	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910
637905008213	acyl-activating enzyme (AAE) consensus motif; other site
637905008214	putative AMP binding site [chemical binding]; other site
637905008215	putative active site [active]
637905008216	putative CoA binding site [chemical binding]; other site
637905008217	haloalkane dehalogenase; Provisional; Region: PRK03592
637905008218	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258
637905008219	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
637905008220	dimer interface [polypeptide binding]; other site
637905008221	active site
637905008222	CoA binding pocket [chemical binding]; other site
637905008223	Methyltransferase domain; Region: Methyltransf_32; pfam13679
637905008224	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
637905008225	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
637905008226	active site
637905008227	potential frameshift: common BLAST hit: gi|157374644|ref|YP_001473244.1| choline/carnitine/betaine transporter
637905008228	BCCT family transporter; Region: BCCT; pfam02028
637905008229	BCCT family transporter; Region: BCCT; cl00569
637905008230	transcriptional regulator PhoU; Provisional; Region: PRK11115
637905008231	PhoU domain; Region: PhoU; pfam01895
637905008232	PhoU domain; Region: PhoU; pfam01895
637905008233	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
637905008234	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
637905008235	Walker A/P-loop; other site
637905008236	ATP binding site [chemical binding]; other site
637905008237	Q-loop/lid; other site
637905008238	ABC transporter signature motif; other site
637905008239	Walker B; other site
637905008240	D-loop; other site
637905008241	H-loop/switch region; other site
637905008242	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
637905008243	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
637905008244	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
637905008245	dimer interface [polypeptide binding]; other site
637905008246	conserved gate region; other site
637905008247	putative PBP binding loops; other site
637905008248	ABC-ATPase subunit interface; other site
637905008249	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
637905008250	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
637905008251	conserved gate region; other site
637905008252	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
637905008253	ABC-ATPase subunit interface; other site
637905008254	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
637905008255	ACT domain; Region: ACT_6; pfam13740
637905008256	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
637905008257	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
637905008258	Cupin domain; Region: Cupin_2; pfam07883
637905008259	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
637905008260	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905008261	N-terminal plug; other site
637905008262	ligand-binding site [chemical binding]; other site
637905008263	Lipase (class 2); Region: Lipase_2; pfam01674
637905008264	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
637905008265	lipase chaperone; Provisional; Region: PRK01294
637905008266	Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280
637905008267	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
637905008268	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
637905008269	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
637905008270	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637905008271	Coenzyme A binding pocket [chemical binding]; other site
637905008272	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
637905008273	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
637905008274	active site
637905008275	RNA/DNA hybrid binding site [nucleotide binding]; other site
637905008276	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
637905008277	active site
637905008278	dinuclear metal binding site [ion binding]; other site
637905008279	dimerization interface [polypeptide binding]; other site
637905008280	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
637905008281	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
637905008282	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
637905008283	trimer interface [polypeptide binding]; other site
637905008284	active site
637905008285	substrate binding site [chemical binding]; other site
637905008286	CoA binding site [chemical binding]; other site
637905008287	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
637905008288	nucleotide binding site/active site [active]
637905008289	HIT family signature motif; other site
637905008290	catalytic residue [active]
637905008291	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
637905008292	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905008293	TPR motif; other site
637905008294	Tetratricopeptide repeat; Region: TPR_16; pfam13432
637905008295	binding surface
637905008296	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
637905008297	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
637905008298	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
637905008299	substrate binding site [chemical binding]; other site
637905008300	ligand binding site [chemical binding]; other site
637905008301	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
637905008302	substrate binding site [chemical binding]; other site
637905008303	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
637905008304	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
637905008305	dimer interface [polypeptide binding]; other site
637905008306	active site
637905008307	citrylCoA binding site [chemical binding]; other site
637905008308	oxalacetate/citrate binding site [chemical binding]; other site
637905008309	coenzyme A binding site [chemical binding]; other site
637905008310	catalytic triad [active]
637905008311	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
637905008312	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
637905008313	tetramer interface [polypeptide binding]; other site
637905008314	active site
637905008315	Mg2+/Mn2+ binding site [ion binding]; other site
637905008316	Transcriptional regulators [Transcription]; Region: GntR; COG1802
637905008317	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
637905008318	DNA-binding site [nucleotide binding]; DNA binding site
637905008319	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
637905008320	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
637905008321	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905008322	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905008323	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
637905008324	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
637905008325	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
637905008326	interface (dimer of trimers) [polypeptide binding]; other site
637905008327	Substrate-binding/catalytic site; other site
637905008328	Zn-binding sites [ion binding]; other site
637905008329	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
637905008330	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
637905008331	Nucleoside recognition; Region: Gate; pfam07670
637905008332	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
637905008333	putative S-transferase; Provisional; Region: PRK11752
637905008334	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
637905008335	C-terminal domain interface [polypeptide binding]; other site
637905008336	GSH binding site (G-site) [chemical binding]; other site
637905008337	dimer interface [polypeptide binding]; other site
637905008338	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
637905008339	dimer interface [polypeptide binding]; other site
637905008340	N-terminal domain interface [polypeptide binding]; other site
637905008341	active site
637905008342	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
637905008343	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637905008344	Walker A/P-loop; other site
637905008345	ATP binding site [chemical binding]; other site
637905008346	Q-loop/lid; other site
637905008347	ABC transporter signature motif; other site
637905008348	Walker B; other site
637905008349	D-loop; other site
637905008350	H-loop/switch region; other site
637905008351	ABC transporter; Region: ABC_tran_2; pfam12848
637905008352	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
637905008353	copper exporting ATPase; Provisional; Region: copA; PRK10671
637905008354	copper exporting ATPase; Provisional; Region: copA; PRK10671
637905008355	copper exporting ATPase; Provisional; Region: copA; PRK10671
637905008356	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
637905008357	Heavy-metal-associated domain; Region: HMA; pfam00403
637905008358	metal-binding site [ion binding]
637905008359	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
637905008360	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
637905008361	motif II; other site
637905008362	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
637905008363	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
637905008364	DNA binding residues [nucleotide binding]
637905008365	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
637905008366	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
637905008367	NAD(P) binding site [chemical binding]; other site
637905008368	active site
637905008369	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
637905008370	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
637905008371	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
637905008372	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
637905008373	substrate binding site [chemical binding]; other site
637905008374	oxyanion hole (OAH) forming residues; other site
637905008375	trimer interface [polypeptide binding]; other site
637905008376	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
637905008377	enoyl-CoA hydratase; Provisional; Region: PRK09076
637905008378	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
637905008379	substrate binding site [chemical binding]; other site
637905008380	oxyanion hole (OAH) forming residues; other site
637905008381	trimer interface [polypeptide binding]; other site
637905008382	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
637905008383	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
637905008384	substrate binding pocket [chemical binding]; other site
637905008385	FAD binding site [chemical binding]; other site
637905008386	catalytic base [active]
637905008387	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
637905008388	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
637905008389	tetrameric interface [polypeptide binding]; other site
637905008390	NAD binding site [chemical binding]; other site
637905008391	catalytic residues [active]
637905008392	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
637905008393	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
637905008394	dimer interface [polypeptide binding]; other site
637905008395	active site
637905008396	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
637905008397	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
637905008398	homoserine O-succinyltransferase; Provisional; Region: PRK05368
637905008399	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
637905008400	proposed active site lysine [active]
637905008401	conserved cys residue [active]
637905008402	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
637905008403	outer membrane protein W; Provisional; Region: PRK10959
637905008404	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
637905008405	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
637905008406	acyl-CoA thioesterase II; Provisional; Region: PRK10526
637905008407	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
637905008408	active site
637905008409	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
637905008410	catalytic triad [active]
637905008411	dimer interface [polypeptide binding]; other site
637905008412	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
637905008413	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
637905008414	NAD(P) binding site [chemical binding]; other site
637905008415	active site
637905008416	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
637905008417	UbiA prenyltransferase family; Region: UbiA; pfam01040
637905008418	Protein of unknown function (DUF3624); Region: DUF3624; pfam12292
637905008419	Leucine rich repeat; Region: LRR_8; pfam13855
637905008420	Leucine rich repeat; Region: LRR_8; pfam13855
637905008421	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
637905008422	active site
637905008423	ATP binding site [chemical binding]; other site
637905008424	substrate binding site [chemical binding]; other site
637905008425	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
637905008426	activation loop (A-loop); other site
637905008427	activation loop (A-loop); other site
637905008428	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637905008429	Coenzyme A binding pocket [chemical binding]; other site
637905008430	potential frameshift: common BLAST hit: gi|170727557|ref|YP_001761583.1| peptidase U32
637905008431	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
637905008432	Peptidase family U32; Region: Peptidase_U32; pfam01136
637905008433	Collagenase; Region: DUF3656; pfam12392
637905008434	Peptidase family U32; Region: Peptidase_U32; cl03113
637905008435	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
637905008436	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
637905008437	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
637905008438	putative N-terminal domain interface [polypeptide binding]; other site
637905008439	putative dimer interface [polypeptide binding]; other site
637905008440	putative substrate binding pocket (H-site) [chemical binding]; other site
637905008441	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
637905008442	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
637905008443	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
637905008444	active site
637905008445	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
637905008446	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
637905008447	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
637905008448	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
637905008449	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
637905008450	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
637905008451	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
637905008452	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
637905008453	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
637905008454	dimer interface [polypeptide binding]; other site
637905008455	active site
637905008456	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
637905008457	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
637905008458	substrate binding site [chemical binding]; other site
637905008459	oxyanion hole (OAH) forming residues; other site
637905008460	trimer interface [polypeptide binding]; other site
637905008461	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
637905008462	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
637905008463	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
637905008464	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
637905008465	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
637905008466	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
637905008467	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
637905008468	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
637905008469	active site
637905008470	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
637905008471	30S subunit binding site; other site
637905008472	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
637905008473	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
637905008474	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
637905008475	OsmC-like protein; Region: OsmC; cl00767
637905008476	Domain of unknown function DUF20; Region: UPF0118; pfam01594
637905008477	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
637905008478	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
637905008479	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
637905008480	active site
637905008481	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
637905008482	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
637905008483	structural tetrad; other site
637905008484	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
637905008485	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
637905008486	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
637905008487	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
637905008488	protein binding site [polypeptide binding]; other site
637905008489	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
637905008490	Domain interface; other site
637905008491	Peptide binding site; other site
637905008492	Active site tetrad [active]
637905008493	RNA polymerase sigma factor; Provisional; Region: PRK12513
637905008494	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
637905008495	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
637905008496	DNA binding residues [nucleotide binding]
637905008497	von Willebrand factor; Region: vWF_A; pfam12450
637905008498	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
637905008499	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
637905008500	metal ion-dependent adhesion site (MIDAS); other site
637905008501	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
637905008502	AIR carboxylase; Region: AIRC; pfam00731
637905008503	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
637905008504	N-acetyl-D-glucosamine binding site [chemical binding]; other site
637905008505	catalytic residue [active]
637905008506	glutamate--cysteine ligase; Provisional; Region: PRK02107
637905008507	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
637905008508	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
637905008509	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
637905008510	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
637905008511	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
637905008512	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
637905008513	Predicted membrane protein [Function unknown]; Region: COG1238
637905008514	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
637905008515	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
637905008516	SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102
637905008517	SEC-C motif; Region: SEC-C; pfam02810
637905008518	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
637905008519	oxaloacetate decarboxylase; Provisional; Region: PRK14040
637905008520	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
637905008521	active site
637905008522	catalytic residues [active]
637905008523	metal binding site [ion binding]; metal-binding site
637905008524	homodimer binding site [polypeptide binding]; other site
637905008525	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
637905008526	carboxyltransferase (CT) interaction site; other site
637905008527	biotinylation site [posttranslational modification]; other site
637905008528	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
637905008529	carbon storage regulator; Provisional; Region: PRK01712
637905008530	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
637905008531	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
637905008532	motif 1; other site
637905008533	active site
637905008534	motif 2; other site
637905008535	motif 3; other site
637905008536	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
637905008537	DHHA1 domain; Region: DHHA1; pfam02272
637905008538	recombinase A; Provisional; Region: recA; PRK09354
637905008539	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
637905008540	hexamer interface [polypeptide binding]; other site
637905008541	Walker A motif; other site
637905008542	ATP binding site [chemical binding]; other site
637905008543	Walker B motif; other site
637905008544	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
637905008545	MutS domain I; Region: MutS_I; pfam01624
637905008546	MutS domain II; Region: MutS_II; pfam05188
637905008547	MutS domain III; Region: MutS_III; pfam05192
637905008548	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
637905008549	Walker A/P-loop; other site
637905008550	ATP binding site [chemical binding]; other site
637905008551	Q-loop/lid; other site
637905008552	ABC transporter signature motif; other site
637905008553	Walker B; other site
637905008554	D-loop; other site
637905008555	H-loop/switch region; other site
637905008556	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
637905008557	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
637905008558	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
637905008559	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
637905008560	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
637905008561	DNA binding residues [nucleotide binding]
637905008562	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
637905008563	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
637905008564	Peptidase family M23; Region: Peptidase_M23; pfam01551
637905008565	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
637905008566	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905008567	S-adenosylmethionine binding site [chemical binding]; other site
637905008568	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
637905008569	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
637905008570	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
637905008571	Permutation of conserved domain; other site
637905008572	active site
637905008573	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
637905008574	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
637905008575	homotrimer interaction site [polypeptide binding]; other site
637905008576	zinc binding site [ion binding]; other site
637905008577	CDP-binding sites; other site
637905008578	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
637905008579	substrate binding site; other site
637905008580	dimer interface; other site
637905008581	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
637905008582	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
637905008583	enolase; Provisional; Region: eno; PRK00077
637905008584	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
637905008585	dimer interface [polypeptide binding]; other site
637905008586	metal binding site [ion binding]; metal-binding site
637905008587	substrate binding pocket [chemical binding]; other site
637905008588	CTP synthetase; Validated; Region: pyrG; PRK05380
637905008589	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
637905008590	Catalytic site [active]
637905008591	active site
637905008592	UTP binding site [chemical binding]; other site
637905008593	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
637905008594	active site
637905008595	putative oxyanion hole; other site
637905008596	catalytic triad [active]
637905008597	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
637905008598	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
637905008599	homodimer interface [polypeptide binding]; other site
637905008600	metal binding site [ion binding]; metal-binding site
637905008601	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
637905008602	homodimer interface [polypeptide binding]; other site
637905008603	active site
637905008604	putative chemical substrate binding site [chemical binding]; other site
637905008605	metal binding site [ion binding]; metal-binding site
637905008606	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
637905008607	HD domain; Region: HD_4; pfam13328
637905008608	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
637905008609	synthetase active site [active]
637905008610	NTP binding site [chemical binding]; other site
637905008611	metal binding site [ion binding]; metal-binding site
637905008612	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
637905008613	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
637905008614	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
637905008615	TRAM domain; Region: TRAM; pfam01938
637905008616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905008617	S-adenosylmethionine binding site [chemical binding]; other site
637905008618	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
637905008619	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
637905008620	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905008621	dimerization interface [polypeptide binding]; other site
637905008622	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
637905008623	dimer interface [polypeptide binding]; other site
637905008624	phosphorylation site [posttranslational modification]
637905008625	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905008626	ATP binding site [chemical binding]; other site
637905008627	Mg2+ binding site [ion binding]; other site
637905008628	G-X-G motif; other site
637905008629	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905008630	active site
637905008631	phosphorylation site [posttranslational modification]
637905008632	intermolecular recognition site; other site
637905008633	dimerization interface [polypeptide binding]; other site
637905008634	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
637905008635	putative binding surface; other site
637905008636	active site
637905008637	Protein of unknown function (DUF416); Region: DUF416; pfam04222
637905008638	Protein of unknown function (DUF3319); Region: DUF3319; pfam11782
637905008639	recombination and repair protein; Provisional; Region: PRK10869
637905008640	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
637905008641	Walker A/P-loop; other site
637905008642	ATP binding site [chemical binding]; other site
637905008643	Q-loop/lid; other site
637905008644	The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397
637905008645	coregulator recognition site; other site
637905008646	ligand binding site [chemical binding]; other site
637905008647	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
637905008648	ABC transporter signature motif; other site
637905008649	Walker B; other site
637905008650	D-loop; other site
637905008651	H-loop/switch region; other site
637905008652	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
637905008653	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
637905008654	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
637905008655	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
637905008656	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
637905008657	catalytic triad [active]
637905008658	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
637905008659	MOSC domain; Region: MOSC; pfam03473
637905008660	3-alpha domain; Region: 3-alpha; pfam03475
637905008661	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
637905008662	tetramer interfaces [polypeptide binding]; other site
637905008663	binuclear metal-binding site [ion binding]; other site
637905008664	thiamine monophosphate kinase; Provisional; Region: PRK05731
637905008665	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
637905008666	ATP binding site [chemical binding]; other site
637905008667	dimerization interface [polypeptide binding]; other site
637905008668	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
637905008669	putative RNA binding site [nucleotide binding]; other site
637905008670	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
637905008671	homopentamer interface [polypeptide binding]; other site
637905008672	active site
637905008673	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
637905008674	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
637905008675	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
637905008676	dimerization interface [polypeptide binding]; other site
637905008677	active site
637905008678	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
637905008679	Lumazine binding domain; Region: Lum_binding; pfam00677
