-- dump date 20140620_065015 -- class Genbank::misc_feature -- table misc_feature_note -- id note 754093000001 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 754093000002 active site 754093000003 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 754093000004 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093000005 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093000006 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093000007 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 754093000008 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 754093000009 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 754093000010 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 754093000011 HTH-like domain; Region: HTH_21; pfam13276 754093000012 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 754093000013 Integrase core domain; Region: rve_3; pfam13683 754093000014 Transposase; Region: HTH_Tnp_1; cl17663 754093000015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093000016 Salmonella virulence-associated 28kDa protein; Region: VRP3; pfam03536 754093000017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754093000018 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754093000019 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754093000020 IS2 transposase TnpB; Reviewed; Region: PRK09409 754093000021 Putative transposase; Region: Y2_Tnp; pfam04986 754093000022 Transposase; Region: HTH_Tnp_1; pfam01527 754093000023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093000024 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 754093000025 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 754093000026 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 754093000027 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 754093000028 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 754093000029 putative transposase OrfB; Reviewed; Region: PHA02517 754093000030 HTH-like domain; Region: HTH_21; pfam13276 754093000031 Integrase core domain; Region: rve; pfam00665 754093000032 Integrase core domain; Region: rve_2; pfam13333 754093000033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093000034 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093000035 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093000036 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 754093000037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 754093000038 Integrase core domain; Region: rve; pfam00665 754093000039 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 754093000040 Integrase core domain; Region: rve; pfam00665 754093000041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 754093000042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 754093000043 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093000044 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 754093000045 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 754093000046 Magnesium ion binding site [ion binding]; other site 754093000047 ParB-like nuclease domain; Region: ParB; smart00470 754093000048 ParB family; Region: ParB; pfam08775 754093000049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 754093000050 Transposase; Region: DEDD_Tnp_IS110; pfam01548 754093000051 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 754093000052 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 754093000053 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 754093000054 putative active site [active] 754093000055 putative NTP binding site [chemical binding]; other site 754093000056 putative nucleic acid binding site [nucleotide binding]; other site 754093000057 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 754093000058 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 754093000059 putative transposase OrfB; Reviewed; Region: PHA02517 754093000060 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 754093000061 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 754093000062 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 754093000063 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 754093000064 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 754093000065 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093000066 Integrase core domain; Region: rve; pfam00665 754093000067 Integrase core domain; Region: rve_3; pfam13683 754093000068 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 754093000069 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 754093000070 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 754093000071 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093000072 Transposase; Region: DEDD_Tnp_IS110; pfam01548 754093000073 Shigella flexneri OspC protein; Region: Shigella_OspC; pfam06128 754093000074 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 754093000075 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 754093000076 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 754093000077 membrane-bound complex binding site; other site 754093000078 hinge residues; other site 754093000079 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093000080 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093000081 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093000082 MULE transposase domain; Region: MULE; pfam10551 754093000083 Integrase core domain; Region: rve_3; cl15866 754093000084 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093000085 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 754093000086 active site 754093000087 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 754093000088 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 754093000089 PRTRC system protein D; Region: PRTRC_D; TIGR03739 754093000090 Mg binding site [ion binding]; other site 754093000091 nucleotide binding site [chemical binding]; other site 754093000092 putative protofilament interface [polypeptide binding]; other site 754093000093 Transposase; Region: HTH_Tnp_1; cl17663 754093000094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093000095 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093000096 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093000097 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093000098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 754093000099 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 754093000100 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 754093000101 Predicted transcriptional regulator [Transcription]; Region: COG3905 754093000102 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 754093000103 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 754093000104 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 754093000105 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 754093000106 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 754093000107 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 754093000108 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093000109 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 754093000110 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 754093000111 serine/threonine protein kinase; Provisional; Region: PRK14879 754093000112 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 754093000113 putative active site [active] 754093000114 putative metal binding site [ion binding]; other site 754093000115 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754093000116 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 754093000117 Protein of unknown function (DUF535); Region: DUF535; pfam04393 754093000118 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 754093000119 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 754093000120 putative acyl-acceptor binding pocket; other site 754093000121 Transposase; Region: HTH_Tnp_1; pfam01527 754093000122 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093000123 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 754093000124 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 754093000125 putative active site [active] 754093000126 putative NTP binding site [chemical binding]; other site 754093000127 putative nucleic acid binding site [nucleotide binding]; other site 754093000128 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 754093000129 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 754093000130 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 754093000131 Staphylococcal nuclease homologues; Region: SNc; smart00318 754093000132 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 754093000133 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 754093000134 Homeodomain-like domain; Region: HTH_23; pfam13384 754093000135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093000136 Transposase; Region: HTH_Tnp_1; pfam01527 754093000137 HTH-like domain; Region: HTH_21; pfam13276 754093000138 Integrase core domain; Region: rve; pfam00665 754093000139 Integrase core domain; Region: rve_2; pfam13333 754093000140 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 754093000141 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 754093000142 Tetratricopeptide repeat; Region: TPR_3; pfam07720 754093000143 Tetratricopeptide repeat; Region: TPR_3; pfam07720 754093000144 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 754093000145 invasion protein OrgB; Provisional; Region: PRK15322 754093000146 ATP synthase SpaL; Validated; Region: PRK08149 754093000147 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 754093000148 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 754093000149 Walker A motif; other site 754093000150 ATP binding site [chemical binding]; other site 754093000151 Walker B motif; other site 754093000152 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 754093000153 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 754093000154 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 754093000155 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754093000156 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754093000157 Putative transposase; Region: Y2_Tnp; pfam04986 754093000158 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 754093000159 Transposase; Region: HTH_Tnp_1; cl17663 754093000160 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093000161 Omptin family; Region: Omptin; pfam01278 754093000162 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 754093000163 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 754093000164 putative catalytic residues [active] 754093000165 putative nucleotide binding site [chemical binding]; other site 754093000166 putative aspartate binding site [chemical binding]; other site 754093000167 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 754093000168 dimer interface [polypeptide binding]; other site 754093000169 putative threonine allosteric regulatory site; other site 754093000170 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 754093000171 putative threonine allosteric regulatory site; other site 754093000172 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 754093000173 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 754093000174 homoserine kinase; Region: thrB; TIGR00191 754093000175 Protein of unknown function; Region: YhfT; pfam10797 754093000176 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 754093000177 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 754093000178 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 754093000179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093000180 catalytic residue [active] 754093000181 hypothetical protein; Validated; Region: PRK02101 754093000182 transaldolase-like protein; Provisional; Region: PTZ00411 754093000183 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 754093000184 active site 754093000185 dimer interface [polypeptide binding]; other site 754093000186 catalytic residue [active] 754093000187 hypothetical protein; Provisional; Region: PRK10659 754093000188 hypothetical protein; Provisional; Region: PRK10236 754093000189 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 754093000190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 754093000191 hypothetical protein; Provisional; Region: PRK10154 754093000192 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 754093000193 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 754093000194 nucleotide binding site [chemical binding]; other site 754093000195 NEF interaction site [polypeptide binding]; other site 754093000196 SBD interface [polypeptide binding]; other site 754093000197 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 754093000198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093000199 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093000200 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093000201 hypothetical protein; Provisional; Region: PRK05248 754093000202 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 754093000203 spermidine synthase; Provisional; Region: PRK00811 754093000204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093000205 S-adenosylmethionine binding site [chemical binding]; other site 754093000206 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 754093000207 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 754093000208 active site clefts [active] 754093000209 zinc binding site [ion binding]; other site 754093000210 dimer interface [polypeptide binding]; other site 754093000211 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 754093000212 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 754093000213 Walker A/P-loop; other site 754093000214 ATP binding site [chemical binding]; other site 754093000215 Q-loop/lid; other site 754093000216 ABC transporter signature motif; other site 754093000217 Walker B; other site 754093000218 D-loop; other site 754093000219 H-loop/switch region; other site 754093000220 inner membrane transport permease; Provisional; Region: PRK15066 754093000221 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 754093000222 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 754093000223 active pocket/dimerization site; other site 754093000224 active site 754093000225 phosphorylation site [posttranslational modification] 754093000226 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 754093000227 tetramerization interface [polypeptide binding]; other site 754093000228 active site 754093000229 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 754093000230 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 754093000231 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 754093000232 active site 754093000233 Riboflavin kinase; Region: Flavokinase; smart00904 754093000234 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 754093000235 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 754093000236 HIGH motif; other site 754093000237 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 754093000238 active site 754093000239 KMSKS motif; other site 754093000240 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 754093000241 tRNA binding surface [nucleotide binding]; other site 754093000242 anticodon binding site; other site 754093000243 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 754093000244 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 754093000245 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 754093000246 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 754093000247 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 754093000248 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 754093000249 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 754093000250 active site 754093000251 tetramer interface [polypeptide binding]; other site 754093000252 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 754093000253 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 754093000254 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 754093000255 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 754093000256 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 754093000257 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 754093000258 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 754093000259 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 754093000260 ATP-grasp domain; Region: ATP-grasp_4; cl17255 754093000261 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 754093000262 IMP binding site; other site 754093000263 dimer interface [polypeptide binding]; other site 754093000264 interdomain contacts; other site 754093000265 partial ornithine binding site; other site 754093000266 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 754093000267 carnitine operon protein CaiE; Provisional; Region: PRK13627 754093000268 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 754093000269 putative trimer interface [polypeptide binding]; other site 754093000270 putative CoA binding site [chemical binding]; other site 754093000271 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 754093000272 CoA-transferase family III; Region: CoA_transf_3; pfam02515 754093000273 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 754093000274 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 754093000275 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 754093000276 Ligand binding site [chemical binding]; other site 754093000277 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 754093000278 putative oxidoreductase FixC; Provisional; Region: PRK10157 754093000279 putative oxidoreductase FixC; Provisional; Region: PRK10157 754093000280 ferredoxin-like protein FixX; Provisional; Region: PRK15449 754093000281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093000282 putative substrate translocation pore; other site 754093000283 cation transport protein; Region: 2A0119; TIGR00898 754093000284 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 754093000285 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 754093000286 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 754093000287 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 754093000288 TrkA-N domain; Region: TrkA_N; pfam02254 754093000289 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 754093000290 CcdB protein; Region: CcdB; pfam01845 754093000291 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 754093000292 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 754093000293 active site 754093000294 metal binding site [ion binding]; metal-binding site 754093000295 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 754093000296 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 754093000297 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 754093000298 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 754093000299 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 754093000300 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 754093000301 SurA N-terminal domain; Region: SurA_N; pfam09312 754093000302 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 754093000303 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 754093000304 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 754093000305 OstA-like protein; Region: OstA; pfam03968 754093000306 Organic solvent tolerance protein; Region: OstA_C; pfam04453 754093000307 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 754093000308 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 754093000309 putative metal binding site [ion binding]; other site 754093000310 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 754093000311 HSP70 interaction site [polypeptide binding]; other site 754093000312 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 754093000313 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 754093000314 active site 754093000315 ATP-dependent helicase HepA; Validated; Region: PRK04914 754093000316 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754093000317 ATP binding site [chemical binding]; other site 754093000318 putative Mg++ binding site [ion binding]; other site 754093000319 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754093000320 nucleotide binding region [chemical binding]; other site 754093000321 ATP-binding site [chemical binding]; other site 754093000322 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 754093000323 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093000324 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093000325 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093000326 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093000327 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 754093000328 catalytic site [active] 754093000329 L-arabinose isomerase; Provisional; Region: PRK02929 754093000330 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 754093000331 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 754093000332 trimer interface [polypeptide binding]; other site 754093000333 putative substrate binding site [chemical binding]; other site 754093000334 putative metal binding site [ion binding]; other site 754093000335 ribulokinase; Provisional; Region: PRK04123 754093000336 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 754093000337 N- and C-terminal domain interface [polypeptide binding]; other site 754093000338 active site 754093000339 MgATP binding site [chemical binding]; other site 754093000340 catalytic site [active] 754093000341 metal binding site [ion binding]; metal-binding site 754093000342 carbohydrate binding site [chemical binding]; other site 754093000343 homodimer interface [polypeptide binding]; other site 754093000344 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 754093000345 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093000346 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 754093000347 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 754093000348 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 754093000349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093000350 dimer interface [polypeptide binding]; other site 754093000351 conserved gate region; other site 754093000352 putative PBP binding loops; other site 754093000353 ABC-ATPase subunit interface; other site 754093000354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093000355 dimer interface [polypeptide binding]; other site 754093000356 conserved gate region; other site 754093000357 putative PBP binding loops; other site 754093000358 ABC-ATPase subunit interface; other site 754093000359 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093000360 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 754093000361 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 754093000362 substrate binding site [chemical binding]; other site 754093000363 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 754093000364 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 754093000365 substrate binding site [chemical binding]; other site 754093000366 ligand binding site [chemical binding]; other site 754093000367 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 754093000368 tartrate dehydrogenase; Region: TTC; TIGR02089 754093000369 2-isopropylmalate synthase; Validated; Region: PRK00915 754093000370 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 754093000371 active site 754093000372 catalytic residues [active] 754093000373 metal binding site [ion binding]; metal-binding site 754093000374 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 754093000375 leu operon leader peptide; Provisional; Region: PRK09925 754093000376 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093000377 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093000378 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093000379 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 754093000380 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754093000381 DNA binding site [nucleotide binding] 754093000382 domain linker motif; other site 754093000383 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 754093000384 dimerization interface [polypeptide binding]; other site 754093000385 ligand binding site [chemical binding]; other site 754093000386 cell division protein FtsL; Provisional; Region: PRK10772 754093000387 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 754093000388 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 754093000389 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 754093000390 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 754093000391 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 754093000392 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754093000393 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 754093000394 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 754093000395 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 754093000396 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754093000397 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 754093000398 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 754093000399 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 754093000400 Mg++ binding site [ion binding]; other site 754093000401 putative catalytic motif [active] 754093000402 putative substrate binding site [chemical binding]; other site 754093000403 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 754093000404 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754093000405 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 754093000406 cell division protein FtsW; Provisional; Region: PRK10774 754093000407 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 754093000408 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 754093000409 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754093000410 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 754093000411 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 754093000412 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 754093000413 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 754093000414 cell division protein FtsQ; Provisional; Region: PRK10775 754093000415 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 754093000416 Cell division protein FtsQ; Region: FtsQ; pfam03799 754093000417 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 754093000418 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 754093000419 Cell division protein FtsA; Region: FtsA; pfam14450 754093000420 cell division protein FtsZ; Validated; Region: PRK09330 754093000421 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 754093000422 nucleotide binding site [chemical binding]; other site 754093000423 SulA interaction site; other site 754093000424 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 754093000425 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 754093000426 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 754093000427 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 754093000428 SEC-C motif; Region: SEC-C; pfam02810 754093000429 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 754093000430 active site 754093000431 8-oxo-dGMP binding site [chemical binding]; other site 754093000432 nudix motif; other site 754093000433 metal binding site [ion binding]; metal-binding site 754093000434 DNA gyrase inhibitor; Reviewed; Region: PRK00418 754093000435 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 754093000436 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 754093000437 CoA-binding site [chemical binding]; other site 754093000438 ATP-binding [chemical binding]; other site 754093000439 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 754093000440 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 754093000441 active site 754093000442 type IV pilin biogenesis protein; Provisional; Region: PRK10573 754093000443 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 754093000444 hypothetical protein; Provisional; Region: PRK10436 754093000445 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 754093000446 Walker A motif; other site 754093000447 ATP binding site [chemical binding]; other site 754093000448 Walker B motif; other site 754093000449 putative major pilin subunit; Provisional; Region: PRK10574 754093000450 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 754093000451 Pilin (bacterial filament); Region: Pilin; pfam00114 754093000452 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 754093000453 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 754093000454 amidase catalytic site [active] 754093000455 Zn binding residues [ion binding]; other site 754093000456 substrate binding site [chemical binding]; other site 754093000457 aromatic amino acid transporter; Provisional; Region: PRK10238 754093000458 Transcriptional regulators [Transcription]; Region: FadR; COG2186 754093000459 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754093000460 DNA-binding site [nucleotide binding]; DNA binding site 754093000461 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 754093000462 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 754093000463 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 754093000464 dimer interface [polypeptide binding]; other site 754093000465 TPP-binding site [chemical binding]; other site 754093000466 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 754093000467 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 754093000468 E3 interaction surface; other site 754093000469 lipoyl attachment site [posttranslational modification]; other site 754093000470 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 754093000471 E3 interaction surface; other site 754093000472 lipoyl attachment site [posttranslational modification]; other site 754093000473 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 754093000474 E3 interaction surface; other site 754093000475 lipoyl attachment site [posttranslational modification]; other site 754093000476 e3 binding domain; Region: E3_binding; pfam02817 754093000477 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 754093000478 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 754093000479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093000480 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093000481 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093000482 Fimbrial protein; Region: Fimbrial; cl01416 754093000483 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 754093000484 oligomerization interface [polypeptide binding]; other site 754093000485 active site 754093000486 metal binding site [ion binding]; metal-binding site 754093000487 pantoate--beta-alanine ligase; Region: panC; TIGR00018 754093000488 Pantoate-beta-alanine ligase; Region: PanC; cd00560 754093000489 active site 754093000490 ATP-binding site [chemical binding]; other site 754093000491 pantoate-binding site; other site 754093000492 HXXH motif; other site 754093000493 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093000494 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093000495 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093000496 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 754093000497 catalytic center binding site [active] 754093000498 ATP binding site [chemical binding]; other site 754093000499 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 754093000500 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 754093000501 active site 754093000502 NTP binding site [chemical binding]; other site 754093000503 metal binding triad [ion binding]; metal-binding site 754093000504 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 754093000505 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 754093000506 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 754093000507 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 754093000508 active site 754093000509 nucleotide binding site [chemical binding]; other site 754093000510 HIGH motif; other site 754093000511 KMSKS motif; other site 754093000512 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 754093000513 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 754093000514 2'-5' RNA ligase; Provisional; Region: PRK15124 754093000515 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 754093000516 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 754093000517 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 754093000518 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 754093000519 N-terminal plug; other site 754093000520 ligand-binding site [chemical binding]; other site 754093000521 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 754093000522 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754093000523 inhibitor-cofactor binding pocket; inhibition site 754093000524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093000525 catalytic residue [active] 754093000526 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 754093000527 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 754093000528 Cl- selectivity filter; other site 754093000529 Cl- binding residues [ion binding]; other site 754093000530 pore gating glutamate residue; other site 754093000531 dimer interface [polypeptide binding]; other site 754093000532 H+/Cl- coupling transport residue; other site 754093000533 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 754093000534 hypothetical protein; Provisional; Region: PRK10578 754093000535 UPF0126 domain; Region: UPF0126; pfam03458 754093000536 UPF0126 domain; Region: UPF0126; pfam03458 754093000537 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 754093000538 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 754093000539 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 754093000540 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 754093000541 Zn2+ binding site [ion binding]; other site 754093000542 Mg2+ binding site [ion binding]; other site 754093000543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093000544 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093000545 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093000546 serine endoprotease; Provisional; Region: PRK10942 754093000547 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 754093000548 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754093000549 protein binding site [polypeptide binding]; other site 754093000550 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754093000551 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 754093000552 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 754093000553 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 754093000554 hypothetical protein; Provisional; Region: PRK13677 754093000555 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 754093000556 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 754093000557 trimer interface [polypeptide binding]; other site 754093000558 active site 754093000559 substrate binding site [chemical binding]; other site 754093000560 CoA binding site [chemical binding]; other site 754093000561 PII uridylyl-transferase; Provisional; Region: PRK05007 754093000562 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 754093000563 metal binding triad; other site 754093000564 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 754093000565 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 754093000566 Zn2+ binding site [ion binding]; other site 754093000567 Mg2+ binding site [ion binding]; other site 754093000568 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 754093000569 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 754093000570 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 754093000571 active site 754093000572 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 754093000573 putative nucleotide binding site [chemical binding]; other site 754093000574 uridine monophosphate binding site [chemical binding]; other site 754093000575 homohexameric interface [polypeptide binding]; other site 754093000576 ribosome recycling factor; Reviewed; Region: frr; PRK00083 754093000577 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 754093000578 hinge region; other site 754093000579 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 754093000580 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 754093000581 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 754093000582 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 754093000583 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 754093000584 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 754093000585 catalytic residue [active] 754093000586 putative FPP diphosphate binding site; other site 754093000587 putative FPP binding hydrophobic cleft; other site 754093000588 dimer interface [polypeptide binding]; other site 754093000589 putative IPP diphosphate binding site; other site 754093000590 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 754093000591 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 754093000592 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 754093000593 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 754093000594 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 754093000595 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 754093000596 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 754093000597 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 754093000598 Surface antigen; Region: Bac_surface_Ag; pfam01103 754093000599 periplasmic chaperone; Provisional; Region: PRK10780 754093000600 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 754093000601 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 754093000602 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 754093000603 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 754093000604 trimer interface [polypeptide binding]; other site 754093000605 active site 754093000606 UDP-GlcNAc binding site [chemical binding]; other site 754093000607 lipid binding site [chemical binding]; lipid-binding site 754093000608 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 754093000609 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 754093000610 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 754093000611 active site 754093000612 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 754093000613 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 754093000614 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 754093000615 RNA/DNA hybrid binding site [nucleotide binding]; other site 754093000616 active site 754093000617 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 754093000618 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 754093000619 putative active site [active] 754093000620 putative PHP Thumb interface [polypeptide binding]; other site 754093000621 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 754093000622 generic binding surface II; other site 754093000623 generic binding surface I; other site 754093000624 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 754093000625 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 754093000626 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 754093000627 catalytic residue [active] 754093000628 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 754093000629 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 754093000630 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754093000631 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 754093000632 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 754093000633 Ligand Binding Site [chemical binding]; other site 754093000634 TilS substrate binding domain; Region: TilS; pfam09179 754093000635 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 754093000636 Rho-binding antiterminator; Provisional; Region: PRK11625 754093000637 hypothetical protein; Provisional; Region: PRK04964 754093000638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 754093000639 hypothetical protein; Provisional; Region: PRK09256 754093000640 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 754093000641 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 754093000642 NlpE N-terminal domain; Region: NlpE; pfam04170 754093000643 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 754093000644 homodimer interaction site [polypeptide binding]; other site 754093000645 cofactor binding site; other site 754093000646 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 754093000647 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 754093000648 lipoprotein, YaeC family; Region: TIGR00363 754093000649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093000650 dimer interface [polypeptide binding]; other site 754093000651 conserved gate region; other site 754093000652 ABC-ATPase subunit interface; other site 754093000653 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 754093000654 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 754093000655 Walker A/P-loop; other site 754093000656 ATP binding site [chemical binding]; other site 754093000657 Q-loop/lid; other site 754093000658 ABC transporter signature motif; other site 754093000659 Walker B; other site 754093000660 D-loop; other site 754093000661 H-loop/switch region; other site 754093000662 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 754093000663 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754093000664 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754093000665 active site 754093000666 catalytic tetrad [active] 754093000667 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754093000668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093000669 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 754093000670 putative effector binding pocket; other site 754093000671 dimerization interface [polypeptide binding]; other site 754093000672 hypothetical protein; Provisional; Region: PRK05421 754093000673 putative catalytic site [active] 754093000674 putative metal binding site [ion binding]; other site 754093000675 putative phosphate binding site [ion binding]; other site 754093000676 putative catalytic site [active] 754093000677 putative phosphate binding site [ion binding]; other site 754093000678 putative metal binding site [ion binding]; other site 754093000679 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 754093000680 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754093000681 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754093000682 catalytic residue [active] 754093000683 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 754093000684 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 754093000685 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 754093000686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093000687 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 754093000688 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 754093000689 active site 754093000690 catalytic site [active] 754093000691 substrate binding site [chemical binding]; other site 754093000692 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093000693 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 754093000694 C-lysozyme inhibitor; Provisional; Region: PRK09993 754093000695 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 754093000696 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 754093000697 active site 754093000698 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 754093000699 RelB antitoxin; Region: RelB; pfam04221 754093000700 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 754093000701 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093000702 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093000703 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093000704 hypothetical protein; Provisional; Region: PRK09936 754093000705 hypothetical protein; Provisional; Region: PRK09936 754093000706 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754093000707 TPR motif; other site 754093000708 TPR repeat; Region: TPR_11; pfam13414 754093000709 binding surface 754093000710 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 754093000711 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 754093000712 active site 754093000713 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 754093000714 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 754093000715 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 754093000716 homodimer interface [polypeptide binding]; other site 754093000717 nucleotide binding site [chemical binding]; other site 754093000718 nucleotide binding site [chemical binding]; other site 754093000719 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 754093000720 ATP-grasp domain; Region: ATP-grasp; pfam02222 754093000721 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 754093000722 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 754093000723 putative active site [active] 754093000724 putative metal binding site [ion binding]; other site 754093000725 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 754093000726 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 754093000727 active site 754093000728 HIGH motif; other site 754093000729 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 754093000730 KMSKS motif; other site 754093000731 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 754093000732 tRNA binding surface [nucleotide binding]; other site 754093000733 anticodon binding site; other site 754093000734 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 754093000735 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 754093000736 Ligand Binding Site [chemical binding]; other site 754093000737 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093000738 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 754093000739 periplasmic folding chaperone; Provisional; Region: PRK10788 754093000740 SurA N-terminal domain; Region: SurA_N_3; cl07813 754093000741 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 754093000742 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 754093000743 Found in ATP-dependent protease La (LON); Region: LON; smart00464 754093000744 Found in ATP-dependent protease La (LON); Region: LON; smart00464 754093000745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754093000746 Walker A motif; other site 754093000747 ATP binding site [chemical binding]; other site 754093000748 Walker B motif; other site 754093000749 arginine finger; other site 754093000750 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 754093000751 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 754093000752 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 754093000753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754093000754 Walker A motif; other site 754093000755 ATP binding site [chemical binding]; other site 754093000756 Walker B motif; other site 754093000757 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 754093000758 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 754093000759 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 754093000760 oligomer interface [polypeptide binding]; other site 754093000761 active site residues [active] 754093000762 trigger factor; Provisional; Region: tig; PRK01490 754093000763 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 754093000764 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 754093000765 transcriptional regulator BolA; Provisional; Region: PRK11628 754093000766 hypothetical protein; Provisional; Region: PRK11627 754093000767 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 754093000768 muropeptide transporter; Reviewed; Region: ampG; PRK11902 754093000769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093000770 putative substrate translocation pore; other site 754093000771 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093000772 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093000773 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093000774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093000775 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754093000776 putative substrate translocation pore; other site 754093000777 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 754093000778 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 754093000779 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 754093000780 Ligand Binding Site [chemical binding]; other site 754093000781 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 754093000782 active site residue [active] 754093000783 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 754093000784 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 754093000785 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 754093000786 substrate binding pocket [chemical binding]; other site 754093000787 chain length determination region; other site 754093000788 substrate-Mg2+ binding site; other site 754093000789 catalytic residues [active] 754093000790 aspartate-rich region 1; other site 754093000791 active site lid residues [active] 754093000792 aspartate-rich region 2; other site 754093000793 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 754093000794 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 754093000795 TPP-binding site; other site 754093000796 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 754093000797 PYR/PP interface [polypeptide binding]; other site 754093000798 dimer interface [polypeptide binding]; other site 754093000799 TPP binding site [chemical binding]; other site 754093000800 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 754093000801 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754093000802 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754093000803 active site 754093000804 catalytic tetrad [active] 754093000805 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 754093000806 tetramer interfaces [polypeptide binding]; other site 754093000807 binuclear metal-binding site [ion binding]; other site 754093000808 thiamine monophosphate kinase; Provisional; Region: PRK05731 754093000809 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 754093000810 ATP binding site [chemical binding]; other site 754093000811 dimerization interface [polypeptide binding]; other site 754093000812 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 754093000813 putative RNA binding site [nucleotide binding]; other site 754093000814 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 754093000815 homopentamer interface [polypeptide binding]; other site 754093000816 active site 754093000817 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 754093000818 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 754093000819 catalytic motif [active] 754093000820 Zn binding site [ion binding]; other site 754093000821 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 754093000822 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 754093000823 ATP cone domain; Region: ATP-cone; pfam03477 754093000824 hypothetical protein; Provisional; Region: PRK11530 754093000825 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 754093000826 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 754093000827 active site 754093000828 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 754093000829 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 754093000830 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 754093000831 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 754093000832 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 754093000833 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 754093000834 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 754093000835 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 754093000836 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 754093000837 Protein of unknown function, DUF479; Region: DUF479; cl01203 754093000838 putative proline-specific permease; Provisional; Region: proY; PRK10580 754093000839 Spore germination protein; Region: Spore_permease; cl17796 754093000840 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 754093000841 transcriptional regulator PhoB; Provisional; Region: PRK10161 754093000842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093000843 active site 754093000844 phosphorylation site [posttranslational modification] 754093000845 intermolecular recognition site; other site 754093000846 dimerization interface [polypeptide binding]; other site 754093000847 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754093000848 DNA binding site [nucleotide binding] 754093000849 exonuclease subunit SbcC; Provisional; Region: PRK10246 754093000850 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093000851 Walker A/P-loop; other site 754093000852 ATP binding site [chemical binding]; other site 754093000853 Q-loop/lid; other site 754093000854 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093000855 ABC transporter signature motif; other site 754093000856 Walker B; other site 754093000857 D-loop; other site 754093000858 H-loop/switch region; other site 754093000859 fructokinase; Reviewed; Region: PRK09557 754093000860 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 754093000861 nucleotide binding site [chemical binding]; other site 754093000862 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 754093000863 hypothetical protein; Provisional; Region: PRK10579 754093000864 hypothetical protein; Provisional; Region: PRK10481 754093000865 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 754093000866 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 754093000867 ADP binding site [chemical binding]; other site 754093000868 magnesium binding site [ion binding]; other site 754093000869 putative shikimate binding site; other site 754093000870 hypothetical protein; Validated; Region: PRK00124 754093000871 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 754093000872 pyrroline-5-carboxylate reductase; Region: PLN02688 754093000873 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 754093000874 MASE2 domain; Region: MASE2; pfam05230 754093000875 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754093000876 metal binding site [ion binding]; metal-binding site 754093000877 active site 754093000878 I-site; other site 754093000879 psiF repeat; Region: PsiF_repeat; pfam07769 754093000880 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 754093000881 dimer interface [polypeptide binding]; other site 754093000882 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 754093000883 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 754093000884 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 754093000885 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 754093000886 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 754093000887 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 754093000888 microcin B17 transporter; Reviewed; Region: PRK11098 754093000889 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 754093000890 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 754093000891 Transcriptional regulator; Region: Rrf2; cl17282 754093000892 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093000893 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093000894 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093000895 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093000896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093000897 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093000898 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093000899 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 754093000900 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093000901 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754093000902 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 754093000903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093000904 Walker A/P-loop; other site 754093000905 ATP binding site [chemical binding]; other site 754093000906 Q-loop/lid; other site 754093000907 ABC transporter signature motif; other site 754093000908 Walker B; other site 754093000909 D-loop; other site 754093000910 H-loop/switch region; other site 754093000911 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 754093000912 Nitrogen regulatory protein P-II; Region: P-II; smart00938 754093000913 ammonium transporter; Provisional; Region: PRK10666 754093000914 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 754093000915 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 754093000916 Uncharacterized conserved protein [Function unknown]; Region: COG5507 754093000917 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 754093000918 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 754093000919 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754093000920 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 754093000921 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 754093000922 Bacterial transcriptional regulator; Region: IclR; pfam01614 754093000923 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 754093000924 ureidoglycolate hydrolase; Provisional; Region: PRK03606 754093000925 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 754093000926 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093000927 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754093000928 dimerization interface [polypeptide binding]; other site 754093000929 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 754093000930 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 754093000931 active site residue [active] 754093000932 Winged helix-turn helix; Region: HTH_29; pfam13551 754093000933 Helix-turn-helix domain; Region: HTH_28; pfam13518 754093000934 FtsX-like permease family; Region: FtsX; pfam02687 754093000935 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 754093000936 FtsX-like permease family; Region: FtsX; pfam02687 754093000937 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 754093000938 oxidoreductase; Provisional; Region: PRK08017 754093000939 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 754093000940 NADP binding site [chemical binding]; other site 754093000941 active site 754093000942 steroid binding site; other site 754093000943 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 754093000944 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 754093000945 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 754093000946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093000947 Walker A/P-loop; other site 754093000948 ATP binding site [chemical binding]; other site 754093000949 Q-loop/lid; other site 754093000950 ABC transporter signature motif; other site 754093000951 Walker B; other site 754093000952 D-loop; other site 754093000953 H-loop/switch region; other site 754093000954 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 754093000955 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 754093000956 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 754093000957 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 754093000958 HlyD family secretion protein; Region: HlyD_3; pfam13437 754093000959 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 754093000960 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 754093000961 Family description; Region: VCBS; pfam13517 754093000962 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 754093000963 Family description; Region: VCBS; pfam13517 754093000964 amino acid transporter; Region: 2A0306; TIGR00909 754093000965 glutaminase; Reviewed; Region: PRK12356 754093000966 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 754093000967 copper exporting ATPase; Provisional; Region: copA; PRK10671 754093000968 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 754093000969 metal-binding site [ion binding] 754093000970 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 754093000971 metal-binding site [ion binding] 754093000972 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 754093000973 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093000974 motif II; other site 754093000975 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 754093000976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754093000977 sequence-specific DNA binding site [nucleotide binding]; other site 754093000978 salt bridge; other site 754093000979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 754093000980 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 754093000981 putative deacylase active site [active] 754093000982 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 754093000983 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 754093000984 active site 754093000985 metal binding site [ion binding]; metal-binding site 754093000986 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 754093000987 inosine/guanosine kinase; Provisional; Region: PRK15074 754093000988 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754093000989 ferrochelatase; Region: hemH; TIGR00109 754093000990 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 754093000991 C-terminal domain interface [polypeptide binding]; other site 754093000992 active site 754093000993 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 754093000994 active site 754093000995 N-terminal domain interface [polypeptide binding]; other site 754093000996 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 754093000997 RecR protein; Region: RecR; pfam02132 754093000998 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 754093000999 putative active site [active] 754093001000 putative metal-binding site [ion binding]; other site 754093001001 tetramer interface [polypeptide binding]; other site 754093001002 hypothetical protein; Validated; Region: PRK00153 754093001003 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 754093001004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754093001005 Walker A motif; other site 754093001006 ATP binding site [chemical binding]; other site 754093001007 Walker B motif; other site 754093001008 DNA polymerase III subunit delta'; Validated; Region: PRK08485 754093001009 arginine finger; other site 754093001010 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 754093001011 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 754093001012 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 754093001013 hypothetical protein; Provisional; Region: PRK10527 754093001014 primosomal replication protein N''; Provisional; Region: PRK10093 754093001015 hypothetical protein; Provisional; Region: PRK11038 754093001016 hypothetical protein; Provisional; Region: PRK11281 754093001017 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 754093001018 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 754093001019 Mechanosensitive ion channel; Region: MS_channel; pfam00924 754093001020 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 754093001021 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754093001022 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 754093001023 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 754093001024 Protein export membrane protein; Region: SecD_SecF; cl14618 754093001025 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 754093001026 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 754093001027 gene expression modulator; Provisional; Region: PRK10945 754093001028 maltose O-acetyltransferase; Provisional; Region: PRK10092 754093001029 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 754093001030 active site 754093001031 substrate binding site [chemical binding]; other site 754093001032 trimer interface [polypeptide binding]; other site 754093001033 CoA binding site [chemical binding]; other site 754093001034 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 754093001035 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 754093001036 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093001037 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 754093001038 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 754093001039 putative catalytic cysteine [active] 754093001040 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 754093001041 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 754093001042 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754093001043 active site 754093001044 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 754093001045 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 754093001046 metal binding site [ion binding]; metal-binding site 754093001047 dimer interface [polypeptide binding]; other site 754093001048 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 754093001049 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 754093001050 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 754093001051 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 754093001052 active site 754093001053 DNA polymerase IV; Validated; Region: PRK02406 754093001054 DNA binding site [nucleotide binding] 754093001055 hypothetical protein; Validated; Region: PRK06778 754093001056 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 754093001057 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 754093001058 ligand binding site [chemical binding]; other site 754093001059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093001060 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093001061 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093001062 hypothetical protein; Provisional; Region: PRK10250 754093001063 Integrase core domain; Region: rve_3; pfam13683 754093001064 Transposase; Region: HTH_Tnp_1; cl17663 754093001065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093001066 Autotransporter beta-domain; Region: Autotransporter; pfam03797 754093001067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093001068 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093001069 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093001070 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 754093001071 dimer interface [polypeptide binding]; other site 754093001072 active site 754093001073 Schiff base residues; other site 754093001074 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 754093001075 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 754093001076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 754093001077 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 754093001078 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 754093001079 Walker A/P-loop; other site 754093001080 ATP binding site [chemical binding]; other site 754093001081 Q-loop/lid; other site 754093001082 ABC transporter signature motif; other site 754093001083 Walker B; other site 754093001084 D-loop; other site 754093001085 H-loop/switch region; other site 754093001086 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 754093001087 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754093001088 substrate binding pocket [chemical binding]; other site 754093001089 membrane-bound complex binding site; other site 754093001090 hinge residues; other site 754093001091 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754093001092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093001093 active site 754093001094 phosphorylation site [posttranslational modification] 754093001095 intermolecular recognition site; other site 754093001096 dimerization interface [polypeptide binding]; other site 754093001097 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754093001098 DNA binding residues [nucleotide binding] 754093001099 dimerization interface [polypeptide binding]; other site 754093001100 Transposase; Region: HTH_Tnp_1; cl17663 754093001101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093001102 Hok/gef family; Region: HOK_GEF; pfam01848 754093001103 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 754093001104 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 754093001105 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 754093001106 LPS O-antigen length regulator; Provisional; Region: PRK10381 754093001107 Chain length determinant protein; Region: Wzz; pfam02706 754093001108 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 754093001109 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 754093001110 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 754093001111 Walker A/P-loop; other site 754093001112 ATP binding site [chemical binding]; other site 754093001113 Q-loop/lid; other site 754093001114 ABC transporter signature motif; other site 754093001115 Walker B; other site 754093001116 D-loop; other site 754093001117 H-loop/switch region; other site 754093001118 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 754093001119 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754093001120 ABC-ATPase subunit interface; other site 754093001121 dimer interface [polypeptide binding]; other site 754093001122 putative PBP binding regions; other site 754093001123 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 754093001124 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 754093001125 siderophore binding site; other site 754093001126 isochorismate synthase EntC; Provisional; Region: PRK15016 754093001127 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 754093001128 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 754093001129 hydrophobic substrate binding pocket; other site 754093001130 Isochorismatase family; Region: Isochorismatase; pfam00857 754093001131 active site 754093001132 conserved cis-peptide bond; other site 754093001133 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 754093001134 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 754093001135 CoenzymeA binding site [chemical binding]; other site 754093001136 subunit interaction site [polypeptide binding]; other site 754093001137 PHB binding site; other site 754093001138 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 754093001139 Uncharacterized small protein [Function unknown]; Region: COG2879 754093001140 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 754093001141 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 754093001142 putative active site [active] 754093001143 metal binding site [ion binding]; metal-binding site 754093001144 methionine aminotransferase; Validated; Region: PRK09082 754093001145 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 754093001146 ParB-like nuclease domain; Region: ParBc; pfam02195 754093001147 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 754093001148 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 754093001149 dimer interface [polypeptide binding]; other site 754093001150 decamer (pentamer of dimers) interface [polypeptide binding]; other site 754093001151 catalytic triad [active] 754093001152 peroxidatic and resolving cysteines [active] 754093001153 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 754093001154 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 754093001155 catalytic residue [active] 754093001156 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 754093001157 catalytic residues [active] 754093001158 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754093001159 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754093001160 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 754093001161 Ligand Binding Site [chemical binding]; other site 754093001162 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 754093001163 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 754093001164 DNA-binding site [nucleotide binding]; DNA binding site 754093001165 RNA-binding motif; other site 754093001166 chromosome condensation membrane protein; Provisional; Region: PRK14196 754093001167 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 754093001168 lipoyl synthase; Provisional; Region: PRK05481 754093001169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754093001170 FeS/SAM binding site; other site 754093001171 hypothetical protein; Provisional; Region: PRK04998 754093001172 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 754093001173 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 754093001174 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 754093001175 rare lipoprotein A; Provisional; Region: PRK10672 754093001176 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 754093001177 Sporulation related domain; Region: SPOR; pfam05036 754093001178 penicillin-binding protein 2; Provisional; Region: PRK10795 754093001179 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 754093001180 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 754093001181 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 754093001182 ribosome-associated protein; Provisional; Region: PRK11538 754093001183 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 754093001184 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754093001185 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 754093001186 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 754093001187 active site 754093001188 (T/H)XGH motif; other site 754093001189 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 754093001190 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 754093001191 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 754093001192 hypothetical protein; Provisional; Region: PRK11032 754093001193 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 754093001194 Sel1-like repeats; Region: SEL1; smart00671 754093001195 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 754093001196 Sel1-like repeats; Region: SEL1; smart00671 754093001197 Sel1-like repeats; Region: SEL1; smart00671 754093001198 Sel1-like repeats; Region: SEL1; smart00671 754093001199 Sel1-like repeats; Region: SEL1; smart00671 754093001200 Sel1-like repeats; Region: SEL1; smart00671 754093001201 Sel1-like repeats; Region: SEL1; smart00671 754093001202 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093001203 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 754093001204 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 754093001205 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 754093001206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093001207 Walker A/P-loop; other site 754093001208 ATP binding site [chemical binding]; other site 754093001209 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754093001210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093001211 dimer interface [polypeptide binding]; other site 754093001212 conserved gate region; other site 754093001213 putative PBP binding loops; other site 754093001214 ABC-ATPase subunit interface; other site 754093001215 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 754093001216 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754093001217 substrate binding pocket [chemical binding]; other site 754093001218 membrane-bound complex binding site; other site 754093001219 hinge residues; other site 754093001220 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 754093001221 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 754093001222 putative active site [active] 754093001223 catalytic triad [active] 754093001224 putative dimer interface [polypeptide binding]; other site 754093001225 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 754093001226 