637905008680	Lumazine binding domain; Region: Lum_binding; pfam00677
637905008681	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
637905008682	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
637905008683	catalytic motif [active]
637905008684	Zn binding site [ion binding]; other site
637905008685	RibD C-terminal domain; Region: RibD_C; cl17279
637905008686	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
637905008687	ATP cone domain; Region: ATP-cone; pfam03477
637905008688	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
637905008689	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
637905008690	dimer interface [polypeptide binding]; other site
637905008691	active site
637905008692	glycine-pyridoxal phosphate binding site [chemical binding]; other site
637905008693	folate binding site [chemical binding]; other site
637905008694	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
637905008695	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637905008696	Walker A/P-loop; other site
637905008697	ATP binding site [chemical binding]; other site
637905008698	Q-loop/lid; other site
637905008699	ABC transporter signature motif; other site
637905008700	Walker B; other site
637905008701	D-loop; other site
637905008702	H-loop/switch region; other site
637905008703	ABC transporter; Region: ABC_tran_2; pfam12848
637905008704	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
637905008705	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
637905008706	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
637905008707	aromatic chitin/cellulose binding site residues [chemical binding]; other site
637905008708	Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046
637905008709	aromatic chitin/cellulose binding site residues [chemical binding]; other site
637905008710	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
637905008711	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
637905008712	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
637905008713	putative active site [active]
637905008714	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
637905008715	Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425
637905008716	active site
637905008717	metal binding site [ion binding]; metal-binding site
637905008718	Protein of unknown function (DUF419); Region: DUF419; pfam04237
637905008719	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
637905008720	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
637905008721	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
637905008722	RNA binding surface [nucleotide binding]; other site
637905008723	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
637905008724	active site
637905008725	uracil binding [chemical binding]; other site
637905008726	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
637905008727	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905008728	N-terminal plug; other site
637905008729	ligand-binding site [chemical binding]; other site
637905008730	Helix-turn-helix domain; Region: HTH_18; pfam12833
637905008731	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
637905008732	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637905008733	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905008734	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
637905008735	Protein export membrane protein; Region: SecD_SecF; cl14618
637905008736	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905008737	Major Facilitator Superfamily; Region: MFS_1; pfam07690
637905008738	putative substrate translocation pore; other site
637905008739	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
637905008740	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
637905008741	homodimer interface [polypeptide binding]; other site
637905008742	substrate-cofactor binding pocket; other site
637905008743	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905008744	catalytic residue [active]
637905008745	NnrS protein; Region: NnrS; pfam05940
637905008746	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
637905008747	active site
637905008748	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
637905008749	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
637905008750	ATP binding site [chemical binding]; other site
637905008751	Mg++ binding site [ion binding]; other site
637905008752	motif III; other site
637905008753	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905008754	nucleotide binding region [chemical binding]; other site
637905008755	ATP-binding site [chemical binding]; other site
637905008756	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905008757	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
637905008758	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
637905008759	putative active site [active]
637905008760	heme pocket [chemical binding]; other site
637905008761	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
637905008762	putative active site [active]
637905008763	heme pocket [chemical binding]; other site
637905008764	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
637905008765	PAS domain; Region: PAS_9; pfam13426
637905008766	putative active site [active]
637905008767	heme pocket [chemical binding]; other site
637905008768	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905008769	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905008770	metal binding site [ion binding]; metal-binding site
637905008771	active site
637905008772	I-site; other site
637905008773	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
637905008774	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
637905008775	active site
637905008776	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905008777	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905008778	metal binding site [ion binding]; metal-binding site
637905008779	active site
637905008780	I-site; other site
637905008781	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
637905008782	HDOD domain; Region: HDOD; pfam08668
637905008783	putative protease; Provisional; Region: PRK15452
637905008784	Peptidase family U32; Region: Peptidase_U32; pfam01136
637905008785	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
637905008786	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
637905008787	metal-binding site [ion binding]
637905008788	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
637905008789	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
637905008790	DNA binding residues [nucleotide binding]
637905008791	dimer interface [polypeptide binding]; other site
637905008792	mercury binding site [ion binding]; other site
637905008793	SCP-2 sterol transfer family; Region: SCP2; cl01225
637905008794	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
637905008795	Peptidase family U32; Region: Peptidase_U32; pfam01136
637905008796	putative protease; Provisional; Region: PRK15447
637905008797	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
637905008798	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
637905008799	PAS domain; Region: PAS_9; pfam13426
637905008800	putative active site [active]
637905008801	heme pocket [chemical binding]; other site
637905008802	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
637905008803	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905008804	dimer interface [polypeptide binding]; other site
637905008805	putative CheW interface [polypeptide binding]; other site
637905008806	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
637905008807	Nucleoside recognition; Region: Gate; pfam07670
637905008808	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
637905008809	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
637905008810	PAS fold; Region: PAS_3; pfam08447
637905008811	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
637905008812	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905008813	ATP binding site [chemical binding]; other site
637905008814	Mg2+ binding site [ion binding]; other site
637905008815	G-X-G motif; other site
637905008816	FOG: CBS domain [General function prediction only]; Region: COG0517
637905008817	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_24; cd04637
637905008818	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
637905008819	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
637905008820	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
637905008821	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
637905008822	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
637905008823	molybdopterin cofactor binding site [chemical binding]; other site
637905008824	substrate binding site [chemical binding]; other site
637905008825	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
637905008826	molybdopterin cofactor binding site; other site
637905008827	chaperone protein TorD; Validated; Region: torD; PRK04976
637905008828	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
637905008829	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
637905008830	active site
637905008831	FMN binding site [chemical binding]; other site
637905008832	substrate binding site [chemical binding]; other site
637905008833	catalytic residues [active]
637905008834	homodimer interface [polypeptide binding]; other site
637905008835	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
637905008836	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
637905008837	ATP binding site [chemical binding]; other site
637905008838	Mg++ binding site [ion binding]; other site
637905008839	motif III; other site
637905008840	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905008841	nucleotide binding region [chemical binding]; other site
637905008842	ATP-binding site [chemical binding]; other site
637905008843	TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956
637905008844	HAMP domain; Region: HAMP; pfam00672
637905008845	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
637905008846	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905008847	ATP binding site [chemical binding]; other site
637905008848	Mg2+ binding site [ion binding]; other site
637905008849	G-X-G motif; other site
637905008850	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905008851	active site
637905008852	phosphorylation site [posttranslational modification]
637905008853	intermolecular recognition site; other site
637905008854	dimerization interface [polypeptide binding]; other site
637905008855	TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936
637905008856	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
637905008857	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
637905008858	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905008859	active site
637905008860	phosphorylation site [posttranslational modification]
637905008861	intermolecular recognition site; other site
637905008862	dimerization interface [polypeptide binding]; other site
637905008863	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637905008864	DNA binding site [nucleotide binding]
637905008865	PilZ domain; Region: PilZ; pfam07238
637905008866	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
637905008867	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
637905008868	ligand binding site [chemical binding]; other site
637905008869	Predicted archaeal methyltransferase [General function prediction only]; Region: COG2521
637905008870	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905008871	S-adenosylmethionine binding site [chemical binding]; other site
637905008872	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
637905008873	Interdomain contacts; other site
637905008874	Cytokine receptor motif; other site
637905008875	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
637905008876	Protein of unknown function (DUF3703); Region: DUF3703; pfam12487
637905008877	DNA repair protein RadA; Provisional; Region: PRK11823
637905008878	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
637905008879	Walker A motif; other site
637905008880	ATP binding site [chemical binding]; other site
637905008881	Walker B motif; other site
637905008882	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
637905008883	PilZ domain; Region: PilZ; pfam07238
637905008884	PilZ domain; Region: PilZ; pfam07238
637905008885	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
637905008886	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
637905008887	phosphoserine phosphatase SerB; Region: serB; TIGR00338
637905008888	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
637905008889	motif II; other site
637905008890	Bacterial virulence factor haemolysin; Region: SMP_2; cl11479
637905008891	putative transposase OrfB; Reviewed; Region: PHA02517
637905008892	HTH-like domain; Region: HTH_21; pfam13276
637905008893	Integrase core domain; Region: rve; pfam00665
637905008894	Integrase core domain; Region: rve_3; pfam13683
637905008895	Transposase; Region: HTH_Tnp_1; pfam01527
637905008896	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
637905008897	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
637905008898	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
637905008899	phosphopentomutase; Provisional; Region: PRK05362
637905008900	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
637905008901	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
637905008902	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
637905008903	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
637905008904	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
637905008905	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
637905008906	intersubunit interface [polypeptide binding]; other site
637905008907	active site
637905008908	catalytic residue [active]
637905008909	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
637905008910	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
637905008911	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
637905008912	Nucleoside recognition; Region: Gate; pfam07670
637905008913	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
637905008914	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
637905008915	active site
637905008916	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
637905008917	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
637905008918	G1 box; other site
637905008919	putative GEF interaction site [polypeptide binding]; other site
637905008920	GTP/Mg2+ binding site [chemical binding]; other site
637905008921	Switch I region; other site
637905008922	G2 box; other site
637905008923	G3 box; other site
637905008924	Switch II region; other site
637905008925	G4 box; other site
637905008926	G5 box; other site
637905008927	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
637905008928	lipoprotein NlpI; Provisional; Region: PRK11189
637905008929	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905008930	binding surface
637905008931	TPR motif; other site
637905008932	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
637905008933	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
637905008934	RNase E interface [polypeptide binding]; other site
637905008935	trimer interface [polypeptide binding]; other site
637905008936	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
637905008937	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
637905008938	RNase E interface [polypeptide binding]; other site
637905008939	trimer interface [polypeptide binding]; other site
637905008940	active site
637905008941	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
637905008942	putative nucleic acid binding region [nucleotide binding]; other site
637905008943	G-X-X-G motif; other site
637905008944	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
637905008945	RNA binding site [nucleotide binding]; other site
637905008946	domain interface; other site
637905008947	biofilm formation regulator HmsP; Provisional; Region: PRK11829
637905008948	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905008949	metal binding site [ion binding]; metal-binding site
637905008950	active site
637905008951	I-site; other site
637905008952	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
637905008953	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
637905008954	16S/18S rRNA binding site [nucleotide binding]; other site
637905008955	S13e-L30e interaction site [polypeptide binding]; other site
637905008956	25S rRNA binding site [nucleotide binding]; other site
637905008957	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
637905008958	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
637905008959	RNA binding site [nucleotide binding]; other site
637905008960	active site
637905008961	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
637905008962	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
637905008963	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
637905008964	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
637905008965	translation initiation factor IF-2; Region: IF-2; TIGR00487
637905008966	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
637905008967	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
637905008968	G1 box; other site
637905008969	putative GEF interaction site [polypeptide binding]; other site
637905008970	GTP/Mg2+ binding site [chemical binding]; other site
637905008971	Switch I region; other site
637905008972	G2 box; other site
637905008973	G3 box; other site
637905008974	Switch II region; other site
637905008975	G4 box; other site
637905008976	G5 box; other site
637905008977	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
637905008978	Translation-initiation factor 2; Region: IF-2; pfam11987
637905008979	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
637905008980	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
637905008981	NusA N-terminal domain; Region: NusA_N; pfam08529
637905008982	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
637905008983	RNA binding site [nucleotide binding]; other site
637905008984	homodimer interface [polypeptide binding]; other site
637905008985	NusA-like KH domain; Region: KH_5; pfam13184
637905008986	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
637905008987	G-X-X-G motif; other site
637905008988	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
637905008989	ribosome maturation protein RimP; Reviewed; Region: PRK00092
637905008990	Sm and related proteins; Region: Sm_like; cl00259
637905008991	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
637905008992	putative oligomer interface [polypeptide binding]; other site
637905008993	putative RNA binding site [nucleotide binding]; other site
637905008994	Preprotein translocase SecG subunit; Region: SecG; pfam03840
637905008995	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
637905008996	triosephosphate isomerase; Provisional; Region: PRK14567
637905008997	substrate binding site [chemical binding]; other site
637905008998	dimer interface [polypeptide binding]; other site
637905008999	catalytic triad [active]
637905009000	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
637905009001	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
637905009002	active site
637905009003	substrate binding site [chemical binding]; other site
637905009004	metal binding site [ion binding]; metal-binding site
637905009005	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
637905009006	dihydropteroate synthase; Region: DHPS; TIGR01496
637905009007	substrate binding pocket [chemical binding]; other site
637905009008	dimer interface [polypeptide binding]; other site
637905009009	inhibitor binding site; inhibition site
637905009010	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
637905009011	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905009012	Walker A motif; other site
637905009013	ATP binding site [chemical binding]; other site
637905009014	Walker B motif; other site
637905009015	arginine finger; other site
637905009016	Peptidase family M41; Region: Peptidase_M41; pfam01434
637905009017	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
637905009018	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905009019	S-adenosylmethionine binding site [chemical binding]; other site
637905009020	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
637905009021	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13021
637905009022	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
637905009023	Protein export membrane protein; Region: SecD_SecF; pfam02355
637905009024	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK12933
637905009025	SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136
637905009026	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
637905009027	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
637905009028	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
637905009029	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
637905009030	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
637905009031	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905009032	dimerization interface [polypeptide binding]; other site
637905009033	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
637905009034	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905009035	dimer interface [polypeptide binding]; other site
637905009036	putative CheW interface [polypeptide binding]; other site
637905009037	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
637905009038	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
637905009039	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
637905009040	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
637905009041	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
637905009042	ATP-grasp domain; Region: ATP-grasp_4; cl17255
637905009043	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
637905009044	IMP binding site; other site
637905009045	dimer interface [polypeptide binding]; other site
637905009046	interdomain contacts; other site
637905009047	partial ornithine binding site; other site
637905009048	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
637905009049	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
637905009050	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
637905009051	catalytic site [active]
637905009052	subunit interface [polypeptide binding]; other site
637905009053	dihydrodipicolinate reductase; Provisional; Region: PRK00048
637905009054	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
637905009055	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
637905009056	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
637905009057	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
637905009058	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
637905009059	Peptidase family M48; Region: Peptidase_M48; pfam01435
637905009060	chaperone protein DnaJ; Provisional; Region: PRK10767
637905009061	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
637905009062	HSP70 interaction site [polypeptide binding]; other site
637905009063	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
637905009064	substrate binding site [polypeptide binding]; other site
637905009065	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
637905009066	Zn binding sites [ion binding]; other site
637905009067	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
637905009068	dimer interface [polypeptide binding]; other site
637905009069	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
637905009070	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
637905009071	nucleotide binding site [chemical binding]; other site
637905009072	EamA-like transporter family; Region: EamA; pfam00892
637905009073	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
637905009074	EamA-like transporter family; Region: EamA; pfam00892
637905009075	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
637905009076	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
637905009077	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
637905009078	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
637905009079	Coenzyme A binding pocket [chemical binding]; other site
637905009080	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
637905009081	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
637905009082	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
637905009083	putative catalytic cysteine [active]
637905009084	gamma-glutamyl kinase; Provisional; Region: PRK05429
637905009085	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
637905009086	nucleotide binding site [chemical binding]; other site
637905009087	homotetrameric interface [polypeptide binding]; other site
637905009088	putative phosphate binding site [ion binding]; other site
637905009089	putative allosteric binding site; other site
637905009090	PUA domain; Region: PUA; pfam01472
637905009091	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
637905009092	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
637905009093	interface (dimer of trimers) [polypeptide binding]; other site
637905009094	Substrate-binding/catalytic site; other site
637905009095	Zn-binding sites [ion binding]; other site
637905009096	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
637905009097	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
637905009098	metal binding site [ion binding]; metal-binding site
637905009099	dimer interface [polypeptide binding]; other site
637905009100	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
637905009101	active site
637905009102	DNA polymerase IV; Validated; Region: PRK02406
637905009103	DNA binding site [nucleotide binding]
637905009104	S-formylglutathione hydrolase; Region: PLN02442
637905009105	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
637905009106	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
637905009107	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
637905009108	substrate binding site [chemical binding]; other site
637905009109	catalytic Zn binding site [ion binding]; other site
637905009110	NAD binding site [chemical binding]; other site
637905009111	structural Zn binding site [ion binding]; other site
637905009112	dimer interface [polypeptide binding]; other site
637905009113	hypothetical protein; Provisional; Region: PRK11019
637905009114	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905009115	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905009116	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470
637905009117	putative effector binding pocket; other site
637905009118	putative dimerization interface [polypeptide binding]; other site
637905009119	Cache domain; Region: Cache_1; pfam02743
637905009120	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
637905009121	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905009122	dimerization interface [polypeptide binding]; other site
637905009123	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905009124	dimer interface [polypeptide binding]; other site
637905009125	putative CheW interface [polypeptide binding]; other site
637905009126	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991
637905009127	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
637905009128	ApbE family; Region: ApbE; pfam02424
637905009129	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
637905009130	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
637905009131	catalytic loop [active]
637905009132	iron binding site [ion binding]; other site
637905009133	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
637905009134	FAD binding pocket [chemical binding]; other site
637905009135	FAD binding motif [chemical binding]; other site
637905009136	phosphate binding motif [ion binding]; other site
637905009137	beta-alpha-beta structure motif; other site
637905009138	NAD binding pocket [chemical binding]; other site
637905009139	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
637905009140	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
637905009141	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
637905009142	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
637905009143	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
637905009144	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