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 754093001227 Transporter associated domain; Region: CorC_HlyC; smart01091 754093001228 metal-binding heat shock protein; Provisional; Region: PRK00016 754093001229 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 754093001230 PhoH-like protein; Region: PhoH; pfam02562 754093001231 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 754093001232 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 754093001233 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754093001234 FeS/SAM binding site; other site 754093001235 TRAM domain; Region: TRAM; pfam01938 754093001236 asparagine synthetase B; Provisional; Region: asnB; PRK09431 754093001237 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 754093001238 active site 754093001239 dimer interface [polypeptide binding]; other site 754093001240 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 754093001241 Ligand Binding Site [chemical binding]; other site 754093001242 Molecular Tunnel; other site 754093001243 UMP phosphatase; Provisional; Region: PRK10444 754093001244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093001245 active site 754093001246 motif I; other site 754093001247 motif II; other site 754093001248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093001249 MarR family; Region: MarR; pfam01047 754093001250 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 754093001251 ROK family; Region: ROK; pfam00480 754093001252 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 754093001253 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 754093001254 active site 754093001255 dimer interface [polypeptide binding]; other site 754093001256 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 754093001257 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 754093001258 active site 754093001259 trimer interface [polypeptide binding]; other site 754093001260 allosteric site; other site 754093001261 active site lid [active] 754093001262 hexamer (dimer of trimers) interface [polypeptide binding]; other site 754093001263 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 754093001264 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 754093001265 active site 754093001266 HIGH motif; other site 754093001267 nucleotide binding site [chemical binding]; other site 754093001268 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 754093001269 KMSKS motif; other site 754093001270 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 754093001271 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093001272 outer membrane porin, OprD family; Region: OprD; pfam03573 754093001273 YbfN-like lipoprotein; Region: YbfN; pfam13982 754093001274 YbfN-like lipoprotein; Region: YbfN; pfam13982 754093001275 ferric uptake regulator; Provisional; Region: fur; PRK09462 754093001276 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 754093001277 metal binding site 2 [ion binding]; metal-binding site 754093001278 putative DNA binding helix; other site 754093001279 metal binding site 1 [ion binding]; metal-binding site 754093001280 dimer interface [polypeptide binding]; other site 754093001281 structural Zn2+ binding site [ion binding]; other site 754093001282 LexA regulated protein; Provisional; Region: PRK11675 754093001283 acyl-CoA esterase; Provisional; Region: PRK10673 754093001284 PGAP1-like protein; Region: PGAP1; pfam07819 754093001285 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 754093001286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093001287 active site 754093001288 phosphorylation site [posttranslational modification] 754093001289 intermolecular recognition site; other site 754093001290 dimerization interface [polypeptide binding]; other site 754093001291 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754093001292 DNA binding site [nucleotide binding] 754093001293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093001294 Mg2+ binding site [ion binding]; other site 754093001295 G-X-G motif; other site 754093001296 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 754093001297 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 754093001298 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 754093001299 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 754093001300 putative lyase; Provisional; Region: PRK09687 754093001301 hypothetical protein; Provisional; Region: PRK10167 754093001302 Uncharacterized conserved protein [Function unknown]; Region: COG3272 754093001303 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 754093001304 DNA photolyase; Region: DNA_photolyase; pfam00875 754093001305 POT family; Region: PTR2; cl17359 754093001306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093001307 putative substrate translocation pore; other site 754093001308 Uncharacterized conserved protein [Function unknown]; Region: COG0327 754093001309 metal-binding protein; Provisional; Region: PRK10799 754093001310 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 754093001311 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 754093001312 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 754093001313 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 754093001314 putative active site [active] 754093001315 endonuclease VIII; Provisional; Region: PRK10445 754093001316 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 754093001317 DNA binding site [nucleotide binding] 754093001318 catalytic residue [active] 754093001319 putative catalytic residues [active] 754093001320 H2TH interface [polypeptide binding]; other site 754093001321 intercalation triad [nucleotide binding]; other site 754093001322 substrate specificity determining residue; other site 754093001323 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 754093001324 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 754093001325 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 754093001326 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 754093001327 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 754093001328 Fimbrial protein; Region: Fimbrial; pfam00419 754093001329 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 754093001330 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 754093001331 PapC C-terminal domain; Region: PapC_C; pfam13953 754093001332 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 754093001333 PapC N-terminal domain; Region: PapC_N; pfam13954 754093001334 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 754093001335 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093001336 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 754093001337 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 754093001338 dimer interface [polypeptide binding]; other site 754093001339 active site 754093001340 citrylCoA binding site [chemical binding]; other site 754093001341 NADH binding [chemical binding]; other site 754093001342 cationic pore residues; other site 754093001343 oxalacetate/citrate binding site [chemical binding]; other site 754093001344 coenzyme A binding site [chemical binding]; other site 754093001345 catalytic triad [active] 754093001346 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 754093001347 Iron-sulfur protein interface; other site 754093001348 proximal quinone binding site [chemical binding]; other site 754093001349 SdhD (CybS) interface [polypeptide binding]; other site 754093001350 proximal heme binding site [chemical binding]; other site 754093001351 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 754093001352 SdhC subunit interface [polypeptide binding]; other site 754093001353 proximal heme binding site [chemical binding]; other site 754093001354 cardiolipin binding site; other site 754093001355 Iron-sulfur protein interface; other site 754093001356 proximal quinone binding site [chemical binding]; other site 754093001357 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 754093001358 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 754093001359 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 754093001360 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 754093001361 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 754093001362 TPP-binding site [chemical binding]; other site 754093001363 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 754093001364 dimer interface [polypeptide binding]; other site 754093001365 PYR/PP interface [polypeptide binding]; other site 754093001366 TPP binding site [chemical binding]; other site 754093001367 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 754093001368 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 754093001369 E3 interaction surface; other site 754093001370 lipoyl attachment site [posttranslational modification]; other site 754093001371 e3 binding domain; Region: E3_binding; pfam02817 754093001372 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 754093001373 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 754093001374 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 754093001375 CoA-ligase; Region: Ligase_CoA; pfam00549 754093001376 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 754093001377 CoA binding domain; Region: CoA_binding; smart00881 754093001378 CoA-ligase; Region: Ligase_CoA; pfam00549 754093001379 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 754093001380 substrate binding site [chemical binding]; other site 754093001381 B12 cofactor binding site [chemical binding]; other site 754093001382 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 754093001383 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 754093001384 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 754093001385 conserved hypothetical protein; Region: glmL_fam; TIGR01319 754093001386 nucleotide binding site [chemical binding]; other site 754093001387 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 754093001388 B12 binding site [chemical binding]; other site 754093001389 heterodimer interface [polypeptide binding]; other site 754093001390 cobalt ligand [ion binding]; other site 754093001391 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 754093001392 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 754093001393 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 754093001394 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 754093001395 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 754093001396 hypothetical protein; Provisional; Region: PRK10588 754093001397 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 754093001398 active site 754093001399 colicin uptake protein TolQ; Provisional; Region: PRK10801 754093001400 tol-pal system protein YbgF; Provisional; Region: PRK10803 754093001401 Tetratricopeptide repeat; Region: TPR_6; pfam13174 754093001402 Tetratricopeptide repeat; Region: TPR_6; pfam13174 754093001403 quinolinate synthetase; Provisional; Region: PRK09375 754093001404 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 754093001405 zinc transporter ZitB; Provisional; Region: PRK03557 754093001406 YbgS-like protein; Region: YbgS; pfam13985 754093001407 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 754093001408 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 754093001409 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 754093001410 active site 754093001411 catalytic residues [active] 754093001412 galactokinase; Provisional; Region: PRK05101 754093001413 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 754093001414 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 754093001415 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 754093001416 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 754093001417 dimer interface [polypeptide binding]; other site 754093001418 active site 754093001419 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 754093001420 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 754093001421 molybdenum-pterin binding domain; Region: Mop; TIGR00638 754093001422 TOBE domain; Region: TOBE; pfam03459 754093001423 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 754093001424 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 754093001425 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754093001426 substrate binding pocket [chemical binding]; other site 754093001427 membrane-bound complex binding site; other site 754093001428 hinge residues; other site 754093001429 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 754093001430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093001431 putative PBP binding loops; other site 754093001432 ABC-ATPase subunit interface; other site 754093001433 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 754093001434 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093001435 Walker A/P-loop; other site 754093001436 ATP binding site [chemical binding]; other site 754093001437 Q-loop/lid; other site 754093001438 ABC transporter signature motif; other site 754093001439 Walker B; other site 754093001440 D-loop; other site 754093001441 H-loop/switch region; other site 754093001442 molybdenum-pterin binding domain; Region: Mop; TIGR00638 754093001443 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093001444 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093001445 Transposase; Region: HTH_Tnp_1; pfam01527 754093001446 Integrase core domain; Region: rve; pfam00665 754093001447 Integrase core domain; Region: rve_3; pfam13683 754093001448 Transposase; Region: HTH_Tnp_1; cl17663 754093001449 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093001450 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 754093001451 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 754093001452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093001453 S-adenosylmethionine binding site [chemical binding]; other site 754093001454 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 754093001455 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754093001456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093001457 dimer interface [polypeptide binding]; other site 754093001458 conserved gate region; other site 754093001459 putative PBP binding loops; other site 754093001460 ABC-ATPase subunit interface; other site 754093001461 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 754093001462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093001463 dimer interface [polypeptide binding]; other site 754093001464 conserved gate region; other site 754093001465 putative PBP binding loops; other site 754093001466 ABC-ATPase subunit interface; other site 754093001467 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 754093001468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093001469 Walker A/P-loop; other site 754093001470 ATP binding site [chemical binding]; other site 754093001471 Q-loop/lid; other site 754093001472 ABC transporter signature motif; other site 754093001473 Walker B; other site 754093001474 D-loop; other site 754093001475 H-loop/switch region; other site 754093001476 TOBE domain; Region: TOBE_2; pfam08402 754093001477 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 754093001478 dimer interface [polypeptide binding]; other site 754093001479 FMN binding site [chemical binding]; other site 754093001480 NADPH bind site [chemical binding]; other site 754093001481 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 754093001482 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 754093001483 GSH binding site [chemical binding]; other site 754093001484 catalytic residues [active] 754093001485 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 754093001486 trimer interface [polypeptide binding]; other site 754093001487 active site 754093001488 substrate binding site [chemical binding]; other site 754093001489 CoA binding site [chemical binding]; other site 754093001490 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 754093001491 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 754093001492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093001493 dimer interface [polypeptide binding]; other site 754093001494 conserved gate region; other site 754093001495 putative PBP binding loops; other site 754093001496 ABC-ATPase subunit interface; other site 754093001497 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 754093001498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093001499 dimer interface [polypeptide binding]; other site 754093001500 conserved gate region; other site 754093001501 putative PBP binding loops; other site 754093001502 ABC-ATPase subunit interface; other site 754093001503 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 754093001504 catalytic nucleophile [active] 754093001505 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 754093001506 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 754093001507 dimer interface [polypeptide binding]; other site 754093001508 putative functional site; other site 754093001509 putative MPT binding site; other site 754093001510 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 754093001511 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 754093001512 ATP binding site [chemical binding]; other site 754093001513 substrate interface [chemical binding]; other site 754093001514 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 754093001515 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 754093001516 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093001517 active site 754093001518 motif I; other site 754093001519 motif II; other site 754093001520 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 754093001521 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 754093001522 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 754093001523 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 754093001524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093001525 Walker A/P-loop; other site 754093001526 ATP binding site [chemical binding]; other site 754093001527 Q-loop/lid; other site 754093001528 ABC transporter signature motif; other site 754093001529 Walker B; other site 754093001530 D-loop; other site 754093001531 H-loop/switch region; other site 754093001532 ABC transporter; Region: ABC_tran_2; pfam12848 754093001533 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754093001534 L,D-transpeptidase; Provisional; Region: PRK10260 754093001535 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754093001536 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 754093001537 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 754093001538 transmembrane helices; other site 754093001539 manganese transport regulator MntR; Provisional; Region: PRK11050 754093001540 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 754093001541 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 754093001542 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 754093001543 Sulfatase; Region: Sulfatase; pfam00884 754093001544 outer membrane protein X; Provisional; Region: ompX; PRK09408 754093001545 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 754093001546 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754093001547 substrate binding pocket [chemical binding]; other site 754093001548 membrane-bound complex binding site; other site 754093001549 hinge residues; other site 754093001550 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754093001551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093001552 dimer interface [polypeptide binding]; other site 754093001553 conserved gate region; other site 754093001554 putative PBP binding loops; other site 754093001555 ABC-ATPase subunit interface; other site 754093001556 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 754093001557 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 754093001558 Walker A/P-loop; other site 754093001559 ATP binding site [chemical binding]; other site 754093001560 Q-loop/lid; other site 754093001561 ABC transporter signature motif; other site 754093001562 Walker B; other site 754093001563 D-loop; other site 754093001564 H-loop/switch region; other site 754093001565 Mechanosensitive ion channel; Region: MS_channel; pfam00924 754093001566 hypothetical protein; Provisional; Region: PRK10259 754093001567 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 754093001568 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 754093001569 hypothetical protein; Provisional; Region: PRK11019 754093001570 hypothetical protein; Provisional; Region: PRK10259 754093001571 putative dehydrogenase; Provisional; Region: PRK10098 754093001572 glycosyl transferase family protein; Provisional; Region: PRK08136 754093001573 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 754093001574 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 754093001575 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754093001576 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 754093001577 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 754093001578 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754093001579 HlyD family secretion protein; Region: HlyD_3; pfam13437 754093001580 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 754093001581 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 754093001582 Walker A/P-loop; other site 754093001583 ATP binding site [chemical binding]; other site 754093001584 Q-loop/lid; other site 754093001585 ABC transporter signature motif; other site 754093001586 Walker B; other site 754093001587 D-loop; other site 754093001588 H-loop/switch region; other site 754093001589 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 754093001590 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 754093001591 Walker A/P-loop; other site 754093001592 ATP binding site [chemical binding]; other site 754093001593 Q-loop/lid; other site 754093001594 ABC transporter signature motif; other site 754093001595 Walker B; other site 754093001596 D-loop; other site 754093001597 H-loop/switch region; other site 754093001598 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 754093001599 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 754093001600 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 754093001601 putative catalytic site [active] 754093001602 putative metal binding site [ion binding]; other site 754093001603 putative phosphate binding site [ion binding]; other site 754093001604 cardiolipin synthase 2; Provisional; Region: PRK11263 754093001605 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 754093001606 putative active site [active] 754093001607 catalytic site [active] 754093001608 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 754093001609 putative active site [active] 754093001610 catalytic site [active] 754093001611 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093001612 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 754093001613 MoaE homodimer interface [polypeptide binding]; other site 754093001614 MoaD interaction [polypeptide binding]; other site 754093001615 active site residues [active] 754093001616 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 754093001617 trimer interface [polypeptide binding]; other site 754093001618 dimer interface [polypeptide binding]; other site 754093001619 putative active site [active] 754093001620 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 754093001621 MPT binding site; other site 754093001622 trimer interface [polypeptide binding]; other site 754093001623 excinuclease ABC subunit B; Provisional; Region: PRK05298 754093001624 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754093001625 ATP binding site [chemical binding]; other site 754093001626 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754093001627 nucleotide binding region [chemical binding]; other site 754093001628 ATP-binding site [chemical binding]; other site 754093001629 Ultra-violet resistance protein B; Region: UvrB; pfam12344 754093001630 UvrB/uvrC motif; Region: UVR; pfam02151 754093001631 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 754093001632 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 754093001633 substrate-cofactor binding pocket; other site 754093001634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093001635 catalytic residue [active] 754093001636 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 754093001637 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 754093001638 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754093001639 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 754093001640 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 754093001641 active site 754093001642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093001643 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 754093001644 Transposase, Mutator family; Region: Transposase_mut; pfam00872 754093001645 Predicted secreted protein [Function unknown]; Region: COG5445 754093001646 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 754093001647 Predicted secreted protein [Function unknown]; Region: COG5445 754093001648 Stage II sporulation protein; Region: SpoIID; pfam08486 754093001649 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 754093001650 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 754093001651 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 754093001652 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 754093001653 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754093001654 dimer interface [polypeptide binding]; other site 754093001655 phosphorylation site [posttranslational modification] 754093001656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093001657 ATP binding site [chemical binding]; other site 754093001658 Mg2+ binding site [ion binding]; other site 754093001659 G-X-G motif; other site 754093001660 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 754093001661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093001662 active site 754093001663 phosphorylation site [posttranslational modification] 754093001664 intermolecular recognition site; other site 754093001665 dimerization interface [polypeptide binding]; other site 754093001666 transcriptional regulator RcsB; Provisional; Region: PRK10840 754093001667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093001668 active site 754093001669 phosphorylation site [posttranslational modification] 754093001670 intermolecular recognition site; other site 754093001671 dimerization interface [polypeptide binding]; other site 754093001672 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754093001673 DNA binding residues [nucleotide binding] 754093001674 dimerization interface [polypeptide binding]; other site 754093001675 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 754093001676 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 754093001677 trimer interface [polypeptide binding]; other site 754093001678 eyelet of channel; other site 754093001679 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 754093001680 ApbE family; Region: ApbE; pfam02424 754093001681 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 754093001682 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 754093001683 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093001684 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093001685 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 754093001686 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 754093001687 DNA binding site [nucleotide binding] 754093001688 active site 754093001689 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 754093001690 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 754093001691 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 754093001692 Walker A/P-loop; other site 754093001693 ATP binding site [chemical binding]; other site 754093001694 Q-loop/lid; other site 754093001695 ABC transporter signature motif; other site 754093001696 Walker B; other site 754093001697 D-loop; other site 754093001698 H-loop/switch region; other site 754093001699 malate:quinone oxidoreductase; Validated; Region: PRK05257 754093001700 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 754093001701 ferredoxin-type protein; Provisional; Region: PRK10194 754093001702 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 754093001703 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 754093001704 4Fe-4S binding domain; Region: Fer4_5; pfam12801 754093001705 4Fe-4S binding domain; Region: Fer4; cl02805 754093001706 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 754093001707 cytochrome c-type protein NapC; Provisional; Region: PRK10617 754093001708 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 754093001709 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 754093001710 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 754093001711 Walker A/P-loop; other site 754093001712 ATP binding site [chemical binding]; other site 754093001713 Q-loop/lid; other site 754093001714 ABC transporter signature motif; other site 754093001715 Walker B; other site 754093001716 D-loop; other site 754093001717 H-loop/switch region; other site 754093001718 heme exporter protein CcmB; Region: ccmB; TIGR01190 754093001719 heme exporter protein CcmC; Region: ccmC; TIGR01191 754093001720 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 754093001721 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 754093001722 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 754093001723 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 754093001724 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 754093001725 catalytic residues [active] 754093001726 central insert; other site 754093001727 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 754093001728 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 754093001729 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 754093001730 binding surface 754093001731 TPR motif; other site 754093001732 transcriptional regulator NarP; Provisional; Region: PRK10403 754093001733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093001734 active site 754093001735 phosphorylation site [posttranslational modification] 754093001736 intermolecular recognition site; other site 754093001737 dimerization interface [polypeptide binding]; other site 754093001738 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754093001739 DNA binding residues [nucleotide binding] 754093001740 dimerization interface [polypeptide binding]; other site 754093001741 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093001742 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 754093001743 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 754093001744 Sulfatase; Region: Sulfatase; pfam00884 754093001745 Nucleoid-associated protein [General function prediction only]; Region: COG3081 754093001746 nucleoid-associated protein NdpA; Validated; Region: PRK00378 754093001747 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 754093001748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754093001749 ATP binding site [chemical binding]; other site 754093001750 putative Mg++ binding site [ion binding]; other site 754093001751 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754093001752 nucleotide binding region [chemical binding]; other site 754093001753 ATP-binding site [chemical binding]; other site 754093001754 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 754093001755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093001756 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 754093001757 putative substrate translocation pore; other site 754093001758 hypothetical protein; Provisional; Region: PRK11835 754093001759 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 754093001760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093001761 dimer interface [polypeptide binding]; other site 754093001762 conserved gate region; other site 754093001763 putative PBP binding loops; other site 754093001764 ABC-ATPase subunit interface; other site 754093001765 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 754093001766 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 754093001767 phage resistance protein; Provisional; Region: PRK10551 754093001768 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 754093001769 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754093001770 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 754093001771 NlpC/P60 family; Region: NLPC_P60; pfam00877 754093001772 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 754093001773 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 754093001774 active site 754093001775 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 754093001776 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 754093001777 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 754093001778 elongation factor P; Provisional; Region: PRK04542 754093001779 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 754093001780 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 754093001781 RNA binding site [nucleotide binding]; other site 754093001782 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 754093001783 RNA binding site [nucleotide binding]; other site 754093001784 Flagellin N-methylase; Region: FliB; pfam03692 754093001785 sugar efflux transporter B; Provisional; Region: PRK15011 754093001786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093001787 putative substrate translocation pore; other site 754093001788 Fimbrial protein; Region: Fimbrial; cl01416 754093001789 Fimbrial protein; Region: Fimbrial; cl01416 754093001790 putativi pili assembly chaperone; Provisional; Region: PRK11385 754093001791 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 754093001792 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 754093001793 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 754093001794 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 754093001795 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 754093001796 MOSC domain; Region: MOSC; pfam03473 754093001797 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754093001798 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 754093001799 catalytic loop [active] 754093001800 iron binding site [ion binding]; other site 754093001801 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 754093001802 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 754093001803 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 754093001804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093001805 S-adenosylmethionine binding site [chemical binding]; other site 754093001806 ABC transporter ATPase component; Reviewed; Region: PRK11147 754093001807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093001808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093001809 Walker A/P-loop; other site 754093001810 Walker A/P-loop; other site 754093001811 ATP binding site [chemical binding]; other site 754093001812 ATP binding site [chemical binding]; other site 754093001813 Q-loop/lid; other site 754093001814 Q-loop/lid; other site 754093001815 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754093001816 ABC transporter signature motif; other site 754093001817 Walker B; other site 754093001818 D-loop; other site 754093001819 ABC transporter; Region: ABC_tran_2; pfam12848 754093001820 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754093001821 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 754093001822 Paraquat-inducible protein A; Region: PqiA; pfam04403 754093001823 Paraquat-inducible protein A; Region: PqiA; pfam04403 754093001824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 754093001825 Protein of unknown function (DUF330); Region: DUF330; pfam03886 754093001826 ribosome modulation factor; Provisional; Region: PRK14563 754093001827 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 754093001828 active site 1 [active] 754093001829 dimer interface [polypeptide binding]; other site 754093001830 active site 2 [active] 754093001831 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 754093001832 TIGR01666 family membrane protein; Region: YCCS 754093001833 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 754093001834 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 754093001835 Predicted membrane protein [Function unknown]; Region: COG3304 754093001836 Domain of unknown function (DUF307); Region: DUF307; pfam03733 754093001837 Domain of unknown function (DUF307); Region: DUF307; pfam03733 754093001838 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 754093001839 active site 754093001840 dimer interfaces [polypeptide binding]; other site 754093001841 catalytic residues [active] 754093001842 hypothetical protein; Provisional; Region: PRK03641 754093001843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 754093001844 heat shock protein HspQ; Provisional; Region: PRK14129 754093001845 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 754093001846 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 754093001847 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 754093001848 putative RNA binding site [nucleotide binding]; other site 754093001849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093001850 S-adenosylmethionine binding site [chemical binding]; other site 754093001851 Acylphosphatase; Region: Acylphosphatase; cl00551 754093001852 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 754093001853 sulfur transfer protein TusE; Provisional; Region: PRK11508 754093001854 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 754093001855 YccA-like proteins; Region: YccA_like; cd10433 754093001856 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 754093001857 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 754093001858 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 754093001859 hydrogenase 1 large subunit; Provisional; Region: PRK10170 754093001860 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 754093001861 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 754093001862 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 754093001863 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 754093001864 putative substrate-binding site; other site 754093001865 nickel binding site [ion binding]; other site 754093001866 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 754093001867 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 754093001868 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 754093001869 Chain length determinant protein; Region: Wzz; pfam02706 754093001870 Chain length determinant protein; Region: Wzz; cl15801 754093001871 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 754093001872 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 754093001873 Nucleotide binding site [chemical binding]; other site 754093001874 Low molecular weight phosphatase family; Region: LMWPc; cd00115 754093001875 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 754093001876 active site 754093001877 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 754093001878 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 754093001879 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 754093001880 DNA-binding site [nucleotide binding]; DNA binding site 754093001881 RNA-binding motif; other site 754093001882 4Fe-4S binding domain; Region: Fer4_5; pfam12801 754093001883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093001884 ATP binding site [chemical binding]; other site 754093001885 G-X-G motif; other site 754093001886 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 754093001887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093001888 active site 754093001889 phosphorylation site [posttranslational modification] 754093001890 intermolecular recognition site; other site 754093001891 dimerization interface [polypeptide binding]; other site 754093001892 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 754093001893 putative binding surface; other site 754093001894 active site 754093001895 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 754093001896 HAMP domain; Region: HAMP; pfam00672 754093001897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754093001898 dimer interface [polypeptide binding]; other site 754093001899 phosphorylation site [posttranslational modification] 754093001900 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 754093001901 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 754093001902 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 754093001903 putative ligand binding site [chemical binding]; other site 754093001904 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 754093001905 molybdopterin cofactor binding site; other site 754093001906 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 754093001907 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 754093001908 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 754093001909 molybdopterin cofactor binding site; other site 754093001910 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 754093001911 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 754093001912 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 754093001913 HSP70 interaction site [polypeptide binding]; other site 754093001914 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 754093001915 substrate binding site [polypeptide binding]; other site 754093001916 dimer interface [polypeptide binding]; other site 754093001917 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093001918 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093001919 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093001920 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093001921 hypothetical protein; Provisional; Region: PRK10174 754093001922 General stress protein [General function prediction only]; Region: GsiB; COG3729 754093001923 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 754093001924 putative FMN binding site [chemical binding]; other site 754093001925 pyrimidine utilization protein D; Region: RutD; TIGR03611 754093001926 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 754093001927 homotrimer interaction site [polypeptide binding]; other site 754093001928 putative active site [active] 754093001929 Isochorismatase family; Region: Isochorismatase; pfam00857 754093001930 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 754093001931 catalytic triad [active] 754093001932 conserved cis-peptide bond; other site 754093001933 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 754093001934 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 754093001935 Glutamate binding site [chemical binding]; other site 754093001936 NAD binding site [chemical binding]; other site 754093001937 catalytic residues [active] 754093001938 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 754093001939 Na binding site [ion binding]; other site 754093001940 curli assembly protein CsgE; Provisional; Region: PRK10386 754093001941 curli assembly protein CsgF; Provisional; Region: PRK10050 754093001942 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 754093001943 putative hydrolase; Validated; Region: PRK09248 754093001944 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 754093001945 active site 754093001946 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 754093001947 Protein of unknown function (DUF987); Region: DUF987; pfam06174 754093001948 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 754093001949 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 754093001950 MPN+ (JAMM) motif; other site 754093001951 Zinc-binding site [ion binding]; other site 754093001952 Antirestriction protein; Region: Antirestrict; pfam03230 754093001953 Domain of unknown function (DUF932); Region: DUF932; pfam06067 754093001954 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; cl07428 754093001955 Transposase; Region: HTH_Tnp_1; cl17663 754093001956 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093001957 outer membrane receptor FepA; Provisional; Region: PRK13528 754093001958 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 754093001959 N-terminal plug; other site 754093001960 ligand-binding site [chemical binding]; other site 754093001961 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 754093001962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093001963 Transposase; Region: HTH_Tnp_1; pfam01527 754093001964 zinc/cadmium-binding protein; Provisional; Region: PRK10306 754093001965 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 754093001966 TMAO/DMSO reductase; Reviewed; Region: PRK05363 754093001967 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 754093001968 Moco binding site; other site 754093001969 metal coordination site [ion binding]; other site 754093001970 SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins...; Region: SOCS; cl02533 754093001971 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 754093001972 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 754093001973 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 754093001974 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 754093001975 DNA cytosine methylase; Provisional; Region: PRK10458 754093001976 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 754093001977 cofactor binding site; other site 754093001978 DNA binding site [nucleotide binding] 754093001979 substrate interaction site [chemical binding]; other site 754093001980 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 754093001981 additional DNA contacts [nucleotide binding]; other site 754093001982 mismatch recognition site; other site 754093001983 active site 754093001984 zinc binding site [ion binding]; other site 754093001985 DNA intercalation site [nucleotide binding]; other site 754093001986 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 754093001987 EamA-like transporter family; Region: EamA; pfam00892 754093001988 hypothetical protein; Provisional; Region: PRK10062 754093001989 Uncharacterized small protein [Function unknown]; Region: COG5475 754093001990 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 754093001991 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754093001992 metal binding site [ion binding]; metal-binding site 754093001993 active site 754093001994 I-site; other site 754093001995 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 754093001996 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093001997 active site 754093001998 motif I; other site 754093001999 motif II; other site 754093002000 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 754093002001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093002002 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093002003 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093002004 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093002005 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093002006 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093002007 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002008 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 754093002009 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 754093002010 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 754093002011 Transposase; Region: HTH_Tnp_1; cl17663 754093002012 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093002013 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 754093002014 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002015 hypothetical protein; Provisional; Region: PRK09951 754093002016 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 754093002017 CPxP motif; other site 754093002018 putative inner membrane protein; Provisional; Region: PRK11099 754093002019 lipoprotein; Provisional; Region: PRK10397 754093002020 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 754093002021 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 754093002022 active site 754093002023 Na/Ca binding site [ion binding]; other site 754093002024 catalytic site [active] 754093002025 Flagellar protein FliT; Region: FliT; cl05125 754093002026 Flagellar protein FliS; Region: FliS; cl00654 754093002027 flagellar capping protein; Reviewed; Region: fliD; PRK08032 754093002028 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 754093002029 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 754093002030 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 754093002031 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093002032 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093002033 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093002034 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 754093002035 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754093002036 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 754093002037 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754093002038 DNA binding residues [nucleotide binding] 754093002039 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 754093002040 D-cysteine desulfhydrase; Validated; Region: PRK03910 754093002041 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 754093002042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093002043 catalytic residue [active] 754093002044 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754093002045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093002046 dimer interface [polypeptide binding]; other site 754093002047 conserved gate region; other site 754093002048 putative PBP binding loops; other site 754093002049 ABC-ATPase subunit interface; other site 754093002050 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 754093002051 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 754093002052 Walker A/P-loop; other site 754093002053 ATP binding site [chemical binding]; other site 754093002054 Q-loop/lid; other site 754093002055 ABC transporter signature motif; other site 754093002056 Walker B; other site 754093002057 D-loop; other site 754093002058 H-loop/switch region; other site 754093002059 response regulator; Provisional; Region: PRK09483 754093002060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093002061 active site 754093002062 phosphorylation site [posttranslational modification] 754093002063 intermolecular recognition site; other site 754093002064 dimerization interface [polypeptide binding]; other site 754093002065 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754093002066 DNA binding residues [nucleotide binding] 754093002067 dimerization interface [polypeptide binding]; other site 754093002068 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 754093002069 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 754093002070 GIY-YIG motif/motif A; other site 754093002071 active site 754093002072 catalytic site [active] 754093002073 putative DNA binding site [nucleotide binding]; other site 754093002074 metal binding site [ion binding]; metal-binding site 754093002075 UvrB/uvrC motif; Region: UVR; pfam02151 754093002076 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 754093002077 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 754093002078 hypothetical protein; Provisional; Region: PRK10396 754093002079 yecA family protein; Region: ygfB_yecA; TIGR02292 754093002080 SEC-C motif; Region: SEC-C; pfam02810 754093002081 tyrosine transporter TyrP; Provisional; Region: PRK15132 754093002082 aromatic amino acid transport protein; Region: araaP; TIGR00837 754093002083 probable metal-binding protein; Region: matur_matur; TIGR03853 754093002084 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 754093002085 Ferritin-like domain; Region: Ferritin; pfam00210 754093002086 ferroxidase diiron center [ion binding]; other site 754093002087 YecR-like lipoprotein; Region: YecR; pfam13992 754093002088 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 754093002089 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 754093002090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093002091 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093002092 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093002093 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754093002094 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754093002095 TM-ABC transporter signature motif; other site 754093002096 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 754093002097 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 754093002098 hypothetical protein; Provisional; Region: PRK10301 754093002099 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 754093002100 Predicted amidohydrolase [General function prediction only]; Region: COG0388 754093002101 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 754093002102 exodeoxyribonuclease X; Provisional; Region: PRK07983 754093002103 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 754093002104 active site 754093002105 catalytic site [active] 754093002106 substrate binding site [chemical binding]; other site 754093002107 protease 2; Provisional; Region: PRK10115 754093002108 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 754093002109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 754093002110 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 754093002111 putative metal binding site [ion binding]; other site 754093002112 hypothetical protein; Provisional; Region: PRK13680 754093002113 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 754093002114 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 754093002115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754093002116 ATP-grasp domain; Region: ATP-grasp; pfam02222 754093002117 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 754093002118 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 754093002119 active site 754093002120 intersubunit interface [polypeptide binding]; other site 754093002121 catalytic residue [active] 754093002122 phosphogluconate dehydratase; Validated; Region: PRK09054 754093002123 6-phosphogluconate dehydratase; Region: edd; TIGR01196 754093002124 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 754093002125 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 754093002126 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 754093002127 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 754093002128 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 754093002129 putative active site [active] 754093002130 putative peptidase; Provisional; Region: PRK11649 754093002131 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 754093002132 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 754093002133 Peptidase family M23; Region: Peptidase_M23; pfam01551 754093002134 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 754093002135 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 754093002136 metal binding site [ion binding]; metal-binding site 754093002137 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 754093002138 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 754093002139 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 754093002140 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754093002141 ABC-ATPase subunit interface; other site 754093002142 dimer interface [polypeptide binding]; other site 754093002143 putative PBP binding regions; other site 754093002144 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 754093002145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754093002146 Walker A motif; other site 754093002147 ATP binding site [chemical binding]; other site 754093002148 Walker B motif; other site 754093002149 arginine finger; other site 754093002150 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 754093002151 hypothetical protein; Provisional; Region: PRK11470 754093002152 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 754093002153 active site 754093002154 putative DNA-binding cleft [nucleotide binding]; other site 754093002155 dimer interface [polypeptide binding]; other site 754093002156 hypothetical protein; Validated; Region: PRK00110 754093002157 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 754093002158 nudix motif; other site 754093002159 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 754093002160 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 754093002161 dimer interface [polypeptide binding]; other site 754093002162 anticodon binding site; other site 754093002163 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 754093002164 homodimer interface [polypeptide binding]; other site 754093002165 motif 1; other site 754093002166 active site 754093002167 motif 2; other site 754093002168 GAD domain; Region: GAD; pfam02938 754093002169 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 754093002170 motif 3; other site 754093002171 Integrase core domain; Region: rve; pfam00665 754093002172 DDE domain; Region: DDE_Tnp_IS240; pfam13610 754093002173 Integrase core domain; Region: rve_3; pfam13683 754093002174 Integrase core domain; Region: rve; pfam00665 754093002175 Integrase core domain; Region: rve_3; pfam13683 754093002176 Transposase; Region: HTH_Tnp_1; cl17663 754093002177 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093002178 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 754093002179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093002180 S-adenosylmethionine binding site [chemical binding]; other site 754093002181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093002182 S-adenosylmethionine binding site [chemical binding]; other site 754093002183 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 754093002184 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 754093002185 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 754093002186 molybdopterin cofactor binding site [chemical binding]; other site 754093002187 substrate binding site [chemical binding]; other site 754093002188 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 754093002189 molybdopterin cofactor binding site; other site 754093002190 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 754093002191 copper homeostasis protein CutC; Provisional; Region: PRK11572 754093002192 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 754093002193 putative metal binding site [ion binding]; other site 754093002194 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093002195 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093002196 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093002197 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 754093002198 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 754093002199 flagellar motor protein MotA; Validated; Region: PRK09110 754093002200 transcriptional activator FlhC; Provisional; Region: PRK12722 754093002201 transcriptional activator FlhD; Provisional; Region: PRK02909 754093002202 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 754093002203 Ligand Binding Site [chemical binding]; other site 754093002204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093002205 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093002206 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093002207 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002208 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 754093002209 cell division inhibitor MinD; Provisional; Region: PRK10818 754093002210 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 754093002211 Switch I; other site 754093002212 Switch II; other site 754093002213 septum formation inhibitor; Reviewed; Region: minC; PRK03511 754093002214 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 754093002215 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 754093002216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 754093002217 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 754093002218 hypothetical protein; Provisional; Region: PRK10691 754093002219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093002220 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093002221 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093002222 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002223 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093002224 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093002225 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093002226 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 754093002227 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 754093002228 Catalytic site [active] 754093002229 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 754093002230 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 754093002231 active site 754093002232 DNA binding site [nucleotide binding] 754093002233 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 754093002234 disulfide bond formation protein B; Provisional; Region: PRK01749 754093002235 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 754093002236 transmembrane helices; other site 754093002237 SpoVR family protein; Provisional; Region: PRK11767 754093002238 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 754093002239 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 754093002240 catalytic residue [active] 754093002241 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 754093002242 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 754093002243 TrkA-C domain; Region: TrkA_C; pfam02080 754093002244 Transporter associated domain; Region: CorC_HlyC; smart01091 754093002245 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 754093002246 dimer interface [polypeptide binding]; other site 754093002247 catalytic triad [active] 754093002248 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 754093002249 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754093002250 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754093002251 catalytic residue [active] 754093002252 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 754093002253 Flagellar regulator YcgR; Region: YcgR; pfam07317 754093002254 PilZ domain; Region: PilZ; pfam07238 754093002255 hypothetical protein; Provisional; Region: PRK10457 754093002256 molybdenum transport protein ModD; Provisional; Region: PRK06096 754093002257 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 754093002258 dimerization interface [polypeptide binding]; other site 754093002259 active site 754093002260 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 754093002261 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754093002262 ABC-ATPase subunit interface; other site 754093002263 dimer interface [polypeptide binding]; other site 754093002264 putative PBP binding regions; other site 754093002265 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 754093002266 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 754093002267 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 754093002268 DAK2 domain; Region: Dak2; cl03685 754093002269 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 754093002270 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 754093002271 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 754093002272 Autotransporter beta-domain; Region: Autotransporter; pfam03797 754093002273 GTP-binding protein YchF; Reviewed; Region: PRK09601 754093002274 YchF GTPase; Region: YchF; cd01900 754093002275 G1 box; other site 754093002276 GTP/Mg2+ binding site [chemical binding]; other site 754093002277 Switch I region; other site 754093002278 G2 box; other site 754093002279 Switch II region; other site 754093002280 G3 box; other site 754093002281 G4 box; other site 754093002282 G5 box; other site 754093002283 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 754093002284 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 754093002285 putative active site [active] 754093002286 catalytic residue [active] 754093002287 hypothetical protein; Provisional; Region: PRK10692 754093002288 putative transporter; Provisional; Region: PRK11660 754093002289 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 754093002290 Sulfate transporter family; Region: Sulfate_transp; pfam00916 754093002291 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 754093002292 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 754093002293 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 754093002294 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 754093002295 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 754093002296 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 754093002297 peptide chain release factor 1; Validated; Region: prfA; PRK00591 754093002298 This domain is found in peptide chain release factors; Region: PCRF; smart00937 754093002299 RF-1 domain; Region: RF-1; pfam00472 754093002300 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 754093002301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093002302 hypothetical protein; Provisional; Region: PRK10278 754093002303 hypothetical protein; Provisional; Region: PRK10941 754093002304 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 754093002305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 754093002306 TPR motif; other site 754093002307 binding surface 754093002308 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 754093002309 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 754093002310 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 754093002311 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 754093002312 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093002313 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093002314 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093002315 cation transport regulator; Reviewed; Region: chaB; PRK09582 754093002316 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 754093002317 transcriptional regulator NarL; Provisional; Region: PRK10651 754093002318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093002319 active site 754093002320 phosphorylation site [posttranslational modification] 754093002321 intermolecular recognition site; other site 754093002322 dimerization interface [polypeptide binding]; other site 754093002323 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754093002324 DNA binding residues [nucleotide binding] 754093002325 dimerization interface [polypeptide binding]; other site 754093002326 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 754093002327 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 754093002328 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754093002329 dimerization interface [polypeptide binding]; other site 754093002330 Histidine kinase; Region: HisKA_3; pfam07730 754093002331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093002332 ATP binding site [chemical binding]; other site 754093002333 Mg2+ binding site [ion binding]; other site 754093002334 G-X-G motif; other site 754093002335 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 754093002336 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 754093002337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093002338 active site 754093002339 response regulator of RpoS; Provisional; Region: PRK10693 754093002340 phosphorylation site [posttranslational modification] 754093002341 intermolecular recognition site; other site 754093002342 dimerization interface [polypeptide binding]; other site 754093002343 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 754093002344 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 754093002345 active site 754093002346 tetramer interface; other site 754093002347 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 754093002348 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 754093002349 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 754093002350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093002351 dimer interface [polypeptide binding]; other site 754093002352 conserved gate region; other site 754093002353 putative PBP binding loops; other site 754093002354 ABC-ATPase subunit interface; other site 754093002355 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 754093002356 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 754093002357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093002358 dimer interface [polypeptide binding]; other site 754093002359 conserved gate region; other site 754093002360 putative PBP binding loops; other site 754093002361 ABC-ATPase subunit interface; other site 754093002362 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 754093002363 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754093002364 Walker A/P-loop; other site 754093002365 ATP binding site [chemical binding]; other site 754093002366 Q-loop/lid; other site 754093002367 ABC transporter signature motif; other site 754093002368 Walker B; other site 754093002369 D-loop; other site 754093002370 H-loop/switch region; other site 754093002371 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 754093002372 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 754093002373 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754093002374 Walker A/P-loop; other site 754093002375 ATP binding site [chemical binding]; other site 754093002376 Q-loop/lid; other site 754093002377 ABC transporter signature motif; other site 754093002378 Walker B; other site 754093002379 D-loop; other site 754093002380 H-loop/switch region; other site 754093002381 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 754093002382 dsDNA-mimic protein; Reviewed; Region: PRK05094 754093002383 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 754093002384 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 754093002385 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 754093002386 putative active site [active] 754093002387 catalytic site [active] 754093002388 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 754093002389 putative active site [active] 754093002390 catalytic site [active] 754093002391 YciI-like protein; Reviewed; Region: PRK11370 754093002392 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 754093002393 multiple promoter invertase; Provisional; Region: mpi; PRK13413 754093002394 catalytic residues [active] 754093002395 catalytic nucleophile [active] 754093002396 Presynaptic Site I dimer interface [polypeptide binding]; other site 754093002397 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 754093002398 Synaptic Flat tetramer interface [polypeptide binding]; other site 754093002399 Synaptic Site I dimer interface [polypeptide binding]; other site 754093002400 DNA binding site [nucleotide binding] 754093002401 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 754093002402 intracellular septation protein A; Reviewed; Region: PRK00259 754093002403 hypothetical protein; Provisional; Region: PRK02868 754093002404 outer membrane protein W; Provisional; Region: PRK10959 754093002405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 754093002406 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 754093002407 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 754093002408 substrate binding site [chemical binding]; other site 754093002409 active site 754093002410 catalytic residues [active] 754093002411 heterodimer interface [polypeptide binding]; other site 754093002412 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 754093002413 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 754093002414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093002415 catalytic residue [active] 754093002416 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 754093002417 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 754093002418 active site 754093002419 ribulose/triose binding site [chemical binding]; other site 754093002420 phosphate binding site [ion binding]; other site 754093002421 substrate (anthranilate) binding pocket [chemical binding]; other site 754093002422 product (indole) binding pocket [chemical binding]; other site 754093002423 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 754093002424 active site 754093002425 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 754093002426 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 754093002427 glutamine binding [chemical binding]; other site 754093002428 catalytic triad [active] 754093002429 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 754093002430 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 754093002431 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 754093002432 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 754093002433 active site 754093002434 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 754093002435 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 754093002436 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 754093002437 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754093002438 RNA binding surface [nucleotide binding]; other site 754093002439 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 754093002440 probable active site [active] 754093002441 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 754093002442 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 754093002443 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 754093002444 homodimer interface [polypeptide binding]; other site 754093002445 Walker A motif; other site 754093002446 ATP binding site [chemical binding]; other site 754093002447 hydroxycobalamin binding site [chemical binding]; other site 754093002448 Walker B motif; other site 754093002449 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 754093002450 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 754093002451 NADP binding site [chemical binding]; other site 754093002452 homodimer interface [polypeptide binding]; other site 754093002453 active site 754093002454 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 754093002455 putative inner membrane peptidase; Provisional; Region: PRK11778 754093002456 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 754093002457 tandem repeat interface [polypeptide binding]; other site 754093002458 oligomer interface [polypeptide binding]; other site 754093002459 active site residues [active] 754093002460 hypothetical protein; Provisional; Region: PRK11037 754093002461 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 754093002462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093002463 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 754093002464 substrate binding site [chemical binding]; other site 754093002465 putative dimerization interface [polypeptide binding]; other site 754093002466 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002467 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 754093002468 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 754093002469 substrate binding site [chemical binding]; other site 754093002470 ligand binding site [chemical binding]; other site 754093002471 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 754093002472 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 754093002473 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 754093002474 active site 754093002475 Predicted membrane protein [Function unknown]; Region: COG3771 754093002476 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 754093002477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 754093002478 TPR motif; other site 754093002479 binding surface 754093002480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754093002481 binding surface 754093002482 TPR motif; other site 754093002483 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 754093002484 active site 754093002485 dimer interface [polypeptide binding]; other site 754093002486 translation initiation factor Sui1; Validated; Region: PRK06824 754093002487 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 754093002488 putative rRNA binding site [nucleotide binding]; other site 754093002489 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 754093002490 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 754093002491 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754093002492 hypothetical protein; Provisional; Region: PRK13658 754093002493 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754093002494 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754093002495 metal binding site [ion binding]; metal-binding site 754093002496 active site 754093002497 I-site; other site 754093002498 exoribonuclease II; Provisional; Region: PRK05054 754093002499 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 754093002500 RNB domain; Region: RNB; pfam00773 754093002501 S1 RNA binding domain; Region: S1; pfam00575 754093002502 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 754093002503 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 754093002504 NAD binding site [chemical binding]; other site 754093002505 homotetramer interface [polypeptide binding]; other site 754093002506 homodimer interface [polypeptide binding]; other site 754093002507 substrate binding site [chemical binding]; other site 754093002508 active site 754093002509 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002510 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 754093002511 Outer membrane efflux protein; Region: OEP; pfam02321 754093002512 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 754093002513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093002514 putative substrate translocation pore; other site 754093002515 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 754093002516 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754093002517 Walker A/P-loop; other site 754093002518 ATP binding site [chemical binding]; other site 754093002519 Q-loop/lid; other site 754093002520 ABC transporter signature motif; other site 754093002521 Walker B; other site 754093002522 D-loop; other site 754093002523 H-loop/switch region; other site 754093002524 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 754093002525 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754093002526 Walker A/P-loop; other site 754093002527 ATP binding site [chemical binding]; other site 754093002528 Q-loop/lid; other site 754093002529 ABC transporter signature motif; other site 754093002530 Walker B; other site 754093002531 D-loop; other site 754093002532 H-loop/switch region; other site 754093002533 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754093002534 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 754093002535 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 754093002536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093002537 dimer interface [polypeptide binding]; other site 754093002538 conserved gate region; other site 754093002539 putative PBP binding loops; other site 754093002540 ABC-ATPase subunit interface; other site 754093002541 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 754093002542 phage recombination protein Bet; Region: bet_lambda; TIGR01913 754093002543 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 754093002544 Ribosome inactivating protein; Region: RIP; pfam00161 754093002545 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 754093002546 Domain of unknown function (DUF303); Region: DUF303; pfam03629 754093002547 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 754093002548 Protein of unknown function (DUF826); Region: DUF826; pfam05696 754093002549 Lysis protein S; Region: Lysis_S; pfam04971 754093002550 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 754093002551 catalytic residues [active] 754093002552 Predicted ATPase [General function prediction only]; Region: COG3106 754093002553 hypothetical protein; Provisional; Region: PRK05415 754093002554 TIGR01620 family protein; Region: hyp_HI0043 754093002555 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 754093002556 dimer interface [polypeptide binding]; other site 754093002557 catalytic triad [active] 754093002558 peroxidatic and resolving cysteines [active] 754093002559 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 754093002560 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 754093002561 active site 754093002562 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002563 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754093002564 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093002565 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 754093002566 putative effector binding pocket; other site 754093002567 putative dimerization interface [polypeptide binding]; other site 754093002568 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 754093002569 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 754093002570 peptide binding site [polypeptide binding]; other site 754093002571 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 754093002572 Mechanosensitive ion channel; Region: MS_channel; pfam00924 754093002573 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 754093002574 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002575 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 754093002576 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 754093002577 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 754093002578 DNA binding site [nucleotide binding] 754093002579 active site 754093002580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 754093002581 Smr domain; Region: Smr; pfam01713 754093002582 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754093002583 I-site; other site 754093002584 active site 754093002585 metal binding site [ion binding]; metal-binding site 754093002586 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754093002587 nucleotide binding region [chemical binding]; other site 754093002588 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 754093002589 ATP-binding site [chemical binding]; other site 754093002590 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 754093002591 putative RNA binding site [nucleotide binding]; other site 754093002592 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002593 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002594 Protein of unknown function (DUF968); Region: DUF968; pfam06147 754093002595 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 754093002596 Antitermination protein; Region: Antiterm; pfam03589 754093002597 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 754093002598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093002599 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093002600 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093002601 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002602 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 754093002603 Lysis protein S; Region: Lysis_S; pfam04971 754093002604 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 754093002605 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754093002606 ABC-ATPase subunit interface; other site 754093002607 dimer interface [polypeptide binding]; other site 754093002608 putative PBP binding regions; other site 754093002609 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 754093002610 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 754093002611 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 754093002612 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 754093002613 metal binding site [ion binding]; metal-binding site 754093002614 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 754093002615 Ligand Binding Site [chemical binding]; other site 754093002616 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 754093002617 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 754093002618 trimer interface [polypeptide binding]; other site 754093002619 eyelet of channel; other site 754093002620 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 754093002621 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 754093002622 dimer interface [polypeptide binding]; other site 754093002623 PYR/PP interface [polypeptide binding]; other site 754093002624 TPP binding site [chemical binding]; other site 754093002625 substrate binding site [chemical binding]; other site 754093002626 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 754093002627 Domain of unknown function; Region: EKR; smart00890 754093002628 4Fe-4S binding domain; Region: Fer4_6; pfam12837 754093002629 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 754093002630 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 754093002631 TPP-binding site [chemical binding]; other site 754093002632 dimer interface [polypeptide binding]; other site 754093002633 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 754093002634 Domain of unknown function (DUF333); Region: DUF333; pfam03891 754093002635 META domain; Region: META; cl01245 754093002636 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 754093002637 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 754093002638 putative ligand binding site [chemical binding]; other site 754093002639 putative NAD binding site [chemical binding]; other site 754093002640 catalytic site [active] 754093002641 hypothetical protein; Provisional; Region: PRK10695 754093002642 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 754093002643 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 754093002644 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 754093002645 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 754093002646 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 754093002647 active site 754093002648 catalytic residue [active] 754093002649 dimer interface [polypeptide binding]; other site 754093002650 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002651 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002652 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093002653 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093002654 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093002655 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093002656 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093002657 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093002658 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002659 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 754093002660 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754093002661 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754093002662 active site 754093002663 catalytic tetrad [active] 754093002664 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 754093002665 active site 754093002666 phosphate binding residues; other site 754093002667 catalytic residues [active] 754093002668 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 754093002669 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 754093002670 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 754093002671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 754093002672 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 754093002673 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 754093002674 putative NAD(P) binding site [chemical binding]; other site 754093002675 catalytic Zn binding site [ion binding]; other site 754093002676 structural Zn binding site [ion binding]; other site 754093002677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093002678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093002679 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754093002680 catalytic tetrad [active] 754093002681 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 754093002682 Isochorismatase family; Region: Isochorismatase; pfam00857 754093002683 catalytic triad [active] 754093002684 metal binding site [ion binding]; metal-binding site 754093002685 conserved cis-peptide bond; other site 754093002686 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 754093002687 putative FMN binding site [chemical binding]; other site 754093002688 selenophosphate synthetase; Provisional; Region: PRK00943 754093002689 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 754093002690 dimerization interface [polypeptide binding]; other site 754093002691 putative ATP binding site [chemical binding]; other site 754093002692 glutamate dehydrogenase; Provisional; Region: PRK09414 754093002693 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 754093002694 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 754093002695 NAD(P) binding site [chemical binding]; other site 754093002696 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 754093002697 active site 754093002698 8-oxo-dGMP binding site [chemical binding]; other site 754093002699 nudix motif; other site 754093002700 metal binding site [ion binding]; metal-binding site 754093002701 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 754093002702 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 754093002703 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 754093002704 active site residue [active] 754093002705 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 754093002706 active site residue [active] 754093002707 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 754093002708 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093002709 Walker A/P-loop; other site 754093002710 ATP binding site [chemical binding]; other site 754093002711 Q-loop/lid; other site 754093002712 ABC transporter signature motif; other site 754093002713 Walker B; other site 754093002714 D-loop; other site 754093002715 H-loop/switch region; other site 754093002716 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 754093002717 hypothetical protein; Provisional; Region: PRK11622 754093002718 hypothetical protein; Provisional; Region: PRK11622 754093002719 Uncharacterized conserved protein [Function unknown]; Region: COG2128 754093002720 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 754093002721 Uncharacterized conserved protein [Function unknown]; Region: COG0398 754093002722 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 754093002723 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 754093002724 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754093002725 arginine succinyltransferase; Provisional; Region: PRK10456 754093002726 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 754093002727 succinylarginine dihydrolase; Provisional; Region: PRK13281 754093002728 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 754093002729 dimer interface [polypeptide binding]; other site 754093002730 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002731 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002732 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 754093002733 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 754093002734 GIY-YIG motif/motif A; other site 754093002735 active site 754093002736 catalytic site [active] 754093002737 putative DNA binding site [nucleotide binding]; other site 754093002738 metal binding site [ion binding]; metal-binding site 754093002739 NAD+ synthetase; Region: nadE; TIGR00552 754093002740 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 754093002741 homodimer interface [polypeptide binding]; other site 754093002742 NAD binding pocket [chemical binding]; other site 754093002743 ATP binding pocket [chemical binding]; other site 754093002744 Mg binding site [ion binding]; other site 754093002745 active-site loop [active] 754093002746 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 754093002747 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 754093002748 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 754093002749 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 754093002750 Spore germination protein; Region: Spore_permease; cl17796 754093002751 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 754093002752 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 754093002753 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 754093002754 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 754093002755 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 754093002756 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 754093002757 Domain of unknown function DUF20; Region: UPF0118; pfam01594 754093002758 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 754093002759 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 754093002760 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 754093002761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093002762 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 754093002763 dimerization interface [polypeptide binding]; other site 754093002764 substrate binding pocket [chemical binding]; other site 754093002765 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 754093002766 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 754093002767 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 754093002768 nucleotide binding site [chemical binding]; other site 754093002769 putative dithiobiotin synthetase; Provisional; Region: PRK12374 754093002770 AAA domain; Region: AAA_26; pfam13500 754093002771 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 754093002772 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 754093002773 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 754093002774 4Fe-4S binding domain; Region: Fer4; cl02805 754093002775 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 754093002776 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 754093002777 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 754093002778 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 754093002779 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 754093002780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754093002781 Coenzyme A binding pocket [chemical binding]; other site 754093002782 hypothetical protein; Provisional; Region: PRK13659 754093002783 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 754093002784 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093002786 metabolite-proton symporter; Region: 2A0106; TIGR00883 754093002787 putative substrate translocation pore; other site 754093002788 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 754093002789 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 754093002790 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 754093002791 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 754093002792 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 754093002793 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 754093002794 Transcriptional regulators [Transcription]; Region: GntR; COG1802 754093002795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754093002796 DNA-binding site [nucleotide binding]; DNA binding site 754093002797 FCD domain; Region: FCD; pfam07729 754093002798 hypothetical protein; Validated; Region: PRK03657 754093002799 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 754093002800 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093002801 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 754093002802 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 754093002803 inner membrane protein; Provisional; Region: PRK10995 754093002804 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002805 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 754093002806 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 754093002807 aromatic amino acid exporter; Provisional; Region: PRK11689 754093002808 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 754093002809 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 754093002810 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 754093002811 molybdopterin cofactor binding site; other site 754093002812 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 754093002813 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 754093002814 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 754093002815 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754093002816 non-specific DNA binding site [nucleotide binding]; other site 754093002817 salt bridge; other site 754093002818 sequence-specific DNA binding site [nucleotide binding]; other site 754093002819 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 754093002820 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 754093002821 NAD binding site [chemical binding]; other site 754093002822 substrate binding site [chemical binding]; other site 754093002823 catalytic Zn binding site [ion binding]; other site 754093002824 tetramer interface [polypeptide binding]; other site 754093002825 structural Zn binding site [ion binding]; other site 754093002826 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 754093002827 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754093002828 Walker A/P-loop; other site 754093002829 ATP binding site [chemical binding]; other site 754093002830 Q-loop/lid; other site 754093002831 ABC transporter signature motif; other site 754093002832 Walker B; other site 754093002833 D-loop; other site 754093002834 H-loop/switch region; other site 754093002835 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 754093002836 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754093002837 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 754093002838 Walker A/P-loop; other site 754093002839 ATP binding site [chemical binding]; other site 754093002840 Q-loop/lid; other site 754093002841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 754093002842 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 754093002843 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 754093002844 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002845 putative lipoprotein; Provisional; Region: PRK09707 754093002846 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 754093002847 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 754093002848 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 754093002849 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 754093002850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093002851 S-adenosylmethionine binding site [chemical binding]; other site 754093002852 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 754093002853 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 754093002854 altronate oxidoreductase; Provisional; Region: PRK03643 754093002855 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 754093002856 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 754093002857 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 754093002858 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 754093002859 glutaminase; Provisional; Region: PRK00971 754093002860 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 754093002861 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 754093002862 NAD(P) binding site [chemical binding]; other site 754093002863 catalytic residues [active] 754093002864 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754093002865 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093002866 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 754093002867 putative dimerization interface [polypeptide binding]; other site 754093002868 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 754093002869 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 754093002870 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 754093002871 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 754093002872 peptide binding site [polypeptide binding]; other site 754093002873 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 754093002874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093002875 dimer interface [polypeptide binding]; other site 754093002876 conserved gate region; other site 754093002877 putative PBP binding loops; other site 754093002878 ABC-ATPase subunit interface; other site 754093002879 Transposase; Region: HTH_Tnp_1; cl17663 754093002880 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093002881 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 754093002882 hypothetical protein; Provisional; Region: PRK10281 754093002883 putative oxidoreductase; Provisional; Region: PRK09939 754093002884 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 754093002885 putative molybdopterin cofactor binding site [chemical binding]; other site 754093002886 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 754093002887 putative molybdopterin cofactor binding site; other site 754093002888 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 754093002889 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 754093002890 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 754093002891 CoenzymeA binding site [chemical binding]; other site 754093002892 subunit interaction site [polypeptide binding]; other site 754093002893 PHB binding site; other site 754093002894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093002895 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093002896 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093002897 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 754093002898 putative deacylase active site [active] 754093002899 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 754093002900 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093002901 cyanate transporter; Region: CynX; TIGR00896 754093002902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093002903 putative substrate translocation pore; other site 754093002904 Uncharacterized conserved protein [Function unknown]; Region: COG3189 754093002905 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 754093002906 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 754093002907 Domain of unknown function (DUF333); Region: DUF333; pfam03891 754093002908 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 754093002909 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 754093002910 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754093002911 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754093002912 metal binding site [ion binding]; metal-binding site 754093002913 active site 754093002914 I-site; other site 754093002915 hypothetical protein; Provisional; Region: PRK14760 754093002916 hypothetical protein; Provisional; Region: PRK10457 754093002917 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 754093002918 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 754093002919 transcriptional activator TtdR; Provisional; Region: PRK09801 754093002920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093002921 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 754093002922 putative effector binding pocket; other site 754093002923 putative dimerization interface [polypeptide binding]; other site 754093002924 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 754093002925 tartrate dehydrogenase; Region: TTC; TIGR02089 754093002926 BCCT family transporter; Region: BCCT; cl00569 754093002927 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093002928 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 754093002929 hypothetical protein; Provisional; Region: PRK05114 754093002930 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 754093002931 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 754093002932 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 754093002933 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 754093002934 putative active site [active] 754093002935 putative CoA binding site [chemical binding]; other site 754093002936 nudix motif; other site 754093002937 metal binding site [ion binding]; metal-binding site 754093002938 L-serine deaminase; Provisional; Region: PRK15023 754093002939 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 754093002940 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 754093002941 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 754093002942 Prostaglandin dehydrogenases; Region: PGDH; cd05288 754093002943 NAD(P) binding site [chemical binding]; other site 754093002944 substrate binding site [chemical binding]; other site 754093002945 dimer interface [polypeptide binding]; other site 754093002946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 754093002947 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 754093002948 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 754093002949 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 754093002950 tetrameric interface [polypeptide binding]; other site 754093002951 NAD binding site [chemical binding]; other site 754093002952 catalytic residues [active] 754093002953 substrate binding site [chemical binding]; other site 754093002954 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754093002955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093002956 dimer interface [polypeptide binding]; other site 754093002957 conserved gate region; other site 754093002958 ABC-ATPase subunit interface; other site 754093002959 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754093002960 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 754093002961 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093002962 Walker A/P-loop; other site 754093002963 ATP binding site [chemical binding]; other site 754093002964 Q-loop/lid; other site 754093002965 ABC transporter signature motif; other site 754093002966 Walker B; other site 754093002967 D-loop; other site 754093002968 H-loop/switch region; other site 754093002969 TOBE domain; Region: TOBE_2; pfam08402 754093002970 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 754093002971 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754093002972 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 754093002973 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754093002974 sequence-specific DNA binding site [nucleotide binding]; other site 754093002975 salt bridge; other site 754093002976 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 754093002977 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 754093002978 Peptidase family U32; Region: Peptidase_U32; pfam01136 754093002979 Collagenase; Region: DUF3656; pfam12392 754093002980 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 754093002981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754093002982 non-specific DNA binding site [nucleotide binding]; other site 754093002983 salt bridge; other site 754093002984 sequence-specific DNA binding site [nucleotide binding]; other site 754093002985 Cupin domain; Region: Cupin_2; pfam07883 754093002986 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 754093002987 benzoate transporter; Region: benE; TIGR00843 754093002988 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 754093002989 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093002990 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093002991 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093002992 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 754093002993 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 754093002994 putative trimer interface [polypeptide binding]; other site 754093002995 putative CoA binding site [chemical binding]; other site 754093002996 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 754093002997 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 754093002998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 754093002999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 754093003000 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093003001 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093003002 hypothetical protein; Provisional; Region: PRK10040 754093003003 cytochrome b561; Provisional; Region: PRK11513 754093003004 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 754093003005 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 754093003006 azoreductase; Reviewed; Region: PRK00170 754093003007 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 754093003008 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 754093003009 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 754093003010 active site 754093003011 Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cd00127 754093003012 active site 754093003013 catalytic residues [active] 754093003014 Cytidylyltransferase family; Region: CTP_transf_1; cl17467 754093003015 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093003016 Helix-turn-helix domain; Region: HTH_18; pfam12833 754093003017 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093003018 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 754093003019 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 754093003020 oxidoreductase; Provisional; Region: PRK10015 754093003021 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 754093003022 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 754093003023 AMP binding site [chemical binding]; other site 754093003024 active site 754093003025 CoA binding site [chemical binding]; other site 754093003026 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 754093003027 Uncharacterized conserved protein [Function unknown]; Region: COG0397 754093003028 hypothetical protein; Validated; Region: PRK00029 754093003029 NlpC/P60 family; Region: NLPC_P60; pfam00877 754093003030 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 754093003031 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 754093003032 Walker A/P-loop; other site 754093003033 ATP binding site [chemical binding]; other site 754093003034 Q-loop/lid; other site 754093003035 ABC transporter signature motif; other site 754093003036 Walker B; other site 754093003037 D-loop; other site 754093003038 H-loop/switch region; other site 754093003039 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 754093003040 catalytic residues [active] 754093003041 dimer interface [polypeptide binding]; other site 754093003042 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 754093003043 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754093003044 ABC-ATPase subunit interface; other site 754093003045 dimer interface [polypeptide binding]; other site 754093003046 putative PBP binding regions; other site 754093003047 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 754093003048 IHF dimer interface [polypeptide binding]; other site 754093003049 IHF - DNA interface [nucleotide binding]; other site 754093003050 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 754093003051 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 754093003052 putative tRNA-binding site [nucleotide binding]; other site 754093003053 B3/4 domain; Region: B3_4; pfam03483 754093003054 tRNA synthetase B5 domain; Region: B5; smart00874 754093003055 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 754093003056 dimer interface [polypeptide binding]; other site 754093003057 motif 1; other site 754093003058 motif 3; other site 754093003059 motif 2; other site 754093003060 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 754093003061 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 754093003062 23S rRNA binding site [nucleotide binding]; other site 754093003063 L21 binding site [polypeptide binding]; other site 754093003064 L13 binding site [polypeptide binding]; other site 754093003065 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 754093003066 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 754093003067 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 754093003068 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 754093003069 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 754093003070 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 754093003071 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 754093003072 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 754093003073 active site 754093003074 dimer interface [polypeptide binding]; other site 754093003075 motif 1; other site 754093003076 motif 2; other site 754093003077 motif 3; other site 754093003078 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 754093003079 anticodon binding site; other site 754093003080 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 754093003081 Phosphotransferase enzyme family; Region: APH; pfam01636 754093003082 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 754093003083 active site 754093003084 ATP binding site [chemical binding]; other site 754093003085 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 754093003086 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 754093003087 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 754093003088 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093003089 motif II; other site 754093003090 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093003091 sensor protein RstB; Provisional; Region: PRK10604 754093003092 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754093003093 dimerization interface [polypeptide binding]; other site 754093003094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754093003095 dimer interface [polypeptide binding]; other site 754093003096 phosphorylation site [posttranslational modification] 754093003097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093003098 ATP binding site [chemical binding]; other site 754093003099 Mg2+ binding site [ion binding]; other site 754093003100 G-X-G motif; other site 754093003101 fumarate hydratase; Reviewed; Region: fumC; PRK00485 754093003102 Class II fumarases; Region: Fumarase_classII; cd01362 754093003103 active site 754093003104 tetramer interface [polypeptide binding]; other site 754093003105 fumarate hydratase; Provisional; Region: PRK15389 754093003106 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 754093003107 Fumarase C-terminus; Region: Fumerase_C; pfam05683 754093003108 putative outer membrane porin protein; Provisional; Region: PRK11379 754093003109 putative outer membrane porin protein; Provisional; Region: PRK11379 754093003110 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 754093003111 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754093003112 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754093003113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754093003114 active site 754093003115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754093003116 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093003117 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 754093003118 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754093003119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093003120 homodimer interface [polypeptide binding]; other site 754093003121 catalytic residue [active] 754093003122 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 754093003123 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 754093003124 electron transport complex protein RsxA; Provisional; Region: PRK05151 754093003125 electron transport complex protein RnfB; Provisional; Region: PRK05113 754093003126 Putative Fe-S cluster; Region: FeS; pfam04060 754093003127 4Fe-4S binding domain; Region: Fer4; pfam00037 754093003128 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 754093003129 electron transport complex protein RnfG; Validated; Region: PRK01908 754093003130 electron transport complex RsxE subunit; Provisional; Region: PRK12405 754093003131 endonuclease III; Provisional; Region: PRK10702 754093003132 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 754093003133 minor groove reading motif; other site 754093003134 helix-hairpin-helix signature motif; other site 754093003135 substrate binding pocket [chemical binding]; other site 754093003136 active site 754093003137 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 754093003138 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 754093003139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093003140 putative substrate translocation pore; other site 754093003141 POT family; Region: PTR2; pfam00854 754093003142 glutathionine S-transferase; Provisional; Region: PRK10542 754093003143 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 754093003144 C-terminal domain interface [polypeptide binding]; other site 754093003145 GSH binding site (G-site) [chemical binding]; other site 754093003146 dimer interface [polypeptide binding]; other site 754093003147 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 754093003148 N-terminal domain interface [polypeptide binding]; other site 754093003149 dimer interface [polypeptide binding]; other site 754093003150 substrate binding pocket (H-site) [chemical binding]; other site 754093003151 pyridoxamine kinase; Validated; Region: PRK05756 754093003152 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 754093003153 dimer interface [polypeptide binding]; other site 754093003154 pyridoxal binding site [chemical binding]; other site 754093003155 ATP binding site [chemical binding]; other site 754093003156 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 754093003157 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 754093003158 active site 754093003159 HIGH motif; other site 754093003160 dimer interface [polypeptide binding]; other site 754093003161 KMSKS motif; other site 754093003162 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754093003163 RNA binding surface [nucleotide binding]; other site 754093003164 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 754093003165 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 754093003166 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 754093003167 lysozyme inhibitor; Provisional; Region: PRK11372 754093003168 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 754093003169 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 754093003170 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 754093003171 transcriptional regulator SlyA; Provisional; Region: PRK03573 754093003172 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 754093003173 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 754093003174 Fusaric acid resistance protein family; Region: FUSC; pfam04632 754093003175 Fusaric acid resistance protein family; Region: FUSC; pfam04632 754093003176 Predicted Fe-S protein [General function prediction only]; Region: COG3313 754093003177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754093003178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754093003179 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 754093003180 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 754093003181 FMN binding site [chemical binding]; other site 754093003182 active site 754093003183 substrate binding site [chemical binding]; other site 754093003184 catalytic residue [active] 754093003185 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754093003186 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 754093003187 dimer interface [polypeptide binding]; other site 754093003188 active site 754093003189 metal binding site [ion binding]; metal-binding site 754093003190 glutathione binding site [chemical binding]; other site 754093003191 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 754093003192 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 754093003193 dimer interface [polypeptide binding]; other site 754093003194 catalytic site [active] 754093003195 putative active site [active] 754093003196 putative substrate binding site [chemical binding]; other site 754093003197 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 754093003198 putative GSH binding site [chemical binding]; other site 754093003199 catalytic residues [active] 754093003200 superoxide dismutase; Provisional; Region: PRK10543 754093003201 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 754093003202 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 754093003203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093003204 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754093003205 putative substrate translocation pore; other site 754093003206 hypothetical protein; Provisional; Region: PRK14756 754093003207 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 754093003208 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754093003209 DNA binding site [nucleotide binding] 754093003210 domain linker motif; other site 754093003211 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 754093003212 dimerization interface [polypeptide binding]; other site 754093003213 ligand binding site [chemical binding]; other site 754093003214 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 754093003215 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093003216 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754093003217 dimerization interface [polypeptide binding]; other site 754093003218 putative transporter; Provisional; Region: PRK11043 754093003219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093003220 putative substrate translocation pore; other site 754093003221 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 754093003222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 754093003223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093003224 S-adenosylmethionine binding site [chemical binding]; other site 754093003225 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 754093003226 Lumazine binding domain; Region: Lum_binding; pfam00677 754093003227 Lumazine binding domain; Region: Lum_binding; pfam00677 754093003228 multidrug efflux protein; Reviewed; Region: PRK01766 754093003229 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 754093003230 cation binding site [ion binding]; other site 754093003231 hypothetical protein; Provisional; Region: PRK09945 754093003232 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 754093003233 hypothetical protein; Provisional; Region: PRK09897 754093003234 hypothetical protein; Provisional; Region: PRK09946 754093003235 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 754093003236 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 754093003237 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 754093003238 hypothetical protein; Provisional; Region: PRK09947 754093003239 putative oxidoreductase; Provisional; Region: PRK09849 754093003240 hypothetical protein; Provisional; Region: PRK10292 754093003241 pyruvate kinase; Provisional; Region: PRK09206 754093003242 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 754093003243 active site 754093003244 domain interfaces; other site 754093003245 murein lipoprotein; Provisional; Region: PRK15396 754093003246 L,D-transpeptidase; Provisional; Region: PRK10190 754093003247 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 754093003248 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754093003249 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 754093003250 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 754093003251 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754093003252 catalytic residue [active] 754093003253 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 754093003254 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 754093003255 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 754093003256 Walker A/P-loop; other site 754093003257 ATP binding site [chemical binding]; other site 754093003258 Q-loop/lid; other site 754093003259 ABC transporter signature motif; other site 754093003260 Walker B; other site 754093003261 D-loop; other site 754093003262 H-loop/switch region; other site 754093003263 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 754093003264 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 754093003265 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 754093003266 multiple promoter invertase; Provisional; Region: mpi; PRK13413 754093003267 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 754093003268 catalytic residues [active] 754093003269 catalytic nucleophile [active] 754093003270 Presynaptic Site I dimer interface [polypeptide binding]; other site 754093003271 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 754093003272 Synaptic Flat tetramer interface [polypeptide binding]; other site 754093003273 Synaptic Site I dimer interface [polypeptide binding]; other site 754093003274 DNA binding site [nucleotide binding] 754093003275 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 754093003276 DNA-binding interface [nucleotide binding]; DNA binding site 754093003277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754093003278 non-specific DNA binding site [nucleotide binding]; other site 754093003279 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 754093003280 salt bridge; other site 754093003281 sequence-specific DNA binding site [nucleotide binding]; other site 754093003282 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 754093003283 Catalytic site [active] 754093003284 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 754093003285 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093003286 Transposase; Region: HTH_Tnp_1; pfam01527 754093003287 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 754093003288 active site residue [active] 754093003289 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 754093003290 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 754093003291 phage shock protein C; Region: phageshock_pspC; TIGR02978 754093003292 phage shock protein B; Provisional; Region: pspB; PRK09458 754093003293 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 754093003294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754093003295 Walker A motif; other site 754093003296 ATP binding site [chemical binding]; other site 754093003297 Walker B motif; other site 754093003298 arginine finger; other site 754093003299 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754093003300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093003301 catalytic residue [active] 754093003302 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 754093003303 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754093003304 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 754093003305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754093003306 non-specific DNA binding site [nucleotide binding]; other site 754093003307 salt bridge; other site 754093003308 sequence-specific DNA binding site [nucleotide binding]; other site 754093003309 Cupin domain; Region: Cupin_2; pfam07883 754093003310 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754093003311 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 754093003312 C-terminal domain interface [polypeptide binding]; other site 754093003313 GSH binding site (G-site) [chemical binding]; other site 754093003314 dimer interface [polypeptide binding]; other site 754093003315 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 754093003316 dimer interface [polypeptide binding]; other site 754093003317 N-terminal domain interface [polypeptide binding]; other site 754093003318 substrate binding pocket (H-site) [chemical binding]; other site 754093003319 L-asparagine permease; Provisional; Region: PRK15049 754093003320 PQQ-like domain; Region: PQQ_2; pfam13360 754093003321 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 754093003322 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 754093003323 N-terminal plug; other site 754093003324 ligand-binding site [chemical binding]; other site 754093003325 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 754093003326 FCD domain; Region: FCD; pfam07729 754093003327 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093003328 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 754093003329 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754093003330 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 754093003331 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 754093003332 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 754093003333 Transporter associated domain; Region: CorC_HlyC; smart01091 754093003334 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 754093003335 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 754093003336 Predicted membrane protein [Function unknown]; Region: COG4811 754093003337 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 754093003338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093003339 S-adenosylmethionine binding site [chemical binding]; other site 754093003340 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 754093003341 DNA-binding site [nucleotide binding]; DNA binding site 754093003342 RNA-binding motif; other site 754093003343 YebO-like protein; Region: YebO; pfam13974 754093003344 PhoPQ regulatory protein; Provisional; Region: PRK10299 754093003345 YobH-like protein; Region: YobH; pfam13996 754093003346 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 754093003347 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754093003348 dimerization interface [polypeptide binding]; other site 754093003349 putative Zn2+ binding site [ion binding]; other site 754093003350 putative DNA binding site [nucleotide binding]; other site 754093003351 Bacterial transcriptional regulator; Region: IclR; pfam01614 754093003352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093003353 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754093003354 putative substrate translocation pore; other site 754093003355 Predicted integral membrane protein [Function unknown]; Region: COG5521 754093003356 heat shock protein HtpX; Provisional; Region: PRK05457 754093003357 ProP expression regulator; Provisional; Region: PRK04950 754093003358 ProQ/FINO family; Region: ProQ; pfam04352 754093003359 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 754093003360 GAF domain; Region: GAF_2; pfam13185 754093003361 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 754093003362 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 754093003363 mce related protein; Region: MCE; pfam02470 754093003364 mce related protein; Region: MCE; pfam02470 754093003365 mce related protein; Region: MCE; pfam02470 754093003366 mce related protein; Region: MCE; pfam02470 754093003367 mce related protein; Region: MCE; pfam02470 754093003368 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 754093003369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093003370 S-adenosylmethionine binding site [chemical binding]; other site 754093003371 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 754093003372 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 754093003373 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 754093003374 Lysis protein S; Region: Lysis_S; pfam04971 754093003375 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754093003376 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 754093003377 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093003378 isocitrate dehydrogenase; Validated; Region: PRK07362 754093003379 isocitrate dehydrogenase; Reviewed; Region: PRK07006 754093003380 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 754093003381 nudix motif; other site 754093003382 putative lysogenization regulator; Reviewed; Region: PRK00218 754093003383 adenylosuccinate lyase; Provisional; Region: PRK09285 754093003384 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 754093003385 tetramer interface [polypeptide binding]; other site 754093003386 active site 754093003387 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 754093003388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093003389 active site 754093003390 phosphorylation site [posttranslational modification] 754093003391 intermolecular recognition site; other site 754093003392 dimerization interface [polypeptide binding]; other site 754093003393 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754093003394 DNA binding site [nucleotide binding] 754093003395 sensor protein PhoQ; Provisional; Region: PRK10815 754093003396 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 754093003397 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 754093003398 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 754093003399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093003400 ATP binding site [chemical binding]; other site 754093003401 Mg2+ binding site [ion binding]; other site 754093003402 G-X-G motif; other site 754093003403 Uncharacterized conserved protein [Function unknown]; Region: COG2850 754093003404 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 754093003405 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 754093003406 metal binding site [ion binding]; metal-binding site 754093003407 dimer interface [polypeptide binding]; other site 754093003408 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 754093003409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093003410 Walker A/P-loop; other site 754093003411 ATP binding site [chemical binding]; other site 754093003412 Q-loop/lid; other site 754093003413 ABC transporter signature motif; other site 754093003414 Walker B; other site 754093003415 D-loop; other site 754093003416 H-loop/switch region; other site 754093003417 TOBE domain; Region: TOBE_2; pfam08402 754093003418 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754093003419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093003420 dimer interface [polypeptide binding]; other site 754093003421 conserved gate region; other site 754093003422 putative PBP binding loops; other site 754093003423 ABC-ATPase subunit interface; other site 754093003424 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754093003425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093003426 dimer interface [polypeptide binding]; other site 754093003427 conserved gate region; other site 754093003428 putative PBP binding loops; other site 754093003429 ABC-ATPase subunit interface; other site 754093003430 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 754093003431 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 754093003432 NAD-dependent deacetylase; Provisional; Region: PRK00481 754093003433 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 754093003434 NAD+ binding site [chemical binding]; other site 754093003435 substrate binding site [chemical binding]; other site 754093003436 Zn binding site [ion binding]; other site 754093003437 fructokinase; Reviewed; Region: PRK09557 754093003438 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 754093003439 nucleotide binding site [chemical binding]; other site 754093003440 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 754093003441 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 754093003442 FtsX-like permease family; Region: FtsX; pfam02687 754093003443 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 754093003444 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 754093003445 Walker A/P-loop; other site 754093003446 ATP binding site [chemical binding]; other site 754093003447 Q-loop/lid; other site 754093003448 ABC transporter signature motif; other site 754093003449 Walker B; other site 754093003450 D-loop; other site 754093003451 H-loop/switch region; other site 754093003452 Predicted membrane protein [Function unknown]; Region: COG4763 754093003453 Acyltransferase family; Region: Acyl_transf_3; pfam01757 754093003454 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 754093003455 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754093003456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754093003457 hypothetical protein; Provisional; Region: PRK04940 754093003458 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 754093003459 beta-hexosaminidase; Provisional; Region: PRK05337 754093003460 thiamine kinase; Region: ycfN_thiK; TIGR02721 754093003461 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 754093003462 active site 754093003463 substrate binding site [chemical binding]; other site 754093003464 ATP binding site [chemical binding]; other site 754093003465 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 754093003466 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 754093003467 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 754093003468 putative dimer interface [polypeptide binding]; other site 754093003469 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 754093003470 nucleotide binding site/active site [active] 754093003471 HIT family signature motif; other site 754093003472 catalytic residue [active] 754093003473 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 754093003474 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 754093003475 N-terminal plug; other site 754093003476 ligand-binding site [chemical binding]; other site 754093003477 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 754093003478 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 754093003479 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 754093003480 active site turn [active] 754093003481 phosphorylation site [posttranslational modification] 754093003482 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 754093003483 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 754093003484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093003485 catalytic residue [active] 754093003486 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 754093003487 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 754093003488 dimer interface [polypeptide binding]; other site 754093003489 active site 754093003490 acyl carrier protein; Provisional; Region: acpP; PRK00982 754093003491 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 754093003492 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 754093003493 NAD(P) binding site [chemical binding]; other site 754093003494 homotetramer interface [polypeptide binding]; other site 754093003495 homodimer interface [polypeptide binding]; other site 754093003496 active site 754093003497 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 754093003498 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 754093003499 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 754093003500 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 754093003501 dimer interface [polypeptide binding]; other site 754093003502 active site 754093003503 CoA binding pocket [chemical binding]; other site 754093003504 putative phosphate acyltransferase; Provisional; Region: PRK05331 754093003505 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 754093003506 hypothetical protein; Provisional; Region: PRK11193 754093003507 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 754093003508 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754093003509 RNA binding surface [nucleotide binding]; other site 754093003510 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 754093003511 active site 754093003512 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 754093003513 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 754093003514 homodimer interface [polypeptide binding]; other site 754093003515 oligonucleotide binding site [chemical binding]; other site 754093003516 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 754093003517 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 754093003518 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 754093003519 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 754093003520 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 754093003521 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 754093003522 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 754093003523 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 754093003524 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 754093003525 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 754093003526 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 754093003527 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 754093003528 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 754093003529 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 754093003530 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 754093003531 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 754093003532 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 754093003533 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 754093003534 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 754093003535 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 754093003536 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 754093003537 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 754093003538 FlgN protein; Region: FlgN; cl09176 754093003539 FlgN protein; Region: FlgN; cl09176 754093003540 hypothetical protein; Provisional; Region: PRK11239 754093003541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 754093003542 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 754093003543 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 754093003544 glutaredoxin 2; Provisional; Region: PRK10387 754093003545 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 754093003546 C-terminal domain interface [polypeptide binding]; other site 754093003547 GSH binding site (G-site) [chemical binding]; other site 754093003548 catalytic residues [active] 754093003549 putative dimer interface [polypeptide binding]; other site 754093003550 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 754093003551 N-terminal domain interface [polypeptide binding]; other site 754093003552 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 754093003553 active site 754093003554 substrate binding pocket [chemical binding]; other site 754093003555 dimer interface [polypeptide binding]; other site 754093003556 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 754093003557 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 754093003558 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754093003559 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 754093003560 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093003561 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 754093003562 tetramer interface [polypeptide binding]; other site 754093003563 active site 754093003564 putative kinase; Provisional; Region: PRK09954 754093003565 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 754093003566 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 754093003567 substrate binding site [chemical binding]; other site 754093003568 ATP binding site [chemical binding]; other site 754093003569 endonuclease IV; Provisional; Region: PRK01060 754093003570 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 754093003571 AP (apurinic/apyrimidinic) site pocket; other site 754093003572 DNA interaction; other site 754093003573 Metal-binding active site; metal-binding site 754093003574 conserved hypothetical integral membrane protein; Region: TIGR00698 754093003575 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 754093003576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093003577 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 754093003578 putative dimerization interface [polypeptide binding]; other site 754093003579 lysine transporter; Provisional; Region: PRK10836 754093003580 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 754093003581 S-formylglutathione hydrolase; Region: PLN02442 754093003582 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 754093003583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093003584 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093003585 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093003586 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 754093003587 Sulfatase; Region: Sulfatase; cl17466 754093003588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093003589 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093003590 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093003591 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093003592 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 754093003593 homodecamer interface [polypeptide binding]; other site 754093003594 GTP cyclohydrolase I; Provisional; Region: PLN03044 754093003595 active site 754093003596 putative catalytic site residues [active] 754093003597 zinc binding site [ion binding]; other site 754093003598 GTP-CH-I/GFRP interaction surface; other site 754093003599 Protein of unknown function (DUF418); Region: DUF418; cl12135 754093003600 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093003601 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754093003602 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754093003603 TM-ABC transporter signature motif; other site 754093003604 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 754093003605 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 754093003606 putative active site [active] 754093003607 hypothetical protein; Provisional; Region: PRK10711 754093003608 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 754093003609 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 754093003610 FMN binding site [chemical binding]; other site 754093003611 active site 754093003612 catalytic residues [active] 754093003613 substrate binding site [chemical binding]; other site 754093003614 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 754093003615 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 754093003616 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 754093003617 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 754093003618 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 754093003619 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 754093003620 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 754093003621 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 754093003622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093003623 ABC-ATPase subunit interface; other site 754093003624 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093003625 Walker A/P-loop; other site 754093003626 ATP binding site [chemical binding]; other site 754093003627 ABC transporter; Region: ABC_tran; pfam00005 754093003628 Q-loop/lid; other site 754093003629 ABC transporter signature motif; other site 754093003630 Walker B; other site 754093003631 hypothetical protein; Provisional; Region: PRK13681 754093003632 transcriptional regulator MirA; Provisional; Region: PRK15043 754093003633 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 754093003634 DNA binding residues [nucleotide binding] 754093003635 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 754093003636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093003637 active site 754093003638 phosphorylation site [posttranslational modification] 754093003639 intermolecular recognition site; other site 754093003640 dimerization interface [polypeptide binding]; other site 754093003641 LytTr DNA-binding domain; Region: LytTR; pfam04397 754093003642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 754093003643 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 754093003644 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 754093003645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 754093003646 Integrase core domain; Region: rve; pfam00665 754093003647 Integrase core domain; Region: rve_3; pfam13683 754093003648 Transposase; Region: HTH_Tnp_1; cl17663 754093003649 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093003650 WGR domain; Region: WGR; cl01581 754093003651 antiporter inner membrane protein; Provisional; Region: PRK11670 754093003652 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 754093003653 Walker A motif; other site 754093003654 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 754093003655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093003656 active site 754093003657 phosphorylation site [posttranslational modification] 754093003658 intermolecular recognition site; other site 754093003659 dimerization interface [polypeptide binding]; other site 754093003660 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754093003661 DNA binding site [nucleotide binding] 754093003662 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 754093003663 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754093003664 dimerization interface [polypeptide binding]; other site 754093003665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754093003666 dimer interface [polypeptide binding]; other site 754093003667 phosphorylation site [posttranslational modification] 754093003668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093003669 ATP binding site [chemical binding]; other site 754093003670 Mg2+ binding site [ion binding]; other site 754093003671 G-X-G motif; other site 754093003672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093003673 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 754093003674 metal ion-dependent adhesion site (MIDAS); other site 754093003675 Protein phosphatase 2C; Region: PP2C_2; pfam13672 754093003676 putative chaperone; Provisional; Region: PRK11678 754093003677 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 754093003678 nucleotide binding site [chemical binding]; other site 754093003679 putative NEF/HSP70 interaction site [polypeptide binding]; other site 754093003680 SBD interface [polypeptide binding]; other site 754093003681 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 754093003682 AlkA N-terminal domain; Region: AlkA_N; smart01009 754093003683 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 754093003684 minor groove reading motif; other site 754093003685 helix-hairpin-helix signature motif; other site 754093003686 substrate binding pocket [chemical binding]; other site 754093003687 active site 754093003688 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 754093003689 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 754093003690 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754093003691 PAS fold; Region: PAS_3; pfam08447 754093003692 putative active site [active] 754093003693 heme pocket [chemical binding]; other site 754093003694 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754093003695 PAS domain; Region: PAS_9; pfam13426 754093003696 putative active site [active] 754093003697 heme pocket [chemical binding]; other site 754093003698 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 754093003699 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754093003700 metal binding site [ion binding]; metal-binding site 754093003701 active site 754093003702 I-site; other site 754093003703 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 754093003704 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 754093003705 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 754093003706 ATP-binding site [chemical binding]; other site 754093003707 