637905009145	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
637905009146	S-ribosylhomocysteinase; Provisional; Region: PRK02260
637905009147	BolA-like protein; Region: BolA; cl00386
637905009148	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
637905009149	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
637905009150	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905009151	S-adenosylmethionine binding site [chemical binding]; other site
637905009152	Flagellin N-methylase; Region: FliB; cl00497
637905009153	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
637905009154	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
637905009155	Cupin domain; Region: Cupin_2; cl17218
637905009156	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
637905009157	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
637905009158	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
637905009159	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
637905009160	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG3056
637905009161	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
637905009162	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
637905009163	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
637905009164	substrate binding site [chemical binding]; other site
637905009165	muropeptide transporter; Reviewed; Region: ampG; PRK11902
637905009166	Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000
637905009167	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905009168	putative substrate translocation pore; other site
637905009169	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
637905009170	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
637905009171	Predicted integral membrane protein [Function unknown]; Region: COG5652
637905009172	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
637905009173	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
637905009174	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
637905009175	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
637905009176	Na2 binding site [ion binding]; other site
637905009177	putative substrate binding site 1 [chemical binding]; other site
637905009178	Na binding site 1 [ion binding]; other site
637905009179	putative substrate binding site 2 [chemical binding]; other site
637905009180	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
637905009181	active site
637905009182	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
637905009183	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
637905009184	Protein of unknown function (DUF819); Region: DUF819; cl02317
637905009185	Uncharacterized conserved protein [Function unknown]; Region: COG2912
637905009186	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
637905009187	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
637905009188	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
637905009189	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637905009190	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905009191	A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases.  Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417
637905009192	type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846
637905009193	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
637905009194	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637905009195	Walker A/P-loop; other site
637905009196	ATP binding site [chemical binding]; other site
637905009197	Q-loop/lid; other site
637905009198	ABC transporter signature motif; other site
637905009199	Walker B; other site
637905009200	D-loop; other site
637905009201	H-loop/switch region; other site
637905009202	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
637905009203	active site
637905009204	DNA binding site [nucleotide binding]
637905009205	Int/Topo IB signature motif; other site
637905009206	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
637905009207	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905009208	S-adenosylmethionine binding site [chemical binding]; other site
637905009209	peptide chain release factor 1; Validated; Region: prfA; PRK00591
637905009210	This domain is found in peptide chain release factors; Region: PCRF; smart00937
637905009211	RF-1 domain; Region: RF-1; pfam00472
637905009212	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
637905009213	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
637905009214	tRNA; other site
637905009215	putative tRNA binding site [nucleotide binding]; other site
637905009216	putative NADP binding site [chemical binding]; other site
637905009217	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
637905009218	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
637905009219	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
637905009220	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
637905009221	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
637905009222	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
637905009223	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
637905009224	active site
637905009225	GTP-binding protein YchF; Reviewed; Region: PRK09601
637905009226	YchF GTPase; Region: YchF; cd01900
637905009227	G1 box; other site
637905009228	GTP/Mg2+ binding site [chemical binding]; other site
637905009229	Switch I region; other site
637905009230	G2 box; other site
637905009231	Switch II region; other site
637905009232	G3 box; other site
637905009233	G4 box; other site
637905009234	G5 box; other site
637905009235	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
637905009236	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
637905009237	putative active site [active]
637905009238	catalytic residue [active]
637905009239	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK08849
637905009240	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
637905009241	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
637905009242	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
637905009243	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637905009244	FeS/SAM binding site; other site
637905009245	TRAM domain; Region: TRAM; pfam01938
637905009246	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
637905009247	PhoH-like protein; Region: PhoH; pfam02562
637905009248	metal-binding heat shock protein; Provisional; Region: PRK00016
637905009249	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
637905009250	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
637905009251	Transporter associated domain; Region: CorC_HlyC; smart01091
637905009252	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
637905009253	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
637905009254	putative active site [active]
637905009255	catalytic triad [active]
637905009256	putative dimer interface [polypeptide binding]; other site
637905009257	alpha-glucosidase; Provisional; Region: PRK10137
637905009258	Protein of unknown function (DUF1451); Region: DUF1451; pfam07295
637905009259	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
637905009260	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
637905009261	HIGH motif; other site
637905009262	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
637905009263	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
637905009264	active site
637905009265	KMSKS motif; other site
637905009266	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
637905009267	tRNA binding surface [nucleotide binding]; other site
637905009268	Lipopolysaccharide-assembly; Region: LptE; cl01125
637905009269	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
637905009270	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
637905009271	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
637905009272	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
637905009273	active site
637905009274	(T/H)XGH motif; other site
637905009275	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
637905009276	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
637905009277	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
637905009278	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
637905009279	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
637905009280	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
637905009281	Transglycosylase SLT domain; Region: SLT_2; pfam13406
637905009282	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
637905009283	N-acetyl-D-glucosamine binding site [chemical binding]; other site
637905009284	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
637905009285	rare lipoprotein A; Region: rlpA; TIGR00413
637905009286	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
637905009287	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
637905009288	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
637905009289	hypothetical protein; Provisional; Region: PRK04998
637905009290	lipoate-protein ligase B; Provisional; Region: PRK14342
637905009291	lipoyl synthase; Provisional; Region: PRK05481
637905009292	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637905009293	FeS/SAM binding site; other site
637905009294	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
637905009295	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637905009296	Coenzyme A binding pocket [chemical binding]; other site
637905009297	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
637905009298	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
637905009299	dimerization interface [polypeptide binding]; other site
637905009300	DPS ferroxidase diiron center [ion binding]; other site
637905009301	ion pore; other site
637905009302	potential frameshift: common BLAST hit: gi|212636668|ref|YP_002313193.1| Hydrolase (secreted protein)
637905009303	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
637905009304	active site
637905009305	catalytic residues [active]
637905009306	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
637905009307	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
637905009308	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
637905009309	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
637905009310	Clp amino terminal domain; Region: Clp_N; pfam02861
637905009311	Clp amino terminal domain; Region: Clp_N; pfam02861
637905009312	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905009313	Walker A motif; other site
637905009314	ATP binding site [chemical binding]; other site
637905009315	Walker B motif; other site
637905009316	arginine finger; other site
637905009317	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905009318	Walker A motif; other site
637905009319	ATP binding site [chemical binding]; other site
637905009320	Walker B motif; other site
637905009321	arginine finger; other site
637905009322	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
637905009323	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
637905009324	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
637905009325	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
637905009326	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
637905009327	RNA binding surface [nucleotide binding]; other site
637905009328	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
637905009329	active site
637905009330	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
637905009331	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
637905009332	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905009333	dimerization interface [polypeptide binding]; other site
637905009334	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905009335	dimer interface [polypeptide binding]; other site
637905009336	putative CheW interface [polypeptide binding]; other site
637905009337	ornithine cyclodeaminase; Validated; Region: PRK06141
637905009338	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
637905009339	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
637905009340	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
637905009341	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
637905009342	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
637905009343	RNA binding surface [nucleotide binding]; other site
637905009344	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
637905009345	active site
637905009346	uracil binding [chemical binding]; other site
637905009347	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
637905009348	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
637905009349	active site
637905009350	Zn binding site [ion binding]; other site
637905009351	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
637905009352	synthetase active site [active]
637905009353	NTP binding site [chemical binding]; other site
637905009354	metal binding site [ion binding]; metal-binding site
637905009355	Predicted transcriptional regulator [Transcription]; Region: COG2944
637905009356	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
637905009357	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
637905009358	putative C-terminal domain interface [polypeptide binding]; other site
637905009359	putative GSH binding site (G-site) [chemical binding]; other site
637905009360	putative dimer interface [polypeptide binding]; other site
637905009361	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
637905009362	dimer interface [polypeptide binding]; other site
637905009363	N-terminal domain interface [polypeptide binding]; other site
637905009364	substrate binding pocket (H-site) [chemical binding]; other site
637905009365	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
637905009366	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905009367	N-terminal plug; other site
637905009368	ligand-binding site [chemical binding]; other site
637905009369	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
637905009370	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905009371	active site
637905009372	phosphorylation site [posttranslational modification]
637905009373	intermolecular recognition site; other site
637905009374	dimerization interface [polypeptide binding]; other site
637905009375	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
637905009376	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905009377	ATP binding site [chemical binding]; other site
637905009378	Mg2+ binding site [ion binding]; other site
637905009379	G-X-G motif; other site
637905009380	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
637905009381	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
637905009382	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
637905009383	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
637905009384	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
637905009385	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
637905009386	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
637905009387	Beta-lactamase; Region: Beta-lactamase; pfam00144
637905009388	Beta-lactamase; Region: Beta-lactamase; pfam00144
637905009389	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
637905009390	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
637905009391	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
637905009392	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
637905009393	malate dehydrogenase; Provisional; Region: PRK13529
637905009394	Malic enzyme, N-terminal domain; Region: malic; pfam00390
637905009395	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
637905009396	NAD(P) binding site [chemical binding]; other site
637905009397	Protein of unknown function (DUF3069); Region: DUF3069; pfam11269
637905009398	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
637905009399	active site
637905009400	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
637905009401	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
637905009402	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
637905009403	active site
637905009404	purine riboside binding site [chemical binding]; other site
637905009405	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
637905009406	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
637905009407	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905009408	dimer interface [polypeptide binding]; other site
637905009409	putative CheW interface [polypeptide binding]; other site
637905009410	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
637905009411	epoxyqueuosine reductase; Region: TIGR00276
637905009412	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
637905009413	Dodecin; Region: Dodecin; pfam07311
637905009414	Autoinducer binding domain; Region: Autoind_bind; pfam03472
637905009415	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
637905009416	DNA binding residues [nucleotide binding]
637905009417	dimerization interface [polypeptide binding]; other site
637905009418	Autoinducer synthetase; Region: Autoind_synth; cl17404
637905009419	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
637905009420	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
637905009421	catalytic residues [active]
637905009422	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
637905009423	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
637905009424	catalytic residues [active]
637905009425	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
637905009426	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
637905009427	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
637905009428	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
637905009429	DsbD alpha interface [polypeptide binding]; other site
637905009430	catalytic residues [active]
637905009431	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
637905009432	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
637905009433	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
637905009434	active site
637905009435	FMN binding site [chemical binding]; other site
637905009436	substrate binding site [chemical binding]; other site
637905009437	3Fe-4S cluster binding site [ion binding]; other site
637905009438	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
637905009439	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
637905009440	THF binding site; other site
637905009441	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
637905009442	substrate binding site [chemical binding]; other site
637905009443	THF binding site; other site
637905009444	zinc-binding site [ion binding]; other site
637905009445	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905009446	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905009447	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
637905009448	putative dimerization interface [polypeptide binding]; other site
637905009449	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
637905009450	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
637905009451	active site
637905009452	catalytic triad [active]
637905009453	oxyanion hole [active]
637905009454	switch loop; other site
637905009455	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
637905009456	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905009457	N-terminal plug; other site
637905009458	ligand-binding site [chemical binding]; other site
637905009459	Penicillinase repressor; Region: Pencillinase_R; pfam03965
637905009460	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
637905009461	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
637905009462	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
637905009463	Protein of unknown function (DUF805); Region: DUF805; pfam05656
637905009464	azurin; Region: azurin; TIGR02695
637905009465	short chain dehydrogenase; Validated; Region: PRK08324
637905009466	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
637905009467	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
637905009468	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
637905009469	putative N- and C-terminal domain interface [polypeptide binding]; other site
637905009470	putative active site [active]
637905009471	putative MgATP binding site [chemical binding]; other site
637905009472	catalytic site [active]
637905009473	metal binding site [ion binding]; metal-binding site
637905009474	putative carbohydrate binding site [chemical binding]; other site
637905009475	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
637905009476	Cupin domain; Region: Cupin_2; pfam07883
637905009477	Predicted flavoprotein [General function prediction only]; Region: COG0431
637905009478	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
637905009479	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905009480	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
637905009481	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905009482	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905009483	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
637905009484	putative effector binding pocket; other site
637905009485	dimerization interface [polypeptide binding]; other site
637905009486	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
637905009487	active site
637905009488	substrate binding pocket [chemical binding]; other site
637905009489	dimer interface [polypeptide binding]; other site
637905009490	Predicted permease; Region: DUF318; cl17795
637905009491	Predicted permease; Region: DUF318; cl17795
637905009492	Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily; Region: eu-GS; cl00170
637905009493	glutathione (GSH) binding pocket [chemical binding]; other site
637905009494	active site residues [active]
637905009495	ATP binding pocket [chemical binding]; other site
637905009496	magnesium binding site [ion binding]; other site
637905009497	glycine rich loop; other site
637905009498	alanine rich loop; other site
637905009499	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
637905009500	dimerization interface [polypeptide binding]; other site
637905009501	putative DNA binding site [nucleotide binding]; other site
637905009502	putative Zn2+ binding site [ion binding]; other site
637905009503	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
637905009504	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
637905009505	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
637905009506	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
637905009507	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
637905009508	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
637905009509	active site
637905009510	Zn binding site [ion binding]; other site
637905009511	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
637905009512	Carbon starvation protein CstA; Region: CstA; pfam02554
637905009513	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
637905009514	Peptidase family M48; Region: Peptidase_M48; cl12018
637905009515	CHASE2 domain; Region: CHASE2; pfam05226
637905009516	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
637905009517	cyclase homology domain; Region: CHD; cd07302
637905009518	nucleotidyl binding site; other site
637905009519	metal binding site [ion binding]; metal-binding site
637905009520	dimer interface [polypeptide binding]; other site
637905009521	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
637905009522	GAF domain; Region: GAF_2; pfam13185
637905009523	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
637905009524	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
637905009525	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
637905009526	putative C-terminal domain interface [polypeptide binding]; other site
637905009527	putative GSH binding site (G-site) [chemical binding]; other site
637905009528	putative dimer interface [polypeptide binding]; other site
637905009529	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
637905009530	putative N-terminal domain interface [polypeptide binding]; other site
637905009531	putative dimer interface [polypeptide binding]; other site
637905009532	putative substrate binding pocket (H-site) [chemical binding]; other site
637905009533	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
637905009534	Predicted membrane protein [Function unknown]; Region: COG3235
637905009535	Predicted membrane protein [Function unknown]; Region: COG3235
637905009536	Predicted membrane protein [Function unknown]; Region: COG3235
637905009537	Predicted membrane protein [Function unknown]; Region: COG3235
637905009538	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
637905009539	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
637905009540	dimerization interface [polypeptide binding]; other site
637905009541	substrate binding site [chemical binding]; other site
637905009542	active site
637905009543	calcium binding site [ion binding]; other site
637905009544	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
637905009545	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
637905009546	inhibitor-cofactor binding pocket; inhibition site
637905009547	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905009548	catalytic residue [active]
637905009549	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
637905009550	DNA-binding site [nucleotide binding]; DNA binding site
637905009551	RNA-binding motif; other site
637905009552	nitrite reductase subunit NirD; Provisional; Region: PRK14989
637905009553	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
637905009554	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
637905009555	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
637905009556	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
637905009557	nitrite transporter NirC; Provisional; Region: PRK11562
637905009558	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
637905009559	active site
637905009560	SAM binding site [chemical binding]; other site
637905009561	homodimer interface [polypeptide binding]; other site
637905009562	Ribosome recycling factor; Region: RRF_GI; pfam12614
637905009563	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
637905009564	FG-GAP repeat; Region: FG-GAP_2; pfam14312
637905009565	FG-GAP repeat; Region: FG-GAP_2; pfam14312
637905009566	FG-GAP repeat; Region: FG-GAP_2; pfam14312
637905009567	FG-GAP repeat; Region: FG-GAP_2; pfam14312
637905009568	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
637905009569	catalytic motif [active]
637905009570	Zn binding site [ion binding]; other site
637905009571	glycine dehydrogenase; Provisional; Region: PRK05367
637905009572	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
637905009573	tetramer interface [polypeptide binding]; other site
637905009574	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905009575	catalytic residue [active]
637905009576	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
637905009577	tetramer interface [polypeptide binding]; other site
637905009578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905009579	catalytic residue [active]
637905009580	glycine cleavage system protein H; Provisional; Region: PRK13380
637905009581	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
637905009582	lipoyl attachment site [posttranslational modification]; other site
637905009583	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
637905009584	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
637905009585	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
637905009586	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
637905009587	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
637905009588	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
637905009589	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
637905009590	Cell division protein ZapA; Region: ZapA; cl01146
637905009591	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
637905009592	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
637905009593	Uncharacterized lipoprotein NlpE involved in copper resistance [Cell envelope biogenesis, outer membrane / Inorganic ion transport and metabolism]; Region: CutF; COG3015
637905009594	NlpE N-terminal domain; Region: NlpE; pfam04170
637905009595	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
637905009596	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
637905009597	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
637905009598	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