Sugar specificity; other site 754093003708 Pyrimidine base specificity; other site 754093003709 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 754093003710 trimer interface [polypeptide binding]; other site 754093003711 active site 754093003712 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 754093003713 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 754093003714 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 754093003715 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 754093003716 NAD binding site [chemical binding]; other site 754093003717 substrate binding site [chemical binding]; other site 754093003718 homodimer interface [polypeptide binding]; other site 754093003719 active site 754093003720 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 754093003721 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 754093003722 NADP binding site [chemical binding]; other site 754093003723 active site 754093003724 putative substrate binding site [chemical binding]; other site 754093003725 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 754093003726 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 754093003727 substrate binding site; other site 754093003728 tetramer interface; other site 754093003729 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 754093003730 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 754093003731 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 754093003732 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 754093003733 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 754093003734 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 754093003735 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 754093003736 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 754093003737 chain length determinant protein WzzB; Provisional; Region: PRK15471 754093003738 Chain length determinant protein; Region: Wzz; pfam02706 754093003739 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 754093003740 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 754093003741 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 754093003742 metal binding site [ion binding]; metal-binding site 754093003743 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 754093003744 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 754093003745 substrate binding site [chemical binding]; other site 754093003746 glutamase interaction surface [polypeptide binding]; other site 754093003747 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 754093003748 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 754093003749 catalytic residues [active] 754093003750 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 754093003751 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 754093003752 putative active site [active] 754093003753 oxyanion strand; other site 754093003754 catalytic triad [active] 754093003755 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 754093003756 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093003757 active site 754093003758 motif I; other site 754093003759 motif II; other site 754093003760 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 754093003761 putative active site pocket [active] 754093003762 4-fold oligomerization interface [polypeptide binding]; other site 754093003763 metal binding residues [ion binding]; metal-binding site 754093003764 3-fold/trimer interface [polypeptide binding]; other site 754093003765 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 754093003766 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754093003767 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093003768 homodimer interface [polypeptide binding]; other site 754093003769 catalytic residue [active] 754093003770 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754093003771 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 754093003772 putative NAD(P) binding site [chemical binding]; other site 754093003773 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754093003774 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 754093003775 Transposase; Region: HTH_Tnp_1; cl17663 754093003776 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093003777 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 754093003778 CPxP motif; other site 754093003779 DNA gyrase inhibitor; Provisional; Region: PRK10016 754093003780 Predicted membrane protein [Function unknown]; Region: COG1289 754093003781 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 754093003782 hypothetical protein; Provisional; Region: PRK05423 754093003783 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 754093003784 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 754093003785 putative dimer interface [polypeptide binding]; other site 754093003786 active site pocket [active] 754093003787 putative cataytic base [active] 754093003788 L,D-transpeptidase; Provisional; Region: PRK10190 754093003789 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754093003790 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 754093003791 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093003792 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 754093003793 putative substrate binding site [chemical binding]; other site 754093003794 dimerization interface [polypeptide binding]; other site 754093003795 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 754093003796 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093003797 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093003798 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093003799 shikimate transporter; Provisional; Region: PRK09952 754093003800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093003801 putative substrate translocation pore; other site 754093003802 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 754093003803 putative protease; Provisional; Region: PRK15452 754093003804 Peptidase family U32; Region: Peptidase_U32; pfam01136 754093003805 lipid kinase; Reviewed; Region: PRK13054 754093003806 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 754093003807 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 754093003808 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 754093003809 putative NAD(P) binding site [chemical binding]; other site 754093003810 catalytic Zn binding site [ion binding]; other site 754093003811 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 754093003812 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 754093003813 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 754093003814 active site 754093003815 P-loop; other site 754093003816 phosphorylation site [posttranslational modification] 754093003817 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 754093003818 active site 754093003819 phosphorylation site [posttranslational modification] 754093003820 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 754093003821 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 754093003822 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 754093003823 putative active site; other site 754093003824 catalytic residue [active] 754093003825 nucleoside transporter; Region: 2A0110; TIGR00889 754093003826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093003827 putative substrate translocation pore; other site 754093003828 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 754093003829 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754093003830 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 754093003831 substrate binding site [chemical binding]; other site 754093003832 ATP binding site [chemical binding]; other site 754093003833 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 754093003834 active site 754093003835 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 754093003836 dimer interface [polypeptide binding]; other site 754093003837 substrate binding site [chemical binding]; other site 754093003838 ATP binding site [chemical binding]; other site 754093003839 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 754093003840 substrate binding site [chemical binding]; other site 754093003841 multimerization interface [polypeptide binding]; other site 754093003842 ATP binding site [chemical binding]; other site 754093003843 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 754093003844 putative metal binding site [ion binding]; other site 754093003845 putative homodimer interface [polypeptide binding]; other site 754093003846 putative homotetramer interface [polypeptide binding]; other site 754093003847 putative homodimer-homodimer interface [polypeptide binding]; other site 754093003848 putative allosteric switch controlling residues; other site 754093003849 Predicted integral membrane protein [Function unknown]; Region: COG5455 754093003850 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 754093003851 PapC C-terminal domain; Region: PapC_C; pfam13953 754093003852 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093003853 Transposase; Region: HTH_Tnp_1; pfam01527 754093003854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093003855 putative substrate translocation pore; other site 754093003856 secY/secA suppressor protein; Provisional; Region: PRK11467 754093003857 lipoprotein; Provisional; Region: PRK10175 754093003858 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 754093003859 Acyltransferase family; Region: Acyl_transf_3; pfam01757 754093003860 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 754093003861 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 754093003862 putative active site [active] 754093003863 catalytic site [active] 754093003864 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 754093003865 putative active site [active] 754093003866 catalytic site [active] 754093003867 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 754093003868 putative ADP-ribose binding site [chemical binding]; other site 754093003869 putative active site [active] 754093003870 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 754093003871 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 754093003872 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 754093003873 putative substrate binding site [chemical binding]; other site 754093003874 putative ATP binding site [chemical binding]; other site 754093003875 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 754093003876 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 754093003877 active site 754093003878 phosphorylation site [posttranslational modification] 754093003879 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 754093003880 dimerization domain swap beta strand [polypeptide binding]; other site 754093003881 regulatory protein interface [polypeptide binding]; other site 754093003882 active site 754093003883 regulatory phosphorylation site [posttranslational modification]; other site 754093003884 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 754093003885 active site 754093003886 dimer interface [polypeptide binding]; other site 754093003887 non-prolyl cis peptide bond; other site 754093003888 aminopeptidase N; Provisional; Region: pepN; PRK14015 754093003889 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 754093003890 active site 754093003891 Zn binding site [ion binding]; other site 754093003892 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 754093003893 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 754093003894 trimer interface [polypeptide binding]; other site 754093003895 eyelet of channel; other site 754093003896 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 754093003897 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754093003898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093003899 homodimer interface [polypeptide binding]; other site 754093003900 catalytic residue [active] 754093003901 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 754093003902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 754093003903 Peptidase M15; Region: Peptidase_M15_3; cl01194 754093003904 murein L,D-transpeptidase; Provisional; Region: PRK10594 754093003905 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 754093003906 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754093003907 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754093003908 condesin subunit E; Provisional; Region: PRK05256 754093003909 condesin subunit F; Provisional; Region: PRK05260 754093003910 Methyltransferase domain; Region: Methyltransf_31; pfam13847 754093003911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093003912 S-adenosylmethionine binding site [chemical binding]; other site 754093003913 Uncharacterized conserved protein [Function unknown]; Region: COG1434 754093003914 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 754093003915 putative active site [active] 754093003916 hypothetical protein; Provisional; Region: PRK10593 754093003917 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 754093003918 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 754093003919 Ligand binding site; other site 754093003920 oligomer interface; other site 754093003921 hypothetical protein; Provisional; Region: PRK11827 754093003922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 754093003923 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 754093003924 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 754093003925 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 754093003926 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 754093003927 IHF dimer interface [polypeptide binding]; other site 754093003928 IHF - DNA interface [nucleotide binding]; other site 754093003929 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 754093003930 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 754093003931 RNA binding site [nucleotide binding]; other site 754093003932 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 754093003933 RNA binding site [nucleotide binding]; other site 754093003934 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 754093003935 RNA binding site [nucleotide binding]; other site 754093003936 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 754093003937 RNA binding site [nucleotide binding]; other site 754093003938 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 754093003939 RNA binding site [nucleotide binding]; other site 754093003940 cytidylate kinase; Provisional; Region: cmk; PRK00023 754093003941 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 754093003942 CMP-binding site; other site 754093003943 The sites determining sugar specificity; other site 754093003944 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 754093003945 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 754093003946 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 754093003947 hinge; other site 754093003948 active site 754093003949 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 754093003950 homodimer interface [polypeptide binding]; other site 754093003951 substrate-cofactor binding pocket; other site 754093003952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093003953 catalytic residue [active] 754093003954 Predicted membrane protein [Function unknown]; Region: COG2323 754093003955 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 754093003956 Pyruvate formate lyase 1; Region: PFL1; cd01678 754093003957 coenzyme A binding site [chemical binding]; other site 754093003958 active site 754093003959 catalytic residues [active] 754093003960 glycine loop; other site 754093003961 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754093003962 FeS/SAM binding site; other site 754093003963 pyruvate formate lyase II activase; Provisional; Region: PRK10076 754093003964 putative MFS family transporter protein; Provisional; Region: PRK03633 754093003965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093003966 putative substrate translocation pore; other site 754093003967 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 754093003968 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 754093003969 4Fe-4S binding domain; Region: Fer4; pfam00037 754093003970 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 754093003971 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 754093003972 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 754093003973 putative [Fe4-S4] binding site [ion binding]; other site 754093003974 putative molybdopterin cofactor binding site [chemical binding]; other site 754093003975 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 754093003976 putative molybdopterin cofactor binding site; other site 754093003977 recombination factor protein RarA; Reviewed; Region: PRK13342 754093003978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754093003979 Walker A motif; other site 754093003980 ATP binding site [chemical binding]; other site 754093003981 Walker B motif; other site 754093003982 arginine finger; other site 754093003983 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 754093003984 periplasmic chaperone LolA; Region: lolA; TIGR00547 754093003985 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 754093003986 DNA translocase FtsK; Provisional; Region: PRK10263 754093003987 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 754093003988 DNA translocase FtsK; Provisional; Region: PRK10263 754093003989 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 754093003990 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 754093003991 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 754093003992 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754093003993 putative DNA binding site [nucleotide binding]; other site 754093003994 putative Zn2+ binding site [ion binding]; other site 754093003995 AsnC family; Region: AsnC_trans_reg; pfam01037 754093003996 thioredoxin reductase; Provisional; Region: PRK10262 754093003997 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754093003998 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754093003999 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 754093004000 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754093004001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093004002 Walker A/P-loop; other site 754093004003 ATP binding site [chemical binding]; other site 754093004004 Q-loop/lid; other site 754093004005 ABC transporter signature motif; other site 754093004006 Walker B; other site 754093004007 D-loop; other site 754093004008 H-loop/switch region; other site 754093004009 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 754093004010 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754093004011 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 754093004012 Walker A/P-loop; other site 754093004013 ATP binding site [chemical binding]; other site 754093004014 Q-loop/lid; other site 754093004015 ABC transporter signature motif; other site 754093004016 Walker B; other site 754093004017 D-loop; other site 754093004018 H-loop/switch region; other site 754093004019 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 754093004020 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 754093004021 rRNA binding site [nucleotide binding]; other site 754093004022 predicted 30S ribosome binding site; other site 754093004023 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 754093004024 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 754093004025 DNA-binding site [nucleotide binding]; DNA binding site 754093004026 RNA-binding motif; other site 754093004027 macrolide transporter subunit MacA; Provisional; Region: PRK11578 754093004028 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754093004029 HlyD family secretion protein; Region: HlyD_3; pfam13437 754093004030 Protein of unknown function (DUF535); Region: DUF535; pfam04393 754093004031 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 754093004032 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 754093004033 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 754093004034 putative active site [active] 754093004035 putative metal-binding site [ion binding]; other site 754093004036 Predicted membrane protein [Function unknown]; Region: COG2431 754093004037 hybrid cluster protein; Provisional; Region: PRK05290 754093004038 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 754093004039 ACS interaction site; other site 754093004040 CODH interaction site; other site 754093004041 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 754093004042 hybrid metal cluster; other site 754093004043 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 754093004044 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 754093004045 FAD binding pocket [chemical binding]; other site 754093004046 FAD binding motif [chemical binding]; other site 754093004047 phosphate binding motif [ion binding]; other site 754093004048 beta-alpha-beta structure motif; other site 754093004049 NAD binding pocket [chemical binding]; other site 754093004050 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754093004051 catalytic loop [active] 754093004052 iron binding site [ion binding]; other site 754093004053 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 754093004054 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 754093004055 tetramer interface [polypeptide binding]; other site 754093004056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093004057 catalytic residue [active] 754093004058 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 754093004059 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 754093004060 amidase catalytic site [active] 754093004061 Zn binding residues [ion binding]; other site 754093004062 substrate binding site [chemical binding]; other site 754093004063 hypothetical protein; Provisional; Region: PRK02877 754093004064 putative lipoprotein; Provisional; Region: PRK10533 754093004065 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 754093004066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093004067 Walker A/P-loop; other site 754093004068 ATP binding site [chemical binding]; other site 754093004069 Q-loop/lid; other site 754093004070 ABC transporter signature motif; other site 754093004071 Walker B; other site 754093004072 D-loop; other site 754093004073 H-loop/switch region; other site 754093004074 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 754093004075 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754093004076 substrate binding pocket [chemical binding]; other site 754093004077 membrane-bound complex binding site; other site 754093004078 hinge residues; other site 754093004079 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754093004080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093004081 dimer interface [polypeptide binding]; other site 754093004082 conserved gate region; other site 754093004083 putative PBP binding loops; other site 754093004084 ABC-ATPase subunit interface; other site 754093004085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093004086 dimer interface [polypeptide binding]; other site 754093004087 conserved gate region; other site 754093004088 putative PBP binding loops; other site 754093004089 ABC-ATPase subunit interface; other site 754093004090 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754093004091 substrate binding pocket [chemical binding]; other site 754093004092 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093004093 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 754093004094 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 754093004095 Ash protein family; Region: Phage_ASH; pfam10554 754093004096 ORF6N domain; Region: ORF6N; pfam10543 754093004097 Phage anti-repressor protein [Transcription]; Region: COG3561 754093004098 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 754093004099 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754093004100 salt bridge; other site 754093004101 non-specific DNA binding site [nucleotide binding]; other site 754093004102 sequence-specific DNA binding site [nucleotide binding]; other site 754093004103 NinB protein; Region: NinB; pfam05772 754093004104 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 754093004105 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 754093004106 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 754093004107 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 754093004108 dimer interface [polypeptide binding]; other site 754093004109 active site 754093004110 Int/Topo IB signature motif; other site 754093004111 Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; cl01916 754093004112 Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; cl01916 754093004113 DNA gyrase subunit A; Validated; Region: PRK05560 754093004114 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 754093004115 CAP-like domain; other site 754093004116 active site 754093004117 primary dimer interface [polypeptide binding]; other site 754093004118 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754093004119 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754093004120 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754093004121 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754093004122 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754093004123 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754093004124 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 754093004125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093004126 S-adenosylmethionine binding site [chemical binding]; other site 754093004127 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 754093004128 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 754093004129 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 754093004130 Autotransporter beta-domain; Region: Autotransporter; pfam03797 754093004131 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 754093004132 ATP cone domain; Region: ATP-cone; pfam03477 754093004133 Class I ribonucleotide reductase; Region: RNR_I; cd01679 754093004134 active site 754093004135 dimer interface [polypeptide binding]; other site 754093004136 catalytic residues [active] 754093004137 effector binding site; other site 754093004138 R2 peptide binding site; other site 754093004139 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 754093004140 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754093004141 catalytic loop [active] 754093004142 iron binding site [ion binding]; other site 754093004143 hypothetical protein; Provisional; Region: PRK09902 754093004144 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754093004145 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093004146 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754093004147 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 754093004148 dimerization interface [polypeptide binding]; other site 754093004149 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 754093004150 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 754093004151 active site 754093004152 catalytic site [active] 754093004153 metal binding site [ion binding]; metal-binding site 754093004154 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 754093004155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093004156 putative substrate translocation pore; other site 754093004157 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 754093004158 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754093004159 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 754093004160 hypothetical protein; Provisional; Region: PRK09956 754093004161 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 754093004162 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 754093004163 D-galactonate transporter; Region: 2A0114; TIGR00893 754093004164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093004165 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093004166 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093004167 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093004168 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 754093004169 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 754093004170 putative active site pocket [active] 754093004171 putative metal binding site [ion binding]; other site 754093004172 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 754093004173 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 754093004174 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 754093004175 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 754093004176 Ligand binding site; other site 754093004177 Putative Catalytic site; other site 754093004178 DXD motif; other site 754093004179 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 754093004180 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 754093004181 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 754093004182 substrate binding site [chemical binding]; other site 754093004183 cosubstrate binding site; other site 754093004184 catalytic site [active] 754093004185 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 754093004186 active site 754093004187 hexamer interface [polypeptide binding]; other site 754093004188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754093004189 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 754093004190 NAD(P) binding site [chemical binding]; other site 754093004191 active site 754093004192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754093004193 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 754093004194 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 754093004195 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 754093004196 signal transduction protein PmrD; Provisional; Region: PRK15450 754093004197 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 754093004198 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 754093004199 acyl-activating enzyme (AAE) consensus motif; other site 754093004200 putative AMP binding site [chemical binding]; other site 754093004201 putative active site [active] 754093004202 putative CoA binding site [chemical binding]; other site 754093004203 O-succinylbenzoate synthase; Provisional; Region: PRK05105 754093004204 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 754093004205 active site 754093004206 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 754093004207 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 754093004208 substrate binding site [chemical binding]; other site 754093004209 oxyanion hole (OAH) forming residues; other site 754093004210 trimer interface [polypeptide binding]; other site 754093004211 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 754093004212 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 754093004213 catalytic site [active] 754093004214 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 754093004215 isochorismate synthases; Region: isochor_syn; TIGR00543 754093004216 hypothetical protein; Provisional; Region: PRK10404 754093004217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754093004218 Coenzyme A binding pocket [chemical binding]; other site 754093004219 ribonuclease BN; Region: true_RNase_BN; TIGR02649 754093004220 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 754093004221 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 754093004222 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 754093004223 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 754093004224 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 754093004225 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 754093004226 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 754093004227 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 754093004228 4Fe-4S binding domain; Region: Fer4; pfam00037 754093004229 4Fe-4S binding domain; Region: Fer4; pfam00037 754093004230 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 754093004231 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 754093004232 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754093004233 catalytic loop [active] 754093004234 iron binding site [ion binding]; other site 754093004235 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 754093004236 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 754093004237 [4Fe-4S] binding site [ion binding]; other site 754093004238 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 754093004239 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 754093004240 SLBB domain; Region: SLBB; pfam10531 754093004241 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 754093004242 NADH dehydrogenase subunit E; Validated; Region: PRK07539 754093004243 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 754093004244 putative dimer interface [polypeptide binding]; other site 754093004245 [2Fe-2S] cluster binding site [ion binding]; other site 754093004246 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 754093004247 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 754093004248 NADH dehydrogenase subunit D; Validated; Region: PRK06075 754093004249 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 754093004250 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 754093004251 Zn2+ binding site [ion binding]; other site 754093004252 Mg2+ binding site [ion binding]; other site 754093004253 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 754093004254 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 754093004255 TrkA-C domain; Region: TrkA_C; pfam02080 754093004256 TrkA-C domain; Region: TrkA_C; pfam02080 754093004257 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 754093004258 putative phosphatase; Provisional; Region: PRK11587 754093004259 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093004260 motif II; other site 754093004261 hypothetical protein; Validated; Region: PRK05445 754093004262 hypothetical protein; Provisional; Region: PRK01816 754093004263 propionate/acetate kinase; Provisional; Region: PRK12379 754093004264 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 754093004265 phosphate acetyltransferase; Reviewed; Region: PRK05632 754093004266 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 754093004267 DRTGG domain; Region: DRTGG; pfam07085 754093004268 phosphate acetyltransferase; Region: pta; TIGR00651 754093004269 hypothetical protein; Provisional; Region: PRK11588 754093004270 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 754093004271 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 754093004272 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 754093004273 nudix motif; other site 754093004274 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 754093004275 active site 754093004276 metal binding site [ion binding]; metal-binding site 754093004277 homotetramer interface [polypeptide binding]; other site 754093004278 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 754093004279 C-terminal domain interface [polypeptide binding]; other site 754093004280 GSH binding site (G-site) [chemical binding]; other site 754093004281 dimer interface [polypeptide binding]; other site 754093004282 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 754093004283 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 754093004284 C-terminal domain interface [polypeptide binding]; other site 754093004285 GSH binding site (G-site) [chemical binding]; other site 754093004286 dimer interface [polypeptide binding]; other site 754093004287 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 754093004288 N-terminal domain interface [polypeptide binding]; other site 754093004289 putative dimer interface [polypeptide binding]; other site 754093004290 active site 754093004291 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 754093004292 homooctamer interface [polypeptide binding]; other site 754093004293 active site 754093004294 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 754093004295 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 754093004296 putative NAD(P) binding site [chemical binding]; other site 754093004297 putative active site [active] 754093004298 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 754093004299 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 754093004300 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 754093004301 Walker A/P-loop; other site 754093004302 ATP binding site [chemical binding]; other site 754093004303 Q-loop/lid; other site 754093004304 ABC transporter signature motif; other site 754093004305 Walker B; other site 754093004306 D-loop; other site 754093004307 H-loop/switch region; other site 754093004308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093004309 dimer interface [polypeptide binding]; other site 754093004310 conserved gate region; other site 754093004311 putative PBP binding loops; other site 754093004312 ABC-ATPase subunit interface; other site 754093004313 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754093004314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093004315 dimer interface [polypeptide binding]; other site 754093004316 conserved gate region; other site 754093004317 putative PBP binding loops; other site 754093004318 ABC-ATPase subunit interface; other site 754093004319 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 754093004320 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754093004321 substrate binding pocket [chemical binding]; other site 754093004322 membrane-bound complex binding site; other site 754093004323 hinge residues; other site 754093004324 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 754093004325 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754093004326 substrate binding pocket [chemical binding]; other site 754093004327 membrane-bound complex binding site; other site 754093004328 hinge residues; other site 754093004329 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 754093004330 Flavoprotein; Region: Flavoprotein; pfam02441 754093004331 amidophosphoribosyltransferase; Provisional; Region: PRK09246 754093004332 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 754093004333 active site 754093004334 tetramer interface [polypeptide binding]; other site 754093004335 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754093004336 active site 754093004337 colicin V production protein; Provisional; Region: PRK10845 754093004338 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 754093004339 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 754093004340 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 754093004341 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 754093004342 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 754093004343 hypothetical protein; Provisional; Region: PRK10847 754093004344 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 754093004345 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 754093004346 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 754093004347 ligand binding site [chemical binding]; other site 754093004348 NAD binding site [chemical binding]; other site 754093004349 catalytic site [active] 754093004350 homodimer interface [polypeptide binding]; other site 754093004351 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 754093004352 putative transporter; Provisional; Region: PRK12382 754093004353 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 754093004354 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 754093004355 dimer interface [polypeptide binding]; other site 754093004356 active site 754093004357 Uncharacterized conserved protein [Function unknown]; Region: COG4121 754093004358 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 754093004359 YfcL protein; Region: YfcL; pfam08891 754093004360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 754093004361 hypothetical protein; Provisional; Region: PRK10621 754093004362 Predicted permeases [General function prediction only]; Region: COG0730 754093004363 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 754093004364 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 754093004365 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 754093004366 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 754093004367 Tetramer interface [polypeptide binding]; other site 754093004368 active site 754093004369 FMN-binding site [chemical binding]; other site 754093004370 hypothetical protein; Provisional; Region: PRK04946 754093004371 Smr domain; Region: Smr; pfam01713 754093004372 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 754093004373 Fimbrial protein; Region: Fimbrial; cl01416 754093004374 Fimbrial protein; Region: Fimbrial; cl01416 754093004375 Fimbrial protein; Region: Fimbrial; cl01416 754093004376 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 754093004377 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 754093004378 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 754093004379 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 754093004380 PapC C-terminal domain; Region: PapC_C; pfam13953 754093004381 PapC N-terminal domain; Region: PapC_N; pfam13954 754093004382 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 754093004383 Fimbrial protein; Region: Fimbrial; cl01416 754093004384 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754093004385 catalytic core [active] 754093004386 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 754093004387 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 754093004388 substrate binding site [chemical binding]; other site 754093004389 oxyanion hole (OAH) forming residues; other site 754093004390 trimer interface [polypeptide binding]; other site 754093004391 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 754093004392 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 754093004393 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 754093004394 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 754093004395 dimer interface [polypeptide binding]; other site 754093004396 active site 754093004397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 754093004398 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 754093004399 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 754093004400 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 754093004401 fructuronate transporter; Provisional; Region: PRK10034; cl15264 754093004402 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 754093004403 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 754093004404 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754093004405 catalytic residue [active] 754093004406 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 754093004407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093004408 putative substrate translocation pore; other site 754093004409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093004410 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 754093004411 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754093004412 HlyD family secretion protein; Region: HlyD_3; pfam13437 754093004413 putative transporter YfdV; Provisional; Region: PRK09903 754093004414 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 754093004415 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 754093004416 PYR/PP interface [polypeptide binding]; other site 754093004417 dimer interface [polypeptide binding]; other site 754093004418 TPP binding site [chemical binding]; other site 754093004419 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 754093004420 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 754093004421 TPP-binding site; other site 754093004422 dimer interface [polypeptide binding]; other site 754093004423 formyl-coenzyme A transferase; Provisional; Region: PRK05398 754093004424 CoA-transferase family III; Region: CoA_transf_3; pfam02515 754093004425 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 754093004426 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 754093004427 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 754093004428 putative acyl-acceptor binding pocket; other site 754093004429 aminotransferase; Validated; Region: PRK08175 754093004430 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754093004431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093004432 homodimer interface [polypeptide binding]; other site 754093004433 catalytic residue [active] 754093004434 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 754093004435 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 754093004436 GAF domain; Region: GAF; pfam01590 754093004437 Histidine kinase; Region: His_kinase; pfam06580 754093004438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093004439 ATP binding site [chemical binding]; other site 754093004440 Mg2+ binding site [ion binding]; other site 754093004441 G-X-G motif; other site 754093004442 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 754093004443 LytTr DNA-binding domain; Region: LytTR; pfam04397 754093004444 exoaminopeptidase; Provisional; Region: PRK09961 754093004445 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 754093004446 oligomer interface [polypeptide binding]; other site 754093004447 active site 754093004448 metal binding site [ion binding]; metal-binding site 754093004449 aminopeptidase; Provisional; Region: PRK09795 754093004450 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 754093004451 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 754093004452 active site 754093004453 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 754093004454 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 754093004455 active site 754093004456 P-loop; other site 754093004457 phosphorylation site [posttranslational modification] 754093004458 glucokinase, proteobacterial type; Region: glk; TIGR00749 754093004459 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 754093004460 nucleotide binding site [chemical binding]; other site 754093004461 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 754093004462 manganese transport protein MntH; Reviewed; Region: PRK00701 754093004463 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 754093004464 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093004465 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 754093004466 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 754093004467 Nucleoside recognition; Region: Gate; pfam07670 754093004468 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 754093004469 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 754093004470 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754093004471 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 754093004472 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754093004473 salt bridge; other site 754093004474 non-specific DNA binding site [nucleotide binding]; other site 754093004475 sequence-specific DNA binding site [nucleotide binding]; other site 754093004476 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 754093004477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 754093004478 Probable transposase; Region: OrfB_IS605; pfam01385 754093004479 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 754093004480 Transposase IS200 like; Region: Y1_Tnp; pfam01797 754093004481 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 754093004482 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 754093004483 active site 754093004484 HIGH motif; other site 754093004485 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 754093004486 active site 754093004487 KMSKS motif; other site 754093004488 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754093004489 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754093004490 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093004491 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754093004492 dimerization interface [polypeptide binding]; other site 754093004493 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 754093004494 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 754093004495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 754093004496 putative sulfate transport protein CysZ; Validated; Region: PRK04949 754093004497 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 754093004498 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 754093004499 dimer interface [polypeptide binding]; other site 754093004500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093004501 catalytic residue [active] 754093004502 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 754093004503 dimerization domain swap beta strand [polypeptide binding]; other site 754093004504 regulatory protein interface [polypeptide binding]; other site 754093004505 active site 754093004506 regulatory phosphorylation site [posttranslational modification]; other site 754093004507 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 754093004508 HPr interaction site; other site 754093004509 glycerol kinase (GK) interaction site [polypeptide binding]; other site 754093004510 active site 754093004511 phosphorylation site [posttranslational modification] 754093004512 hypothetical protein; Provisional; Region: PRK10318 754093004513 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 754093004514 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 754093004515 Walker A/P-loop; other site 754093004516 ATP binding site [chemical binding]; other site 754093004517 Q-loop/lid; other site 754093004518 ABC transporter signature motif; other site 754093004519 Walker B; other site 754093004520 D-loop; other site 754093004521 H-loop/switch region; other site 754093004522 TOBE-like domain; Region: TOBE_3; pfam12857 754093004523 sulfate transport protein; Provisional; Region: cysT; CHL00187 754093004524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093004525 dimer interface [polypeptide binding]; other site 754093004526 conserved gate region; other site 754093004527 putative PBP binding loops; other site 754093004528 ABC-ATPase subunit interface; other site 754093004529 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 754093004530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093004531 dimer interface [polypeptide binding]; other site 754093004532 conserved gate region; other site 754093004533 putative PBP binding loops; other site 754093004534 ABC-ATPase subunit interface; other site 754093004535 thiosulfate transporter subunit; Provisional; Region: PRK10852 754093004536 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 754093004537 short chain dehydrogenase; Provisional; Region: PRK08226 754093004538 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 754093004539 NAD binding site [chemical binding]; other site 754093004540 homotetramer interface [polypeptide binding]; other site 754093004541 homodimer interface [polypeptide binding]; other site 754093004542 active site 754093004543 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 754093004544 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 754093004545 putative active site [active] 754093004546 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 754093004547 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 754093004548 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 754093004549 active site 754093004550 metal binding site [ion binding]; metal-binding site 754093004551 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 754093004552 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 754093004553 transcriptional regulator EutR; Provisional; Region: PRK10130 754093004554 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093004555 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093004556 carboxysome structural protein EutK; Provisional; Region: PRK15466 754093004557 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 754093004558 Hexamer interface [polypeptide binding]; other site 754093004559 Hexagonal pore residue; other site 754093004560 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 754093004561 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 754093004562 putative hexamer interface [polypeptide binding]; other site 754093004563 putative hexagonal pore; other site 754093004564 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 754093004565 putative hexamer interface [polypeptide binding]; other site 754093004566 putative hexagonal pore; other site 754093004567 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 754093004568 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 754093004569 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 754093004570 Malic enzyme, N-terminal domain; Region: malic; pfam00390 754093004571 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 754093004572 putative NAD(P) binding site [chemical binding]; other site 754093004573 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 754093004574 Class I aldolases; Region: Aldolase_Class_I; cl17187 754093004575 Class I aldolases; Region: Aldolase_Class_I; cl17187 754093004576 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 754093004577 TPP-binding site [chemical binding]; other site 754093004578 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 754093004579 PYR/PP interface [polypeptide binding]; other site 754093004580 dimer interface [polypeptide binding]; other site 754093004581 TPP binding site [chemical binding]; other site 754093004582 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 754093004583 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 754093004584 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 754093004585 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 754093004586 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754093004587 dimerization interface [polypeptide binding]; other site 754093004588 Histidine kinase; Region: HisKA_3; pfam07730 754093004589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093004590 ATP binding site [chemical binding]; other site 754093004591 Mg2+ binding site [ion binding]; other site 754093004592 G-X-G motif; other site 754093004593 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 754093004594 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 754093004595 metal binding site [ion binding]; metal-binding site 754093004596 dimer interface [polypeptide binding]; other site 754093004597 hypothetical protein; Provisional; Region: PRK13664 754093004598 putative hydrolase; Provisional; Region: PRK11460 754093004599 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 754093004600 Helicase; Region: Helicase_RecD; pfam05127 754093004601 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 754093004602 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 754093004603 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 754093004604 lipoprotein; Provisional; Region: PRK11679 754093004605 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 754093004606 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 754093004607 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 754093004608 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 754093004609 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 754093004610 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 754093004611 catalytic triad [active] 754093004612 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 754093004613 4Fe-4S binding domain; Region: Fer4; pfam00037 754093004614 hydrogenase 4 subunit B; Validated; Region: PRK06521 754093004615 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 754093004616 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 754093004617 NADH dehydrogenase; Region: NADHdh; cl00469 754093004618 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 754093004619 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 754093004620 hydrogenase 4 subunit F; Validated; Region: PRK06458 754093004621 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 754093004622 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 754093004623 putative formate transporter; Provisional; Region: focB; PRK09713 754093004624 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 754093004625 Domain of unknown function DUF20; Region: UPF0118; pfam01594 754093004626 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 754093004627 Peptidase family M48; Region: Peptidase_M48; cl12018 754093004628 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 754093004629 ArsC family; Region: ArsC; pfam03960 754093004630 catalytic residues [active] 754093004631 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 754093004632 DNA replication initiation factor; Provisional; Region: PRK08084 754093004633 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754093004634 active site 754093004635 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 754093004636 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 754093004637 dimerization interface [polypeptide binding]; other site 754093004638 putative ATP binding site [chemical binding]; other site 754093004639 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 754093004640 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 754093004641 active site 754093004642 substrate binding site [chemical binding]; other site 754093004643 cosubstrate binding site; other site 754093004644 catalytic site [active] 754093004645 exopolyphosphatase; Provisional; Region: PRK10854 754093004646 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 754093004647 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093004648 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093004649 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093004650 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093004651 Transposase; Region: HTH_Tnp_1; cl17663 754093004652 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093004653 GMP synthase; Reviewed; Region: guaA; PRK00074 754093004654 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 754093004655 AMP/PPi binding site [chemical binding]; other site 754093004656 candidate oxyanion hole; other site 754093004657 catalytic triad [active] 754093004658 potential glutamine specificity residues [chemical binding]; other site 754093004659 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 754093004660 ATP Binding subdomain [chemical binding]; other site 754093004661 Ligand Binding sites [chemical binding]; other site 754093004662 Dimerization subdomain; other site 754093004663 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 754093004664 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 754093004665 generic binding surface II; other site 754093004666 generic binding surface I; other site 754093004667 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 754093004668 GTP-binding protein Der; Reviewed; Region: PRK00093 754093004669 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 754093004670 G1 box; other site 754093004671 GTP/Mg2+ binding site [chemical binding]; other site 754093004672 Switch I region; other site 754093004673 G2 box; other site 754093004674 Switch II region; other site 754093004675 G3 box; other site 754093004676 G4 box; other site 754093004677 G5 box; other site 754093004678 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 754093004679 G1 box; other site 754093004680 GTP/Mg2+ binding site [chemical binding]; other site 754093004681 Switch I region; other site 754093004682 G2 box; other site 754093004683 G3 box; other site 754093004684 Switch II region; other site 754093004685 G4 box; other site 754093004686 G5 box; other site 754093004687 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 754093004688 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 754093004689 Trp docking motif [polypeptide binding]; other site 754093004690 active site 754093004691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 754093004692 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 754093004693 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 754093004694 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 754093004695 cytoskeletal protein RodZ; Provisional; Region: PRK10856 754093004696 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754093004697 non-specific DNA binding site [nucleotide binding]; other site 754093004698 salt bridge; other site 754093004699 sequence-specific DNA binding site [nucleotide binding]; other site 754093004700 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 754093004701 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 754093004702 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754093004703 FeS/SAM binding site; other site 754093004704 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 754093004705 active site 754093004706 multimer interface [polypeptide binding]; other site 754093004707 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 754093004708 surface patch; other site 754093004709 thioester region; other site 754093004710 specificity defining residues; other site 754093004711 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 754093004712 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 754093004713 active site residue [active] 754093004714 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 754093004715 active site residue [active] 754093004716 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 754093004717 aminopeptidase B; Provisional; Region: PRK05015 754093004718 Peptidase; Region: DUF3663; pfam12404 754093004719 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 754093004720 interface (dimer of trimers) [polypeptide binding]; other site 754093004721 Substrate-binding/catalytic site; other site 754093004722 Zn-binding sites [ion binding]; other site 754093004723 hypothetical protein; Provisional; Region: PRK10721 754093004724 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 754093004725 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754093004726 catalytic loop [active] 754093004727 iron binding site [ion binding]; other site 754093004728 chaperone protein HscA; Provisional; Region: hscA; PRK05183 754093004729 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 754093004730 nucleotide binding site [chemical binding]; other site 754093004731 putative NEF/HSP70 interaction site [polypeptide binding]; other site 754093004732 SBD interface [polypeptide binding]; other site 754093004733 co-chaperone HscB; Provisional; Region: hscB; PRK05014 754093004734 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 754093004735 HSP70 interaction site [polypeptide binding]; other site 754093004736 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 754093004737 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 754093004738 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 754093004739 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 754093004740 trimerization site [polypeptide binding]; other site 754093004741 active site 754093004742 cysteine desulfurase; Provisional; Region: PRK14012 754093004743 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 754093004744 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754093004745 catalytic residue [active] 754093004746 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 754093004747 Rrf2 family protein; Region: rrf2_super; TIGR00738 754093004748 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 754093004749 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 754093004750 active site 754093004751 dimerization interface [polypeptide binding]; other site 754093004752 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 754093004753 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 754093004754 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 754093004755 PRD domain; Region: PRD; pfam00874 754093004756 PRD domain; Region: PRD; pfam00874 754093004757 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 754093004758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093004759 putative substrate translocation pore; other site 754093004760 TPR repeat; Region: TPR_11; pfam13414 754093004761 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754093004762 TPR motif; other site 754093004763 binding surface 754093004764 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 754093004765 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 754093004766 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 754093004767 nucleotide binding site [chemical binding]; other site 754093004768 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 754093004769 Nitrogen regulatory protein P-II; Region: P-II; smart00938 754093004770 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754093004771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754093004772 dimer interface [polypeptide binding]; other site 754093004773 phosphorylation site [posttranslational modification] 754093004774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093004775 ATP binding site [chemical binding]; other site 754093004776 Mg2+ binding site [ion binding]; other site 754093004777 G-X-G motif; other site 754093004778 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 754093004779 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754093004780 substrate binding pocket [chemical binding]; other site 754093004781 membrane-bound complex binding site; other site 754093004782 hinge residues; other site 754093004783 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754093004784 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754093004785 catalytic residue [active] 754093004786 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 754093004787 nucleoside/Zn binding site; other site 754093004788 dimer interface [polypeptide binding]; other site 754093004789 catalytic motif [active] 754093004790 hypothetical protein; Provisional; Region: PRK11590 754093004791 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 754093004792 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 754093004793 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 754093004794 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 754093004795 putative active site [active] 754093004796 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 754093004797 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 754093004798 Chorismate mutase type II; Region: CM_2; cl00693 754093004799 prephenate dehydrogenase; Validated; Region: PRK08507 754093004800 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 754093004801 30S subunit binding site; other site 754093004802 Integrase core domain; Region: rve_3; pfam13683 754093004803 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093004804 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 754093004805 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 754093004806 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 754093004807 RimM N-terminal domain; Region: RimM; pfam01782 754093004808 PRC-barrel domain; Region: PRC; pfam05239 754093004809 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 754093004810 signal recognition particle protein; Provisional; Region: PRK10867 754093004811 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 754093004812 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 754093004813 P loop; other site 754093004814 GTP binding site [chemical binding]; other site 754093004815 Signal peptide binding domain; Region: SRP_SPB; pfam02978 754093004816 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 754093004817 hypothetical protein; Provisional; Region: PRK11573 754093004818 Domain of unknown function DUF21; Region: DUF21; pfam01595 754093004819 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 754093004820 Transporter associated domain; Region: CorC_HlyC; smart01091 754093004821 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 754093004822 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 754093004823 dimer interface [polypeptide binding]; other site 754093004824 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 754093004825 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 754093004826 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 754093004827 recombination and repair protein; Provisional; Region: PRK10869 754093004828 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 754093004829 Walker A/P-loop; other site 754093004830 ATP binding site [chemical binding]; other site 754093004831 Q-loop/lid; other site 754093004832 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 754093004833 Q-loop/lid; other site 754093004834 ABC transporter signature motif; other site 754093004835 Walker B; other site 754093004836 D-loop; other site 754093004837 H-loop/switch region; other site 754093004838 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 754093004839 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 754093004840 hypothetical protein; Validated; Region: PRK01777 754093004841 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 754093004842 putative coenzyme Q binding site [chemical binding]; other site 754093004843 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 754093004844 SmpB-tmRNA interface; other site 754093004845 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 754093004846 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 754093004847 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754093004848 nucleotide binding region [chemical binding]; other site 754093004849 ATP-binding site [chemical binding]; other site 754093004850 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 754093004851 GTPase Era; Reviewed; Region: era; PRK00089 754093004852 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 754093004853 G1 box; other site 754093004854 GTP/Mg2+ binding site [chemical binding]; other site 754093004855 Switch I region; other site 754093004856 G2 box; other site 754093004857 Switch II region; other site 754093004858 G3 box; other site 754093004859 G4 box; other site 754093004860 G5 box; other site 754093004861 KH domain; Region: KH_2; pfam07650 754093004862 signal peptidase I; Provisional; Region: PRK10861 754093004863 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 754093004864 Catalytic site [active] 754093004865 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 754093004866 GTP-binding protein LepA; Provisional; Region: PRK05433 754093004867 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 754093004868 G1 box; other site 754093004869 putative GEF interaction site [polypeptide binding]; other site 754093004870 GTP/Mg2+ binding site [chemical binding]; other site 754093004871 Switch I region; other site 754093004872 G2 box; other site 754093004873 G3 box; other site 754093004874 Switch II region; other site 754093004875 G4 box; other site 754093004876 G5 box; other site 754093004877 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 754093004878 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 754093004879 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 754093004880 SoxR reducing system protein RseC; Provisional; Region: PRK10862 754093004881 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 754093004882 anti-sigma E factor; Provisional; Region: rseB; PRK09455 754093004883 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 754093004884 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 754093004885 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 754093004886 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 754093004887 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754093004888 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754093004889 DNA binding residues [nucleotide binding] 754093004890 L-aspartate oxidase; Provisional; Region: PRK09077 754093004891 L-aspartate oxidase; Provisional; Region: PRK06175 754093004892 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 754093004893 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 754093004894 Methyltransferase domain; Region: Methyltransf_26; pfam13659 754093004895 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 754093004896 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 754093004897 ATP binding site [chemical binding]; other site 754093004898 Mg++ binding site [ion binding]; other site 754093004899 motif III; other site 754093004900 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754093004901 nucleotide binding region [chemical binding]; other site 754093004902 ATP-binding site [chemical binding]; other site 754093004903 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754093004904 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093004905 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 754093004906 dimerization interface [polypeptide binding]; other site 754093004907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 754093004908 HTH-like domain; Region: HTH_21; pfam13276 754093004909 Integrase core domain; Region: rve; pfam00665 754093004910 Integrase core domain; Region: rve_2; pfam13333 754093004911 LysE type translocator; Region: LysE; cl00565 754093004912 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 754093004913 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 754093004914 ligand binding site [chemical binding]; other site 754093004915 active site 754093004916 UGI interface [polypeptide binding]; other site 754093004917 catalytic site [active] 754093004918 thioredoxin 2; Provisional; Region: PRK10996 754093004919 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 754093004920 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 754093004921 catalytic residues [active] 754093004922 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 754093004923 CoA binding domain; Region: CoA_binding_2; pfam13380 754093004924 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 754093004925 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 754093004926 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 754093004927 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 754093004928 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 754093004929 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 754093004930 domain interface [polypeptide binding]; other site 754093004931 putative active site [active] 754093004932 catalytic site [active] 754093004933 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 754093004934 domain interface [polypeptide binding]; other site 754093004935 putative active site [active] 754093004936 catalytic site [active] 754093004937 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 754093004938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093004939 putative substrate translocation pore; other site 754093004940 hypothetical protein; Provisional; Region: PRK10723 754093004941 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 754093004942 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 754093004943 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754093004944 RNA binding surface [nucleotide binding]; other site 754093004945 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 754093004946 active site 754093004947 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 754093004948 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 754093004949 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 754093004950 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 754093004951 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 754093004952 Transposase; Region: HTH_Tnp_1; pfam01527 754093004953 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093004954 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 754093004955 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 754093004956 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 754093004957 Integrase core domain; Region: rve; pfam00665 754093004958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093004959 Transposase; Region: HTH_Tnp_1; cl17663 754093004960 Integrase core domain; Region: rve; pfam00665 754093004961 HTH-like domain; Region: HTH_21; pfam13276 754093004962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093004963 Transposase; Region: HTH_Tnp_1; cl17663 754093004964 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093004965 Transposase; Region: HTH_Tnp_1; cl17663 754093004966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093004967 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093004968 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 754093004969 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 754093004970 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754093004971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093004972 catalytic residue [active] 754093004973 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 754093004974 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 754093004975 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754093004976 DNA-binding site [nucleotide binding]; DNA binding site 754093004977 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 754093004978 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 754093004979 bacterial OsmY and nodulation domain; Region: BON; smart00749 754093004980 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 754093004981 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 754093004982 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754093004983 dimerization interface [polypeptide binding]; other site 754093004984 putative DNA binding site [nucleotide binding]; other site 754093004985 putative Zn2+ binding site [ion binding]; other site 754093004986 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 754093004987 active site residue [active] 754093004988 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 754093004989 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 754093004990 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 754093004991 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 754093004992 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093004993 hypothetical protein; Provisional; Region: PRK10556 754093004994 hypothetical protein; Provisional; Region: PRK10132 754093004995 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 754093004996 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754093004997 DNA-binding site [nucleotide binding]; DNA binding site 754093004998 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754093004999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093005000 homodimer interface [polypeptide binding]; other site 754093005001 catalytic residue [active] 754093005002 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 754093005003 Uncharacterized conserved protein [Function unknown]; Region: COG2128 754093005004 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 754093005005 catalytic residues [active] 754093005006 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 754093005007 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 754093005008 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 754093005009 Class I ribonucleotide reductase; Region: RNR_I; cd01679 754093005010 active site 754093005011 dimer interface [polypeptide binding]; other site 754093005012 catalytic residues [active] 754093005013 effector binding site; other site 754093005014 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 754093005015 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093005016 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 754093005017 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 754093005018 Walker A/P-loop; other site 754093005019 ATP binding site [chemical binding]; other site 754093005020 Q-loop/lid; other site 754093005021 ABC transporter signature motif; other site 754093005022 Walker B; other site 754093005023 D-loop; other site 754093005024 H-loop/switch region; other site 754093005025 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 754093005026 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 754093005027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093005028 dimer interface [polypeptide binding]; other site 754093005029 conserved gate region; other site 754093005030 putative PBP binding loops; other site 754093005031 ABC-ATPase subunit interface; other site 754093005032 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093005033 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 754093005034 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 754093005035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093005036 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 754093005037 putative L-valine exporter; Provisional; Region: PRK10408 754093005038 transcriptional repressor MprA; Provisional; Region: PRK10870 754093005039 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 754093005040 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 754093005041 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 754093005042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093005043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093005044 RNA ligase; Region: RNA_ligase; pfam09414 754093005045 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 754093005046 Zn2+ binding site [ion binding]; other site 754093005047 Mg2+ binding site [ion binding]; other site 754093005048 AAA domain; Region: AAA_33; pfam13671 754093005049 S-ribosylhomocysteinase; Provisional; Region: PRK02260 754093005050 glutamate--cysteine ligase; Provisional; Region: PRK02107 754093005051 Predicted membrane protein [Function unknown]; Region: COG1238 754093005052 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 754093005053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093005054 motif II; other site 754093005055 carbon storage regulator; Provisional; Region: PRK01712 754093005056 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 754093005057 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 754093005058 motif 1; other site 754093005059 active site 754093005060 motif 2; other site 754093005061 motif 3; other site 754093005062 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 754093005063 DHHA1 domain; Region: DHHA1; pfam02272 754093005064 recombination regulator RecX; Reviewed; Region: recX; PRK00117 754093005065 recombinase A; Provisional; Region: recA; PRK09354 754093005066 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 754093005067 hexamer interface [polypeptide binding]; other site 754093005068 Walker A motif; other site 754093005069 ATP binding site [chemical binding]; other site 754093005070 Walker B motif; other site 754093005071 Transglycosylase SLT domain; Region: SLT_2; pfam13406 754093005072 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754093005073 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754093005074 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 754093005075 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 754093005076 Nucleoside recognition; Region: Gate; pfam07670 754093005077 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093005078 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 754093005079 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 754093005080 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 754093005081 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 754093005082 putative NAD(P) binding site [chemical binding]; other site 754093005083 active site 754093005084 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 754093005085 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 754093005086 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 754093005087 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754093005088 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 754093005089 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 754093005090 putative active site [active] 754093005091 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 754093005092 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 754093005093 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 754093005094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754093005095 Walker A motif; other site 754093005096 ATP binding site [chemical binding]; other site 754093005097 Walker B motif; other site 754093005098 arginine finger; other site 754093005099 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 754093005100 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 754093005101 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 754093005102 Rubredoxin [Energy production and conversion]; Region: COG1773 754093005103 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 754093005104 iron binding site [ion binding]; other site 754093005105 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 754093005106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754093005107 Acylphosphatase; Region: Acylphosphatase; pfam00708 754093005108 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 754093005109 HypF finger; Region: zf-HYPF; pfam07503 754093005110 HypF finger; Region: zf-HYPF; pfam07503 754093005111 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 754093005112 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 754093005113 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 754093005114 Transcriptional regulators [Transcription]; Region: PurR; COG1609 754093005115 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754093005116 DNA binding site [nucleotide binding] 754093005117 domain linker motif; other site 754093005118 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 754093005119 dimerization interface (closed form) [polypeptide binding]; other site 754093005120 ligand binding site [chemical binding]; other site 754093005121 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 754093005122 active site turn [active] 754093005123 phosphorylation site [posttranslational modification] 754093005124 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl17885 754093005125 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 754093005126 beta-galactosidase; Region: BGL; TIGR03356 754093005127 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 754093005128 nickel binding site [ion binding]; other site 754093005129 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 754093005130 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 754093005131 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 754093005132 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 754093005133 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 754093005134 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 754093005135 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 754093005136 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 754093005137 NADH dehydrogenase; Region: NADHdh; cl00469 754093005138 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 754093005139 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 754093005140 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 754093005141 hydrogenase assembly chaperone; Provisional; Region: PRK10409 754093005142 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 754093005143 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 754093005144 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 754093005145 dimerization interface [polypeptide binding]; other site 754093005146 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 754093005147 ATP binding site [chemical binding]; other site 754093005148 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 754093005149 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 754093005150 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 754093005151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754093005152 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 754093005153 Walker A motif; other site 754093005154 ATP binding site [chemical binding]; other site 754093005155 Walker B motif; other site 754093005156 arginine finger; other site 754093005157 Integrase core domain; Region: rve_3; pfam13683 754093005158 Transposase; Region: HTH_Tnp_1; cl17663 754093005159 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 754093005160 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 754093005161 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 754093005162 MutS domain I; Region: MutS_I; pfam01624 754093005163 MutS domain II; Region: MutS_II; pfam05188 754093005164 MutS domain III; Region: MutS_III; pfam05192 754093005165 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 754093005166 Walker A/P-loop; other site 754093005167 ATP binding site [chemical binding]; other site 754093005168 Q-loop/lid; other site 754093005169 ABC transporter signature motif; other site 754093005170 Walker B; other site 754093005171 D-loop; other site 754093005172 H-loop/switch region; other site 754093005173 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 754093005174 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 754093005175 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 754093005176 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 754093005177 Flavoprotein; Region: Flavoprotein; pfam02441 754093005178 MarR family; Region: MarR_2; cl17246 754093005179 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 754093005180 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 754093005181 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 754093005182 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754093005183 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 754093005184 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754093005185 DNA binding residues [nucleotide binding] 754093005186 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 754093005187 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 754093005188 Peptidase family M23; Region: Peptidase_M23; pfam01551 754093005189 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 754093005190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093005191 S-adenosylmethionine binding site [chemical binding]; other site 754093005192 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 754093005193 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 754093005194 Permutation of conserved domain; other site 754093005195 active site 754093005196 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 754093005197 homotrimer interaction site [polypeptide binding]; other site 754093005198 zinc binding site [ion binding]; other site 754093005199 CDP-binding sites; other site 754093005200 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 754093005201 substrate binding site; other site 754093005202 dimer interface; other site 754093005203 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 754093005204 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 754093005205 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 754093005206 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 754093005207 ligand-binding site [chemical binding]; other site 754093005208 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 754093005209 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 754093005210 CysD dimerization site [polypeptide binding]; other site 754093005211 G1 box; other site 754093005212 putative GEF interaction site [polypeptide binding]; other site 754093005213 GTP/Mg2+ binding site [chemical binding]; other site 754093005214 Switch I region; other site 754093005215 G2 box; other site 754093005216 G3 box; other site 754093005217 Switch II region; other site 754093005218 G4 box; other site 754093005219 G5 box; other site 754093005220 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 754093005221 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 754093005222 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 754093005223 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 754093005224 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 754093005225 Active Sites [active] 754093005226 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 754093005227 metal binding site [ion binding]; metal-binding site 754093005228 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 754093005229 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 754093005230 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 754093005231 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 754093005232 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 754093005233 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093005234 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093005235 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093005236 Integrase core domain; Region: rve; pfam00665 754093005237 Integrase core domain; Region: rve_3; cl15866 754093005238 HTH-like domain; Region: HTH_21; pfam13276 754093005239 Integrase core domain; Region: rve; pfam00665 754093005240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 754093005241 HTH-like domain; Region: HTH_21; pfam13276 754093005242 Integrase core domain; Region: rve; pfam00665 754093005243 Integrase core domain; Region: rve_2; pfam13333 754093005244 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 754093005245 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 754093005246 Active Sites [active] 754093005247 sulfite reductase subunit beta; Provisional; Region: PRK13504 754093005248 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 754093005249 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 754093005250 Flavodoxin; Region: Flavodoxin_1; pfam00258 754093005251 FAD binding domain; Region: FAD_binding_1; pfam00667 754093005252 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 754093005253 FAD binding pocket [chemical binding]; other site 754093005254 conserved FAD binding motif [chemical binding]; other site 754093005255 phosphate binding motif [ion binding]; other site 754093005256 beta-alpha-beta structure motif; other site 754093005257 NAD binding pocket [chemical binding]; other site 754093005258 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 754093005259 homohexamer interface [polypeptide binding]; other site 754093005260 putative substrate stabilizing pore; other site 754093005261 pterin binding site; other site 754093005262 putative oxidoreductase FixC; Provisional; Region: PRK10157 754093005263 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 754093005264 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 754093005265 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 754093005266 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 754093005267 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 754093005268 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 754093005269 Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086 754093005270 Ligand Binding Site [chemical binding]; other site 754093005271 Electron transfer flavoprotein domain; Region: ETF; pfam01012 754093005272 benzoate transport; Region: 2A0115; TIGR00895 754093005273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093005274 putative substrate translocation pore; other site 754093005275 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 754093005276 FAD binding domain; Region: FAD_binding_4; pfam01565 754093005277 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093005278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093005279 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093005280 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093005281 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 754093005282 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 754093005283 NADP binding site [chemical binding]; other site 754093005284 homodimer interface [polypeptide binding]; other site 754093005285 active site 754093005286 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754093005287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093005288 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 754093005289 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 754093005290 nucleotide binding site [chemical binding]; other site 754093005291 Integrase core domain; Region: rve; pfam00665 754093005292 Integrase core domain; Region: rve_3; pfam13683 754093005293 Transposase; Region: HTH_Tnp_1; cl17663 754093005294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093005295 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 754093005296 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 754093005297 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 754093005298 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 754093005299 HTH-like domain; Region: HTH_21; pfam13276 754093005300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 754093005301 HTH-like domain; Region: HTH_21; pfam13276 754093005302 Integrase core domain; Region: rve; pfam00665 754093005303 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 754093005304 Repair protein; Region: Repair_PSII; pfam04536 754093005305 enolase; Provisional; Region: eno; PRK00077 754093005306 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 754093005307 dimer interface [polypeptide binding]; other site 754093005308 metal binding site [ion binding]; metal-binding site 754093005309 substrate binding pocket [chemical binding]; other site 754093005310 CTP synthetase; Validated; Region: pyrG; PRK05380 754093005311 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 754093005312 Catalytic site [active] 754093005313 active site 754093005314 UTP binding site [chemical binding]; other site 754093005315 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 754093005316 active site 754093005317 putative oxyanion hole; other site 754093005318 catalytic triad [active] 754093005319 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 754093005320 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 754093005321 homodimer interface [polypeptide binding]; other site 754093005322 metal binding site [ion binding]; metal-binding site 754093005323 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 754093005324 homodimer interface [polypeptide binding]; other site 754093005325 active site 754093005326 putative chemical substrate binding site [chemical binding]; other site 754093005327 metal binding site [ion binding]; metal-binding site 754093005328 toxin MazF; Provisional; Region: PRK09907 754093005329 antitoxin MazE; Provisional; Region: PRK09798 754093005330 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 754093005331 HD domain; Region: HD_4; pfam13328 754093005332 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 754093005333 synthetase active site [active] 754093005334 NTP binding site [chemical binding]; other site 754093005335 metal binding site [ion binding]; metal-binding site 754093005336 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 754093005337 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 754093005338 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 754093005339 TRAM domain; Region: TRAM; pfam01938 754093005340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093005341 S-adenosylmethionine binding site [chemical binding]; other site 754093005342 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 754093005343 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754093005344 dimerization interface [polypeptide binding]; other site 754093005345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754093005346 dimer interface [polypeptide binding]; other site 754093005347 phosphorylation site [posttranslational modification] 754093005348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093005349 ATP binding site [chemical binding]; other site 754093005350 Mg2+ binding site [ion binding]; other site 754093005351 G-X-G motif; other site 754093005352 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 754093005353 Response regulator receiver domain; Region: Response_reg; pfam00072 754093005354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093005355 active site 754093005356 phosphorylation site [posttranslational modification] 754093005357 intermolecular recognition site; other site 754093005358 dimerization interface [polypeptide binding]; other site 754093005359 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 754093005360 putative binding surface; other site 754093005361 active site 754093005362 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 754093005363 substrate binding pocket [chemical binding]; other site 754093005364 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 754093005365 metal binding site [ion binding]; metal-binding site 754093005366 substrate binding pocket [chemical binding]; other site 754093005367 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 754093005368 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 754093005369 metal binding site [ion binding]; metal-binding site 754093005370 substrate binding pocket [chemical binding]; other site 754093005371 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 754093005372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093005373 putative substrate translocation pore; other site 754093005374 D-galactonate transporter; Region: 2A0114; TIGR00893 754093005375 flavodoxin; Provisional; Region: PRK08105 754093005376 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 754093005377 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 754093005378 probable active site [active] 754093005379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 754093005380 SecY interacting protein Syd; Provisional; Region: PRK04968 754093005381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 754093005382 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 754093005383 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 754093005384 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 754093005385 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 754093005386 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 754093005387 serine transporter; Region: stp; TIGR00814 754093005388 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 754093005389 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 754093005390 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 754093005391 flap endonuclease-like protein; Provisional; Region: PRK09482 754093005392 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 754093005393 active site 754093005394 metal binding site 1 [ion binding]; metal-binding site 754093005395 putative 5' ssDNA interaction site; other site 754093005396 metal binding site 3; metal-binding site 754093005397 metal binding site 2 [ion binding]; metal-binding site 754093005398 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 754093005399 putative DNA binding site [nucleotide binding]; other site 754093005400 putative metal binding site [ion binding]; other site 754093005401 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 754093005402 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 754093005403 dimer interface [polypeptide binding]; other site 754093005404 active site 754093005405 metal binding site [ion binding]; metal-binding site 754093005406 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 754093005407 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 754093005408 intersubunit interface [polypeptide binding]; other site 754093005409 active site 754093005410 Zn2+ binding site [ion binding]; other site 754093005411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093005412 putative substrate translocation pore; other site 754093005413 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093005414 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093005415 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093005416 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093005417 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093005418 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093005419 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093005420 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093005421 L-fucose transporter; Provisional; Region: PRK10133; cl17665 754093005422 L-fucose isomerase; Provisional; Region: fucI; PRK10991 754093005423 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 754093005424 hexamer (dimer of trimers) interface [polypeptide binding]; other site 754093005425 trimer interface [polypeptide binding]; other site 754093005426 substrate binding site [chemical binding]; other site 754093005427 Mn binding site [ion binding]; other site 754093005428 L-fuculokinase; Provisional; Region: PRK10331 754093005429 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 754093005430 nucleotide binding site [chemical binding]; other site 754093005431 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 754093005432 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 754093005433 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 754093005434 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 754093005435 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093005436 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 754093005437 dimerization interface [polypeptide binding]; other site 754093005438 substrate binding pocket [chemical binding]; other site 754093005439 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 754093005440 CsdA-binding activator; Provisional; Region: PRK15019 754093005441 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 754093005442 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 754093005443 putative ATP binding site [chemical binding]; other site 754093005444 putative substrate interface [chemical binding]; other site 754093005445 murein transglycosylase A; Provisional; Region: mltA; PRK11162 754093005446 MltA specific insert domain; Region: MltA; pfam03562 754093005447 3D domain; Region: 3D; pfam06725 754093005448 AMIN domain; Region: AMIN; pfam11741 754093005449 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 754093005450 active site 754093005451 metal binding site [ion binding]; metal-binding site 754093005452 N-acetylglutamate synthase; Validated; Region: PRK05279 754093005453 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 754093005454 putative feedback inhibition sensing region; other site 754093005455 putative nucleotide binding site [chemical binding]; other site 754093005456 putative substrate binding site [chemical binding]; other site 754093005457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754093005458 Coenzyme A binding pocket [chemical binding]; other site 754093005459 AAA domain; Region: AAA_30; pfam13604 754093005460 AAA domain; Region: AAA_22; pfam13401 754093005461 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 754093005462 protease3; Provisional; Region: PRK15101 754093005463 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 754093005464 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 754093005465 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 754093005466 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 754093005467 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 754093005468 hypothetical protein; Provisional; Region: PRK10332 754093005469 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 754093005470 hypothetical protein; Provisional; Region: PRK11521 754093005471 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 754093005472 hypothetical protein; Provisional; Region: PRK10557 754093005473 hypothetical protein; Provisional; Region: PRK10506 754093005474 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 754093005475 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 754093005476 active site 754093005477 dimerization interface [polypeptide binding]; other site 754093005478 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 754093005479 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 754093005480 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 754093005481 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 754093005482 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 754093005483 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 754093005484 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 754093005485 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 754093005486 putative active site [active] 754093005487 Ap4A binding site [chemical binding]; other site 754093005488 nudix motif; other site 754093005489 putative metal binding site [ion binding]; other site 754093005490 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 754093005491 putative DNA-binding cleft [nucleotide binding]; other site 754093005492 putative DNA clevage site; other site 754093005493 molecular lever; other site 754093005494 Integral membrane protein TerC family; Region: TerC; cl10468 754093005495 Integral membrane protein TerC family; Region: TerC; cl10468 754093005496 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 754093005497 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754093005498 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754093005499 active site 754093005500 catalytic tetrad [active] 754093005501 lysophospholipid transporter LplT; Provisional; Region: PRK11195 754093005502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093005503 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 754093005504 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 754093005505 putative acyl-acceptor binding pocket; other site 754093005506 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 754093005507 acyl-activating enzyme (AAE) consensus motif; other site 754093005508 putative AMP binding site [chemical binding]; other site 754093005509 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 754093005510 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754093005511 DNA binding site [nucleotide binding] 754093005512 domain linker motif; other site 754093005513 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 754093005514 dimerization interface (closed form) [polypeptide binding]; other site 754093005515 ligand binding site [chemical binding]; other site 754093005516 diaminopimelate decarboxylase; Provisional; Region: PRK11165 754093005517 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 754093005518 active site 754093005519 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754093005520 substrate binding site [chemical binding]; other site 754093005521 catalytic residues [active] 754093005522 dimer interface [polypeptide binding]; other site 754093005523 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 754093005524 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093005525 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 754093005526 putative dimerization interface [polypeptide binding]; other site 754093005527 putative racemase; Provisional; Region: PRK10200 754093005528 aspartate racemase; Region: asp_race; TIGR00035 754093005529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093005530 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 754093005531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093005532 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093005533 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093005534 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093005535 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754093005536 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754093005537 active site 754093005538 catalytic tetrad [active] 754093005539 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 754093005540 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 754093005541 dimer interface [polypeptide binding]; other site 754093005542 active site 754093005543 metal binding site [ion binding]; metal-binding site 754093005544 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 754093005545 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 754093005546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093005547 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093005548 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 754093005549 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 754093005550 biopolymer transport protein ExbB; Provisional; Region: PRK10414 754093005551 biopolymer transport protein ExbD; Provisional; Region: PRK11267 754093005552 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 754093005553 oxidoreductase; Provisional; Region: PRK07985 754093005554 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 754093005555 NAD binding site [chemical binding]; other site 754093005556 metal binding site [ion binding]; metal-binding site 754093005557 active site 754093005558 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 754093005559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093005560 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093005561 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093005562 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754093005563 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754093005564 active site 754093005565 catalytic tetrad [active] 754093005566 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 754093005567 Dienelactone hydrolase family; Region: DLH; pfam01738 754093005568 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 754093005569 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 754093005570 hydrogenase 2 small subunit; Provisional; Region: PRK10468 754093005571 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 754093005572 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 754093005573 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 754093005574 4Fe-4S binding domain; Region: Fer4_6; pfam12837 754093005575 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 754093005576 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 754093005577 hydrogenase 2 large subunit; Provisional; Region: PRK10467 754093005578 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 754093005579 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 754093005580 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 754093005581 putative substrate-binding site; other site 754093005582 nickel binding site [ion binding]; other site 754093005583 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 754093005584 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 754093005585 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 754093005586 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 754093005587 putative S-transferase; Provisional; Region: PRK11752 754093005588 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 754093005589 C-terminal domain interface [polypeptide binding]; other site 754093005590 GSH binding site (G-site) [chemical binding]; other site 754093005591 dimer interface [polypeptide binding]; other site 754093005592 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 754093005593 dimer interface [polypeptide binding]; other site 754093005594 N-terminal domain interface [polypeptide binding]; other site 754093005595 active site 754093005596 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 754093005597 CHAP domain; Region: CHAP; pfam05257 754093005598 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 754093005599 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 754093005600 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 754093005601 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 754093005602 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 754093005603 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 754093005604 TMP-binding site; other site 754093005605 ATP-binding site [chemical binding]; other site 754093005606 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 754093005607 active site 754093005608 CoA binding site [chemical binding]; other site 754093005609 AMP binding site [chemical binding]; other site 754093005610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754093005611 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754093005612 NAD(P) binding site [chemical binding]; other site 754093005613 active site 754093005614 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093005615 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093005616 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093005617 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093005618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093005619 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093005620 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093005621 type II secretion system protein D; Region: type_II_gspD; TIGR02517 754093005622 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 754093005623 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 754093005624 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 754093005625 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 754093005626 type II secretion system protein E; Region: type_II_gspE; TIGR02533 754093005627 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 754093005628 Walker A motif; other site 754093005629 ATP binding site [chemical binding]; other site 754093005630 Walker B motif; other site 754093005631 type II secretion system protein F; Region: GspF; TIGR02120 754093005632 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 754093005633 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 754093005634 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 754093005635 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 754093005636 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 754093005637 type II secretion system protein I; Region: gspI; TIGR01707 754093005638 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 754093005639 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 754093005640 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 754093005641 GspL-like protein; Provisional; Region: PRK09662 754093005642 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 754093005643 YaaC-like Protein; Region: YaaC; pfam14175 754093005644 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093005645 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093005646 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093005647 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 754093005648 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 754093005649 ornithine decarboxylase; Provisional; Region: PRK13578 754093005650 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 754093005651 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 754093005652 homodimer interface [polypeptide binding]; other site 754093005653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093005654 catalytic residue [active] 754093005655 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 754093005656 nucleoside transporter; Region: 2A0110; TIGR00889 754093005657 murein transglycosylase C; Provisional; Region: mltC; PRK11671 754093005658 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 754093005659 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754093005660 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754093005661 catalytic residue [active] 754093005662 oxidative damage protection protein; Provisional; Region: PRK05408 754093005663 adenine DNA glycosylase; Provisional; Region: PRK10880 754093005664 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 754093005665 minor groove reading motif; other site 754093005666 helix-hairpin-helix signature motif; other site 754093005667 substrate binding pocket [chemical binding]; other site 754093005668 active site 754093005669 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 754093005670 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 754093005671 DNA binding and oxoG recognition site [nucleotide binding] 754093005672 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 754093005673 hypothetical protein; Provisional; Region: PRK11702 754093005674 hypothetical protein; Provisional; Region: PRK10626 754093005675 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 754093005676 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 754093005677 homodimer interface [polypeptide binding]; other site 754093005678 active site 754093005679 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 754093005680 HemN family oxidoreductase; Provisional; Region: PRK05660 754093005681 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754093005682 FeS/SAM binding site; other site 754093005683 HemN C-terminal domain; Region: HemN_C; pfam06969 754093005684 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 754093005685 putative active site [active] 754093005686 hypothetical protein; Validated; Region: PRK05090 754093005687 YGGT family; Region: YGGT; pfam02325 754093005688 YGGT family; Region: YGGT; pfam02325 754093005689 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 754093005690 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754093005691 catalytic residue [active] 754093005692 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 754093005693 hypothetical protein; Validated; Region: PRK00228 754093005694 glutathione synthetase; Provisional; Region: PRK05246 754093005695 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 754093005696 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 754093005697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 754093005698 RNA methyltransferase, RsmE family; Region: TIGR00046 754093005699 DNA-specific endonuclease I; Provisional; Region: PRK15137 754093005700 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 754093005701 hypothetical protein; Provisional; Region: PRK04860 754093005702 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 754093005703 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 754093005704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093005705 putative substrate translocation pore; other site 754093005706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093005707 S-adenosylmethionine synthetase; Validated; Region: PRK05250 754093005708 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 754093005709 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 754093005710 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 754093005711 Virulence promoting factor; Region: YqgB; pfam11036 754093005712 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 754093005713 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 754093005714 dimer interface [polypeptide binding]; other site 754093005715 active site 754093005716 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754093005717 catalytic residues [active] 754093005718 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 754093005719 lipoprotein NlpI; Provisional; Region: PRK11189 754093005720 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093005721 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093005722 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 754093005723 agmatinase; Region: agmatinase; TIGR01230 754093005724 oligomer interface [polypeptide binding]; other site 754093005725 putative active site [active] 754093005726 Mn binding site [ion binding]; other site 754093005727 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 754093005728 transketolase; Reviewed; Region: PRK12753 754093005729 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 754093005730 TPP-binding site [chemical binding]; other site 754093005731 dimer interface [polypeptide binding]; other site 754093005732 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 754093005733 PYR/PP interface [polypeptide binding]; other site 754093005734 dimer interface [polypeptide binding]; other site 754093005735 TPP binding site [chemical binding]; other site 754093005736 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 754093005737 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 754093005738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093005739 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093005740 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 754093005741 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 754093005742 active site 754093005743 phosphorylation site [posttranslational modification] 754093005744 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 754093005745 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 754093005746 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 754093005747 active site 754093005748 P-loop; other site 754093005749 phosphorylation site [posttranslational modification] 754093005750 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 754093005751 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 754093005752 putative NAD(P) binding site [chemical binding]; other site 754093005753 catalytic Zn binding site [ion binding]; other site 754093005754 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 754093005755 active site 754093005756 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 754093005757 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 754093005758 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 754093005759 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 754093005760 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 754093005761 active site 754093005762 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093005763 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 754093005764 ABC transporter signature motif; other site 754093005765 Walker B; other site 754093005766 D-loop; other site 754093005767 H-loop/switch region; other site 754093005768 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 754093005769 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 754093005770 trimer interface [polypeptide binding]; other site 754093005771 putative Zn binding site [ion binding]; other site 754093005772 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 754093005773 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 754093005774 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 754093005775 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 754093005776 intersubunit interface [polypeptide binding]; other site 754093005777 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 754093005778 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 754093005779 active site 754093005780 zinc binding site [ion binding]; other site 754093005781 Na+ binding site [ion binding]; other site 754093005782 mechanosensitive channel MscS; Provisional; Region: PRK10334 754093005783 Mechanosensitive ion channel; Region: MS_channel; pfam00924 754093005784 arginine exporter protein; Provisional; Region: PRK09304 754093005785 Uncharacterized conserved protein [Function unknown]; Region: COG2968 754093005786 oxidative stress defense protein; Provisional; Region: PRK11087 754093005787 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093005788 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 754093005789 membrane ATPase/protein kinase; Provisional; Region: PRK09435 754093005790 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 754093005791 Walker A; other site 754093005792 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 754093005793 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 754093005794 B12 binding site [chemical binding]; other site 754093005795 cobalt ligand [ion binding]; other site 754093005796 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 754093005797 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 754093005798 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093005799 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 754093005800 putative dimerization interface [polypeptide binding]; other site 754093005801 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093005802 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754093005803 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 754093005804 tetramer (dimer of dimers) interface [polypeptide binding]; other site 754093005805 active site 754093005806 dimer interface [polypeptide binding]; other site 754093005807 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 754093005808 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 754093005809 ligand binding site [chemical binding]; other site 754093005810 NAD binding site [chemical binding]; other site 754093005811 tetramer interface [polypeptide binding]; other site 754093005812 catalytic site [active] 754093005813 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 754093005814 L-serine binding site [chemical binding]; other site 754093005815 ACT domain interface; other site 754093005816 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 754093005817 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 754093005818 Z-ring-associated protein; Provisional; Region: PRK10972 754093005819 hypothetical protein; Reviewed; Region: PRK01736 754093005820 proline aminopeptidase P II; Provisional; Region: PRK10879 754093005821 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 754093005822 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 754093005823 active site 754093005824 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 754093005825 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 754093005826 oxidoreductase; Provisional; Region: PRK08013 754093005827 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 754093005828 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 754093005829 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754093005830 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 754093005831 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 754093005832 tetramer interface [polypeptide binding]; other site 754093005833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093005834 catalytic residue [active] 754093005835 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 754093005836 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754093005837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754093005838 NAD(P) binding site [chemical binding]; other site 754093005839 classical (c) SDRs; Region: SDR_c; cd05233 754093005840 active site 754093005841 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 754093005842 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 754093005843 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 754093005844 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093005845 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093005846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093005847 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093005848 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093005849 hemolysin; Provisional; Region: PRK15087 754093005850 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 754093005851 putative global regulator; Reviewed; Region: PRK09559 754093005852 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 754093005853 hypothetical protein; Provisional; Region: PRK10878 754093005854 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 754093005855 flavodoxin FldB; Provisional; Region: PRK12359 754093005856 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 754093005857 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 754093005858 active site 754093005859 Int/Topo IB signature motif; other site 754093005860 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 754093005861 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 754093005862 dimerization domain [polypeptide binding]; other site 754093005863 dimer interface [polypeptide binding]; other site 754093005864 catalytic residues [active] 754093005865 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 754093005866 DHH family; Region: DHH; pfam01368 754093005867 DHHA1 domain; Region: DHHA1; pfam02272 754093005868 peptide chain release factor 2; Provisional; Region: PRK08787 754093005869 This domain is found in peptide chain release factors; Region: PCRF; smart00937 754093005870 RF-1 domain; Region: RF-1; pfam00472 754093005871 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 754093005872 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 754093005873 dimer interface [polypeptide binding]; other site 754093005874 putative anticodon binding site; other site 754093005875 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 754093005876 motif 1; other site 754093005877 active site 754093005878 motif 2; other site 754093005879 motif 3; other site 754093005880 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 754093005881 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 754093005882 active site 754093005883 metal binding site [ion binding]; metal-binding site 754093005884 nudix motif; other site 754093005885 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093005886 Transposase; Region: HTH_Tnp_1; pfam01527 754093005887 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 754093005888 HTH-like domain; Region: HTH_21; pfam13276 754093005889 Integrase core domain; Region: rve; pfam00665 754093005890 Integrase core domain; Region: rve_3; cl15866 754093005891 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093005892 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 754093005893 zinc transporter ZupT; Provisional; Region: PRK04201 754093005894 ZIP Zinc transporter; Region: Zip; pfam02535 754093005895 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 754093005896 hypothetical protein; Provisional; Region: PRK11653 754093005897 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 754093005898 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 754093005899 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 754093005900 dimer interface [polypeptide binding]; other site 754093005901 ADP-ribose binding site [chemical binding]; other site 754093005902 active site 754093005903 nudix motif; other site 754093005904 metal binding site [ion binding]; metal-binding site 754093005905 putative dehydrogenase; Provisional; Region: PRK11039 754093005906 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 754093005907 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 754093005908 active site 754093005909 metal binding site [ion binding]; metal-binding site 754093005910 hexamer interface [polypeptide binding]; other site 754093005911 esterase YqiA; Provisional; Region: PRK11071 754093005912 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 754093005913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093005914 ATP binding site [chemical binding]; other site 754093005915 Mg2+ binding site [ion binding]; other site 754093005916 G-X-G motif; other site 754093005917 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 754093005918 anchoring element; other site 754093005919 dimer interface [polypeptide binding]; other site 754093005920 ATP binding site [chemical binding]; other site 754093005921 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 754093005922 active site 754093005923 metal binding site [ion binding]; metal-binding site 754093005924 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 754093005925 Uncharacterized conserved protein [Function unknown]; Region: COG1359 754093005926 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 754093005927 sensor protein QseC; Provisional; Region: PRK10337 754093005928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754093005929 dimer interface [polypeptide binding]; other site 754093005930 phosphorylation site [posttranslational modification] 754093005931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093005932 ATP binding site [chemical binding]; other site 754093005933 Mg2+ binding site [ion binding]; other site 754093005934 G-X-G motif; other site 754093005935 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 754093005936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093005937 active site 754093005938 phosphorylation site [posttranslational modification] 754093005939 intermolecular recognition site; other site 754093005940 dimerization interface [polypeptide binding]; other site 754093005941 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754093005942 DNA binding site [nucleotide binding] 754093005943 TIGR00156 family protein; Region: TIGR00156 754093005944 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 754093005945 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 754093005946 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 754093005947 CAP-like domain; other site 754093005948 active site 754093005949 primary dimer interface [polypeptide binding]; other site 754093005950 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754093005951 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 754093005952 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 754093005953 putative acyl-acceptor binding pocket; other site 754093005954 FtsI repressor; Provisional; Region: PRK10883 754093005955 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 754093005956 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 754093005957 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 754093005958 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 754093005959 putative outer membrane lipoprotein; Provisional; Region: PRK09973 754093005960 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093005961 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093005962 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093005963 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 754093005964 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 754093005965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 754093005966 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 754093005967 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093005968 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093005969 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093005970 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093005971 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093005972 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 754093005973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 754093005974 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 754093005975 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 754093005976 putative ribose interaction site [chemical binding]; other site 754093005977 putative ADP binding site [chemical binding]; other site 754093005978 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 754093005979 active site 754093005980 nucleotide binding site [chemical binding]; other site 754093005981 HIGH motif; other site 754093005982 KMSKS motif; other site 754093005983 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 754093005984 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 754093005985 metal binding triad; other site 754093005986 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 754093005987 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 754093005988 metal binding triad; other site 754093005989 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 754093005990 SH3 domain-containing protein; Provisional; Region: PRK10884 754093005991 Bacterial SH3 domain homologues; Region: SH3b; smart00287 754093005992 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 754093005993 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 754093005994 active site 754093005995 NTP binding site [chemical binding]; other site 754093005996 metal binding triad [ion binding]; metal-binding site 754093005997 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 754093005998 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 754093005999 Zn2+ binding site [ion binding]; other site 754093006000 Mg2+ binding site [ion binding]; other site 754093006001 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 754093006002 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 754093006003 homooctamer interface [polypeptide binding]; other site 754093006004 active site 754093006005 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 754093006006 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754093006007 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093006008 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 754093006009 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 754093006010 Fumarase C-terminus; Region: Fumerase_C; cl00795 754093006011 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 754093006012 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 754093006013 transmembrane helices; other site 754093006014 UGMP family protein; Validated; Region: PRK09604 754093006015 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 754093006016 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 754093006017 DNA primase; Validated; Region: dnaG; PRK05667 754093006018 CHC2 zinc finger; Region: zf-CHC2; pfam01807 754093006019 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 754093006020 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 754093006021 active site 754093006022 metal binding site [ion binding]; metal-binding site 754093006023 interdomain interaction site; other site 754093006024 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 754093006025 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 754093006026 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 754093006027 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 754093006028 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 754093006029 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 754093006030 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754093006031 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 754093006032 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754093006033 DNA binding residues [nucleotide binding] 754093006034 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 754093006035 active site 754093006036 SUMO-1 interface [polypeptide binding]; other site 754093006037 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 754093006038 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 754093006039 FAD binding pocket [chemical binding]; other site 754093006040 FAD binding motif [chemical binding]; other site 754093006041 phosphate binding motif [ion binding]; other site 754093006042 NAD binding pocket [chemical binding]; other site 754093006043 Predicted transcriptional regulators [Transcription]; Region: COG1695 754093006044 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 754093006045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754093006046 PAS domain; Region: PAS_9; pfam13426 754093006047 putative active site [active] 754093006048 heme pocket [chemical binding]; other site 754093006049 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 754093006050 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 754093006051 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 754093006052 dimer interface [polypeptide binding]; other site 754093006053 putative CheW interface [polypeptide binding]; other site 754093006054 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 754093006055 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 754093006056 dimer interface [polypeptide binding]; other site 754093006057 putative tRNA-binding site [nucleotide binding]; other site 754093006058 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 754093006059 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754093006060 DNA binding site [nucleotide binding] 754093006061 domain linker motif; other site 754093006062 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 754093006063 putative dimerization interface [polypeptide binding]; other site 754093006064 putative ligand binding site [chemical binding]; other site 754093006065 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 754093006066 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 754093006067 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 754093006068 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 754093006069 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 754093006070 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093006071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093006072 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093006073 alpha-glucosidase; Provisional; Region: PRK10137 754093006074 Protein of unknown function, DUF608; Region: DUF608; pfam04685 754093006075 Trehalase; Region: Trehalase; cl17346 754093006076 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 754093006077 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 754093006078 active site 754093006079 FMN binding site [chemical binding]; other site 754093006080 2,4-decadienoyl-CoA binding site; other site 754093006081 catalytic residue [active] 754093006082 4Fe-4S cluster binding site [ion binding]; other site 754093006083 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 754093006084 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754093006085 non-specific DNA binding site [nucleotide binding]; other site 754093006086 salt bridge; other site 754093006087 sequence-specific DNA binding site [nucleotide binding]; other site 754093006088 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 754093006089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093006090 S-adenosylmethionine binding site [chemical binding]; other site 754093006091 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 754093006092 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 754093006093 putative active site [active] 754093006094 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 754093006095 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754093006096 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754093006097 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 754093006098 serine/threonine transporter SstT; Provisional; Region: PRK13628 754093006099 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 754093006100 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 754093006101 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 754093006102 galactarate dehydratase; Region: galactar-dH20; TIGR03248 754093006103 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 754093006104 Glucuronate isomerase; Region: UxaC; pfam02614 754093006105 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 754093006106 Glucuronate isomerase; Region: UxaC; cl00829 754093006107 D-galactonate transporter; Region: 2A0114; TIGR00893 754093006108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093006109 putative substrate translocation pore; other site 754093006110 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093006111 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093006112 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 754093006113 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754093006114 DNA-binding site [nucleotide binding]; DNA binding site 754093006115 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 754093006116 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 754093006117 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 754093006118 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 754093006119 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 754093006120 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 754093006121 Predicted membrane protein [Function unknown]; Region: COG5393 754093006122 YqjK-like protein; Region: YqjK; pfam13997 754093006123 Transposase; Region: HTH_Tnp_1; cl17663 754093006124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093006125 Transposase; Region: HTH_Tnp_1; cl17663 754093006126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093006127 Predicted membrane protein [Function unknown]; Region: COG2259 754093006128 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 754093006129 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 754093006130 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 754093006131 putative dimer interface [polypeptide binding]; other site 754093006132 N-terminal domain interface [polypeptide binding]; other site 754093006133 putative substrate binding pocket (H-site) [chemical binding]; other site 754093006134 Predicted membrane protein [Function unknown]; Region: COG3152 754093006135 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 754093006136 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093006137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093006138 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093006139 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093006140 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093006141 Protein of unknown function (DUF805); Region: DUF805; pfam05656 754093006142 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093006143 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 754093006144 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754093006145 dimerization interface [polypeptide binding]; other site 754093006146 Pirin-related protein [General function prediction only]; Region: COG1741 754093006147 Pirin; Region: Pirin; pfam02678 754093006148 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 754093006149 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 754093006150 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 754093006151 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093006152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093006153 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093006154 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093006155 L-serine dehydratase TdcG; Provisional; Region: PRK15040 754093006156 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 754093006157 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 754093006158 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 754093006159 homotrimer interaction site [polypeptide binding]; other site 754093006160 putative active site [active] 754093006161 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 754093006162 Pyruvate formate lyase 1; Region: PFL1; cd01678 754093006163 coenzyme A binding site [chemical binding]; other site 754093006164 active site 754093006165 catalytic residues [active] 754093006166 glycine loop; other site 754093006167 Acetokinase family; Region: Acetate_kinase; cl17229 754093006168 Acetokinase family; Region: Acetate_kinase; cl17229 754093006169 threonine/serine transporter TdcC; Provisional; Region: PRK13629 754093006170 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 754093006171 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 