637905009599	ligand binding site [chemical binding]; other site
637905009600	active site
637905009601	UGI interface [polypeptide binding]; other site
637905009602	catalytic site [active]
637905009603	Protein of unknown function (DUF3144); Region: DUF3144; pfam11342
637905009604	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
637905009605	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
637905009606	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905009607	N-terminal plug; other site
637905009608	ligand-binding site [chemical binding]; other site
637905009609	PAS domain S-box; Region: sensory_box; TIGR00229
637905009610	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
637905009611	putative active site [active]
637905009612	heme pocket [chemical binding]; other site
637905009613	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
637905009614	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905009615	Walker A motif; other site
637905009616	ATP binding site [chemical binding]; other site
637905009617	Walker B motif; other site
637905009618	arginine finger; other site
637905009619	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
637905009620	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
637905009621	4Fe-4S binding domain; Region: Fer4_5; pfam12801
637905009622	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
637905009623	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
637905009624	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677
637905009625	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
637905009626	acyl-activating enzyme (AAE) consensus motif; other site
637905009627	putative AMP binding site [chemical binding]; other site
637905009628	putative active site [active]
637905009629	putative CoA binding site [chemical binding]; other site
637905009630	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
637905009631	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
637905009632	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
637905009633	catalytic residues [active]
637905009634	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
637905009635	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
637905009636	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637905009637	Walker A/P-loop; other site
637905009638	ATP binding site [chemical binding]; other site
637905009639	Q-loop/lid; other site
637905009640	ABC transporter signature motif; other site
637905009641	Walker B; other site
637905009642	D-loop; other site
637905009643	H-loop/switch region; other site
637905009644	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
637905009645	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
637905009646	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
637905009647	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
637905009648	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905009649	N-terminal plug; other site
637905009650	ligand-binding site [chemical binding]; other site
637905009651	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
637905009652	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
637905009653	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
637905009654	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
637905009655	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
637905009656	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
637905009657	intersubunit interface [polypeptide binding]; other site
637905009658	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
637905009659	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
637905009660	ABC-ATPase subunit  interface; other site
637905009661	dimer interface [polypeptide binding]; other site
637905009662	putative PBP binding regions; other site
637905009663	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
637905009664	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
637905009665	Walker A/P-loop; other site
637905009666	ATP binding site [chemical binding]; other site
637905009667	Q-loop/lid; other site
637905009668	ABC transporter signature motif; other site
637905009669	Walker B; other site
637905009670	D-loop; other site
637905009671	H-loop/switch region; other site
637905009672	coproporphyrinogen III oxidase; Provisional; Region: PRK09058
637905009673	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637905009674	FeS/SAM binding site; other site
637905009675	Protein of unknown function (DUF2956); Region: DUF2956; pfam11169
637905009676	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
637905009677	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
637905009678	active site
637905009679	trimer interface [polypeptide binding]; other site
637905009680	allosteric site; other site
637905009681	active site lid [active]
637905009682	hexamer (dimer of trimers) interface [polypeptide binding]; other site
637905009683	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
637905009684	pseudouridine synthase; Region: TIGR00093
637905009685	active site
637905009686	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
637905009687	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905009688	N-terminal plug; other site
637905009689	ligand-binding site [chemical binding]; other site
637905009690	ammonium transporter; Region: amt; TIGR00836
637905009691	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
637905009692	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
637905009693	dimer interface [polypeptide binding]; other site
637905009694	phosphorylation site [posttranslational modification]
637905009695	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905009696	ATP binding site [chemical binding]; other site
637905009697	Mg2+ binding site [ion binding]; other site
637905009698	G-X-G motif; other site
637905009699	SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839
637905009700	active site
637905009701	catalytic triad [active]
637905009702	oxyanion hole [active]
637905009703	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
637905009704	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
637905009705	dimer interface [polypeptide binding]; other site
637905009706	putative anticodon binding site; other site
637905009707	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
637905009708	motif 1; other site
637905009709	active site
637905009710	motif 2; other site
637905009711	motif 3; other site
637905009712	peptide chain release factor 2; Validated; Region: prfB; PRK00578
637905009713	This domain is found in peptide chain release factors; Region: PCRF; smart00937
637905009714	RF-1 domain; Region: RF-1; pfam00472
637905009715	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
637905009716	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
637905009717	Ion channel; Region: Ion_trans_2; pfam07885
637905009718	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
637905009719	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
637905009720	MarR family; Region: MarR; pfam01047
637905009721	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
637905009722	ligand binding site [chemical binding]; other site
637905009723	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905009724	metal binding site [ion binding]; metal-binding site
637905009725	active site
637905009726	I-site; other site
637905009727	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
637905009728	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
637905009729	catalytic residue [active]
637905009730	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
637905009731	catalytic residues [active]
637905009732	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
637905009733	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
637905009734	peroxiredoxin; Region: AhpC; TIGR03137
637905009735	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
637905009736	dimer interface [polypeptide binding]; other site
637905009737	decamer (pentamer of dimers) interface [polypeptide binding]; other site
637905009738	catalytic triad [active]
637905009739	peroxidatic and resolving cysteines [active]
637905009740	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905009741	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
637905009742	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
637905009743	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
637905009744	putative ligand binding site [chemical binding]; other site
637905009745	putative NAD binding site [chemical binding]; other site
637905009746	catalytic site [active]
637905009747	Methyltransferase domain; Region: Methyltransf_31; pfam13847
637905009748	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905009749	S-adenosylmethionine binding site [chemical binding]; other site
637905009750	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
637905009751	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637905009752	DNA binding site [nucleotide binding]
637905009753	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
637905009754	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
637905009755	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
637905009756	active site
637905009757	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
637905009758	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
637905009759	putative DNA binding site [nucleotide binding]; other site
637905009760	putative Zn2+ binding site [ion binding]; other site
637905009761	AsnC family; Region: AsnC_trans_reg; pfam01037
637905009762	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
637905009763	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
637905009764	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
637905009765	active site
637905009766	catalytic residues [active]
637905009767	PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818
637905009768	PA/protease or protease-like domain interface [polypeptide binding]; other site
637905009769	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
637905009770	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
637905009771	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
637905009772	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
637905009773	GlyGly-CTERM domain; Region: GlyGly_CTERM; TIGR03501
637905009774	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
637905009775	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
637905009776	active site
637905009777	Zn binding site [ion binding]; other site
637905009778	aspartate kinase III; Validated; Region: PRK09084
637905009779	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
637905009780	nucleotide binding site [chemical binding]; other site
637905009781	substrate binding site [chemical binding]; other site
637905009782	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
637905009783	dimer interface [polypeptide binding]; other site
637905009784	allosteric regulatory binding pocket; other site
637905009785	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
637905009786	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
637905009787	two-component response regulator; Provisional; Region: PRK11173
637905009788	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905009789	active site
637905009790	phosphorylation site [posttranslational modification]
637905009791	intermolecular recognition site; other site
637905009792	dimerization interface [polypeptide binding]; other site
637905009793	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637905009794	DNA binding site [nucleotide binding]
637905009795	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
637905009796	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
637905009797	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
637905009798	fructose-1,6-bisphosphatase family protein; Region: PLN02628
637905009799	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
637905009800	AMP binding site [chemical binding]; other site
637905009801	metal binding site [ion binding]; metal-binding site
637905009802	active site
637905009803	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
637905009804	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
637905009805	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
637905009806	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
637905009807	amino acid carrier protein; Region: agcS; TIGR00835
637905009808	Protein of unknown function (DUF3581); Region: DUF3581; pfam12119
637905009809	potential frameshift: common BLAST hit: gi|157377020|ref|YP_001475620.1| TonB-dependent receptor
637905009810	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905009811	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905009812	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
637905009813	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
637905009814	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905009815	FMN-binding domain; Region: FMN_bind; pfam04205
637905009816	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
637905009817	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
637905009818	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
637905009819	trimer interface [polypeptide binding]; other site
637905009820	eyelet of channel; other site
637905009821	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
637905009822	Transglycosylase; Region: Transgly; pfam00912
637905009823	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
637905009824	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
637905009825	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637905009826	ATP binding site [chemical binding]; other site
637905009827	putative Mg++ binding site [ion binding]; other site
637905009828	helicase superfamily c-terminal domain; Region: HELICc; smart00490
637905009829	nucleotide binding region [chemical binding]; other site
637905009830	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
637905009831	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
637905009832	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
637905009833	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
637905009834	aminopeptidase B; Provisional; Region: PRK05015
637905009835	Peptidase; Region: DUF3663; pfam12404
637905009836	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
637905009837	interface (dimer of trimers) [polypeptide binding]; other site
637905009838	Substrate-binding/catalytic site; other site
637905009839	Zn-binding sites [ion binding]; other site
637905009840	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
637905009841	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
637905009842	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
637905009843	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
637905009844	active site
637905009845	HIGH motif; other site
637905009846	nucleotide binding site [chemical binding]; other site
637905009847	active site
637905009848	KMSKS motif; other site
637905009849	poly(A) polymerase; Region: pcnB; TIGR01942
637905009850	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
637905009851	active site
637905009852	NTP binding site [chemical binding]; other site
637905009853	metal binding triad [ion binding]; metal-binding site
637905009854	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
637905009855	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
637905009856	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
637905009857	catalytic center binding site [active]
637905009858	ATP binding site [chemical binding]; other site
637905009859	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
637905009860	oligomerization interface [polypeptide binding]; other site
637905009861	active site
637905009862	metal binding site [ion binding]; metal-binding site
637905009863	Pantoate-beta-alanine ligase; Region: PanC; cd00560
637905009864	pantoate--beta-alanine ligase; Region: panC; TIGR00018
637905009865	active site
637905009866	ATP-binding site [chemical binding]; other site
637905009867	pantoate-binding site; other site
637905009868	HXXH motif; other site
637905009869	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
637905009870	protein structure with unknown function; Region: DUF4144; pfam13642
637905009871	inner membrane transport permease; Provisional; Region: PRK15066
637905009872	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
637905009873	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
637905009874	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637905009875	Walker A/P-loop; other site
637905009876	ATP binding site [chemical binding]; other site
637905009877	Q-loop/lid; other site
637905009878	ABC transporter signature motif; other site
637905009879	Walker B; other site
637905009880	D-loop; other site
637905009881	H-loop/switch region; other site
637905009882	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
637905009883	active site
637905009884	aromatic acid decarboxylase; Validated; Region: PRK05920
637905009885	Flavoprotein; Region: Flavoprotein; pfam02441
637905009886	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
637905009887	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
637905009888	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
637905009889	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
637905009890	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
637905009891	Uncharacterized conserved protein [Function unknown]; Region: COG2968
637905009892	oxidative stress defense protein; Provisional; Region: PRK11087
637905009893	FOG: WD40 repeat [General function prediction only]; Region: COG2319
637905009894	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
637905009895	structural tetrad; other site
637905009896	potential frameshift: common BLAST hit: gi|209809766|ref|YP_002265305.1| tryptophanyl-tRNA synthetase II
637905009897	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
637905009898	active site
637905009899	KMSKS motif; other site
637905009900	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
637905009901	active site
637905009902	HIGH motif; other site
637905009903	nucleotide binding site [chemical binding]; other site
637905009904	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
637905009905	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
637905009906	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
637905009907	succinic semialdehyde dehydrogenase; Region: PLN02278
637905009908	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
637905009909	tetramerization interface [polypeptide binding]; other site
637905009910	NAD(P) binding site [chemical binding]; other site
637905009911	catalytic residues [active]
637905009912	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905009913	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905009914	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
637905009915	dimerization interface [polypeptide binding]; other site
637905009916	Uncharacterized conserved protein [Function unknown]; Region: COG1359
637905009917	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
637905009918	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
637905009919	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
637905009920	substrate binding pocket [chemical binding]; other site
637905009921	membrane-bound complex binding site; other site
637905009922	hinge residues; other site
637905009923	Protein of unknown function (DUF3087); Region: DUF3087; pfam11286
637905009924	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
637905009925	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
637905009926	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
637905009927	RNA binding surface [nucleotide binding]; other site
637905009928	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
637905009929	probable active site [active]
637905009930	Peptidase S46; Region: Peptidase_S46; pfam10459
637905009931	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
637905009932	Predicted membrane protein [Function unknown]; Region: COG2119
637905009933	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
637905009934	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
637905009935	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
637905009936	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
637905009937	tetramer interface [polypeptide binding]; other site
637905009938	heme binding pocket [chemical binding]; other site
637905009939	NADPH binding site [chemical binding]; other site
637905009940	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
637905009941	CoenzymeA binding site [chemical binding]; other site
637905009942	subunit interaction site [polypeptide binding]; other site
637905009943	PHB binding site; other site
637905009944	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
637905009945	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
637905009946	generic binding surface II; other site
637905009947	generic binding surface I; other site
637905009948	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
637905009949	putative catalytic site [active]
637905009950	putative metal binding site [ion binding]; other site
637905009951	putative phosphate binding site [ion binding]; other site
637905009952	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
637905009953	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
637905009954	DNA binding residues [nucleotide binding]
637905009955	dimerization interface [polypeptide binding]; other site
637905009956	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
637905009957	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
637905009958	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
637905009959	ligand binding site [chemical binding]; other site
637905009960	NAD binding site [chemical binding]; other site
637905009961	tetramer interface [polypeptide binding]; other site
637905009962	catalytic site [active]
637905009963	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
637905009964	L-serine binding site [chemical binding]; other site
637905009965	ACT domain interface; other site
637905009966	putative global regulator; Reviewed; Region: PRK09559
637905009967	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
637905009968	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
637905009969	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
637905009970	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
637905009971	apolar tunnel; other site
637905009972	heme binding site [chemical binding]; other site
637905009973	dimerization interface [polypeptide binding]; other site
637905009974	FAD dependent oxidoreductase; Region: DAO; pfam01266
637905009975	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
637905009976	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
637905009977	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
637905009978	Walker A/P-loop; other site
637905009979	ATP binding site [chemical binding]; other site
637905009980	Q-loop/lid; other site
637905009981	ABC transporter signature motif; other site
637905009982	Walker B; other site
637905009983	D-loop; other site
637905009984	H-loop/switch region; other site
637905009985	FtsX-like permease family; Region: FtsX; pfam02687
637905009986	FtsX-like permease family; Region: FtsX; pfam02687
637905009987	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
637905009988	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
637905009989	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
637905009990	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
637905009991	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
637905009992	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
637905009993	PAS domain; Region: PAS_9; pfam13426
637905009994	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905009995	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905009996	metal binding site [ion binding]; metal-binding site
637905009997	active site
637905009998	I-site; other site
637905009999	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
637905010000	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
637905010001	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
637905010002	ATP-grasp domain; Region: ATP-grasp_4; cl17255
637905010003	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
637905010004	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
637905010005	carboxyltransferase (CT) interaction site; other site
637905010006	biotinylation site [posttranslational modification]; other site
637905010007	LysR family transcriptional regulator; Provisional; Region: PRK14997
637905010008	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905010009	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
637905010010	putative effector binding pocket; other site
637905010011	dimerization interface [polypeptide binding]; other site
637905010012	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
637905010013	putative substrate binding pocket [chemical binding]; other site
637905010014	AC domain interface; other site
637905010015	catalytic triad [active]
637905010016	AB domain interface; other site
637905010017	interchain disulfide; other site
637905010018	hypothetical protein; Provisional; Region: PRK04860
637905010019	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
637905010020	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
637905010021	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
637905010022	RNA methyltransferase, RsmE family; Region: TIGR00046
637905010023	glutathione synthetase; Provisional; Region: PRK05246
637905010024	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
637905010025	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
637905010026	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
637905010027	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
637905010028	active site
637905010029	dimer interface [polypeptide binding]; other site
637905010030	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905010031	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905010032	metal binding site [ion binding]; metal-binding site
637905010033	active site
637905010034	I-site; other site
637905010035	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
637905010036	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
637905010037	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
637905010038	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905010039	S-adenosylmethionine binding site [chemical binding]; other site
637905010040	Protein of unknown function (DUF342); Region: DUF342; pfam03961
637905010041	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829
637905010042	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
637905010043	Peptidase family M50; Region: Peptidase_M50; pfam02163
637905010044	active site
637905010045	putative substrate binding region [chemical binding]; other site
637905010046	Protein of unknown function (DUF3149); Region: DUF3149; pfam11346
637905010047	Superinfection exclusion protein B; Region: SieB; pfam14163
637905010048	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
637905010049	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
637905010050	dimer interface [polypeptide binding]; other site
637905010051	phosphorylation site [posttranslational modification]
637905010052	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905010053	ATP binding site [chemical binding]; other site
637905010054	Mg2+ binding site [ion binding]; other site
637905010055	G-X-G motif; other site
637905010056	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
637905010057	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
637905010058	putative ATP binding site [chemical binding]; other site
637905010059	putative substrate interface [chemical binding]; other site
637905010060	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
637905010061	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
637905010062	eyelet of channel; other site
637905010063	trimer interface [polypeptide binding]; other site
637905010064	thiopurine S-methyltransferase; Reviewed; Region: PRK13255
637905010065	Catalytic domain of Protein Kinases; Region: PKc; cd00180
637905010066	active site
637905010067	ATP binding site [chemical binding]; other site
637905010068	substrate binding site [chemical binding]; other site
637905010069	activation loop (A-loop); other site
637905010070	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
637905010071	CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091
637905010072	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
637905010073	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
637905010074	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
637905010075	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
637905010076	DsbD alpha interface [polypeptide binding]; other site
637905010077	catalytic residues [active]
637905010078	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
637905010079	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
637905010080	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
637905010081	TrkA-N domain; Region: TrkA_N; pfam02254
637905010082	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
637905010083	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
637905010084	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
637905010085	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
637905010086	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
637905010087	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
637905010088	putative transporter; Provisional; Region: PRK10484
637905010089	uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328
637905010090	Na binding site [ion binding]; other site
637905010091	galactokinase; Provisional; Region: PRK05101
637905010092	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
637905010093	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
637905010094	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
637905010095	active site
637905010096	catalytic residues [active]
637905010097	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
637905010098	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
637905010099	NAD(P) binding site [chemical binding]; other site
637905010100	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
637905010101	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
637905010102	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
637905010103	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
637905010104	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
637905010105	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
637905010106	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
637905010107	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
637905010108	catalytic triad [active]
637905010109	putative active site [active]
637905010110	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
637905010111	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
637905010112	major curlin subunit; Provisional; Region: csgA; PRK10051
637905010113	Curlin associated repeat; Region: Curlin_rpt; pfam07012
637905010114	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
637905010115	Curlin associated repeat; Region: Curlin_rpt; pfam07012
637905010116	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
637905010117	Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082
637905010118	Curli assembly protein CsgE; Region: CsgE; pfam10627
637905010119	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
637905010120	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
637905010121	dimer interface [polypeptide binding]; other site
637905010122	ssDNA binding site [nucleotide binding]; other site
637905010123	tetramer (dimer of dimers) interface [polypeptide binding]; other site
637905010124	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905010125	Major Facilitator Superfamily; Region: MFS_1; pfam07690
637905010126	putative substrate translocation pore; other site
637905010127	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
637905010128	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
637905010129	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
637905010130	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
637905010131	M28 Zn-Peptidases; Region: M28_like_2; cd05662
637905010132	Peptidase family M28; Region: Peptidase_M28; pfam04389
637905010133	metal binding site [ion binding]; metal-binding site
637905010134	helicase 45; Provisional; Region: PTZ00424
637905010135	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
637905010136	ATP binding site [chemical binding]; other site
637905010137	Mg++ binding site [ion binding]; other site
637905010138	motif III; other site
637905010139	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905010140	nucleotide binding region [chemical binding]; other site
637905010141	ATP-binding site [chemical binding]; other site
637905010142	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
637905010143	Predicted dehydrogenase [General function prediction only]; Region: COG0579
637905010144	hydroxyglutarate oxidase; Provisional; Region: PRK11728
637905010145	EamA-like transporter family; Region: EamA; cl17759
637905010146	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
637905010147	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
637905010148	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
637905010149	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
637905010150	FAD binding site [chemical binding]; other site
637905010151	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
637905010152	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
637905010153	nucleotide binding site [chemical binding]; other site
637905010154	substrate binding site [chemical binding]; other site
637905010155	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
637905010156	O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080
637905010157	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
637905010158	homodimer interface [polypeptide binding]; other site
637905010159	substrate-cofactor binding pocket; other site
637905010160	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905010161	catalytic residue [active]
637905010162	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
637905010163	dimerization interface [polypeptide binding]; other site
637905010164	DNA binding site [nucleotide binding]
637905010165	corepressor binding sites; other site
637905010166	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
637905010167	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
637905010168	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905010169	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905010170	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
637905010171	putative effector binding pocket; other site
637905010172	dimerization interface [polypeptide binding]; other site
637905010173	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
637905010174	classical (c) SDRs; Region: SDR_c; cd05233
637905010175	NAD(P) binding site [chemical binding]; other site
637905010176	active site
637905010177	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
637905010178	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
637905010179	FMN binding site [chemical binding]; other site
637905010180	active site
637905010181	substrate binding site [chemical binding]; other site
637905010182	catalytic residue [active]
637905010183	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905010184	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905010185	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
637905010186	putative effector binding pocket; other site
637905010187	dimerization interface [polypeptide binding]; other site
637905010188	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905010189	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
637905010190	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
637905010191	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905010192	active site
637905010193	phosphorylation site [posttranslational modification]
637905010194	intermolecular recognition site; other site
637905010195	dimerization interface [polypeptide binding]; other site
637905010196	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
637905010197	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
637905010198	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905010199	ATP binding site [chemical binding]; other site
637905010200	Mg2+ binding site [ion binding]; other site
637905010201	G-X-G motif; other site
637905010202	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
637905010203	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
637905010204	NADP binding site [chemical binding]; other site
637905010205	active site
637905010206	putative substrate binding site [chemical binding]; other site
637905010207	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
637905010208	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
637905010209	metal binding site [ion binding]; metal-binding site
637905010210	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
637905010211	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
637905010212	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
637905010213	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
637905010214	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
637905010215	probable active site [active]
637905010216	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
637905010217	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
637905010218	Domain of unknown function (DUF386); Region: DUF386; cl01047
637905010219	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905010220	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
637905010221	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
637905010222	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
637905010223	catalytic residue [active]
637905010224	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
637905010225	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
637905010226	active site residue [active]
637905010227	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
637905010228	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
637905010229	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
637905010230	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
637905010231	active site
637905010232	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
637905010233	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
637905010234	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637905010235	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905010236	Outer membrane efflux protein; Region: OEP; pfam02321
637905010237	Protein of unknown function (DUF3012); Region: DUF3012; pfam11216
637905010238	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
637905010239	hypothetical protein; Provisional; Region: PRK09256
637905010240	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
637905010241	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
637905010242	Dehydroquinase class II; Region: DHquinase_II; pfam01220
637905010243	active site
637905010244	trimer interface [polypeptide binding]; other site
637905010245	dimer interface [polypeptide binding]; other site
637905010246	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
637905010247	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
637905010248	carboxyltransferase (CT) interaction site; other site
637905010249	biotinylation site [posttranslational modification]; other site
637905010250	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
637905010251	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
637905010252	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
637905010253	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
637905010254	ATP-grasp domain; Region: ATP-grasp_4; cl17255
637905010255	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
637905010256	ATP-grasp domain; Region: ATP-grasp_4; cl17255
637905010257	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
637905010258	Surface antigen; Region: Bac_surface_Ag; pfam01103
637905010259	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
637905010260	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
637905010261	BON domain; Region: BON; pfam04972
637905010262	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
637905010263	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
637905010264	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
637905010265	substrate binding pocket [chemical binding]; other site
637905010266	membrane-bound complex binding site; other site
637905010267	hinge residues; other site
637905010268	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
637905010269	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
637905010270	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
637905010271	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
637905010272	active site
637905010273	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
637905010274	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
637905010275	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
637905010276	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
637905010277	putative active site [active]
637905010278	putative metal binding site [ion binding]; other site
637905010279	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
637905010280	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905010281	S-adenosylmethionine binding site [chemical binding]; other site
637905010282	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
637905010283	SCP-2 sterol transfer family; Region: SCP2; pfam02036
637905010284	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
637905010285	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
637905010286	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
637905010287	sec-independent translocase; Provisional; Region: PRK01770
637905010288	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
637905010289	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
637905010290	active site
637905010291	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
637905010292	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
637905010293	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905010294	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905010295	metal binding site [ion binding]; metal-binding site
637905010296	active site
637905010297	I-site; other site
637905010298	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
637905010299	dimer interface [polypeptide binding]; other site
637905010300	allosteric magnesium binding site [ion binding]; other site
637905010301	active site
637905010302	aspartate-rich active site metal binding site; other site
637905010303	Schiff base residues; other site
637905010304	potential frameshift: common BLAST hit: gi|27367861|ref|NP_763388.1| autotransporter adhesin
637905010305	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
637905010306	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
637905010307	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
637905010308	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
637905010309	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
637905010310	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
637905010311	putative active site [active]
637905010312	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
637905010313	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
637905010314	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637905010315	Walker A/P-loop; other site
637905010316	ATP binding site [chemical binding]; other site
637905010317	Q-loop/lid; other site
637905010318	ABC transporter signature motif; other site
637905010319	Walker B; other site
637905010320	D-loop; other site
637905010321	H-loop/switch region; other site
637905010322	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
637905010323	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
637905010324	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905010325	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
637905010326	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
637905010327	ligand binding site [chemical binding]; other site
637905010328	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
637905010329	catalytic residues [active]
637905010330	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
637905010331	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905010332	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905010333	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
637905010334	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905010335	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
637905010336	exopolyphosphatase; Region: exo_poly_only; TIGR03706
637905010337	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
637905010338	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
637905010339	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
637905010340	ATP binding site [chemical binding]; other site
637905010341	Mg++ binding site [ion binding]; other site
637905010342	motif III; other site
637905010343	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905010344	nucleotide binding region [chemical binding]; other site
637905010345	ATP-binding site [chemical binding]; other site
637905010346	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
637905010347	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
637905010348	catalytic residues [active]
637905010349	transcription termination factor Rho; Provisional; Region: rho; PRK09376
637905010350	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
637905010351	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
637905010352	RNA binding site [nucleotide binding]; other site
637905010353	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
637905010354	multimer interface [polypeptide binding]; other site
637905010355	Walker A motif; other site
637905010356	ATP binding site [chemical binding]; other site
637905010357	Walker B motif; other site
637905010358	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
637905010359	DNA methylase; Region: N6_N4_Mtase; cl17433
637905010360	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905010361	S-adenosylmethionine binding site [chemical binding]; other site
637905010362	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
637905010363	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
637905010364	FMN binding site [chemical binding]; other site
637905010365	active site
637905010366	catalytic residues [active]
637905010367	substrate binding site [chemical binding]; other site
637905010368	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
637905010369	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
637905010370	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
637905010371	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
637905010372	Hemerythrin-like domain; Region: Hr-like; cd12108
637905010373	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
637905010374	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
637905010375	motif II; other site
637905010376	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
637905010377	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
637905010378	active site
637905010379	DNA binding site [nucleotide binding]
637905010380	Int/Topo IB signature motif; other site
637905010381	Protein of unknown function, DUF484; Region: DUF484; cl17449
637905010382	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
637905010383	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
637905010384	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
637905010385	diaminopimelate decarboxylase; Region: lysA; TIGR01048
637905010386	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
637905010387	active site
637905010388	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
637905010389	substrate binding site [chemical binding]; other site
637905010390	catalytic residues [active]
637905010391	dimer interface [polypeptide binding]; other site
637905010392	Frataxin-like domain; Region: Frataxin_Cyay; pfam01491
637905010393	putative iron binding site [ion binding]; other site
637905010394	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
637905010395	adenylate cyclase; Provisional; Region: cyaA; PRK09450
637905010396	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
637905010397	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
637905010398	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
637905010399	domain interfaces; other site
637905010400	active site
637905010401	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
637905010402	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
637905010403	active site
637905010404	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
637905010405	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
637905010406	HemY protein N-terminus; Region: HemY_N; pfam07219
637905010407	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
637905010408	binding surface
637905010409	TPR motif; other site
637905010410	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010411	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010412	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010413	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010414	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010415	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010416	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010417	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010418	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010419	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010420	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010421	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010422	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010423	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010424	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010425	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010426	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010427	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
637905010428	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010429	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010430	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010431	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010432	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010433	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010434	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010435	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010436	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010437	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010438	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010439	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010440	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010441	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010442	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010443	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010444	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010445	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010446	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010447	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010448	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010449	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010450	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010451	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010452	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010453	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010454	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010455	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010456	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010457	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010458	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010459	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010460	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010461	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010462	VCBS repeat; Region: VCBS_repeat; TIGR01965
637905010463	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
637905010464	metal ion-dependent adhesion site (MIDAS); other site
637905010465	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
637905010466	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
637905010467	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421
637905010468	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
637905010469	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
637905010470	Walker A/P-loop; other site
637905010471	ATP binding site [chemical binding]; other site
637905010472	Q-loop/lid; other site
637905010473	ABC transporter signature motif; other site
637905010474	Walker B; other site
637905010475	D-loop; other site
637905010476	H-loop/switch region; other site
637905010477	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
637905010478	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637905010479	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905010480	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
637905010481	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
637905010482	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
637905010483	ligand binding site [chemical binding]; other site
637905010484	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
637905010485	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905010486	dimerization interface [polypeptide binding]; other site
637905010487	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905010488	metal binding site [ion binding]; metal-binding site
637905010489	active site
637905010490	I-site; other site
637905010491	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
637905010492	Protein of unknown function (DUF1059); Region: DUF1059; cl02284
637905010493	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
637905010494	GAF domain; Region: GAF; pfam01590
637905010495	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
637905010496	GAF domain; Region: GAF_2; pfam13185
637905010497	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905010498	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905010499	metal binding site [ion binding]; metal-binding site
637905010500	active site
637905010501	I-site; other site
637905010502	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
637905010503	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
637905010504	Part of AAA domain; Region: AAA_19; pfam13245
637905010505	Family description; Region: UvrD_C_2; pfam13538
637905010506	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
637905010507	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
637905010508	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
637905010509	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
637905010510	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905010511	multidrug efflux protein; Reviewed; Region: PRK09579
637905010512	Protein export membrane protein; Region: SecD_SecF; cl14618
637905010513	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
637905010514	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
637905010515	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
637905010516	active site
637905010517	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
637905010518	dimerization interface [polypeptide binding]; other site
637905010519	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
637905010520	putative Zn2+ binding site [ion binding]; other site
637905010521	putative DNA binding site [nucleotide binding]; other site
637905010522	AsnC family; Region: AsnC_trans_reg; pfam01037
637905010523	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
637905010524	Na2 binding site [ion binding]; other site
637905010525	putative substrate binding site 1 [chemical binding]; other site
637905010526	Na binding site 1 [ion binding]; other site
637905010527	putative substrate binding site 2 [chemical binding]; other site
637905010528	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
637905010529	homodimer interface [polypeptide binding]; other site