754093006172 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 754093006173 tetramer interface [polypeptide binding]; other site 754093006174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093006175 catalytic residue [active] 754093006176 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 754093006177 putative substrate binding pocket [chemical binding]; other site 754093006178 putative dimerization interface [polypeptide binding]; other site 754093006179 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093006180 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093006181 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093006182 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093006183 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093006184 hypothetical protein; Provisional; Region: PRK09716 754093006185 glycerate kinase I; Provisional; Region: PRK10342 754093006186 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 754093006187 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 754093006188 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 754093006189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 754093006190 D-galactonate transporter; Region: 2A0114; TIGR00893 754093006191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093006192 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093006193 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093006194 Fimbrial protein; Region: Fimbrial; pfam00419 754093006195 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 754093006196 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 754093006197 putative SAM binding site [chemical binding]; other site 754093006198 putative homodimer interface [polypeptide binding]; other site 754093006199 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 754093006200 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 754093006201 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 754093006202 putative ligand binding site [chemical binding]; other site 754093006203 TIGR00252 family protein; Region: TIGR00252 754093006204 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 754093006205 dimer interface [polypeptide binding]; other site 754093006206 active site 754093006207 outer membrane lipoprotein; Provisional; Region: PRK11023 754093006208 BON domain; Region: BON; pfam04972 754093006209 BON domain; Region: BON; pfam04972 754093006210 Predicted permease; Region: DUF318; cl17795 754093006211 Predicted permease; Region: DUF318; cl17795 754093006212 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 754093006213 NADH(P)-binding; Region: NAD_binding_10; pfam13460 754093006214 NAD binding site [chemical binding]; other site 754093006215 active site 754093006216 intracellular protease, PfpI family; Region: PfpI; TIGR01382 754093006217 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 754093006218 proposed catalytic triad [active] 754093006219 conserved cys residue [active] 754093006220 hypothetical protein; Provisional; Region: PRK03467 754093006221 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 754093006222 GIY-YIG motif/motif A; other site 754093006223 putative active site [active] 754093006224 putative metal binding site [ion binding]; other site 754093006225 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 754093006226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754093006227 Coenzyme A binding pocket [chemical binding]; other site 754093006228 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 754093006229 putative protease; Provisional; Region: PRK15447 754093006230 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 754093006231 hypothetical protein; Provisional; Region: PRK10508 754093006232 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 754093006233 tryptophan permease; Provisional; Region: PRK10483 754093006234 aromatic amino acid transport protein; Region: araaP; TIGR00837 754093006235 lipoprotein NlpI; Provisional; Region: PRK11189 754093006236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754093006237 binding surface 754093006238 TPR motif; other site 754093006239 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 754093006240 16S/18S rRNA binding site [nucleotide binding]; other site 754093006241 S13e-L30e interaction site [polypeptide binding]; other site 754093006242 25S rRNA binding site [nucleotide binding]; other site 754093006243 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 754093006244 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 754093006245 RNA binding site [nucleotide binding]; other site 754093006246 active site 754093006247 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 754093006248 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 754093006249 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 754093006250 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 754093006251 translation initiation factor IF-2; Region: IF-2; TIGR00487 754093006252 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 754093006253 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 754093006254 G1 box; other site 754093006255 putative GEF interaction site [polypeptide binding]; other site 754093006256 GTP/Mg2+ binding site [chemical binding]; other site 754093006257 Switch I region; other site 754093006258 G2 box; other site 754093006259 G3 box; other site 754093006260 Switch II region; other site 754093006261 G4 box; other site 754093006262 G5 box; other site 754093006263 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 754093006264 Translation-initiation factor 2; Region: IF-2; pfam11987 754093006265 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 754093006266 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 754093006267 NusA N-terminal domain; Region: NusA_N; pfam08529 754093006268 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 754093006269 RNA binding site [nucleotide binding]; other site 754093006270 homodimer interface [polypeptide binding]; other site 754093006271 NusA-like KH domain; Region: KH_5; pfam13184 754093006272 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 754093006273 G-X-X-G motif; other site 754093006274 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 754093006275 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 754093006276 ribosome maturation protein RimP; Reviewed; Region: PRK00092 754093006277 Sm and related proteins; Region: Sm_like; cl00259 754093006278 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 754093006279 putative oligomer interface [polypeptide binding]; other site 754093006280 putative RNA binding site [nucleotide binding]; other site 754093006281 argininosuccinate synthase; Validated; Region: PRK05370 754093006282 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 754093006283 Sulfatase; Region: Sulfatase; pfam00884 754093006284 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093006285 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093006286 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 754093006287 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 754093006288 active site 754093006289 substrate binding site [chemical binding]; other site 754093006290 metal binding site [ion binding]; metal-binding site 754093006291 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 754093006292 dihydropteroate synthase; Region: DHPS; TIGR01496 754093006293 substrate binding pocket [chemical binding]; other site 754093006294 dimer interface [polypeptide binding]; other site 754093006295 inhibitor binding site; inhibition site 754093006296 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 754093006297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754093006298 Walker A motif; other site 754093006299 ATP binding site [chemical binding]; other site 754093006300 Walker B motif; other site 754093006301 arginine finger; other site 754093006302 Peptidase family M41; Region: Peptidase_M41; pfam01434 754093006303 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 754093006304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093006305 S-adenosylmethionine binding site [chemical binding]; other site 754093006306 RNA-binding protein YhbY; Provisional; Region: PRK10343 754093006307 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 754093006308 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 754093006309 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 754093006310 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 754093006311 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 754093006312 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 754093006313 GTPase CgtA; Reviewed; Region: obgE; PRK12298 754093006314 GTP1/OBG; Region: GTP1_OBG; pfam01018 754093006315 Obg GTPase; Region: Obg; cd01898 754093006316 G1 box; other site 754093006317 GTP/Mg2+ binding site [chemical binding]; other site 754093006318 Switch I region; other site 754093006319 G2 box; other site 754093006320 G3 box; other site 754093006321 Switch II region; other site 754093006322 G4 box; other site 754093006323 G5 box; other site 754093006324 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754093006325 EamA-like transporter family; Region: EamA; pfam00892 754093006326 EamA-like transporter family; Region: EamA; pfam00892 754093006327 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 754093006328 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 754093006329 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 754093006330 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 754093006331 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 754093006332 substrate binding pocket [chemical binding]; other site 754093006333 chain length determination region; other site 754093006334 substrate-Mg2+ binding site; other site 754093006335 catalytic residues [active] 754093006336 aspartate-rich region 1; other site 754093006337 active site lid residues [active] 754093006338 aspartate-rich region 2; other site 754093006339 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 754093006340 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 754093006341 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 754093006342 hinge; other site 754093006343 active site 754093006344 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 754093006345 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 754093006346 anti sigma factor interaction site; other site 754093006347 regulatory phosphorylation site [posttranslational modification]; other site 754093006348 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 754093006349 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 754093006350 conserved hypothetical integral membrane protein; Region: TIGR00056 754093006351 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 754093006352 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 754093006353 Walker A/P-loop; other site 754093006354 ATP binding site [chemical binding]; other site 754093006355 Q-loop/lid; other site 754093006356 ABC transporter signature motif; other site 754093006357 Walker B; other site 754093006358 D-loop; other site 754093006359 H-loop/switch region; other site 754093006360 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 754093006361 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 754093006362 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 754093006363 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 754093006364 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 754093006365 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 754093006366 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 754093006367 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 754093006368 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 754093006369 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 754093006370 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 754093006371 Walker A/P-loop; other site 754093006372 ATP binding site [chemical binding]; other site 754093006373 Q-loop/lid; other site 754093006374 ABC transporter signature motif; other site 754093006375 Walker B; other site 754093006376 D-loop; other site 754093006377 H-loop/switch region; other site 754093006378 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 754093006379 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 754093006380 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 754093006381 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 754093006382 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 754093006383 30S subunit binding site; other site 754093006384 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 754093006385 active site 754093006386 phosphorylation site [posttranslational modification] 754093006387 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 754093006388 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 754093006389 dimerization domain swap beta strand [polypeptide binding]; other site 754093006390 regulatory protein interface [polypeptide binding]; other site 754093006391 active site 754093006392 regulatory phosphorylation site [posttranslational modification]; other site 754093006393 hypothetical protein; Provisional; Region: PRK10345 754093006394 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 754093006395 Transglycosylase; Region: Transgly; cl17702 754093006396 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 754093006397 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 754093006398 conserved cys residue [active] 754093006399 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 754093006400 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754093006401 putative active site [active] 754093006402 heme pocket [chemical binding]; other site 754093006403 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754093006404 dimer interface [polypeptide binding]; other site 754093006405 phosphorylation site [posttranslational modification] 754093006406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093006407 ATP binding site [chemical binding]; other site 754093006408 Mg2+ binding site [ion binding]; other site 754093006409 G-X-G motif; other site 754093006410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093006411 active site 754093006412 phosphorylation site [posttranslational modification] 754093006413 intermolecular recognition site; other site 754093006414 dimerization interface [polypeptide binding]; other site 754093006415 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 754093006416 putative binding surface; other site 754093006417 active site 754093006418 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 754093006419 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 754093006420 active site 754093006421 dimer interface [polypeptide binding]; other site 754093006422 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 754093006423 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 754093006424 active site 754093006425 FMN binding site [chemical binding]; other site 754093006426 substrate binding site [chemical binding]; other site 754093006427 3Fe-4S cluster binding site [ion binding]; other site 754093006428 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 754093006429 domain interface; other site 754093006430 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 754093006431 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754093006432 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754093006433 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 754093006434 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 754093006435 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 754093006436 N-acetylmannosamine kinase; Provisional; Region: PRK05082 754093006437 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 754093006438 nucleotide binding site [chemical binding]; other site 754093006439 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 754093006440 putative sialic acid transporter; Provisional; Region: PRK03893 754093006441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093006442 putative substrate translocation pore; other site 754093006443 N-acetylneuraminate lyase; Region: nanA; TIGR00683 754093006444 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 754093006445 inhibitor site; inhibition site 754093006446 active site 754093006447 dimer interface [polypeptide binding]; other site 754093006448 catalytic residue [active] 754093006449 transcriptional regulator NanR; Provisional; Region: PRK03837 754093006450 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754093006451 DNA-binding site [nucleotide binding]; DNA binding site 754093006452 FCD domain; Region: FCD; pfam07729 754093006453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093006454 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093006455 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 754093006456 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 754093006457 stringent starvation protein A; Provisional; Region: sspA; PRK09481 754093006458 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 754093006459 C-terminal domain interface [polypeptide binding]; other site 754093006460 putative GSH binding site (G-site) [chemical binding]; other site 754093006461 dimer interface [polypeptide binding]; other site 754093006462 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 754093006463 dimer interface [polypeptide binding]; other site 754093006464 N-terminal domain interface [polypeptide binding]; other site 754093006465 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 754093006466 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 754093006467 23S rRNA interface [nucleotide binding]; other site 754093006468 L3 interface [polypeptide binding]; other site 754093006469 Predicted ATPase [General function prediction only]; Region: COG1485 754093006470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 754093006471 hypothetical protein; Provisional; Region: PRK11677 754093006472 serine endoprotease; Provisional; Region: PRK10898 754093006473 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 754093006474 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754093006475 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 754093006476 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 754093006477 NAD(P) binding site [chemical binding]; other site 754093006478 LDH/MDH dimer interface [polypeptide binding]; other site 754093006479 substrate binding site [chemical binding]; other site 754093006480 arginine repressor; Provisional; Region: PRK05066 754093006481 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 754093006482 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 754093006483 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 754093006484 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 754093006485 RNAase interaction site [polypeptide binding]; other site 754093006486 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 754093006487 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 754093006488 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 754093006489 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754093006490 HlyD family secretion protein; Region: HlyD_3; pfam13437 754093006491 efflux system membrane protein; Provisional; Region: PRK11594 754093006492 transcriptional regulator; Provisional; Region: PRK10632 754093006493 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093006494 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 754093006495 putative effector binding pocket; other site 754093006496 dimerization interface [polypeptide binding]; other site 754093006497 protease TldD; Provisional; Region: tldD; PRK10735 754093006498 hypothetical protein; Provisional; Region: PRK10899 754093006499 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 754093006500 ribonuclease G; Provisional; Region: PRK11712 754093006501 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 754093006502 homodimer interface [polypeptide binding]; other site 754093006503 oligonucleotide binding site [chemical binding]; other site 754093006504 Maf-like protein; Region: Maf; pfam02545 754093006505 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 754093006506 active site 754093006507 dimer interface [polypeptide binding]; other site 754093006508 rod shape-determining protein MreD; Provisional; Region: PRK11060 754093006509 rod shape-determining protein MreC; Region: mreC; TIGR00219 754093006510 rod shape-determining protein MreC; Region: MreC; pfam04085 754093006511 rod shape-determining protein MreB; Provisional; Region: PRK13927 754093006512 MreB and similar proteins; Region: MreB_like; cd10225 754093006513 nucleotide binding site [chemical binding]; other site 754093006514 Mg binding site [ion binding]; other site 754093006515 putative protofilament interaction site [polypeptide binding]; other site 754093006516 RodZ interaction site [polypeptide binding]; other site 754093006517 regulatory protein CsrD; Provisional; Region: PRK11059 754093006518 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 754093006519 metal binding site [ion binding]; metal-binding site 754093006520 active site 754093006521 I-site; other site 754093006522 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754093006523 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 754093006524 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 754093006525 NADP binding site [chemical binding]; other site 754093006526 dimer interface [polypeptide binding]; other site 754093006527 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 754093006528 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 754093006529 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 754093006530 carboxyltransferase (CT) interaction site; other site 754093006531 biotinylation site [posttranslational modification]; other site 754093006532 hypothetical protein; Provisional; Region: PRK10633 754093006533 sodium/panthothenate symporter; Provisional; Region: panF; PRK09442 754093006534 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 754093006535 Na binding site [ion binding]; other site 754093006536 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 754093006537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 754093006538 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 754093006539 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 754093006540 FMN binding site [chemical binding]; other site 754093006541 active site 754093006542 catalytic residues [active] 754093006543 substrate binding site [chemical binding]; other site 754093006544 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 754093006545 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 754093006546 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 754093006547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093006548 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093006549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093006550 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093006551 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093006552 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 754093006553 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 754093006554 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 754093006555 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754093006556 substrate binding pocket [chemical binding]; other site 754093006557 membrane-bound complex binding site; other site 754093006558 hinge residues; other site 754093006559 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 754093006560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093006561 conserved gate region; other site 754093006562 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 754093006563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093006564 dimer interface [polypeptide binding]; other site 754093006565 conserved gate region; other site 754093006566 putative PBP binding loops; other site 754093006567 ABC-ATPase subunit interface; other site 754093006568 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754093006569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093006570 dimer interface [polypeptide binding]; other site 754093006571 conserved gate region; other site 754093006572 putative PBP binding loops; other site 754093006573 ABC-ATPase subunit interface; other site 754093006574 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 754093006575 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 754093006576 Walker A/P-loop; other site 754093006577 ATP binding site [chemical binding]; other site 754093006578 Q-loop/lid; other site 754093006579 ABC transporter signature motif; other site 754093006580 Walker B; other site 754093006581 D-loop; other site 754093006582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093006583 H-loop/switch region; other site 754093006584 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 754093006585 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 754093006586 trimer interface [polypeptide binding]; other site 754093006587 putative metal binding site [ion binding]; other site 754093006588 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 754093006589 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 754093006590 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 754093006591 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 754093006592 shikimate binding site; other site 754093006593 NAD(P) binding site [chemical binding]; other site 754093006594 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 754093006595 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 754093006596 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 754093006597 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 754093006598 hypothetical protein; Validated; Region: PRK03430 754093006599 hypothetical protein; Provisional; Region: PRK10736 754093006600 DNA protecting protein DprA; Region: dprA; TIGR00732 754093006601 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 754093006602 active site 754093006603 catalytic residues [active] 754093006604 metal binding site [ion binding]; metal-binding site 754093006605 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 754093006606 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 754093006607 putative active site [active] 754093006608 substrate binding site [chemical binding]; other site 754093006609 putative cosubstrate binding site; other site 754093006610 catalytic site [active] 754093006611 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 754093006612 substrate binding site [chemical binding]; other site 754093006613 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 754093006614 TrkA-N domain; Region: TrkA_N; pfam02254 754093006615 TrkA-C domain; Region: TrkA_C; pfam02080 754093006616 TrkA-N domain; Region: TrkA_N; pfam02254 754093006617 TrkA-C domain; Region: TrkA_C; pfam02080 754093006618 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 754093006619 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 754093006620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 754093006621 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 754093006622 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 754093006623 DNA binding residues [nucleotide binding] 754093006624 dimer interface [polypeptide binding]; other site 754093006625 metal binding site [ion binding]; metal-binding site 754093006626 hypothetical protein; Provisional; Region: PRK10203 754093006627 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 754093006628 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 754093006629 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 754093006630 alphaNTD homodimer interface [polypeptide binding]; other site 754093006631 alphaNTD - beta interaction site [polypeptide binding]; other site 754093006632 alphaNTD - beta' interaction site [polypeptide binding]; other site 754093006633 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 754093006634 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 754093006635 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 754093006636 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754093006637 RNA binding surface [nucleotide binding]; other site 754093006638 30S ribosomal protein S11; Validated; Region: PRK05309 754093006639 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 754093006640 30S ribosomal protein S13; Region: bact_S13; TIGR03631 754093006641 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 754093006642 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 754093006643 SecY translocase; Region: SecY; pfam00344 754093006644 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 754093006645 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 754093006646 23S rRNA binding site [nucleotide binding]; other site 754093006647 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 754093006648 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 754093006649 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 754093006650 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 754093006651 23S rRNA interface [nucleotide binding]; other site 754093006652 5S rRNA interface [nucleotide binding]; other site 754093006653 L27 interface [polypeptide binding]; other site 754093006654 L5 interface [polypeptide binding]; other site 754093006655 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 754093006656 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 754093006657 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 754093006658 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 754093006659 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 754093006660 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 754093006661 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 754093006662 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 754093006663 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 754093006664 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 754093006665 RNA binding site [nucleotide binding]; other site 754093006666 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 754093006667 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 754093006668 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 754093006669 23S rRNA interface [nucleotide binding]; other site 754093006670 putative translocon interaction site; other site 754093006671 signal recognition particle (SRP54) interaction site; other site 754093006672 L23 interface [polypeptide binding]; other site 754093006673 trigger factor interaction site; other site 754093006674 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 754093006675 23S rRNA interface [nucleotide binding]; other site 754093006676 5S rRNA interface [nucleotide binding]; other site 754093006677 putative antibiotic binding site [chemical binding]; other site 754093006678 L25 interface [polypeptide binding]; other site 754093006679 L27 interface [polypeptide binding]; other site 754093006680 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 754093006681 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 754093006682 G-X-X-G motif; other site 754093006683 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 754093006684 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 754093006685 protein-rRNA interface [nucleotide binding]; other site 754093006686 putative translocon binding site; other site 754093006687 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 754093006688 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 754093006689 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 754093006690 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 754093006691 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 754093006692 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 754093006693 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 754093006694 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 754093006695 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 754093006696 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 754093006697 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 754093006698 heme binding site [chemical binding]; other site 754093006699 ferroxidase pore; other site 754093006700 ferroxidase diiron center [ion binding]; other site 754093006701 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 754093006702 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 754093006703 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 754093006704 Antibiotic Binding Site [chemical binding]; other site 754093006705 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 754093006706 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 754093006707 G1 box; other site 754093006708 GEF interaction site [polypeptide binding]; other site 754093006709 GTP/Mg2+ binding site [chemical binding]; other site 754093006710 Switch I region; other site 754093006711 G2 box; other site 754093006712 G3 box; other site 754093006713 Switch II region; other site 754093006714 G4 box; other site 754093006715 G5 box; other site 754093006716 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 754093006717 elongation factor G; Reviewed; Region: PRK00007 754093006718 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 754093006719 G1 box; other site 754093006720 putative GEF interaction site [polypeptide binding]; other site 754093006721 GTP/Mg2+ binding site [chemical binding]; other site 754093006722 Switch I region; other site 754093006723 G2 box; other site 754093006724 G3 box; other site 754093006725 Switch II region; other site 754093006726 G4 box; other site 754093006727 G5 box; other site 754093006728 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 754093006729 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 754093006730 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 754093006731 30S ribosomal protein S7; Validated; Region: PRK05302 754093006732 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 754093006733 S17 interaction site [polypeptide binding]; other site 754093006734 S8 interaction site; other site 754093006735 16S rRNA interaction site [nucleotide binding]; other site 754093006736 streptomycin interaction site [chemical binding]; other site 754093006737 23S rRNA interaction site [nucleotide binding]; other site 754093006738 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 754093006739 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 754093006740 sulfur relay protein TusC; Validated; Region: PRK00211 754093006741 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 754093006742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 754093006743 YheO-like PAS domain; Region: PAS_6; pfam08348 754093006744 HTH domain; Region: HTH_22; pfam13309 754093006745 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 754093006746 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 754093006747 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 754093006748 phi X174 lysis protein; Provisional; Region: PRK02793 754093006749 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 754093006750 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 754093006751 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 754093006752 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 754093006753 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 754093006754 TrkA-N domain; Region: TrkA_N; pfam02254 754093006755 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 754093006756 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 754093006757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093006758 Walker A/P-loop; other site 754093006759 ATP binding site [chemical binding]; other site 754093006760 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754093006761 ABC transporter signature motif; other site 754093006762 Walker B; other site 754093006763 D-loop; other site 754093006764 ABC transporter; Region: ABC_tran_2; pfam12848 754093006765 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754093006766 putative hydrolase; Provisional; Region: PRK10985 754093006767 hypothetical protein; Provisional; Region: PRK04966 754093006768 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 754093006769 active site 754093006770 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 754093006771 hypothetical protein; Provisional; Region: PRK10738 754093006772 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 754093006773 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 754093006774 ligand binding site [chemical binding]; other site 754093006775 flexible hinge region; other site 754093006776 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 754093006777 putative switch regulator; other site 754093006778 non-specific DNA interactions [nucleotide binding]; other site 754093006779 DNA binding site [nucleotide binding] 754093006780 sequence specific DNA binding site [nucleotide binding]; other site 754093006781 putative cAMP binding site [chemical binding]; other site 754093006782 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 754093006783 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754093006784 inhibitor-cofactor binding pocket; inhibition site 754093006785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093006786 catalytic residue [active] 754093006787 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 754093006788 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 754093006789 glutamine binding [chemical binding]; other site 754093006790 catalytic triad [active] 754093006791 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 754093006792 cell filamentation protein Fic; Provisional; Region: PRK10347 754093006793 hypothetical protein; Provisional; Region: PRK10204 754093006794 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 754093006795 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 754093006796 substrate binding site [chemical binding]; other site 754093006797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093006798 putative substrate translocation pore; other site 754093006799 putative transporter; Provisional; Region: PRK03699 754093006800 nitrite reductase subunit NirD; Provisional; Region: PRK14989 754093006801 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754093006802 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 754093006803 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 754093006804 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 754093006805 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 754093006806 nitrite transporter NirC; Provisional; Region: PRK11562 754093006807 siroheme synthase; Provisional; Region: cysG; PRK10637 754093006808 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 754093006809 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 754093006810 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 754093006811 active site 754093006812 SAM binding site [chemical binding]; other site 754093006813 homodimer interface [polypeptide binding]; other site 754093006814 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093006815 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093006816 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093006817 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 754093006818 catalytic residue [active] 754093006819 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 754093006820 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093006821 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093006822 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 754093006823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093006824 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 754093006825 Protein export membrane protein; Region: SecD_SecF; cl14618 754093006826 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 754093006827 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754093006828 HlyD family secretion protein; Region: HlyD_3; pfam13437 754093006829 pyruvate kinase; Provisional; Region: PRK05826 754093006830 acid-resistance membrane protein; Provisional; Region: PRK10209 754093006831 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 754093006832 acid-resistance protein; Provisional; Region: PRK10208 754093006833 acid-resistance protein; Provisional; Region: hdeB; PRK11566 754093006834 MgtC family; Region: MgtC; pfam02308 754093006835 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093006836 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093006837 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 754093006838 MgtC family; Region: MgtC; pfam02308 754093006839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754093006840 NADH(P)-binding; Region: NAD_binding_10; pfam13460 754093006841 active site 754093006842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754093006843 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 754093006844 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 754093006845 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 754093006846 putative hemin binding site; other site 754093006847 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 754093006848 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 754093006849 N-terminal plug; other site 754093006850 ligand-binding site [chemical binding]; other site 754093006851 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 754093006852 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 754093006853 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 754093006854 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754093006855 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754093006856 DNA binding residues [nucleotide binding] 754093006857 dimerization interface [polypeptide binding]; other site 754093006858 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 754093006859 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093006860 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093006861 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 754093006862 ArsC family; Region: ArsC; pfam03960 754093006863 catalytic residues [active] 754093006864 arsenical pump membrane protein; Provisional; Region: PRK15445 754093006865 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 754093006866 transmembrane helices; other site 754093006867 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754093006868 dimerization interface [polypeptide binding]; other site 754093006869 putative DNA binding site [nucleotide binding]; other site 754093006870 putative Zn2+ binding site [ion binding]; other site 754093006871 glutathione reductase; Validated; Region: PRK06116 754093006872 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754093006873 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754093006874 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 754093006875 oligopeptidase A; Provisional; Region: PRK10911 754093006876 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 754093006877 active site 754093006878 Zn binding site [ion binding]; other site 754093006879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093006880 S-adenosylmethionine binding site [chemical binding]; other site 754093006881 POT family; Region: PTR2; cl17359 754093006882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093006883 POT family; Region: PTR2; pfam00854 754093006884 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 754093006885 Ligand Binding Site [chemical binding]; other site 754093006886 universal stress protein UspB; Provisional; Region: PRK04960 754093006887 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 754093006888 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 754093006889 Predicted flavoproteins [General function prediction only]; Region: COG2081 754093006890 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754093006891 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093006892 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093006893 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093006894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093006895 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093006896 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093006897 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093006898 glycogen phosphorylase; Provisional; Region: PRK14986 754093006899 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 754093006900 homodimer interface [polypeptide binding]; other site 754093006901 active site pocket [active] 754093006902 glycogen synthase; Provisional; Region: glgA; PRK00654 754093006903 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 754093006904 ADP-binding pocket [chemical binding]; other site 754093006905 homodimer interface [polypeptide binding]; other site 754093006906 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 754093006907 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 754093006908 ligand binding site; other site 754093006909 oligomer interface; other site 754093006910 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 754093006911 sulfate 1 binding site; other site 754093006912 glycogen debranching enzyme; Provisional; Region: PRK03705 754093006913 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 754093006914 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 754093006915 active site 754093006916 catalytic site [active] 754093006917 glycogen branching enzyme; Provisional; Region: PRK05402 754093006918 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 754093006919 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 754093006920 active site 754093006921 catalytic site [active] 754093006922 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 754093006923 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 754093006924 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 754093006925 putative antibiotic transporter; Provisional; Region: PRK10739 754093006926 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 754093006927 DNA protecting protein DprA; Region: dprA; TIGR00732 754093006928 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 754093006929 DNA binding site [nucleotide binding] 754093006930 sequence specific DNA binding site [nucleotide binding]; other site 754093006931 putative cAMP binding site [chemical binding]; other site 754093006932 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754093006933 active site 754093006934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093006935 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093006936 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093006937 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093006938 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093006939 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093006940 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093006941 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093006942 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 754093006943 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754093006944 ATP binding site [chemical binding]; other site 754093006945 putative Mg++ binding site [ion binding]; other site 754093006946 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754093006947 nucleotide binding region [chemical binding]; other site 754093006948 ATP-binding site [chemical binding]; other site 754093006949 low affinity gluconate transporter; Provisional; Region: PRK10472 754093006950 gluconate transporter; Region: gntP; TIGR00791 754093006951 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 754093006952 ATP-binding site [chemical binding]; other site 754093006953 Gluconate-6-phosphate binding site [chemical binding]; other site 754093006954 Shikimate kinase; Region: SKI; pfam01202 754093006955 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 754093006956 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754093006957 DNA binding site [nucleotide binding] 754093006958 domain linker motif; other site 754093006959 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 754093006960 putative ligand binding site [chemical binding]; other site 754093006961 putative dimerization interface [polypeptide binding]; other site 754093006962 Pirin-related protein [General function prediction only]; Region: COG1741 754093006963 Pirin; Region: Pirin; pfam02678 754093006964 putative oxidoreductase; Provisional; Region: PRK10206 754093006965 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754093006966 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 754093006967 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093006968 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093006969 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 754093006970 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 754093006971 hypothetical protein; Provisional; Region: PRK10350 754093006972 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 754093006973 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 754093006974 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 754093006975 putative active site [active] 754093006976 catalytic site [active] 754093006977 putative metal binding site [ion binding]; other site 754093006978 TOBE domain; Region: TOBE_2; pfam08402 754093006979 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093006980 Walker B; other site 754093006981 D-loop; other site 754093006982 H-loop/switch region; other site 754093006983 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754093006984 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 754093006985 Walker A/P-loop; other site 754093006986 ATP binding site [chemical binding]; other site 754093006987 Q-loop/lid; other site 754093006988 ABC transporter signature motif; other site 754093006989 Walker B; other site 754093006990 D-loop; other site 754093006991 H-loop/switch region; other site 754093006992 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754093006993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093006994 putative PBP binding loops; other site 754093006995 ABC-ATPase subunit interface; other site 754093006996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 754093006997 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754093006998 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 754093006999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093007000 dimer interface [polypeptide binding]; other site 754093007001 conserved gate region; other site 754093007002 putative PBP binding loops; other site 754093007003 ABC-ATPase subunit interface; other site 754093007004 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754093007005 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754093007006 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 754093007007 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 754093007008 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 754093007009 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 754093007010 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 754093007011 Walker A/P-loop; other site 754093007012 ATP binding site [chemical binding]; other site 754093007013 Q-loop/lid; other site 754093007014 ABC transporter signature motif; other site 754093007015 Walker B; other site 754093007016 D-loop; other site 754093007017 H-loop/switch region; other site 754093007018 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 754093007019 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 754093007020 Walker A/P-loop; other site 754093007021 ATP binding site [chemical binding]; other site 754093007022 Q-loop/lid; other site 754093007023 ABC transporter signature motif; other site 754093007024 Walker B; other site 754093007025 D-loop; other site 754093007026 H-loop/switch region; other site 754093007027 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 754093007028 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 754093007029 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 754093007030 TM-ABC transporter signature motif; other site 754093007031 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754093007032 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 754093007033 TM-ABC transporter signature motif; other site 754093007034 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007035 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 754093007036 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 754093007037 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 754093007038 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 754093007039 dimerization interface [polypeptide binding]; other site 754093007040 ligand binding site [chemical binding]; other site 754093007041 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 754093007042 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754093007043 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754093007044 DNA binding residues [nucleotide binding] 754093007045 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 754093007046 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 754093007047 cell division protein FtsE; Provisional; Region: PRK10908 754093007048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093007049 Walker A/P-loop; other site 754093007050 ATP binding site [chemical binding]; other site 754093007051 Q-loop/lid; other site 754093007052 ABC transporter signature motif; other site 754093007053 Walker B; other site 754093007054 D-loop; other site 754093007055 H-loop/switch region; other site 754093007056 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 754093007057 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 754093007058 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 754093007059 P loop; other site 754093007060 GTP binding site [chemical binding]; other site 754093007061 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 754093007062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093007063 S-adenosylmethionine binding site [chemical binding]; other site 754093007064 hypothetical protein; Provisional; Region: PRK10910 754093007065 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 754093007066 Predicted membrane protein [Function unknown]; Region: COG3714 754093007067 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 754093007068 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 754093007069 metal-binding site [ion binding] 754093007070 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 754093007071 Soluble P-type ATPase [General function prediction only]; Region: COG4087 754093007072 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 754093007073 CPxP motif; other site 754093007074 hypothetical protein; Provisional; Region: PRK11212 754093007075 hypothetical protein; Provisional; Region: PRK11615 754093007076 major facilitator superfamily transporter; Provisional; Region: PRK05122 754093007077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093007078 putative substrate translocation pore; other site 754093007079 major facilitator superfamily transporter; Provisional; Region: PRK05122 754093007080 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 754093007081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093007082 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093007083 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093007084 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007085 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007086 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093007088 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093007089 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093007090 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 754093007091 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 754093007092 dimer interface [polypeptide binding]; other site 754093007093 active site 754093007094 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 754093007095 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 754093007096 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754093007097 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 754093007098 substrate binding site [chemical binding]; other site 754093007099 nickel transporter permease NikB; Provisional; Region: PRK10352 754093007100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093007101 dimer interface [polypeptide binding]; other site 754093007102 conserved gate region; other site 754093007103 putative PBP binding loops; other site 754093007104 ABC-ATPase subunit interface; other site 754093007105 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 754093007106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093007107 dimer interface [polypeptide binding]; other site 754093007108 conserved gate region; other site 754093007109 putative PBP binding loops; other site 754093007110 ABC-ATPase subunit interface; other site 754093007111 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 754093007112 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754093007113 Walker A/P-loop; other site 754093007114 ATP binding site [chemical binding]; other site 754093007115 Q-loop/lid; other site 754093007116 ABC transporter signature motif; other site 754093007117 Walker B; other site 754093007118 D-loop; other site 754093007119 H-loop/switch region; other site 754093007120 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754093007121 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 754093007122 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754093007123 Walker A/P-loop; other site 754093007124 ATP binding site [chemical binding]; other site 754093007125 Q-loop/lid; other site 754093007126 ABC transporter signature motif; other site 754093007127 Walker B; other site 754093007128 D-loop; other site 754093007129 H-loop/switch region; other site 754093007130 nickel responsive regulator; Provisional; Region: PRK02967 754093007131 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 754093007132 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007133 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007134 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007135 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 754093007136 active site 754093007137 phosphorylation site [posttranslational modification] 754093007138 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 754093007139 active site 754093007140 P-loop; other site 754093007141 phosphorylation site [posttranslational modification] 754093007142 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 754093007143 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007144 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093007145 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093007146 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093007147 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 754093007148 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 754093007149 active site residue [active] 754093007150 intramembrane serine protease GlpG; Provisional; Region: PRK10907 754093007151 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 754093007152 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 754093007153 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 754093007154 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 754093007155 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754093007156 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 754093007157 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 754093007158 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 754093007159 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 754093007160 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 754093007161 putative active site [active] 754093007162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 754093007163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 754093007164 maltodextrin phosphorylase; Provisional; Region: PRK14985 754093007165 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 754093007166 homodimer interface [polypeptide binding]; other site 754093007167 active site pocket [active] 754093007168 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 754093007169 4-alpha-glucanotransferase; Region: malQ; TIGR00217 754093007170 high-affinity gluconate transporter; Provisional; Region: PRK14984 754093007171 gluconate transporter; Region: gntP; TIGR00791 754093007172 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 754093007173 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 754093007174 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 754093007175 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754093007176 active site 754093007177 carboxylesterase BioH; Provisional; Region: PRK10349 754093007178 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 754093007179 putative transposase; Provisional; Region: PRK09857 754093007180 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 754093007181 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 754093007182 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 754093007183 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 754093007184 G1 box; other site 754093007185 GTP/Mg2+ binding site [chemical binding]; other site 754093007186 Switch I region; other site 754093007187 G2 box; other site 754093007188 G3 box; other site 754093007189 Switch II region; other site 754093007190 G4 box; other site 754093007191 G5 box; other site 754093007192 Nucleoside recognition; Region: Gate; pfam07670 754093007193 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 754093007194 Nucleoside recognition; Region: Gate; pfam07670 754093007195 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 754093007196 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 754093007197 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 754093007198 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 754093007199 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 754093007200 RNA binding site [nucleotide binding]; other site 754093007201 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 754093007202 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 754093007203 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 754093007204 osmolarity response regulator; Provisional; Region: ompR; PRK09468 754093007205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093007206 active site 754093007207 phosphorylation site [posttranslational modification] 754093007208 intermolecular recognition site; other site 754093007209 dimerization interface [polypeptide binding]; other site 754093007210 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754093007211 DNA binding site [nucleotide binding] 754093007212 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 754093007213 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754093007214 dimerization interface [polypeptide binding]; other site 754093007215 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754093007216 dimer interface [polypeptide binding]; other site 754093007217 phosphorylation site [posttranslational modification] 754093007218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093007219 ATP binding site [chemical binding]; other site 754093007220 G-X-G motif; other site 754093007221 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 754093007222 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 754093007223 active site 754093007224 substrate-binding site [chemical binding]; other site 754093007225 metal-binding site [ion binding] 754093007226 ATP binding site [chemical binding]; other site 754093007227 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 754093007228 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007229 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093007230 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093007231 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093007232 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 754093007233 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 754093007234 dimerization interface [polypeptide binding]; other site 754093007235 domain crossover interface; other site 754093007236 redox-dependent activation switch; other site 754093007237 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754093007238 RNA binding surface [nucleotide binding]; other site 754093007239 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 754093007240 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093007241 motif II; other site 754093007242 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 754093007243 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 754093007244 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 754093007245 ADP-ribose binding site [chemical binding]; other site 754093007246 dimer interface [polypeptide binding]; other site 754093007247 active site 754093007248 nudix motif; other site 754093007249 metal binding site [ion binding]; metal-binding site 754093007250 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 754093007251 Transglycosylase; Region: Transgly; pfam00912 754093007252 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 754093007253 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 754093007254 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 754093007255 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 754093007256 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 754093007257 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 754093007258 shikimate kinase; Reviewed; Region: aroK; PRK00131 754093007259 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 754093007260 ADP binding site [chemical binding]; other site 754093007261 magnesium binding site [ion binding]; other site 754093007262 putative shikimate binding site; other site 754093007263 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 754093007264 active site 754093007265 dimer interface [polypeptide binding]; other site 754093007266 metal binding site [ion binding]; metal-binding site 754093007267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 754093007268 cell division protein DamX; Validated; Region: PRK10905 754093007269 DNA adenine methylase; Provisional; Region: PRK10904 754093007270 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 754093007271 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 754093007272 substrate binding site [chemical binding]; other site 754093007273 hexamer interface [polypeptide binding]; other site 754093007274 metal binding site [ion binding]; metal-binding site 754093007275 phosphoglycolate phosphatase; Provisional; Region: PRK13222 754093007276 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 754093007277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093007278 motif II; other site 754093007279 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 754093007280 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 754093007281 active site 754093007282 HIGH motif; other site 754093007283 dimer interface [polypeptide binding]; other site 754093007284 KMSKS motif; other site 754093007285 Transposase; Region: HTH_Tnp_1; cl17663 754093007286 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093007287 Integrase core domain; Region: rve; pfam00665 754093007288 Integrase core domain; Region: rve_3; pfam13683 754093007289 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 754093007290 catalytic residue [active] 754093007291 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 754093007292 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754093007293 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 754093007294 putative mutase; Provisional; Region: PRK12383 754093007295 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 754093007296 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 754093007297 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 754093007298 active site 754093007299 substrate binding pocket [chemical binding]; other site 754093007300 homodimer interaction site [polypeptide binding]; other site 754093007301 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 754093007302 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007303 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 754093007304 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093007305 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 754093007306 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754093007307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093007308 homodimer interface [polypeptide binding]; other site 754093007309 catalytic residue [active] 754093007310 alpha-amylase; Reviewed; Region: malS; PRK09505 754093007311 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 754093007312 Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551 754093007313 active site 754093007314 catalytic site [active] 754093007315 alpha-amylase; Reviewed; Region: malS; PRK09505 754093007316 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 754093007317 hypothetical protein; Provisional; Region: PRK10356 754093007318 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 754093007319 Transcriptional regulators [Transcription]; Region: PurR; COG1609 754093007320 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 754093007321 putative ligand binding site [chemical binding]; other site 754093007322 putative dimerization interface [polypeptide binding]; other site 754093007323 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093007324 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 754093007325 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093007326 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007327 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093007328 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093007329 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093007330 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 754093007331 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 754093007332 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 754093007333 purine monophosphate binding site [chemical binding]; other site 754093007334 dimer interface [polypeptide binding]; other site 754093007335 putative catalytic residues [active] 754093007336 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 754093007337 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 754093007338 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 754093007339 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 754093007340 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 754093007341 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 754093007342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093007343 active site 754093007344 phosphorylation site [posttranslational modification] 754093007345 intermolecular recognition site; other site 754093007346 dimerization interface [polypeptide binding]; other site 754093007347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754093007348 Walker A motif; other site 754093007349 ATP binding site [chemical binding]; other site 754093007350 Walker B motif; other site 754093007351 arginine finger; other site 754093007352 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 754093007353 sensor protein ZraS; Provisional; Region: PRK10364 754093007354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754093007355 dimer interface [polypeptide binding]; other site 754093007356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093007357 ATP binding site [chemical binding]; other site 754093007358 Mg2+ binding site [ion binding]; other site 754093007359 G-X-G motif; other site 754093007360 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 754093007361 dimer interface [polypeptide binding]; other site 754093007362 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 754093007363 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 754093007364 IHF - DNA interface [nucleotide binding]; other site 754093007365 IHF dimer interface [polypeptide binding]; other site 754093007366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 754093007367 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 754093007368 Active_site [active] 754093007369 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 754093007370 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 754093007371 substrate binding site [chemical binding]; other site 754093007372 active site 754093007373 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 754093007374 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 754093007375 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 754093007376 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 754093007377 putative NADH binding site [chemical binding]; other site 754093007378 putative active site [active] 754093007379 nudix motif; other site 754093007380 putative metal binding site [ion binding]; other site 754093007381 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 754093007382 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 754093007383 ThiC-associated domain; Region: ThiC-associated; pfam13667 754093007384 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 754093007385 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 754093007386 thiamine phosphate binding site [chemical binding]; other site 754093007387 active site 754093007388 pyrophosphate binding site [ion binding]; other site 754093007389 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 754093007390 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 754093007391 phosphate binding site [ion binding]; other site 754093007392 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 754093007393 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754093007394 FeS/SAM binding site; other site 754093007395 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 754093007396 stationary phase growth adaptation protein; Provisional; Region: PRK09717 754093007397 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 754093007398 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 754093007399 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 754093007400 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 754093007401 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 754093007402 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 754093007403 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 754093007404 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 754093007405 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 754093007406 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 754093007407 DNA binding site [nucleotide binding] 754093007408 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 754093007409 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 754093007410 core dimer interface [polypeptide binding]; other site 754093007411 peripheral dimer interface [polypeptide binding]; other site 