637905010530	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905010531	catalytic residue [active]
637905010532	threonine dehydratase; Reviewed; Region: PRK09224
637905010533	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
637905010534	tetramer interface [polypeptide binding]; other site
637905010535	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905010536	catalytic residue [active]
637905010537	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
637905010538	putative Ile/Val binding site [chemical binding]; other site
637905010539	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
637905010540	putative Ile/Val binding site [chemical binding]; other site
637905010541	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
637905010542	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
637905010543	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
637905010544	homodimer interface [polypeptide binding]; other site
637905010545	substrate-cofactor binding pocket; other site
637905010546	catalytic residue [active]
637905010547	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
637905010548	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
637905010549	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
637905010550	PYR/PP interface [polypeptide binding]; other site
637905010551	dimer interface [polypeptide binding]; other site
637905010552	TPP binding site [chemical binding]; other site
637905010553	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
637905010554	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
637905010555	TPP-binding site [chemical binding]; other site
637905010556	dimer interface [polypeptide binding]; other site
637905010557	ketol-acid reductoisomerase; Validated; Region: PRK05225
637905010558	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
637905010559	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
637905010560	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
637905010561	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905010562	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
637905010563	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
637905010564	putative dimerization interface [polypeptide binding]; other site
637905010565	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
637905010566	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
637905010567	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
637905010568	active site
637905010569	Zn binding site [ion binding]; other site
637905010570	serine acetyltransferase; Provisional; Region: cysE; PRK11132
637905010571	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
637905010572	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
637905010573	trimer interface [polypeptide binding]; other site
637905010574	active site
637905010575	substrate binding site [chemical binding]; other site
637905010576	CoA binding site [chemical binding]; other site
637905010577	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
637905010578	UbiA prenyltransferase family; Region: UbiA; pfam01040
637905010579	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
637905010580	Part of AAA domain; Region: AAA_19; pfam13245
637905010581	Family description; Region: UvrD_C_2; pfam13538
637905010582	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
637905010583	homotrimer interaction site [polypeptide binding]; other site
637905010584	putative active site [active]
637905010585	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
637905010586	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
637905010587	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
637905010588	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
637905010589	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
637905010590	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
637905010591	uridine phosphorylase; Provisional; Region: PRK11178
637905010592	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
637905010593	Protein of unknown function (DUF465); Region: DUF465; cl01070
637905010594	Conserved TM helix; Region: TM_helix; pfam05552
637905010595	Mechanosensitive ion channel; Region: MS_channel; pfam00924
637905010596	outer membrane protein A; Reviewed; Region: PRK10808
637905010597	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
637905010598	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
637905010599	ligand binding site [chemical binding]; other site
637905010600	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905010601	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905010602	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
637905010603	dimerization interface [polypeptide binding]; other site
637905010604	Transcriptional regulator [Transcription]; Region: LysR; COG0583
637905010605	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905010606	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
637905010607	substrate binding pocket [chemical binding]; other site
637905010608	dimerization interface [polypeptide binding]; other site
637905010609	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
637905010610	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637905010611	FeS/SAM binding site; other site
637905010612	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637905010613	Coenzyme A binding pocket [chemical binding]; other site
637905010614	hypothetical protein; Provisional; Region: PRK12378
637905010615	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
637905010616	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
637905010617	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
637905010618	Predicted permease; Region: DUF318; cl17795
637905010619	Predicted permease; Region: DUF318; cl17795
637905010620	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
637905010621	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
637905010622	DNA binding residues [nucleotide binding]
637905010623	dimer interface [polypeptide binding]; other site
637905010624	metal binding site [ion binding]; metal-binding site
637905010625	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
637905010626	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
637905010627	purine monophosphate binding site [chemical binding]; other site
637905010628	dimer interface [polypeptide binding]; other site
637905010629	putative catalytic residues [active]
637905010630	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
637905010631	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
637905010632	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
637905010633	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
637905010634	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
637905010635	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
637905010636	short chain dehydrogenase; Provisional; Region: PRK06181
637905010637	NAD(P) binding site [chemical binding]; other site
637905010638	active site
637905010639	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
637905010640	PAS domain; Region: PAS_9; pfam13426
637905010641	putative active site [active]
637905010642	heme pocket [chemical binding]; other site
637905010643	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
637905010644	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
637905010645	metal binding site [ion binding]; metal-binding site
637905010646	active site
637905010647	I-site; other site
637905010648	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
637905010649	Spondin_N; Region: Spond_N; pfam06468
637905010650	Spondin_N; Region: Spond_N; pfam06468
637905010651	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
637905010652	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905010653	active site
637905010654	phosphorylation site [posttranslational modification]
637905010655	intermolecular recognition site; other site
637905010656	dimerization interface [polypeptide binding]; other site
637905010657	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637905010658	DNA binding site [nucleotide binding]
637905010659	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
637905010660	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
637905010661	dimer interface [polypeptide binding]; other site
637905010662	phosphorylation site [posttranslational modification]
637905010663	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905010664	ATP binding site [chemical binding]; other site
637905010665	Mg2+ binding site [ion binding]; other site
637905010666	G-X-G motif; other site
637905010667	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
637905010668	substrate binding site [chemical binding]; other site
637905010669	active site
637905010670	anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718
637905010671	Predicted amidohydrolase [General function prediction only]; Region: COG0388
637905010672	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
637905010673	putative active site [active]
637905010674	catalytic triad [active]
637905010675	putative dimer interface [polypeptide binding]; other site
637905010676	Domain of unknown function (DUF3859); Region: DUF3859; pfam12975
637905010677	dUMP phosphatase; Provisional; Region: PRK09449
637905010678	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
637905010679	motif II; other site
637905010680	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
637905010681	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
637905010682	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
637905010683	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
637905010684	Catalytic site [active]
637905010685	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
637905010686	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
637905010687	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
637905010688	catalytic residues [active]
637905010689	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
637905010690	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
637905010691	DNA-binding site [nucleotide binding]; DNA binding site
637905010692	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
637905010693	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905010694	homodimer interface [polypeptide binding]; other site
637905010695	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
637905010696	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
637905010697	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
637905010698	Response regulator receiver domain; Region: Response_reg; pfam00072
637905010699	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905010700	active site
637905010701	phosphorylation site [posttranslational modification]
637905010702	intermolecular recognition site; other site
637905010703	dimerization interface [polypeptide binding]; other site
637905010704	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
637905010705	FMN reductase; Validated; Region: fre; PRK08051
637905010706	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
637905010707	FAD binding pocket [chemical binding]; other site
637905010708	FAD binding motif [chemical binding]; other site
637905010709	phosphate binding motif [ion binding]; other site
637905010710	beta-alpha-beta structure motif; other site
637905010711	NAD binding pocket [chemical binding]; other site
637905010712	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
637905010713	Phosphotransferase enzyme family; Region: APH; pfam01636
637905010714	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
637905010715	active site
637905010716	ATP binding site [chemical binding]; other site
637905010717	substrate binding site [chemical binding]; other site
637905010718	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
637905010719	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
637905010720	inhibitor-cofactor binding pocket; inhibition site
637905010721	pyridoxal 5'-phosphate binding site [chemical binding]; other site
637905010722	catalytic residue [active]
637905010723	Saccharopine Dehydrogenase NAD-binding and catalytic domains; Region: SDH; cd12188
637905010724	active site
637905010725	ligand binding site [chemical binding]; other site
637905010726	homodimer interface [polypeptide binding]; other site
637905010727	NAD(P) binding site [chemical binding]; other site
637905010728	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
637905010729	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
637905010730	NAD(P) binding pocket [chemical binding]; other site
637905010731	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530
637905010732	metal binding site [ion binding]; metal-binding site
637905010733	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
637905010734	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
637905010735	FMN binding site [chemical binding]; other site
637905010736	substrate binding site [chemical binding]; other site
637905010737	putative catalytic residue [active]
637905010738	Sulphur transport; Region: Sulf_transp; pfam04143
637905010739	Nitronate monooxygenase; Region: NMO; pfam03060
637905010740	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
637905010741	FMN binding site [chemical binding]; other site
637905010742	substrate binding site [chemical binding]; other site
637905010743	putative catalytic residue [active]
637905010744	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
637905010745	Sulfatase; Region: Sulfatase; cl17466
637905010746	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
637905010747	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
637905010748	glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417
637905010749	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
637905010750	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
637905010751	putative C-terminal domain interface [polypeptide binding]; other site
637905010752	putative GSH binding site (G-site) [chemical binding]; other site
637905010753	putative dimer interface [polypeptide binding]; other site
637905010754	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
637905010755	N-terminal domain interface [polypeptide binding]; other site
637905010756	dimer interface [polypeptide binding]; other site
637905010757	substrate binding pocket (H-site) [chemical binding]; other site
637905010758	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
637905010759	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
637905010760	potential catalytic triad [active]
637905010761	conserved cys residue [active]
637905010762	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
637905010763	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
637905010764	dimer interface [polypeptide binding]; other site
637905010765	active site
637905010766	metal binding site [ion binding]; metal-binding site
637905010767	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
637905010768	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
637905010769	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
637905010770	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
637905010771	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
637905010772	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
637905010773	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
637905010774	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
637905010775	putative acyl-acceptor binding pocket; other site
637905010776	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
637905010777	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
637905010778	putative acyl-acceptor binding pocket; other site
637905010779	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
637905010780	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
637905010781	Gram-negative bacterial tonB protein; Region: TonB; cl10048
637905010782	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
637905010783	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
637905010784	homodimer interface [polypeptide binding]; other site
637905010785	substrate-cofactor binding pocket; other site
637905010786	catalytic residue [active]
637905010787	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
637905010788	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
637905010789	Protein of unknown function (DUF904); Region: DUF904; pfam06005
637905010790	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
637905010791	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
637905010792	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
637905010793	catalytic residues [active]
637905010794	hinge region; other site
637905010795	alpha helical domain; other site
637905010796	serine/threonine protein kinase; Provisional; Region: PRK11768
637905010797	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
637905010798	Protein of unknown function (DUF3630); Region: DUF3630; pfam12305
637905010799	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
637905010800	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
637905010801	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
637905010802	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
637905010803	putative amphipathic alpha helix; other site
637905010804	Uncharacterized conserved protein [Function unknown]; Region: COG3339
637905010805	hypothetical protein; Provisional; Region: PRK01254
637905010806	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
637905010807	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
637905010808	MAPEG family; Region: MAPEG; cl09190
637905010809	Uncharacterized conserved protein [Function unknown]; Region: COG2966
637905010810	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
637905010811	Uncharacterized conserved protein [Function unknown]; Region: COG3610
637905010812	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
637905010813	Surface antigen; Region: Bac_surface_Ag; pfam01103
637905010814	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
637905010815	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
637905010816	Substrate binding site; other site
637905010817	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
637905010818	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
637905010819	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
637905010820	active site
637905010821	substrate binding site [chemical binding]; other site
637905010822	metal binding site [ion binding]; metal-binding site
637905010823	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
637905010824	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
637905010825	active site
637905010826	acyl-CoA synthetase; Validated; Region: PRK05850
637905010827	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
637905010828	acyl-activating enzyme (AAE) consensus motif; other site
637905010829	active site
637905010830	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
637905010831	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
637905010832	NAD(P) binding site [chemical binding]; other site
637905010833	active site
637905010834	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
637905010835	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
637905010836	acyl-activating enzyme (AAE) consensus motif; other site
637905010837	AMP binding site [chemical binding]; other site
637905010838	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
637905010839	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
637905010840	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
637905010841	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
637905010842	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
637905010843	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
637905010844	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
637905010845	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
637905010846	putative SAM binding site [chemical binding]; other site
637905010847	putative homodimer interface [polypeptide binding]; other site
637905010848	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
637905010849	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
637905010850	putative ligand binding site [chemical binding]; other site
637905010851	hypothetical protein; Reviewed; Region: PRK12497
637905010852	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
637905010853	dimer interface [polypeptide binding]; other site
637905010854	active site
637905010855	outer membrane lipoprotein; Provisional; Region: PRK11023
637905010856	BON domain; Region: BON; pfam04972
637905010857	BON domain; Region: BON; pfam04972
637905010858	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
637905010859	EamA-like transporter family; Region: EamA; pfam00892
637905010860	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
637905010861	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
637905010862	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
637905010863	dimerization interface [polypeptide binding]; other site
637905010864	substrate binding pocket [chemical binding]; other site
637905010865	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
637905010866	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
637905010867	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
637905010868	active site
637905010869	HIGH motif; other site
637905010870	dimer interface [polypeptide binding]; other site
637905010871	KMSKS motif; other site
637905010872	phosphoglycolate phosphatase; Provisional; Region: PRK13222
637905010873	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
637905010874	motif II; other site
637905010875	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
637905010876	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
637905010877	substrate binding site [chemical binding]; other site
637905010878	hexamer interface [polypeptide binding]; other site
637905010879	metal binding site [ion binding]; metal-binding site
637905010880	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
637905010881	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
637905010882	AAA ATPase domain; Region: AAA_16; pfam13191
637905010883	AAA domain; Region: AAA_22; pfam13401
637905010884	Sporulation related domain; Region: SPOR; pfam05036
637905010885	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
637905010886	active site
637905010887	dimer interface [polypeptide binding]; other site
637905010888	metal binding site [ion binding]; metal-binding site
637905010889	shikimate kinase; Reviewed; Region: aroK; PRK00131
637905010890	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
637905010891	ADP binding site [chemical binding]; other site
637905010892	magnesium binding site [ion binding]; other site
637905010893	putative shikimate binding site; other site
637905010894	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
637905010895	Secretin and TonB N terminus short domain; Region: STN; smart00965
637905010896	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
637905010897	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
637905010898	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
637905010899	Pilus assembly protein, PilP; Region: PilP; pfam04351
637905010900	Pilus assembly protein, PilO; Region: PilO; pfam04350
637905010901	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
637905010902	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
637905010903	Cell division protein FtsA; Region: FtsA; cl17206
637905010904	Competence protein A; Region: Competence_A; pfam11104
637905010905	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
637905010906	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
637905010907	Transglycosylase; Region: Transgly; pfam00912
637905010908	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
637905010909	argininosuccinate lyase; Provisional; Region: PRK04833
637905010910	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
637905010911	active sites [active]
637905010912	tetramer interface [polypeptide binding]; other site
637905010913	argininosuccinate synthase; Provisional; Region: PRK13820
637905010914	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
637905010915	ANP binding site [chemical binding]; other site
637905010916	Substrate Binding Site II [chemical binding]; other site
637905010917	Substrate Binding Site I [chemical binding]; other site
637905010918	ornithine carbamoyltransferase; Provisional; Region: PRK14805
637905010919	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
637905010920	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
637905010921	acetylglutamate kinase; Provisional; Region: PRK00942
637905010922	nucleotide binding site [chemical binding]; other site
637905010923	substrate binding site [chemical binding]; other site
637905010924	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
637905010925	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
637905010926	acetylornithine deacetylase; Provisional; Region: PRK05111
637905010927	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
637905010928	metal binding site [ion binding]; metal-binding site
637905010929	putative dimer interface [polypeptide binding]; other site
637905010930	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
637905010931	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
637905010932	Protein of unknown function (DUF1439); Region: DUF1439; pfam07273
637905010933	competence damage-inducible protein A; Provisional; Region: PRK00549
637905010934	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
637905010935	putative MPT binding site; other site
637905010936	Competence-damaged protein; Region: CinA; pfam02464
637905010937	preprotein translocase subunit SecA; Reviewed; Region: PRK13107
637905010938	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
637905010939	SEC-C motif; Region: SEC-C; pfam02810
637905010940	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
637905010941	Peptidase family M23; Region: Peptidase_M23; pfam01551
637905010942	Protein of unknown function (DUF721); Region: DUF721; cl02324
637905010943	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
637905010944	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
637905010945	cell division protein FtsZ; Validated; Region: PRK09330
637905010946	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
637905010947	nucleotide binding site [chemical binding]; other site
637905010948	SulA interaction site; other site
637905010949	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
637905010950	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
637905010951	Cell division protein FtsA; Region: FtsA; pfam14450
637905010952	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
637905010953	Cell division protein FtsQ; Region: FtsQ; pfam03799
637905010954	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
637905010955	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
637905010956	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
637905010957	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
637905010958	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
637905010959	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
637905010960	active site
637905010961	homodimer interface [polypeptide binding]; other site
637905010962	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
637905010963	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
637905010964	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
637905010965	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
637905010966	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
637905010967	Mg++ binding site [ion binding]; other site
637905010968	putative catalytic motif [active]
637905010969	putative substrate binding site [chemical binding]; other site
637905010970	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
637905010971	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
637905010972	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
637905010973	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
637905010974	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
637905010975	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
637905010976	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
637905010977	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