754093007412 L10 interface [polypeptide binding]; other site 754093007413 L11 interface [polypeptide binding]; other site 754093007414 putative EF-Tu interaction site [polypeptide binding]; other site 754093007415 putative EF-G interaction site [polypeptide binding]; other site 754093007416 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 754093007417 23S rRNA interface [nucleotide binding]; other site 754093007418 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 754093007419 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 754093007420 mRNA/rRNA interface [nucleotide binding]; other site 754093007421 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 754093007422 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 754093007423 23S rRNA interface [nucleotide binding]; other site 754093007424 L7/L12 interface [polypeptide binding]; other site 754093007425 putative thiostrepton binding site; other site 754093007426 L25 interface [polypeptide binding]; other site 754093007427 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 754093007428 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 754093007429 putative homodimer interface [polypeptide binding]; other site 754093007430 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 754093007431 heterodimer interface [polypeptide binding]; other site 754093007432 homodimer interface [polypeptide binding]; other site 754093007433 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 754093007434 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 754093007435 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 754093007436 Antibiotic Binding Site [chemical binding]; other site 754093007437 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 754093007438 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 754093007439 G1 box; other site 754093007440 GEF interaction site [polypeptide binding]; other site 754093007441 GTP/Mg2+ binding site [chemical binding]; other site 754093007442 Switch I region; other site 754093007443 G2 box; other site 754093007444 G3 box; other site 754093007445 Switch II region; other site 754093007446 G4 box; other site 754093007447 G5 box; other site 754093007448 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 754093007449 pantothenate kinase; Provisional; Region: PRK05439 754093007450 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 754093007451 ATP-binding site [chemical binding]; other site 754093007452 CoA-binding site [chemical binding]; other site 754093007453 Mg2+-binding site [ion binding]; other site 754093007454 Biotin operon repressor [Transcription]; Region: BirA; COG1654 754093007455 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 754093007456 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 754093007457 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 754093007458 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 754093007459 FAD binding domain; Region: FAD_binding_4; pfam01565 754093007460 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 754093007461 glutamate racemase; Provisional; Region: PRK00865 754093007462 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 754093007463 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 754093007464 N-terminal plug; other site 754093007465 ligand-binding site [chemical binding]; other site 754093007466 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 754093007467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093007468 S-adenosylmethionine binding site [chemical binding]; other site 754093007469 hypothetical protein; Provisional; Region: PRK11056 754093007470 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 754093007471 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754093007472 metabolite-proton symporter; Region: 2A0106; TIGR00883 754093007473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093007474 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093007475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093007476 putative substrate translocation pore; other site 754093007477 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 754093007478 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 754093007479 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 754093007480 metal binding site [ion binding]; metal-binding site 754093007481 putative dimer interface [polypeptide binding]; other site 754093007482 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007483 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093007484 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093007485 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093007486 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007487 hypothetical protein; Provisional; Region: PRK10030 754093007488 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 754093007489 dimerization interface [polypeptide binding]; other site 754093007490 DNA binding site [nucleotide binding] 754093007491 corepressor binding sites; other site 754093007492 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 754093007493 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 754093007494 putative catalytic residues [active] 754093007495 putative nucleotide binding site [chemical binding]; other site 754093007496 putative aspartate binding site [chemical binding]; other site 754093007497 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 754093007498 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 754093007499 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 754093007500 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 754093007501 FAD binding site [chemical binding]; other site 754093007502 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 754093007503 heme binding site [chemical binding]; other site 754093007504 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 754093007505 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 754093007506 heme binding site [chemical binding]; other site 754093007507 EamA-like transporter family; Region: EamA; pfam00892 754093007508 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 754093007509 EamA-like transporter family; Region: EamA; pfam00892 754093007510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 754093007511 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 754093007512 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 754093007513 dimer interface [polypeptide binding]; other site 754093007514 active site 754093007515 metal binding site [ion binding]; metal-binding site 754093007516 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 754093007517 active site 754093007518 intersubunit interactions; other site 754093007519 catalytic residue [active] 754093007520 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 754093007521 dimerization domain swap beta strand [polypeptide binding]; other site 754093007522 regulatory protein interface [polypeptide binding]; other site 754093007523 active site 754093007524 regulatory phosphorylation site [posttranslational modification]; other site 754093007525 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 754093007526 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 754093007527 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 754093007528 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 754093007529 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 754093007530 active site 754093007531 phosphorylation site [posttranslational modification] 754093007532 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 754093007533 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 754093007534 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 754093007535 active site 754093007536 P-loop; other site 754093007537 phosphorylation site [posttranslational modification] 754093007538 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 754093007539 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 754093007540 dimer interface [polypeptide binding]; other site 754093007541 active site 754093007542 glycine loop; other site 754093007543 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754093007544 FeS/SAM binding site; other site 754093007545 pyruvate formate lyase II activase; Provisional; Region: PRK10076 754093007546 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 754093007547 active site 754093007548 P-loop; other site 754093007549 phosphorylation site [posttranslational modification] 754093007550 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 754093007551 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093007552 hypothetical protein; Provisional; Region: PRK10649 754093007553 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 754093007554 Sulfatase; Region: Sulfatase; pfam00884 754093007555 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 754093007556 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 754093007557 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 754093007558 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 754093007559 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 754093007560 nucleotide binding site [chemical binding]; other site 754093007561 N-acetyl-L-glutamate binding site [chemical binding]; other site 754093007562 argininosuccinate lyase; Provisional; Region: PRK04833 754093007563 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 754093007564 active sites [active] 754093007565 tetramer interface [polypeptide binding]; other site 754093007566 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 754093007567 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093007568 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 754093007569 dimerization interface [polypeptide binding]; other site 754093007570 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 754093007571 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754093007572 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 754093007573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093007574 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093007575 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093007576 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093007577 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093007578 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093007579 RHS Repeat; Region: RHS_repeat; pfam05593 754093007580 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 754093007581 RHS Repeat; Region: RHS_repeat; cl11982 754093007582 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 754093007583 RHS Repeat; Region: RHS_repeat; pfam05593 754093007584 RHS protein; Region: RHS; pfam03527 754093007585 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 754093007586 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 754093007587 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754093007588 DNA binding site [nucleotide binding] 754093007589 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 754093007590 domain linker motif; other site 754093007591 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 754093007592 dimerization interface [polypeptide binding]; other site 754093007593 ligand binding site [chemical binding]; other site 754093007594 essential cell division protein FtsN; Provisional; Region: PRK10927 754093007595 cell division protein FtsN; Provisional; Region: PRK12757 754093007596 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 754093007597 active site 754093007598 HslU subunit interaction site [polypeptide binding]; other site 754093007599 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 754093007600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754093007601 Walker A motif; other site 754093007602 ATP binding site [chemical binding]; other site 754093007603 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 754093007604 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 754093007605 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 754093007606 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007607 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007608 HTH-like domain; Region: HTH_21; pfam13276 754093007609 Integrase core domain; Region: rve; pfam00665 754093007610 Integrase core domain; Region: rve_2; pfam13333 754093007611 septal ring assembly protein ZapB; Provisional; Region: PRK15422 754093007612 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 754093007613 amphipathic channel; other site 754093007614 Asn-Pro-Ala signature motifs; other site 754093007615 glycerol kinase; Provisional; Region: glpK; PRK00047 754093007616 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 754093007617 N- and C-terminal domain interface [polypeptide binding]; other site 754093007618 active site 754093007619 MgATP binding site [chemical binding]; other site 754093007620 catalytic site [active] 754093007621 metal binding site [ion binding]; metal-binding site 754093007622 glycerol binding site [chemical binding]; other site 754093007623 homotetramer interface [polypeptide binding]; other site 754093007624 homodimer interface [polypeptide binding]; other site 754093007625 FBP binding site [chemical binding]; other site 754093007626 protein IIAGlc interface [polypeptide binding]; other site 754093007627 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 754093007628 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 754093007629 putative active site [active] 754093007630 ferredoxin-NADP reductase; Provisional; Region: PRK10926 754093007631 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 754093007632 FAD binding pocket [chemical binding]; other site 754093007633 FAD binding motif [chemical binding]; other site 754093007634 phosphate binding motif [ion binding]; other site 754093007635 beta-alpha-beta structure motif; other site 754093007636 NAD binding pocket [chemical binding]; other site 754093007637 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 754093007638 Ligand Binding Site [chemical binding]; other site 754093007639 hypothetical protein; Provisional; Region: PRK09981 754093007640 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007641 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093007642 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093007643 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093007644 Predicted membrane protein [Function unknown]; Region: COG3152 754093007645 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 754093007646 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 754093007647 triosephosphate isomerase; Provisional; Region: PRK14567 754093007648 substrate binding site [chemical binding]; other site 754093007649 dimer interface [polypeptide binding]; other site 754093007650 catalytic triad [active] 754093007651 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 754093007652 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007653 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007654 sulfate transporter subunit; Provisional; Region: PRK10752 754093007655 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 754093007656 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 754093007657 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 754093007658 active site 754093007659 ADP/pyrophosphate binding site [chemical binding]; other site 754093007660 dimerization interface [polypeptide binding]; other site 754093007661 allosteric effector site; other site 754093007662 fructose-1,6-bisphosphate binding site; other site 754093007663 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 754093007664 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 754093007665 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 754093007666 dimer interface [polypeptide binding]; other site 754093007667 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 754093007668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093007669 active site 754093007670 intermolecular recognition site; other site 754093007671 dimerization interface [polypeptide binding]; other site 754093007672 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754093007673 DNA binding site [nucleotide binding] 754093007674 two-component sensor protein; Provisional; Region: cpxA; PRK09470 754093007675 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754093007676 dimerization interface [polypeptide binding]; other site 754093007677 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754093007678 dimer interface [polypeptide binding]; other site 754093007679 phosphorylation site [posttranslational modification] 754093007680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093007681 ATP binding site [chemical binding]; other site 754093007682 Mg2+ binding site [ion binding]; other site 754093007683 G-X-G motif; other site 754093007684 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 754093007685 MOSC domain; Region: MOSC; pfam03473 754093007686 3-alpha domain; Region: 3-alpha; pfam03475 754093007687 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 754093007688 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 754093007689 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 754093007690 transcriptional activator RhaS; Provisional; Region: PRK13503 754093007691 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 754093007692 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093007693 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093007694 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 754093007695 nucleotide binding site [chemical binding]; other site 754093007696 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 754093007697 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 754093007698 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 754093007699 intersubunit interface [polypeptide binding]; other site 754093007700 active site 754093007701 Zn2+ binding site [ion binding]; other site 754093007702 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 754093007703 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007704 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 754093007705 Domain of unknown function (DUF389); Region: DUF389; cl00781 754093007706 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 754093007707 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 754093007708 molybdopterin cofactor binding site; other site 754093007709 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 754093007710 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 754093007711 molybdopterin cofactor binding site; other site 754093007712 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 754093007713 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 754093007714 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 754093007715 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 754093007716 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 754093007717 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 754093007718 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007719 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093007720 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093007721 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093007722 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093007723 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093007724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754093007725 Coenzyme A binding pocket [chemical binding]; other site 754093007726 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 754093007727 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 754093007728 putative active site [active] 754093007729 dimerization interface [polypeptide binding]; other site 754093007730 putative tRNAtyr binding site [nucleotide binding]; other site 754093007731 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 754093007732 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 754093007733 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 754093007734 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093007735 motif II; other site 754093007736 Integrase core domain; Region: rve_3; cl15866 754093007737 Integrase core domain; Region: rve; pfam00665 754093007738 Integrase core domain; Region: rve_3; cl15866 754093007739 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093007740 Transposase; Region: HTH_Tnp_1; pfam01527 754093007741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093007742 Transposase; Region: HTH_Tnp_1; cl17663 754093007743 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 754093007744 active site 754093007745 catalytic residues [active] 754093007746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 754093007747 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093007748 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093007749 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093007750 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007751 UTRA domain; Region: UTRA; cl17743 754093007752 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 754093007753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754093007754 DNA-binding site [nucleotide binding]; DNA binding site 754093007755 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 754093007756 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 754093007757 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 754093007758 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 754093007759 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 754093007760 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 754093007761 G1 box; other site 754093007762 putative GEF interaction site [polypeptide binding]; other site 754093007763 GTP/Mg2+ binding site [chemical binding]; other site 754093007764 Switch I region; other site 754093007765 G2 box; other site 754093007766 G3 box; other site 754093007767 Switch II region; other site 754093007768 G4 box; other site 754093007769 G5 box; other site 754093007770 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 754093007771 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 754093007772 glutamine synthetase; Provisional; Region: glnA; PRK09469 754093007773 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 754093007774 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 754093007775 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 754093007776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754093007777 putative active site [active] 754093007778 heme pocket [chemical binding]; other site 754093007779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754093007780 dimer interface [polypeptide binding]; other site 754093007781 phosphorylation site [posttranslational modification] 754093007782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093007783 ATP binding site [chemical binding]; other site 754093007784 Mg2+ binding site [ion binding]; other site 754093007785 G-X-G motif; other site 754093007786 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 754093007787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093007788 active site 754093007789 phosphorylation site [posttranslational modification] 754093007790 intermolecular recognition site; other site 754093007791 dimerization interface [polypeptide binding]; other site 754093007792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754093007793 Walker A motif; other site 754093007794 ATP binding site [chemical binding]; other site 754093007795 Walker B motif; other site 754093007796 arginine finger; other site 754093007797 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 754093007798 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 754093007799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754093007800 FeS/SAM binding site; other site 754093007801 HemN C-terminal domain; Region: HemN_C; pfam06969 754093007802 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 754093007803 G1 box; other site 754093007804 GTP/Mg2+ binding site [chemical binding]; other site 754093007805 Switch I region; other site 754093007806 G2 box; other site 754093007807 G3 box; other site 754093007808 Switch II region; other site 754093007809 G4 box; other site 754093007810 G5 box; other site 754093007811 DNA polymerase I; Provisional; Region: PRK05755 754093007812 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 754093007813 active site 754093007814 metal binding site 3; metal-binding site 754093007815 metal binding site 1 [ion binding]; metal-binding site 754093007816 metal binding site 2 [ion binding]; metal-binding site 754093007817 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 754093007818 putative DNA binding site [nucleotide binding]; other site 754093007819 putative metal binding site [ion binding]; other site 754093007820 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 754093007821 active site 754093007822 catalytic site [active] 754093007823 substrate binding site [chemical binding]; other site 754093007824 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 754093007825 active site 754093007826 DNA binding site [nucleotide binding] 754093007827 catalytic site [active] 754093007828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 754093007829 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007830 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093007831 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093007832 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093007833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 754093007834 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007835 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 754093007836 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 754093007837 catalytic residues [active] 754093007838 hinge region; other site 754093007839 alpha helical domain; other site 754093007840 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 754093007841 serine/threonine protein kinase; Provisional; Region: PRK11768 754093007842 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 754093007843 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 754093007844 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 754093007845 GTP binding site; other site 754093007846 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 754093007847 potassium transporter; Provisional; Region: PRK10750 754093007848 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 754093007849 hypothetical protein; Provisional; Region: PRK11568 754093007850 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 754093007851 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 754093007852 proline dipeptidase; Provisional; Region: PRK13607 754093007853 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 754093007854 active site 754093007855 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 754093007856 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 754093007857 substrate binding site [chemical binding]; other site 754093007858 oxyanion hole (OAH) forming residues; other site 754093007859 trimer interface [polypeptide binding]; other site 754093007860 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 754093007861 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 754093007862 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 754093007863 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 754093007864 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 754093007865 dimer interface [polypeptide binding]; other site 754093007866 active site 754093007867 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 754093007868 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 754093007869 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 754093007870 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 754093007871 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 754093007872 active site 754093007873 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 754093007874 sec-independent translocase; Provisional; Region: PRK01770 754093007875 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 754093007876 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 754093007877 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 754093007878 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 754093007879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 754093007880 SCP-2 sterol transfer family; Region: SCP2; pfam02036 754093007881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 754093007882 S-adenosylmethionine binding site [chemical binding]; other site 754093007883 DNA recombination protein RmuC; Provisional; Region: PRK10361 754093007884 RmuC family; Region: RmuC; pfam02646 754093007885 uridine phosphorylase; Provisional; Region: PRK11178 754093007886 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 754093007887 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 754093007888 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 754093007889 THF binding site; other site 754093007890 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 754093007891 substrate binding site [chemical binding]; other site 754093007892 THF binding site; other site 754093007893 zinc-binding site [ion binding]; other site 754093007894 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 754093007895 putative hydrolase; Provisional; Region: PRK10976 754093007896 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093007897 active site 754093007898 motif I; other site 754093007899 motif II; other site 754093007900 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093007901 lysophospholipase L2; Provisional; Region: PRK10749 754093007902 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 754093007903 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 754093007904 LysE type translocator; Region: LysE; cl00565 754093007905 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 754093007906 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754093007907 ATP binding site [chemical binding]; other site 754093007908 putative Mg++ binding site [ion binding]; other site 754093007909 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754093007910 nucleotide binding region [chemical binding]; other site 754093007911 ATP-binding site [chemical binding]; other site 754093007912 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 754093007913 Helicase and RNase D C-terminal; Region: HRDC; smart00341 754093007914 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 754093007915 dimerization interface [polypeptide binding]; other site 754093007916 substrate binding site [chemical binding]; other site 754093007917 active site 754093007918 calcium binding site [ion binding]; other site 754093007919 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 754093007920 CoenzymeA binding site [chemical binding]; other site 754093007921 subunit interaction site [polypeptide binding]; other site 754093007922 PHB binding site; other site 754093007923 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 754093007924 EamA-like transporter family; Region: EamA; cl17759 754093007925 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093007926 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093007927 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007928 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 754093007929 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 754093007930 Cl binding site [ion binding]; other site 754093007931 oligomer interface [polypeptide binding]; other site 754093007932 Predicted periplasmic protein [Function unknown]; Region: COG3698 754093007933 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 754093007934 Uncharacterized conserved protein [Function unknown]; Region: COG1912 754093007935 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 754093007936 Part of AAA domain; Region: AAA_19; pfam13245 754093007937 Family description; Region: UvrD_C_2; pfam13538 754093007938 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 754093007939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093007940 motif II; other site 754093007941 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 754093007942 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 754093007943 active site 754093007944 DNA binding site [nucleotide binding] 754093007945 Int/Topo IB signature motif; other site 754093007946 hypothetical protein; Provisional; Region: PRK10963 754093007947 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 754093007948 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 754093007949 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 754093007950 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 754093007951 hypothetical protein; Provisional; Region: PRK09807 754093007952 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 754093007953 putative iron binding site [ion binding]; other site 754093007954 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 754093007955 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 754093007956 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 754093007957 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 754093007958 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 754093007959 domain interfaces; other site 754093007960 active site 754093007961 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 754093007962 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 754093007963 active site 754093007964 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 754093007965 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 754093007966 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 754093007967 HemY protein N-terminus; Region: HemY_N; pfam07219 754093007968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 754093007969 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 754093007970 Sulfatase; Region: Sulfatase; pfam00884 754093007971 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 754093007972 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 754093007973 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093007974 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 754093007975 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 754093007976 FeS/SAM binding site; other site 754093007977 putative transport protein YifK; Provisional; Region: PRK10746 754093007978 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 754093007979 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 754093007980 putative common antigen polymerase; Provisional; Region: PRK02975 754093007981 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 754093007982 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 754093007983 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 754093007984 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 754093007985 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 754093007986 inhibitor-cofactor binding pocket; inhibition site 754093007987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093007988 catalytic residue [active] 754093007989 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 754093007990 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 754093007991 substrate binding site; other site 754093007992 tetramer interface; other site 754093007993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754093007994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754093007995 NAD(P) binding site [chemical binding]; other site 754093007996 active site 754093007997 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 754093007998 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 754093007999 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 754093008000 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 754093008001 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 754093008002 active site 754093008003 homodimer interface [polypeptide binding]; other site 754093008004 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 754093008005 Chain length determinant protein; Region: Wzz; pfam02706 754093008006 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 754093008007 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 754093008008 Mg++ binding site [ion binding]; other site 754093008009 putative catalytic motif [active] 754093008010 substrate binding site [chemical binding]; other site 754093008011 transcription termination factor Rho; Provisional; Region: rho; PRK09376 754093008012 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 754093008013 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 754093008014 RNA binding site [nucleotide binding]; other site 754093008015 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 754093008016 multimer interface [polypeptide binding]; other site 754093008017 Walker A motif; other site 754093008018 ATP binding site [chemical binding]; other site 754093008019 Walker B motif; other site 754093008020 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 754093008021 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 754093008022 catalytic residues [active] 754093008023 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 754093008024 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 754093008025 ATP binding site [chemical binding]; other site 754093008026 Mg++ binding site [ion binding]; other site 754093008027 motif III; other site 754093008028 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754093008029 nucleotide binding region [chemical binding]; other site 754093008030 ATP-binding site [chemical binding]; other site 754093008031 exopolyphosphatase; Region: exo_poly_only; TIGR03706 754093008032 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 754093008033 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 754093008034 Part of AAA domain; Region: AAA_19; pfam13245 754093008035 Family description; Region: UvrD_C_2; pfam13538 754093008036 Transposase; Region: HTH_Tnp_1; cl17663 754093008037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093008038 Transposase; Region: HTH_Tnp_1; cl17663 754093008039 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093008040 HTH-like domain; Region: HTH_21; pfam13276 754093008041 Integrase core domain; Region: rve; pfam00665 754093008042 PemK-like protein; Region: PemK; cl00995 754093008043 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 754093008044 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 754093008045 threonine dehydratase; Reviewed; Region: PRK09224 754093008046 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 754093008047 tetramer interface [polypeptide binding]; other site 754093008048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093008049 catalytic residue [active] 754093008050 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 754093008051 putative Ile/Val binding site [chemical binding]; other site 754093008052 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 754093008053 putative Ile/Val binding site [chemical binding]; other site 754093008054 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 754093008055 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 754093008056 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 754093008057 homodimer interface [polypeptide binding]; other site 754093008058 substrate-cofactor binding pocket; other site 754093008059 catalytic residue [active] 754093008060 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 754093008061 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 754093008062 PYR/PP interface [polypeptide binding]; other site 754093008063 dimer interface [polypeptide binding]; other site 754093008064 TPP binding site [chemical binding]; other site 754093008065 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 754093008066 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 754093008067 TPP-binding site [chemical binding]; other site 754093008068 dimer interface [polypeptide binding]; other site 754093008069 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 754093008070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754093008071 Walker A motif; other site 754093008072 ATP binding site [chemical binding]; other site 754093008073 Walker B motif; other site 754093008074 Transposase; Region: DEDD_Tnp_IS110; pfam01548 754093008075 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 754093008076 hypothetical protein; Provisional; Region: PRK11027 754093008077 transcriptional regulator HdfR; Provisional; Region: PRK03601 754093008078 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093008079 LysR substrate binding domain; Region: LysR_substrate; pfam03466 754093008080 dimerization interface [polypeptide binding]; other site 754093008081 Transcriptional regulators [Transcription]; Region: FadR; COG2186 754093008082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754093008083 DNA-binding site [nucleotide binding]; DNA binding site 754093008084 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 754093008085 putative transporter; Provisional; Region: PRK10504 754093008086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093008087 putative substrate translocation pore; other site 754093008088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093008089 transcriptional repressor RbsR; Provisional; Region: PRK10423 754093008090 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754093008091 DNA binding site [nucleotide binding] 754093008092 domain linker motif; other site 754093008093 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 754093008094 dimerization interface [polypeptide binding]; other site 754093008095 ligand binding site [chemical binding]; other site 754093008096 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 754093008097 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754093008098 substrate binding site [chemical binding]; other site 754093008099 dimer interface [polypeptide binding]; other site 754093008100 ATP binding site [chemical binding]; other site 754093008101 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 754093008102 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 754093008103 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754093008104 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754093008105 TM-ABC transporter signature motif; other site 754093008106 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754093008107 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 754093008108 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754093008109 Walker A/P-loop; other site 754093008110 ATP binding site [chemical binding]; other site 754093008111 Q-loop/lid; other site 754093008112 ABC transporter signature motif; other site 754093008113 Walker B; other site 754093008114 D-loop; other site 754093008115 H-loop/switch region; other site 754093008116 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754093008117 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 754093008118 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 754093008119 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 754093008120 potassium uptake protein; Region: kup; TIGR00794 754093008121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754093008122 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 754093008123 Walker A motif; other site 754093008124 ATP binding site [chemical binding]; other site 754093008125 Walker B motif; other site 754093008126 arginine finger; other site 754093008127 regulatory ATPase RavA; Provisional; Region: PRK13531 754093008128 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 754093008129 hypothetical protein; Provisional; Region: yieM; PRK10997 754093008130 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 754093008131 metal ion-dependent adhesion site (MIDAS); other site 754093008132 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 754093008133 dimer interface [polypeptide binding]; other site 754093008134 active site 754093008135 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 754093008136 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754093008137 putative DNA binding site [nucleotide binding]; other site 754093008138 putative Zn2+ binding site [ion binding]; other site 754093008139 AsnC family; Region: AsnC_trans_reg; pfam01037 754093008140 FMN-binding protein MioC; Provisional; Region: PRK09004 754093008141 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 754093008142 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 754093008143 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 754093008144 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 754093008145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093008146 S-adenosylmethionine binding site [chemical binding]; other site 754093008147 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 754093008148 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 754093008149 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 754093008150 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 754093008151 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 754093008152 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 754093008153 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 754093008154 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 754093008155 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 754093008156 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 754093008157 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 754093008158 beta subunit interaction interface [polypeptide binding]; other site 754093008159 Walker A motif; other site 754093008160 ATP binding site [chemical binding]; other site 754093008161 Walker B motif; other site 754093008162 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 754093008163 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 754093008164 core domain interface [polypeptide binding]; other site 754093008165 delta subunit interface [polypeptide binding]; other site 754093008166 epsilon subunit interface [polypeptide binding]; other site 754093008167 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 754093008168 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 754093008169 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 754093008170 alpha subunit interaction interface [polypeptide binding]; other site 754093008171 Walker A motif; other site 754093008172 ATP binding site [chemical binding]; other site 754093008173 Walker B motif; other site 754093008174 inhibitor binding site; inhibition site 754093008175 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 754093008176 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 754093008177 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 754093008178 gamma subunit interface [polypeptide binding]; other site 754093008179 epsilon subunit interface [polypeptide binding]; other site 754093008180 LBP interface [polypeptide binding]; other site 754093008181 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 754093008182 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 754093008183 Substrate binding site; other site 754093008184 Mg++ binding site; other site 754093008185 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 754093008186 active site 754093008187 substrate binding site [chemical binding]; other site 754093008188 CoA binding site [chemical binding]; other site 754093008189 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 754093008190 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 754093008191 glutaminase active site [active] 754093008192 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 754093008193 dimer interface [polypeptide binding]; other site 754093008194 active site 754093008195 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 754093008196 dimer interface [polypeptide binding]; other site 754093008197 active site 754093008198 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 754093008199 Putative transposase; Region: Y2_Tnp; pfam04986 754093008200 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754093008201 substrate binding pocket [chemical binding]; other site 754093008202 membrane-bound complex binding site; other site 754093008203 hinge residues; other site 754093008204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093008205 dimer interface [polypeptide binding]; other site 754093008206 conserved gate region; other site 754093008207 putative PBP binding loops; other site 754093008208 ABC-ATPase subunit interface; other site 754093008209 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 754093008210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093008211 dimer interface [polypeptide binding]; other site 754093008212 conserved gate region; other site 754093008213 putative PBP binding loops; other site 754093008214 ABC-ATPase subunit interface; other site 754093008215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093008216 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 754093008217 Q-loop/lid; other site 754093008218 ABC transporter signature motif; other site 754093008219 Walker B; other site 754093008220 D-loop; other site 754093008221 H-loop/switch region; other site 754093008222 transcriptional regulator PhoU; Provisional; Region: PRK11115 754093008223 PhoU domain; Region: PhoU; pfam01895 754093008224 PhoU domain; Region: PhoU; pfam01895 754093008225 Salmonella outer protein D; Region: SopD; cl14701 754093008226 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093008227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093008228 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093008229 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093008230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093008231 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093008232 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093008233 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093008234 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093008235 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 754093008236 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 754093008237 trimer interface [polypeptide binding]; other site 754093008238 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 754093008239 trimer interface [polypeptide binding]; other site 754093008240 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 754093008241 trimer interface [polypeptide binding]; other site 754093008242 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 754093008243 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 754093008244 trimer interface [polypeptide binding]; other site 754093008245 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 754093008246 Haemagglutinin; Region: HIM; pfam05662 754093008247 Haemagglutinin; Region: HIM; pfam05662 754093008248 YadA-like C-terminal region; Region: YadA; pfam03895 754093008249 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 754093008250 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 754093008251 phosphate binding site [ion binding]; other site 754093008252 putative rRNA methylase; Provisional; Region: PRK10358 754093008253 serine acetyltransferase; Provisional; Region: cysE; PRK11132 754093008254 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 754093008255 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 754093008256 trimer interface [polypeptide binding]; other site 754093008257 active site 754093008258 substrate binding site [chemical binding]; other site 754093008259 CoA binding site [chemical binding]; other site 754093008260 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 754093008261 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 754093008262 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 754093008263 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 754093008264 SecA binding site; other site 754093008265 Preprotein binding site; other site 754093008266 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 754093008267 GSH binding site [chemical binding]; other site 754093008268 catalytic residues [active] 754093008269 AmiB activator; Provisional; Region: PRK11637 754093008270 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 754093008271 Peptidase family M23; Region: Peptidase_M23; pfam01551 754093008272 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 754093008273 NodB motif; other site 754093008274 putative active site [active] 754093008275 putative catalytic site [active] 754093008276 Zn binding site [ion binding]; other site 754093008277 putative glycosyl transferase; Provisional; Region: PRK10073 754093008278 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 754093008279 active site 754093008280 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 754093008281 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 754093008282 NAD(P) binding site [chemical binding]; other site 754093008283 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 754093008284 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 754093008285 substrate-cofactor binding pocket; other site 754093008286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093008287 catalytic residue [active] 754093008288 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 754093008289 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 754093008290 NADP binding site [chemical binding]; other site 754093008291 homopentamer interface [polypeptide binding]; other site 754093008292 substrate binding site [chemical binding]; other site 754093008293 active site 754093008294 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 754093008295 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 754093008296 putative active site [active] 754093008297 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 754093008298 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 754093008299 putative active site [active] 754093008300 O-Antigen ligase; Region: Wzy_C; pfam04932 754093008301 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 754093008302 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 754093008303 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 754093008304 Ligand binding site; other site 754093008305 metal-binding site 754093008306 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 754093008307 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 754093008308 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 754093008309 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 754093008310 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 754093008311 Ligand binding site; other site 754093008312 metal-binding site 754093008313 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 754093008314 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 754093008315 Ligand binding site; other site 754093008316 metal-binding site 754093008317 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 754093008318 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 754093008319 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 754093008320 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754093008321 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 754093008322 putative active site [active] 754093008323 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 754093008324 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 754093008325 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 754093008326 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 754093008327 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 754093008328 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 754093008329 active site 754093008330 (T/H)XGH motif; other site 754093008331 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 754093008332 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 754093008333 DNA binding site [nucleotide binding] 754093008334 catalytic residue [active] 754093008335 H2TH interface [polypeptide binding]; other site 754093008336 putative catalytic residues [active] 754093008337 turnover-facilitating residue; other site 754093008338 intercalation triad [nucleotide binding]; other site 754093008339 8OG recognition residue [nucleotide binding]; other site 754093008340 putative reading head residues; other site 754093008341 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 754093008342 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 754093008343 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 754093008344 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 754093008345 hypothetical protein; Reviewed; Region: PRK00024 754093008346 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 754093008347 MPN+ (JAMM) motif; other site 754093008348 Zinc-binding site [ion binding]; other site 754093008349 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 754093008350 Flavoprotein; Region: Flavoprotein; pfam02441 754093008351 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 754093008352 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 754093008353 trimer interface [polypeptide binding]; other site 754093008354 active site 754093008355 division inhibitor protein; Provisional; Region: slmA; PRK09480 754093008356 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754093008357 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 754093008358 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 754093008359 putative active site [active] 754093008360 putative NTP binding site [chemical binding]; other site 754093008361 putative nucleic acid binding site [nucleotide binding]; other site 754093008362 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754093008363 active site 754093008364 ribonuclease PH; Reviewed; Region: rph; PRK00173 754093008365 Ribonuclease PH; Region: RNase_PH_bact; cd11362 754093008366 hexamer interface [polypeptide binding]; other site 754093008367 active site 754093008368 hypothetical protein; Provisional; Region: PRK11820 754093008369 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 754093008370 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 754093008371 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 754093008372 BRO family, N-terminal domain; Region: Bro-N; pfam02498 754093008373 Predicted membrane protein [Function unknown]; Region: COG2860 754093008374 UPF0126 domain; Region: UPF0126; pfam03458 754093008375 UPF0126 domain; Region: UPF0126; pfam03458 754093008376 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 754093008377 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 754093008378 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 754093008379 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 754093008380 nucleotide binding pocket [chemical binding]; other site 754093008381 K-X-D-G motif; other site 754093008382 catalytic site [active] 754093008383 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 754093008384 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 754093008385 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 754093008386 Zn2+ binding site [ion binding]; other site 754093008387 Mg2+ binding site [ion binding]; other site 754093008388 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 754093008389 synthetase active site [active] 754093008390 NTP binding site [chemical binding]; other site 754093008391 metal binding site [ion binding]; metal-binding site 754093008392 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 754093008393 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 754093008394 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 754093008395 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 754093008396 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 754093008397 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 754093008398 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 754093008399 generic binding surface II; other site 754093008400 DEAD-like helicases superfamily; Region: DEXDc; smart00487 754093008401 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754093008402 ATP binding site [chemical binding]; other site 754093008403 putative Mg++ binding site [ion binding]; other site 754093008404 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754093008405 nucleotide binding region [chemical binding]; other site 754093008406 ATP-binding site [chemical binding]; other site 754093008407 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 754093008408 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 754093008409 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 754093008410 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 754093008411 HTH-like domain; Region: HTH_21; pfam13276 754093008412 Integrase core domain; Region: rve; pfam00665 754093008413 Integrase core domain; Region: rve_2; pfam13333 754093008414 alpha-galactosidase; Provisional; Region: PRK15076 754093008415 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 754093008416 NAD binding site [chemical binding]; other site 754093008417 sugar binding site [chemical binding]; other site 754093008418 divalent metal binding site [ion binding]; other site 754093008419 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 754093008420 dimer interface [polypeptide binding]; other site 754093008421 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 754093008422 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093008423 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093008424 arginine decarboxylase; Provisional; Region: PRK15029 754093008425 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 754093008426 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 754093008427 homodimer interface [polypeptide binding]; other site 754093008428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093008429 catalytic residue [active] 754093008430 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 754093008431 arginine:agmatin antiporter; Provisional; Region: PRK10644 754093008432 putative metal dependent hydrolase; Provisional; Region: PRK11598 754093008433 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 754093008434 Sulfatase; Region: Sulfatase; pfam00884 754093008435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 754093008436 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 754093008437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093008438 active site 754093008439 phosphorylation site [posttranslational modification] 754093008440 intermolecular recognition site; other site 754093008441 dimerization interface [polypeptide binding]; other site 754093008442 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754093008443 DNA binding site [nucleotide binding] 754093008444 YjcZ-like protein; Region: YjcZ; pfam13990 754093008445 hypothetical protein; Provisional; Region: PRK09866 754093008446 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 754093008447 G2 box; other site 754093008448 Switch I region; other site 754093008449 G3 box; other site 754093008450 Switch II region; other site 754093008451 G4 box; other site 754093008452 G5 box; other site 754093008453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093008454 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093008455 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093008456 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093008457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093008458 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093008459 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093008460 hypothetical protein; Provisional; Region: PRK10220 754093008461 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 754093008462 PhnA protein; Region: PhnA; pfam03831 754093008463 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 754093008464 dimer interface [polypeptide binding]; other site 754093008465 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 754093008466 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 754093008467 Walker A/P-loop; other site 754093008468 ATP binding site [chemical binding]; other site 754093008469 Q-loop/lid; other site 754093008470 ABC transporter signature motif; other site 754093008471 Walker B; other site 754093008472 D-loop; other site 754093008473 H-loop/switch region; other site 754093008474 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 754093008475 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754093008476 substrate binding pocket [chemical binding]; other site 754093008477 membrane-bound complex binding site; other site 754093008478 hinge residues; other site 754093008479 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 754093008480 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 754093008481 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 754093008482 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 754093008483 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 754093008484 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754093008485 Walker A/P-loop; other site 754093008486 ATP binding site [chemical binding]; other site 754093008487 Q-loop/lid; other site 754093008488 ABC transporter signature motif; other site 754093008489 Walker B; other site 754093008490 D-loop; other site 754093008491 H-loop/switch region; other site 754093008492 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754093008493 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 754093008494 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 754093008495 Walker A/P-loop; other site 754093008496 ATP binding site [chemical binding]; other site 754093008497 Q-loop/lid; other site 754093008498 ABC transporter signature motif; other site 754093008499 Walker B; other site 754093008500 D-loop; other site 754093008501 H-loop/switch region; other site 754093008502 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 754093008503 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 754093008504 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 754093008505 active site 754093008506 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 754093008507 active site 754093008508 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754093008509 Coenzyme A binding pocket [chemical binding]; other site 754093008510 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 754093008511 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 754093008512 Coenzyme A binding pocket [chemical binding]; other site 754093008513 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754093008514 HAMP domain; Region: HAMP; pfam00672 754093008515 dimerization interface [polypeptide binding]; other site 754093008516 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754093008517 dimer interface [polypeptide binding]; other site 754093008518 phosphorylation site [posttranslational modification] 754093008519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093008520 ATP binding site [chemical binding]; other site 754093008521 Mg2+ binding site [ion binding]; other site 754093008522 G-X-G motif; other site 754093008523 Response regulator receiver domain; Region: Response_reg; pfam00072 754093008524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093008525 active site 754093008526 phosphorylation site [posttranslational modification] 754093008527 intermolecular recognition site; other site 754093008528 dimerization interface [polypeptide binding]; other site 754093008529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093008530 Walker A/P-loop; other site 754093008531 ATP binding site [chemical binding]; other site 754093008532 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754093008533 Q-loop/lid; other site 754093008534 ABC transporter signature motif; other site 754093008535 Walker B; other site 754093008536 D-loop; other site 754093008537 H-loop/switch region; other site 754093008538 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 754093008539 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754093008540 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 754093008541 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754093008542 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754093008543 TM-ABC transporter signature motif; other site 754093008544 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 754093008545 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 754093008546 putative ligand binding site [chemical binding]; other site 754093008547 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 754093008548 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 754093008549 intersubunit interface [polypeptide binding]; other site 754093008550 active site 754093008551 zinc binding site [ion binding]; other site 754093008552 Na+ binding site [ion binding]; other site 754093008553 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 754093008554 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754093008555 substrate binding site [chemical binding]; other site 754093008556 ATP binding site [chemical binding]; other site 754093008557 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754093008558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093008559 active site 754093008560 phosphorylation site [posttranslational modification] 754093008561 intermolecular recognition site; other site 754093008562 dimerization interface [polypeptide binding]; other site 754093008563 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754093008564 DNA binding site [nucleotide binding] 754093008565 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093008566 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 754093008567 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 754093008568 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 754093008569 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 754093008570 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 754093008571 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093008572 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093008573 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093008574 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 754093008575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093008576 putative substrate translocation pore; other site 754093008577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 754093008578 Predicted transcriptional regulator [Transcription]; Region: COG2944 754093008579 sequence-specific DNA binding site [nucleotide binding]; other site 754093008580 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 754093008581 salt bridge; other site 754093008582 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 754093008583 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 754093008584 cryptic adenine deaminase; Provisional; Region: PRK10027 754093008585 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 754093008586 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 754093008587 active site 754093008588 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 754093008589 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 754093008590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093008591 putative substrate translocation pore; other site 754093008592 regulatory protein UhpC; Provisional; Region: PRK11663 754093008593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093008594 putative substrate translocation pore; other site 754093008595 sensory histidine kinase UhpB; Provisional; Region: PRK11644 754093008596 MASE1; Region: MASE1; pfam05231 754093008597 Histidine kinase; Region: HisKA_3; pfam07730 754093008598 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 754093008599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093008600 active site 754093008601 phosphorylation site [posttranslational modification] 754093008602 intermolecular recognition site; other site 754093008603 dimerization interface [polypeptide binding]; other site 754093008604 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754093008605 DNA binding residues [nucleotide binding] 754093008606 dimerization interface [polypeptide binding]; other site 754093008607 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093008608 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 754093008609 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 754093008610 putative valine binding site [chemical binding]; other site 754093008611 dimer interface [polypeptide binding]; other site 754093008612 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 754093008613 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 754093008614 PYR/PP interface [polypeptide binding]; other site 754093008615 dimer interface [polypeptide binding]; other site 754093008616 TPP binding site [chemical binding]; other site 754093008617 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 754093008618 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 754093008619 TPP-binding site [chemical binding]; other site 754093008620 dimer interface [polypeptide binding]; other site 754093008621 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 754093008622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093008623 putative substrate translocation pore; other site 754093008624 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 754093008625 Domain of unknown function (DUF202); Region: DUF202; pfam02656 754093008626 Predicted membrane protein [Function unknown]; Region: COG2149 754093008627 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 754093008628 Sulfatase; Region: Sulfatase; pfam00884 754093008629 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093008630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093008631 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093008632 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093008633 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093008634 Helix-turn-helix domain; Region: HTH_18; pfam12833 754093008635 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 754093008636 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 754093008637 NAD binding site [chemical binding]; other site 754093008638 sugar binding site [chemical binding]; other site 754093008639 divalent metal binding site [ion binding]; other site 754093008640 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 754093008641 dimer interface [polypeptide binding]; other site 754093008642 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 754093008643 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 754093008644 PTS system arbutin-specific transporter subunit IIB; Provisional; Region: PRK09702 754093008645 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 754093008646 active site turn [active] 754093008647 phosphorylation site [posttranslational modification] 754093008648 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 754093008649 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 754093008650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754093008651 DNA-binding site [nucleotide binding]; DNA binding site 754093008652 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 754093008653 putative transporter; Validated; Region: PRK03818 754093008654 