637905010978	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
637905010979	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
637905010980	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
637905010981	Cell division protein FtsL; Region: FtsL; pfam04999
637905010982	MraW methylase family; Region: Methyltransf_5; pfam01795
637905010983	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
637905010984	cell division protein MraZ; Reviewed; Region: PRK00326
637905010985	MraZ protein; Region: MraZ; pfam02381
637905010986	MraZ protein; Region: MraZ; pfam02381
637905010987	glycerol kinase; Provisional; Region: glpK; PRK00047
637905010988	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
637905010989	N- and C-terminal domain interface [polypeptide binding]; other site
637905010990	active site
637905010991	MgATP binding site [chemical binding]; other site
637905010992	catalytic site [active]
637905010993	metal binding site [ion binding]; metal-binding site
637905010994	glycerol binding site [chemical binding]; other site
637905010995	homotetramer interface [polypeptide binding]; other site
637905010996	homodimer interface [polypeptide binding]; other site
637905010997	FBP binding site [chemical binding]; other site
637905010998	protein IIAGlc interface [polypeptide binding]; other site
637905010999	SnoaL-like domain; Region: SnoaL_2; pfam12680
637905011000	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
637905011001	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
637905011002	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
637905011003	substrate binding site [chemical binding]; other site
637905011004	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
637905011005	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
637905011006	substrate binding site [chemical binding]; other site
637905011007	ligand binding site [chemical binding]; other site
637905011008	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
637905011009	tartrate dehydrogenase; Region: TTC; TIGR02089
637905011010	2-isopropylmalate synthase; Validated; Region: PRK00915
637905011011	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
637905011012	active site
637905011013	catalytic residues [active]
637905011014	metal binding site [ion binding]; metal-binding site
637905011015	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
637905011016	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
637905011017	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637905011018	ATP binding site [chemical binding]; other site
637905011019	putative Mg++ binding site [ion binding]; other site
637905011020	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905011021	nucleotide binding region [chemical binding]; other site
637905011022	ATP-binding site [chemical binding]; other site
637905011023	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
637905011024	HRDC domain; Region: HRDC; pfam00570
637905011025	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
637905011026	CoenzymeA binding site [chemical binding]; other site
637905011027	subunit interaction site [polypeptide binding]; other site
637905011028	PHB binding site; other site
637905011029	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
637905011030	N-acetylglutamate synthase; Validated; Region: PRK05279
637905011031	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
637905011032	putative feedback inhibition sensing region; other site
637905011033	putative nucleotide binding site [chemical binding]; other site
637905011034	putative substrate binding site [chemical binding]; other site
637905011035	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637905011036	Coenzyme A binding pocket [chemical binding]; other site
637905011037	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
637905011038	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
637905011039	hypothetical protein; Reviewed; Region: PRK00024
637905011040	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
637905011041	MPN+ (JAMM) motif; other site
637905011042	Zinc-binding site [ion binding]; other site
637905011043	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
637905011044	Flavoprotein; Region: Flavoprotein; pfam02441
637905011045	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
637905011046	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
637905011047	trimer interface [polypeptide binding]; other site
637905011048	active site
637905011049	division inhibitor protein; Provisional; Region: slmA; PRK09480
637905011050	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
637905011051	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
637905011052	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
637905011053	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
637905011054	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
637905011055	active site
637905011056	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
637905011057	active site
637905011058	ribonuclease PH; Reviewed; Region: rph; PRK00173
637905011059	Ribonuclease PH; Region: RNase_PH_bact; cd11362
637905011060	hexamer interface [polypeptide binding]; other site
637905011061	active site
637905011062	hypothetical protein; Provisional; Region: PRK11820
637905011063	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
637905011064	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
637905011065	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
637905011066	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905011067	putative substrate translocation pore; other site
637905011068	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
637905011069	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
637905011070	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
637905011071	HAMP domain; Region: HAMP; pfam00672
637905011072	dimerization interface [polypeptide binding]; other site
637905011073	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
637905011074	phosphorylation site [posttranslational modification]
637905011075	dimer interface [polypeptide binding]; other site
637905011076	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905011077	ATP binding site [chemical binding]; other site
637905011078	Mg2+ binding site [ion binding]; other site
637905011079	G-X-G motif; other site
637905011080	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905011081	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
637905011082	active site
637905011083	phosphorylation site [posttranslational modification]
637905011084	intermolecular recognition site; other site
637905011085	dimerization interface [polypeptide binding]; other site
637905011086	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
637905011087	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
637905011088	Phosphotransferase enzyme family; Region: APH; pfam01636
637905011089	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
637905011090	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
637905011091	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
637905011092	catalytic site [active]
637905011093	G-X2-G-X-G-K; other site
637905011094	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
637905011095	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
637905011096	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
637905011097	Zn2+ binding site [ion binding]; other site
637905011098	Mg2+ binding site [ion binding]; other site
637905011099	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
637905011100	synthetase active site [active]
637905011101	NTP binding site [chemical binding]; other site
637905011102	metal binding site [ion binding]; metal-binding site
637905011103	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
637905011104	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
637905011105	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
637905011106	homotrimer interaction site [polypeptide binding]; other site
637905011107	putative active site [active]
637905011108	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
637905011109	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
637905011110	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
637905011111	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
637905011112	catalytic motif [active]
637905011113	Zn binding site [ion binding]; other site
637905011114	FRG domain; Region: FRG; pfam08867
637905011115	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
637905011116	Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932
637905011117	acyl-activating enzyme (AAE) consensus motif; other site
637905011118	putative AMP binding site [chemical binding]; other site
637905011119	putative active site [active]
637905011120	putative CoA binding site [chemical binding]; other site
637905011121	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
637905011122	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
637905011123	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
637905011124	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
637905011125	Y-family of DNA polymerases; Region: PolY; cl12025
637905011126	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
637905011127	generic binding surface II; other site
637905011128	ssDNA binding site; other site
637905011129	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
637905011130	ATP binding site [chemical binding]; other site
637905011131	putative Mg++ binding site [ion binding]; other site
637905011132	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
637905011133	nucleotide binding region [chemical binding]; other site
637905011134	ATP-binding site [chemical binding]; other site
637905011135	Protein of unknown function (DUF3014); Region: DUF3014; pfam11219
637905011136	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
637905011137	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
637905011138	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
637905011139	putative acyl-acceptor binding pocket; other site
637905011140	Phosphopantetheine attachment site; Region: PP-binding; cl09936
637905011141	acyl carrier protein; Provisional; Region: PRK05350
637905011142	Predicted membrane protein [Function unknown]; Region: COG4648
637905011143	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
637905011144	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
637905011145	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
637905011146	acyl-activating enzyme (AAE) consensus motif; other site
637905011147	acyl-activating enzyme (AAE) consensus motif; other site
637905011148	AMP binding site [chemical binding]; other site
637905011149	active site
637905011150	CoA binding site [chemical binding]; other site
637905011151	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
637905011152	active site 2 [active]
637905011153	dimer interface [polypeptide binding]; other site
637905011154	active site 1 [active]
637905011155	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
637905011156	Ligand binding site; other site
637905011157	Putative Catalytic site; other site
637905011158	DXD motif; other site
637905011159	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
637905011160	putative acyl-acceptor binding pocket; other site
637905011161	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
637905011162	active sites [active]
637905011163	tetramer interface [polypeptide binding]; other site
637905011164	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
637905011165	active site
637905011166	Predicted exporter [General function prediction only]; Region: COG4258
637905011167	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
637905011168	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
637905011169	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
637905011170	Protein of unknown function (DUF3261); Region: DUF3261; pfam11659
637905011171	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
637905011172	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
637905011173	dimer interface [polypeptide binding]; other site
637905011174	active site
637905011175	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
637905011176	putative active site 1 [active]
637905011177	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
637905011178	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
637905011179	NAD(P) binding site [chemical binding]; other site
637905011180	homotetramer interface [polypeptide binding]; other site
637905011181	homodimer interface [polypeptide binding]; other site
637905011182	active site
637905011183	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
637905011184	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
637905011185	dimer interface [polypeptide binding]; other site
637905011186	active site
637905011187	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
637905011188	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
637905011189	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
637905011190	putative active site [active]
637905011191	dimerization interface [polypeptide binding]; other site
637905011192	putative tRNAtyr binding site [nucleotide binding]; other site
637905011193	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
637905011194	hypothetical protein; Reviewed; Region: PRK01637
637905011195	Protein of unknown function (DUF2959); Region: DUF2959; pfam11172
637905011196	Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560
637905011197	putative active site [active]
637905011198	catalytic site [active]
637905011199	putative metal binding site [ion binding]; other site
637905011200	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
637905011201	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
637905011202	G1 box; other site
637905011203	putative GEF interaction site [polypeptide binding]; other site
637905011204	GTP/Mg2+ binding site [chemical binding]; other site
637905011205	Switch I region; other site
637905011206	G2 box; other site
637905011207	G3 box; other site
637905011208	Switch II region; other site
637905011209	G4 box; other site
637905011210	G5 box; other site
637905011211	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
637905011212	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
637905011213	glutamine synthetase; Provisional; Region: glnA; PRK09469
637905011214	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
637905011215	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
637905011216	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
637905011217	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
637905011218	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
637905011219	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
637905011220	PAS domain; Region: PAS; smart00091
637905011221	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
637905011222	dimer interface [polypeptide binding]; other site
637905011223	phosphorylation site [posttranslational modification]
637905011224	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905011225	ATP binding site [chemical binding]; other site
637905011226	Mg2+ binding site [ion binding]; other site
637905011227	G-X-G motif; other site
637905011228	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
637905011229	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905011230	active site
637905011231	phosphorylation site [posttranslational modification]
637905011232	intermolecular recognition site; other site
637905011233	dimerization interface [polypeptide binding]; other site
637905011234	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
637905011235	Walker A motif; other site
637905011236	ATP binding site [chemical binding]; other site
637905011237	Walker B motif; other site
637905011238	arginine finger; other site
637905011239	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
637905011240	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
637905011241	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
637905011242	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
637905011243	catalytic residues [active]
637905011244	central insert; other site
637905011245	cytochrome c nitrate reductase biogenesis protein NrfE; Region: cyt_nit_nrfE; TIGR03145
637905011246	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
637905011247	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
637905011248	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
637905011249	binding surface
637905011250	TPR motif; other site
637905011251	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
637905011252	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
637905011253	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
637905011254	Walker A/P-loop; other site
637905011255	ATP binding site [chemical binding]; other site
637905011256	Q-loop/lid; other site
637905011257	ABC transporter signature motif; other site
637905011258	Walker B; other site
637905011259	D-loop; other site
637905011260	H-loop/switch region; other site
637905011261	heme exporter protein CcmB; Region: ccmB; TIGR01190
637905011262	heme exporter protein CcmC; Region: ccmC; TIGR01191
637905011263	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
637905011264	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
637905011265	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
637905011266	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
637905011267	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
637905011268	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
637905011269	alphaNTD homodimer interface [polypeptide binding]; other site
637905011270	alphaNTD - beta interaction site [polypeptide binding]; other site
637905011271	alphaNTD - beta' interaction site [polypeptide binding]; other site
637905011272	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
637905011273	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
637905011274	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
637905011275	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
637905011276	RNA binding surface [nucleotide binding]; other site
637905011277	30S ribosomal protein S11; Validated; Region: PRK05309
637905011278	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
637905011279	30S ribosomal protein S13; Region: bact_S13; TIGR03631
637905011280	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
637905011281	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
637905011282	SecY translocase; Region: SecY; pfam00344
637905011283	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
637905011284	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
637905011285	23S rRNA binding site [nucleotide binding]; other site
637905011286	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
637905011287	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
637905011288	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
637905011289	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
637905011290	5S rRNA interface [nucleotide binding]; other site
637905011291	23S rRNA interface [nucleotide binding]; other site
637905011292	L5 interface [polypeptide binding]; other site
637905011293	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
637905011294	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
637905011295	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
637905011296	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
637905011297	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
637905011298	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
637905011299	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
637905011300	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
637905011301	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
637905011302	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
637905011303	RNA binding site [nucleotide binding]; other site
637905011304	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
637905011305	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
637905011306	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
637905011307	23S rRNA interface [nucleotide binding]; other site
637905011308	putative translocon interaction site; other site
637905011309	signal recognition particle (SRP54) interaction site; other site
637905011310	L23 interface [polypeptide binding]; other site
637905011311	trigger factor interaction site; other site
637905011312	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
637905011313	23S rRNA interface [nucleotide binding]; other site
637905011314	5S rRNA interface [nucleotide binding]; other site
637905011315	putative antibiotic binding site [chemical binding]; other site
637905011316	L25 interface [polypeptide binding]; other site
637905011317	L27 interface [polypeptide binding]; other site
637905011318	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
637905011319	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
637905011320	G-X-X-G motif; other site
637905011321	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
637905011322	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
637905011323	putative translocon binding site; other site
637905011324	protein-rRNA interface [nucleotide binding]; other site
637905011325	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
637905011326	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
637905011327	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
637905011328	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
637905011329	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
637905011330	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
637905011331	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
637905011332	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
637905011333	elongation factor Tu; Reviewed; Region: PRK00049
637905011334	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
637905011335	G1 box; other site
637905011336	GEF interaction site [polypeptide binding]; other site
637905011337	GTP/Mg2+ binding site [chemical binding]; other site
637905011338	Switch I region; other site
637905011339	G2 box; other site
637905011340	G3 box; other site
637905011341	Switch II region; other site
637905011342	G4 box; other site
637905011343	G5 box; other site
637905011344	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
637905011345	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
637905011346	Antibiotic Binding Site [chemical binding]; other site
637905011347	elongation factor G; Reviewed; Region: PRK00007
637905011348	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
637905011349	G1 box; other site
637905011350	putative GEF interaction site [polypeptide binding]; other site
637905011351	GTP/Mg2+ binding site [chemical binding]; other site
637905011352	Switch I region; other site
637905011353	G2 box; other site
637905011354	G3 box; other site
637905011355	Switch II region; other site
637905011356	G4 box; other site
637905011357	G5 box; other site
637905011358	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
637905011359	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
637905011360	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
637905011361	30S ribosomal protein S7; Validated; Region: PRK05302
637905011362	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
637905011363	S17 interaction site [polypeptide binding]; other site
637905011364	S8 interaction site; other site
637905011365	16S rRNA interaction site [nucleotide binding]; other site
637905011366	streptomycin interaction site [chemical binding]; other site
637905011367	23S rRNA interaction site [nucleotide binding]; other site
637905011368	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
637905011369	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
637905011370	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
637905011371	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
637905011372	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
637905011373	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
637905011374	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
637905011375	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
637905011376	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
637905011377	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
637905011378	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
637905011379	DNA binding site [nucleotide binding]
637905011380	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
637905011381	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
637905011382	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
637905011383	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
637905011384	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
637905011385	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
637905011386	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
637905011387	RPB3 interaction site [polypeptide binding]; other site
637905011388	RPB1 interaction site [polypeptide binding]; other site
637905011389	RPB11 interaction site [polypeptide binding]; other site
637905011390	RPB10 interaction site [polypeptide binding]; other site
637905011391	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
637905011392	L11 interface [polypeptide binding]; other site
637905011393	putative EF-Tu interaction site [polypeptide binding]; other site
637905011394	putative EF-G interaction site [polypeptide binding]; other site
637905011395	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
637905011396	23S rRNA interface [nucleotide binding]; other site
637905011397	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
637905011398	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
637905011399	mRNA/rRNA interface [nucleotide binding]; other site
637905011400	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
637905011401	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
637905011402	23S rRNA interface [nucleotide binding]; other site
637905011403	L7/L12 interface [polypeptide binding]; other site
637905011404	putative thiostrepton binding site; other site
637905011405	L25 interface [polypeptide binding]; other site
637905011406	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
637905011407	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
637905011408	putative homodimer interface [polypeptide binding]; other site
637905011409	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
637905011410	heterodimer interface [polypeptide binding]; other site
637905011411	homodimer interface [polypeptide binding]; other site
637905011412	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
637905011413	elongation factor Tu; Reviewed; Region: PRK00049
637905011414	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
637905011415	G1 box; other site
637905011416	GEF interaction site [polypeptide binding]; other site
637905011417	GTP/Mg2+ binding site [chemical binding]; other site
637905011418	Switch I region; other site
637905011419	G2 box; other site
637905011420	G3 box; other site
637905011421	Switch II region; other site
637905011422	G4 box; other site
637905011423	G5 box; other site
637905011424	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
637905011425	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
637905011426	Antibiotic Binding Site [chemical binding]; other site
637905011427	pantothenate kinase; Provisional; Region: PRK05439
637905011428	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
637905011429	ATP-binding site [chemical binding]; other site
637905011430	CoA-binding site [chemical binding]; other site
637905011431	Mg2+-binding site [ion binding]; other site
637905011432	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
637905011433	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
637905011434	putative Zn2+ binding site [ion binding]; other site
637905011435	putative DNA binding site [nucleotide binding]; other site
637905011436	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
637905011437	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
637905011438	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
637905011439	FAD binding domain; Region: FAD_binding_4; pfam01565
637905011440	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
637905011441	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
637905011442	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
637905011443	glutamate racemase; Provisional; Region: PRK00865
637905011444	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
637905011445	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
637905011446	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905011447	S-adenosylmethionine binding site [chemical binding]; other site
637905011448	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
637905011449	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
637905011450	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
637905011451	Fatty acid desaturase; Region: FA_desaturase; pfam00487
637905011452	Di-iron ligands [ion binding]; other site
637905011453	selenophosphate synthetase; Provisional; Region: PRK00943
637905011454	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
637905011455	dimerization interface [polypeptide binding]; other site
637905011456	putative ATP binding site [chemical binding]; other site
637905011457	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
637905011458	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
637905011459	active site residue [active]
637905011460	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
637905011461	putative substrate translocation pore; other site
637905011462	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
637905011463	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
637905011464	active site
637905011465	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
637905011466	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
637905011467	dimer interface [polypeptide binding]; other site
637905011468	ADP-ribose binding site [chemical binding]; other site
637905011469	active site
637905011470	nudix motif; other site
637905011471	metal binding site [ion binding]; metal-binding site
637905011472	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
637905011473	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
637905011474	motif II; other site
637905011475	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
637905011476	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
637905011477	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
637905011478	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
637905011479	GspL periplasmic domain; Region: GspL_C; pfam12693
637905011480	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
637905011481	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
637905011482	type II secretion system protein J; Region: gspJ; TIGR01711
637905011483	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
637905011484	Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963
637905011485	type II secretion system protein I; Region: gspI; TIGR01707
637905011486	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
637905011487	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
637905011488	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
637905011489	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
637905011490	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
637905011491	type II secretion system protein F; Region: GspF; TIGR02120
637905011492	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
637905011493	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
637905011494	type II secretion system protein E; Region: type_II_gspE; TIGR02533
637905011495	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
637905011496	Walker A motif; other site
637905011497	ATP binding site [chemical binding]; other site
637905011498	Walker B motif; other site
637905011499	type II secretion system protein D; Region: type_II_gspD; TIGR02517
637905011500	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
637905011501	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
637905011502	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
637905011503	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
637905011504	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
637905011505	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
637905011506	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
637905011507	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
637905011508	RNA binding surface [nucleotide binding]; other site
637905011509	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
637905011510	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
637905011511	dimerization interface [polypeptide binding]; other site
637905011512	domain crossover interface; other site
637905011513	redox-dependent activation switch; other site
637905011514	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
637905011515	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241
637905011516	putative active site [active]
637905011517	Zn binding site [ion binding]; other site
637905011518	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
637905011519	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
637905011520	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905011521	N-terminal plug; other site
637905011522	ligand-binding site [chemical binding]; other site
637905011523	Methyltransferase domain; Region: Methyltransf_23; pfam13489
637905011524	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905011525	S-adenosylmethionine binding site [chemical binding]; other site
637905011526	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
637905011527	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
637905011528	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
637905011529	active site
637905011530	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
637905011531	GIY-YIG motif/motif A; other site
637905011532	putative active site [active]
637905011533	putative metal binding site [ion binding]; other site
637905011534	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
637905011535	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
637905011536	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
637905011537	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
637905011538	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
637905011539	Ferritin-like domain; Region: Ferritin; pfam00210
637905011540	ferroxidase diiron center [ion binding]; other site
637905011541	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
637905011542	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
637905011543	HlyD family secretion protein; Region: HlyD_3; pfam13437
637905011544	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
637905011545	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
637905011546	dimer interface [polypeptide binding]; other site
637905011547	putative functional site; other site
637905011548	putative MPT binding site; other site
637905011549	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
637905011550	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
637905011551	ATP binding site [chemical binding]; other site
637905011552	substrate interface [chemical binding]; other site
637905011553	molybdopterin synthase sulfurylase MoeB; Region: moeB; TIGR02355
637905011554	molybdopterin synthase sulfurylase MoeB; Region: moeB; TIGR02355
637905011555	molybdopterin synthase sulfurylase MoeB; Region: moeB; TIGR02355
637905011556	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
637905011557	Domain of unknown function (DUF333); Region: DUF333; pfam03891
637905011558	Domain of unknown function (DUF333); Region: DUF333; pfam03891
637905011559	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
637905011560	Domain of unknown function (DUF333); Region: DUF333; pfam03891
637905011561	Domain of unknown function (DUF333); Region: DUF333; pfam03891
637905011562	Domain of unknown function (DUF333); Region: DUF333; pfam03891
637905011563	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
637905011564	active site
637905011565	ATP binding site [chemical binding]; other site
637905011566	Phosphotransferase enzyme family; Region: APH; pfam01636
637905011567	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
637905011568	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
637905011569	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
637905011570	DNA binding residues [nucleotide binding]
637905011571	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
637905011572	hypothetical protein; Provisional; Region: PRK05409
637905011573	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
637905011574	Sodium/glutamate symporter; Region: Glt_symporter; pfam03616
637905011575	Protein of unknown function (DUF2986); Region: DUF2986; pfam11661
637905011576	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
637905011577	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
637905011578	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
637905011579	active site
637905011580	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
637905011581	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
637905011582	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
637905011583	dimer interface [polypeptide binding]; other site
637905011584	phosphorylation site [posttranslational modification]
637905011585	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
637905011586	ATP binding site [chemical binding]; other site
637905011587	Mg2+ binding site [ion binding]; other site
637905011588	G-X-G motif; other site
637905011589	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
637905011590	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905011591	active site
637905011592	phosphorylation site [posttranslational modification]
637905011593	intermolecular recognition site; other site
637905011594	dimerization interface [polypeptide binding]; other site
637905011595	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
637905011596	DNA binding site [nucleotide binding]
637905011597	Predicted membrane protein [Function unknown]; Region: COG3212
637905011598	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637905011599	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
637905011600	Walker A/P-loop; other site
637905011601	ATP binding site [chemical binding]; other site
637905011602	Q-loop/lid; other site
637905011603	ABC transporter signature motif; other site
637905011604	Walker B; other site
637905011605	D-loop; other site
637905011606	H-loop/switch region; other site
637905011607	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
637905011608	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
637905011609	dimer interface [polypeptide binding]; other site
637905011610	conserved gate region; other site
637905011611	putative PBP binding loops; other site
637905011612	ABC-ATPase subunit interface; other site
637905011613	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
637905011614	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
637905011615	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
637905011616	MoaE homodimer interface [polypeptide binding]; other site
637905011617	MoaD interaction [polypeptide binding]; other site
637905011618	active site residues [active]
637905011619	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
637905011620	MoaE interaction surface [polypeptide binding]; other site
637905011621	MoeB interaction surface [polypeptide binding]; other site
637905011622	thiocarboxylated glycine; other site
637905011623	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
637905011624	trimer interface [polypeptide binding]; other site
637905011625	dimer interface [polypeptide binding]; other site
637905011626	putative active site [active]
637905011627	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
637905011628	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
637905011629	FeS/SAM binding site; other site
637905011630	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
637905011631	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
637905011632	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
637905011633	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
637905011634	Cache domain; Region: Cache_1; pfam02743
637905011635	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905011636	dimerization interface [polypeptide binding]; other site
637905011637	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
637905011638	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905011639	dimer interface [polypeptide binding]; other site
637905011640	putative CheW interface [polypeptide binding]; other site
637905011641	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
637905011642	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
637905011643	MOSC domain; Region: MOSC; pfam03473
637905011644	3-alpha domain; Region: 3-alpha; pfam03475
637905011645	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
637905011646	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
637905011647	substrate binding site [chemical binding]; other site
637905011648	ATP binding site [chemical binding]; other site
637905011649	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
637905011650	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
637905011651	Coenzyme A binding pocket [chemical binding]; other site
637905011652	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
637905011653	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
637905011654	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
637905011655	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
637905011656	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
637905011657	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905011658	S-adenosylmethionine binding site [chemical binding]; other site
637905011659	flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697
637905011660	Chorismate lyase; Region: Chor_lyase; cl01230
637905011661	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
637905011662	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
637905011663	alpha-glucosidase; Provisional; Region: PRK10137
637905011664	Trehalase; Region: Trehalase; cl17346
637905011665	MarC family integral membrane protein; Region: MarC; cl00919
637905011666	NRDE protein; Region: NRDE; cl01315
637905011667	Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains; Region: CY; cd00042
637905011668	putative proteinase inhibition site; other site
637905011669	SnoaL-like domain; Region: SnoaL_3; pfam13474
637905011670	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
637905011671	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
637905011672	putative acyl-acceptor binding pocket; other site
637905011673	LysE type translocator; Region: LysE; cl00565
637905011674	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
637905011675	Mechanosensitive ion channel; Region: MS_channel; pfam00924
637905011676	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
637905011677	Protein of unknown function (DUF3157); Region: DUF3157; pfam11355
637905011678	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
637905011679	active sites [active]
637905011680	tetramer interface [polypeptide binding]; other site
637905011681	urocanate hydratase; Provisional; Region: PRK05414
637905011682	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
637905011683	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
637905011684	DNA-binding site [nucleotide binding]; DNA binding site
637905011685	UTRA domain; Region: UTRA; pfam07702
637905011686	imidazolonepropionase; Validated; Region: PRK09356
637905011687	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
637905011688	active site
637905011689	SnoaL-like domain; Region: SnoaL_2; pfam12680
637905011690	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
637905011691	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
637905011692	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
637905011693	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905011694	N-terminal plug; other site
637905011695	ligand-binding site [chemical binding]; other site
637905011696	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
637905011697	Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229
637905011698	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
637905011699	active site
637905011700	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
637905011701	active site
637905011702	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
637905011703	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
637905011704	acyl-activating enzyme (AAE) consensus motif; other site
637905011705	putative AMP binding site [chemical binding]; other site
637905011706	putative active site [active]
637905011707	putative CoA binding site [chemical binding]; other site
637905011708	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
637905011709	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
637905011710	Walker A/P-loop; other site
637905011711	ATP binding site [chemical binding]; other site
637905011712	Q-loop/lid; other site
637905011713	ABC transporter signature motif; other site
637905011714	Walker B; other site
637905011715	D-loop; other site
637905011716	H-loop/switch region; other site
637905011717	Predicted transcriptional regulators [Transcription]; Region: COG1725
637905011718	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
637905011719	DNA-binding site [nucleotide binding]; DNA binding site
637905011720	TAP-like protein; Region: Abhydrolase_4; pfam08386
637905011721	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
637905011722	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
637905011723	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
637905011724	Walker A/P-loop; other site
637905011725	ATP binding site [chemical binding]; other site
637905011726	Q-loop/lid; other site
637905011727	ABC transporter signature motif; other site
637905011728	Walker B; other site
637905011729	D-loop; other site
637905011730	H-loop/switch region; other site
637905011731	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
637905011732	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
637905011733	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
637905011734	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
637905011735	conserved cys residue [active]
637905011736	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
637905011737	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
637905011738	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
637905011739	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
637905011740	dimerization interface [polypeptide binding]; other site
637905011741	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
637905011742	dimer interface [polypeptide binding]; other site
637905011743	putative CheW interface [polypeptide binding]; other site
637905011744	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
637905011745	MPT binding site; other site
637905011746	trimer interface [polypeptide binding]; other site
637905011747	NlpC/P60 family; Region: NLPC_P60; pfam00877
637905011748	HI0933-like protein; Region: HI0933_like; pfam03486
637905011749	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
637905011750	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
637905011751	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
637905011752	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
637905011753	SecA binding site; other site
637905011754	Preprotein binding site; other site
637905011755	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
637905011756	active site residue [active]
637905011757	phosphoglyceromutase; Provisional; Region: PRK05434
637905011758	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
637905011759	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
637905011760	Peptidase family M23; Region: Peptidase_M23; pfam01551
637905011761	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
637905011762	C-terminal peptidase (prc); Region: prc; TIGR00225
637905011763	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
637905011764	protein binding site [polypeptide binding]; other site
637905011765	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
637905011766	Catalytic dyad [active]
637905011767	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
637905011768	NodB motif; other site
637905011769	putative active site [active]
637905011770	putative catalytic site [active]
637905011771	Zn binding site [ion binding]; other site
637905011772	Transcriptional regulator; Region: Rrf2; cl17282
637905011773	Predicted transcriptional regulator [Transcription]; Region: COG1959
637905011774	Flagellin N-methylase; Region: FliB; pfam03692
637905011775	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
637905011776	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
637905011777	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
637905011778	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
637905011779	substrate binding site [chemical binding]; other site
637905011780	oxyanion hole (OAH) forming residues; other site
637905011781	trimer interface [polypeptide binding]; other site
637905011782	Predicted membrane protein [Function unknown]; Region: COG3205
637905011783	Histidine kinase; Region: His_kinase; pfam06580
637905011784	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
637905011785	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
637905011786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
637905011787	active site
637905011788	phosphorylation site [posttranslational modification]
637905011789	intermolecular recognition site; other site
637905011790	dimerization interface [polypeptide binding]; other site
637905011791	LytTr DNA-binding domain; Region: LytTR; smart00850
637905011792	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
637905011793	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905011794	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
637905011795	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
637905011796	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
637905011797	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
637905011798	Na2 binding site [ion binding]; other site
637905011799	putative substrate binding site 1 [chemical binding]; other site
637905011800	Na binding site 1 [ion binding]; other site
637905011801	putative substrate binding site 2 [chemical binding]; other site
637905011802	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
637905011803	Zn binding site [ion binding]; other site
637905011804	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
637905011805	UbiA prenyltransferase family; Region: UbiA; pfam01040
637905011806	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
637905011807	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
637905011808	Subunit I/III interface [polypeptide binding]; other site
637905011809	Subunit III/IV interface [polypeptide binding]; other site
637905011810	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
637905011811	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
637905011812	D-pathway; other site
637905011813	Putative ubiquinol binding site [chemical binding]; other site
637905011814	Low-spin heme (heme b) binding site [chemical binding]; other site
637905011815	Putative water exit pathway; other site
637905011816	Binuclear center (heme o3/CuB) [ion binding]; other site
637905011817	K-pathway; other site
637905011818	Putative proton exit pathway; other site
637905011819	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
637905011820	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
637905011821	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
637905011822	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
637905011823	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
637905011824	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
637905011825	glutaminase active site [active]
637905011826	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
637905011827	dimer interface [polypeptide binding]; other site
637905011828	active site
637905011829	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
637905011830	dimer interface [polypeptide binding]; other site
637905011831	active site
637905011832	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
637905011833	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
637905011834	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
637905011835	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
637905011836	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
637905011837	N-terminal plug; other site
637905011838	ligand-binding site [chemical binding]; other site
637905011839	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
637905011840	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
637905011841	Substrate binding site; other site
637905011842	Mg++ binding site; other site
637905011843	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
637905011844	active site
637905011845	substrate binding site [chemical binding]; other site
637905011846	CoA binding site [chemical binding]; other site
637905011847	DsrE/DsrF-like family; Region: DrsE; cl00672
637905011848	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
637905011849	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
637905011850	gamma subunit interface [polypeptide binding]; other site
637905011851	epsilon subunit interface [polypeptide binding]; other site
637905011852	LBP interface [polypeptide binding]; other site
637905011853	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
637905011854	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
637905011855	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
637905011856	alpha subunit interaction interface [polypeptide binding]; other site
637905011857	Walker A motif; other site
637905011858	ATP binding site [chemical binding]; other site
637905011859	Walker B motif; other site
637905011860	inhibitor binding site; inhibition site
637905011861	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
637905011862	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
637905011863	core domain interface [polypeptide binding]; other site
637905011864	delta subunit interface [polypeptide binding]; other site
637905011865	epsilon subunit interface [polypeptide binding]; other site
637905011866	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
637905011867	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
637905011868	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
637905011869	beta subunit interaction interface [polypeptide binding]; other site
637905011870	Walker A motif; other site
637905011871	ATP binding site [chemical binding]; other site
637905011872	Walker B motif; other site
637905011873	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
637905011874	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
637905011875	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
637905011876	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
637905011877	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
637905011878	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
637905011879	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
637905011880	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
637905011881	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
637905011882	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
637905011883	ParB-like nuclease domain; Region: ParBc; pfam02195
637905011884	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
637905011885	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
637905011886	P-loop; other site
637905011887	Magnesium ion binding site [ion binding]; other site
637905011888	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
637905011889	Magnesium ion binding site [ion binding]; other site
637905011890	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
637905011891	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
637905011892	S-adenosylmethionine binding site [chemical binding]; other site
637905011893	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
637905011894	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
637905011895	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932