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 754093008655 TrkA-C domain; Region: TrkA_C; pfam02080 754093008656 TrkA-C domain; Region: TrkA_C; pfam02080 754093008657 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 754093008658 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 754093008659 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 754093008660 putative dimer interface [polypeptide binding]; other site 754093008661 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 754093008662 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 754093008663 putative dimer interface [polypeptide binding]; other site 754093008664 hypothetical protein; Provisional; Region: PRK11616 754093008665 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 754093008666 putative oxidoreductase; Provisional; Region: PRK11445 754093008667 hypothetical protein; Provisional; Region: PRK07236 754093008668 hypothetical protein; Provisional; Region: PRK10215 754093008669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093008670 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093008671 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093008672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093008673 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093008674 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093008675 hypothetical protein; Provisional; Region: PRK10215 754093008676 sugar phosphate phosphatase; Provisional; Region: PRK10513 754093008677 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093008678 active site 754093008679 motif I; other site 754093008680 motif II; other site 754093008681 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093008682 hypothetical protein; Provisional; Region: PRK11426 754093008683 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 754093008684 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 754093008685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093008686 Mg2+ binding site [ion binding]; other site 754093008687 G-X-G motif; other site 754093008688 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 754093008689 anchoring element; other site 754093008690 dimer interface [polypeptide binding]; other site 754093008691 ATP binding site [chemical binding]; other site 754093008692 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 754093008693 active site 754093008694 putative metal-binding site [ion binding]; other site 754093008695 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 754093008696 recF protein; Region: recf; TIGR00611 754093008697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093008698 Walker A/P-loop; other site 754093008699 ATP binding site [chemical binding]; other site 754093008700 Q-loop/lid; other site 754093008701 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093008702 ABC transporter signature motif; other site 754093008703 Walker B; other site 754093008704 D-loop; other site 754093008705 H-loop/switch region; other site 754093008706 DNA polymerase III subunit beta; Validated; Region: PRK05643 754093008707 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 754093008708 putative DNA binding surface [nucleotide binding]; other site 754093008709 dimer interface [polypeptide binding]; other site 754093008710 beta-clamp/clamp loader binding surface; other site 754093008711 beta-clamp/translesion DNA polymerase binding surface; other site 754093008712 DnaA N-terminal domain; Region: DnaA_N; pfam11638 754093008713 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 754093008714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754093008715 Walker A motif; other site 754093008716 ATP binding site [chemical binding]; other site 754093008717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 754093008718 Walker B motif; other site 754093008719 arginine finger; other site 754093008720 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 754093008721 DnaA box-binding interface [nucleotide binding]; other site 754093008722 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 754093008723 ribonuclease P; Reviewed; Region: rnpA; PRK01732 754093008724 hypothetical protein; Validated; Region: PRK00041 754093008725 membrane protein insertase; Provisional; Region: PRK01318 754093008726 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 754093008727 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 754093008728 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 754093008729 trmE is a tRNA modification GTPase; Region: trmE; cd04164 754093008730 G1 box; other site 754093008731 GTP/Mg2+ binding site [chemical binding]; other site 754093008732 Switch I region; other site 754093008733 G2 box; other site 754093008734 Switch II region; other site 754093008735 G3 box; other site 754093008736 G4 box; other site 754093008737 G5 box; other site 754093008738 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 754093008739 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093008740 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093008741 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 754093008742 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093008743 active site 754093008744 motif I; other site 754093008745 motif II; other site 754093008746 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 754093008747 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 754093008748 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 754093008749 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 754093008750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093008751 putative substrate translocation pore; other site 754093008752 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 754093008753 aromatic amino acid transport protein; Region: araaP; TIGR00837 754093008754 Integrase core domain; Region: rve_3; pfam13683 754093008755 Transposase; Region: HTH_Tnp_1; cl17663 754093008756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093008757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093008758 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093008759 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093008760 RHS Repeat; Region: RHS_repeat; pfam05593 754093008761 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 754093008762 RHS Repeat; Region: RHS_repeat; cl11982 754093008763 RHS Repeat; Region: RHS_repeat; cl11982 754093008764 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 754093008765 RHS Repeat; Region: RHS_repeat; pfam05593 754093008766 RHS protein; Region: RHS; pfam03527 754093008767 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 754093008768 putative glutathione S-transferase; Provisional; Region: PRK10357 754093008769 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 754093008770 putative C-terminal domain interface [polypeptide binding]; other site 754093008771 putative GSH binding site (G-site) [chemical binding]; other site 754093008772 putative dimer interface [polypeptide binding]; other site 754093008773 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 754093008774 dimer interface [polypeptide binding]; other site 754093008775 N-terminal domain interface [polypeptide binding]; other site 754093008776 putative substrate binding pocket (H-site) [chemical binding]; other site 754093008777 selenocysteine synthase; Provisional; Region: PRK04311 754093008778 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 754093008779 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 754093008780 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754093008781 catalytic residue [active] 754093008782 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 754093008783 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 754093008784 G1 box; other site 754093008785 putative GEF interaction site [polypeptide binding]; other site 754093008786 GTP/Mg2+ binding site [chemical binding]; other site 754093008787 Switch I region; other site 754093008788 G2 box; other site 754093008789 G3 box; other site 754093008790 Switch II region; other site 754093008791 G4 box; other site 754093008792 G5 box; other site 754093008793 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 754093008794 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 754093008795 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 754093008796 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093008797 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093008798 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093008799 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093008800 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093008801 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093008802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 754093008803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093008804 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 754093008805 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 754093008806 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 754093008807 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 754093008808 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 754093008809 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 754093008810 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093008811 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 754093008812 Putative transposase; Region: Y2_Tnp; pfam04986 754093008813 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 754093008814 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 754093008815 active site 754093008816 dimer interface [polypeptide binding]; other site 754093008817 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 754093008818 dimer interface [polypeptide binding]; other site 754093008819 active site 754093008820 aspartate kinase III; Validated; Region: PRK09084 754093008821 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 754093008822 nucleotide binding site [chemical binding]; other site 754093008823 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 754093008824 lysine allosteric regulatory site; other site 754093008825 dimer interface [polypeptide binding]; other site 754093008826 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 754093008827 dimer interface [polypeptide binding]; other site 754093008828 Integrase core domain; Region: rve; pfam00665 754093008829 Transposase; Region: HTH_Tnp_1; cl17663 754093008830 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093008831 Transposase; Region: HTH_Tnp_1; cl17663 754093008832 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093008833 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 754093008834 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 754093008835 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 754093008836 fumarate hydratase; Provisional; Region: PRK15389 754093008837 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 754093008838 Fumarase C-terminus; Region: Fumerase_C; pfam05683 754093008839 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 754093008840 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 754093008841 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093008842 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093008843 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093008844 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093008845 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093008846 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093008847 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 754093008848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093008849 active site 754093008850 phosphorylation site [posttranslational modification] 754093008851 intermolecular recognition site; other site 754093008852 dimerization interface [polypeptide binding]; other site 754093008853 Transcriptional regulator; Region: CitT; pfam12431 754093008854 sensory histidine kinase DcuS; Provisional; Region: PRK11086 754093008855 PAS domain; Region: PAS; smart00091 754093008856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093008857 ATP binding site [chemical binding]; other site 754093008858 Mg2+ binding site [ion binding]; other site 754093008859 G-X-G motif; other site 754093008860 Uncharacterized conserved protein [Function unknown]; Region: COG3592 754093008861 Predicted acetyltransferase [General function prediction only]; Region: COG2388 754093008862 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093008863 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093008864 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093008865 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093008866 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093008867 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093008868 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093008869 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 754093008870 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 754093008871 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754093008872 Walker A/P-loop; other site 754093008873 ATP binding site [chemical binding]; other site 754093008874 Q-loop/lid; other site 754093008875 ABC transporter signature motif; other site 754093008876 Walker B; other site 754093008877 D-loop; other site 754093008878 H-loop/switch region; other site 754093008879 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754093008880 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754093008881 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754093008882 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 754093008883 TM-ABC transporter signature motif; other site 754093008884 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754093008885 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754093008886 TM-ABC transporter signature motif; other site 754093008887 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 754093008888 AMP binding site [chemical binding]; other site 754093008889 metal binding site [ion binding]; metal-binding site 754093008890 active site 754093008891 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 754093008892 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 754093008893 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754093008894 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 754093008895 hypothetical protein; Provisional; Region: PRK05255 754093008896 peptidase PmbA; Provisional; Region: PRK11040 754093008897 cytochrome b562; Provisional; Region: PRK15058 754093008898 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 754093008899 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 754093008900 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754093008901 FeS/SAM binding site; other site 754093008902 ATP cone domain; Region: ATP-cone; pfam03477 754093008903 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 754093008904 Class III ribonucleotide reductase; Region: RNR_III; cd01675 754093008905 effector binding site; other site 754093008906 active site 754093008907 Zn binding site [ion binding]; other site 754093008908 glycine loop; other site 754093008909 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 754093008910 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 754093008911 active site turn [active] 754093008912 phosphorylation site [posttranslational modification] 754093008913 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 754093008914 trehalose repressor; Provisional; Region: treR; PRK09492 754093008915 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754093008916 DNA binding site [nucleotide binding] 754093008917 domain linker motif; other site 754093008918 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 754093008919 dimerization interface [polypeptide binding]; other site 754093008920 ligand binding site [chemical binding]; other site 754093008921 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 754093008922 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 754093008923 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 754093008924 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 754093008925 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093008926 motif II; other site 754093008927 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 754093008928 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 754093008929 homotrimer interaction site [polypeptide binding]; other site 754093008930 putative active site [active] 754093008931 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 754093008932 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 754093008933 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 754093008934 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 754093008935 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 754093008936 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 754093008937 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 754093008938 homotrimer interaction site [polypeptide binding]; other site 754093008939 putative active site [active] 754093008940 oxidoreductase; Provisional; Region: PRK12742 754093008941 classical (c) SDRs; Region: SDR_c; cd05233 754093008942 NAD(P) binding site [chemical binding]; other site 754093008943 active site 754093008944 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754093008945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754093008946 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 754093008947 Transposase; Region: HTH_Tnp_1; cl17663 754093008948 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093008949 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 754093008950 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 754093008951 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 754093008952 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 754093008953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 754093008954 RNase E inhibitor protein; Provisional; Region: PRK11191 754093008955 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 754093008956 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754093008957 Coenzyme A binding pocket [chemical binding]; other site 754093008958 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 754093008959 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093008960 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093008961 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093008962 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093008963 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093008964 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 754093008965 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 754093008966 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 754093008967 HIGH motif; other site 754093008968 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 754093008969 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 754093008970 active site 754093008971 KMSKS motif; other site 754093008972 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 754093008973 tRNA binding surface [nucleotide binding]; other site 754093008974 anticodon binding site; other site 754093008975 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 754093008976 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 754093008977 putative transposase OrfB; Reviewed; Region: PHA02517 754093008978 Integrase core domain; Region: rve; pfam00665 754093008979 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093008980 Transposase; Region: HTH_Tnp_1; pfam01527 754093008981 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 754093008982 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 754093008983 Walker A/P-loop; other site 754093008984 ATP binding site [chemical binding]; other site 754093008985 Q-loop/lid; other site 754093008986 ABC transporter signature motif; other site 754093008987 Walker B; other site 754093008988 D-loop; other site 754093008989 H-loop/switch region; other site 754093008990 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 754093008991 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754093008992 ABC-ATPase subunit interface; other site 754093008993 dimer interface [polypeptide binding]; other site 754093008994 putative PBP binding regions; other site 754093008995 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 754093008996 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754093008997 dimer interface [polypeptide binding]; other site 754093008998 ABC-ATPase subunit interface; other site 754093008999 putative PBP binding regions; other site 754093009000 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 754093009001 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 754093009002 siderophore binding site; other site 754093009003 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 754093009004 Secretin and TonB N terminus short domain; Region: STN; smart00965 754093009005 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 754093009006 FecR protein; Region: FecR; pfam04773 754093009007 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 754093009008 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754093009009 DNA binding residues [nucleotide binding] 754093009010 putative transposase OrfB; Reviewed; Region: PHA02517 754093009011 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 754093009012 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 754093009013 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 754093009014 Transposase; Region: HTH_Tnp_1; pfam01527 754093009015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093009016 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 754093009017 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 754093009018 Integrase core domain; Region: rve_3; cl15866 754093009019 Integrase core domain; Region: rve_3; pfam13683 754093009020 Transposase; Region: HTH_Tnp_1; cl17663 754093009021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093009022 Transposase; Region: HTH_Tnp_1; cl17663 754093009023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093009024 hypothetical protein; Provisional; Region: PRK10515 754093009025 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 754093009026 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754093009027 RNA binding surface [nucleotide binding]; other site 754093009028 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 754093009029 probable active site [active] 754093009030 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 754093009031 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754093009032 putative DNA binding site [nucleotide binding]; other site 754093009033 putative Zn2+ binding site [ion binding]; other site 754093009034 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 754093009035 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 754093009036 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 754093009037 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 754093009038 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 754093009039 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 754093009040 putative NAD(P) binding site [chemical binding]; other site 754093009041 catalytic Zn binding site [ion binding]; other site 754093009042 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 754093009043 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 754093009044 active site pocket [active] 754093009045 oxyanion hole [active] 754093009046 catalytic triad [active] 754093009047 active site nucleophile [active] 754093009048 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 754093009049 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 754093009050 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 754093009051 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009052 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009053 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093009054 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093009055 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 754093009056 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 754093009057 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 754093009058 substrate binding pocket [chemical binding]; other site 754093009059 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 754093009060 B12 binding site [chemical binding]; other site 754093009061 cobalt ligand [ion binding]; other site 754093009062 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 754093009063 transcriptional repressor IclR; Provisional; Region: PRK11569 754093009064 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 754093009065 Bacterial transcriptional regulator; Region: IclR; pfam01614 754093009066 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009067 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 754093009068 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 754093009069 isocitrate lyase; Provisional; Region: PRK15063 754093009070 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 754093009071 tetramer interface [polypeptide binding]; other site 754093009072 active site 754093009073 Mg2+/Mn2+ binding site [ion binding]; other site 754093009074 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 754093009075 malate synthase; Validated; Region: PRK09255 754093009076 active site 754093009077 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 754093009078 homoserine O-succinyltransferase; Provisional; Region: PRK05368 754093009079 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 754093009080 proposed active site lysine [active] 754093009081 conserved cys residue [active] 754093009082 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009083 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 754093009084 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754093009085 Coenzyme A binding pocket [chemical binding]; other site 754093009086 hypothetical protein; Provisional; Region: PRK10039 754093009087 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 754093009088 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 754093009089 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 754093009090 Acyltransferase family; Region: Acyl_transf_3; pfam01757 754093009091 Transposase; Region: HTH_Tnp_1; cl17663 754093009092 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 754093009093 HTH-like domain; Region: HTH_21; pfam13276 754093009094 Integrase core domain; Region: rve; pfam00665 754093009095 Integrase core domain; Region: rve_2; pfam13333 754093009096 YsaB-like lipoprotein; Region: YsaB; pfam13983 754093009097 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 754093009098 dimer interface [polypeptide binding]; other site 754093009099 motif 1; other site 754093009100 active site 754093009101 motif 2; other site 754093009102 motif 3; other site 754093009103 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 754093009104 DALR anticodon binding domain; Region: DALR_1; pfam05746 754093009105 anticodon binding site; other site 754093009106 tRNA binding surface [nucleotide binding]; other site 754093009107 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 754093009108 DNA-binding site [nucleotide binding]; DNA binding site 754093009109 RNA-binding motif; other site 754093009110 Predicted transcriptional regulator [Transcription]; Region: COG2944 754093009111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754093009112 non-specific DNA binding site [nucleotide binding]; other site 754093009113 salt bridge; other site 754093009114 sequence-specific DNA binding site [nucleotide binding]; other site 754093009115 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 754093009116 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 754093009117 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 754093009118 dimerization interface [polypeptide binding]; other site 754093009119 ligand binding site [chemical binding]; other site 754093009120 NADP binding site [chemical binding]; other site 754093009121 catalytic site [active] 754093009122 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 754093009123 ligand binding site [chemical binding]; other site 754093009124 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 754093009125 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 754093009126 molybdopterin cofactor binding site [chemical binding]; other site 754093009127 substrate binding site [chemical binding]; other site 754093009128 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 754093009129 molybdopterin cofactor binding site; other site 754093009130 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 754093009131 Autotransporter beta-domain; Region: Autotransporter; cl17461 754093009132 Autotransporter beta-domain; Region: Autotransporter; cl17461 754093009133 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 754093009134 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 754093009135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093009136 putative substrate translocation pore; other site 754093009137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009138 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093009139 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093009140 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009141 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 754093009142 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 754093009143 esterase; Provisional; Region: PRK10566 754093009144 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 754093009145 transcriptional repressor UlaR; Provisional; Region: PRK13509 754093009146 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 754093009147 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754093009148 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 754093009149 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 754093009150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 754093009151 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 754093009152 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 754093009153 active site 754093009154 P-loop; other site 754093009155 phosphorylation site [posttranslational modification] 754093009156 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 754093009157 active site 754093009158 phosphorylation site [posttranslational modification] 754093009159 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 754093009160 active site 754093009161 dimer interface [polypeptide binding]; other site 754093009162 magnesium binding site [ion binding]; other site 754093009163 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 754093009164 AP (apurinic/apyrimidinic) site pocket; other site 754093009165 DNA interaction; other site 754093009166 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 754093009167 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 754093009168 intersubunit interface [polypeptide binding]; other site 754093009169 active site 754093009170 Zn2+ binding site [ion binding]; other site 754093009171 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 754093009172 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 754093009173 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 754093009174 dimer interface [polypeptide binding]; other site 754093009175 ssDNA binding site [nucleotide binding]; other site 754093009176 tetramer (dimer of dimers) interface [polypeptide binding]; other site 754093009177 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 754093009178 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 754093009179 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 754093009180 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 754093009181 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009182 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009183 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093009184 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093009185 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009186 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 754093009187 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 754093009188 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 754093009189 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 754093009190 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 754093009191 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 754093009192 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 754093009193 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 754093009194 Hemerythrin-like domain; Region: Hr-like; cd12108 754093009195 Fe binding site [ion binding]; other site 754093009196 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754093009197 EamA-like transporter family; Region: EamA; pfam00892 754093009198 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 754093009199 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 754093009200 NADP binding site [chemical binding]; other site 754093009201 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 754093009202 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 754093009203 active site 754093009204 metal binding site [ion binding]; metal-binding site 754093009205 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 754093009206 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009207 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 754093009208 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 754093009209 active site 754093009210 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009211 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009212 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 754093009213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754093009214 FeS/SAM binding site; other site 754093009215 elongation factor P; Validated; Region: PRK00529 754093009216 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 754093009217 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 754093009218 RNA binding site [nucleotide binding]; other site 754093009219 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 754093009220 RNA binding site [nucleotide binding]; other site 754093009221 entericidin A; Provisional; Region: PRK09810 754093009222 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 754093009223 multidrug efflux system protein; Provisional; Region: PRK11431 754093009224 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 754093009225 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 754093009226 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 754093009227 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 754093009228 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 754093009229 Iron-sulfur protein interface; other site 754093009230 proximal quinone binding site [chemical binding]; other site 754093009231 C-subunit interface; other site 754093009232 distal quinone binding site; other site 754093009233 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 754093009234 D-subunit interface [polypeptide binding]; other site 754093009235 Iron-sulfur protein interface; other site 754093009236 proximal quinone binding site [chemical binding]; other site 754093009237 distal quinone binding site [chemical binding]; other site 754093009238 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 754093009239 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 754093009240 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 754093009241 L-aspartate oxidase; Provisional; Region: PRK06175 754093009242 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 754093009243 poxB regulator PoxA; Provisional; Region: PRK09350 754093009244 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 754093009245 motif 1; other site 754093009246 dimer interface [polypeptide binding]; other site 754093009247 active site 754093009248 motif 2; other site 754093009249 motif 3; other site 754093009250 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009251 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009253 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093009254 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093009255 Predicted integral membrane protein [Function unknown]; Region: COG5463 754093009256 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 754093009257 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 754093009258 active site 754093009259 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 754093009260 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 754093009261 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 754093009262 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 754093009263 exoribonuclease R; Provisional; Region: PRK11642 754093009264 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 754093009265 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 754093009266 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 754093009267 RNB domain; Region: RNB; pfam00773 754093009268 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 754093009269 RNA binding site [nucleotide binding]; other site 754093009270 Predicted transcriptional regulator [Transcription]; Region: COG1959 754093009271 transcriptional repressor NsrR; Provisional; Region: PRK11014 754093009272 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 754093009273 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 754093009274 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 754093009275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 754093009276 FtsH protease regulator HflC; Provisional; Region: PRK11029 754093009277 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 754093009278 FtsH protease regulator HflK; Provisional; Region: PRK10930 754093009279 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 754093009280 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 754093009281 GTPase HflX; Provisional; Region: PRK11058 754093009282 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 754093009283 HflX GTPase family; Region: HflX; cd01878 754093009284 G1 box; other site 754093009285 GTP/Mg2+ binding site [chemical binding]; other site 754093009286 Switch I region; other site 754093009287 G2 box; other site 754093009288 G3 box; other site 754093009289 Switch II region; other site 754093009290 G4 box; other site 754093009291 G5 box; other site 754093009292 bacterial Hfq-like; Region: Hfq; cd01716 754093009293 hexamer interface [polypeptide binding]; other site 754093009294 Sm1 motif; other site 754093009295 RNA binding site [nucleotide binding]; other site 754093009296 Sm2 motif; other site 754093009297 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 754093009298 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 754093009299 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 754093009300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093009301 ATP binding site [chemical binding]; other site 754093009302 Mg2+ binding site [ion binding]; other site 754093009303 G-X-G motif; other site 754093009304 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 754093009305 ATP binding site [chemical binding]; other site 754093009306 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 754093009307 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 754093009308 AMIN domain; Region: AMIN; pfam11741 754093009309 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 754093009310 active site 754093009311 metal binding site [ion binding]; metal-binding site 754093009312 ADP-binding protein; Provisional; Region: PRK10646 754093009313 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 754093009314 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 754093009315 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 754093009316 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009317 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009318 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 754093009319 epoxyqueuosine reductase; Region: TIGR00276 754093009320 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 754093009321 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 754093009322 catalytic site [active] 754093009323 putative active site [active] 754093009324 putative substrate binding site [chemical binding]; other site 754093009325 dimer interface [polypeptide binding]; other site 754093009326 GTPase RsgA; Reviewed; Region: PRK12288 754093009327 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 754093009328 RNA binding site [nucleotide binding]; other site 754093009329 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 754093009330 GTPase/Zn-binding domain interface [polypeptide binding]; other site 754093009331 GTP/Mg2+ binding site [chemical binding]; other site 754093009332 G4 box; other site 754093009333 G5 box; other site 754093009334 G1 box; other site 754093009335 Switch I region; other site 754093009336 G2 box; other site 754093009337 G3 box; other site 754093009338 Switch II region; other site 754093009339 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 754093009340 putative mechanosensitive channel protein; Provisional; Region: PRK10929 754093009341 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 754093009342 DNA-binding site [nucleotide binding]; DNA binding site 754093009343 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 754093009344 Mechanosensitive ion channel; Region: MS_channel; pfam00924 754093009345 inner membrane transporter YjeM; Provisional; Region: PRK15238 754093009346 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009347 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009348 putative transcriptional regulator; Provisional; Region: PRK11640 754093009349 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754093009350 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 754093009351 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 754093009352 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 754093009353 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 754093009354 DsbD alpha interface [polypeptide binding]; other site 754093009355 catalytic residues [active] 754093009356 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 754093009357 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 754093009358 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 754093009359 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 754093009360 Aspartase; Region: Aspartase; cd01357 754093009361 active sites [active] 754093009362 tetramer interface [polypeptide binding]; other site 754093009363 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 754093009364 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009366 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093009367 putative transporter; Provisional; Region: PRK11021 754093009368 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 754093009369 oligomerisation interface [polypeptide binding]; other site 754093009370 mobile loop; other site 754093009371 roof hairpin; other site 754093009372 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 754093009373 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 754093009374 ring oligomerisation interface [polypeptide binding]; other site 754093009375 ATP/Mg binding site [chemical binding]; other site 754093009376 stacking interactions; other site 754093009377 hinge regions; other site 754093009378 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 754093009379 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 754093009380 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 754093009381 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 754093009382 Domain of unknown function DUF21; Region: DUF21; pfam01595 754093009383 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 754093009384 Transporter associated domain; Region: CorC_HlyC; smart01091 754093009385 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 754093009386 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 754093009387 Surface antigen; Region: Bac_surface_Ag; pfam01103 754093009388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 754093009389 Family of unknown function (DUF490); Region: DUF490; pfam04357 754093009390 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 754093009391 putative active site pocket [active] 754093009392 dimerization interface [polypeptide binding]; other site 754093009393 putative catalytic residue [active] 754093009394 antitoxin ChpS; Provisional; Region: PRK11347 754093009395 toxin ChpB; Provisional; Region: PRK09812 754093009396 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 754093009397 dimer interface [polypeptide binding]; other site 754093009398 substrate binding site [chemical binding]; other site 754093009399 metal binding sites [ion binding]; metal-binding site 754093009400 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 754093009401 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 754093009402 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009403 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009404 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 754093009405 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 754093009406 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 754093009407 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 754093009408 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754093009409 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 754093009410 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 754093009411 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 754093009412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093009413 putative substrate translocation pore; other site 754093009414 POT family; Region: PTR2; pfam00854 754093009415 Integrase core domain; Region: rve_3; pfam13683 754093009416 putative transposase OrfB; Reviewed; Region: PHA02517 754093009417 HTH-like domain; Region: HTH_21; pfam13276 754093009418 Integrase core domain; Region: rve; pfam00665 754093009419 Integrase core domain; Region: rve_3; pfam13683 754093009420 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 754093009421 Transposase IS200 like; Region: Y1_Tnp; pfam01797 754093009422 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009423 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093009424 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093009425 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 754093009427 putative transposase OrfB; Reviewed; Region: PHA02517 754093009428 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009429 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093009430 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093009431 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009432 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754093009433 DNA binding residues [nucleotide binding] 754093009434 dimerization interface [polypeptide binding]; other site 754093009435 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754093009436 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 754093009437 membrane-bound complex binding site; other site 754093009438 hinge residues; other site 754093009439 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 754093009440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754093009441 dimer interface [polypeptide binding]; other site 754093009442 phosphorylation site [posttranslational modification] 754093009443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093009444 ATP binding site [chemical binding]; other site 754093009445 Mg2+ binding site [ion binding]; other site 754093009446 G-X-G motif; other site 754093009447 Response regulator receiver domain; Region: Response_reg; pfam00072 754093009448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093009449 active site 754093009450 phosphorylation site [posttranslational modification] 754093009451 intermolecular recognition site; other site 754093009452 dimerization interface [polypeptide binding]; other site 754093009453 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 754093009454 putative binding surface; other site 754093009455 active site 754093009456 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 754093009457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 754093009458 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 754093009459 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 754093009460 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 754093009461 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 754093009462 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 754093009463 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 754093009464 Homeodomain-like domain; Region: HTH_23; pfam13384 754093009465 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093009466 Transposase; Region: HTH_Tnp_1; pfam01527 754093009467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 754093009468 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 754093009469 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 754093009470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009471 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093009472 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093009473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 754093009474 HTH-like domain; Region: HTH_21; pfam13276 754093009475 Integrase core domain; Region: rve; pfam00665 754093009476 Integrase core domain; Region: rve_2; pfam13333 754093009477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 754093009478 TPR motif; other site 754093009479 binding surface 754093009480 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009481 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009482 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093009483 Methyltransferase domain; Region: Methyltransf_27; pfam13708 754093009484 Integrase core domain; Region: rve; pfam00665 754093009485 Integrase core domain; Region: rve_3; cl15866 754093009486 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093009487 Transposase; Region: HTH_Tnp_1; pfam01527 754093009488 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009489 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093009490 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009491 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754093009492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093009493 putative substrate translocation pore; other site 754093009494 sugar efflux transporter; Region: 2A0120; TIGR00899 754093009495 EamA-like transporter family; Region: EamA; pfam00892 754093009496 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 754093009497 EamA-like transporter family; Region: EamA; pfam00892 754093009498 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 754093009499 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009500 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009501 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093009502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009503 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093009504 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009505 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 754093009506 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 754093009507 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 754093009508 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 754093009509 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 754093009510 DNA binding residues [nucleotide binding] 754093009511 dimer interface [polypeptide binding]; other site 754093009512 [2Fe-2S] cluster binding site [ion binding]; other site 754093009513 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 754093009514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093009515 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 754093009516 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 754093009517 dimer interface [polypeptide binding]; other site 754093009518 ssDNA binding site [nucleotide binding]; other site 754093009519 tetramer (dimer of dimers) interface [polypeptide binding]; other site 754093009520 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 754093009521 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 754093009522 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 754093009523 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 754093009524 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 754093009525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 754093009526 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 754093009527 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 754093009528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009529 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093009530 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093009531 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009532 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093009533 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009534 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009535 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 754093009536 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754093009537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093009538 homodimer interface [polypeptide binding]; other site 754093009539 catalytic residue [active] 754093009540 alanine racemase; Reviewed; Region: alr; PRK00053 754093009541 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 754093009542 active site 754093009543 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754093009544 substrate binding site [chemical binding]; other site 754093009545 catalytic residues [active] 754093009546 dimer interface [polypeptide binding]; other site 754093009547 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 754093009548 Walker B motif; other site 754093009549 ATP binding site [chemical binding]; other site 754093009550 DNA binding loops [nucleotide binding] 754093009551 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 754093009552 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 754093009553 Walker A motif; other site 754093009554 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 754093009555 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 754093009556 NADP binding site [chemical binding]; other site 754093009557 dimer interface [polypeptide binding]; other site 754093009558 phage shock protein G; Reviewed; Region: pspG; PRK09459 754093009559 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009560 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009561 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093009562 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009563 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 754093009564 metal binding site 2 [ion binding]; metal-binding site 754093009565 putative DNA binding helix; other site 754093009566 metal binding site 1 [ion binding]; metal-binding site 754093009567 dimer interface [polypeptide binding]; other site 754093009568 structural Zn2+ binding site [ion binding]; other site 754093009569 hypothetical protein; Provisional; Region: PRK10428 754093009570 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 754093009571 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 754093009572 LexA repressor; Validated; Region: PRK00215 754093009573 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 754093009574 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 754093009575 Catalytic site [active] 754093009576 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 754093009577 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 754093009578 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 754093009579 putative acyl-acceptor binding pocket; other site 754093009580 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 754093009581 UbiA prenyltransferase family; Region: UbiA; pfam01040 754093009582 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 754093009583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009584 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093009585 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093009586 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009587 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 754093009588 HlyD family secretion protein; Region: HlyD_3; pfam13437 754093009589 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754093009590 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754093009591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754093009592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754093009593 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 754093009594 putative effector binding pocket; other site 754093009595 putative dimerization interface [polypeptide binding]; other site 754093009596 inner membrane protein YhjD; Region: TIGR00766 754093009597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093009598 metabolite-proton symporter; Region: 2A0106; TIGR00883 754093009599 putative substrate translocation pore; other site 754093009600 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 754093009601 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 754093009602 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 754093009603 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 754093009604 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 754093009605 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 754093009606 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 754093009607 Tetratricopeptide repeat; Region: TPR_16; pfam13432 754093009608 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 754093009609 TPR motif; other site 754093009610 binding surface 754093009611 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 754093009612 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 754093009613 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 754093009614 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 754093009615 cellulose synthase regulator protein; Provisional; Region: PRK11114 754093009616 cell division protein; Provisional; Region: PRK10037 754093009617 cell division protein; Provisional; Region: PRK10037 754093009618 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 754093009619 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 754093009620 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009622 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093009623 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009624 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009625 Protein of unknown function (DUF2819); Region: DUF2819; cl17862 754093009626 Protein of unknown function (DUF2819); Region: DUF2819; cl17862 754093009627 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 754093009628 Protein of unknown function (DUF3260); Region: DUF3260; cl11881 754093009629 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 754093009630 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 754093009631 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754093009632 Walker A/P-loop; other site 754093009633 ATP binding site [chemical binding]; other site 754093009634 Q-loop/lid; other site 754093009635 ABC transporter signature motif; other site 754093009636 Walker B; other site 754093009637 D-loop; other site 754093009638 H-loop/switch region; other site 754093009639 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 754093009640 dipeptide transporter; Provisional; Region: PRK10913 754093009641 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 754093009642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093009643 dimer interface [polypeptide binding]; other site 754093009644 conserved gate region; other site 754093009645 putative PBP binding loops; other site 754093009646 ABC-ATPase subunit interface; other site 754093009647 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 754093009648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754093009649 dimer interface [polypeptide binding]; other site 754093009650 conserved gate region; other site 754093009651 putative PBP binding loops; other site 754093009652 ABC-ATPase subunit interface; other site 754093009653 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754093009654 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 754093009655 peptide binding site [polypeptide binding]; other site 754093009656 PapC N-terminal domain; Region: PapC_N; pfam13954 754093009657 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 754093009658 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 754093009659 Integrase core domain; Region: rve_3; pfam13683 754093009660 Transposase; Region: HTH_Tnp_1; cl17663 754093009661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093009662 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 754093009663 HTH-like domain; Region: HTH_21; pfam13276 754093009664 Integrase core domain; Region: rve; pfam00665 754093009665 Integrase core domain; Region: rve_2; pfam13333 754093009666 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 754093009667 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 754093009668 active site 754093009669 homotrimer interface [polypeptide binding]; other site 754093009670 catalytic site [active] 754093009671 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 754093009672 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009674 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093009675 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093009676 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 754093009677 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 754093009678 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093009679 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009680 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093009681 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009682 putative transposase OrfB; Reviewed; Region: PHA02517 754093009683 HTH-like domain; Region: HTH_21; pfam13276 754093009684 Integrase core domain; Region: rve; pfam00665 754093009685 Integrase core domain; Region: rve_3; pfam13683 754093009686 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 754093009687 Autotransporter beta-domain; Region: Autotransporter; smart00869 754093009688 Domain of unknown function (DUF932); Region: DUF932; pfam06067 754093009689 Antirestriction protein; Region: Antirestrict; pfam03230 754093009690 Protein of unknown function (DUF987); Region: DUF987; pfam06174 754093009691 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 754093009692 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 754093009693 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 754093009694 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009695 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093009696 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093009697 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 754093009698 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 754093009699 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 754093009700 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 754093009701 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 754093009702 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 754093009703 Predicted membrane protein [Function unknown]; Region: COG2733 754093009704 Predicted membrane protein [Function unknown]; Region: COG2733 754093009705 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 754093009706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093009707 putative substrate translocation pore; other site 754093009708 Uncharacterized conserved protein [Function unknown]; Region: COG5464 754093009709 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 754093009710 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 754093009711 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754093009712 DNA-binding site [nucleotide binding]; DNA binding site 754093009713 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754093009714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754093009715 homodimer interface [polypeptide binding]; other site 754093009716 catalytic residue [active] 754093009717 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 754093009718 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009719 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009720 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093009721 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009722 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 754093009723 Uncharacterized small protein [Function unknown]; Region: COG2879 754093009724 carbon starvation protein A; Provisional; Region: PRK15015 754093009725 Carbon starvation protein CstA; Region: CstA; pfam02554 754093009726 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 754093009727 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 754093009728 dimer interface [polypeptide binding]; other site 754093009729 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 754093009730 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 754093009731 ligand binding site [chemical binding]; other site 754093009732 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754093009733 dimerization interface [polypeptide binding]; other site 754093009734 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 754093009735 dimer interface [polypeptide binding]; other site 754093009736 putative CheW interface [polypeptide binding]; other site 754093009737 D-galactonate transporter; Region: 2A0114; TIGR00893 754093009738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754093009739 Transposase; Region: HTH_Tnp_1; pfam01527 754093009740 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 754093009741 HTH-like domain; Region: HTH_21; pfam13276 754093009742 Integrase core domain; Region: rve; pfam00665 754093009743 Integrase core domain; Region: rve_2; pfam13333 754093009744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754093009745 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 754093009746 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 754093009747 phosphoglycerol transferase I; Provisional; Region: PRK03776 754093009748 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 754093009749 hypothetical protein; Provisional; Region: PRK11667 754093009750 DNA replication protein DnaC; Validated; Region: PRK07952 754093009751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754093009752 Walker A motif; other site 754093009753 ATP binding site [chemical binding]; other site 754093009754 Walker B motif; other site 754093009755 hypothetical protein; Provisional; Region: PRK09917 754093009756 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009757 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009758 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754093009759 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009760 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093009761 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754093009762 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754093009763 DNA binding residues [nucleotide binding] 754093009764 dimerization interface [polypeptide binding]; other site 754093009765 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 754093009766 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754093009767 DNA binding residues [nucleotide binding] 754093009768 dimerization interface [polypeptide binding]; other site 754093009769 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 754093009770 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 754093009771 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 754093009772 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 754093009773 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 754093009774 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 754093009775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754093009776 S-adenosylmethionine binding site [chemical binding]; other site 754093009777 DNA polymerase III subunit psi; Validated; Region: PRK06856 754093009778 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 754093009779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754093009780 Coenzyme A binding pocket [chemical binding]; other site 754093009781 dUMP phosphatase; Provisional; Region: PRK09449 754093009782 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093009783 motif II; other site 754093009784 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 754093009785 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 754093009786 G1 box; other site 754093009787 putative GEF interaction site [polypeptide binding]; other site 754093009788 GTP/Mg2+ binding site [chemical binding]; other site 754093009789 Switch I region; other site 754093009790 G2 box; other site 754093009791 G3 box; other site 754093009792 Switch II region; other site 754093009793 G4 box; other site 754093009794 G5 box; other site 754093009795 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 754093009796 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 754093009797 active site 754093009798 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 754093009799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754093009800 FeS/SAM binding site; other site 754093009801 hypothetical protein; Provisional; Region: PRK10977 754093009802 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 754093009803 intersubunit interface [polypeptide binding]; other site 754093009804 active site 754093009805 catalytic residue [active] 754093009806 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 754093009807 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 754093009808 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 754093009809 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 754093009810 phosphopentomutase; Provisional; Region: PRK05362 754093009811 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 754093009812 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 754093009813 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 754093009814 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009815 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 754093009816 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 754093009817 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 754093009818 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 754093009819 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754093009820 non-specific DNA binding site [nucleotide binding]; other site 754093009821 salt bridge; other site 754093009822 sequence-specific DNA binding site [nucleotide binding]; other site 754093009823 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 754093009824 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 754093009825 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 754093009826 hypothetical protein; Provisional; Region: PRK11246 754093009827 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 754093009828 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754093009829 motif II; other site 754093009830 DNA repair protein RadA; Region: sms; TIGR00416 754093009831 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 754093009832 Walker A motif/ATP binding site; other site 754093009833 ATP binding site [chemical binding]; other site 754093009834 Walker B motif; other site 754093009835 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 754093009836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754093009837 non-specific DNA binding site [nucleotide binding]; other site 754093009838 salt bridge; other site 754093009839 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 754093009840 sequence-specific DNA binding site [nucleotide binding]; other site 754093009841 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 754093009842 active site 754093009843 (T/H)XGH motif; other site 754093009844 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 754093009845 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 754093009846 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754093009847 Walker A/P-loop; other site 754093009848 ATP binding site [chemical binding]; other site 754093009849 Q-loop/lid; other site 754093009850 ABC transporter signature motif; other site 754093009851 Walker B; other site 754093009852 D-loop; other site 754093009853 H-loop/switch region; other site 754093009854 ABC transporter; Region: ABC_tran_2; pfam12848 754093009855 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754093009856 lytic murein transglycosylase; Provisional; Region: PRK11619 754093009857 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754093009858 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754093009859 catalytic residue [active] 754093009860 Trp operon repressor; Provisional; Region: PRK01381 754093009861 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 754093009862 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754093009863 catalytic core [active] 754093009864 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 754093009865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754093009866 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 754093009867 hypothetical protein; Provisional; Region: PRK10756 754093009868 CreA protein; Region: CreA; pfam05981 754093009869 DNA-binding response regulator CreB; Provisional; Region: PRK11083 754093009870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093009871 active site 754093009872 phosphorylation site [posttranslational modification] 754093009873 intermolecular recognition site; other site 754093009874 dimerization interface [polypeptide binding]; other site 754093009875 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754093009876 DNA binding site [nucleotide binding] 754093009877 sensory histidine kinase CreC; Provisional; Region: PRK11100 754093009878 sensory histidine kinase CreC; Provisional; Region: PRK11100 754093009879 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754093009880 dimerization interface [polypeptide binding]; other site 754093009881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754093009882 dimer interface [polypeptide binding]; other site 754093009883 phosphorylation site [posttranslational modification] 754093009884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754093009885 ATP binding site [chemical binding]; other site 754093009886 G-X-G motif; other site 754093009887 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754093009888 DNA binding site [nucleotide binding] 754093009889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754093009890 active site 754093009891 phosphorylation site [posttranslational modification] 754093009892 intermolecular recognition site; other site 754093009893 putative RNA methyltransferase; Provisional; Region: PRK10433 754093009894 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050